Biological detection device, biological detection chip and refrigerator

Abstract

The present application relates to a biological detection device, a biological detection chip and a refrigerator, the biological detection chip has at least one sampling chamber for containing an extraction solution. The biological detection device comprises a support having a chip mounting portion for mounting the biological detection chip, the chip mounting portion is provided with at least one sample adding structure corresponding to the sampling chamber one by one, each sample adding structure is arranged to push a solid sample resting outside the corresponding sampling chamber into the sampling chamber when the biological detection chip is mounted to the chip mounting portion, so that the solid sample is soaked in the extraction solution in the sampling chamber. Therefore, the sample adding operation can be automatically completed during the installation of the biological detection chip, the user only needs to rest the solid sample outside the sampling chamber and directly install the biological detection chip, without other operations, and without setting other auxiliary sample adding driving mechanisms on the biological detection device, which simplifies the structure of the biological detection device, reduces the cost, and improves the user experience.

Description

Technical Field

[0001] The present invention relates to refrigeration and freezing technology, and in particular to a biological detection device, a biological detection chip and a refrigerator. Background Art

[0002] As people's living standards improve, they often need to test some of the food they eat for pesticide residues, viruses, nutrients, or other aspects in their daily lives to qualitatively or quantitatively determine the condition of the food. For example, due to the overuse of pesticides, the fruits, vegetables, and agricultural and sideline products we buy daily may contain excessive levels of pesticide residues. If these excessive levels of pesticide residues are not detected in a timely manner, they can cause great harm to the human body after ingestion. For another example, breastfeeding, which is currently advocated, is the best way to feed babies only when breast milk has normal nutritional value. However, if a nursing mother is ill, taking medication, undergoing surgery, or in other circumstances, the nutrient content of her milk may decrease or even contain viruses, thereby affecting the growth, development, and health of the baby.

[0003] Among numerous detection methods, bioassay chips are relatively fast, compact, and suitable for home use. However, existing bioassay chips require either manual sample loading, which is inconvenient, or require an auxiliary liquid storage device, which uses an auxiliary liquid drive mechanism to mix the auxiliary liquid with the sample to produce a sample solution, and then uses the sample liquid drive mechanism to drive the sample solution to complete the sample loading operation. This is a very cumbersome process and a very complex structure. Summary of the Invention

[0004] One object of the first aspect of the present invention is to overcome at least one drawback of the prior art and to provide a biological detection device capable of automatically adding samples during the installation of a biological detection chip.

[0005] A further purpose of the first aspect of the present invention is to further simplify user operations and improve user experience.

[0006] Another further object of the first aspect of the present invention is to simplify the structure of the biological detection device and facilitate the long-term storage of the biological detection chip used in conjunction with it.

[0007] The second aspect of the present invention aims to provide a biological detection chip suitable for installation on the biological detection device involved in any of the above solutions.

[0008] A third aspect of the present invention is to provide a refrigerator having the biological detection device according to any of the above-mentioned solutions.

[0009] According to a first aspect of the present application, the present application provides a biological detection device for mounting a biological detection chip having at least one sampling chamber for containing an extraction solution, wherein the biological detection device comprises:

[0010] a bracket having a chip mounting portion for mounting the biological detection chip, the chip mounting portion being provided with at least one sample loading structure corresponding to the sampling chamber, each sample loading structure being arranged to push a solid sample resting outside the corresponding sampling chamber into the sampling chamber when the biological detection chip is mounted to the chip mounting portion, so as to immerse the solid sample in the extraction solution in the sampling chamber.

[0011] Optionally, a side wall of each sampling chamber for contacting the solid sample is arranged to be at least partially a penetrable wall; and

[0012] each sample loading structure is arranged to push the solid sample outside the corresponding sampling chamber and to penetrate the penetrable wall of the sampling chamber when the biological detection chip is mounted to the chip mounting portion, so that the solid sample enters the sampling chamber.

[0013] Optionally, the sample loading structure is a sample loading boss protruding towards the biological detection chip, the sample loading boss being hollow inside and being provided with a plurality of partitioning ribs arranged in intervals.

[0014] Optionally, the chip mounting portion is further provided with a connecting column corresponding to the sample loading structure and being arranged adjacent to the sample loading structure, the connecting column being provided with a connecting channel inside, for penetrating the penetrable wall of the corresponding sampling chamber by the connecting column after the biological detection chip is mounted to the chip mounting portion, so that the connecting channel in the connecting column is in communication with the corresponding sampling chamber;

[0015] The biological detection device further comprises a driving mechanism arranged on the bracket and being in communication with the connecting channel of each connecting column, so that the driving mechanism is in communication with each sampling chamber of the biological detection chip after the biological detection chip is mounted to the chip mounting portion, thereby controllably driving the fluid flow in each sampling chamber.

