A blood sample analyzer

Abstract

The application provides a blood sample analyzer, comprising: an assay component for performing an item test on a blood sample to be tested to obtain a test result; a sample component for carrying the blood sample to be tested and providing the blood sample to the assay component after the blood sample is taken; a sensor for collecting an environmental parameter of an environment in which the blood sample analyzer is located; and a processor configured to implement the following steps when executing one or more programs: receiving the environmental parameter measured by the sensor; and correcting the test result based on the environmental parameter to obtain a corrected result. According to the application, the environmental parameter of the environment in which the blood sample analyzer is located is detected, the test result is corrected based on the environmental parameter, and the accuracy of the test is improved; or the alarm value range of the test is determined based on the environmental parameter, and the reliability of the test is improved.

Description

Technical Field

[0001] This application relates to the field of medical technology, and more specifically to blood sample analysis technology. Background Technology

[0002] When analyzing and testing blood samples, it is sometimes necessary to mix or react reagents with the blood sample to perform the test, such as to test the content of a target analyte. Because the entire testing process is sensitive to changes in the external environment, such as the reagents used, fluctuations in the testing environment, or human factors, these can all lead to significant errors in the test results, reducing the accuracy of the test. Furthermore, they can affect the range of detectable target analyte content, resulting in situations where the actual content is high but the measured result is low, thus reducing the sensitivity of the test. Summary of the Invention

[0003] This application provides a blood sample analyzer to at least solve one of the above-mentioned problems.

[0004] According to a first aspect of this application, a blood sample analyzer is provided, comprising:

[0005] The measuring component is used to perform tests on the blood sample to be tested in order to obtain test results;

[0006] A sample component is used to hold the blood sample to be tested and to provide the blood sample to the measuring component after aspirating the blood sample.

[0007] Sensors are used to collect environmental parameters of the environment in which the blood sample analyzer is located;

[0008] A processor, configured to perform the following steps when executing one or more programs:

[0009] Receive the environmental parameters measured by the sensor;

[0010] The test results are corrected based on the environmental parameters to obtain the correction results.

[0011] Optionally, the test results are corrected based on the environmental parameters to obtain a correction result, including:

[0012] The environmental parameters are smoothed to obtain smoothed environmental parameter data;

[0013] The deviation of the test results for the project is calculated based on the smoothed environmental parameter data.

[0014] The correction result is obtained based on the test results and the deviation from the results.

[0015] Optionally, the deviation of the project test results is calculated based on the smoothed environmental parameter data, including:

[0016] The stability of the test environment during the first time period is determined based on the changes in the first environmental parameters during the first time period, wherein the first time period includes the project test period;

[0017] If the test environment is stable, the result deviation is calculated based on the first environmental parameter and the second environmental parameter of the blood sample analyzer during a second time period, wherein the second time period includes the calibration period;

[0018] If the test environment is unstable, the result deviation is calculated based on the test deviation in the first time period and the calibration deviation in the second time period.

[0019] Optionally, if the testing environment is stable, the result deviation is calculated based on the first environmental parameter and the second environmental parameter of the blood sample analyzer during the second time period, including:

[0020] The result deviation includes reagent parameter deviation and environmental parameter deviation. The reagent parameter deviation includes the parameter deviation between the reagents used in the first time period and the reagents used in the second time period. The environmental parameter deviation is proportional to the difference between the first environmental parameter and the second environmental parameter.

[0021] Optionally, if the testing environment is stable, the result deviation is calculated based on the first environmental parameter and the second environmental parameter of the blood sample analyzer during the second time period, including:

[0022] The blood sample analyzer was calibrated a second time before the aforementioned test was conducted.

[0023] The result deviation is proportional to the difference between the first environmental parameter and the third environmental parameter of the blood sample analyzer during the third time period, wherein the third time period includes the secondary calibration period.

[0024] Optionally, determining whether the test environment is stable within the first time period based on changes in the first environmental parameter within the first time period includes:

[0025] Determine whether the change of the first environmental parameter in the first sub-time period of the first time period exceeds the change threshold, wherein the first sub-time period is before the start of the project test;

[0026] If the change does not exceed the change threshold, the test environment is determined to be stable.

[0027] If the change exceeds the change threshold, the test environment is determined to be unstable.

[0028] Optionally, if the testing environment is unstable, the result deviation is calculated based on the testing deviation during the first time period and the calibration deviation of the blood sample analyzer during a second time period, including the calibration period, including:

[0029] The stability of the calibration environment in the second time period is determined based on the changes of the second environmental parameter in the second sub-time period of the second preset time period, wherein the second sub-time period is before the start of the calibration.

[0030] If the calibration environment is stable, the test deviation is calculated based on the first environmental parameter that exceeds the change threshold during the first time period, and the calibration deviation is calculated based on the second environmental parameter and the reference environmental parameter.

[0031] If the calibration environment is unstable, the test deviation is calculated based on a first environmental parameter that exceeds the change threshold during the first time period, and the calibration deviation is calculated based on a second environmental parameter that exceeds the change threshold during the second time period.

[0032] The result deviation includes the difference between the test deviation and the calibration deviation.

[0033] Optionally, the test deviation is calculated based on a first environmental parameter that exceeds the change threshold during the first time period, including:

[0034] Divide the first time period into n sub-test time periods, and determine whether the change of the first environmental parameter in each sub-test time period exceeds the change threshold, where n is a positive integer;

[0035] Calculate the average value Cm of the first environmental parameter within m sub-test time periods that exceed the change threshold, where m is a positive integer less than n;

[0036] The test deviation is obtained based on the baseline environmental parameter C0, the experimental environmental parameter C, the m average values ​​Cm, and the component functions associated with the average values ​​Cm.

[0037] Optionally, the calibration deviation is calculated based on the second environmental parameter and the reference environmental parameter, including:

[0038] The calibration deviation includes reagent parameter deviation and environmental parameter deviation. The reagent parameter deviation includes the parameter deviation between the reagents used in the first time period and the reagents used in the second time period. The environmental parameter deviation is proportional to the difference between the second environmental parameter and the reference environmental parameter.

[0039] Optionally, the calibration deviation is calculated based on a second environmental parameter that exceeds the change threshold during the second time period, including:

[0040] The second time period is divided into p sub-calibration time periods, and it is determined whether the change of the second environmental parameter in each sub-calibration time period exceeds the change threshold, where p is a positive integer;

[0041] Calculate the average value Cq of the second environmental parameter within q sub-calibration time periods that exceed the change threshold, where q is a positive integer less than p;

[0042] The calibration deviation is obtained based on the baseline environmental parameter C0, the experimental environmental parameter C, q average values ​​Cq, and the component functions associated with the average values ​​Cq.

[0043] Optionally, the environmental parameters include water sample results. The test results are corrected based on the environmental parameters to obtain a corrected result, including:

[0044] Obtain the deviation of water sample results obtained by testing the project using water samples;

[0045] The test result deviation of the project is obtained based on the deviation of the water sample results;

[0046] The correction result is obtained based on the test results and the deviation from the results.

[0047] Optionally, the blood sample analyzer further includes:

[0048] A display device is used to display the test results and / or the correction results.

[0049] Optionally, the processor is further configured to:

[0050] The display device is controlled to display the test results and prompts the operator whether to display the correction results.

[0051] Optionally, the processor is further configured to:

[0052] Determine whether the correction result is within the preset alarm value range;

[0053] If the correction result is not within the preset alarm value range, then the sample is determined to be abnormal;

[0054] An alarm will be triggered when the sample is abnormal.

[0055] Optionally, the environmental parameters include at least one of ambient air pressure, ambient temperature, ambient humidity, water quality parameters, and gas content parameters.

[0056] Optionally, the water quality parameters include at least one of resistivity, conductivity, pH, and concentration of substances in the water.

[0057] Optionally, the gas content parameter includes at least one of oxygen concentration, carbon dioxide concentration, and dust concentration.

[0058] According to a second aspect of this application, a blood sample analyzer is provided, comprising:

[0059] The measuring component is used to perform tests on the blood sample to be tested in order to obtain test results;

[0060] A sample component is used to hold the blood sample to be tested and to provide the blood sample to the measuring component after aspirating the blood sample.

