Personal care compositions

Abstract

Described herein are personal care compositions that include, among other things, a gum system including a plurality of natural gums; a surfactant system including a plurality of alkyl polyglucoside surfactants; and a cosmetically acceptable carrier. Also described herein are methods of making and using these compositions.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This application claims the benefit of priority to U.S. Provisional Application No. 62 / 884,472, filed on August 8, 2019, the contents of which are hereby incorporated by reference in their entirety. Background Art

[0003] Prebiotics are known to have beneficial effects on skin health. However, many currently available personal care products contain artificial ingredients; and have difficulty providing adequate lather and the desired prebiotic benefits.

[0004] Therefore, there remains a need for natural personal care products that provide an adequate level of lather while also providing a meaningful prebiotic effect. Certain embodiments of the present invention are designed to meet these and other needs. Summary of the invention

[0005] Some embodiments of the present invention provide personal care compositions comprising: a gum system comprising a plurality of natural gums; a surfactant system comprising a plurality of alkyl polyglucoside surfactants; and a cosmetically acceptable carrier.

[0006] Other embodiments of the present invention provide personal care compositions comprising: a prebiotic agent; a polysaccharide gum; and a cosmetically acceptable carrier.

[0007] Further embodiments of the present invention provide methods for cleansing keratinous surfaces of a subject in need thereof, comprising applying a personal care composition according to any preceding claim to the keratinous surfaces of the subject.

[0008] Further areas of applicability of the present invention will become apparent from the detailed description provided hereinafter.It should be understood that the detailed description and specific examples, while indicating the preferred embodiment of the invention, are intended for purposes of illustration only and are not intended to limit the scope of the invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0009] Figure 1 Selective inhibition of bacteria provided by certain prebiotic ingredients is described.

[0010] Figure 2 The selective inhibition of bacteria provided by an exemplary body wash of the present invention and a conventional body wash is depicted.

[0011] Figure 3 Depicted are the results of barrier function testing conducted in an ex vivo skin tissue model using an exemplary body wash of the present invention and a conventional body wash.

[0012] Figure 4 Depicted are the results of a fluorescent yellow dye penetration assay of an exemplary body wash of the present invention and a conventional body wash. DETAILED DESCRIPTION

[0013] For illustrative purposes, the principles of the present invention are described by reference to various exemplary embodiments of the present invention. Although certain embodiments of the present invention are specifically described herein, it will be readily appreciated by those of ordinary skill in the art that the same principles are equally applicable and can be adopted in other devices and methods. Before explaining the disclosed embodiments of the present invention in detail, it should be understood that the application of the present invention is not limited to the details of any particular embodiment shown. The terms used herein are for description rather than limitation.

[0014] As used herein and in the appended claims, the singular forms "a", "an", and "the" include plural references unless the context dictates otherwise. The singular form of any class of components refers not only to one chemical species within that class, but also to mixtures of these chemical species. The terms "a" (or "an"), "one or more", and "at least one" are used interchangeably herein. The terms "including", "comprising", and "having" are used interchangeably. The term "include" should be interpreted as "including, but not limited to". The term "including" should be interpreted as "including, but not limited to".

[0015] Ranges used throughout are used as a shorthand way of describing each value within the range. Any value within the range can be selected as the endpoint of the range.

[0016] When referring to a number, the term "about" refers to any number within 10% of the number. For example, the expression "about 2.0 wt %" refers to a number between and including 1.800 wt % and 2.200 wt %.

[0017] All references cited herein are incorporated herein by reference in their entirety. In the event of a conflict in a definition in the present disclosure and that of a cited reference, the present disclosure controls.

[0018] Unless otherwise indicated, the abbreviations and symbols used herein have their usual meanings. The abbreviation "wt%" refers to the weight percentage relative to the personal care composition. The symbol "°" refers to degrees, such as temperature degrees or angle degrees. The symbols "h", "min", "mL", "nm", "μm" refer to hours, minutes, milliliters, nanometers and micrometers, respectively. The abbreviation "UV-VIS" when referring to a spectrometer or spectroscopy refers to ultraviolet-visible. The abbreviation "rpm" refers to revolutions per minute.

[0019] When referring to chemical structures and names, the symbols "C", "H", and "O" refer to carbon, hydrogen, and oxygen, respectively. The symbols "–", "=", and "≡" refer to single, double, and triple bonds, respectively.

[0020] Any member of a species list used to exemplify or define a genus may be different from, overlap with, be a subset of, be equivalent to, or be nearly identical to or identical to any other member of the species list. Furthermore, unless explicitly stated, as in describing Markush groups, a species list defining or exemplifying a genus is open, and there may be other species that define or exemplify the genus as well as or better than any other species listed.

[0021] For readability purposes, chemical functional groups are presented in their adjectival form; for each adjective, it is assumed that the word "group" is used. For example, the adjective "alkyl" without a noun following it should be read as "alkyl group."

[0022] As used herein, the term "cosmetically acceptable carrier" refers to a physiologically acceptable medium that is compatible with keratinous substances. Suitable carriers are well known in the art and are selected based on the end-use application. Preferably, the carrier of the present invention is suitable for application to the skin (e.g., in the form of a cream, emulsion, lotion, mask, serum, aqueous dispersion, foundation, cream gel or gel, etc.). Such carriers are well known to those of ordinary skill in the art and may include one or more compatible liquid or solid filler diluents, excipients, adjuvants, additives or vehicles suitable for application to the skin.

[0023] Personal care compositions include hair care, skin care, sunscreen, and nail care compositions. In some embodiments, the personal care compositions are applied to the skin or scalp of a person. Examples of personal care compositions include body washes, shower gels, lotions, bar soaps, soft soaps, shampoos, conditioners, sunscreens, and cosmetics. Personal care compositions may be classified and regulated by national or international regulatory agencies as cosmetics or as drugs.

[0024] In other embodiments, body wash is a liquid product used to clean the body during showering. Body wash includes natural and / or synthetic detergents derived from petroleum or plant sources. Body wash has a lower pH than soap and is generally less drying to the skin than soap.

[0025] In further embodiments, shower gel is synonymous with shower gel. In an alternative embodiment, the viscosity of shower gel is higher than shower gel and has a firmer consistency. Shower gel may contain ingredients with a cooling sensation.

[0026] In certain embodiments, lotions are low viscosity topical preparations for application to the skin. The lotion is applied to the external skin with bare hands, a brush or a clean cloth. Lotions, such as hand lotions or body lotions, provide smoothness, moisturizing, softening and fragrance of the skin. Lotions can be used as drug delivery systems.

