Tissue defect occlusion device and surgical suture

Abstract

The application relates to a tissue defect plugging device and a surgical suture, a distal end is pushed out from inside a conveying sheath, the distal end simultaneously pierces a first atrial septum and a second atrial septum at an oval foramen; the distal end can be reversely pierced into the second atrial septum and the first atrial septum under the elastic force of a memory material body; because the distal end reversely pierces the atrial septum, barbs on the distal end side wall simultaneously pierce the second atrial septum and the first atrial septum, and the distal end is prevented from moving in a direction away from the proximal end, that is, when a pushing assembly continuously pushes out a suture body, the distal end can continuously move forward and pierce the second atrial septum and the first atrial septum; finally, the proximal end of the suture is knotted, and the proximal end is separated from the pushing assembly, and the like. At this time, the knot point of the proximal end of the suture and the barbs of the distal end of the suture fix the suture as a whole on the first atrial septum and the second atrial septum, and make the tissues of the first atrial septum and the second atrial septum tightly adhere to each other.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical suture instruments, in particular to a tissue defect plugging device and surgical suture thread. BACKGROUND

[0002] Oval foramen is a physiological channel in the embryonic period of heart atrial septum. The fetus has no pulmonary circulation, and the oxygen-containing blood from the umbilical cord flows into the left atrium through the oval foramen from the right atrium of the fetus. After birth, with the establishment of pulmonary circulation, the left atrial pressure increases, the secondary septum and the primary septum approach and adhere to each other and gradually form a permanent atrial septum. However, part of the population does not fuse, which forms patent foramen ovale (PFO for short). In most cases, the pressure of the left atrium of the human heart is greater than that of the right atrium, and the PFO channel is in a closed state. In some specific cases, the PFO channel can be pushed open to form a passage between the left and right atria. Embolus from the venous system can enter the systemic circulation system through the PFO channel, and if embolism occurs in the cerebral arterial system, it will show as cerebral stroke or transient ischemic attack (TIA for short).

[0003] The common transcatheter interventional plugging method for patent foramen ovale is to implant a PFO occluder. The PFO occluder usually comprises two disc surfaces (defined as left disc surface and right disc surface) and a thin waist connecting the two disc surfaces. The occluder is usually made of super-elastic metal material, such as nickel-titanium alloy. It can be compressed into an elongated strip shape, transported through a delivery catheter along the blood vessel path from the outside of the body to the atrial septum position. After being delivered to the designated position, the PFO occluder is released from the delivery catheter and recovers its original two-disc-one-waist shape. The two disc surfaces are respectively attached to the left and right atrial sides, and the waist is placed in the PFO channel. Thus, the secondary septum and the primary septum approach and fuse with each other. After the device is implanted, the endothelium will gradually grow, and eventually wrap the entire PFO occluder to form complete plugging.

[0004] In the traditional technology, the PFO occluder is used to plug the holes at both ends of the oval foramen to close the oval foramen and block the blood flow. However, due to the pathological and physiological structure of PFO, the tunnel shape between the primary septum and the secondary septum, and the complex PFO accompanied by atrial septal aneurysm or multiple atrial septal defects with various shapes and sizes, if the shape of the PFO occluder is not truly suitable for the pathological and physiological structure of the human body, it will bring risks to the operation, including PFO occluder shedding, incomplete blood flow closure, poor plugging effect, and complex operation, etc. SUMMARY

[0005] The present application provides a tissue defect plugging device and surgical suture thread to solve one or more technical problems in the prior art.

[0006] The technical scheme is as follows: a surgical suture line comprises: a suture line body, the suture line body is a memory material body, the suture line body is a bent line body in a natural stretched state; the suture line body is provided with opposite distal and proximal ends; the distal end is provided with a sharp shape capable of penetrating the target tissue, and a barb is arranged on the side wall of the distal end; the umbrella tip of the barb is closer to the head of the distal end than the umbrella mouth of the barb; the proximal end is used for being connected with a pushing assembly.

[0007] In one of the embodiments, the bent line body comprises at least three straight line segments connected in sequence, or comprises at least one arc-shaped line segment, or comprises a combination of at least one straight line segment and at least one arc-shaped line segment.

[0008] In one of the embodiments, the suture line body further comprises a middle segment connecting the distal end and the proximal end; in the natural stretched state, the middle segment comprises a straight line segment and / or an arc-shaped line segment.