[0016] Optionally, the biological detection chip further comprises at least one reaction chamber corresponding to the sampling chamber and being independent of each other, for containing a reaction reagent, at least a part of the peripheral wall of the reaction chamber being a penetrable wall;

[0017] The chip mounting portion is also provided with a first piercing structure having a first through-channel formed therein, which is used to pierce the penetrable walls of the corresponding reaction chamber and the sampling chamber after the biological detection chip is mounted on the chip mounting portion, and allow fluid communication between the corresponding reaction chamber and the sampling chamber through the first through-channel.

[0018] Optionally, the biological detection chip further includes at least one detection chamber corresponding to and independent of the sampling chamber, for containing detection reagents, and each detection chamber has a liquid injection port;

[0019] The chip mounting portion is further provided with a second piercing structure having a second through-channel formed therein, which is used to pierce the penetrable wall of the corresponding reaction chamber after the biological detection chip is mounted on the chip mounting portion, and allow the reaction chamber to communicate with the liquid injection port of the corresponding detection chamber through the second through-channel.

[0020] According to the second aspect of the present invention, the present invention also provides a biological detection chip suitable for installation in the biological detection device described in any of the above-mentioned schemes, the biological detection chip has at least one sampling chamber for containing the extract, and the outer side of each sampling chamber is provided with a sampling port for placing a solid sample, and the sampling port corresponds one-to-one with the position of the sample loading structure of the biological detection device, so as to allow each sample loading structure to push the solid sample placed on the corresponding sampling port into the corresponding sampling chamber when the biological detection chip is installed to the biological detection device.

[0021] Optionally, the sampling port is separated from the corresponding sampling chamber by a side wall of the sampling chamber, and the side wall is configured to be at least partially permeable, so as to allow the sample loading structure to penetrate the permeable wall when pushing the solid sample when the biological detection chip is installed on the biological detection device, thereby allowing the solid sample to enter the sampling chamber.

[0022] Optionally, there are multiple sampling chambers, and the multiple sampling chambers are isolated from each other.

[0023] According to a third aspect of the present invention, the present invention provides a refrigerator comprising the biological detection device described in any one of the above solutions.

[0024] The biological detection device of the present invention includes a bracket, a chip mounting portion is provided on the bracket, and a sample loading structure corresponding to the sampling chamber of the biological detection chip is provided on the chip mounting portion. The sample loading structure is configured to push a solid sample placed outside the sampling chamber into the sampling chamber when the biological detection chip is installed on the chip mounting portion, so that the solid sample is immersed in the extract in the sampling chamber, and the substance to be detected on the solid sample dissolves in the extract to produce a sample liquid. In this way, the sample loading operation can be automatically completed during the installation process of the biological detection chip. The user only needs to place the solid sample outside the sampling chamber and directly install the biological detection chip. No other operations are required, and there is no need to set other auxiliary sample loading drive mechanisms on the biological detection device. This simplifies the structure of the biological detection device, reduces its cost, improves the user experience, and makes it more suitable for home use.

[0025] Furthermore, the sample loading structure is designed to penetrate the penetrable wall of the sampling chamber when pushing the solid sample. Therefore, the sampling chamber of the biological detection chip can be made closed to facilitate pre-placement of the extraction liquid therein, eliminating the need for users to manually add the extraction liquid into the sampling chamber, further improving the user experience.

[0026] Furthermore, the chip mounting portion is also provided with a first piercing structure and a second piercing structure, and the first piercing structure and the second piercing structure are respectively provided with a first through channel and a second through channel. When the biological detection chip is mounted on the chip mounting portion, the first piercing structure is used to pierce the penetrable walls of the sampling chamber and the reaction chamber and form a fluid connection between the two, and the second piercing structure is used to pierce the penetrable wall of the reaction chamber and form a fluid connection between the reaction chamber and the detection chamber. Thus, complex connecting pipes are eliminated, the structure is simplified, and the sampling chamber, reaction chamber and detection chamber of the biological detection chip can be set to be spaced apart, which is beneficial to the long-term storage of the biological detection chip and allows liquid reagents to be pre-stored in its sampling chamber, reaction chamber or detection chamber.

