One-way valve for gastric implantation and preparation method thereof and balloon for assisting weight loss

Abstract

The present invention relates to the technical field of medical materials, and discloses a one-way valve for gastric implantation, a preparation method thereof, and a balloon for assisting weight loss. The one-way valve comprises an umbrella-shaped valve body and a check valve. The umbrella-shaped valve body also has a liquid inlet channel extending from its top end to a direction corresponding to the umbrella handle. The check valve comprises two sheets of fitted resin films. The opposite side edges of one resin film are connected to the opposite side edges of another resin film in a one-to-one correspondence. The end of the umbrella-shaped valve body corresponding to the liquid inlet channel is connected to one end of the check valve, so that the liquid inlet channel and the gap between the two resin films are connected. The preparation method of the one-way valve comprises: connecting the umbrella-shaped valve body and the check valve, specifically comprising the method of using a polyurethane solution to hang a film on the wall to make the umbrella-shaped valve body, and the method of using a coating method to make the resin film. The balloon comprises the one-way valve being arranged on a balloon body having an opening. The one-way valve and the balloon provided by the present application have good softness and are not prone to produce a foreign body sensation when implanted in the stomach.

Description

Technical Field

[0001] The invention relates to the technical field of medical materials, in particular to a one-way valve for stomach implantation and a preparation method thereof, and a balloon for assisting weight loss. Background Art

[0002] As of 2016, the number of obese patients in the world has reached 972 million, and the number of obese patients in various countries has been increasing year by year. It can be seen that there is a great need for obesity treatment technology and a great market demand for treatment-related products.

[0003] The existing balloon products on the market for implantation into the stomach to assist weight loss are mainly made of nylon, silicone, polyethylene, polyether polyurethane and other materials. The wall thickness of most products is about 1mm and the materials used are relatively hard, so the products are hard and produce greater friction on the inner wall of the stomach, which can easily cause adverse reactions such as gastric ulcers, gastric perforation, and obvious foreign body sensation after implantation.

[0004] In view of this, the present invention is proposed. Summary of the invention

[0005] The object of the present invention is to provide a one-way valve for gastric implantation, a preparation method of the one-way valve for gastric implantation and a balloon for assisting weight loss.

[0006] The present invention is achieved in that:

[0007] In a first aspect, the present invention provides a one-way valve for gastric implantation, comprising an umbrella-shaped valve body and a check valve, wherein a liquid inlet is provided at the top end of the umbrella-shaped valve body, and the umbrella-shaped valve body also has a liquid inlet channel extending from its top end in a direction corresponding to the umbrella handle, the liquid inlet channel is connected with the liquid inlet, and the check valve comprises two pieces of bonded resin films, the opposite side edges of one piece of the resin film are connected with the opposite side edges of the other piece of the resin film in a one-to-one correspondence, and the end of the umbrella-shaped valve body corresponding to the liquid inlet channel is connected with one end of the check valve, so that the liquid inlet channel is connected with the gap between the two pieces of the resin films.

[0008] In an optional embodiment, the material of the umbrella-shaped valve body is polyurethane, and the wall thickness of the umbrella-shaped valve body is 0.01-0.2 mm;

[0009] Preferably, the resin film is made of polyurethane, and the wall thickness of the resin film is 0.01-0.1 mm.

[0010] In an optional embodiment, the edges of the two resin films are connected by laser welding;

[0011] Preferably, the check valve and the umbrella-shaped valve body are connected by laser welding.

[0012] In a second aspect, the present invention provides a method for preparing a one-way valve for gastric implantation, which is used to prepare the one-way valve for gastric implantation as described in any one of the aforementioned embodiments, comprising:

[0013] Connecting one end of the check valve formed by two pieces of resin films whose edges are connected to the umbrella-shaped valve body;

[0014] Alternatively, the two resin films are connected to the umbrella-shaped valve body respectively, and then the edges of the two opposite sides of the two resin films are connected one by one.

[0015] In an optional embodiment, the method further comprises preparing the umbrella-shaped valve body:

[0016] Dipping a mold having at least one surface having the same shape as the umbrella-shaped valve body into a first polyurethane solution, taking out the mold after the surface is completely adhered to the first polyurethane solution and drying it, and removing the umbrella-shaped valve body obtained after drying from the mold surface, wherein the mass concentration of the first polyurethane solution is 5-25%;

[0017] Preferably, the drying time is at least 12 hours; more preferably, the drying is carried out in a fume hood;

[0018] Preferably, when the mold is immersed in the first polyurethane solution, it is taken as a criterion that no bubbles are generated during the immersion process.

