A collection bottle for collecting liquid samples

Abstract

The present invention provides a collection bottle for collecting liquid samples, comprising a bottle body with an open end, the bottle body comprising an inner wall and an outer wall, the inner wall comprising a cylindrical portion. The bottle body is characterized in that the cylindrical portion of the inner wall of the bottle body is provided with a guide groove extending downward from the opening, the guide groove comprising a portion that slopes downward and spirals downward. Compared to existing technologies, the present invention has a higher liquid sample extrusion rate, making it easier to meet the minimum amount of liquid sample required for testing, thereby improving the success rate of testing and the accuracy of test results.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical devices, and further belongs to the field of medical testing, and in particular relates to a collection bottle for collecting liquid samples. Background Art

[0002] There are a variety of clinical lateral flow immunoassay devices that can be used to detect the presence of analytes in samples, such as hormones, sugars, adulterants, drugs of abuse, etc. Typically, a liquid sample is collected and added to the lateral flow immunoassay device, and then a certain component or components in the liquid sample are detected.

[0003] The liquid sample can be any volume of liquid to be tested, examined or studied. The liquid sample can be derived from any liquid, such as body fluids, such as saliva, blood, urine, or other liquids to be tested, such as water samples from contaminated sources, liquid samples from beverages, etc.

[0004] Liquid samples are usually collected and absorbed using a sampling rod, which has a collecting element formed of an absorbent material such as a pad or sponge, and the collecting element is connected to one end of the plunger. The collecting element allows a sufficient volume of sample liquid to be absorbed from the liquid source, and the presence of the sample liquid in the collecting element causes the interior of the collecting element to swell. The collecting element usually holds the sample until the collecting element is operated to release the sample. During testing, the existing technology usually uses an extrusion method to squeeze the liquid sample out of the collecting element of the sampling rod, and then add it to the detection device (such as a lateral flow immunoassay device) for detection; or in some tests, the squeezed liquid sample needs to be mixed / lysed with a buffer solution and other pretreatments before being added to the detection device for detection.

[0005] In existing operations, a collection bottle is used to collect the liquid sample on the collection element. That is, the collection element end of the sampling stick is inserted into the collection bottle, and the collection element is pressed against the side wall or bottom of the collection bottle body to make the liquid sample flow out into the collection bottle for sample collection. A problem with existing collection bottles and sampling sticks is that the liquid sample on the collection element of the sampling stick cannot be fully squeezed out. That is, after squeezing, a large amount of liquid sample still remains on the collection element, so that only a small amount of liquid sample is used for subsequent testing. This can easily result in insufficient amount of liquid sample for testing, resulting in test failure or inaccurate test results (especially when the liquid sample is saliva. Generally, the amount of saliva that a human or animal can release in a short period of time is very limited, which can easily lead to insufficient amount of liquid sample). In addition, when there is a buffer solution in the collection bottle, the collection element will also absorb and carry away part of the buffer solution or the mixture of the liquid sample and the buffer solution, thereby affecting the accuracy of the test results. Summary of the Invention

[0006] One of the purposes of the present invention is to provide a collection bottle for collecting liquid samples to address the deficiencies of the prior art, and to collect liquid samples from humans or animals.

[0007] The above-mentioned object of the present invention is achieved through the following technical solutions:

[0008] A collection bottle for collecting liquid samples includes a bottle body with an opening, the bottle body includes an inner wall and an outer wall, the inner wall includes a cylindrical portion, wherein: the cylindrical portion of the inner wall of the bottle body is provided with a guide groove extending downward from the opening, and the guide groove includes a portion that is inclined from top to bottom and spirally descends.

[0009] As a further improvement of the present invention, the cross section of the guide groove is rectangular, triangular, trapezoidal or arc-shaped, and the portion with a larger cross section of the guide rail is located on the inner wall of the bottle body.

[0010] As a further improvement of the present invention, after the inner wall of the bottle body is unfolded, the guide groove includes a vertical portion and an inclined portion from top to bottom.

[0011] As a further improvement of the present invention, after the inner wall of the bottle body is unfolded, the inclined portion of the guide groove is a straight line or a smooth curve.

[0012] As a further improvement of the present invention, the slope of the smooth curve decreases from top to bottom.

[0013] As a further improvement of the present invention, the guide groove further includes a horizontal surrounding portion connected to the bottom of the inclined portion of the guide groove.

[0014] As a further improvement of the present invention, it further comprises a pad placed in the bottle body, wherein the pad is provided with a through hole for facilitating the passage of the liquid sample.

[0015] As a further improvement of the present invention, the upper surface of the pad is provided with a protrusion or a depression.

