A vaccine atomization inhalation vaccination device and use method

Abstract

The present application relates to a vaccine atomization inhalation vaccination device and a method of use, wherein the vaccine atomization inhalation vaccination device comprises: a housing, in which a vaccine atomization component, an air extraction component and a mist storage bag are arranged, a sealed cabin for expanding the mist storage bag is arranged inside the housing, the air extraction component is connected to the sealed cabin, the vaccine atomization component can atomize the vaccine and inject the atomized vaccine into the mist storage bag. By atomizing and storing the vaccine in the mist storage bag, the cost of the atomization equipment can be reduced, and the way in which the air extraction component expands and opens the mist storage bag simplifies the injection operation, and the vaccine can be directly injected into the expanded mist storage bag after atomization, which is convenient for patients to atomize and inhale the vaccine.

Description

Technical Field

[0001] The present application relates to the field of medical device technology, and more specifically, to a vaccine atomization inhalation vaccination device and a method of use. Background Art

[0002] Nebulizer inhalation is a direct drug delivery method with the respiratory tract and lungs as target organs. It has the advantages of rapid onset, high local drug concentration, low dosage, convenient application and few systemic adverse reactions. It has been used as an important treatment for respiratory diseases. Nebulizer inhalation drugs are available in the form of sprays, aerosols, powder sprays and nebulizer inhalation solutions. Different nebulizer inhalation devices are used to deliver the drugs. At present, the main nebulizer inhalation devices are nebulizers (sprays), metered dose inhalers (aerosol delivery), dry powder inhalers (powder spray delivery) and nebulizers (nebulizer inhalation solution delivery). The nebulizer is a device that presses water into a thin tube to create a high-speed water flow. The high-speed water flow breaks into droplets after hitting an obstacle. Due to the large droplet size, it is only suitable for nasal spray administration. The metered dose inhaler is a delivery device that uses hand pressure to brake and quantitatively spray drug particles. The metered dose inhaler has the advantages of being easy to carry and simple to operate, but due to the use of gas propellants such as Freon, it is only suitable for small molecule drugs. A dry powder inhaler is a device that delivers powder aerosols to the respiratory tract driven by inhalation. Due to the mechanical crushing, spray drying and other processes currently used in the preparation of powder aerosols, factors such as shear force and high temperature have an adverse effect on the structure and activity of biological molecules. Currently, it is mostly suitable for small molecule drugs. However, with the development of technologies such as low-temperature freeze-drying, powder aerosols of biological macromolecules have become possible, but it is still in the conceptual development stage and the technology is not yet mature. A nebulizer is a device that atomizes the inhaled solution to form a mist that can reach the respiratory tract and alveoli. According to the working principle, it can be divided into ultrasonic, compressed air, and vibration mesh types. Ultrasonic nebulizers use ultrasonic directional pressure to make the liquid surface bulge, and cavitation occurs around the bulged liquid surface, atomizing the liquid into a small molecule aerosol. It has high power and delivery rate, but due to the heat generated during the atomization process, it is generally not suitable for the atomization of biological macromolecules such as proteins. Compressed air nebulizer is also called jet atomization. It uses compressed air to form a high-speed airflow through a small tube. The negative pressure generated drives the liquid or other fluid to be sprayed onto the obstruction. Under high-speed impact, the droplets are splashed around to turn into mist particles and spray out from the outlet pipe. Compressed air nebulizer is the most commonly used nebulizer at present. The nebulization rooms of domestic hospitals are basically equipped with compressed air nebulizers. Compressed air nebulizer has been used for the atomization inhalation of protein drugs such as α-chain dornase and interferon. However, due to the large shear force and foam caused by the high-speed circulation of the liquid in the nebulizer cup during the atomization process, there is a potential adverse effect on the stability of the protein, and specific adaptability studies need to be conducted on specific proteins. In addition, the compressed air nebulizer has the problem of non-uniformity during atomization output. The concentration of active substances in the atomized mist liquid varies, which is not suitable for continuous atomization output, nor is it suitable for the single loading and multiple uniform output required for vaccination. The mesh nebulizer is a device that squeezes the liquid through a sieve plate with tiny meshes through high-frequency vibration to form droplets.The power of the mesh nebulizer is small, there is less foam in the nebulizer cup, the liquid will not be repeatedly atomized in the nebulizer cup, and the effect on the structure and activity of the protein is small. Generally speaking, it is the most suitable nebulizer for protein drugs. In addition, new types of nebulization inhalation devices are also being developed. For example, the soft mist inhaler is a device that uses the mechanical energy generated by the compression spring of the rotating base as power to squeeze the drug through the screen to form an aerosol. In theory, it is more suitable for the atomization of protein drugs, but it requires the use of a special filling form, which requires major modifications to the existing preparation production line, and is not convenient for rapid promotion.