[0019] In an optional embodiment, the hardness of the polyurethane in the first polyurethane solution is less than or equal to 60D;

[0020] Preferably, the hardness of the polyurethane in the first polyurethane solution is 50HA~60HD;

[0021] Preferably, the solvent of the first polyurethane solution includes at least one of tetrahydrofuran, dichloromethane, chloroform and hexafluoroisopropanol.

[0022] In an optional embodiment, the preparation of the umbrella-shaped valve body further includes preparing a first polyurethane solution, and the method of preparing the first polyurethane solution is:

[0023] After mixing the polyurethane with the solvent, dissolving them at a temperature of 10-60° C. and a stirring speed of 50-200 r / min;

[0024] Preferably, the device for preparing the first polyurethane solution is an optional evaporator.

[0025] In an optional embodiment, the method further includes preparing a resin film, wherein the resin film is prepared by attaching a second polyurethane solution to a surface of a plate-shaped mold, drying the plate-shaped mold, and peeling off the dried resin film from the plate-shaped mold, wherein the mass concentration of the second polyurethane solution is 5-25%;

[0026] Preferably, the hardness of the polyurethane in the second polyurethane solution is less than or equal to 60D;

[0027] Preferably, the hardness of the polyurethane in the second polyurethane solution is 50HA~60HD;

[0028] Preferably, the solvent of the second polyurethane solution includes at least one of tetrahydrofuran, dichloromethane, chloroform and hexafluoroisopropanol;

[0029] Preferably, the plate-shaped mold is a glass plate, and the resin film is prepared by pouring the second polyurethane solution onto the glass plate of the coater, coating the solution with a preset thickness of 0.25 to 2 mm using a coater, and drying the glass plate after coating, and removing the dried resin film from the glass plate; more preferably, the coating speed is 20 to 120 cm / min.

[0030] In a third aspect, the present invention provides a balloon for assisting weight loss, comprising a balloon body having an opening and a one-way valve as described in any one of the aforementioned embodiments or a one-way valve made by the preparation method as described in any one of the aforementioned embodiments, arranged at the opening, the umbrella-shaped valve body is buckled at the opening, the part of the umbrella-shaped valve body corresponding to the umbrella surface is connected to the outer wall of the balloon body, and the check valve is located inside the balloon body.

[0031] In an optional embodiment, the method for preparing the balloon is as follows: pouring a polyurethane solution having a mass concentration of 5 to 25% into a spherical mold;

[0032] After the inner wall of the mold is completely adhered to the polyurethane solution, the spherical mold is inverted to dry the spherical mold, and the balloon body obtained after drying is taken out from the spherical mold.

[0033] The present invention has the following beneficial effects:

[0034] The one-way valve for gastric implantation provided by the present application is connected to the opening of the balloon body, and the liquid can enter the balloon body from the liquid inlet channel through the gap between the two resin films. After the liquid continues to enter the balloon body, the balloon body expands. Under the hydraulic pressure inside the balloon body, the two resin films are tightly attached, so that the liquid in the balloon body cannot flow out from between the two resin films, achieving the effect that the liquid can only enter but not exit. The one-way valve provided by the present application is easy to connect to the balloon body due to the design of the specific shape of the umbrella-shaped valve body, so that the arc surface of the umbrella-shaped valve body and the arc surface of the balloon body fit closely. This connection method can make the balloon implanted in the human stomach almost without foreign body sensation. In addition, the shape of the umbrella-shaped valve body is easy to manufacture by using a mold to make the solution hang on the wall or apply it into a film, so as to obtain an umbrella-shaped valve body with small thickness and good softness.

[0035] In the preferred manufacturing method provided, by hanging or coating the solution on the wall and then drying the solution, a one-way valve with an extremely thin wall thickness can be obtained, and a one-way valve with a wall thickness of 0.01 to 0.2 mm can be obtained by using a polyurethane solution with a concentration of 5 to 25% in combination with the above-mentioned preparation method. The umbrella-shaped valve body of this thickness has good softness and is not prone to adverse reactions such as foreign body sensation, gastric ulcer and gastric perforation when implanted in the stomach. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for use in the embodiments are briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without creative work.