[0061] Sensors are used to collect environmental parameters of the environment in which the blood sample analyzer is located;

[0062] A processor, configured to perform the following steps when executing one or more programs:

[0063] Receive the environmental parameters from the sensor, wherein the environmental parameters include at least one of ambient air pressure, ambient temperature, ambient humidity, water quality parameters, and gas content parameters;

[0064] The preset alarm value range is determined based on the environmental parameters;

[0065] Determine whether the test result is within the preset alarm value range to determine whether the blood sample is abnormal.

[0066] Optionally, determining a preset alarm value range based on the environmental parameters includes:

[0067] Based on the unit volume content of the target item under the environmental parameters and the total volume of the mixture of the blood sample and the reagent, the content of the target item in the mixture is obtained;

[0068] The upper limit of the preset alarm value range is obtained based on the content of the target item in the mixed liquid and the volume of the blood sample;

[0069] The preset alarm value range is determined based on the upper limit value.

[0070] According to a third aspect of this application, a blood sample analyzer is provided, comprising:

[0071] The measuring component is used to perform tests on the blood sample to be tested in order to obtain test results;

[0072] A sample component is used to hold the blood sample to be tested and to provide the blood sample to the measuring component after aspirating the blood sample.

[0073] Sensors are used to collect environmental parameters of the environment in which the blood sample analyzer is located;

[0074] A processor, configured to perform the following steps when executing one or more programs:

[0075] Receive the environmental parameters from the sensor;

[0076] Determine whether the test result is within the preset alarm value range to determine whether the blood sample is abnormal, wherein the test result of the project test is corrected based on the environmental parameters, or the preset alarm value range is determined.

[0077] According to the embodiments of this application, the blood sample analyzer detects environmental parameters of its environment and corrects the test results based on these environmental parameters to improve the accuracy of the test; or determines the alarm value range of the test based on these environmental parameters to improve the reliability of the test. Attached Figure Description

[0078] The above and other objects, features, and advantages of this application will become more apparent from the more detailed description of the embodiments of this application in conjunction with the accompanying drawings. The accompanying drawings are used to provide a further understanding of the embodiments of this application and form part of the specification. They are used together with the embodiments of this application to explain this application and do not constitute a limitation thereof. In the accompanying drawings, the same reference numerals generally represent the same components or steps.

[0079] Figure 1 This is a schematic structural block diagram of a blood sample analyzer according to an embodiment of this application. Detailed Implementation

[0080] To make the objectives, technical solutions, and advantages of this application more apparent, exemplary embodiments according to this application will be described in detail below with reference to the accompanying drawings. Obviously, the described embodiments are merely some embodiments of this application, and not all embodiments of this application. It should be understood that this application is not limited to the exemplary embodiments described herein. Based on the embodiments of this application described herein, all other embodiments obtained by those skilled in the art without inventive effort should fall within the protection scope of this application.

[0081] In blood sample analysis techniques, some tests are highly sensitive to changes in the external environment. For example, reagents for tests involving substance A (such as CO2) are easily affected by the concentration of substance A in the environment (e.g., CO2 concentration). Even small fluctuations in the concentration can lead to significant result deviations. Because testing environments vary across locations, some environments are relatively enclosed. Increased personnel can cause CO2 concentrations to rise continuously, even reaching high levels, affecting alkaline reagents such as FUN and Mg. Furthermore, movement of people and opening / closing doors and windows cause changes in air circulation, leading to large fluctuations in CO2 concentrations and inconsistent test results, resulting in inaccurate readings and reduced test accuracy. Blood sample analyzers in these technologies also fail to collect environmental parameter data, do not monitor environmental parameters in real time, cannot calculate and correct for the impact of environmental parameter changes on the test results, and cannot issue timely and effective alarms.

[0082] Based on the above considerations, this application provides a blood sample analyzer. See also Figure 1 , Figure 1 A schematic structural block diagram of a blood sample analyzer according to an embodiment of this application is shown. Figure 1 As shown, the blood sample analyzer 100 may include:

[0083] The measuring component 110 is used to perform tests on the blood sample to be tested in order to obtain test results;

[0084] The sample component 120 is used to hold the blood sample to be tested and to provide the blood sample to the measuring component after aspirating the blood sample;

[0085] Sensor 130 is used to collect environmental parameters of the environment in which the blood sample analyzer is located;

[0086] Processor 140, when configured to execute one or more programs, performs the following steps:

[0087] Step S110: Receive environmental parameters measured by the sensor;

[0088] Step S120: Correct the test results based on environmental parameters to obtain the correction results.

[0089] By monitoring environmental parameters using sensors and adjusting the test results based on changes in these parameters, the accuracy of the test results is improved. This method is suitable for a wide range of applications in blood sample analysis.

[0090] Optionally, see Figure 1The measuring component 110 may include a reaction component 111 and a photometric component 112. The reaction component 111 has at least one placement position for placing a reaction cup and incubating the reaction liquid within it. For example, the reaction component 111 may be a reaction disk, which has a disk-shaped structure and one or more placement positions for placing reaction cups. The reaction disk is rotatable and drives the reaction cups in its placement positions to rotate, thereby managing the reaction cups and incubating the reaction liquid within the reaction disk. The photometric component 112 is used to perform photometric measurements on the incubated reaction liquid to obtain the sample's reaction data. For example, the photometric component 112 detects the luminescence intensity of the reaction liquid to be tested and calculates the concentration of the analyte in the sample using a calibration curve. In one embodiment, the photometric component 112 is separately disposed outside the reaction component 111.

[0091] Optionally, see Figure 1 The sample component 120 may include a sample carrying component 121 and a sample dispensing mechanism 122. The sample carrying component 121 is used to carry samples. In some examples, the sample carrying component 121 may include a sample delivery module (SDM) and a front-end track; such as... Figure 1 As shown, the sample carrying component 121 can also be a sample tray, which includes multiple sample positions for placing sample tubes. By rotating its tray structure, the sample can be moved to the corresponding position, such as the position for the sample dispensing mechanism 122 to pick up the sample. The sample dispensing mechanism 122 is used to pick up the sample and dispense it into the reaction cup to be added. For example, the sample dispensing mechanism 122 may include a sample needle, which is driven by a two-dimensional or three-dimensional mechanism to move in two-dimensional or three-dimensional space, so that the sample needle can move to pick up the sample carried by the sample carrying component 121, move to the reaction cup to be added, and dispense the sample into the reaction cup.

[0092] Optionally, sensor 130 may include one or more of the following: a pressure sensor, a temperature sensor, a humidity sensor, a water quality parameter sensor, and a gas concentration sensor. In some embodiments, the gas concentration sensor may include an oxygen sensor, and / or a carbon dioxide sensor, and / or a PM2.5 sensor. The oxygen sensor is used to detect the oxygen concentration in the environment, the carbon dioxide sensor is used to detect the carbon dioxide concentration in the environment, and the PM2.5 sensor is used to detect the dust concentration in the environment. In some embodiments, the water quality parameter sensor may include a resistivity sensor, and / or a pH sensor, and / or a water substance sensor. The resistivity sensor is used to detect the resistivity / conductivity of the water quality parameter, the pH sensor is used to detect the pH of the water quality parameter, and the water substance sensor is used to detect the concentration of substances in the water quality parameter. The water substance sensor includes a sodium ion detection sensor and / or an oil sensor. The sodium ion sensor is used to detect the sodium ion concentration in the water quality parameter, and the oil sensor is used to detect the oil concentration in the water quality parameter. The water substance sensor may also include a potassium ion sensor, a chloride ion sensor, a carbonate ion sensor, etc. For example, a PM2.5 sensor is installed inside a blood sample analyzer to detect the dust concentration in the environment. A resistivity sensor is installed inside the blood sample analyzer where the cleaning water flows to detect the resistivity or conductivity of the cleaning water. An aquatic substance sensor can be installed inside the blood sample analyzer where the cleaning water flows to detect the concentration of specific substances in the cleaning water; alternatively, the aquatic substance sensor can be installed inside the blood sample analyzer where no cleaning water flows directly. Cleaning water is drawn up using a transport tool and transferred to the sensor's detection location to initiate the detection of the cleaning water; after the detection is completed, the cleaning water from that test is discharged.