[0003] Although there are currently multiple protein drugs that are administered by inhalation in clinical practice, there is no vaccine that is administered by aerosol inhalation and has not yet been put into actual clinical use. The reason is that the problems of vaccination speed, cross-infection risk and economy brought about by large-scale vaccination have not yet been well solved. In 2006, the insulin powder aerosol for pulmonary inhalation jointly developed by Pfizer and Sanofi-Aventis was approved by the US FDA for marketing under the trade name Exubera. Although powder aerosols can be administered continuously multiple times with one device, the current vaccines are all in liquid dosage form, and the technology of converting them into powder aerosols by low-temperature freezing spray is not yet mature. In addition, it is reported that the aerosol inhalation COVID-19 vaccine jointly developed by CanSino and Academician Chen Wei of the Academy of Military Medical Sciences has completed the first phase of clinical trials. By directly changing the injection to aerosol inhalation administration, it has good effects and a small dosage. The relevant results have been published. It is used in the form of a nebulizer plus a fog storage cup. The volume of the fog storage cup is large, and the storage pressure on the vaccination point is large. In addition, it is difficult for the solid fog storage cup to completely inhale the aerosol during inhalation, and the delivered dose is uneven. In summary, there are currently public plans and examples of vaccination using vibration mesh atomization, but the current plans and methods do not address the actual needs of vaccination. Summary of the invention

[0004] The purpose of this application is to provide a vaccine atomization inhalation vaccination device and a method of use, which can reduce the cost of vaccine atomization inhalation vaccination, reduce the difficulty of operation, and facilitate large-scale vaccination.

[0005] In order to achieve the above-mentioned objectives, in a first aspect, the present invention provides a vaccine atomization inhalation vaccination device, comprising: a shell, in which a vaccine atomization component, an air extraction component and a mist storage bag are arranged, a sealed cabin for expanding the mist storage bag is arranged inside the shell, the air extraction component is connected to the sealed cabin, the vaccine atomization component can atomize the vaccine and inject the atomized vaccine into the mist storage bag.

[0006] In an optional embodiment, the shell includes a shell front cover and a shell rear cover, the exhaust assembly is arranged inside the shell rear cover, the sealed cabin is arranged inside the shell front cover, an exhaust hole is arranged on the shell front cover, and an exhaust duct is arranged between the exhaust assembly and the exhaust hole.

[0007] In an optional embodiment, a sealed hatch is hinged on the front cover of the shell, and the sealed hatch and the front cover of the shell are respectively provided with open grooves that can be snapped together, and a rubber sealing ring is provided between the hatch and the front cover of the shell, so that the open groove after snapping together constitutes the sealed cabin.

[0008] In an optional embodiment, the mist storage bag includes a flexible bag body and an infusion tube, the flexible bag body is accommodated in the sealed cabin, and the nozzle at the top of the infusion tube is exposed to the front cover of the shell and can be docked with the vaccine atomization assembly;

[0009] The top of the open groove is provided with a docking groove for clamping the perfusion pipe, and a rubber sealing pad is attached to the groove surface of the docking groove.

[0010] In an optional embodiment, a rotary valve and a snap-fitting convex ring matched with the docking groove are provided on the perfusion tube, the rotary valve is exposed on the front cover of the shell, and the snap-fitting convex ring is provided between the rotary valve and the flexible bag body.

