Eye Acupoint Patches

Abstract

The present invention discloses an eye periocular acupuncture patch, which includes an overlapping and bonded auxiliary layer and a conductive layer. The auxiliary layer and the conductive layer are arranged with a plurality of mutually interpenetrating air holes. The outer surface of the conductive layer is coated with a medical pressure-sensitive adhesive. The medical pressure-sensitive adhesive is provided with a plurality of linear acupuncture point stimulators. Each acupuncture point stimulator is composed of a plurality of resin filaments and a conductive filament. The conductive filament is composed of a layer of polyester fiber wrapped around a plurality of bundles of polyacrylonitrile fiber, and the periphery of each polyester fiber and polyacrylonitrile fiber is coated with a conductive polymer. Applying the eye periocular acupuncture patch of the present invention to the acupuncture points around the eyes for external force stimulation can relieve eye discomfort symptoms such as visual fatigue, dry eyes, eye astringency, myopia, eye soreness and pain, and tearing in the wind caused by excessive eye use. It is non-invasive and safe.

Description

Technical Field

[0001] The present invention relates to the technical field of acupoint patches, and more particularly to an eye periocular acupoint patch. Background Art

[0002] Bioelectricity is a universal phenomenon in all living organisms; all living cells generate an electrical current. The Italian biologist L.A. Galvani (1737-1798) first discovered bioelectricity. Since its discovery in the 2000s, it has been utilized in various fields, leading to the development of electrocardiograms, electromyograms, and electroencephalograms, providing crucial diagnostic tools for doctors. Bioelectricity originates from the function of cells. The cell membrane separates cells from the external environment. The membrane is primarily composed of potassium ions (K+) and some large negative ion groups (A-), while the outer membrane is primarily composed of sodium ions (Na+) and chloride ions (Cl-). In the resting state, when unstimulated, the cell membrane is negatively charged on the inside and positively charged on the outside. The inner membrane potential is approximately -90 to 70 mV, which is called the resting potential. When cells are stimulated by external stimuli and reach a certain threshold, they become excited, which eventually causes a change in the potential inside and outside the membrane. At this time, the potential inside the cell can suddenly change from a negative potential to a positive potential (about 20-30mV). The potential at this time is called an action potential, also known as bioelectricity. When a pathological change occurs in an organism, the electrical phenomena of the organism will deviate from the normal track, and the bioelectricity between cells and between organs will become unbalanced step by step, thereby causing pathological changes in the corresponding tissues. Take dry eye as an example: more than 80% of dry eyes are caused by lipid abnormalities. The main cause of lipid-dysfunctional dry eyes is the dysfunction of the patient's meibomian glands. Meibomian gland atrophy and blockage are both causes of dysfunction. After the meibomian glands atrophy, the bioelectric conduction of cells is disordered and the cell activity is reduced.

[0003] Existing eye acupoint patches are usually non-woven fabrics soaked with Chinese medicines such as chrysanthemum, cassia seed, pearl powder, borneol, and selfheal. When used, they need to be applied to the eyes and then closed to absorb the medicinal properties. The drug absorption is slow and the effect is poor. In addition, the eyes are covered during use, which is inconvenient for daily use. Summary of the Invention

[0004] An object of the present invention is to solve at least the above problems and to provide at least the advantages which will be described hereinafter.

[0005] Another object of the present invention is to provide an eye periocular acupoint patch, which only needs to be applied to the eye periocular acupoints, is easy to use, can effectively relieve eye discomfort symptoms without the need for medication, and is non-invasive and safe.

[0006] In order to achieve these purposes and other advantages according to the present invention, there is provided an eye periocular acupuncture patch, comprising an overlapping and bonded auxiliary layer and a conductive layer, wherein the auxiliary layer and the conductive layer are provided with a plurality of mutually interpenetrating air holes, the outer surface of the conductive layer is coated with a medical pressure-sensitive adhesive, and a plurality of linear acupuncture point stimulators are arranged on the medical pressure-sensitive adhesive, each acupuncture point stimulator is composed of a plurality of resin filaments and conductive filaments, the conductive filaments are composed of a layer of polyester fiber wrapped around a plurality of bundles of polyacrylonitrile fibers, and the periphery of each polyester fiber and polyacrylonitrile fiber is coated with a conductive polymer.