[0093] In some embodiments, the environmental parameters include at least one of ambient air pressure, ambient temperature, ambient humidity, water quality parameters, and gas content parameters, which are respectively detected by corresponding sensors.

[0094] Optionally, the processor 140 may be implemented by software, hardware, firmware, or a combination thereof, and may use at least one of the following: circuit, single or multiple application-specific integrated circuits (ASICs), digital signal processors (DSPs), digital signal processing devices (DSPDs), programmable logic devices (PLDs), field-programmable gate arrays (FPGAs), central processing units (CPUs), controllers, microcontrollers, and microprocessors, so that the processor 120 may perform some or all of the steps or any combination of the steps in the various embodiments of this application.

[0095] Optionally, see Figure 1 The blood sample analyzer 100 may include a reagent component 150 for carrying reagents and providing them to the measuring component 110 after aspirating the reagents. In some embodiments, the reagent component 150 may include a reagent carrying component 151 and a reagent dispensing mechanism 152. The reagent carrying component 151 is used to carry reagents. In one embodiment, the reagent carrying component 151 may be a reagent tray, which is arranged in a disc-shaped structure and has multiple positions for carrying reagent containers. The reagent carrying component 151 is rotatable and drives the reagent containers it carries to rotate, for rotating the reagent containers to a specific position, such as the position where the reagent dispensing mechanism 152 aspirates the reagents. The number of reagent carrying components 151 may be one or more. The reagent dispensing mechanism 152 is used to aspirate the reagents and discharge them into a reaction cup to be added with the reagents. In one embodiment, the reagent dispensing mechanism 152 may include a reagent needle, which is driven by a two-dimensional or three-dimensional mechanism to move in two-dimensional or three-dimensional space, so that the reagent needle can move to aspirate the reagents carried by the reagent carrying component 151, move to the reaction cup to be added with the reagents, and discharge the reagents into the reaction cup.

[0096] Optionally, the blood sample analyzer 100 may also include a memory for storing any data received, used, and generated by the blood sample analyzer 100 during project testing, such as operating parameters, test parameters, test results, etc.

[0097] In some embodiments, the memory may be volatile memory or non-volatile memory, or both. Non-volatile memory may be read-only memory (ROM), programmable read-only memory (PROM), erasable programmable read-only memory (EPROM), electrically erasable programmable read-only memory (EEPROM), ferromagnetic random access memory (FRAM), flash memory, magnetic surface memory, optical disc, or compact disc read-only memory (CD-ROM); magnetic surface memory may be disk storage or magnetic tape storage. Volatile memory may be random access memory (RAM), which serves as an external cache. By way of example, but not limitation, many forms of RAM are available, such as Static Random Access Memory (SRAM), Synchronous Static Random Access Memory (SSRAM), Dynamic Random Access Memory (DRAM), Synchronous Dynamic Random Access Memory (SDRAM), Double Data Rate Synchronous Dynamic Random Access Memory (DDRSDRAM), Enhanced Synchronous Dynamic Random Access Memory (ESDRAM), SyncLink Dynamic Random Access Memory (SLDRAM), and Direct Rambus Random Access Memory (DRRAM).The memories described in the embodiments of this application are intended to include these and any other suitable types of memories.

[0098] In some embodiments, the blood sample analyzer 100 may further include:

[0099] I / O interfaces can consist of serial interfaces such as USB, IEEE1394, or RS-232C; parallel interfaces such as SCSI, IDE, or IEEE1284; and analog signal interfaces composed of D / A converters and A / D converters. Input devices such as keyboards, mice, trackballs, click wheels, buttons, touchpads, touchscreens, or other control components can be connected to the I / O interfaces, allowing operators to directly input data.

[0100] In some embodiments, a display with display function, such as an LCD screen, touch screen, or LED display, can be connected to the I / O interface, and the blood sample analyzer can output consultation data to the display for display.

[0101] In some embodiments, the blood sample analyzer 100 may further include a communication module. The communication module may include an interface of any communication protocol. The communication interface communicates with the outside world via a network. The sample analyzer can transmit data with any device connected through the network via the communication interface using a certain communication protocol. It should be understood that the blood sample analyzer according to the embodiments of this application is not limited to a single communication interface. Whether it is an interface of a currently known communication protocol or an interface of a communication protocol developed in the future, it can be used in the blood sample analyzer of the embodiments of this application to realize the function of communicating with the outside world via a network, and no limitation is made herein.

[0102] In some embodiments, the memory, processor, I / O interface, and communication module can communicate via a bus. Of course, besides the bus, the memory, processor, I / O interface, and communication module can also communicate in other ways, such as wirelessly, etc., which are not limited here.

[0103] According to an embodiment of this application, in step S110, environmental parameters measured by a sensor are received.

[0104] Specifically, sensor 130 detects environmental parameters of the environment in which the blood environment analyzer 100 is located in real time and sends the detected environmental parameters to processor 140 for storage. Processor 140 can store the received environmental parameters in chronological order into a memory. Different types of environmental parameters can be stored separately. When the environmental parameters are needed for subsequent calculations, the required environmental parameters can be directly requested from the memory. Environmental parameters may include one or more of the following: air pressure parameters detected by an air pressure sensor, temperature parameters detected by a temperature sensor, humidity parameters detected by a humidity sensor, water quality parameters detected by a water quality parameter sensor, and gas concentration parameters detected by a gas concentration sensor. Gas content parameters may include one or more of the following: oxygen concentration detected by an oxygen sensor, carbon dioxide concentration detected by a carbon dioxide sensor, and dust concentration detected by a PM2.5 sensor. Water quality parameters may include one or more of the following: resistivity / conductivity detected by a resistivity sensor, pH detected by a pH sensor, and substance concentration detected by a substance sensor, including sodium ion concentration, oil concentration, etc.

[0105] In actual testing of blood samples, different tests are affected by different environmental parameters. Even when the environment is stable, the environmental parameters during the test will still have a certain impact on the test results. When the environment is unstable, the test results will deviate more significantly, reducing the accuracy of the test.

[0106] For example, CO2 testing is susceptible to interference from CO2 in the environment. High concentrations of CO2 can affect alkaline reagents such as FUN and Mg, while fluctuations in the CO2 concentration in the environment can cause continuous fluctuations in biochemical test results, affecting the accuracy of the test results.

[0107] For example, dust in the air contains a large amount of mineral dust, metal dust, and organic dust. Some test items are very sensitive to dust. For example, the Fe test is easily affected by Fe in the dust, causing a large deviation in the results; the TBA (total bile acid) test is easily affected by organic matter in the dust, which changes the activity of the reagent and causes a large fluctuation in the results.

[0108] In addition, blood sample analyzers require an external water purifier to provide deionized water for cleaning components such as the sampling needle, stirring rod, and reaction cup. After cleaning, a certain amount of residual water will remain. If the water used by the instrument contains a certain concentration of ions, it will affect the test results when measuring metal ions such as Ca, Mg, P, Fe, and Cu using serum samples. Similarly, if the oil concentration in the water does not meet requirements, it will affect the results of TG (triglycerides) measurements.

[0109] Based on the above considerations, this application finds that the impact of environmental parameters and their changes on test results is not unpredictable. The test results can be corrected based on the environmental parameters and their changes to make the test results returned to the user more accurate, further improve the testing accuracy of the blood analyzer, and provide a good data foundation for subsequent sample anomaly judgment based on the results.

[0110] According to an embodiment of this application, in step S120, the test results are corrected based on environmental parameters to obtain a correction result.

[0111] Optionally, the test results are corrected based on environmental parameters to obtain corrected results, which may include:

[0112] Environmental parameters are smoothed to obtain smoothed environmental parameter data;

[0113] Calculate the deviation of project test results based on smoothed environmental parameter data;

[0114] The correction result is obtained based on the test results and the deviation from the results.

[0115] Due to the inherent limitations of sensor accuracy, the detected environmental parameters may contain errors, generating noisy data. This noisy data will introduce greater bias into the calibration process. Therefore, it is necessary to delete or replace obviously abnormal data in the environmental parameters to smooth the overall data and ensure the accuracy of the test results when correcting them.

[0116] In some embodiments, smoothing environmental parameters to obtain smoothed environmental parameter data may include:

[0117] Abnormal environmental parameters that exceed the preset reasonable range will be deleted, and the average value of the two adjacent environmental parameters will be used to replace the abnormal environmental parameter.