[0027] Based on the following detailed description of specific embodiments of the present invention in conjunction with the accompanying drawings, those skilled in the art will become more aware of the above and other objects, advantages and features of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Hereinafter, some specific embodiments of the present invention will be described in detail in an exemplary and non-limiting manner with reference to the accompanying drawings. The same reference numerals in the accompanying drawings indicate the same or similar components or parts. It should be understood by those skilled in the art that these drawings are not necessarily drawn to scale. In the accompanying drawings:

[0029] Figure 1 is a schematic structural diagram of a biological detection device according to one embodiment of the present invention;

[0030] Figure 2 and Figure 3 They are schematic exploded views of the structure of a biological detection device in different directions according to an embodiment of the present invention;

[0031] Figure 4 yes Figure 2 A schematic enlarged view of the middle portion B;

[0032] Figure 5 is a schematic cross-sectional view of a biological detection device according to one embodiment of the present invention;

[0033] Figure 6 is a schematic front perspective view of a biological detection device according to one embodiment of the present invention;

[0034] Figure 7 and Figure 8 Schematic cross-sectional views of a biological detection chip according to an embodiment of the present invention taken along different cross-sectional planes;

[0035] Figure 9 is a schematic cross-sectional view of a biological detection chip installed in a biological detection device according to one embodiment of the present invention;

[0036] Figure 10 yes Figure 9 Schematic enlarged view of the middle part A;

[0037] Figure 11 is a schematic flow chart of a control method of a biological detection device according to one embodiment of the present invention;

[0038] Figure 12 is a schematic structural diagram of a refrigerator according to one embodiment of the present invention;

[0039] Figure 13 1 is a schematic structural exploded view of a door body according to one embodiment of the present invention. DETAILED DESCRIPTION

[0040] The present invention first provides a biological detection device for mounting a biological detection chip. The biological detection chip is used to perform qualitative or quantitative detection of preset detection parameters of a sample. The preset detection parameters may be, for example, a pesticide residue parameter indicating whether the pesticide residue exceeds the standard and / or the specific value of the pesticide residue, a nutritional parameter indicating whether a nutrient element meets the standard and / or the specific content of the nutrient element, a specific substance parameter indicating whether a specific harmful substance (such as a specific virus) exceeds the standard and / or the specific content, and the like. The biological detection chip has at least one sampling chamber for holding an extract. The extract is used for immersing the sample, dissolving the substance to be detected on the sample into the extract to form a sample solution for easy detection.

[0041] Figure 1is a schematic structural diagram of a biological detection device according to an embodiment of the present invention, Figure 2 and Figure 3 They are schematic structural exploded views of different aspects of a biological detection device according to an embodiment of the present invention, Figure 4 yes Figure 2 Schematic enlargement of part B. Figures 1 to 4 The biological detection device 1 of the present invention includes a bracket 10, which has a chip mounting portion 11 for mounting a biological detection chip 2. The chip mounting portion 11 is provided with at least one sample loading structure 70 corresponding to a sampling chamber. Each sample loading structure 70 is configured to push a solid sample placed on the outside of the corresponding sampling chamber into the sampling chamber when the biological detection chip 2 is mounted on the chip mounting portion 11, so that the solid sample is immersed in the extract in the sampling chamber. The substance to be detected on the solid sample dissolves in the extract to produce a sample liquid. In this way, the sample loading operation can be automatically completed during the installation of the biological detection chip. The user only needs to place the solid sample outside the sampling chamber and directly install the biological detection chip. No other operations are required, and there is no need to set up other auxiliary sample loading drive mechanisms on the biological detection device. This simplifies the structure of the biological detection device 1, reduces its cost, improves the user experience, and makes it more suitable for home use.

[0042] In some embodiments, the sidewalls of each sampling chamber 21 that are in contact with the solid sample are configured to be at least partially permeable. Each sample loading structure 70 is configured to push the solid sample outside the corresponding sampling chamber 21 and penetrate the permeable wall of the sampling chamber 21 when the biological detection chip 2 is mounted on the chip mounting portion 11, so that the solid sample enters the sampling chamber 21. Therefore, the structural design of the sample loading structure 70 can allow the sampling chamber 21 of the biological detection chip 2 to be made closed, so that the extraction liquid can be pre-placed therein, eliminating the need for the user to manually add the extraction liquid to the sampling chamber 21, further improving the user experience.

[0043] In some embodiments, the sample loading structure 70 is a sample loading boss protruding toward the biological detection chip 2. The interior of the sample loading boss is hollow, which reduces the contact area between the sample loading structure 70 and the penetrable wall of the sampling chamber 21 and increases the force per unit area of ​​the penetrable wall of the sampling chamber 21, thereby ensuring that the sample loading structure 70 can smoothly penetrate the penetrable wall of the sampling chamber 21 and push the solid sample into the sampling chamber 21, thereby successfully completing the sample loading operation.

[0044] Furthermore, a plurality of spaced-apart partition ribs 71 are provided inside the sample loading boss to increase the structural strength of the sample loading boss and prevent it from being deformed significantly when pushing the solid sample and the penetrable wall of the sampling chamber 21, thereby affecting its penetration or affecting its next use.