[0016] As a further improvement of the present invention, the guide rail spirally descends from one-sixth to one full circle of the inner wall of the bottle body.

[0017] A second object of the present invention is to address the deficiencies of the prior art and provide a liquid sample collection device for collecting liquid samples from humans or animals.

[0018] The above-mentioned object of the present invention is achieved through the following technical solutions: a liquid sample collection device, comprising a collection bottle for collecting liquid samples and a sampler, wherein the collection bottle for collecting liquid samples comprises a bottle body with an opening, the bottle body comprises an inner wall and an outer wall, the inner wall comprises a cylindrical portion, the sampler comprises a rod portion and a liquid drawing portion, the liquid drawing portion is connected to the lower end of the rod portion, wherein: the cylindrical portion of the inner wall of the bottle body is provided with a guide groove extending downward from the opening, the guide groove comprises a portion inclined from top to bottom and spirally descending, the lower end of the rod portion is provided with a guide rail, after the lower end of the rod portion of the sampler is inserted into the collection bottle for collecting liquid samples, the guide rail at the lower end of the rod portion cooperates with the guide groove on the inner wall of the bottle body to guide the lower end of the rod portion of the sampler to spirally descend in the collection bottle for collecting liquid samples.

[0019] As a further improvement of the present invention, the cross section of the guide groove on the inner wall of the bottle body is rectangular, triangular, trapezoidal or arc-shaped, and the portion with a larger cross section of the guide rail is located on the inner wall of the bottle body.

[0020] As a further improvement of the present invention, after the inner wall of the bottle body of the collection bottle for collecting the liquid sample is unfolded, the guide groove includes a vertical portion and an inclined portion from top to bottom.

[0021] As a further improvement of the present invention, after the inner wall of the bottle body of the collection bottle for collecting the liquid sample is unfolded, the inclined portion of the guide groove is a straight line or a smooth curve.

[0022] As a further improvement of the present invention, the slope of the smooth curve decreases from top to bottom.

[0023] As a further improvement of the present invention, the guide groove further includes a horizontal surrounding portion connected to the bottom of the inclined portion of the guide groove.

[0024] As a further improvement of the present invention, it also includes a pad placed in the collection bottle for collecting liquid samples, and the pad is provided with a through hole for facilitating the passage of the liquid sample, so that the liquid-drawing part of the sampler can be squeezed when the lower end of the rod of the sampler spirals down in the collection bottle for collecting liquid samples.

[0025] As a further improvement of the present invention, the pad and the liquid-drawing portion of the sampler are provided with mutually matching protrusions and depressions.

[0026] As a further improvement of the present invention, the bottom of the liquid-drawing part is hardened so that it has a higher hardness than other parts of the liquid-drawing part, thereby being more conducive to reducing the slippage between the bottom of the liquid-drawing part and the upper surface of the pad.

[0027] As a further improvement of the present invention, the guide groove spirally descends to one-sixth to one full circle of the inner wall of the bottle body of the collection bottle for collecting the liquid sample.

[0028] As a further improvement of the present invention, the guide rails and guide grooves that cooperate with each other form a pair, or are evenly distributed in two, three, four, five or six pairs.

[0029] The third purpose of the present invention is to provide a method for collecting liquid samples for collecting liquid samples from humans or animals in response to the deficiencies of the prior art.

[0030] The above-mentioned object of the present invention is achieved through the following technical solutions:

[0031] A method for collecting a liquid sample is provided, wherein a liquid sample collecting device is provided, the liquid sample collecting device comprising a sampler and a liquid sample collecting component, wherein an inclined and spirally descending guide mechanism is provided between the sampler and the liquid sample collecting component for guiding the sampler to spirally descend within the liquid sample collecting component. The method comprises the following steps:

[0032] A. Allow the sampler's liquid drawing portion to draw a predetermined amount of liquid sample;

[0033] B. Insert the liquid-drawing portion of the sampler into the liquid sample collecting component so that the inclined guide rail of the sampler corresponds to the inclined and spirally descending guide groove on the inner wall of the liquid sample collecting component;

[0034] C. Push the sampler downward. Under the guidance of the guide groove and the guide rail, the sampler spirally descends in the liquid sample collection component, thereby squeezing the liquid-absorbing part of the sampler until the liquid-absorbing part is fully squeezed;

[0035] D. Make the sampler spiral upward in the reverse direction, remove the sampler, and seal the liquid sample collection component.

[0036] As a further improvement of the present invention, the liquid sample collection device is as disclosed in the second embodiment of the present invention.

[0037] A fourth object of the present invention is to provide a detection device for collecting liquid samples from humans or animals in response to the deficiencies of the prior art.