[0011] In an optional embodiment, the vaccine atomization assembly is disposed inside a nebulizer hood, which is mounted on the top of the shell rear cover and disposed directly above the shell front cover, and the vaccine atomization assembly includes a mist outlet that can be docked with the infusion tube, and the nebulizer hood is connected to a control panel, which is provided with control buttons and indicator lights.

[0012] In an optional embodiment, the mist storage bag includes a plurality of bags, and the vaccine atomization assembly and the air extraction assembly include a plurality of sets corresponding to the mist storage bags;

[0013] The vaccine atomization component includes an atomizer and a semiconductor refrigerator for providing a low-temperature environment for atomized vaccines, and the air extraction component includes an air pump.

[0014] In an optional embodiment, a control unit is further included, and the control unit is electrically connected to the atomizer, the semiconductor refrigerator and the air pump respectively.

[0015] In an optional embodiment, the nebulizer is a mesh nebulizer.

[0016] In a second aspect, the present invention provides a method for using the vaccine aerosol inhalation vaccination device according to any one of the aforementioned embodiments, comprising the following steps:

[0017] Place the mist storage bag in the sealed cabin and turn on the air pump to expand the mist storage bag;

[0018] Connect the mist outlet of the nebulizer to the filling pipe of the mist storage bag, and turn on the nebulizer to allow the atomized vaccine to be filled into the mist storage bag;

[0019] Take out the mist bag from the sealed cabin and inhale all the gas in the mist bag into the lungs to complete the vaccination.

[0020] By atomizing the vaccine and storing it in a mist storage bag, the cost of the atomization equipment can be reduced. The way in which the vacuum component expands and opens the mist storage bag simplifies the filling operation. After atomization, the vaccine can be directly poured into the expanded mist storage bag, making it convenient for patients to receive atomized inhalation vaccination of the vaccine.

[0021] Other features and advantages of the present application will be described in detail in the subsequent specific implementation section. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present application and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0023] Figure 1 This is a schematic diagram of the structure of the vaccine aerosol inhalation vaccination device in this application;

[0024] Figure 2 This is a schematic diagram of the structure of the mist storage bag in this application;

[0025] Figure 3 This is a diagram showing the coordination relationship between the mist storage bag and the vaccine atomization inhalation vaccination device in this application;

[0026] Figure 4 This is a schematic diagram of the cross-sectional structure of the vaccine atomization inhalation vaccination device in this application.

[0027] icon:

[0028] 1-shell front cover; 11-sealed hatch; 12-sealed cabin; 13-open slot; 14-docking slot; 15-rubber sealing ring; 16-exhaust hole;

[0029] 2-shell rear cover;

[0030] 3- atomizing hood; 31- control button; 32- indicator light;

[0031] 4- vaccine atomization assembly; 41- mesh atomizer; 42- semiconductor refrigerator; 43- atomization cup; 44- atomization outlet;

[0032] 5-mist storage bag; 51-flexible bag body; 52-infusion tube; 53-screw valve; 54-clamping convex ring;

[0033] 6-air pump; 61-air extraction catheter. DETAILED DESCRIPTION

[0034] In order to make the purpose, technical scheme and advantages of the embodiments of the present application clearer, the technical scheme in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, rather than all of the embodiments. The components of the embodiments of the present application described and shown in the drawings here can be arranged and designed in various different configurations.

[0035] In the description of this application, it should be noted that the terms "inside", "outside", etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship in which the product of the application is usually placed when in use, which is only for the convenience of describing this application and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on this application. In addition, the terms "first", "second", etc. are only used to distinguish the description, and cannot be understood as indicating or implying relative importance.

[0036] In the description of this application, it should also be noted that, unless otherwise clearly specified and limited, the terms "disposed" and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a direct connection, or an indirect connection through an intermediate medium, or it can be the internal communication of two elements. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0037] See also Figure 1-Figure 4 The present application provides a vaccine atomization inhalation vaccination device, comprising: a shell, in which a vaccine atomization component 4, an exhaust component and a mist storage bag 5 are arranged, a sealed cabin 12 for expanding the mist storage bag 5 is arranged inside the shell, the exhaust component is connected to the sealed cabin 12, the vaccine atomization component 4 can atomize the vaccine and inject the atomized vaccine into the mist storage bag 5.