[0045] Figure 5 is a schematic cross-sectional view of a biological detection device according to an embodiment of the present application, Figure 6 is a schematic front perspective view of a biological detection device according to an embodiment of the present application. In some embodiments, the chip mounting portion 11 is further provided with a connecting post 17 corresponding to and adjacent to each sample adding structure 70, and the connecting post 17 is internally provided with a connecting channel 171, which is used to penetrate the penetrable wall 213 of the corresponding sample chamber 21 by the connecting post 17 after the biological detection chip 2 is mounted on the chip mounting portion 11, so that the connecting channel 171 in the connecting post 17 is in communication with the corresponding sample chamber 21.

[0046] Further, the biological detection device 1 further comprises a driving mechanism 30, which is arranged on the support 10 and in communication with the connecting channel 171 of each connecting post 17, so that the driving mechanism 30 is in communication with each sample chamber 21 of the biological detection chip 2 after the biological detection chip 2 is mounted on the chip mounting portion 11, thereby controllably driving the fluid flow in each sample chamber 21.

[0047] That is, the present application can realize the fluid communication between the connecting channel 171 and the sample chamber 21 during the mounting of the biological detection chip 2 on the chip mounting portion 11 by arranging the connecting post 17 on the chip mounting portion 11 and arranging the connecting channel 171 in the connecting post 17, thereby facilitating the accurate control of the fluid flow in the sample chamber 21 by the driving mechanism 30.

[0048] Further, the support 10 is internally formed with an internal channel 12, one end of which is in communication with the driving mechanism 30, and the other end is in communication with the connecting channel 171 of each connecting post 17, so that the driving mechanism 30 is in communication with each sample chamber 21 through the internal channel 12 and the connecting channel 171 of each connecting post 17. The present application designs the connecting channel 12 for connecting the driving mechanism 30 and each connecting post 17 inside the support 10, which avoids the problems of large arrangement difficulty, large volume and easy interference with other structures caused by externally connecting the connecting pipeline between the driving mechanism 30 and each connecting post 17, simplifies the structure of the biological detection device 1, and makes it more suitable for integration on a refrigerator or other household appliances.

[0049] Figure 7 and Figure 8 are schematic cross-sectional views of a biological detection chip according to an embodiment of the present application along different cross-sectional planes, Figure 9 is a schematic cross-sectional view of a biological detection chip mounted on a biological detection device according to an embodiment of the present application, Figure 10 is Figure 9An enlarged schematic view of the middle portion A. In some embodiments, the bio-detection chip 2 further comprises at least one reaction chamber 22 corresponding to and independent from each sampling chamber 21, for containing a reaction reagent, at least part of the peripheral wall of the reaction chamber 22 being a penetrable wall. The chip mounting portion 11 is further provided with a first piercing structure 51 having a first through channel 511 formed therein, for piercing the penetrable walls of the corresponding reaction chamber 22 and sampling chamber 21 after the bio-detection chip 2 is mounted to the chip mounting portion 11, and allowing fluid communication between the corresponding reaction chamber 22 and sampling chamber 21 through the first through channel 511. Specifically, the first piercing structure 51 can pierce the penetrable walls 221 of the reaction chamber 22 and the penetrable walls 211 of the sampling chamber 21 after the bio-detection chip 2 is mounted to the chip mounting portion 11, so that fluid communication is formed between the reaction chamber 22 and the sampling chamber 21 through the first through channel 511.

[0050] Further, the bio-detection chip 2 further comprises at least one detection chamber 23 corresponding to and independent from each sampling chamber 21, for containing a detection reagent, each detection chamber 23 having a liquid injection port 231 in communication with the interior thereof. The chip mounting portion 11 is further provided with a second piercing structure 52 having a second through channel 521 formed therein, for piercing the penetrable wall 222 of the corresponding reaction chamber 22 after the bio-detection chip 2 is mounted to the chip mounting portion 11, and allowing the reaction chamber 22 to communicate with the liquid injection port 231 of the corresponding detection chamber 23 through the second through channel 521. That is, the chip mounting portion 11 is further provided with the first piercing structure 51 and the second piercing structure 52, the interiors of the first piercing structure 51 and the second piercing structure 52 are respectively formed with the first through channel 511 and the second through channel 521, when the bio-detection chip 2 is mounted to the chip mounting portion 11, the penetrable walls of the sampling chamber 21 and the reaction chamber 22 can be pierced and fluid communication is formed therebetween by the first piercing structure 51, and the penetrable wall of the reaction chamber 22 can be pierced and fluid communication is formed between the reaction chamber 22 and the detection chamber 23 by the second piercing structure 52. In this way, the complex connecting pipeline is omitted, the structure is simplified, and the sampling chamber 21, the reaction chamber 22 and the detection chamber 23 of the bio-detection chip 2 can be arranged to be spaced apart, which is conducive to the long-term storage of the bio-detection chip 2 and allows the liquid reagent to be pre-stored in the sampling chamber, the reaction chamber or the detection chamber of the bio-detection chip 2.