[0037] Figure 1 A front view of a one-way valve provided in an embodiment of the present application;

[0038] Figure 2 A left side view of a one-way valve provided in an embodiment of the present application;

[0039] Figure 3 for Figure 1 Sectional view at AA in the middle;

[0040] Figure 4 for Figure 2 Sectional view at the middle BB;

[0041] Figure 5 for Figure 4 The schematic diagram of the one-way valve from the perspective shown is obtained by cutting the umbrella-shaped valve body end of the one-way valve and tilting it at a certain angle toward the outside of the paper;

[0042] Figure 6 A cross-sectional view of a balloon for assisting weight loss provided in an embodiment of the present application.

[0043] Icon: 100- one-way valve; 110- umbrella-shaped valve body; 111- liquid inlet channel; 120- check valve; 121- resin film; 200- balloon body; 201- opening; 10- balloon. DETAILED DESCRIPTION

[0044] In order to make the purpose, technical scheme and advantages of the embodiments of the present invention clearer, the technical scheme in the embodiments of the present invention will be described clearly and completely below. If the specific conditions are not specified in the embodiments, they are carried out according to conventional conditions or conditions recommended by the manufacturer. If the manufacturer of the reagents or instruments used is not specified, they are all conventional products that can be purchased commercially.

[0045] The one-way valve 100 for gastric implantation and its preparation method and the balloon 10 for assisting weight loss provided by the present application are described in detail below.

[0046] like Figure 1-5 As shown, a one-way valve 100 for gastric implantation provided in an embodiment of the present application includes an umbrella-shaped valve body 110 and a check valve 120, wherein a liquid inlet is provided at the top end of the umbrella-shaped valve body 110, and the umbrella-shaped valve body 110 also has a liquid inlet channel 111 extending from its top end in a direction corresponding to the umbrella handle, and the liquid inlet channel 111 is connected with the liquid inlet, and the check valve 120 includes two pieces of bonded resin films 121, and the opposite side edges of one piece of the resin film 121 are connected with the opposite side edges of the other piece of the resin film 121 in a one-to-one correspondence, and the end of the umbrella-shaped valve body 110 corresponding to the liquid inlet channel 111 is connected with one end of the check valve 120, so that the liquid inlet channel 111 and the gap between the two pieces of the resin films 121 are connected.

[0047] like Figure 1-6 As shown, a balloon 10 for assisting weight loss provided in an embodiment of the present application includes a balloon body 200 having an opening 201 and a one-way valve 100 arranged at the opening 201, the umbrella-shaped valve body 110 is buckled at the opening 201, the part of the umbrella-shaped valve body 110 corresponding to the umbrella surface is connected to the outer wall of the balloon body 200, and the check valve 120 is located inside the balloon body 200.

[0048] The one-way valve 100 for gastric implantation provided in the present application is connected to the opening 201 of the balloon body 200, so that liquid can enter the balloon body 200 from the liquid inlet channel 111 through the gap between the two resin films 121. After the liquid continuously enters the balloon body 200, the balloon body 200 expands, and under the action of the hydraulic pressure inside the balloon body 200, the two resin films 121 are tightly attached, so that the liquid in the balloon body 200 cannot flow out from between the two resin films 121, thereby achieving the effect that liquid can only enter but not exit. The one-way valve 100 provided in the present application is easy to be connected to the balloon body 200 due to the specific shape design of the umbrella-shaped valve body 110, so that the curved surface of the umbrella-shaped valve body 110 and the curved surface of the balloon body 200 can fit closely. This connection method can reduce the foreign body sensation after the balloon 10 is implanted in the human stomach. In addition, the shape of the umbrella-shaped valve body 110 is easy to manufacture by using a mold to make the solution hang on the wall to form a film, so as to obtain an umbrella-shaped valve body 110 with small thickness and good softness.

[0049] The balloon 10 for assisting weight loss provided in the present application is implanted in the stomach. The liquid in the stomach enters the balloon body 200 and causes the balloon body 200 to expand continuously. The liquid in the expanded balloon 10 will not flow out of the balloon body 200 due to the action of the one-way valve 100. The expanded balloon 10 occupies a certain space in the stomach, so that people always have a sense of fullness, thereby achieving the effect of reducing food intake and thus losing weight.