[0007] Preferably, the method for preparing polyacrylonitrile fiber coated with a conductive polymer mainly comprises the following steps:

[0008] Step 1: dissolving polyacrylonitrile in N,N-dimethylformamide solvent to prepare a polyacrylonitrile solution with a mass fraction of 8 to 20%;

[0009] Step 2: dissolving polyaniline doped with camphorsulfonic acid in N,N-dimethylformamide solvent to prepare a polyaniline composite solution with a mass fraction of 8-20%, wherein the molar ratio of camphorsulfonic acid to polyaniline is (0.01-0.2):1;

[0010] Step 3: Inject the polyacrylonitrile solution prepared in step 1 and the polyaniline composite solution prepared in step 2 into the two solution channels of the coaxial electrospinning equipment respectively, adjust the electrospinning parameters, and after electrospinning, use a roller-assisted dynamic water bath to collect the polyacrylonitrile fibers coated with a conductive polymer.

[0011] Preferably, the method for preparing the polyester fiber coated with the conductive polymer mainly comprises the following steps:

[0012] Step a, dissolving polyethylene terephthalate in a mixed solvent of trifluoroacetic acid and dichloromethane in a volume ratio of (2-4):1 to prepare a polyester solution with a mass fraction of 8-20%;

[0013] Step b, dissolving polyaniline doped with camphorsulfonic acid in N,N-dimethylformamide solvent to prepare a polyaniline composite solution with a mass fraction of 8-20%, wherein the molar ratio of the camphorsulfonic acid to the polyaniline is (0.01-0.2):1;

[0014] Step c: injecting the polyester solution prepared in step a and the polyaniline composite solution prepared in step b into two solution channels of a coaxial electrospinning device respectively, and after electrospinning, collecting them in a drum-assisted dynamic water bath to obtain polyester fibers coated with a conductive polymer.

[0015] Preferably, each acupoint stimulating body is arranged in parallel with a plurality of air holes located in the same row.

[0016] Preferably, each acupoint stimulating body consists of one conductive wire and two resin wires.

[0017] Preferably, the two resin filaments of each acupoint stimulating body are symmetrically arranged side by side on both sides of the conductive wire.

[0018] Preferably, the auxiliary layer is a medical non-woven fabric, and the conductive layer is a conductive foil.

[0019] Preferably, the resin filaments are polyamide fibers.

[0020] The present invention also provides an application of an eye periocular acupoint patch in the preparation of a patch for relieving visual fatigue and treating dry eye.

[0021] The present invention has at least the following beneficial effects:

[0022] First, the eye periocular acupuncture patch of the present invention uses an acupuncture point stimulator and a conductive layer with far-infrared effects. The far-infrared normal incidence rate is 77%, and the radiation wavelength covers the peak matching wavelength of the human body surface. It can resonate small molecules between tissues, thereby activating cells and promoting blood circulation. At the same time, it nourishes the lacrimal glands and meibomian glands, promotes increased tear secretion and prolonged tear film breakup time, and relieves dry eye syndrome.

[0023] Second, the present invention generates continuous pressure through multiple acupoint stimulators, which drives the muscles around the eyes to move as the eyeballs move and blink, dredges the meridians around the eyes, promotes smooth blood flow around the eyes, and relieves symptoms such as dry eyes, foreign body sensation, and eye fatigue;

[0024] Third, the present invention utilizes conductive layers and conductive filaments as the conductive structure to normalize disordered and ineffectively conducted myoelectricity, effectively restoring muscle current at the injured site.

[0025] Fourth, the present invention can dredge the meridians and blood vessels around the eyes, enhance the activity of optic nerve cells, increase the oxygen supply to the blood vessels around the eyes and the retina choroid, protect eyesight, stimulate acupuncture points, dredge the meridians, promote the flow of qi and blood and blood circulation in the eyes, make the meridians painless, and restore the normal physiological function of the eyes.