[0009] In one of the embodiments, the extension direction of the proximal end is defined as a first direction, the extension direction of the distal end is defined as a second direction, the included angle formed by the first direction and the second direction is a, and a is 120° to 180°.

[0010] In one of the embodiments, the proximal end and the distal end are each provided as a straight line segment; in the natural stretched state, the distal end is parallel to the proximal end.

[0011] In one of the embodiments, the middle segment is provided as a straight line segment, the suture line body further comprises a first arc-shaped line segment connecting one end of the middle segment and the distal end, and a second arc-shaped line segment connecting the other end of the middle segment and the proximal end.

[0012] In one of the embodiments, in the natural stretched state, the length of the distal end is 1mm to 10mm, the length of the middle segment is 5mm to 10mm, and the length of the proximal end is 5mm to 20mm.

[0013] In one of the embodiments, the barb is at least two, and all the barbs are arranged in sequence along the extension direction of the distal end.

[0014] In one of the embodiments, the suture line body is a memory alloy or a memory metal; the barb and the suture line body are an integrated structure.

[0015] In one of the embodiments, the proximal end is provided with a positioning part in the natural stretched state.

[0016] In one of the embodiments, the positioning part is a spiral structure or a folding structure or a positioning ring.

[0017] In one of the embodiments, the proximal end tail is provided with a threaded connector, which is rotationally connected with the pushing assembly.

[0018] A tissue defect plugging device, comprising the surgical suture.

[0019] In one of the embodiments, the tissue defect plugging device further comprises a delivery sheath and a pushing assembly arranged in the delivery sheath; the suture body is connected with the pushing assembly and arranged inside the delivery sheath.

[0020] The above-mentioned tissue defect plugging device and surgical suture, in use, are delivered to the vicinity of the foramen ovale through a blood vessel by means of a delivery sheath, and the distal end is pushed out from inside the delivery sheath by a pushing assembly, so as to simultaneously puncture the first and second atrial septums at the foramen ovale; the suture body is continuously pushed out by the pushing assembly, so as to be exposed outside the delivery sheath, and it will naturally relax; at this time, since the suture body is in a bent shape in a natural stretched state, the distal end of the suture is turned in the opposite direction, and under the elastic force of the memory material body, the distal end is reversely punctured through the second and first atrial septums; since the distal end reversely punctures the atrial septums, the barbs on the distal end side wall simultaneously puncture the second and first atrial septums, and can prevent the distal end from moving away from the proximal end, that is, when the pushing assembly continuously pushes out the suture body, the distal end can continuously move forward (i.e. move towards the proximal end), and puncture the second and first atrial septums; finally, the proximal end of the suture is knotted, and separated from the pushing assembly. At this time, the knot of the proximal end of the suture and the barbs of the distal end of the suture fix the whole suture on the first and second atrial septums, and make the tissues of the first and second atrial septums tightly adhere to each other. BRIEF DESCRIPTION OF DRAWINGS

[0021] The accompanying drawings, which form a part of the present application, are intended to provide further understanding of the present application, and are used to interpret the specific embodiments of the present application and their descriptions, and do not constitute improper limitations to the present application.

[0022] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the accompanying drawings needed to be used in the embodiment description will be briefly introduced. Obviously, the accompanying drawings in the following description are only some embodiments of the present application, and other accompanying drawings can be obtained by those skilled in the art without any creative effort.

[0023] Figure 1 The structure schematic diagram of the tissue defect plugging device of an embodiment of the present application in working state;

[0024] Figure 2 Fig. 3 is a schematic diagram showing the structure of the tissue defect plugging device in operation according to another embodiment of the present application;

[0025] Figure 3 Fig. 4 is a schematic diagram showing the structure of the tissue defect plugging device in operation according to another embodiment of the present application;

[0026] Figure 4 Fig. 5 is a schematic diagram showing the structure of the tissue defect plugging device in operation according to another embodiment of the present application;

[0027] Figure 5 Fig. 6 is a schematic diagram showing the structure of the tissue defect plugging device in operation according to another embodiment of the present application;

[0028] Figure 6 Fig. 7 is a schematic diagram showing the structure of the tissue defect plugging device in operation according to another embodiment of the present application;

[0029] Figure 7 Fig. 8 is a schematic diagram showing the structure of the tissue defect plugging device in operation according to another embodiment of the present application;

[0030] Figure 8 Fig. 9 is a schematic diagram showing the structure of the tissue defect plugging device in operation according to another embodiment of the present application.