[0118] Specifically, the preset reasonable range refers to the range within which environmental parameters are likely to occur. If an environmental parameter is outside the preset reasonable range, extreme or impossible environments will arise. For example, if the environmental parameter is CO2 concentration, the preset reasonable range for CO2 concentration could be [0, 4000] ppm, because CO2 concentration cannot be negative. If the CO2 concentration in the environmental parameters sent by the sensor to the processor is negative, it indicates that the negative value is clearly abnormal. If the CO2 concentration is higher than 4000 ppm, it will cause personnel to become unconscious, meaning that project testing is impossible in that environment. Environmental parameters that exceed the preset reasonable range are considered abnormal environmental parameters and can be replaced by the average value of adjacent environmental parameters. It should be understood that the preset reasonable range can be set as needed and is not restricted here.

[0119] In some embodiments, smoothing environmental parameters to obtain smoothed environmental parameter data may further include: using one or more of the following methods to smooth environmental parameters: mean filtering, median filtering, moving average, exponential mean average, and Savitzky Golay filter, to obtain smoothed environmental parameter data.

[0120] In some embodiments, smoothed environmental parameter data can be smoothed environmental parameter curves that change over time.

[0121] Before conducting project testing, the blood analyzer needs to be calibrated to further reduce errors during the testing process. The environmental conditions and reagents used during the calibration and testing phases may differ, so deviations arising during each phase need to be corrected separately to improve the accuracy of the calibration results.

[0122] Optionally, the environmental parameters include a first environmental parameter within a first time period and a second environmental parameter within a second time period. Calculating the deviation of the project test results based on smoothed environmental parameter data may include:

[0123] The stability of the test environment during the first time period is determined based on the changes in the first environmental parameters during the first time period, where the first time period includes the project testing period.

[0124] If the testing environment is stable, the result deviation is calculated based on the first environmental parameter and the second environmental parameter of the blood sample analyzer during the second time period, where the second time period includes the calibration period;

[0125] If the testing environment is unstable, the result deviation is calculated based on the test deviation in the first time period and the calibration deviation in the second time period.

[0126] When calculating the deviation of the results, it is necessary to consider not only the environmental parameters during the calibration period or the project test period, but also the changes in environmental parameters in the period prior to the calibration period or the project test period, so as to further ensure the accuracy of the calculation of the deviation of the results, thereby achieving the accuracy of the correction results.

[0127] In some embodiments, determining whether the test environment is stable within a first time period based on changes in a first environmental parameter within a first time period includes:

[0128] Determine whether the change of the first environmental parameter in the first sub-time period of the first time period exceeds the change threshold, wherein the first sub-time period is before the start of the project test;

[0129] If the change does not exceed the change threshold, the test environment is considered stable.

[0130] If the change exceeds the change threshold, the test environment is determined to be unstable.

[0131] Specifically, to determine whether the test environment is stable before the start of the test, the first sub-time period before the start of the test can be selected. The first environmental parameter within the first sub-time period is obtained from the smoothed environmental parameter data. The change of the first environmental parameter within this period is calculated to see if it exceeds the change threshold ΔC. If it does not exceed the change threshold ΔC, it means that the total change of the environmental parameter within the first sub-time period is small, and the test environment is stable. If the change of the first environmental parameter within this period exceeds the change threshold ΔC, it means that the total change of the environmental parameter within the first sub-time period is large, and the test environment is unstable.

[0132] Alternatively, the stability of the environment can be determined based on the first rate of change of the first environmental parameter within the first sub-time period. In some embodiments, if the first rate of change is less than or equal to a rate of change threshold, it indicates that the environmental parameter changes slowly in the first sub-time period and the test environment is stable; if the first rate of change is greater than the rate of change threshold, it indicates that the environmental parameter changes rapidly in the first sub-time period and the test environment is unstable.

[0133] In some embodiments, the first time period may include a first sub-time period prior to project testing and during project testing.

[0134] It should be understood that in the above embodiments, the change threshold and change rate can be set as needed, and no restrictions are imposed here.

[0135] In some embodiments, if the testing environment is stable, the result deviation is calculated based on the first environmental parameter and the second environmental parameter of the blood sample analyzer during the second time period, including:

[0136] The result deviation includes reagent parameter deviation and environmental parameter deviation. The reagent parameter deviation includes the parameter deviation between the reagents used in the first time period and the reagents used in the second time period. The environmental parameter deviation is proportional to the difference between the first environmental parameter and the second environmental parameter.

[0137] Specifically, if the testing environment is stable and no secondary calibration is performed before the project test, the reagents may be changed during the time between calibration and project test. In this case, the result deviation needs to take into account the differences in environmental parameters and reagents, because the reagents used in the first time period and the reagents used in the second time period may come from different batches, and the stability of the reagents after opening will also affect the test results. Therefore, the calculated result deviation comprehensively considers the impact of multiple aspects such as calibration environment, testing environment, and reagent differences on the test, which greatly improves the calculation of deviation and thus obtains more accurate correction results.

[0138] In some embodiments, the second time period may include a second sub-time period prior to calibration and during calibration.

[0139] In some embodiments, if the test environment is stable and the blood sample analyzer is not recalibrated prior to the test, the result deviation E may include:

[0140] E = k1(C1-C2) + ΔE1 + ΔE2, where k1 is the first proportion and k1 is a positive number; C1 is the average value of the first environmental parameter during the project testing period, C2 is the average value of the second environmental parameter during the calibration period, ΔE1 is the batch deviation of the reagent, and ΔE2 is the opening deviation of the reagent.

[0141] Furthermore, ΔE1 and ΔE2 can be preset constants. ΔE1 and ΔE2 can be determined experimentally using the reagents. Alternatively, when very high precision is required, ΔE1 and ΔE2 can also be represented by functions. The functions representing ΔE1 and ΔE2 can be obtained by fitting or analyzing data obtained from relevant experiments on the reagents.

[0142] In some embodiments, if the testing environment is stable, the result deviation is calculated based on the first environmental parameter and the second environmental parameter of the blood sample analyzer during the second time period, including:

[0143] The blood sample analyzer was calibrated a second time before the project testing was conducted.

[0144] The result deviation is proportional to the difference between the first environmental parameter and the third environmental parameter of the blood sample analyzer during the third time period, where the third time period includes the period of secondary calibration.

[0145] Specifically, if the test environment is stable and a second calibration is performed during the project test, and the reagents used during the second calibration and the project test are the same and there is no impact from opening reagent bottles, then the influence of the reagents can be disregarded, and only the deviation caused by changes in environmental parameters needs to be considered.

[0146] In some embodiments, if the testing environment is stable and the blood sample analyzer is calibrated twice before the project test, the result deviation E may include:

[0147] E = k2(C1-C2), where k2 is the second proportion and k2 is a positive number; C1 is the average value of the first environmental parameter during the project testing period, and C2 is the average value of the second environmental parameter during the calibration period.

[0148] It should be noted that, provided the accuracy requirements are met, even without secondary calibration before project testing, the above method of considering only environmental parameter changes can be used to calculate the result deviation, without having to be limited to considering the influence of reagents. This simplifies the calibration process, saves computational resources, and improves calibration efficiency.

[0149] It should be understood that the first ratio k1 and the second ratio k2 mentioned above can be the same or different, and there is no restriction here. The first ratio k1 and the second ratio k2 can also be fixed values ​​that can be obtained through experiments.

[0150] In some embodiments, if the testing environment is unstable, the result deviation is calculated based on the testing deviation over a first time period and the calibration deviation of the blood sample analyzer over a second time period, including the calibration period, including:

[0151] The stability of the calibration environment in the second time period is determined based on the changes of the second environmental parameter in the second sub-time period of the second preset time period, wherein the second sub-time period is before the calibration begins.

[0152] If the calibration environment is stable, the test deviation is calculated based on the first environmental parameter that exceeds the change threshold within the first time period, and the calibration deviation is calculated based on the second environmental parameter and the reference environmental parameter.

[0153] If the calibration environment is unstable, the test deviation is calculated based on the first environmental parameter that exceeds the change threshold in the first time period, and the calibration deviation is calculated based on the second environmental parameter that exceeds the change threshold in the second time period.