[0051] Specifically, the sampling chamber 21, the reaction chamber 22, and the detection chamber 23 can be arranged in sequence along a preset direction to facilitate fluid communication between the sampling chamber 21 and the reaction chamber 22, and between the reaction chamber 22 and the detection chamber 23, thereby forming a detection channel 20. The number of the sampling chamber 21, the reaction chamber 22, and the detection chamber 23 can all be multiple, thereby forming a plurality of detection channels 20. The multiple detection channels 20 can be arranged in sequence along the width direction of the biological detection chip 2, and each detection channel 20 extends along the length direction of the biological detection chip 2, so that the layout on the biological detection chip 2 is more compact, thereby reducing the volume of the biological detection chip 2, making it more suitable for integration into household appliances.

[0052] In some embodiments, the driving mechanism 30 is a micro-injection pump that promotes the flow of fluid in the sampling chamber by pressing air into the sampling chamber. Specifically, the driving mechanism 30 may include a driving motor 31, a screw 32, a slider 33, a syringe 34 and a piston 35. The driving motor 31 is used to output driving force. The screw 32 is connected to the driving motor 31 so as to rotate under the drive of the driving motor 31. The slider 33 is passed through the screw 32 and is threadedly connected to the screw 32 so as to translate along the screw 32 as the screw 32 rotates. The first end of the syringe 34 is connected to the connecting channel 12. The piston 35 is arranged inside the syringe 34 and is fixedly connected to the slider 33 so as to move inside the syringe 34 driven by the slider 33, thereby promoting the flow of fluid in the sampling chamber 21 when it moves toward the first end of the syringe 34.

[0053] Furthermore, the end of the drive motor 31 facing away from the screw rod 32 and the circumferential side of the drive motor 31 are spaced apart from the bracket 10. That is to say, except for the end portion fixedly connected to the bracket 10, the other positions of the drive motor 31 are not in contact with the bracket 10. Thus, sufficient space is provided for the heat dissipation of the drive motor 31, which is conducive to the timely dissipation of the heat generated by it. In addition, the transmission of the vibration generated by the drive motor 31 during operation to other components on the bracket 10 (such as the biological detection chip installed in the chip mounting portion) is reduced to a certain extent, avoiding affecting other components.

[0054] In some embodiments, the biological detection device 1 further includes a position sensor 92, which is used to detect the position of the slider 33, so as to control the operation of the drive motor 31 through the position of the slider 33, thereby controlling the path of fluid flow in the detection channel by controlling the displacement of the piston 35 in the syringe 34, thereby facilitating monitoring the position of the piston 35 and the displacement of its movement, thereby achieving precise control of the fluid flow path.

[0055] In some embodiments, the biological detection device 1 further includes a circuit board 93, which is fixed to the bracket 10. Specifically, the circuit board 93 can be fixed to the upper portion of the bracket 10, in front of the drive mechanism 30. A plurality of claws 14 can extend forward from the upper portion of the bracket 10 to engage the circuit board 93 therewith.

[0056] Specifically, the position sensor 92 may be disposed on the circuit board 93 and electrically connected to the circuit board 93 .

[0057] In some embodiments, the biological detection device 1 also includes a front cover 91, which is arranged on the front side of the bracket 10, thereby covering at least part of the structure of the bracket 10, preventing the bracket 10, and the circuit board 93 and the driving mechanism 30 installed on the bracket 10 from being exposed on the front side of the biological detection device 1 and affecting its appearance.

[0058] Furthermore, a notch 911 is formed on the front cover 91 , and the chip mounting portion 11 is exposed to the front side of the front cover 91 through the notch 911 , so that the biological detection chip can be mounted on the chip mounting portion 11 through the notch 911 .

[0059] The present invention further provides a biological detection chip 2 suitable for being installed in the biological detection device 1 involved in any of the above embodiments.

[0060] See also Figures 7 to 10 The biological detection chip 2 has at least one sampling chamber 21 for containing the extraction liquid. The outside of each sampling chamber 21 is provided with a sampling port 24 for placing a solid sample. The sampling port 24 corresponds one-to-one with the position of the sample loading structure of the biological detection device 1, so that when the biological detection chip 2 is installed in the biological detection device 1, each sample loading structure 70 allows the solid sample placed on the corresponding sampling port 24 to be pushed into the corresponding sampling chamber 21.

[0061] Specifically, the sampling port 24 can be recessed toward the sampling chamber 21 to retain the solid sample therein and prevent it from falling. When there are multiple sampling chambers 21, there can also be multiple sampling ports 24. The multiple sampling ports 24 can be separated from each other to form multiple independent recesses. Alternatively, the multiple sampling ports 24 can be unseparated to form a single, complete recess.