[0026] Other advantages, objectives and features of the present invention will be reflected in part from the following description and will be understood by those skilled in the art through study and practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 This is a front structural diagram of a technical solution of the present invention;

[0028] Figure 2 This is a schematic diagram of the back structure of a technical solution of the present invention;

[0029] Figure 3 It is a structural schematic diagram of another technical solution of the present invention;

[0030] Figure 4 It is a structural schematic diagram of another technical solution of the present invention;

[0031] Figure 5 is the infrared radiation energy spectrum;

[0032] Among them, 100 is the auxiliary layer, 200 is the conductive layer, 300 is the air hole, 400 is the acupoint stimulation body, 401 is the resin wire, and 402 is the conductive wire. DETAILED DESCRIPTION

[0033] The present invention will be described in further detail below in conjunction with the accompanying drawings so that those skilled in the art can implement the invention with reference to the description.

[0034] It should be understood that terms such as “having”, “including” and “comprising” used herein do not preclude the existence or addition of one or more other elements or combinations thereof.

[0035] It should be noted that the experimental methods described in the following embodiments are conventional methods unless otherwise specified, and the reagents and materials are commercially available unless otherwise specified. In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "set" should be understood in a broad sense, for example, they can be fixedly connected or set, or detachably connected or set, or integrally connected or set. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to the specific circumstances. The orientations or positional relationships indicated by the terms "transverse", "longitudinal", "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc. are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description. They do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention.

[0036] like Figures 1 to 4 As shown, the present invention provides an eye periocular acupuncture patch, comprising an auxiliary layer 100 and a conductive layer 200 that are overlapped and bonded together, wherein the auxiliary layer 100 and the conductive layer 200 are provided with a plurality of mutually interpenetrating air holes 300, the outer surface of the conductive layer 200 is coated with a medical pressure-sensitive adhesive, and a plurality of linear acupuncture point stimulating bodies 400 are arranged on the medical pressure-sensitive adhesive, each acupuncture point stimulating body 400 is composed of a plurality of resin filaments 401 and a conductive filament 402, wherein the conductive filament 402 is composed of a layer of polyester fiber wrapped around a plurality of bundles of polyacrylonitrile fiber, and the periphery of each polyester fiber and polyacrylonitrile fiber is coated with a conductive polymer.