[0038] The above-mentioned object of the present invention is achieved through the following technical solutions:

[0039] A detection device includes a liquid sample collection device and a detection plate. The liquid sample collection device includes a liquid sample collection component and a sampler, wherein the liquid sample collection component includes a cylindrical inner wall, and the sampler includes a rod and a liquid drawing part, wherein the liquid drawing part is connected to the lower end of the rod, wherein: the cylindrical part of the inner wall of the bottle body is provided with a guide groove extending downward from the opening, and the guide groove includes a part that tilts from top to bottom and spirally descends, and the lower end of the rod is provided with a guide rail. After the lower end of the rod of the sampler is inserted into a collection bottle for collecting liquid samples, the guide rail at the lower end of the rod cooperates with the guide groove on the inner wall of the bottle body to guide the lower end of the rod of the sampler to spirally descend in the collection bottle for collecting liquid samples, and then squeeze the liquid drawing part of the sampler. The detection plate includes a detection component, and the detection component is used to provide detection result information.

[0040] As a further improvement of the present invention, the liquid sample collecting component and the detection plate or a component of the detection plate are independent elements separated from each other.

[0041] As a further improvement of the present invention, the liquid sample collecting component is installed on the detection plate or a component of the detection plate.

[0042] Beneficial effects

[0043] The present invention provides a guide groove extending downward from an opening on the inner wall of a collection bottle for collecting liquid samples. The guide groove includes a portion that tilts and spirals downward from top to bottom. A guide rail is provided at the lower end of the sampling rod. After the sampler's liquid-drawing portion has drawn sufficient liquid sample, it is inserted into the sampling bottle. Under the cooperation of the guide rail and the guide groove, the lower end of the sampler's rod is guided to drive the liquid-drawing portion to perform a spiral downward motion within the sampling bottle, thereby producing a squeezing effect on the liquid-drawing portion, thereby fully squeezing out the liquid sample drawn by the liquid-drawing portion. Compared with the prior art, the present invention has a higher liquid sample extrusion rate. When the liquid-drawing portion draws the same liquid sample, more liquid sample can be squeezed out for testing, thereby more easily meeting the minimum amount of liquid sample required for testing, thereby improving the success rate of testing and the accuracy of the test results. BRIEF DESCRIPTION OF THE DRAWINGS

[0044] Figure 1 It is a schematic plan view of a collecting bottle for collecting liquid samples according to the present invention.

[0045] Figure 2 for Figure 1 Schematic diagram of the cross section along line AA.

[0046] Figure 3 This is a schematic plan view of a pad in a collection bottle for collecting liquid samples according to the present invention.

[0047] Figure 4 for Figure 1 Top view of .

[0048] Figure 5 Schematic diagram of a plan view of the liquid sample collecting device of the present invention (the sampler is not inserted into the collecting bottle for collecting the liquid sample).

[0049] Figure 6 for Figure 5 Schematic diagram of the local section along line AA.

[0050] Figure 7 and Figure 5 Similar, but the sampler is inserted into the collection bottle to collect the liquid sample in the initial position (the water-absorbing part has not yet been squeezed).

[0051] Figure 8 for Figure 7 Schematic diagram of the cross section along line AA.

[0052] Figure 9 for Figure 8 A partial enlarged schematic diagram of section "A" along the CC direction.

[0053] Figure 10-12 for Figure 9 Schematic diagram of the design change.

[0054] Figure 13 It is a partially expanded plan view of the cylindrical portion of the inner wall of the collection bottle for collecting liquid samples of the present invention.

[0055] Figure 14 yes Figure 13 Schematic diagram of the design change.

[0056] Figure 15 and Figure 7 Similar, but the probe is inserted into its final position (the wicking part is fully squeezed) in the collection bottle where the liquid sample is collected.

[0057] Figure 16 for Figure 15 Schematic diagram of the cross section along line AA.

[0058] Figure 17 for Figure 2 Schematic diagram of the design change.

[0059] Figure 18 and Figure 7 Similar, but the collection bottle for liquid samples has Figure 17 The structure shown.

[0060] Figure 19 for Figure 18 An enlarged schematic diagram of the local “B” in FIG.

[0061] Figure 20 for Figure 8The modified design diagram shows another modified design of the present invention.

[0062] Figure 21 for Figure 20 A partial enlarged schematic diagram is shown in the figure.

[0063] Figure 22 for Figure 21 Change design drawing.

[0064] Figure 23-28 These are six specific embodiments of the sampling rod of the present invention.

[0065] Figure 29 、 Figure 30 for Figure 13 Change design drawing.

[0066] Figure 31 、 Figure 32 for Figure 14 Change design drawing.