[0031] 10, suture body; 11, distal end; 111, barb; 1111, umbrella tip; 1112, umbrella opening; 12, proximal end; 121, positioning portion; 13, middle section; 14, first arc-shaped line section; 15, second arc-shaped line section; 20, pushing assembly; 30, first atrial septum; 40, second atrial septum; 50, delivery sheath; 60, oval foramen. DETAILED DESCRIPTION

[0032] In order to make the above objectives, features and advantages of the present application more apparent, specific embodiments of the present application will be described in detail below with reference to the accompanying drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present application. It will be apparent, however, to one skilled in the art that the present application can be practiced without some or all of these specific details. In other instances, well known process steps have not been described in detail in order not to unnecessarily obscure the present application.

[0033] Here, it should be noted that the proximal end refers to the end of the suture body closer to the operator, and the distal end refers to the end of the suture body farther from the operator, i.e., the end that contacts and punctures the atrial septum earlier than the proximal end.

[0034] Referring to Figure 1 , Figure 1The structure of the tissue defect plugging device is shown in the working state. The tissue defect plugging device includes a surgical suture. It is suitable for oval foramen 60 closure, blood vessel suture, atrial septal defect suture, ventricular septal defect suture, etc. In one embodiment, the surgical suture includes a suture body 10. The suture body 10 is a memory material body, and the suture body 10 is in a bent line body (as shown) in a natural stretched state. The suture body 10 is provided with opposite distal end 11 and proximal end 12. The distal end 11 is provided with a sharp shape capable of piercing the target tissue, and the side wall of the distal end 11 is provided with a barb 111. The umbrella tip 1111 of the barb 111 is closer to the head of the distal end 11 than the umbrella mouth 1112 of the barb 111. The proximal end 12 is used to connect with the push assembly 20. Figure 1

[0035] It should be noted that the head of the distal end 11 refers to the end point of the distal end 11 farthest away from the proximal end 12 along the extension path direction of the suture body 10; on the contrary, the tail of the distal end 11 refers to the end point of the distal end 11 closest to the proximal end 12 along the extension path direction of the suture body 10.

[0036] It should be noted that since the umbrella tip 1111 of the barb 111 is closer to the head of the distal end 11 than the umbrella mouth 1112 of the barb 111, when the distal end 11 pierces the atrial septum, the barb 111 will also pierce the atrial septum smoothly at the same time, and after the barb 111 pierces the atrial septum, the barb 111 can avoid moving back and away from the atrial septum, and can only continue to move forward under the pushing force of the push assembly 20.

[0037] ​The surgical suture line is delivered to the vicinity of the foramen ovale 60 through the blood vessel by the delivery sheath 50 in use, and the distal end 11 is pushed out of the delivery sheath 50 by the pushing assembly 20, so that the distal end 11 simultaneously pierces the first interatrial septum 30 and the second interatrial septum 40 at the foramen ovale 60; the suture line body 10 is continuously pushed out by the pushing assembly 20, so that the suture line body 10 is exposed outside the delivery sheath 50 and is naturally relaxed, at this time, since the suture line body 10 is in a bent shape in a natural stretched state, the orientation of the distal end 11 of the suture line is reversed, and the distal end 11 reversely pierces the second interatrial septum 40 and the first interatrial septum 30 under the elastic force of the memory material body; since the distal end 11 reversely pierces the interatrial septum, the barb 111 on the side wall of the distal end 11 synchronously pierces the second interatrial septum 40 and the first interatrial septum 30, and prevents the distal end 11 from moving away from the proximal end 12, that is, when the pushing assembly 20 continuously pushes out the suture line body 10, the distal end 11 continuously moves forward (that is, moves towards the proximal end 12) and pierces the second interatrial septum 40 and the first interatrial septum 30; finally, the proximal end 12 of the suture line is knotted and separated from the pushing assembly 20. At this time, the knot of the proximal end 12 of the suture line and the barb 111 of the distal end 11 of the suture line fix the suture line on the first interatrial septum 30 and the second interatrial septum 40, and make the tissues of the first interatrial septum 30 and the second interatrial septum 40 tightly adhere to each other.

[0038] It should be noted that the "barb 111" can be "a part of the distal end 11", that is, the "barb 111" is integrally formed with the "other part of the distal end 11"; or can be a separate component separable from the "other part of the distal end 11", that is, the "barb 111" can be independently manufactured and combined with the "other part of the distal end 11" into an integral whole. As shown in Figure 1 , in an embodiment, the "barb 111" is integrally formed with the "distal end 11".