[0038] The vaccine atomization inhalation vaccination device of the present invention is mainly used for vaccination after atomization of the vaccine, specifically by filling the atomized vaccine into the mist storage bag 5 and allowing the patient to inhale the vaccine atomized gas in the mist storage bag 5 for vaccination.

[0039] The mist storage bag 5 can effectively reduce the vaccination cost of aerosolized vaccines and reduce the difficulty of operation. Compared with the existing storage tank, the mist storage bag 5 in a thin sheet state before use can reduce the storage volume of the mist storage bag 5.

[0040] The sealed cabin 12 inside the shell, combined with the air extraction component, can transform the mist storage bag 5, which is in a thin sheet state before use, into an expanded open state, which is convenient for the infusion of the atomized vaccine. By connecting the air extraction component with the sealed cabin 12, a vacuum state of the sealed cabin 12 can be formed, and the nozzle at the top of the mist storage bag 5 is exposed to the sealed cabin 12. The vacuum in the sealed cabin 12 can allow ambient air to enter the mist storage bag 5 from the nozzle at the top of the mist storage bag 5, thereby achieving the expansion of the mist storage bag 5. After the mist storage bag 5 is expanded and opened, the vaccine atomized by the vaccine atomization component 4 can be infused and filled into the mist storage bag 5 from the nozzle at the top of the mist storage bag 5, thereby facilitating the patient to inhale and vaccinate the atomized vaccine.

[0041] The extraction assembly and the mist storage bag 5 are respectively arranged at different parts of the shell. Specifically, the shell includes a shell front cover 1 and a shell rear cover 2. The shell front cover 1 is fixedly connected to the shell rear cover 2. The air extraction assembly is arranged inside the shell rear cover 2, and the sealed cabin 12 is arranged inside the shell front cover 1. Based on the functional requirement of exhausting air from the sealed cabin 12, an air extraction hole 16 is arranged on the shell front cover 1. The air extraction hole 16 is specifically arranged on the side wall inside the shell front cover 1, and an air extraction duct 61 is arranged between the air extraction hole 16 and the air extraction assembly.

[0042] In order to ensure that the sealed cabin 12 is isolated and sealed from the outside, a sealed cabin door 11 is hingedly connected to the shell front cover 1. The sealed cabin door 11 is specifically a swing door connected to the shell front cover 1. Open grooves 13 that can be docked and engaged with each other are respectively provided on the sealed cabin door 11 and the shell front cover 1. The docking parts of the two open grooves 13 have the same shape, so that the open grooves 13 after being engaged constitute the sealed cabin 12.

[0043] The internal space of the shell front cover 1 constitutes an open groove 13 on the shell front cover 1, and the open groove 13 on the sealing door 11 is a concave space of the sealing door 11. In order to ensure the sealing between the sealing door 11 and the shell front cover 1, a locking mechanism is also provided on the outside of the sealing door 11 and the shell front cover 1, which can make the two tightly combined together.

[0044] At the same time, in order to further ensure the sealing performance of the sealed cabin 12 after the open groove 13 is closed, a rubber sealing ring 15 is also arranged between the cabin door and the front cover 1 of the shell. Preferably, the rubber sealing ring 15 is installed on the outer contour of the open groove 13 on the front cover 1 of the shell, which helps to cover and seal the gap between the open grooves 13.

[0045] The mist storage bag 5 in the present invention is a mist storage bag 5 made of flexible material, including a flexible bag body 51 and an infusion tube 52 connected to the top of the flexible bag body 51. When in use, the flexible bag body 51 is accommodated in the sealed cabin 12, the infusion tube 52 is clamped between the sealed cabin door 11 and the shell front cover 1, and the pipe opening at the top of the infusion tube 52 is exposed to the shell front cover 1.