[0027] In some embodiments, the personal care composition comprises a surfactant. The surfactant can be any anionic, nonionic, amphoteric or zwitterionic surfactant or a combination thereof. The amount of the surfactant in the composition is at least 1 wt %. In other embodiments, the amount is 1 to 20 wt %, or at least 2, 3, 4, 5, 6, 7, 8, 9 or 10 wt %.

[0028] According to various embodiments, the surfactant accounts for 10%, 20%, 30%, 40% or 50% of the personal care composition. According to one embodiment, multiple surfactants are used to achieve the desired product quality. The primary surfactant provides good foaming ability and cleaning effect, while the auxiliary surfactant adds additional foaming quality, mildness to prevent irritation or excessive drying of the skin. In order to prevent the separation of ingredients, emulsifiers can be added. Additional ingredients include conditioning agents that moisturize the skin during and after the use of the product. Ingredients such as fragrances in the form of essential oils or fragrance oils and colorants in the form of water-soluble dyes can also be used.

[0029] A variety of anionic surfactants can be employed in personal care compositions, including, for example, long chain alkyl (C6-C 22 ) materials, such as long-chain alkyl sulfates, long-chain alkyl sulfonates, long-chain alkyl phosphates, long-chain alkyl ether sulfates, long-chain alkyl alpha-olefin sulfonates, long-chain alkyl taurates, long-chain alkyl isethionates (SCI), long-chain alkyl glyceryl ether sulfonates (AGES), sulfosuccinates, etc. These anionic surfactants can be alkoxylated, such as ethoxylated, but alkoxylation is not necessary. As salt forms containing sodium, potassium, alkyl and ammonium or alkanolammonium, these surfactants are generally highly water-soluble and can provide high foaming cleaning ability. Other equivalent anionic surfactants can be used. In one embodiment, the anionic surfactant includes sodium laureth sulfate, sodium alkanoyl polyether sulfate and combinations thereof. Any desired amount of anionic surfactants can be included. In one embodiment, the anionic surfactant is present in the composition in an amount of 0 to about 15% by weight. In one embodiment, the anionic surfactant is present in an amount of about 6 to about 8% by weight.

[0030] Amphoteric surfactants can also be included in the composition. These surfactants are characterized by high surfactant activity, foam formation and gentle combination usually. Amphoteric surfactants include but are not limited to derivatives of aliphatic secondary amines and tertiary amines, wherein the aliphatic atomic group can be straight or branched, and wherein one of the aliphatic substituents contains about 8 to about 18 carbon atoms, and one contains anionic water solubilizing groups, such as carboxyl, sulfonate, sulfate, phosphate or phosphonate. The example of such compound comprises 3-dodecylamino sodium propionate, 3-dodecylamino propane sodium sulfonate, N-alkyl taurine and N-high alkyl aspartic acid. Other equivalent amphoteric surfactants can also be used. Examples of amphoteric surfactants include, but are not limited to, a series of betaines, including, for example, higher alkyl betaines such as cocodimethyl carboxymethyl betaine, lauryl dimethyl carboxymethyl betaine, lauryl dimethyl α-carboxyethyl betaine, hexadecyl dimethyl carboxymethyl betaine, lauryl bis-(2-hydroxyethyl) carboxymethyl betaine, stearyl bis-(2-hydroxypropyl) carboxymethyl betaine, oleyl dimethyl γ-carboxypropyl betaine and lauryl bis-(2-hydroxypropyl) α-carboxyethyl betaine, sulfobetaines such as cocodimethyl sulfopropyl betaine, stearyl dimethyl sulfopropyl betaine, amidobetaines, amidosulfobetaines, etc. Betaines with long chain alkyl groups (particularly coconut oil groups) may be particularly useful, such as those containing amide groups, such as cocamidopropyl and cocamidoethyl betaine. Amphoteric surfactants may be included in any desired amount. In one embodiment, the amphoteric surfactant is present in the composition in an amount of 0 to about 15 wt %. In one embodiment, the amphoteric surfactant is present in the composition in an amount of about 4 to about 6 wt %.

[0031] Examples of nonionic surfactants include: polysorbate 20; 22 Long chain alkyl glucosides of alkyl groups; coconut fatty acid monoethanolamides such as cocamide MEA; coconut fatty acid diethanolamide, fatty alcohol ethoxylates (alkyl polyethylene glycols); alkylphenol polyethylene glycols; alkylthiol polyethylene glycols; fatty amine ethoxylates (alkylamino polyethylene glycols); fatty acid ethoxylates (acyl polyethylene glycols): polypropylene glycol ethoxylates (e.g., PLURONIC™ block copolymers commercially available from BASF); fatty acid alkanolamides (fatty acid amide polyethylene glycols); N-alkyl-, N-alkoxy polyhydroxy fatty acid amides; sucrose esters; sorbitol esters; polyethylene glycol ethers; and combinations thereof. The nonionic surfactant may be included in any desired amount. In one embodiment, the nonionic surfactant is present in the composition in an amount of 0 to about 30% by weight, optionally about 10 to about 25% by weight. In one embodiment, the nonionic surfactant is present in the composition in an amount of about 0.5 to about 1.5% by weight.

[0032] Cationic surfactants can also be included in the composition. Examples of cationic surfactants include any quaternary ammonium salt or polyquaternium salt compounds. Cationic surfactants can be included at any desired level. In one embodiment, the cationic surfactant is present in the composition in an amount of 0 to about 2 % by weight. In one embodiment, the cationic surfactant is present in the composition in an amount of about 0.1 to about 0.3 % by weight.

[0033] In some embodiments, the personal care compositions of the present invention are substantially free of anionic surfactants. In other embodiments, the personal care compositions of the present invention are free of anionic surfactants. In some embodiments, the personal care compositions of the present invention are substantially free of cationic surfactants. In other embodiments, the personal care compositions of the present invention are free of cationic surfactants.

[0034] As used herein, the term "substantially free" is intended to mean negligible amounts, such as less than about 3% by weight of the composition, preferably less than 1% by weight of the composition.

[0035] Additional ingredients may be present in the personal care compositions. These include water and ingredients for thickening, preserving, emulsifying, perfuming and adding color.