[0037] In this technical solution, the auxiliary layer 100 is made of spunlace non-woven fabric, which has a soft feel, good air permeability and high moisture absorption. The conductive layer 200 is made of metal conductive foil. The auxiliary layer 100 and the conductive layer 200 are superimposed and bonded together. A plurality of through-holes 300 are provided on the auxiliary layer 100 and the conductive layer 200. The plurality of holes 300 are arranged in parallel in multiple rows, so that the eye acupoint patch does not hinder skin breathing, increases wearing comfort, and prevents allergies. The surface of the conductive layer 200 is coated with pressure-sensitive adhesive, and a plurality of acupoint stimulators 400 are also adhered to the surface of the conductive layer 200. The plurality of acupoint stimulators 400 are arranged in parallel, and any acupoint stimulator 400 is parallel to the center line of any row of holes 300. The holes 300 can be circular holes or square holes. The pressure-sensitive adhesive is configured to adhere to the skin while ensuring that the acupoint stimulation body 400 is placed stably. The conductive wire 402 creates an environment for generating bioelectric current, allowing the bioelectric current to flow more smoothly. The resin wire 401 plays a supporting role, used to share the supporting force of the conductive wire 402, and the resin wire 401 is symmetrically arranged on both sides of the conductive wire 402 to balance the current. The conductive wire 402 and the conductive layer 200 form a conductive structure and reflect infrared rays at the same time. When using the eye acupoint patch described in this technical solution, select acupoints such as Tongziliao, Sibai, Jingming, Yuyao, and temples for application. Among them, Tongziliao is the first acupoint on the head and face of the Foot Shaoyang Gallbladder Meridian. According to traditional Chinese medicine theory, "the excess qi of the liver is discharged into the bright gallbladder and gathered into essence." It is mainly used to treat: red eyes, eye pain, photophobia, tears in the wind, farsightedness, cataracts, and eye opacity. Pressing this point can promote blood circulation in the eyes, treat common eye acupoints and remove wrinkles at the corners of the eyes; Sibai is an acupoint on the Foot Yangming Stomach Meridian. Indications: Red and painful eyes, eyelid twitching, facial paralysis, headache and dizziness, facial nerve paralysis, hemifacial spasm, keratitis, conjunctival itching, and corneal leukoplakia. Massaging this point can improve eye function and relieve eye diseases such as eye fatigue, myopia, and color blindness. Jingming Point is the first point on the Foot-Taiyang Bladder Meridian, located in the depression slightly above the inner corner of the eye. It is mainly used to treat red, swollen, and painful eyes, tearing, blurred vision, glare, myopia, night blindness, color blindness, tearing in the wind, conjunctivitis, iris inflammation, eye fatigue, and myopia. It is a commonly used acupuncture point for treating eye diseases, and massaging this point can significantly relieve eye fatigue. Yuyao Point is an extra meridian point with the effects of calming the mind, improving eyesight, clearing away wind and heat, and dredging the meridians to relieve pain. It is mainly used to treat red, swollen, and painful eyes, ptosis, myopia, and acute conjunctivitis. Massaging this point can relieve fatigue and headaches, relieve dry eyes, and eliminate eye edema and dark circles. The temple is an extra meridian point, which is mainly used to treat headaches, migraines, red and swollen eyes, eye fatigue, etc. Massaging this point can relieve eye fatigue.

[0038] In another technical solution, a method for preparing polyacrylonitrile fiber coated with a conductive polymer mainly includes the following steps:

[0039] Step 1: dissolving polyacrylonitrile in N,N-dimethylformamide solvent to prepare a polyacrylonitrile solution with a mass fraction of 8 to 20%;

[0040] Step 2: dissolving polyaniline doped with camphorsulfonic acid in N,N-dimethylformamide solvent to prepare a polyaniline composite solution with a mass fraction of 8-20%, wherein the molar ratio of camphorsulfonic acid to polyaniline is (0.01-0.2):1;

[0041] Step 3: Inject the polyacrylonitrile solution prepared in step 1 and the polyaniline composite solution prepared in step 2 into the two solution channels of the coaxial electrospinning equipment respectively, adjust the electrospinning parameters, and after electrospinning, use a roller-assisted dynamic water bath to collect the polyacrylonitrile fibers coated with a conductive polymer.

[0042] In another technical solution, a method for preparing a polyester fiber coated with a conductive polymer mainly comprises the following steps:

[0043] Step a, dissolving polyethylene terephthalate in a mixed solvent of trifluoroacetic acid and dichloromethane in a volume ratio of (2-4):1 to prepare a polyester solution with a mass fraction of 8-20%;

[0044] Step b, dissolving polyaniline doped with camphorsulfonic acid in N,N-dimethylformamide solvent to prepare a polyaniline composite solution with a mass fraction of 8-20%, wherein the molar ratio of the camphorsulfonic acid to the polyaniline is (0.01-0.2):1;

[0045] Step c: injecting the polyester solution prepared in step a and the polyaniline composite solution prepared in step b into two solution channels of a coaxial electrospinning device respectively, and after electrospinning, collecting them in a drum-assisted dynamic water bath to obtain polyester fibers coated with a conductive polymer.

[0046] In another technical solution, Figures 1 to 4 As shown, each acupoint stimulation body 400 is arranged in parallel with a plurality of air holes 300 located in the same row.

[0047] In another technical solution, Figures 1 to 4 As shown, each acupoint stimulating body 400 is composed of two resin wires 401 and one conductive wire 402.

[0048] In another technical solution, Figures 1 to 4 As shown, the two resin filaments 401 of each acupoint stimulation body 400 are symmetrically arranged side by side on both sides of the conductive filament 402.