[0062] In some embodiments, the sampling port 24 is separated from the corresponding sampling chamber 21 by a side wall 212 of the sampling chamber 21. The side wall 212 is configured to be at least partially permeable, so that when the biological detection chip 2 is installed in the biological detection device 1, the sample loading structure 70 allows the solid sample to penetrate the permeable wall of the sampling chamber 21 when pushing the solid sample, thereby allowing the solid sample to enter the sampling chamber 21 and be immersed in the extraction liquid.

[0063] In some embodiments, the biological detection chip 2 further comprises at least one reaction chamber 22 corresponding to and independent of each sampling chamber 21, for containing a reaction reagent, at least part of the peripheral wall of the reaction chamber 22 being a penetrable wall. The biological detection chip 2 further comprises at least one detection chamber 23 corresponding to and independent of each sampling chamber 21, for containing a detection reagent, each detection chamber 23 having a liquid injection port 231.

[0064] When the number of sampling chambers 21, reaction chambers 22 and detection chambers 23 is multiple, each sampling chamber 21, each reaction chamber 22 and each detection chamber 23 are isolated and independent of each other, so as to allow different types or different concentrations of extraction liquid to be pre-stored in each sampling chamber 21, allow different types of reaction reagents to be contained in each reaction chamber 22, and allow different types of detection reagents to be contained in each detection chamber 23.

[0065] When the number of sampling chambers 21, reaction chambers 22 and detection chambers 23 is multiple, the multiple sampling chambers 21 are on the same side of the biological detection chip 2, and the multiple detection chambers 23 are on the other side of the biological detection chip 2, so as to facilitate the user to observe the detection results of the multiple detection chambers 23 at the same time, which conforms to the user's usage habits.

[0066] Specifically, the biological detection chip 2 further comprises a body 40, and each detection channel 20 is formed on the body 40. The body 40 is generally cuboid, and the multiple detection chambers 23 are adjacent to the bottom of the body 40 and arranged side by side in the transverse direction.

[0067] Further, the sampling chamber 21 is pre-provided with an extraction liquid, so that the sample liquid is generated after the sample is placed in the sampling chamber 21 and mixed with the extraction liquid therein. In use, the user only needs to place the sample into the sampling port and install it to the chip mounting portion 11, and the sample enters the sampling chamber 21 under the pushing of the sample adding structure 70 and enters the extraction liquid, and the to-be-detected substance on the sample is dissolved into the extraction liquid to form a sample liquid with a suitable concentration, thereby saving the user from the tedious operation of manually preparing the sample liquid and improving the operation convenience of the user using the biological detection chip 2 for detection. The types and amounts of the extraction liquid in the sampling chambers 21 of different detection channels 20 can be the same or different according to needs.

[0068] In some embodiments, reaction chamber 22 is located between sampling chamber 21 and detection chamber 23, allowing the sample liquid in sampling chamber 21 to flow through reaction chamber 22 before flowing into detection chamber 23. That is, in the direction of fluid flow within detection channel 20, reaction chamber 22 is located downstream of sampling chamber 21 and upstream of detection chamber 23. For a specific sample liquid or for certain specific test parameters of the sample liquid, it is necessary to first react the sample liquid with a reaction reagent and then with a detection reagent. Placing the reaction reagent and detection reagent in different locations in reaction chamber 22 and detection chamber 23, respectively, can prevent reactions or mutual influences between the reaction reagent and detection reagent, thereby improving the accuracy of the test results.

[0069] In some embodiments, the reaction reagents are pre-installed in the reaction chamber 22 to avoid the trouble of manual addition of the reaction reagents by the user or to avoid the complicated structure caused by the automatic addition of the reaction reagents by the driving mechanism.

[0070] In some embodiments, the reaction reagent can be colloidal gold attached to the inner wall of the reaction chamber 22. The colloidal gold support arranged in this way is stable and not easy to move, so it is not easy to affect the sampling chamber 21 or the detection chamber 23, nor is it easily affected by the reagents in the sampling chamber 21 or the detection chamber 23.

[0071] In some embodiments, the detection reagent is pre-placed in the detection chamber 23 to avoid the troublesome operation caused by the user manually adding the detection reagent or to avoid the complicated structure caused by using a driving mechanism to automatically add the detection reagent.

[0072] In some embodiments, a test paper 60 is provided in the detection chamber 23 , and the detection reagent is integrated on the test paper 60 . At least one side of the detection chamber 23 is open or transparent to facilitate the user to observe the test results on the test paper 60 .

[0073] Of course, in some alternative embodiments, reaction reagents and detection reagents may be added to the reaction chamber 22 and detection chamber 23 respectively when the biological detection chip 2 is in use.