[0039] Please refer to Figures 1 to 5 , Figures 1 to 5 schematic surgical suture lines of different shapes, in an embodiment, the bent line body includes at least three straight line segments connected in sequence (as shown in Figure 1 ), or includes at least one arc-shaped line segment (as shown in Figure 2 ), or includes a combination of at least one straight line segment and at least one arc-shaped line segment (as shown in Figure 3 ). Thus, please refer to Figure 1When the bending line body is composed of at least three straight line segments connected in sequence, i.e. the distal end 11 is set as the first straight line segment, so that the distal end 11 is first output from the delivery sheath 50 and pierces the first atrial septum 30 and the second atrial septum 40, since the distal end 11 is set as a straight line segment, the straight line segment acts perpendicularly on the first atrial septum 30 and the second atrial septum 40, the force is concentrated, and the first atrial septum 30 and the second atrial septum 40 can be more easily pierced. After the straight line segment pierces the atrial septum and enters the left atrium from the right atrium, the remaining straight line segments enter the left atrium in sequence, and in the process of restoring the shape of the bending line body under the elastic force of the memory material body, the distal end 11 can be turned by 180° and can again pierce the second atrial septum 40 and the first atrial septum 30 in the opposite direction until it returns to the right atrium.

[0040] Please refer to Figure 4 As an optional solution, the bending line body includes three straight line segments connected in sequence, and an arc-shaped line segment arranged in series between adjacent two straight line segments. When the arc-shaped line segment is arranged in series between adjacent two straight line segments, it plays a transition role and can facilitate the smooth puncture of the first atrial septum 30 and the second atrial septum 40 by the adjacent two straight line segments.

[0041] As an optional solution, when the bending line body adopts an arc-shaped line segment, the arc-shaped line segment is specifically, for example, a circular arc-shaped line segment or an elliptical arc-shaped line segment, or when the bending line body adopts a combination of an arc-shaped line segment and a straight line segment, the entire puncture process described above can also be achieved.

[0042] Please refer to Figures 1 to 5 In an embodiment, the suture body 10 further includes a middle segment 13 connecting the distal end 11 and the proximal end 12. In the natural stretched state, the suture body 10 includes a straight line segment and / or an arc-shaped line segment, the extension direction of the proximal end 12 is defined as a first direction (as shown by the arrow S1 in Figure 1 , and the extension direction of the distal end 11 is defined as a second direction (as shown by the arrow S2 in Figure 1 , and the included angle between the first direction and the second direction is a (not shown in the figure), a is 120° to 180°. In this way, the push assembly 20 continues to push out the suture body 10, so that the suture body 10 is exposed outside the delivery sheath 50 and naturally relaxes. At this time, since the suture body 10 is a bending line body in the natural stretched state, and the included angle a is 120° to 180°, the orientation of the suture distal end 11 is turned, and the distal end 11 can pierce the second atrial septum 40 and the first atrial septum 30 in the opposite direction under the elastic force of the memory material body.

[0043] Please refer to Figure 1 , Figures 3 to 5In one embodiment, the proximal end 12 and the distal end 11 are each a straight line segment. In the natural stretched state, the distal end 11 is parallel to the proximal end 12. Thus, the included angle a is 180 degrees, so that the distal end 11 of the suture body 10 is turned by 180 degrees, and under the elastic force of the memory material body, the distal end 11 can reversely pierce the second atrial septum 40 and the first atrial septum 30.

[0044] Please refer to Figure 4 In one embodiment, the middle segment 13 is a straight line segment, and the suture body 10 further comprises a first arc-shaped segment 14 connecting one end of the middle segment 13 with the distal end 11, and a second arc-shaped segment 15 connecting the other end of the middle segment 13 with the proximal end 12. Thus, after the distal end 11 pierces the atrial septum, the middle segment 13 can also smoothly pierce the atrial septum due to the connection of the first arc-shaped segment 14 and the middle segment 13, and the first arc-shaped segment 14 is a circular arc chamfer which causes less damage to the tissue. Similarly, after the middle segment 13 pierces the atrial septum, the proximal end 12 can also smoothly pierce the atrial septum due to the connection of the second arc-shaped segment 15 and the proximal end 12, and the second arc-shaped segment 15 is a circular arc chamfer which causes less damage to the tissue.

[0045] In one embodiment, in the natural stretched state, the length of the distal end 11 is 1mm to 10mm, the length of the middle segment 13 is 5mm to 10mm, and the length of the proximal end 12 is 5mm to 20mm.