[0049] In another technical solution, the auxiliary layer 100 is a medical non-woven fabric, and the conductive layer 200 is a conductive foil.

[0050] In another technical solution, the resin filament 401 is polyamide fiber.

[0051] The present invention also provides an application of an eye periocular acupoint patch in the preparation of a patch for relieving visual fatigue and treating dry eye.

[0052] <Example 1>

[0053] The eye periocular acupoint patch includes an overlapping and bonded auxiliary layer and a conductive layer. The auxiliary layer and the conductive layer are arranged with multiple mutually penetrating air holes. The outer surface of the conductive layer is coated with a medical pressure-sensitive adhesive. Multiple linear acupoint stimulators are arranged on the medical pressure-sensitive adhesive. Each acupoint stimulator is composed of multiple conductive threads and resin threads. The conductive threads are composed of a layer of polyester fibers wrapped around multiple bundles of polyacrylonitrile fibers, and the outer periphery of each polyester fiber and polyacrylonitrile fiber is coated with a conductive polymer.

[0054] The preparation method of polyacrylonitrile fiber and polyester fiber coated with conductive polymer is as follows: commercially available polyacrylonitrile fiber and polyester fiber are soaked in a polyaniline solution with a mass fraction of 8-20%, and then taken out and dried after a period of time.

[0055] <Example 2>

[0056] The eye periocular acupoint patch includes an overlapping and bonded auxiliary layer and a conductive layer. The auxiliary layer and the conductive layer are arranged with multiple mutually penetrating air holes. The outer surface of the conductive layer is coated with a medical pressure-sensitive adhesive. Multiple linear acupoint stimulators are arranged on the medical pressure-sensitive adhesive. Each acupoint stimulator is composed of multiple conductive threads and resin threads. The conductive threads are composed of a layer of polyester fibers wrapped around multiple bundles of polyacrylonitrile fibers, and the outer periphery of each polyester fiber and polyacrylonitrile fiber is coated with a conductive polymer.

[0057] The method for preparing polyacrylonitrile fiber coated with a conductive polymer mainly comprises the following steps:

[0058] Step 1: dissolving polyacrylonitrile in N,N-dimethylformamide solvent to prepare a polyacrylonitrile solution with a mass fraction of 10%;

[0059] Step 2: dissolving polyaniline doped with camphorsulfonic acid in N,N-dimethylformamide solvent to prepare a polyaniline composite solution with a mass fraction of 10%, wherein the molar ratio of camphorsulfonic acid to polyaniline is 0.1:1;

[0060] Step 3: The polyacrylonitrile solution prepared in step 1 and the polyaniline composite solution prepared in step 2 are respectively injected into the two solution channels of the coaxial electrospinning equipment, and the electrospinning parameters are adjusted. After electrospinning, the electrospun fibers are collected using a roller-assisted dynamic water bath, that is, the electrospun fibers are spun into a flowing water bath. When the fiber bundle flows to the bottom of the water tank with the water flow, it is wound on the roller under the action of the high-speed rotating roller to obtain polyacrylonitrile fibers coated with a conductive polymer on the outer periphery.

[0061] The preparation method of polyester fiber coated with conductive polymer mainly comprises the following steps:

[0062] Step a, dissolving polyethylene terephthalate in a mixed solvent of trifluoroacetic acid and dichloromethane in a volume ratio of 2:1 to prepare a polyester solution with a mass fraction of 10%;

[0063] Step b, dissolving polyaniline doped with camphorsulfonic acid in N,N-dimethylformamide solvent to prepare a polyaniline composite solution with a mass fraction of 10%, wherein the molar ratio of camphorsulfonic acid to polyaniline is 0.1:1;

[0064] Step c: injecting the polyester solution prepared in step a and the polyaniline composite solution prepared in step b into two solution channels of a coaxial electrospinning device respectively, and after electrospinning, collecting them in a drum-assisted dynamic water bath to obtain polyester fibers coated with a conductive polymer.