[0074] The following describes in detail a method for controlling a biological detection chip mounted on a biological detection device using the biological detection device. Figure 11 FIG. 1 is a schematic flow chart of a control method for a biological detection device according to an embodiment of the present invention. The control method may include:

[0075] Step S10, receiving a first trigger signal indicating that the biological detection chip 2 has been installed in the chip installation portion 11;

[0076] Step S20, waiting for a first preset time period to allow the substance to be detected on the sample to fully dissolve into the extract in the sampling chamber 21, thereby forming a sample solution of appropriate concentration;

[0077] Step S31 , starting the driving mechanism 30 , causing the sample liquid in the sampling chamber 21 of each detection channel 20 to flow to the reaction chamber 22 of the detection channel through the driving mechanism 30 ;

[0078] Step S32, determining whether the sample liquid flowing into the reaction chamber 22 has reached a preset sample volume; if so, proceeding to step S33; in this step, this can be achieved by detecting the position of the piston. When the piston moves to the preset position, it indicates that the sample liquid flowing into the reaction chamber 22 has reached the preset sample volume;

[0079] Step S33, stopping the driving mechanism 30;

[0080] Step S34: When the driving mechanism 30 stops for a second predetermined time, the driving mechanism 30 is restarted to cause the sample liquid in the reaction chamber 22 of each detection channel 20 to flow to the detection chamber 23 of the detection channel 20;

[0081] Step S40: After waiting for a third preset time, a prompt message is issued to indicate that the detection result has been displayed.

[0082] Furthermore, the control method of the present invention further includes:

[0083] When the second trigger signal for instructing the biological detection chip 2 to be removed from the chip mounting portion 11 is received, the piston of the control driving mechanism 30 is restored to the initial position.

[0084] The present invention also provides a refrigerator. Figure 12 is a schematic structural diagram of a refrigerator according to one embodiment of the present invention. Refrigerator 100 of the present invention includes a biological detection device 1 according to any of the aforementioned embodiments, with biological detection device 1 integrated into refrigerator 100. Refrigerator 100 may also include a biological detection chip 2 mounted on biological detection device 1. Refrigerators 100 are frequently used in daily life and are primarily used to store food. When biological detection device 1 is integrated into refrigerator 100, users can easily utilize biological detection device 1 to perform food sample detection operations.

[0085] Furthermore, refrigerator 100 includes a housing 200 and a door 300. Housing 200 defines a storage space, and door 300 is connected to housing 200 and is used to open and / or close the storage space. Biodetection device 1 is preferably mounted on door 300, which not only makes operation more convenient but also does not occupy the existing storage space within housing 200, thereby not affecting the storage capacity of refrigerator 100.

[0086] Figure 13is a schematic structural exploded view of a door body according to an embodiment of the present application. In some embodiments, the front side of the door body 300 is provided with a hollow window 301, and the chip mounting portion 11 is exposed to the front side of the door body 300 through the hollow window 301, so as to facilitate a user to install the biological detection chip 2 to implement a detection function without opening the door body 300, thereby ensuring the heat preservation performance of the refrigerator 100 and saving energy consumption.

[0087] Specifically, the door body 300 can include a panel 302 for forming a front portion thereof, a door lining 303 for forming a rear portion thereof, and a foamed heat preservation layer (not shown in the figure) arranged between the panel 302 and the door lining 303, and the hollow window 301 is formed in the panel 302. A pre-embedded box 304 is pre-embedded between the panel 302 and the door lining 303 before the foamed heat preservation layer is formed, and the biological detection device 1 is arranged in the pre-embedded box 304. That is, the pre-embedded box 304 is pre-arranged between the panel 302 and the door lining 303 before the door body 300 is foamed, and is used to reserve a space for mounting the biological detection device 1 between the panel 302 and the door lining 303.

[0088] Further, the pre-embedded box 304 is attached to the rear surface of the panel 302, and the front side of the pre-embedded box 304 is open and faces the hollow window 301, so as to allow the biological detection device 1 to be installed into the pre-embedded box 304 from front to back through the hollow window 301, thereby improving the convenience of installing the biological detection device 1.

[0089] Further, the mounting posture of the biological detection chip 2 in the chip mounting portion 11 is arranged such that each detection channel 20 formed thereby extends in a vertical direction. In this way, the user can conveniently install the biological detection chip 2, which conforms to the user's operation habit.

[0090] The refrigerator 100 of the present application is a refrigerator in a broad sense, which not only includes a refrigerator in a narrow sense as usually said, but also includes a storage device having a cold storage, a freezing or other storage function, such as a refrigerator, a refrigerator cabinet, etc.