[0067] Figure 33 Schematic diagram of the detection device of the present invention in use.

[0068] Figure 34 for Figure 33 Schematic diagram of the test results of the test board shown.

[0069] Figure 35 This is a schematic diagram of another embodiment of the detection device of the present invention in use.

[0070] Figure 36 for Figure 35 Schematic diagram of the test results of the test board shown. DETAILED DESCRIPTION

[0071] The present invention will be described in further detail with reference to the accompanying drawings and specific embodiments.

[0072] The above-mentioned specific implementation methods are used to illustrate the present invention and are only preferred embodiments of the present invention, rather than limiting the present invention. Any modifications, equivalent substitutions, improvements, etc. made to the present invention within the spirit of the present invention and the scope of protection of the claims shall fall within the scope of protection of the present invention.

[0073] Interpretation of terms: If the patent specification (including claims and abstract) of this invention provides an explanation of the terms used, the interpretation of this patent specification shall prevail. If there is no explanation, the general meaning in this technical field shall prevail.

[0074] Cylinder: The cylinder of the present invention refers to a cylindrical object with a circular or approximately circular cross-section, and with equal or approximately equal areas across all cross-sections. The cylinder of the present invention also includes a cone with its tip truncated, i.e., a cone with a longitudinal section passing through its axis that is an isosceles trapezoid or a nearly isosceles trapezoid, but preferably, the angle between the hypotenuse and the height of the trapezoid does not exceed 15 degrees. In short, any cylindrical object deemed by those skilled in the art to be capable of achieving the objectives of the present invention, resolving the technical problems to be solved, and achieving the beneficial effects of the present invention is included within the scope of the cylinder of the present invention.

[0075] Cylindrical portion: The portion having the shape or structure of a cylinder of the present invention.

[0076] Collection bottle for collecting liquid samples: also known as liquid sample collection component, refers to a bottle-shaped object, cup-shaped object, cylindrical object, and any object or part of an object with a cylindrical inner wall for collecting liquid samples.

[0077] Spiral descent: Also known as spiral descent, this is a 3D, smooth curve that gradually descends from a high point to a low point on the inner wall of a cylinder. The spiral can range from a fraction of a turn to a full turn or several turns.

[0078] Rectangle, triangle, trapezoid: includes both the mathematical concept of rectangle, triangle, trapezoid and approximate rectangle, triangle and trapezoid.

[0079] Forward: refers to the direction opposite to reverse, but forward does not specifically refer to clockwise, but refers to either clockwise or counterclockwise. When forward refers to clockwise, reverse refers to counterclockwise; conversely, when forward refers to counterclockwise, reverse refers to clockwise.

[0080] Twisting: squeezing and twisting at the same time, that is, the two ends of an object move closer to each other while also rotating in opposite directions, producing an effect similar to wringing a wet towel.

[0081] The liquid-drawing part is fully squeezed: this means that the liquid-drawing part is squeezed under normal human power to achieve the effect of basically draining the liquid in the liquid-drawing part (the liquid drainage rate is significantly higher than that of the prior art).

[0082] See also Figure 1 、 Figure 2As shown, the present invention provides a collection bottle 10 for collecting liquid samples, which is used to collect liquid samples such as saliva, blood, urine, and sweat from humans or animals. After processing, the content of certain substances in these liquid samples is detected using biological detection methods (including immunological and non-immunological detection methods), thereby obtaining physiological parameter indicators of the human or animal being tested. Currently, scientists have developed products and detection methods for testing human or animal saliva (including after processing). One of the key aspects of such detection methods is how to collect saliva from the human or animal being tested. The purpose of the present invention is to provide a new collection bottle for collecting liquid samples of human or animal saliva, a liquid sample collection device, and a method for collecting liquid samples using such a liquid sample collection device.