[0036] Natural or synthetic skin compatible oils can be included in the composition. Skin compatible oils include a series of liquid hydrocarbons, for example, straight and branched oils such as liquid paraffin, squalene, squalane, mineral oil, low viscosity synthetic hydrocarbons such as polyalphaolefins obtained from ExxonMobil under the trade name PURESYN PAO and polybutenes obtained under the trade name PANALANE or INDOPOL. Light (low viscosity) high branched hydrocarbon oils may also be suitable in some cases. Other available skin compatible oils can be based on silicone, for example, linear and cyclic polydimethylsiloxane, organofunctional group silicone (alkyl and alkyl aryl) and amino silicone. The natural skin compatible oils of one or more plant origins can be included in the composition, for example coconut oil, sunflower oil, sweet almond oil, avocado oil, olive oil, castor oil, jojoba oil, sesame oil, safflower oil, almond oil, soybean oil, grape seed oil or hazelnut oil.

[0037] In other embodiments, the composition may include any of the following materials in any desired amount to achieve the desired effect in the composition (amounts that can be used in some embodiments are provided): one or more alkaline salts, such as sodium chloride, sodium sulfate, sodium carbonate, sodium bicarbonate, and / or their equivalents (0 to 5 wt %); foaming agents, such as decyl glucoside and / or its equivalents (0 to about 30 wt %, optionally about 10 to about 25 wt %); glycerides and derivatives, such as ethylene glycol distearate and / or its equivalents (0 to 3 wt %); chelating agents, such as tetrasodium EDTA and / or its equivalents (0 to 2 wt %); biocides, such as triclosan (2,4,4'-trichloro-2' -hydroxydiphenyl ether), DMDM ​​hydantoin and / or imidazolidinyl urea and / or their equivalents (0 to 2% by weight); organic acids, such as citric acid and / or lactic acid and / or their equivalents (0 to 2% by weight); viscosity modifiers (0 to 2% by weight); fragrances and / or flavors (0 to 5% by weight); preservatives, such as phenoxyethanol, parabens, pentylene glycol or sorbic acid (0 to 2% by weight); pearlescent agents, such as glycol distearates such as ethylene glycol distearate and fatty acid monoglycol esters (0 to 3% by weight); stabilizers, such as metal salts of fatty acids such as, for example, magnesium stearate, aluminum stearate and / or zinc stearate (0 to 2% by weight); dyes and pigments approved and suitable for cosmetic use.

[0038] The composition may include water. Water may be included in an amount of 0 to about 90 wt %. In one embodiment, water is present in an amount of about 50 wt % to about 90 wt %.

[0039] In some embodiments, the moisturizing shower gel composition also uses a blend of PEG-150 distearate and PPG-2 hydroxyethyl cocamide as a thickener to offset the reduction in viscosity associated with the concentration of the moisturizer used in some embodiments of the moisturizing shower gel composition. This blended thickener allows the composition to obtain a viscosity that exceeds the viscosity that can be obtained with conventional thickeners such as sodium chloride alone, and can obtain a suitable viscosity at a relatively low concentration. The relatively low concentration used to obtain the desired viscosity is also advantageous for the manufacturing process that can be used to manufacture the moisturizing shower gel composition, thereby reducing the need for larger equipment or transformation and the capital expenditure associated with manufacturing the moisturizing shower gel composition compared to if other thickeners are used. PEG-150 distearate and PPG-2 hydroxyethyl cocamide can be present in any amount to obtain the desired viscosity. In one embodiment, the amount of PEG-150 distearate in the composition is 0 to about 2 weight %. In one embodiment, the amount of PPG-2 hydroxyethyl cocamide in the composition is 0 to about 2 weight %. In one embodiment, the weight ratio of PEG-150 distearate to PPG-2 hydroxyethyl cocamide can be about 3:1 to about 1:3. In one embodiment, PEG-150 distearate and PPG-2 hydroxyethyl cocamide are each present at 0.0225 weight percent. PEG-150 distearate and PPG-2 hydroxyethyl cocamide are available as a mixture under the trade name PROMIDIUMTM LTS from Uniqema.

[0040] Microbeads can also be added to personal care compositions. Microbeads are tiny spheres that are added to various cosmetics for their exfoliating properties.

[0041] Personal care compositions may also contain menthol ingredients, which provide a cooling and stimulating sensation to the skin, and some men's shower gels are also designed for use on the hair and body. Shower gels contain a milder surfactant base than shampoos, and some also have mild conditioning agents in the formula. This means that shower gels can also double as an effective and perfectly acceptable shampoo alternative, even if they are not labeled as a hair and body wash. Washing your hair with a shower gel should have about the same effect as using a moisturizing shampoo.

[0042] In certain embodiments, the present invention provides a method of treating, preventing, or ameliorating symptoms associated with a disease, disorder, or condition of the skin, comprising applying to the skin of a subject in need thereof an effective amount of any one of the personal care compositions described herein.

[0043] In certain embodiments, the personal care composition has a pH of about 3.5 to about 10.0. In other embodiments, the personal care composition has a pH of about 3.5 to about 8.0. In some embodiments, the personal care composition has a pH of about 3.5 to about 7.5. In other embodiments, the personal care composition has a pH of about 3.5 to about 7.0. In further embodiments, the personal care composition has a pH of about 3.5 to about 6.5. Other embodiments provide personal care compositions having a pH of about 3.5 to about 6.0. Other embodiments provide personal care compositions having a pH of about 3.5 to about 5.5. Other embodiments provide personal care compositions having a pH of about 3.5 to about 5.0. In certain embodiments, the personal care composition has a pH of about 3.75 to about 4.5.

[0044] In certain embodiments, the personal care composition has a viscosity of from about 2,000 centipoise (cP) to about 20,000 cP, or from about 3,000 cP to about 16,000 cP, or from about 4,000 cP to about 12,000 cP, including all values ​​therebetween.

[0045] In certain embodiments, the personal care composition is substantially free of sulfate-containing surfactants. In certain embodiments, the personal care composition is free of sulfate-containing surfactants.

[0046] In certain embodiments, the personal care composition further comprises a cationic polymer. In certain embodiments, the cationic polymer provides conditioning benefits. In certain embodiments, the cationic polymer comprises a copolymer of acrylamide and diallyldimethylammonium chloride.

[0047] In certain embodiments, the personal care composition further comprises a prebiotic polysaccharide. In certain embodiments, the prebiotic polysaccharide comprises fructan. In other embodiments, the prebiotic polysaccharide comprises inulin. In certain embodiments, the prebiotic polysaccharide is present in an amount of about 0.1 wt % to about 5 wt %, optionally about 0.5 wt % to about 3 wt %, further optionally about 2 wt %.