[0046] It should be noted that the length of the distal end 11 refers to the length of the distal end 11 when it is completely stretched and straightened, the length of the middle segment 13 refers to the length of the middle segment 13 when it is completely stretched and straightened, and the length of the proximal end 12 refers to the length of the proximal end 12 when it is completely stretched and straightened.

[0047] In one embodiment, the suture body 10 is a memory alloy or a memory metal. Thus, the use of memory alloy or memory metal causes less damage to human tissue, and the memory alloy or memory metal is durable, has a long service life, and has a low cost. The memory alloy includes but is not limited to titanium-nickel alloy, aluminum alloy, titanium alloy, and nickel alloy, which can be selected according to actual needs.

[0048] Please refer to Figure 1 In one embodiment, the barb 111 is at least two, and all the barbs 111 are sequentially arranged along the extension direction of the distal end 11. Thus, the at least two barbs 111 can fix the distal end 11 on the atrial septum, so as to avoid the distal end 11 from falling off the atrial septum, and the connection structure is stable.

[0049] Of course, as an optional solution, the barb 111 can also be one, and one barb 111 can also fix the distal end 11 on the atrial septum, so as to avoid the distal end 11 from falling off the atrial septum.

[0050] In one embodiment, the barb 111 is integrated with the suture body 10. In this way, the barb 111 and the suture body 10 are integrally formed during the production process, which is more efficient.

[0051] Referring to Figures 6 to 8 In one embodiment, the proximal end 12 is provided with a positioning portion 121 in the natural stretched state. In this way, when the proximal end 12 is fully released, the positioning portion 121 can abut against the first atrial septum 30 to prevent the proximal end 12 from moving forward, which serves as a knot point of the proximal end 12.

[0052] Referring to Figures 6 to 8 In one embodiment, the positioning portion 121 is a spiral structure (as shown in Figure 6 ), a folded structure (as shown in Figure 7 ), or a positioning ring (as shown in Figure 8 ). In this way, when the positioning portion 121 is fully released, it can expand into a spiral structure, a folded structure, or a positioning ring, which can stably abut against the first atrial septum 30 to prevent the proximal end 12 from moving forward, which serves as a knot point of the proximal end 12.

[0053] Referring to Figure 1 In one embodiment, the tail of the proximal end 12 is provided with a threaded connector (not shown in the figure), which is rotationally connected to the pushing assembly 20. In this way, the pushing assembly 20 is correspondingly provided with a threaded hole corresponding to the threaded connector, and the pushing assembly 20 drives the threaded connector to uncoil by rotating, so that the suture body 10 is pushed out from the inside of the delivery sheath 50.

[0054] Referring to Figure 1 In one embodiment, the tissue defect occlusion device further comprises a delivery sheath 50 and a pushing assembly 20 arranged in the delivery sheath 50. The suture body 10 is connected to the pushing assembly 20 and arranged inside the delivery sheath 50. In this way, during use, the delivery sheath 50 is used to deliver the suture body 10 to the vicinity of the foramen ovale 60 through the blood vessels, and the suture body 10 is gradually pushed out from the inside of the delivery sheath 50 by the pushing assembly 20, finally realizing the mutual suturing and close contact of the first atrial septum 30 and the second atrial septum 40.

[0055] In summary, the tissue defect occlusion device and the surgical suture in the above embodiments have at least the following advantages:

[0056] 1. The structure is simple, and one or more surgical sutures can be used to directly adhere the two layers of atrial septums of the foramen ovale 60 together, which can obtain better sealing effect and complete flow blocking effect compared with the use of traditional occluders, and the operation is relatively simple.

[0057] 2. The barb 111 provided on the distal end 11 can more conveniently fix the distal end 11 of the suture body 10; the positioning part 121 provided on the proximal end 12 can conveniently position the proximal end 12, and it is not necessary to knot with auxiliary tools, and the operation difficulty is greatly reduced.

[0058] 3. The metal material implanted in the body is less, and the adverse effects on the human body can be reduced.

[0059] The technical features of the above embodiments can be combined arbitrarily, and in order to make the description simple, all possible combinations of the technical features in the above embodiments are not described, however, as long as the combination of the technical features does not exist contradictory, it should be considered as the scope of the description.

[0060] The above-described embodiments only express several embodiments of the present application, and the description is more specific and detailed, but it cannot be understood as limiting the scope of the patent. It should be pointed out that for ordinary skilled in the art, without departing from the concept of the present application, a number of modifications and improvements can be made, which are within the scope of the present application. Therefore, the protection scope of the patent of the present application should be subject to the appended claims.