[0083] Invention 1: Collection bottle for collecting liquid samples

[0084] See also Figure 1 、 Figure 2 As shown, the collection bottle 10 for collecting liquid samples of the present invention includes a bottle body 12 with an opening 11. The bottle body 12 includes an inner wall 14 and an outer wall 16. The inner wall 14 includes a cylindrical portion 18 (i.e., at least a portion of the inner wall 14 is a cylindrical structure). The cylindrical portion 18 is provided with a guide groove 20 that is inclined and spirally descends from the top to the bottom from the opening 11. The guide groove 20 that is inclined and spirally descends from the top to the bottom of the present invention includes at least the following structures: A. The entire section from the starting point to the end point is a spirally descending portion 20b (e.g., Figure 29 、 Figure 31 B, a vertical descending portion 20a extending vertically downward from the opening 11 of the bottle body for an appropriate distance and a spiral descending portion 20b communicating with the vertical descending portion 20a (as shown); Figure 2 、 6 , 13, 14); C, a vertical descending portion 20a extending vertically downward from the opening 11 of the bottle body for an appropriate distance, a spiral descending portion 20b communicating with the vertical descending portion 20a, and a horizontal surrounding portion 20c communicating with the spiral descending portion 20b (as shown in FIG. Figure 17 and D, the spiral descending portion 20b spirally descending from the opening 11 of the bottle and the horizontal surrounding portion 20c communicating with the spiral descending portion 20b (as shown); Figure 30 、 32 As shown). The guide groove 20 is a groove recessed into the inner wall 14 by an appropriate distance and attached to the inner wall 14 in a spiral shape. Figure 9-12 As shown, the cross section of the guide groove 20 is rectangular (including square), triangular, trapezoidal or arc-shaped (including partially circular or partially elliptical), and the portion of the guide groove 20 with a larger cross section (such as Figure 9-12 The inner wall 14 of the bottle body 12 is shown as the dotted line in FIG.

[0085] In one embodiment, after the cylindrical portion 18 of the inner wall 14 of the bottle body 12 is unfolded, the spiral descending portion 20b on the inner wall 14 is a straight line inclined from top to bottom (e.g. Figure 13 、 29 , 31), at this time, the angle "A" between the inner wall 14 and the horizontal plane is greater than or equal to 30 degrees and less than or equal to 75 degrees, and the preferred angle "A" is 60 degrees or 45 degrees. In another embodiment, after the inner wall 14 of the bottle body 12 is unfolded, the spiral descending portion 20b on the inner wall 14 is a smooth curve inclined from top to bottom (as shown in FIG. Figure 14 、 31 , 32 ), at this time, the slope of the smooth curve decreases from top to bottom (i.e., the angle between the tangent of the smooth curve and the horizontal plane gradually decreases). In this embodiment, preferably, the angle "C" between the tangent of the top of the guide groove 20 and the horizontal plane is 75 degrees, and the angle "B" between the tangent of the bottom of the guide groove 20 and the horizontal plane is 30 degrees.

[0086] like Figure 2 As shown, the collection bottle 10 for collecting liquid samples further includes a pad 22 placed in the bottle body 12. The pad 22 is provided with a plurality of through holes 24 for facilitating the flow of the liquid sample. The pad 22 is disc-shaped and has a thickness of about 2.0-5.0 mm and is generally made of hard plastic. Figure 1 and Figure 2 In the illustrated embodiment, the bottle body 12 comprises an upper portion and a lower portion. The upper portion is significantly larger than the lower portion, and a shoulder 26 is formed at the junction of the two portions. A backing plate 22 is placed on and supported by the shoulder 26. In one embodiment, when the area of ​​the shoulder 26 is twice or greater than the cross-sectional area of ​​the inner diameter of the lower portion of the bottle body, the backing plate 22 may be omitted, i.e., the backing plate 22 is not required. Figure 3 is a plan view of the pad 22, Figure 4 2 is a top view of the backing plate 22 after being placed in the bottle body 12. In one embodiment, the upper surface of the backing plate 22 is provided with a depression (the depression can also be a through hole 24, such as Figure 21 as shown) or raised (as Figure 22 As shown). The guide groove 20 spirals down at least one-sixth of the inner wall 18 of the bottle body, but preferably does not exceed one full circle (it does not necessarily have to exceed one full circle; in some cases, it may be several full circles). A single guide groove 20 may be provided on the inner wall 18 of the cylindrical portion, or two, three, four, five, or six guide grooves 20 may be evenly distributed. However, the number of guide grooves 20 does not limit the scope of protection of the present invention.