[0048] Additional ingredients may be present in the personal care compositions. These include water and ingredients for thickening, preserving, emulsifying, perfuming and adding color.

[0049] In some embodiments, the composition may further include certain additives, including, for example, proteins (e.g., hydrolyzed vegetable protein, hydrolyzed wheat protein, hydrolyzed milk protein, hydrolyzed silk protein, and hydrolyzed collagen), vitamins (e.g., panthenol, biotin, vitamin E acetate, vitamin A and D palmitate), moisturizers / humectants (e.g., glycerin, propylene glycol, sodium pyroglutamate (also known as PCA), amino acid-based surfactants, and HLA), emollients (e.g., esters, isopropyl myristate, decyl oleate, C benzoate, and glyceryl stearate). 12-15 alkyl esters), oils (e.g., coconut, jojoba, aloe, safflower, almond, argan, sunflower, avocado, flaxseed), herbs (e.g., chamomile, aloe, rosemary), as well as preservatives, dyes, pH adjusters and chelating agents.

[0050] In certain embodiments, emulsifiers may be added to prevent separation of the ingredients. In certain embodiments, additional ingredients may include conditioning agents to moisturize the skin during and after use of the product. In other embodiments, ingredients such as fragrances in the form of essential or fragrance oils and colorants in the form of water-soluble dyes may also be used.

[0051] In certain embodiments, the composition may include vitamins, including but not limited to tocopherol, retinol and ascorbic acid. In one embodiment, the composition may include vitamin derivatives, such as ascorbyl monopalmitate, tocopheryl acetate and vitamin E palmitate. In one embodiment, the composition may include vitamins and vitamin derivatives.

[0052] The personal care composition may further include one or more fragrances. The fragrance may be present in an amount of about 0.01% by weight to about 2.0% by weight, based on the total weight of the personal care composition, including all percentages and subranges therebetween. In some embodiments, the fragrance may be present in an amount of about 0.4% by weight to about 1.7% by weight, based on the total weight of the soap composition, including all percentages and subranges therebetween.

[0053] Non-limiting examples of aromas and / or fragrances include odor compounds selected from the group consisting of: 7-acetyl-1,2,3,4,5,6,7,8-octahydro-1,1,6,7-tetramethylnaphthalene, α-ionone, β-ionone, γ-ionone α-isomethylionone, methyl cedryl ketone, methyl dihydrojasmonate, methyl 1,6,10-trimethyl-2,5,9-cyclododecatrien-1-yl ketone, 7-acetyl-1,1,3,4,4,6-hexamethyltetrahydronaphthalene, 4 -Acetyl-6-tert-butyl-1,1-dimethylindane, hydroxyphenyl butanone, benzophenone, methyl β-naphthyl ketone, 6-acetyl-1,1,2,3,3,5-hexamethylindane, 5-acetyl-3-isopropyl-1,1,2,6-tetramethylindane, 1-dodecanal, 4-(4-hydroxy-4-methylpentyl)-3-cyclohexene-1-carboxaldehyde, 7-hydroxy-3,7-dimethyloctanal, 10-undecene-1-carboxaldehyde, isohexenylcyclohexylcarboxaldehyde, formyltricyclodecane, hydroxy condensation products of hydroxycitronellal and methyl anthranilate, condensation products of hydroxycitronellal and indole, condensation products of phenylacetaldehyde and indole, 2-methyl-3-(p-tert-butylphenyl)propanal, ethyl vanillin, piperonal, hexylcinnamaldehyde, amylcinnamaldehyde, 2-methyl-2-(isopropylphenyl)propanal, coumarin, γ-decanolide, cyclopentadecalactone, 16-hydroxy-9-hexadecenoic acid lactone, 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopentadienol Pentyl-γ-2-benzopyran, β-naphthol methyl ether, ambergris, dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1b]furan, cedrol, 5-(2,2,3-trimethylcyclopent-3-enyl)-3-methylpentan-2-ol, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol, caryophyllene alcohol, tricyclodecenyl propionate, tricyclodecenyl acetate, benzyl salicylate, cedrol acetate, and tert-butylcyclohexyl acetate.

[0054] Other fragrances may include odoriferous compounds selected from essential oils, resinoids and resins from a number of sources, such as Peru balsam, frankincense resin, styrax, labdanum resin, nutmeg, cinnamon oil, benzoin resin, coriander and striking lavender.

[0055] Other suitable fragrances include odor compounds selected from the group consisting of phenylethyl alcohol, terpineol, linalool, linalyl acetate, geraniol, nerol, 2-(1,1-dimethylethyl)cyclohexanol acetate, benzyl acetate and eugenol. The fragrances or essences can be used as single substances or in the form of mixtures with one another.

[0056] The personal care composition can further include one or more colorants. The colorant can be a pigment, a dye or a mixture thereof. The non-limiting examples of pigments include titanium dioxide, zinc oxide, kaolin, mica, etc. The non-limiting examples of dyes include food dyes and mixtures thereof suitable for food, drug and cosmetic applications. Some pigments (colorants) are called FD&C dyes.

[0057] The colorant may be present in an amount of about 0.0001% to about 0.4% by weight, based on the total weight of the soap composition, including all percentages and subranges therebetween. In some embodiments, the colorant may be present in an amount of about 0.0001% to about 4% by weight, based on the total weight of the personal care composition, including all percentages and subranges therebetween.

[0058] Personal care compositions may include a silicon-containing component. The silicon-containing component may include one or more silicone oils, such as polydimethylsiloxane. Polydimethylsiloxane is a mixture of fully methylated linear siloxane polymers terminated with trimethylsiloxy units. Polydimethiconol is a dimethyl silicone polymer terminated with hydroxyl groups. These silicone oils are relatively non-volatile liquids.

[0059] The silicone oil may be a copolymer, such as dimethicone-copolyol. Dimethicone-copolyol may include one or more copolymers of dimethylpolysiloxane with polyoxyethylene and / or polyoxypropylene side chains. The copolymer may alternatively include the phosphorylated silicone polymer of the above patent, which may be referred to as dimethicone copolyol phosphate. In terms of chemical structure, the phosphate group forms the end of the polyoxyalkylene side chain, and the terminal hydroxyl group has been converted into an ester bond with the phosphate group.