[0154] The result deviation includes the difference between the test deviation and the calibration deviation.

[0155] In cases of unstable testing environments, the effects of both the calibration and testing environments can be considered separately to calculate result deviations. This allows for accurate correction of test results under any calibration or testing environment, improving the precision and reliability of the blood sample analyzer.

[0156] In some embodiments, the stability of the calibration environment in the second time period is determined based on the changes in the second environmental parameter within a second sub-time period of the second preset time period. The second sub-time period, prior to the start of calibration, may include:

[0157] If the change in the second environmental parameter does not exceed the change threshold during the second sub-time period, the calibration environment is determined to be stable.

[0158] If the change in the second environmental parameter exceeds the change threshold during the second sub-time period, the test calibration is determined to be unstable.

[0159] Specifically, to determine whether the calibration environment is stable before calibration begins, the second sub-time period before calibration can be selected for this determination. The second environmental parameter within the second sub-time period is obtained from the smoothed environmental parameter data, and the change of the second environmental parameter during this period is calculated to see if it exceeds the change threshold ΔC. If it does not exceed the change threshold ΔC, it indicates that the total change of the environmental parameter during the second sub-time period is small, and the calibration environment is stable. If the change of the second environmental parameter during this period exceeds the change threshold ΔC, it indicates that the total change of the environmental parameter during the second sub-time period is large, and the calibration environment is unstable.

[0160] Similarly, just as with determining the stability of the test environment, the calibration environment can be determined based on the rate of change of the second environmental parameter within the second sub-time period. If the rate of change of the second environmental parameter within the second sub-time period is less than or equal to the rate of change threshold, it indicates that the environmental parameter changes slowly in the second sub-time period, and the calibration environment is stable; if the rate of change is greater than the rate of change threshold, it indicates that the environmental parameter changes rapidly in the second sub-time period, and the calibration environment is unstable.

[0161] In some embodiments, the test deviation is calculated based on a first environmental parameter that exceeds a change threshold within a first time period, including:

[0162] Divide the first time period into n sub-test time periods, and determine whether the change of the first environmental parameter in each sub-test time period exceeds the change threshold, where n is a positive integer;

[0163] Calculate the average value Cm of the first environmental parameter in m sub-test time periods that exceed the change threshold, where m is a positive integer less than n;

[0164] The test deviation is obtained based on the baseline environmental parameter C0, the experimental environmental parameter C, the m average values ​​Cm, and the component functions associated with the average value Cm.

[0165] Since the testing environment is unstable, the test deviation can be calculated based on the first environmental parameter exceeding the change threshold ΔC within the first time period. Specifically, the first time period can be divided into n sub-test time periods according to Δt1, where n is a positive integer; for the sub-test time periods where the change of the first environmental parameter is greater than the change threshold ΔC, these are denoted as time periods m1, m2, ..., and the average values ​​Cm1, Cm2, ... of the environmental parameters within time periods m1, m2, ... are calculated. Then, the test deviation E1 can include:

[0166] E1=[(C m1 -C0) / (C-C0)]*[y(n)-y(n-m1)]+[(C m2 -C0) / (C-C0)]*[y(n-m1)-y(n-m2)]+……;

[0167] Where C0 is the baseline environmental parameter, C is the experimental environmental parameter, and the component function y(i) = E0[1-(T1 / (T1-T2))e -(iΔt1 / T1) +T2 / (T1-T2))e -(iΔt1 / T2) E0 represents the deviation of the baseline result obtained from the baseline environmental parameters, while T1 and T2 are fixed parameters.

[0168] The parameters E0, T1, and T2 can be obtained experimentally. E0 determines the amplitude of the component function, while T1 and T2 determine its shape. When experimenting with a blood analyzer, setting the experimental environment parameter to C yields the parameters E0, T1, and T2. The deviation of the results obtained from experiments or calculations under the baseline environment parameter C0 is the baseline deviation E0.

[0169] In one embodiment, the first time period is divided into 5 equal sub-test time periods, n=5, denoted as sub-test time periods 1, 2, 3, 4, and 5. The changes in the first environmental parameter during the 2nd and 5th sub-test time periods are greater than the change threshold ΔC, and are denoted as time periods m1=2 and m2=5, respectively, with corresponding average values ​​C. m1 (C2), C m2 (C0), then the test deviation E1 can include:

[0170] E1=[(C2-C0) / (C-C0)]*[y(5)-y(3)]+[(C0-C0) / (C-C0)]*[y(3)-y(0)]+……;

[0171] y(5)=E0[1-(T1 / (T1-T2))e -(5Δt1 / T1) +T2 / (T1-T2))e -(5Δt1 / T2) ];

[0172] y(3)=E0[1-(T1 / (T1-T2))e -(3Δt1 / T1) +T2 / (T1-T2))e -(3Δt1 / T2) ];

[0173] y(0)=E0[1-(T1 / (T1-T2))e -(0.Δt1 / T1) +T2 / (T1-T2))e -(0.Δt1 / T2) ]

[0174] =0.

[0175] In some embodiments, the calibration deviation is calculated based on the second environmental parameter and the reference environmental parameter, including:

[0176] The calibration deviation includes reagent parameter deviation and environmental parameter deviation. The reagent parameter deviation includes the parameter deviation between the reagents used in the first time period and the reagents used in the second time period. The environmental parameter deviation is proportional to the difference between the second environmental parameter and the reference environmental parameter.

[0177] If the testing environment is unstable while the calibration environment is stable, the calibration deviation can be calculated based on the second environmental parameter and the reference environmental parameter of the stable calibration environment. Specifically, the calibration deviation E2 = k3(C1-C2) + ΔE1 + ΔE2, where k3 is the third ratio and k3 is a positive number; C1 is the average value of the first environmental parameter during the test period, C2 is the average value of the second environmental parameter during the calibration period, ΔE1 is the batch deviation of the reagent, and ΔE2 is the opening deviation of the reagent.

[0178] Alternatively, while meeting accuracy requirements, the calibration deviation E2 may also include: E2 = k3(C1-C2), where k3 is the third proportion and k3 is a positive number; C1 is the average value of the first environmental parameter during the project testing period, and C2 is the average value of the second environmental parameter during the calibration period.

[0179] It should be understood that the third ratio k3 can be the same as or different from the first ratio k1 / second ratio k2, and no restrictions are imposed here.

[0180] In some embodiments, the calibration deviation is calculated based on a second environmental parameter that exceeds a change threshold within a second time period, including:

[0181] The second time period is divided into p sub-calibration time periods. It is determined whether the change of the second environmental parameter in each sub-calibration time period exceeds the change threshold, where p is a positive integer.

[0182] Calculate the average value Cq of the second environmental parameter within q sub-calibration time periods that exceed the change threshold, where q is a positive integer less than p;

[0183] The calibration deviation is obtained based on the baseline environmental parameter C0, the experimental environmental parameter C, q average values ​​Cq, and the component functions associated with the average value Cq.

[0184] If both the test environment and the calibration environment are unstable, the calibration deviation can be calculated based on the second environmental parameter exceeding a change threshold within the second time period. Specifically, similar to calculating the test deviation under unstable test environment conditions, the second time period can be divided into p sub-calibration time periods by Δt2, where p is a positive integer. For each sub-calibration time period where the change in the second environmental parameter exceeds the change threshold ΔC, these sub-calibration time periods are denoted as time periods q1, q2, ..., and the average value C of the environmental parameter within time periods q1, q2, ... is calculated. q1 C q2 ... Therefore, the calibration deviation E2 can include:

[0185] E2=[(C q1 -C0) / (C-C0)]*[y(p)-y(p-q1)]+[(C q2 -C0) / (C-C0)]*[y(p-q1)-y(n-q2)]+……;

[0186] Where C0 is the baseline environmental parameter, C is the experimental environmental parameter, and the component function y(i) = E0[1-(T1 / (T1-T2))e -(iΔt2 / T1) +T2 / (T1-T2))e -(iΔt2 / T2) E0 represents the deviation of the baseline result obtained from the baseline environmental parameters, while T1 and T2 are fixed parameters.

[0187] In some embodiments, the result deviation includes the difference between the test deviation and the calibration deviation, including: result deviation = calibration deviation - test deviation.