[0087] Invention 2: Liquid Sample Collection Device

[0088] See also Figure 5-8As shown, the present invention also provides a liquid sample collection device 100, which includes a collection bottle 10 for collecting liquid samples as described in Invention 1 (to avoid repetition, the contents of Invention 1 are all incorporated into Invention 2) and a sampler 50. The sampler 50 includes a rod 52 and a liquid-drawing portion 56 connected to the lower end 54 of the rod. The liquid-drawing portion 56 is made of a material with excellent water absorption and drainage properties, such as sponge, cotton wool, gauze, special fibers, etc. The rod 52 is made of a hard material, and the lower end 54 of the rod is in the shape of a round cake, and a protruding guide rail 58 is provided on its outer periphery. The shape and size of the guide rail 58 correspond to the guide groove 20 on the inner wall 14 of the bottle body ( Figure 5 and Figure 6 The guide rail 58 is shown to be inclined, and its inclination direction is consistent with that of the guide groove 20. This allows the guide rail 58 to slide freely within the guide groove 20 while also cooperating to guide the lower end 54 of the rod in a spiral downward motion. When the lower end 54 of the rod of the sampler 50 is inserted into the collection bottle 10 for collecting a liquid sample, the guide rail 58 of the lower end 54 of the rod cooperates with the guide groove 20 on the inner wall 14 of the bottle, guiding the lower end 54 of the rod of the sampler 50 in a spiral downward motion within the collection bottle for collecting the liquid sample. When the bottom of the liquid-drawing portion 56 presses against the upper surface of the pad 22, the surface friction between the two reduces the relative sliding of the bottom of the liquid-drawing portion 56 relative to the pad 22. However, the guide groove 20 guides the lower end 54 of the rod to drive the upper part of the liquid-drawing portion 56 to continue to twist and descend, so that the lower end 54 of the rod presses downward while twisting the liquid-drawing portion 56, producing an effect of twisting the liquid-drawing portion 56 (similar to twisting a wet towel), thereby more thoroughly draining the liquid sample from the liquid-drawing portion 56 into the collection bottle 10 for collecting the liquid sample, and mixing with the lysate 60 (such as Figure 8 ) to form a mixture of lysate and liquid sample 62 (as shown Figure 16 shown).

[0089] As described in the first aspect of the present invention, after the cylindrical portion 18 of the inner wall 14 of the bottle body 12 is unfolded, at least a portion of the guide groove 20 on the inner wall 14 is formed into a straight line or a smooth curve 20b that slopes downward from top to bottom. The smooth curve of the guide groove facilitates the guide groove 20 and the guide rail 58 to guide the lower end 54 of the rod to accelerate its descent at the beginning of the descent, thereby exerting a stronger downward pressure on the liquid-drawing portion. Furthermore, near the end of the descent, the guide groove 20 and the guide rail 58 guide the lower end 54 of the rod to exert a stronger twist, thereby achieving a better squeezing effect on the liquid-drawing portion 56 and squeezing out more liquid sample from the liquid-drawing portion 56.

[0090] like Figure 20-22As shown, in order to reduce the relative slip between the bottom of the liquid-drawing portion 56 and the upper surface of the backing plate 22, mutually cooperating protrusions 28 and recesses 30 are provided on the upper surface of the backing plate 22 and the bottom of the liquid-drawing portion 56 of the sampler. The cooperation between the protrusions and recesses reduces the relative slip between the bottom of the liquid-drawing portion 56 and the upper surface of the backing plate 22, thereby enhancing the squeezing effect on the liquid-drawing portion 56. The recesses 30 (which may also be through-holes 24) may be provided on the upper surface of the backing plate 22 and the protrusions 28 (such as through-holes 24) may be provided on the bottom of the liquid-drawing portion 56 of the sampler. Figure 21 As shown), a protrusion 28 may be provided on the upper surface of the pad 22 and a recess 30 may be provided at the bottom of the liquid drawing portion 56 of the sampler (as shown). Figure 22 Preferably, the bottom of the liquid-drawing portion 56 is hardened to have a higher hardness than other portions of the liquid-drawing portion. This further helps reduce slippage between the bottom of the liquid-drawing portion 56 and the upper surface of the backing plate 22, thereby improving the squeezing effect of the liquid-drawing portion 56 and thereby increasing the liquid sample discharge rate of the liquid-drawing portion 56.

[0091] like Figure 23 As shown, the guide rail 58 on the lower end 54 of the rod of the sampler 50 is one, and the guide groove 20 and the guide rail 58 that cooperate with each other are a pair. Figures 24-28 As shown, in order to improve the smoothness of the guidance, the guide rails 58 on the lower end 54 of the rod of the sampler 50 can also be evenly distributed in the form of two, three, four, five or six pairs. In this case, the guide grooves 20 and the guide rails 58 that cooperate with each other are respectively two pairs, three pairs, four pairs, five pairs or six pairs. This can improve the squeezing effect of the liquid drawing part 56 and further improve the efficiency of squeezing the liquid sample out of the liquid drawing part 56.

[0092] like Figure 17-19 As shown, the distance "L" between the bottom of the horizontal surrounding portion 20c of the guide groove and the upper surface of the backing plate 22 is greater than or equal to 2.5 mm and less than or equal to 35.0 mm. This distance "L" can keep the guide rail 58 of the lower end 54 of the rod portion of the sampler 50 locked in the horizontal surrounding portion 20c (as shown in FIG. Figure 17 、 18 At this time, the liquid drawing portion 56 is in a twisted and compressed state.