[0060] In some embodiments, the present invention provides a personal care composition comprising: a gum system comprising a plurality of natural gums; a surfactant system comprising a plurality of alkyl polyglucoside surfactants; and a cosmetically acceptable carrier.

[0061] In some embodiments, the natural gum is selected from the group consisting of xanthan gum, carrageenan, agar, alginates (e.g., alginic acid or sodium alginate), gum arabic, gum ghatti, tragacanth, karaya gum, guar gum, locust bean gum, acacia gum, konjac gum, pectin, sclerotium gum, scleroglucan, beta-glucan, dammar gum, glucomannan, psyllium husk, tara gum, and gellan gum. In further embodiments, the natural gum is selected from the group consisting of xanthan gum, carrageenan, guar gum, karaya gum, alginates, and gum arabic. In other embodiments, the plurality of natural gums comprises two natural gums. In further embodiments, the plurality of natural gums comprises xanthan gum and carrageenan.

[0062] In some embodiments, the adhesive system accounts for about 0.1% to about 3% by weight of the total weight of the composition. In other embodiments, the adhesive system accounts for about 0.5% to about 2% by weight of the total weight of the composition. Additional embodiments provide personal care compositions wherein the adhesive system accounts for about 0.75% to about 1.5% by weight of the total weight of the composition. Other embodiments provide personal care compositions wherein the adhesive system accounts for about 1% by weight of the total weight of the composition.

[0063] In other embodiments, the plurality of alkyl polyglucoside surfactants include a first alkyl polyglucoside surfactant and a second alkyl polyglucoside surfactant. In some embodiments, the first alkyl polyglucoside surfactant and the second alkyl polyglucoside surfactant are present in a weight ratio of about 6: 1. Additional embodiments provide personal care compositions, wherein the first alkyl polyglucoside surfactant and the second alkyl polyglucoside surfactant are present in a weight ratio of about 4: 1 to about 1: 4. Other embodiments provide personal care compositions, wherein the first alkyl polyglucoside surfactant and the second alkyl polyglucoside surfactant are present in a weight ratio of about 3.5: 1 to about 1: 3.6. Other embodiments provide personal care compositions, wherein the first alkyl polyglucoside surfactant and the second alkyl polyglucoside surfactant are present in a weight ratio of about 3: 1 to about 1: 3. In some embodiments, the first alkyl polyglucoside surfactant and the second alkyl polyglucoside surfactant are present in a weight ratio of about 2.5: 1 to 1: 2.5. Other embodiments provide personal care compositions wherein the first alkyl polyglucoside surfactant and the second alkyl polyglucoside surfactant are present in a weight ratio of about 2.5:1 to about 1:2.5. Additional embodiments provide personal care compositions wherein the first alkyl polyglucoside surfactant and the second alkyl polyglucoside surfactant are present in a weight ratio of about 2:1 to about 1:1.

[0064] In certain embodiments, the plurality of alkyl polyglucoside surfactants are selected from: decyl glucoside; capryl glucoside; capryl glucoside; lauryl glucoside; coco glucoside; and mixtures thereof (e.g., capryl / capryl glucoside). In various embodiments, the plurality of alkyl polyglucoside surfactants include: decyl glucoside and capryl / capryl glucoside.

[0065] Other embodiments of the present invention are personal care compositions further comprising a prebiotic agent. In further embodiments, the prebiotic agent comprises inulin.

[0066] In some embodiments, the compositions described herein further comprise an emollient. In some embodiments, the emollient comprises sunflower oil.

[0067] Additional embodiments provide compositions further comprising an antioxidant. In certain embodiments, the antioxidant is selected from the group consisting of: vitamin A, niacinamide; vitamin C; vitamin E; polyphenols; resveratrol; coenzyme Q10; flavonoids; and combinations of two or more thereof.

[0068] Additional embodiments provide personal care compositions including a prebiotic agent; a polysaccharide gum; and a cosmetically acceptable carrier.

[0069] Other embodiments provide a method for cleaning a keratinous surface of a subject in need thereof, comprising applying a personal care composition according to any preceding claim to the keratinous surface of the subject. Some embodiments provide methods further comprising the step of rinsing the keratinous surface to remove at least a portion of the personal care composition. Additional embodiments provide methods further comprising the step of rinsing the keratinous surface until the personal care composition is substantially removed therefrom. In some embodiments, the keratinous surface is selected from the group consisting of: hair; skin; nails; and combinations of two or more thereof.

[0070] In some embodiments, the present invention provides a personal care composition comprising: a humectant (e.g., about 5-10%, or about 6% glycerin); a natural gum system (e.g., about 0.5 to 2%, or 1% of a mixture of xanthan gum (e.g., 0.7%) and carrageenan (e.g., 0.3%)); a polyglucoside surfactant system (e.g., about 15-25%, or about 22% of a mixture of capryl / capryl glucoside (16.95%) and decyl glucoside (4.84%)); a skin compatible oil (e.g., about 3 to 4% sunflower oil); a prebiotic agent (e.g., about 2%); an antioxidant (e.g., about 0.01 to about 0.5% vitamin E); an organic acid (e.g., a mixture of lactic acid (about 0.1 to about 1%) and citric acid (about 0.5% to about 2%)); and water.

[0071] In other embodiments, the present invention provides a personal care composition comprising: a humectant (e.g., about 5-10%, or about 6% glycerin); a natural gum system (e.g., about 0.5 to 2%, or 1% of a mixture of xanthan gum (e.g., 0.7%) and carrageenan (e.g., 0.3%)); a polyglucoside surfactant system (e.g., about 10-15%, or about 14% of a mixture of capryl / capryl glucoside (-10%) and decyl glucoside (3%)); a skin compatible oil (e.g., about 3 to 4% sunflower oil); a prebiotic agent (e.g., about 2%); an antioxidant (e.g., about 0.01 to about 0.5% vitamin E); an organic acid (e.g., a mixture of lactic acid (about 0.1 to about 1%) and citric acid (about 0.5% to about 2%)); and water.

[0072] The present invention also relates to a method for cleaning keratinous material, comprising applying the personal care composition according to any one of the embodiments to the skin of a subject in need thereof. Spreading of the personal care composition can be done by hand, or can be done by a tool such as a glove, a pad, or a piece of cloth. In certain embodiments of the method, the keratinous surface is selected from: skin, hair; nails; and combinations of two or more thereof. In certain embodiments of the method, the method further comprises rinsing the skin to which the personal care composition has been applied.