[0188] Optionally, environmental parameters may include water sample results. The test results are then corrected based on these environmental parameters to obtain corrected results, including:

[0189] Obtain the deviation of water sample results obtained from project testing using water samples;

[0190] The deviation of the project test results was obtained based on the deviation of the water sample results.

[0191] The correction result is obtained based on the test results and the deviation from the results.

[0192] Specifically, the deviation E of the water sample results can be obtained by using water samples for project testing. 水Because of E 水 It can be represented as E 水 =A1*D+B1, where D is an intermediate variable of environmental parameters; and the deviation E of the blood sample results obtained from the project testing is... 血 And E 血 It can be represented as E 血 =A2*D+B2, where D is the same intermediate environmental parameter as above. Therefore, according to E... 水 =A1*D+B1 can be used to calculate D, and then the result deviation E can be obtained. 血 =A2*D+B2==A2*((E 水 -B1) / A1)+B2. Where A1, B1, A2, and B2 are experimental parameters, all of which can be obtained experimentally.

[0193] Optionally, the correction results obtained based on the test results and the result deviations include:

[0194] Correction result = Test result - Result deviation.

[0195] Taking the dust concentration detected by the PM2.5 sensor as an example, if the change between the dust concentration during the test period and the dust concentration during the calibration period exceeds a threshold, it is determined that the dust concentration will affect the test results. In this case, the test results are corrected according to the relationship between the result deviation and the dust concentration.

[0196] First, determine the stability of the test environment based on changes in dust concentration during or before the test. If the change in dust concentration during or before the test does not exceed a threshold, the test environment is considered stable. If the change in dust concentration during or before the test exceeds a threshold, the test environment is considered unstable.

[0197] If the testing environment is stable, the deviation in the result is calculated based on the dust concentration during testing and the dust concentration during calibration. Taking Fe testing as an example, the result deviation ΔY of Fe testing is affected by dust concentration. Fe With the change in dust concentration ΔC 粉尘 Between, satisfying ΔY Fe =a*ΔC 粉尘 +b, where:

[0198] ΔY Fe The deviation between the test results and the actual results for the Fe project;

[0199] ΔC 粉尘 =C2-C1, where C2 is the dust concentration during the project testing period and C1 is the dust concentration during the calibration period;

[0200] a represents the slope parameter, and b represents the intercept parameter, which are determined experimentally or theoretically based on ΔY.Fe and ΔC 粉尘 The relationship was calculated.

[0201] Furthermore, if the testing environment is unstable, i.e., the dust concentration continuously changes during the Fe project testing process, the Fe project testing process is divided into n consecutive time periods t1, t2, t3, ..., tn according to the set time interval t, and ΔYn is calculated for each time period. Fe =a*ΔCn 粉尘 +b. Final result deviation ΔY Fe =ΔY1 Fe +ΔY2 Fe +ΔY3 Fe +…+ΔYn Fe =a*(ΔC1) 粉尘 +ΔC2 粉尘 +ΔC3 粉尘 +…+ΔCn 粉尘 )+n*b.

[0202] In some embodiments, regardless of whether the test environment is stable, the test process can be divided into multiple consecutive time periods, the result deviation in each time period can be calculated separately, and the final result deviation can be accumulated to improve the accuracy of calibration.

[0203] Taking resistivity as an example among water quality parameters, if the change in resistivity during the testing period does not exceed the threshold compared to the calibration period, the tested water quality parameter is determined to be normal. If the change in resistivity during the testing period exceeds the threshold compared to the calibration period, the tested water quality parameter is determined to be abnormal. In this case, the test results are corrected based on the relationship between the result deviation and resistivity.

[0204] Specifically, the stability of the test environment is determined by the change in resistivity during or before the test. If the change in resistivity during or before the test does not exceed a threshold, the test environment is considered stable. If the change in resistivity during or before the test exceeds a threshold, the test environment is considered unstable.

[0205] If the testing environment is stable, the deviation of the result is calculated based on the resistivity during measurement and the resistivity during calibration. Continuing with the Fe test as an example, the result deviation ΔY caused by the influence of resistivity on the Fe test is... Fe With resistivity change ΔR 电阻率 Between, satisfying ΔY Fe =a*ΔR 电阻率 +b, where:

[0206] ΔY Fe The deviation between the test results and the actual results for the Fe project;

[0207] ΔR电阻率 =R2-R1, where R2 is the resistivity during the project testing period and R1 is the resistivity during the calibration period;

[0208] a represents the slope parameter, and b represents the intercept parameter, which are determined experimentally or theoretically based on ΔY. Fe and ΔR 电阻率 The relationship was calculated.

[0209] Furthermore, if the test environment is unstable, i.e., the resistivity continuously changes during the Fe test, the Fe test process is divided into n consecutive time periods t1, t2, t3, ..., tn according to a set time interval t, and ΔYn is calculated for each time period. Fe =a*ΔRn 电阻率 +b. Final result deviation ΔY Fe =ΔY1 Fe +ΔY2 Fe +ΔY3 Fe +…+ΔYn Fe =a*(ΔR1) 电阻率 +ΔR2 电阻率 +ΔR3 电阻率 +…+ΔRn 电阻率 )+n*b.

[0210] Na, K, Cl, Li, carbonate ions (CO3) - Water quality parameters such as oil and grease can also be correlated with the results of specific tests to correct the test results. Taking sodium (Na) ions as an example, if the change in sodium ion concentration in the water during the test period does not exceed a threshold compared to the sodium ion concentration during the calibration period, the water quality parameter is considered normal. If the change in sodium ion concentration in the water during the test period exceeds the threshold compared to the sodium ion concentration during the calibration period, the water quality parameter is considered abnormal. In this case, the test results are corrected based on the relationship between the test results and the sodium ion concentration in the water.

[0211] Specifically, the stability of the testing environment can be determined by observing changes in sodium ion concentration during or before the test. If the change in sodium ion concentration during or before the test does not exceed a threshold, the testing environment is considered stable. If the change in sodium ion concentration during or before the test exceeds a threshold, the testing environment is considered unstable.

[0212] If the testing environment is stable, the deviation in the result is calculated based on the sodium ion concentration during testing and the sodium ion concentration during calibration. Taking sodium (Na) detection as an example, the deviation ΔY in the Na result is caused by the influence of sodium ion concentration in the water. Na Changes in sodium ion concentration in water ΔI Na Between, satisfying ΔY Na =a*ΔINa +b, where:

[0213] ΔY Na The deviation between the test results and the actual results for the Na project;

[0214] ΔI Na =I2-I1, where I2 is the sodium ion concentration in the water during the project testing period, and I1 is the sodium ion concentration in the water during the calibration period;

[0215] a represents the slope parameter, and b represents the intercept parameter, which are determined experimentally or theoretically based on ΔY. Na and ΔI Na The relationship was calculated.

[0216] Furthermore, if the testing environment is unstable, i.e., Na continuously changes during the Na project testing process, the Na project testing process is divided into n consecutive time periods t1, t2, t3, ..., tn according to the set time interval t, and ΔYn is calculated for each time period. Na =a*ΔIn Na +b. Final result deviation ΔY Na =ΔY1 Na +ΔY2 Na +ΔY3 Na +…+ΔYn Na =a*(ΔI1) Na +ΔI2 Na +ΔI3 Na +…+ΔIn Na )+n*b.

[0217] Optionally, the blood sample analyzer also includes:

[0218] Display device for displaying test results and / or correction results.

[0219] Optionally, the processor is also used for:

[0220] The control display device shows the test results and prompts the operator whether to display the correction results.

[0221] Specifically, the blood sample analyzer can present test results and / or correction results to the operator. In some embodiments, only the test results may be presented to the operator, and the operator may be prompted on the display device that correction results also exist, such as by lighting up the icon corresponding to "correction results" to indicate that correction results still exist (when the icon corresponding to "correction results" is gray, it indicates that there are no correction results), or by popping up a dialog box indicating that correction results still exist and asking the operator whether to display the correction results. The operator can further restrict the correction results by triggering the corresponding button, including displaying the test results and correction results simultaneously.

[0222] Optionally, the processor is also used for:

[0223] Determine whether the calibration result is within the preset alarm value range;

[0224] If the correction result is not within the preset alarm value range, then the sample is determined to be abnormal;

[0225] An alarm will be triggered when an abnormality occurs in the sample.