[0046] The nozzle at the top of the infusion tube 52 mainly plays the role of allowing air to enter the mist storage bag 5 in the expansion process and infusing the atomized vaccine. This requires that a part of the infusion tube 52 be clamped between the sealed cabin door 11 and the shell front cover 1, so that the nozzle at the top of the infusion tube 52 is exposed, and at the same time plays the role of fixing the mist storage bag 5. The top of the open groove 13 on the shell front cover 1 and the sealed cabin door 11 is provided with a docking groove 14 for clamping the infusion tube 52. The docking groove 14 is specifically a semicircular groove of a certain length. A rubber sealing pad is attached to the groove surface of the docking groove 14. When the infusion tube 52 is clamped, an effective seal can be formed at the docking groove 14 through the rubber sealing pad to ensure the sealing inside the sealed cabin 12.

[0047] Based on the different functions of the perfusion tube 52 mentioned above, a rotary valve 53 and a snap-on convex ring 54 matched with the docking groove 14 are provided on the perfusion tube 52. The rotary valve 53 mainly controls the on-off of the perfusion tube 52. Specifically, when the air is pumped out for expansion and the atomized vaccine is injected, the rotary valve 53 is in an open state to allow external ambient air to enter the mist storage bag 5 to expand and open it, and to inject the atomized vaccine into the expanded and opened mist storage bag 5.

[0048] The clamping convex ring 54 is mainly used to fix the infusion tube 52 on the docking groove 14, and then fix the mist storage bag 5. The assembled docking groove 14 can clamp the clamping convex ring 54 on the infusion tube 52 to fix the infusion tube 52 and the mist storage bag 5. The clamping convex ring 54 can be in close contact with the rubber sealing gasket to achieve effective sealing.

[0049] From the perspective of convenient operation of the rotary valve 53 , the rotary valve 53 is exposed on the housing front cover 1 after being fixed, and the clamping convex ring 54 is specifically arranged between the rotary valve 53 and the flexible bag body 51 , so that the rotary valve 53 can be easily screwed.

[0050] The vaccine atomization assembly 4 in the present invention is arranged inside the atomization hood 3, and the atomization hood 3 is installed on the top of the shell rear cover 2 and is arranged directly above the shell front cover 1, so that the atomized vaccine can be directly infused and filled into the mist storage bag 5. The vaccine atomization assembly 4 includes a nebulizer and a mist outlet pipe connected to the nebulizer, and a trumpet-shaped mist outlet 44 is provided at the end of the mist outlet pipe. The mist outlet 44 is connected to the pipe mouth at the top of the infusion pipe 52 up and down, so that the atomized vaccine can be conveniently filled into the mist storage bag 5.

[0051] In order to facilitate the operation of the atomizer, a control panel is connected to the atomizer cover 3, and a control button 31 and an indicator light 32 are provided on the control panel. By operating the control button 31, the start and stop of the atomizer can be controlled, and the indicator light 32 can display the operating state of the atomizer, which is convenient for operation.

[0052] From the perspective of improving the filling efficiency of the fog storage bag 5, the fog storage bag 5 in the present invention can be provided in plurality, and the vaccine atomization assembly 4 and the air extraction assembly include multiple sets corresponding to the fog storage bag 5. A plurality of sealed cabins 12 can be provided inside the front cover 1 of the shell, and by combining the sealed cabins 12 with the air extraction assembly, the fog storage bag 5 and the vaccine atomization assembly 4, atomization of multiple nebulizers can be performed simultaneously, thereby improving the flux of vaccine atomization.

[0053] The vaccine atomization component 4 includes an atomizer and a semiconductor refrigerator 42 for providing a low-temperature environment for atomized vaccines, and the air extraction component includes an air pump 6 .

[0054] From the perspective of easy control, the vaccine atomization inhalation vaccination device of the present invention also includes a control unit, which is electrically connected to the atomizer, semiconductor refrigerator 42 and air pump 6 respectively. The control unit can control the air pump 6 and the atomizer to work according to the set program, automatically complete the air extraction and atomization, and is convenient to operate in combination with the control button 31 and the indicator light 32. Specifically, the control unit can control the working order and duration of the air pump 6 and the atomizer, and can display the completion of atomization through the indicator light 32 and prompt to remove the mist storage bag 5.