[0093] The liquid sample collection bottle 10 of the present invention can also be integrated with a detection device (not shown; the specific structure of the detection device is the same as in the prior art and will not be further described herein) (including the two being formed integrally or separately and then assembled into one). In other words, the liquid sample collection bottle 10 of the present invention can be incorporated into an existing detection device, making it the liquid sample receiving portion of the detection device. Alternatively, a guide groove 20 as described herein can be provided on the cylindrical inner wall of the liquid sample receiving portion of an existing detection device. This guide groove 20 cooperates with the guide rail 58 at the lower end of the sampler 10 to guide the liquid draw portion 56 of the sampler 10 in a twisting motion, thereby improving the liquid sample removal rate of the liquid draw portion 56. In other words, the liquid sample collection bottle 10 of the present invention can be a stand-alone bottle-like structure or part of the sample receiving portion of a detection device.

[0094] Invention 3: A method for collecting liquid samples

[0095] The present invention also provides a method for collecting a liquid sample, comprising a liquid sample collecting component 10 and a sampler 50, wherein an inclined and spirally descending guide mechanism is provided between the liquid sample collecting component 10 and the sampler 50 for guiding the sampler 50 to spirally descend within the liquid sample collecting component 10. The method comprises the following steps:

[0096] A. Allow the liquid drawing portion 56 of the sampler 50 to draw a predetermined amount of liquid sample;

[0097] B. Insert the lower end 54 of the sampler rod into the liquid sample collecting component 10 to form the guiding mechanism therebetween;

[0098] C. Push the sampler 50 downward. Under the guidance of the guide mechanism, the liquid-drawing portion 56 of the sampler spirally descends in the collecting bottle 10 for collecting the liquid sample, thereby squeezing the liquid-drawing portion 56 of the sampler until the liquid-drawing portion 56 is fully squeezed.

[0099] D. Make the sampler 50 spiral upward in the reverse direction, take out the sampler 50, and seal the collection bottle 10 for collecting the liquid sample.

[0100] As a further improvement, the guiding mechanism includes a guide rail 20 and a guide groove 58 (or a guide groove 20 and a guide rail 58 ) respectively provided at the lower ends of the rods of the liquid sample collecting component 10 and the sampler 50 .

[0101] Invention 4: A detection device

[0102] Figure 33 、 34The figure shows the use and test results of a detection device according to the present invention. The detection device 200 includes a liquid sample collection device 100 (the structure is similar to that described in "Invention 2," except for the addition of a cap 11) and a detection plate 210. The liquid sample collection device 100 comprises a liquid sample collection component 10 and a sampler 50. The liquid sample collection component 10 includes a cylindrical inner wall 14. The sampler 50 comprises a stem 52 and a liquid-drawing portion 56 connected to the stem's lower end 54. The cylindrical inner wall 14 is provided with a guide groove 20 that slopes downward and spirals downward, and the stem's lower end 54 is provided with a guide rail 58. After the stem's lower end 54 is inserted into the liquid sample collection component 10, the guide rail 58 cooperates with the guide groove 20 in the cylindrical inner wall, guiding the stem's lower end 54 as it spirals downward within the liquid sample collection component 10, thereby squeezing the sampler's liquid-drawing portion 56. The detection board 210 includes a detection component 220, which is used to give the detection result information. The detection board 210 is provided with a sample addition area 212 and a detection result display area 214 to facilitate observation of the detection results. The detection component 220 has a T line and a C line in the detection result display area 214. Before the detection, the T line and the C line are invisible. Within a period of time after the detection, the following situations will generally occur: A. If the C line is not displayed (regardless of whether the T line is displayed), it means that the test has failed; B. If the C line is displayed but the T line is not displayed, it means that the test result is negative; C. If both the C line and the T line are displayed, it means that the test result is positive, and if the T line is thick, it is a strong positive, and if the T line is light, it is a weak positive. In such cases Figure 33 、 34 In the illustrated embodiment, the liquid sample collecting component 10 and the detection plate 210 or components of the detection plate 210 are independent components separated from each other, and the structures of the liquid sample collecting component 10 and the sampler 50 are basically the same as those of the "Invention 2".