[0226] In normal samples, the content of certain substances is generally within the normal range. When the test results of a substance in a sample exceed the normal range, it indicates an abnormality in the sample, requiring an alarm to alert the operator. Compared to traditional methods where the environment can significantly deviate from the test results and prevent sample abnormality alarms, the blood analyzer according to this embodiment corrects the test results through environmental parameters, obtaining more accurate test results and enabling timely and effective alarms, thus improving the accuracy and reliability of substance detection.

[0227] In practical testing applications, some tests require a specific gas (such as oxygen) to participate in the chemical reactions within a solution system containing both samples and reagents. The total amount of gas B in the solution system is related to the partial pressure of gas B in the air surrounding the blood analyzer. This means that in high-altitude, low-pressure environments, the dissolved amount of gas B in the solution system may be insufficient. This significantly reduces the upper limit of the linear range that can be detected for these tests, resulting in high actual concentrations but only the upper limit of the linear range being detected. Using the preset alarm range under normal conditions will reduce the sensitivity of the alarm mechanism, leading to missed detections of abnormal samples and greatly reducing the reliability of the blood sample analyzer. For example, the Glu-GOD (glucose oxidase method) test involves the following reaction steps:

[0228]

[0229]

[0230] The first step of this test requires sufficient oxygen in the solution system to participate in the reaction and generate hydrogen peroxide, which is then used for the subsequent colorimetric reaction. Preliminary calculations indicate that in low-altitude plains, the dissolved oxygen content in the system is approximately 21.412 mmol / L. Considering the continuous dissolution of oxygen into the reaction system during the reaction, the measured upper limit of linearity for this test is approximately 26 mmol / L. However, at high altitudes, the oxygen content in the system decreases as the partial pressure of oxygen in the environment decreases. At an altitude of approximately 4000m, the measured upper limit of linearity for this test drops to 19-22 mmol / L. This significantly increases the risk of high-value samples being measured as low-value samples at high altitudes.

[0231] Based on the above considerations, the processor in the blood sample analyzer according to an embodiment of the present invention can also perform the following steps:

[0232] Step S201: Determine the preset alarm value range based on environmental parameters;

[0233] Step S202: Determine whether the test result is within the preset alarm value range to determine whether the blood sample is abnormal.

[0234] Among them, the alarm value range is determined according to the environmental parameters of the environment in which the blood sample analyzer is located. When the test results are affected by the environment but the actual test results cannot be accurately corrected, the alarm value range is changed accordingly based on the environmental parameters. This allows for different alarm value ranges in different environments, thus solving the problem of missing abnormal samples and improving the reliability of the blood sample analyzer and the sensitivity of the alarm mechanism.

[0235] In some embodiments, the blood sample analyzer can determine the preset alarm value range for each test item based on environmental parameters during tests such as CREA-S, UA, GLU-G, TC, TG, LDL-C, HDL-C, HbA1c, and Sd LDL-C.

[0236] Optionally, a preset alarm value range is determined based on environmental parameters, including:

[0237] The content of the target item in the mixed liquid is obtained based on the unit volume content of the target item under environmental parameters and the total volume of the blood sample and reagent mixture.

[0238] The upper limit of the preset range is obtained based on the content of the target item in the mixed liquid and the volume of the blood sample;

[0239] The preset alarm value range is determined based on the upper limit value.

[0240] The gas concentration sensor detects the gas concentration in the environment and sends it to the processor. After receiving the gas concentration, the processor combines it with other environmental parameters such as the temperature of the reagent pan to obtain the dissolved gas content in the solution system, and then calculates the upper limit of the concentration that the relevant items can achieve under the dissolved gas content.

[0241] In some embodiments, during testing of a specific project, the oxygen concentration in the environment can be detected by an oxygen sensor and sent to a processor. The processor calculates the dissolved oxygen content in the solution system based on this oxygen concentration and information such as the reagent tray temperature, and then deduces the upper limit of the dissolved oxygen concentration achievable by the specific project at that concentration. Specifically, for example, taking the Glu-G project, the dissolved oxygen in the influent is related to the partial pressure of oxygen in the air and temperature. In a first environment (e.g., 35 degrees Celsius, 100 kPa), the dissolved oxygen content in pure water is approximately 7 mg / L, or about 0.219 mmol / L; the sample volume for the Glu-G project is 2 mL, and the total reaction solution volume is 200 mL; therefore, in an environment of 35 degrees Celsius, 100 kPa:

[0242] The oxygen concentration in the solution system is approximately 0.219 mmol / L;

[0243] Total oxygen content: 0.219 mmol / L * 202 ml = 0.044 mmol;

[0244] The highest measurable glucose concentration is 0.044 mmol / 2 ml = 22 mmol / L;

[0245] Therefore, under the first environmental conditions, the upper limit of the linear range of measurable Glu-G in the solution system is approximately 22 mmol / L.

[0246] Under a second environment (e.g., 35 degrees Celsius, 50 kPa), the dissolved oxygen concentration in the solution system will drop to 0.110 mmol / L according to calculations. At this time, the linear upper limit of measurable Glu-G in the system is calculated to be approximately 11 mmol / L.

[0247] If the preset alarm value range A for the Glu-G test in the first environment is greater than or equal to 15 mmol / L, a traditional blood analyzer, still using the preset alarm value range A in the second environment, will fail to trigger an alarm for any blood sample. This is because the linear upper limit of Glu-G is lower than the preset alarm value range A. For example, the linear upper limit of Glu-G is approximately 11 mmol / L, which is unlikely to be within the preset alarm value range A, thus preventing an alarm from occurring and potentially causing the alarm mechanism to fail. However, the blood sample analyzer in this embodiment can flexibly adjust the preset alarm value range based on the linear upper limit calculated in the second environment. For example, it can be adjusted to the preset alarm value range B, which is greater than or equal to 7 mmol / L. This avoids missing abnormal samples and further ensures the accuracy of the test results of the blood sample analyzer in any environment, improving reliability.

[0248] According to an embodiment of the present invention, a blood sample analyzer is also provided, comprising:

[0249] The measuring component is used to perform tests on the blood sample to be tested in order to obtain test results;

[0250] The sample component is used to hold the blood sample to be tested and to provide the blood sample to the measuring component after it is drawn up;

[0251] Sensors are used to collect environmental parameters of the environment in which the blood sample analyzer is located;

[0252] A processor, when configured to execute one or more programs, performs the following steps:

[0253] Step S301: Receive environmental parameters from the sensor;

[0254] Step S302: Determine whether the test result is within the preset alarm value range to determine whether the blood sample is abnormal. The test result is based on the environmental parameter correction test result or the preset alarm value range is determined.

[0255] Therefore, the blood sample analyzer according to the embodiments of this application can improve the accuracy of the test by detecting the environmental parameters of its environment and correcting the test results based on the environmental parameters; or it can improve the reliability of the test by determining the alarm value range of the test based on the environmental parameters.

[0256] Those skilled in the art will recognize that the units and algorithm steps of the various examples described in conjunction with the embodiments disclosed herein can be implemented in electronic hardware, or a combination of computer software and electronic hardware. Whether these functions are implemented in hardware or software depends on the specific application and design constraints of the technical solution. Those skilled in the art can use different methods to implement the described functions for each specific application, but such implementation should not be considered beyond the scope of this application.

[0257] In the several embodiments provided in this application, it should be understood that the disclosed devices and methods can be implemented in other ways. For example, the device embodiments described above are merely illustrative. For instance, the division of units is only a logical functional division, and in actual implementation, there may be other division methods. For example, multiple units or components may be combined or integrated into another device, or some features may be ignored or not executed.

[0258] Numerous specific details are set forth in the specification provided herein. However, it will be understood that embodiments of this application may be practiced without these specific details. In some instances, well-known methods, structures, and techniques have not been shown in detail so as not to obscure the understanding of this specification.

[0259] Similarly, it should be understood that, in order to simplify this application and aid in understanding one or more aspects of the application, various features of this application may sometimes be grouped together in a single embodiment, figure, or description thereof in the description of exemplary embodiments of this application. However, this approach should not be construed as reflecting an intention that the claimed application requires more features than are expressly recited in each claim. Rather, as reflected in the corresponding claims, the point of application is that the corresponding technical problem can be solved with fewer features than all of a single disclosed embodiment. Therefore, the claims following the detailed description are hereby expressly incorporated into that detailed description, wherein each claim itself is a separate embodiment of this application.