[0055] The materials of the shell body and the sealed hatch 11 include but are not limited to stainless steel, organic glass and glass. The form of the atomizer can be an active mesh atomizer 41, a passive mesh atomizer 41, a compressed air atomizer, an ultrasonic atomizer, and a soft mist atomizer, among which the passive mesh atomizer 41 and the soft mist atomizer are preferred. When the atomizer is a mesh atomizer 41, the material of the mesh atomizer 41 vibration mesh includes but is not limited to titanium alloy, manganese alloy and stainless steel, among which titanium alloy is preferred, which can maintain the biological activity of the vaccine itself. The operating frequency of the mesh atomizer 41 is 100kHz-150kHz, and the aperture of the vibration mesh is 1μm-10μm. During the atomization process of the vaccine, the median particle size of the droplets output by the mesh atomizer 41 is 1μm-20μm, among which 2μm-10μm is preferred; the speed of outputting droplets is 0.1ml / min-2ml / min, among which 0.2ml / min-1ml / min is preferred. The amount of medicine loaded in the atomizing cup 43 of the mesh atomizer 41 is 1 ml-100 ml, preferably 5 ml-20 ml; the service life of the mesh atomizer 41 is 1 min-1000 min, or atomizing 1 ml-1000 ml.

[0056] The material of the flexible bag body 51 of the mist storage bag 5 can be polyethylene (PE), high-density polyethylene (HDPE), low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), polypropylene (PP), polyvinyl chloride (PVC), vinyl acetate (EVA), polyethylene + vinyl acetate (PE + EVA mixture), polyethylene coated with polypropylene (PE / PP), latex and paper.

[0057] From the perspective of convenient storage of the mist storage bag 5, the mist storage bag 5 is in a folded or compressed sheet state before use to reduce the occupied space, and its capacity after being fully inflated and unfolded is 100ml-2000ml, preferably 200-1000ml. The diameter of the perfusion tube 52 at the top of the mist storage bag 5 is 0.5cm-5cm, preferably 1cm-2cm.

[0058] The vacuum assembly in the present invention can be an electric air pump 6, or a manual vacuum pipe or vacuum cylinder, which can be flexibly adjusted according to specific use conditions, and it is required to make the sealed cabin 12 in a vacuum state after vacuuming. Preferably, a negative pressure of 0.01 bar-1 bar is generated in the sealed cabin 12 and maintained for more than 0.5 minutes, and the volume of the sealed cabin 12 is 200 ml-5000 ml.

[0059] The vaccine atomization inhalation vaccination device of the present invention facilitates the vaccination operation by atomizing the vaccine and then pouring it into the mist storage bag 5, and allowing the patient to inhale the atomized vaccine in the mist storage bag 5, which can greatly improve the vaccination efficiency and reduce the cost of the vaccination equipment.

[0060] The present invention also provides a method for using the above vaccine atomization inhalation vaccination device, comprising the following steps:

[0061] Open the sealed door 11 on the front cover 1 of the housing, put the mist storage bag 5 into the sealed cabin 12, accommodate the flexible bag body 51 in the sealed cabin 12, and connect the perfusion tube 52 to the docking groove 14, close and lock the sealed door 11, so that the sealed cavity of the sealed cabin 12 is isolated from the outside;

[0062] Press the control button 31 to start the air pump 6, the air pressure in the sealed cabin 12 decreases, and the rotary valve 53 on the perfusion pipe 52 is opened, and the ambient air enters the mist storage bag 5 through the perfusion pipe 52. The flexible bag body 51 of the mist storage bag 5 expands to a predetermined volume under the negative pressure of the sealed cabin 12 and stops working;

[0063] The mist outlet 44 at the bottom of the atomizer is connected to the pipe opening at the top of the perfusion pipe 52, and the vaccine liquid is atomized into the mist storage bag 5 below according to the predetermined volume, and then the atomization is stopped;

[0064] Close the rotary valve 53 on the perfusion tube 52, open the sealed cabin door 11, take out the mist storage bag 5 and immediately give it to the person to be vaccinated for inhalation vaccination, and do not store it;

[0065] The inoculated population contains the perfusion tube 52 of the mist bag 5, opens the rotary valve 53, takes a deep breath slowly, inhales all the gas in the mist bag 5 into the lungs, and holds the breath for more than 10 seconds, and the vaccination is completed;

[0066] The cycle continues in sequence, and the next person to be vaccinated begins the aerosol inhalation vaccination process.