[0073] In some embodiments, the method of applying the personal care composition may leave a film. The thickness of the film depends on the rest of the formulation, but for lotions, the thickness will be comparable to that of other lotions, body washes, or deodorants. For those embodiments where the personal care composition is a lotion, the thickness is about 50 μm.

[0074] In some embodiments, the present invention also relates to a method for treating, preventing or ameliorating symptoms associated with a disease, disorder or condition of keratinous material, comprising applying a personal care composition according to any one of the embodiments described herein to the keratinous material of a subject in need thereof. In some embodiments, the disease, disorder or condition of keratinous material is selected from: inflammation; irritation; dryness, etc.

[0075] In certain embodiments, the present invention also relates to a method of cleaning keratinous material, comprising applying a personal care composition according to any embodiment provided herein to a keratinous material of a subject in need thereof. In certain embodiments, the keratinous material is selected from the group consisting of: skin, hair, nails, and combinations of two or more thereof. In certain embodiments, the method further comprises rinsing the personal care composition from the keratinous material to which it is applied.

[0076] The following examples further describe and demonstrate illustrative embodiments within the scope of the present invention. The examples are given for illustration only and should not be construed as limiting the present invention, as there may be many variations without departing from its spirit and scope. Various modifications to the present invention other than those shown and described herein will be apparent to those skilled in the art and are intended to fall within the scope of the appended claims.

[0077] Examples

[0078] Example 1: Exemplary and comparative compositions

[0079] Unless otherwise indicated, all percentages and amounts expressed herein and elsewhere in this specification should be understood to refer to percentages by weight. The amounts given are based on the active weight of the material.

[0080] Table 1: Shower Gel (Example 1)

[0081] Element w / w% water 50-70 glycerin 5-10 Xanthan gum 0.1-2 Carrageenan 0.1-2 Caprylyl / caprylyl glucoside 0.1-20 Decyl Glucoside 0.1-20 Sunflower Oil 0.1-5 Vitamin E 0.01-1 Inulin 0-10 Aroma 0.1-2 lactic acid 0.05-1 Citric Acid 0.05-2

[0082] Table 2: Hand Sanitizer (Example II)

[0083] Element w / w% water 60-80 Glycerin (USP and EP) 5-10 Xanthan gum 0.1-2 Carrageenan 0.1-2 Caprylyl / caprylyl glucoside 0.1-20 Decyl Glucoside 0.1-10 Sunflower Oil 0.1-5 Vitamin E 0.10 Inulin 0-10 Aroma 0.1-2 lactic acid 0.1-2 Citric Acid 0.1-2

[0084] Table 3: Shower gel and hand soap (Examples III-IX)

[0085]

[0086]

[0087] Table 4: Comparative Example (Comparative Example I)

[0088] Element water Lauryl Glucoside Decyl Glucoside Sucrose laurate Coco-Glucoside Olein Citric Acid glycerin Sodium chloride Tocopherol Hydrogenated Palm Glycerides Citrate Lecithin Ascorbyl Palmitate Potassium Sorbate Aroma Phenoxyethanol Citral Eugenol Limonene Linalool

[0089] Table 5: Comparative Example (Comparative Example II): Conventional shower gel

[0090]

[0091]

[0092] Table 6: Comparative Example (Comparative Example III)

[0093] Element water Decyl Glucoside glycerin Coco-Glucoside Sunflower Oil Sodium Gluconate Aroma Xanthan gum Sodium Lactate Citric Acid lactic acid Carrageenan Vitamin E Soybean Oil

[0094] Table 7: Comparative Example (Comparative Example IV)

[0095]

[0096]

[0097] Table 8: Comparative Example (Comparative Example V)

[0098]

[0099] Tables 9, 10, and 11 (below) represent exemplary body wash and hand soap formulations containing only capryl / capryl glucoside, only decyl glucoside, and a combination of capryl / capryl glucoside and decyl glucoside in varying ratios (ranging from 3.5:1 to 1:3.6).

[0100] Table 9

[0101]

[0102] Table 10: Exemplary Body Wash

[0103]

[0104]

[0105] Table 11: Exemplary Hand Sanitizers

[0106]

[0107] The compositions described herein can be made by conventional techniques generally known to those skilled in the art. For example, the main water is added to a container equipped with a central turbine agitator, and the prebiotic (e.g., inulin) is premixed with 4-5% water; the gum is premixed with glycerin. The premix is ​​then added to the main batch and heated to about 60°C. After the mixture has cooled to about 40°C or less, caprylyl / caprylyl glucoside and decyl glucoside are added. Then, the oil and antioxidant are slowly added, followed by the aroma. Then, the organic acid is added and titrated to reach the desired pH of about 4.

[0108] Example 2

[0109] Foam testing or characterization can be performed using a variety of methods. For example, foam structure and characterization can be performed using a Dynamic Foam Analyzer Model DFA 100 available from Kruss USA of Matthews, North Carolina.

[0110] Foam distribution can also be measured using a mechanical cylinder vibration foam method, such as the Gaum Foam Method.

[0111] The foam test measurement is used to evaluate the foam distribution of the exemplary body wash and hand soap of the present invention and the comparative examples described herein. The measurement is performed using a mechanical graduated cylinder vibration foam method and a Gaum foam height machine purchased from Gaum, Inc. of Robbinsville, New Jersey. Flash foam, maximum foam and drain time are measured.

[0112] Procedure: Weigh 75g of the test body wash or hand soap in a beaker. Weigh 425g of deionized water in a 1000mL glass beaker and place a 1" magnetic stir bar in it. Place the beaker on a stir / hot plate and begin mixing until the body wash or hand soap is completely dispersed. Mix at a speed that produces very little foam. Heat the solution to 41-42°C. Once the solution reaches 41-42°C, the solution is ready. Make enough to use in 3 graduated cylinder tests. Keep the sample at a constant temperature of 41-42°C when not being used for testing. Heat the DI water to 45°C. Fill a 500mL graduated cylinder with 45°C DI water. Allow the DI water to sit in the graduated cylinder for a few minutes. Drain the DI water from the graduated cylinder before pouring the body wash solution and testing. When the body wash test solution temperature is reached, drain the 500mL glass graduated cylinder. When the body wash test solution reaches 41-42°C, pour 100g of the body wash test solution into the 500mL graduated cylinder. Tilt the graduated cylinder at an angle and pour it into the graduated cylinder at a slow rate so that almost no foam is generated when pouring. Put in a Teflon rod and seal it with a rubber stopper. Connect a 500mL graduated cylinder to a rotator assembly (Gaum foam machine) to keep the graduated cylinder in a vertical plane while rotating. Rotate the graduated cylinder at a constant speed (30RPM) for the following cycle:

[0113] a. Flash foam measurement

[0114] 8 cycles: After 8 cycles the foam volume is read. For each product the average and standard deviation of 3 samples are taken.