[0103] Figure 35 、 36 It shows the use status and detection results of another detection device 200 of the present invention. Figure 33 、 34The difference in the illustrated embodiment is that the liquid sample collection component 10 is mounted on the test plate 210 or a component of the test plate 210. The liquid sample collection component 10 and the test plate 210 or a component of the test plate 210 can be manufactured separately and then assembled together, or they can be integrally molded with the test plate 210 or a component of the test plate 210 and then assembled together to form a single unit. The cylindrical inner wall 14 of the liquid sample collection component 10 is provided with a guide groove 20 that slopes downward and spirals downward. The lower end 54 of the rod is provided with a guide rail 58. After the lower end 54 of the sampler rod is inserted into the liquid sample collection component 10, the guide rail 58 cooperates with the guide groove 20 on the cylindrical inner wall to guide the lower end 54 of the sampler rod as it spirals downward within the liquid sample collection component 10, thereby squeezing the sampler's liquid-drawing portion 56. The basic principle and specific structure are as disclosed in "Invention 2."

[0104] experiment

[0105] The present invention uses a sponge swab as an example of the sampler 50 to collect human saliva, and uses a comparative experimental method to verify the beneficial effects of the present invention.

[0106] Experimental methods:

[0107] Step 1: Use 10 sponge swabs of the present invention, numbered 1-10, and weigh each sponge swab before drawing the liquid using an electronic scale accurate to one thousandth of a gram. Record the weight in column "A" in the table below (weights are in grams, the same below).

[0108] Step 2: Use the 10 sponge swabs to collect saliva from 10 volunteers. Once the sponge tips are saturated, weigh each sponge swab and record the weight in column "B" in the table below.

[0109] Step 3: Insert each of the 10 sponge swabs into the existing liquid sample collection bottle. Squeeze the sponge tip vertically downward to fully squeeze out the saliva. Weigh each sponge tip and record the weight in column "C" in the table below.

[0110] Step 4: Insert the ten sponge swabs obtained after step 3 into the liquid sample collection bottle of the present invention. After fully squeezing out the saliva from the sponge tips using the method of the present invention, weigh the sponge tips and record the weight in the "D" column of the table below.

[0111] Step 5: Use the formulas in the table below to calculate the amount of liquid drawn up by the 10 sponge swabs (E), the amount of sample squeezed out using the existing method (F), the amount of sample squeezed out using the method of the present invention (G), the percentage of sample squeezed out using the existing method (H), the percentage of sample squeezed out using the method of the present invention (I), and the percentage improvement of the present invention over the existing method (J).

[0112] Step 6: Calculate the average value of the percentage improvement of the present invention relative to the existing method.

[0113]

[0114] Table 1. Comparative experimental data of existing sampling method and sampling method of the present invention

[0115] According to the experimental data in Table 1, the sampling method of the present invention increases the sampling volume by an average of 28.67% compared with the existing sampling method. This experiment shows that the beneficial effects of the sampling device and sampling method of the present invention are very outstanding.

[0116] In biological sample testing procedures, the sample collection bottle of the present invention, when used in conjunction with a sampling stick, can fully collect the sample from the stick and simultaneously complete pre-processing steps such as sample lysis. This improves the utilization rate of sampled specimens in testing projects requiring sample collection with a sampling stick, such as those for allergens, tumor markers, gonadal markers, thyroid function markers, infectious disease markers, diabetes markers, and liver fibrosis markers.

Claims

1. A collection bottle for collecting liquid samples, comprising a bottle body with an open end, the bottle body comprising an inner wall and an outer wall, the inner wall comprising a cylindrical portion, characterized in that: The cylindrical portion of the inner wall of the bottle body is provided with a guide groove extending downward from the opening, wherein the guide groove includes a vertical portion and a portion that is inclined and spirally descending from top to bottom. When the inner wall of the bottle body is unfolded into a plane, the portion that is inclined and spirally descending from top to bottom includes a smooth curve, and the angle between the tangent of the smooth curve and the horizontal plane is greater than or equal to thirty degrees and less than or equal to seventy-five degrees, and the slope of the smooth curve decreases from top to bottom.

2. The collection bottle for collecting liquid samples according to claim 1, characterized in that: The angle "C" between the tangent line of the top of the smooth curve of the guide groove and the horizontal plane is seventy-five degrees, and the angle "B" between the tangent line of the bottom of the smooth curve of the guide groove and the horizontal plane is thirty degrees.

3. A collection bottle for collecting liquid samples according to claim 1 or 2, characterized in that: The guide groove further includes a horizontal surrounding portion communicating with the bottom of the smooth curve of the guide groove.

4. The collection bottle for collecting liquid samples according to claim 3, characterized in that: The bottle also includes a backing plate placed in the bottle body, wherein the backing plate is provided with a through hole for facilitating the passage of the liquid sample.

5. The collection bottle for collecting liquid samples according to claim 4, characterized in that: The upper surface of the pad is provided with a protrusion or a depression.

6. The collection bottle for collecting liquid samples according to claim 5, characterized in that: The spiral descending portion of the guide groove occupies one sixth to one full circumference of the inner wall of the bottle body.

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