[0091] Those skilled in the art should also understand that the terms "upper", "lower", "front", "rear", "top", "bottom", etc. used to indicate the orientation or positional relationship in the embodiments of the present application are based on the actual use state of the biological detection device 1 and the refrigerator 100, and these terms are only for the convenience of describing and understanding the technical solutions of the present application, and do not indicate or imply that the device referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present application.

[0092] At this point, those skilled in the art will recognize that, although a number of exemplary embodiments of the present invention have been shown and described in detail herein, many other variations or modifications consistent with the principles of the present invention may be directly determined or derived from the disclosure of the present invention without departing from the spirit and scope of the present invention. Therefore, the scope of the present invention should be understood and deemed to cover all such other variations or modifications.

Claims

1. A biological detection device for mounting a biological detection chip, wherein the biological detection chip has at least one sampling chamber for containing an extract, characterized in that: The biological detection device comprises: a bracket having a chip mounting portion for mounting the biological detection chip, the chip mounting portion being provided with at least one sample loading structure corresponding one-to-one to the sampling chamber, each sample loading structure being configured to push a solid sample placed outside the corresponding sampling chamber into the sampling chamber when the biological detection chip is mounted on the chip mounting portion, so that the solid sample is immersed in the extraction solution in the sampling chamber; The chip mounting portion is further provided with connecting posts corresponding to and adjacent to the sample loading structures. A connecting channel is defined within the connecting posts for penetrating the penetrable wall of the corresponding sampling chamber using the connecting posts after the biological detection chip is mounted on the chip mounting portion, thereby allowing the connecting channel within the connecting posts to communicate with the corresponding sampling chamber. a driving mechanism, the driving mechanism being disposed on the bracket and communicating with the connecting channel of each connecting post, so that after the biological detection chip is mounted on the chip mounting portion, the driving mechanism is communicated with each sampling chamber of the biological detection chip, thereby driving the flow of fluid in each sampling chamber in a controlled manner; The bioassay chip further includes at least one reaction chamber corresponding to and independent of the sampling chamber, for accommodating reaction reagents, and at least one detection chamber corresponding to and independent of the sampling chamber, for accommodating detection reagents; The sampling chamber, the reaction chamber and the detection chamber are arranged in sequence along a preset direction so as to form fluid communication between the sampling chamber and the reaction chamber, and between the reaction chamber and the detection chamber, thereby forming a detection channel.

2. The biological detection device according to claim 1, wherein The side wall of each sampling chamber for contacting the solid sample is configured to be at least partially permeable; and Each of the sample loading structures is configured to push the solid sample outside the corresponding sampling chamber and penetrate the penetrable wall of the sampling chamber when the biological detection chip is mounted on the chip mounting portion, so that the solid sample enters the sampling chamber.

3. The biological detection device according to claim 2, characterized in that The sample loading structure is a sample loading boss protruding toward the biological detection chip. The interior of the sample loading boss is hollow and is provided with a plurality of partition ribs arranged at intervals.

4. The biological detection device according to claim 2, wherein At least a portion of the peripheral wall of the reaction chamber is a permeable wall; and The chip mounting portion is also provided with a first piercing structure having a first through-channel formed therein, which is used to pierce the penetrable walls of the corresponding reaction chamber and the sampling chamber after the biological detection chip is mounted on the chip mounting portion, and allow fluid communication between the corresponding reaction chamber and the sampling chamber through the first through-channel.

5. The biological detection device according to claim 4, characterized in that Each of the detection chambers has a liquid injection port; The chip mounting portion is further provided with a second piercing structure having a second through-channel formed therein, which is used to pierce the penetrable wall of the corresponding reaction chamber after the biological detection chip is mounted on the chip mounting portion, and allow the reaction chamber to communicate with the liquid injection port of the corresponding detection chamber through the second through-channel.

6. A bioassay chip suitable for installation in the bioassay device according to any one of claims 1 to 5, characterized in that: The biological detection chip has at least one sampling chamber for containing an extract, and a sampling port for placing a solid sample is provided on the outside of each sampling chamber. The sampling ports correspond one-to-one with the positions of the sample loading structures of the biological detection device, so that when the biological detection chip is installed in the biological detection device, each sample loading structure is allowed to push the solid sample placed on the corresponding sampling port into the corresponding sampling chamber.

7. The biological detection chip according to claim 6, characterized in that: The sampling port is separated from the corresponding sampling chamber by a side wall of the sampling chamber, and the side wall is configured to be at least partially penetrable to allow the sample loading structure to penetrate the penetrable wall when pushing the solid sample when the biological detection chip is installed in the biological detection device, thereby allowing the solid sample to enter the sampling chamber.

8. The biological detection chip according to claim 6, characterized in that: There are multiple sampling chambers, and the multiple sampling chambers are isolated from each other.

9. A refrigerator, characterized in that: The biological detection device comprises any one of claims 1-5.

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