[0115] b. Maximum foam and drainage time measurement

[0116] 12 cycles: Start timing immediately after the cycle is completed. Read the maximum foam volume after 12 cycles of maximum foam and stop timing once the liquid portion in the measuring cylinder reaches the discharge time of 100 mL.

[0117] For each product, the average and standard deviation of 3 samples were taken. Drain time is defined as the time measured from the completion of 12 cycles to the discharge of 100 mL of liquid. Drain time is a measure of the wetness and stability of the foam.

[0118] Table 12: Flash Lather - 8 Cycles for Exemplary Body Wash

[0119]

[0120] Table 13: Maximum Foam - 12 Cycles for Exemplary Body Wash

[0121]

[0122] Table 14: Drain Time - 12 Cycles for Exemplary Body Wash

[0123]

[0124] Table 15: Foam Test for Exemplary Body Washes

[0125]

[0126] Table 16: Drain Time for Exemplary Body Wash (12 Cycles)

[0127] product Draining time (hours: minutes: seconds) (12 cycles) Standard Deviation Comparative Example III 0:06:27 0:01:05 Example III 0:09:41 0:01:37 Example X 0:15:55 0:01:37 Example XI 0:12:26 0:04:54 Example XV 0:12:30 0:00:24 Example XII 0:11:08 0:02:54 Example XIII 0:10:44 0:01:50 Example XIV 0:08:07 0:02:22

[0128] Table 17: Foam Test for Exemplary Hand Sanitizers

[0129]

[0130] Table 18: Drain Time for Exemplary Hand Sanitizer (12 Cycles)

[0131]

[0132]

[0133] Tables 12 to 18 describe the foam evaluation test results of exemplary body wash and hand soap formulations including various alkyl polyglucoside surfactant systems (e.g., octanoyl / decanoyl glucoside alone, decyl glucoside alone, and combinations of octanoyl / decanoyl glucoside and decyl glucoside in different ratios (ratios of 3.5:1 to 1:3.6). Higher flash foam (mL) and maximum foam height (mL) indicate greater foam volume. The longer the drain time, the more stable the foam. Both the flash foam test and the drain time test provide an overall foam distribution. Varying the combined ratio of octanoyl / decanoyl glucoside and decyl glucoside from 3.5:1 to 1:3.6 provides the best ratio for foam distribution.

[0134] Example 3: Probiotics Testing

[0135] The prebiotic effects of the pure ingredients inulin and carrageenan and the combination of inulin and carrageenan were tested in vitro. Growth inhibition assays were performed to test whether the pure prebiotic ingredients inhibited or promoted the growth of skin bacteria. Pure colonies of Escherichia coli, Corynebacterium fasciatum, Staphylococcus aureus and Staphylococcus epidermidis were grown overnight in tryptic soy broth (TSB) medium. The turbidity of the bacterial culture solution was adjusted to 0.1 OD (optical density) at 610 nm using a UV-VIS spectrometer Lambda 45 purchased from Perkin-Elmer. The pure ingredients were diluted into a certain concentration of tryptic soy broth (TSB) medium. 2 ml of bacterial culture was incubated with 2 ml of 2% or 5% inulin or 0.3% carrageenan at 37°C for 24 hours. Bacteria incubated only with the medium were considered as controls. After incubation, the turbidity of each tube was read at 610 nm using a UV-VIS spectrometer. Each treatment was repeated. The mean OD number of the prebiotic was subtracted from the control number. If the value is negative, the prebiotic inhibits bacterial growth, and if the value is positive, the prebiotic promotes bacterial growth. The results show that 0.3% carrageenan, 2% and 5% inulin, and the combination of carrageenan and inulin selectively inhibited the growth of undesirable bacteria (Escherichia coli, Corynebacterium fasciatum, and Staphylococcus aureus) in vitro, but promoted the growth of desirable bacteria (Staphylococcus epidermidis) (see, e.g. Figure 1 ).

[0136] The prebiotic effect of the prototype shower gel formula incorporating prebiotics was also tested in vitro. A conventional competitive shower gel was included as a control. 2% inulin AGA was incorporated into the shower gel formula. The shower gel was diluted to a 1% solution in TSB medium. Pure colonies of Corynebacterium striata and Staphylococcus epidermidis were grown overnight in TSB medium. The turbidity of the bacterial culture solution was adjusted to 0.1OD (optical density) at 610nm using a UV-VIS spectrometer. Then, 2ml of the bacterial culture solution was incubated with 2ml1% shower gel solution at 37°C for 3 hours. After incubation for 3 hours, the mixed solution was diluted 10 times in TSB. 100ul of bacterial solution was spread on a tryptic soy agar plate and incubated overnight at 37°C. The bacterial colonies on the plate were counted the next day. In Minitab software, the statistical significance of the number of bacterial colonies between treatments was analyzed by ANOVA at a 95% confidence level. The results showed that the prototype shower gel containing 2% inulin exhibited a prebiotic effect compared to conventional shower gel. It significantly increased the growth of desirable bacteria (Staphylococcus epidermidis) and reduced undesirable bacteria (odor-causing bacteria) compared to conventional shower gel (Comparative Example II). Figure 2 ).

[0137] Example 4: Barrier function test

[0138] External company Genoskin uses The model tested the ex vivo skin benefits of a prototype body wash containing prebiotics. Prior to model production, skin biopsies collected from human donors during surgery were tape stripped using 50 consecutive strips (MonaDerm, DS100) to remove the stratum corneum. The model was maintained under cell culture conditions (37°C, 5% CO2, and maximum humidity) using 1 mL of standard The culture medium was cultured for 3 or 5 days. 10 μL of shower gel was topically applied to the skin surface so that the compound covered the entire surface in a uniform manner. The shower gel sample was kept in contact for 60 seconds and then rinsed with phosphate buffered saline (PBS). This procedure was repeated 3 times, and the model was finally rinsed 3 times. The treatment was renewed every day. On the 3rd and 5th days, the model was divided into 2 batches, the skin tissue was processed for fluorescent yellow analysis, and the rest was processed for histological analysis. 50 μL of 1mM fluorescent yellow was topically applied to the surface of the skin model. Then, the model was incubated for 4 hours under cell culture conditions (at 37°C, in a CO2 incubator with a water-saturated atmosphere). Then, a cotton swab was used to remove the fluorescent yellow, and the skin biopsy was fixed in 10% buffered formalin (e.g., HT501128 purchased from Sigma Aldrich) for 48 hours and processed for paraffin embedding. Fluorescent yellow dye penetration indicates skin barrier, and the less dye penetration, the stronger the skin barrier. Hematoxylin and eosin staining was performed on 5 μm thick paraffin-embedded skin cross sections. For each sample, 3 transmitted light photographs were obtained using a Leica DMi1 microscope at 40X magnification. Histological staining demonstrated the integrity of the skin structure.