[0260] Those skilled in the art will understand that, apart from the mutual exclusion of features, all features disclosed in this specification (including the accompanying claims, abstract, and drawings) and all processes or units of any method or apparatus so disclosed can be combined in any combination. Unless otherwise expressly stated, each feature disclosed in this specification (including the accompanying claims, abstract, and drawings) may be replaced by an alternative feature that serves the same, equivalent, or similar purpose.

[0261] Furthermore, those skilled in the art will understand that although some embodiments described herein include certain features but not others included in other embodiments, combinations of features from different embodiments are intended to be within the scope of this application and form different embodiments. For example, in the claims, any one of the claimed embodiments can be used in any combination.

[0262] It should be noted that the above embodiments are illustrative of this application and not restrictive, and that those skilled in the art can devise alternative embodiments without departing from the scope of the appended claims. In the claims, any reference signs placed between parentheses should not be construed as limiting the claims. The word "comprising" does not exclude the presence of elements or steps not listed in the claims. The word "a" or "an" preceding an element does not exclude the presence of a plurality of such elements. This application can be implemented by means of hardware comprising several different elements and by means of a suitably programmed computer. In the unit claims enumerating several means, several of these means may be embodied by the same item of hardware. The use of the words first, second, and third, etc., does not indicate any order. These words can be interpreted as names.

[0263] The above description is merely a specific embodiment or illustration of the embodiments of this application. The scope of protection of this application is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the scope of the technology disclosed in this application should be included within the scope of protection of this application. The scope of protection of this application shall be determined by the scope of the claims.

Claims

1. A blood sample analyzer, characterized in that, include: The measuring component is used to perform tests on the blood sample to be tested in order to obtain test results; A sample component is used to hold the blood sample to be tested and to provide the blood sample to the measuring component after aspirating it. Sensors are used to collect environmental parameters of the environment in which the blood sample analyzer is located; A processor, configured to perform the following steps when executing one or more programs: Receive the environmental parameters measured by the sensor; The test results are corrected based on the environmental parameters to obtain the correction results; The process of correcting the test results based on the environmental parameters to obtain the correction results includes: The stability of the test environment during the first time period is determined based on the changes in the first environmental parameters during the first time period, wherein the first time period includes the project test period; If the test environment is stable, the deviation of the result is calculated based on the first environmental parameter and the second environmental parameter of the blood sample analyzer during a second time period, wherein the second time period includes the calibration period; If the test environment is unstable, the result deviation is calculated based on the test deviation in the first time period and the calibration deviation in the second time period.

2. The blood sample analyzer according to claim 1, characterized in that, The test results are corrected based on the environmental parameters to obtain the correction results, including: The environmental parameters are smoothed to obtain smoothed environmental parameter data; The deviation of the test results for the project is calculated based on the smoothed environmental parameter data. The correction result is obtained based on the test results and the deviation from the results.

3. The blood sample analyzer according to claim 1, characterized in that, If the test environment is stable, the result deviation is calculated based on the first environmental parameter and the second environmental parameter of the blood sample analyzer during the second time period, including: The result deviation includes reagent parameter deviation and environmental parameter deviation. The reagent parameter deviation includes the parameter deviation between the reagents used in the first time period and the reagents used in the second time period. The environmental parameter deviation is proportional to the difference between the first environmental parameter and the second environmental parameter.

4. The blood sample analyzer according to claim 1, characterized in that, If the test environment is stable, the result deviation is calculated based on the first environmental parameter and the second environmental parameter of the blood sample analyzer during the second time period, including: The blood sample analyzer was calibrated a second time before the aforementioned test was conducted. The result deviation is proportional to the difference between the first environmental parameter and the third environmental parameter of the blood sample analyzer during the third time period, wherein the third time period includes the secondary calibration period.

5. The blood sample analyzer according to claim 1, characterized in that, Determining whether the test environment is stable within the first time period based on changes in the first environmental parameter within the first time period includes: Determine whether the change of the first environmental parameter in the first sub-time period of the first time period exceeds the change threshold, wherein the first sub-time period is before the start of the project test; If the change does not exceed the change threshold, then the test environment is determined to be stable; If the change exceeds the change threshold, the test environment is determined to be unstable.

6. The blood sample analyzer according to claim 5, characterized in that, If the testing environment is unstable, the result deviation is calculated based on the testing deviation of the first time period and the calibration deviation of the blood sample analyzer during the second time period, including the calibration period, including: The stability of the calibration environment in the second time period is determined based on the changes of the second environmental parameter in the second sub-time period of the second preset time period, wherein the second sub-time period is before the start of the calibration. If the calibration environment is stable, the test deviation is calculated based on the first environmental parameter that exceeds the change threshold during the first time period, and the calibration deviation is calculated based on the second environmental parameter and the reference environmental parameter. If the calibration environment is unstable, the test deviation is calculated based on a first environmental parameter that exceeds the change threshold during the first time period, and the calibration deviation is calculated based on a second environmental parameter that exceeds the change threshold during the second time period. The result deviation includes the difference between the test deviation and the calibration deviation.

7. The blood sample analyzer according to claim 6, characterized in that, The test deviation is calculated based on a first environmental parameter that exceeds the change threshold within the first time period, including: Divide the first time period into n sub-test time periods, and determine whether the change of the first environmental parameter in each sub-test time period exceeds the change threshold, where n is a positive integer; Calculate the average value Cm of the first environmental parameter within m sub-test time periods that exceed the change threshold, where m is a positive integer less than n; The test deviation is obtained based on the baseline environmental parameter C0, the experimental environmental parameter C, the m average values ​​Cm, and the component functions associated with the average values ​​Cm.

8. The blood sample analyzer according to claim 6, characterized in that, The calibration deviation is calculated based on the second environmental parameter and the reference environmental parameter, including: The calibration deviation includes reagent parameter deviation and environmental parameter deviation. The reagent parameter deviation includes the parameter deviation between the reagents used in the first time period and the reagents used in the second time period. The environmental parameter deviation is proportional to the difference between the second environmental parameter and the reference environmental parameter.

9. The blood sample analyzer according to claim 6, characterized in that, The calibration deviation is calculated based on a second environmental parameter that exceeds the change threshold during the second time period, including: The second time period is divided into p sub-calibration time periods, and it is determined whether the change of the second environmental parameter in each sub-calibration time period exceeds the change threshold, where p is a positive integer; Calculate the average value Cq of the second environmental parameter within q sub-calibration time periods that exceed the change threshold, where q is a positive integer less than p; The calibration deviation is obtained based on the baseline environmental parameter C0, the experimental environmental parameter C, q average values ​​Cq, and the component functions associated with the average values ​​Cq.

10. The blood sample analyzer according to claim 1, characterized in that, The environmental parameters include water sample results. Based on the environmental parameters, the test results are corrected to obtain corrected results, including: Obtain the deviation of water sample results obtained by testing the project using water samples; The test result deviation of the project is obtained based on the deviation of the water sample results; The correction result is obtained based on the test results and the deviation from the results.

11. The blood sample analyzer according to claim 1, characterized in that, The blood sample analyzer also includes: A display device is used to display the test results and / or the correction results.

12. The blood sample analyzer according to claim 11, characterized in that, The processor is also used for: The display device is controlled to display the test results and prompts the operator whether to display the calibration results.

13. The blood sample analyzer according to claim 1, characterized in that, The processor is also used for: Determine whether the correction result is within the preset alarm value range; If the correction result is not within the preset alarm value range, then the sample is determined to be abnormal; An alarm will be triggered when the sample is abnormal.

14. The blood sample analyzer according to any one of claims 1-13, characterized in that, The environmental parameters include at least one of the following: ambient air pressure, ambient temperature, ambient humidity, water quality parameters, and gas content parameters.

15. The blood sample analyzer according to claim 14, characterized in that, The water quality parameters include at least one of resistivity, conductivity, pH, and concentration of substances in the water.

16. The blood sample analyzer according to claim 14, characterized in that, The gas content parameters include at least one of oxygen concentration, carbon dioxide concentration, and dust concentration.

Images