[0067] In a specific embodiment of the vaccine atomization inhalation vaccination device of the present invention, the mist storage bag 5 is similar to the currently common nozzle bag and is in a non-inflated compressed state before use. The flexible bag body 51 is made of PP polypropylene material and can accommodate a volume of 500 ml. The perfusion tube 52 and the rotary valve 53 are made of polyethylene terephthalate PET material, and the inner diameter of the tube is 1 cm and the outer diameter is 1.1 cm. The rotary valve 53 is in an open state before use. After the atomized vaccine is loaded, the rotary valve 53 is closed and the sealed cabin door 11 is opened to take out the mist storage bag 5 to prevent the atomized vaccine from escaping. After the vaccinated population contains the mist storage bag 5, the rotary valve 53 is opened to inhale the atomized vaccine.

[0068] The atomizer in this embodiment is a mesh atomizer 41, the maximum charge of the atomizer cup 43 of the mesh atomizer 41 is 15 ml, the vibration net is made of titanium alloy, the diameter of the vibration net is 0.6 cm, and 1500 micropores are punched by laser drilling process, and the diameter of the micropores is 2 μm. The operating frequency of the atomizer is 130 kHz, and it can output droplets with a median particle size of 2 μm-5 μm at a speed of about 0.5 ml / min, and its service life can reach 1000 min.

[0069] The mesh atomizer 41 is equipped with a small semiconductor refrigerator 42, which is located in the device as shown in FIG. Figure 4 The semiconductor refrigerator 42 adopts a mature product solution currently used in electrical appliances such as car refrigerators, and is composed of a cooling plate, a heat sink, a cooling fan, a circuit board, etc., which can maintain the atomizing cup 43 of the mesh atomizer 41 at a low temperature environment of more than 10° below the room temperature.

[0070] The air pump 6 for extracting air is a micro air pump 6, and the configured micro air pump 6 adopts a mature product of a fish tank oxygen pump 6 or similar products. The air pump 6 extracts air from the sealed cabin 12 to expand the compressed mist storage bag 5 to a predetermined volume. In this embodiment, the volume of the sealed cabin 12 is 1000ml.

[0071] The control unit in this embodiment includes a PLC control chip, which is arranged inside the shell. The PLC control chip controls the working sequence and duration of the air pump 6 and the atomizer through a set program, and can indicate through the indicator light 32 that atomization has been completed and prompt to remove the mist storage bag 5.

[0072] When in use, open the sealed door 11 of the front cover 1 of the housing, put the mist bag 5 into the sealed cabin 12, the flexible bag body 51 is contained in the sealed cabin 12, the perfusion tube 52 is connected to the docking groove 14, close and lock the sealed door 11, and isolate the sealed cavity of the sealed cabin 12 from the outside. Press the control button 31, the program in the PLC control chip controls the air pump 6 to start for about 1 minute, the pressure in the sealed cabin 12 drops, the mist bag 5 expands to a predetermined volume under negative pressure, and the air pump 6 stops working. The nebulizer starts to work, atomizing 0.1ml-0.5ml vaccine liquid to the mist bag 5 below at a speed of 0.5ml / min, and then stops atomization. Rotate and close the rotary valve 53 on the perfusion tube 52, open the sealed door 11, and take out the mist bag 5. Immediately hand the mist bag 5 to the person to be vaccinated, the person to be vaccinated slowly and deeply inhales 500ml of mist into the lungs, and holds his breath for more than 10s to complete the vaccination.