[0050] Specifically, the liquid inlet channel 111 of the umbrella-shaped valve body 110 may be formed by being recessed in a direction from the umbrella top to the umbrella handle. Such a structure is more conducive to collecting liquid from the one-way valve 100 into the balloon 10 .

[0051] Preferably, in order to ensure the flexibility of the one-way valve 100, the umbrella-shaped valve body 110 is made of polyurethane, and the wall thickness of the umbrella-shaped valve body 110 is 0.01-0.2 mm. Further, the resin film 121 is also made of polyurethane, and the wall thickness of the resin film 121 is 0.01-0.1 mm.

[0052] Preferably, the edges of the two resin films 121 are connected by laser welding.

[0053] Preferably, the check valve 120 and the umbrella-shaped valve body 110 are connected by laser welding.

[0054] A method for preparing a one-way valve 100 for gastric implantation provided in an embodiment of the present application, which is used to prepare the one-way valve 100 for gastric implantation provided in an embodiment of the present application, comprises:

[0055] One end of the check valve 120 formed by two pieces of resin films 121 with connected edges is connected to the umbrella-shaped valve body 110; or two pieces of resin films 121 are connected to the umbrella-shaped valve body 110 respectively, and then the opposite side edges of the two pieces of resin films 121 are connected one by one.

[0056] The preparation method is specifically as follows:

[0057] S1. Preparation of polyurethane solution

[0058] The first polyurethane solution used to prepare the umbrella valve body 110 and the second polyurethane solution used to prepare the resin film 121 can be the same polyurethane solution. Therefore, when preparing the polyurethane solution, a polyurethane solution that meets the above requirements can be uniformly prepared to prepare the umbrella valve body 110 and the resin film 121.

[0059] The preparation method is: mix the polyurethane with the solvent, and to ensure that the polyurethane can be completely and quickly dissolved, place it on an optional evaporator, dissolve it at a temperature of 10~60℃ and a stirring speed of 50~200r / min to obtain a polyurethane solution with a mass concentration of 5~25%.

[0060] Preferably, in order to obtain a one-way valve 100 with better flexibility, the hardness of the selected polyurethane is less than or equal to 60D.

[0061] More preferably, in order to ensure that the one-way valve 100 has sufficient strength, meets the requirement of being not easily damaged and has good softness, the hardness of the selected polyurethane is 50HA~60HD.

[0062] Furthermore, the solvent of the polyurethane solution includes at least one of tetrahydrofuran, dichloromethane, chloroform and hexafluoroisopropanol. The above solvent can dissolve polyurethane well and obtain a polyurethane solution with suitable adhesion, so as to obtain an umbrella-shaped valve body 110 with suitable thickness.

[0063] S2. Preparation of umbrella-shaped valve body 110

[0064] A mold having at least one surface having the same shape as the umbrella-shaped valve body 110 (preferably a mold having the same shape as the umbrella-shaped valve body 110) is immersed in a first polyurethane solution. After the surface having the same shape as the umbrella-shaped valve body 110 is completely adhered to the polyurethane solution, the mold is taken out and placed in a ventilated and dry place to dry. The umbrella-shaped valve body 110 with extremely thin walls is removed from the mold surface and dried.

[0065] By making the solution hang on the wall and then drying the solution, the umbrella-shaped valve body 110 with extremely thin wall thickness can be obtained, and the umbrella-shaped valve body 110 with a wall thickness of 0.01-0.2 mm can be obtained by using a polyurethane solution with a concentration of 5-25% in combination with the above preparation method. The umbrella-shaped valve body 110 with this thickness has better softness and is not likely to cause adverse reactions such as foreign body sensation, gastric ulcer and gastric perforation when implanted in the stomach.

[0066] Preferably, the drying time is at least 12 hours; more preferably, the drying is performed in a fume hood.

[0067] Furthermore, when the mold is immersed in the first polyurethane solution, it is determined that no bubbles are generated during the immersion process. Bubbles generated during the immersion process may affect the uniformity of film formation.