[0061] In the description of the present application, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application.

[0062] In addition, the terms "first", "second" are only for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the technical features indicated. Therefore, the features limited by "first", "second" can explicitly or implicitly include at least one of the features. In the description of the present application, the meaning of "a plurality of" is at least two, for example, two, three, etc., unless otherwise specifically limited.

[0063] In the present application, unless specifically defined otherwise, the terms "mounting", "connected", "connecting", "fixed", and "fixing" should be construed as broad terms, for example, can be fixed connection, can also be detachable connection, or integrated; can be mechanical connection, can also be electrical connection; can be directly connected, can also be indirectly connected through an intermediate medium, can be the internal communication of two elements or the interaction relationship of two elements, unless otherwise explicitly defined. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0064] In the present application, unless specifically defined otherwise, the first feature is "on" or "under" the second feature can be that the first and second features are in direct contact, or the first and second features are indirectly in contact through an intermediate medium. Moreover, the first feature "above", "over" and "on" the second feature can be that the first feature is directly above or obliquely above the second feature, or only indicates that the horizontal height of the first feature is higher than that of the second feature. The first feature "below", "under" and "under" the second feature can be that the first feature is directly below or obliquely below the second feature, or only indicates that the horizontal height of the first feature is less than that of the second feature.

[0065] It should be noted that when an element is referred to as "fixed to" or "disposed on" another element, it can be directly on the other element or there can be a middle element. When an element is considered to be "connected" to another element, it can be directly connected to the other element or there can be a middle element. The terms "vertical", "horizontal", "up", "down", "left", "right" and similar expressions used herein are for illustrative purposes only and are not the only implementation.

Claims

1. A tissue defect occlusion device, comprising: The tissue defect plugging device comprises a surgical suture, a delivery sheath, and a pushing assembly arranged in the delivery sheath. The surgical suture body is connected with the pushing assembly and arranged inside the delivery sheath, and is a memory material body, which is a bent wire body in a natural stretched state.

2. The tissue defect occlusion device of claim 1, wherein, The distal end is provided with barbs on the side wall.

3. The tissue defect occlusion device of claim 2, wherein, The barb umbrella tip is closer to the head of the distal end than the barb umbrella mouth.

4. The tissue defect occlusion device according to any one of claims 1 to 3, wherein, The proximal end is connected with the pushing assembly.

5. The tissue defect occlusion device of claim 4, wherein, The pushing assembly continues to push out the surgical suture body, so that the surgical suture body is exposed outside the delivery sheath and naturally relaxes, and the distal end of the surgical suture body changes direction.

6. The tissue defect occlusion device of claim 3, wherein, The bent wire body comprises at least three straight line segments connected in sequence, or at least one arc-shaped line segment, or a combination of at least one straight line segment and at least one arc-shaped line segment.

7. The tissue defect occlusion device of claim 3, wherein, The surgical suture body further comprises a middle segment connecting the distal end and the proximal end.

8. The tissue defect occlusion device of claim 1, wherein, The middle segment comprises a straight line segment and / or an arc-shaped line segment in the natural stretched state of the surgical suture body.

9. The tissue defect occlusion device of claim 1, wherein, The extension direction of the proximal end is defined as a first direction, and the extension direction of the distal end is defined as a second direction.

10. The tissue defect occlusion device of claim 1, wherein, The first direction and the second direction form an included angle a, and a is 120° to 180°.

11. The tissue defect occlusion device of claim 10, wherein, The proximal end and the distal end are each provided as a straight line segment.

12. The tissue defect occlusion device of claim 1, wherein, The distal end is parallel to the proximal end in the natural stretched state of the surgical suture body. The middle segment is provided as a straight line segment, and the surgical suture body further comprises a first arc-shaped line segment connecting one end of the middle segment and the distal end, and a second arc-shaped line segment connecting the other end of the middle segment and the proximal end. The length of the distal end is 1mm to 10mm, the length of the middle segment is 5mm to 10mm, and the length of the proximal end is 5mm to 20mm in the natural stretched state of the surgical suture body. The barbs are at least two, and all the barbs are arranged in sequence along the extension direction of the distal end. The surgical suture body is a memory alloy or a memory metal. The proximal end is provided with a positioning part in the natural stretched state. The positioning part is a spiral structure or a folding structure or a positioning ring. The proximal end tail is provided with a threaded connector, and the threaded connector is rotationally connected with the pushing assembly.

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