[0139] In vitro studies have shown that conventional shower gels have a strong negative effect on skin integrity and vitality. On day 5, the skin structure of the conventional shower gel treatment group was damaged, while the prototype shower gel containing inulin maintained the normal structure of the skin and the stratum corneum was regenerated after treatment (see e.g. Figure 3 ).

[0140] Lewis Yellow dye penetration assays showed that skin tissue treated with the prototype shower gel containing prebiotics had less dye penetration into the epidermis, suggesting that the tissue treated with the prototype prebiotic shower gel had a stronger skin barrier than tissue treated with a conventional shower gel (Comparative Example II) and even untreated tissue (see e.g. Figure 4 ).

[0141] Example 5: Analysis of Alkyl Polyglucoside

[0142] The analysis of the carbon chain distribution of different alkyl polyglucosides (APGs) in the raw material and the finished product was used to determine the optimal ratio for the foaming curve. The carbon chain distribution of the alkyl polyglucosides (APG) raw material was determined by an Agilent 1200 series HPLC equipped with an Agilent 1290 InfinityII evaporative light scattering detector (ELSD) and an Agilent 1260 Infinity II HPLC equipped with a single quadrupole mass spectrometer. The carbon chain homologues were separated using a reverse phase mobile phase gradient of 0.1% formic acid in water and 0.1% formic acid in methanol using a Zorbax SB-C18 column (Agilent part number 863953-902) and an Agilent Eclipse Plus phenyl-hexyl column (Agilent part number 959941-912). The ELSD parameters were 35°C evaporator temperature / 35°C nebulizer temperature / 1.6L / min nitrogen flow. The concentration of the raw material sample in a diluent containing 10% water and 90% methanol was 2.0mg / mL. Carbon chain homologues are identified by relative retention times and single ion monitoring on a single quadrupole mass spectrometer. The expected elution order is characterized by the carbon number in the alkyl homologues: increased chain length leads to longer retention times (Kühn, Characterization of Mixtures of Alkyl Polyglycosides (Plantacare) by Liquid Chromatography-Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometry, 2004, pp. 2347-2353).

[0143] The results were calculated by normalized area percentage and they showed that the decyloctyl glucoside raw material (Plantaren 810 UP) contained C8 and C10 homologues, while the decyloctyllauryl glucoside raw material (Plantaren 818 UP, Plantaren 2000N UP) contained C8, C10, C12 and C14 homologues.

Claims

1. Use of inulin in the preparation of a personal care composition for promoting the growth of desired bacteria including Staphylococcus epidermidis, wherein the personal care composition comprises: Glue systems including a variety of natural rubbers; prebiotics including inulin; a surfactant system comprising a plurality of alkyl polyglucoside surfactants; and A cosmetically acceptable carrier, wherein inulin is present in an amount of 2 wt % to 5 wt % of the total weight of the composition; wherein the plurality of alkyl polyglucoside surfactants are present in an amount of 15 wt % to 25 wt % of the total weight of the composition; wherein the plurality of alkyl polyglucoside surfactants comprises a first alkyl polyglucoside surfactant and a second alkyl polyglucoside surfactant, and The first alkyl polyglucoside surfactant and the second alkyl polyglucoside surfactant are present in a weight ratio of 4:1 to 2:

1.

2. The use according to claim 1, wherein the gum system further comprises a natural gum selected from the group consisting of: xanthan gum; agar; alginate; alginic acid; gum arabic; gum ghatti; gum tragacanth; gum karaya; guar gum; locust bean gum; β-glucan; gum dammar; glucomannan; tara gum; and gellan gum.

3. The use according to claim 2, wherein the alginate is sodium alginate.

4. The use according to claim 1 or claim 2, wherein the gum system further comprises a natural gum selected from the group consisting of: xanthan gum; guar gum; karaya gum; alginate; and gum arabic.

5. Use according to any preceding claim, wherein the plurality of natural gums comprises two natural gums.

6. Use according to any preceding claim, wherein the plurality of natural gums comprises: Xanthan gum and carrageenan.

7. Use according to any preceding claim, wherein the gum system comprises from 0.1 wt% to 3 wt% of the total weight of the composition.

8. Use according to any preceding claim, wherein the gum system comprises from 0.5% to 2% by weight of the total weight of the composition.

9. Use according to any preceding claim, wherein the gum system comprises from 0.75% to 1.5% by weight of the total weight of the composition.

10. The use according to claim 1, wherein the plurality of alkyl polyglucoside surfactants comprises a mixture of about 22% of capryl / capryl glucoside 16.95% and decyl glucoside 4.84% based on the total weight of the composition.

11. The use according to claim 1, wherein the first alkyl polyglucoside surfactant and the second alkyl polyglucoside surfactant are present in a weight ratio of about 3.5:

1.

12. The use according to any preceding claim, wherein the plurality of alkyl polyglucoside surfactants is selected from: decyl glucoside; caprylyl glucoside; capryl glucoside; lauryl glucoside; coco glucoside; and mixtures thereof.

13. The use according to claim 12, wherein the plurality of alkyl polyglucoside surfactants are selected from capryl / capryl glucoside.

14. The use according to any preceding claim, wherein the plurality of alkyl polyglucoside surfactants comprises: Decyl Glucoside and Capryl / Capryl Glucoside.

15. Use according to any preceding claim, further comprising an emollient.

16. The use according to claim 15, wherein the emollient comprises sunflower oil.

17. Use according to any preceding claim, further comprising an antioxidant.

18. The use according to claim 17, wherein the antioxidant is selected from the group consisting of: vitamin A, niacinamide; vitamin C; vitamin E; polyphenols; resveratrol; coenzyme Q10; flavonoids; and combinations of two or more thereof.

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