[0065] <Example 3>

[0066] The eye periocular acupoint patch includes an overlapping and bonded auxiliary layer and a conductive layer. The auxiliary layer and the conductive layer are arranged with multiple mutually penetrating air holes. The outer surface of the conductive layer is coated with a medical pressure-sensitive adhesive. Multiple linear acupoint stimulators are arranged on the medical pressure-sensitive adhesive. Each acupoint stimulator is composed of multiple conductive threads and resin threads. The conductive threads are composed of a layer of polyester fibers wrapped around multiple bundles of polyacrylonitrile fibers, and the outer periphery of each polyester fiber and polyacrylonitrile fiber is coated with a conductive polymer.

[0067] The method for preparing polyacrylonitrile fiber coated with a conductive polymer mainly comprises the following steps:

[0068] Step 1: dissolving polyacrylonitrile in N,N-dimethylformamide solvent to prepare a polyacrylonitrile solution with a mass fraction of 15%;

[0069] Step 2: dissolving polyaniline doped with camphorsulfonic acid in N,N-dimethylformamide solvent to prepare a polyaniline composite solution with a mass fraction of 10%, wherein the molar ratio of camphorsulfonic acid to polyaniline is 0.1:1;

[0070] Step 3: Inject the polyacrylonitrile solution prepared in step 1 and the polyaniline composite solution prepared in step 2 into the two solution channels of the coaxial electrospinning equipment respectively, adjust the electrospinning parameters, and after electrospinning, use a roller-assisted dynamic water bath to collect the polyacrylonitrile fibers coated with a conductive polymer.

[0071] The preparation method of polyester fiber coated with conductive polymer mainly comprises the following steps:

[0072] Step a, dissolving polyethylene terephthalate in a mixed solvent of trifluoroacetic acid and dichloromethane in a volume ratio of 2:1 to prepare a polyester solution with a mass fraction of 15%;

[0073] Step b, dissolving polyaniline doped with camphorsulfonic acid in N,N-dimethylformamide solvent to prepare a polyaniline composite solution with a mass fraction of 10%, wherein the molar ratio of camphorsulfonic acid to polyaniline is 0.1:1;

[0074] Step c: injecting the polyester solution prepared in step a and the polyaniline composite solution prepared in step b into two solution channels of a coaxial electrospinning device respectively, and after electrospinning, collecting them in a drum-assisted dynamic water bath to obtain polyester fibers coated with a conductive polymer.

[0075] Comparative Example 1

[0076] The eye acupuncture patch is the same as that in Example 1, except that the conductive thread is formed by winding a plurality of polyacrylonitrile fibers and polyester fibers, wherein the polyacrylonitrile fibers and polyester fibers are both commercially available.

[0077] Comparative Example 2

[0078] The eye periocular acupuncture patch is the same as that in Example 1, except that the conductive thread is composed of a plurality of polyacrylonitrile fibers, wherein the polyacrylonitrile fibers are commercially available.

[0079] Comparative Example 3

[0080] The eye periocular acupuncture patch is the same as that in Example 1, except that the conductive thread is composed of a plurality of polyester fibers, wherein the polyester fibers are all commercially available.

[0081] Comparative Example 4

[0082] The eye periocular acupuncture patch is the same as that in Example 2, except that the conductive thread is formed by winding a plurality of polyacrylonitrile fibers and polyester fibers blended with a conductive polymer.

[0083] The method for preparing polyacrylonitrile fiber blended with a conductive polymer mainly comprises the following steps:

[0084] Step 1: dissolving polyacrylonitrile in N,N-dimethylformamide solvent to prepare a polyacrylonitrile solution with a mass fraction of 10%;

[0085] Step 2: dissolving polyaniline doped with camphorsulfonic acid in N,N-dimethylformamide solvent to prepare a polyaniline composite solution with a mass fraction of 10%, wherein the molar ratio of camphorsulfonic acid to polyaniline is 0.1:1;

[0086] Step 3: Mix and stir the polyacrylonitrile solution prepared in step 1 and the polyaniline composite solution prepared in step 2, degas, and then inject them into the solution channel of ordinary electrospinning, adjust the electrospinning parameters, and after electrospinning, use a drum-assisted dynamic water bath to collect to obtain polyacrylonitrile / polyaniline blended fibers.