[0068] When a mold having the same shape as the umbrella-shaped valve body 110 is immersed in the polyurethane solution, the top of the umbrella corresponding to the mold is at the top and the handle of the umbrella is at the bottom, and the mold is slowly immersed in the polyurethane solution with an angle of about 15 degrees up and down to avoid the generation of bubbles.

[0069] S3. Preparation of resin film 121

[0070] The polyurethane solution is attached to the surface of the plate-shaped mold, the plate-shaped mold is dried, and the dried resin film 121 is removed from the plate-shaped mold.

[0071] Preferably, the drying time is at least 12 hours; more preferably, the drying is performed in a fume hood.

[0072] Preferably, the plate-shaped mold is a glass plate, and the resin film 121 is prepared as follows: about 20 ml of the polyurethane solution is poured onto the glass plate of the coater (BEVS1811), and a coater with a preset thickness of 0.25 to 2 mm is used for coating and film formation. After coating, the glass plate is dried, and the dried resin film 121 is peeled off from the glass plate.

[0073] The 5-25% polyurethane solution is coated with a solution coating of 0.25-2mm, and the corresponding thickness after drying can be guaranteed to be less than 0.2mm. The low concentration solution corresponds to the thickness, and the high concentration solution corresponds to the thin coating method to ensure that the resin film 121 with a thickness range of 0.01-0.2mm is obtained. When used for gastric implantation, there is almost no foreign body sensation.

[0074] More preferably, to ensure uniformity of manufacturing rate and film thickness, the coating speed is 20-120 cm / min (eg, 20 cm / min, 40 cm / min, 60 cm / min, 80 cm / min, 100 cm / min or 120 cm / min).

[0075] S4. Assembly

[0076] The two resin films 121 of the same size and shape obtained in step S3 are bonded together, and the edges on both sides of the resin films 121 (edges in the length direction) are welded by a laser welding machine to obtain an ultra-thin check valve 120 .

[0077] One end of the ultra-thin check valve 120 is connected to the umbrella-shaped valve body 110 obtained in step S2 by using a laser welding machine.

[0078] Preferably, the material of the balloon body 200 assembled with the one-way valve 100 provided in the embodiment of the present application is also polyurethane, and its preparation method is: pouring a polyurethane solution with a mass concentration of 5~25% into a spherical mold; after the inner wall of the mold is completely adhered to the polyurethane solution, the spherical mold is inverted, the spherical mold is dried, and the balloon body 200 obtained after drying is taken out from the spherical mold.

[0079] Preferably, the polyurethane solution used to prepare the balloon body 200 is the same as the polyurethane solution used to prepare the umbrella valve body 110 .

[0080] Preferably, the polyurethane solution is poured into the spherical mold, and the spherical mold is rotated in the same direction (clockwise or counterclockwise) to allow the polyurethane solution to adhere to the inner wall of the spherical mold. By rotating the spherical mold in the same direction, the solution adheres to the wall, and a balloon 10 with better uniformity and smaller thickness can be obtained.

[0081] The present application also provides a method for preparing a balloon 10 for assisting weight loss, comprising:

[0082] S5. The one-way valve 100 assembled in step S4 is buckled at the opening 201 of the balloon body 200, so that the check valve 120 is located inside the balloon body 200, and the part of the umbrella-shaped valve body 110 corresponding to the umbrella surface is connected to the outer wall of the balloon body 200 by laser welding or other connecting methods.

[0083] The features and performance of the present invention are further described in detail below in conjunction with the embodiments.

[0084] Example 1

[0085] Preparation of the one-way valve 100:

[0086] An appropriate amount of polyurethane with a hardness of 60D was mixed with tetrahydrofuran, placed on an evaporator, and dissolved at a temperature of 25°C and a stirring speed of 100 r / min to obtain a polyurethane solution with a mass concentration of 5%.

[0087] The polyurethane solution is placed in a container, and an umbrella-shaped mold having the same shape as the target umbrella-shaped valve body 110 is slowly immersed in the polyurethane solution. After the surface of the umbrella-shaped mold is completely adhered to the polyurethane solution, it is taken out from the polyurethane solution and then placed in a fume hood for 24 hours. After drying, the molded umbrella-shaped valve body 110 is peeled off from the surface of the umbrella-shaped mold.