[0073] The inoculation method of the present invention has the characteristics of simple structure and convenient operation. The existing storage tank can be replaced by the mist storage bag 5, which greatly reduces the inoculation cost, and can prevent cross infection during the reuse of the storage tank, effectively improving the inoculation efficiency.

[0074] It should be noted that, in the absence of conflict, the features in the embodiments of this application may be combined with each other.

[0075] The above description is only the preferred embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A vaccine atomization inhalation vaccination device, characterized in that: The invention comprises: a shell, in which a vaccine atomization component, an air extraction component and a mist storage bag are arranged, a sealed cabin for expanding the mist storage bag is arranged inside the shell, the air extraction component is connected with the sealed cabin, and the vaccine atomization component can atomize the vaccine and inject the atomized vaccine into the mist storage bag; The volume of the mist storage bag is smaller than the volume of the sealed cabin; The shell comprises a shell front cover and a shell rear cover, a sealed hatch is hinged on the shell front cover, and the sealed hatch and the shell front cover are respectively provided with open grooves that can be buckled; The mist storage bag comprises a flexible bag body and an infusion tube, wherein the flexible bag body is accommodated in the sealed cabin, and the nozzle at the top of the infusion tube is exposed to the front cover of the shell and can be docked with the vaccine atomization assembly; The top of each open groove is provided with a docking groove for clamping the perfusion pipe, and a rubber sealing pad is attached to the groove surface of the docking groove; The perfusion pipe is provided with a screw valve and a clamping convex ring adapted to the docking groove, the screw valve is exposed on the front cover of the housing, the clamping convex ring is arranged between the screw valve and the flexible bag body, the docking groove after splicing can clamp the clamping convex ring on the perfusion pipe to fix the perfusion pipe and the mist storage bag, and the clamping convex ring can be in close contact with the rubber sealing pad on the groove surface of the docking groove; The mist storage bags include a plurality of bags, and the vaccine atomization assembly and the air extraction assembly include a plurality of sets corresponding to the mist storage bags; When in use, the flexible bag body is contained in the sealed cabin, the filling tube is clamped between the sealed cabin door and the front cover of the shell, and the tube opening at the top of the filling tube is exposed to the front cover of the shell; The method of use includes the following steps: Place the mist storage bag in the sealed cabin and turn on the air pump to expand the mist storage bag; Connect the mist outlet of the nebulizer to the filling pipe of the mist storage bag, and turn on the nebulizer to allow the atomized vaccine to be filled into the mist storage bag; Take out the mist bag from the sealed cabin, place the infusion tube of the mist bag in the vaccination population, open the rotary valve, and inhale all the gas in the mist bag into the lungs to complete the vaccination.

2. The vaccine atomization inhalation vaccination device according to claim 1, characterized in that: The air extraction component is arranged inside the rear cover of the shell, the sealed cabin is arranged inside the front cover of the shell, an air extraction hole is arranged on the front cover of the shell, and an air extraction duct is arranged between the air extraction component and the air extraction hole.

3. The vaccine atomization inhalation vaccination device according to claim 2, characterized in that: A rubber sealing ring is arranged between the hatch and the front cover of the shell body so that the open groove after buckling forms the sealed cabin.

4. The vaccine atomization inhalation vaccination device according to claim 1, characterized in that: The vaccine atomization assembly is arranged inside the atomization hood, and the atomization hood is installed on the top of the rear cover of the shell and is arranged directly above the front cover of the shell. The vaccine atomization assembly includes a mist outlet that can be connected to the perfusion tube. The atomization hood is connected to a control panel, and the control panel is provided with control buttons and indicator lights.

5. The vaccine atomization inhalation vaccination device according to any one of claims 1 to 4, characterized in that: The vaccine atomization component includes an atomizer and a semiconductor refrigerator for providing a low-temperature environment for atomized vaccines, and the air extraction component includes an air pump.

6. The vaccine atomization inhalation vaccination device according to claim 5, characterized in that: It also includes a control unit, which is electrically connected to the atomizer, the semiconductor refrigerator and the air pump respectively.

7. The vaccine atomization inhalation vaccination device according to claim 5, characterized in that: The atomizer is a mesh atomizer.

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