[0088] About 20 ml of the polyurethane solution is poured onto the glass plate of the coater, and the coater thickness is set to 0.7 mm and the speed is set to 70 cm / min. After coating, the glass plate is dried and the dried resin film 121 is peeled off from the glass plate.

[0089] The resin film 121 is cut into two pieces of the same size, and the two side edges of the two bonded resin films 121 in the length direction are connected one by one by laser welding to obtain the check valve 120, and the check valve 120 is welded to the umbrella-shaped valve body 110 by laser welding to obtain the one-way valve 100.

[0090] Preparation of balloon 200:

[0091] Pour the polyurethane solution into the spherical mold, rotate the spherical mold clockwise to allow the polyurethane solution to adhere to the inner wall of the spherical mold, and then invert the spherical mold with the opening 201 downward in the fume hood, with the opening 201 1 cm away from the table of the fume hood. Dry it for 24 hours, and then take out the balloon body 200.

[0092] Balloons to assist weight loss 10:

[0093] The one-way valve 100 prepared in this embodiment is connected to the balloon body 200 prepared in this embodiment by laser welding, so that after being implanted in the stomach, liquid can only enter the balloon body 200 in one direction, so that the balloon 10 can serve as a space-occupying device after the balloon body 200 is inflated.

[0094] Embodiment 2-4

[0095] This embodiment is basically the same as Embodiment 1, except that the concentrations of the polyurethane solution are 10%, 15% and 25%.

[0096] Example 5

[0097] This embodiment is basically the same as Embodiment 1, except that the hardness of the selected polyurethane is 50A.

[0098] Embodiment 6, 7

[0099] This embodiment is basically the same as the embodiment 1, except that during the preparation of the resin film, the thickness of the film applicator is preset to be 0.25 mm and 2 mm respectively.

[0100] Experimental example

[0101] The thickness of the one-way valve prepared in each embodiment was tested, and the softness and hardness were evaluated, and the results were recorded in the following table.

[0102] Table 1 Thickness and hardness evaluation of the one-way valves in various embodiments

[0103]

[0104] *Hardness evaluation method: Touch the transfer valve surface with your hand to evaluate the hardness.

[0105] It can be seen from the above table that each part of the one-way valve provided in each embodiment of the present application is thin and has good flexibility. This indicates that in the preferred solution of the present application, a one-way valve with thin thickness and good flexibility can be obtained by adopting a specific preparation method.

[0106] In summary, the one-way valve for gastric implantation provided by the present application, after being connected to the opening of the balloon body, can allow liquid to enter the balloon body from the liquid inlet channel through the gap between the two resin films. After the liquid continuously enters the balloon body, the balloon body expands. Under the hydraulic pressure inside the balloon body, the two resin films are tightly attached, so that the liquid in the balloon body cannot flow out from between the two resin films, achieving the effect that the liquid can only enter but not exit. The one-way valve provided by the present application is easy to connect to the balloon body due to the design of the specific shape of the umbrella-shaped valve body, so that the arc surface of the umbrella-shaped valve body and the arc surface of the balloon body fit closely. This connection method can make the balloon implanted in the human stomach almost without the feeling of foreign body. In addition, the shape of the umbrella-shaped valve body is easy to manufacture by using a mold to make the solution hang on the wall or coat it into a film, so as to obtain an umbrella-shaped valve body with small thickness and good softness.

[0107] Furthermore, in a preferred manufacturing method, by hanging or coating the solution on the wall and then drying the solution, a one-way valve with an extremely thin wall thickness can be obtained, and a one-way valve with a wall thickness of 0.01 to 0.2 mm can be obtained by using a polyurethane solution with a concentration of 5 to 25% in combination with the above-mentioned preparation method. The umbrella-shaped valve body of this thickness has good softness and is not prone to adverse reactions such as foreign body sensation, gastric ulcer and gastric perforation when implanted in the stomach.

[0108] The balloon for assisting weight loss provided in the present application, after being implanted in the stomach, the liquid in the stomach enters the balloon body and causes the balloon body to continuously expand. The liquid in the expanded balloon will not flow out of the balloon body due to the action of the one-way valve. The expanded balloon occupies a certain space in the stomach, making people feel full all the time, thereby achieving the effect of reducing food intake and thus losing weight.

[0109] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A method for preparing a one-way valve for gastric implantation, characterized in that: Used for preparing a one-way valve, the one-way valve comprising an umbrella-shaped valve body and a check valve, The top of the umbrella-shaped valve body is provided with a liquid inlet, and the umbrella-shaped valve body also has a liquid inlet channel extending from the top of the umbrella-shaped valve body in a direction corresponding to the umbrella handle, and the liquid inlet channel is connected with the liquid inlet. The check valve comprises two laminated resin films, and the opposite side edges of one resin film are connected to the opposite side edges of the other resin film in a one-to-one correspondence. The end of the umbrella-shaped valve body corresponding to the liquid inlet channel is connected to one end of the check valve, so that the liquid inlet channel and the gap between the two resin films are connected; The material of the umbrella-shaped valve body is polyurethane, the hardness of the polyurethane is 50HA~60HD, and the wall thickness of the umbrella-shaped valve body is 0.01~0.2mm; The preparation method comprises: immersing a mold having at least one surface having the same shape as the umbrella-shaped valve body into a first polyurethane solution, taking out the mold and drying it after the surface is completely attached with the first polyurethane solution, and removing the umbrella-shaped valve body obtained after drying from the surface of the mold, wherein the mass concentration of the first polyurethane solution is 5-25%; The resin film is made of polyurethane, the hardness of the polyurethane is 50HA~60HD, the wall thickness of the resin film is 0.01~0.1mm, and one end of the check valve formed by the two edges of the resin film connected is connected to the umbrella-shaped valve body; Alternatively, the two resin films are connected to the umbrella-shaped valve body respectively, and then the edges of the two opposite sides of the two resin films are connected one by one.

2. The preparation method according to claim 1, characterized in that: The edges of the two resin films are connected by laser welding; The check valve and the umbrella-shaped valve body are connected by laser welding.

3. The preparation method according to claim 1, characterized in that: The drying time is at least 12 hours; the drying is carried out in a fume hood.

4. The preparation method according to claim 1, characterized in that: When the mold is immersed in the first polyurethane solution, it is taken as a criterion that no bubbles are generated during the immersion process.

5. The preparation method according to claim 1, characterized in that: The solvent of the first polyurethane solution includes at least one of tetrahydrofuran, dichloromethane, chloroform and hexafluoroisopropanol.

6. The preparation method according to claim 1, characterized in that: Before preparing the umbrella-shaped valve body, the method further includes preparing the first polyurethane solution. The method of preparing the first polyurethane solution is as follows: After mixing the polyurethane with the solvent, dissolve it at a temperature of 10-60°C and a stirring speed of 50-200 r / min; The equipment for preparing the first polyurethane solution is an optional evaporator.

7. The preparation method according to claim 1, characterized in that: The method also includes preparing the resin film, wherein the resin film is prepared by attaching a second polyurethane solution to the surface of a plate-shaped mold, drying the plate-shaped mold, and peeling off the dried resin film from the plate-shaped mold, wherein the mass concentration of the second polyurethane solution is 5-25%; The solvent of the second polyurethane solution includes at least one of tetrahydrofuran, dichloromethane, chloroform and hexafluoroisopropanol; The plate-shaped mold is a glass plate, and the resin film is prepared in the following manner: the second polyurethane solution is poured onto the glass plate of the coating machine, and a coating device with a preset thickness of 0.25-2 mm is used for coating and forming a film. After coating, the glass plate is dried, and the dried resin film is removed from the glass plate; the coating speed is 20-120 cm / min.

8. A balloon for assisting weight loss, characterized in that: It comprises a balloon body with an opening and a one-way valve prepared by the preparation method according to any one of claims 1 to 7 and arranged at the opening, wherein the umbrella-shaped valve body is buckled at the opening, the part of the umbrella-shaped valve body corresponding to the umbrella surface is connected to the outer wall of the balloon body, and the check valve is located inside the balloon body.

9. The balloon for assisting weight loss according to claim 8, characterized in that: The preparation method of the balloon body is as follows: pouring a polyurethane solution with a mass concentration of 5-25% into a spherical mold; After the inner wall of the mold is completely adhered to the polyurethane solution, the spherical mold is inverted, the spherical mold is dried, and the balloon body obtained after drying is taken out from the spherical mold.

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