[0087] The preparation method of polyester fiber blended with a conductive polymer mainly comprises the following steps:

[0088] Step a, dissolving polyethylene terephthalate in a mixed solvent of trifluoroacetic acid and dichloromethane in a volume ratio of 2:1 to prepare a polyester solution with a mass fraction of 10%;

[0089] Step b, dissolving polyaniline doped with camphorsulfonic acid in N,N-dimethylformamide solvent to prepare a polyaniline composite solution with a mass fraction of 10%, wherein the molar ratio of camphorsulfonic acid to polyaniline is 0.1:1;

[0090] Step c, mixing and stirring the polyester solution prepared in step a and the polyaniline composite solution prepared in step b, degassing, and then injecting them into the solution channel of ordinary electrospinning, adjusting the electrospinning parameters, and after electrospinning, using a drum-assisted dynamic water bath to collect, to obtain polyester / polyaniline blended fibers.

[0091] <Conductive yarn conductivity test>

[0092] The conductive yarns used in Examples 1 to 3 and Comparative Examples 1 to 4 were tested for their conductive properties. The test results are shown in Table 1.

[0093] Table 1

[0094] Conductivity / (S / cm) Example 1 <![CDATA[10 -5 ]]> Example 2 <![CDATA[10 -2 ]]> Example 3 <![CDATA[10 -2 ]]> Comparative Example 1 <![CDATA[10 -12 ]]> Comparative Example 2 <![CDATA[10 -12 ]]> Comparative Example 3 <![CDATA[10 -12 ]]> Comparative Example 4 <![CDATA[10 -8 ]]>

[0095] As can be seen from Table 1, the commercially available polyacrylonitrile fibers and polyester fibers in Comparative Examples 1 to 3 have very poor electrical conductivity, while in Example 1, the commercially available polyacrylonitrile fibers and polyester fibers are coated with conductive polyaniline by the impregnation method, and the conductivity of the conductive filaments formed is increased. The fibers prepared by the coaxial electrospinning method in Examples 2 to 3 have a core-shell structure, wherein the cores are polyacrylonitrile fibers and polyester fibers, respectively, and the shell is polyaniline, which can further increase the conductivity of the conductive filaments. In Comparative Example 4, polyacrylonitrile and polyester are blended with polyaniline respectively by the blending spinning method and then electrospun, and the conductivity of the conductive filaments formed in this way increases less. This is mainly because the viscosity of the polymer solution is large when polyaniline is mixed with polyacrylonitrile or polyester by blending, making it difficult to mix them fully and evenly, which leads to poor uniformity of the blended fibers obtained, and the conductivity of the conductive filaments finally formed does not change much. Compared with the coaxial spinning of each fiber in Examples 2 to 3, the conductive material is wrapped around the polyacrylonitrile fiber and polyester fiber by an impregnation method in Example 1, and the wrapping uniformity is poor, resulting in the conductivity of the conductive thread in Example 1 being lower than that in Examples 2 to 3. However, for the acupuncture point patch, the conductive thread in Example 1 is sufficient to allow biocurrent to flow.

[0096] <Far-infrared effect test of eye acupuncture point patch>

[0097] Take the eye acupuncture point patch prepared in Example 1 and use an infrared thermal imager to test its far infrared effect. The results are as follows: Figure 5 As shown in Table 2, testing of this eye patch at 36°C revealed a normal emissivity of 0.77, with a far-infrared wavelength range of 4-20μm. This radiation wavelength matches the peak wavelength of the human body surface, enabling resonance between small molecules in tissues, thereby activating cells and promoting blood circulation. It also nourishes the lacrimal and meibomian glands, increasing tear secretion and prolonging tear film breakup time, alleviating dry eye symptoms.

[0098] Table 2 Far infrared test

[0099] Test items Test results temperature Normal emissivity 0.77 36℃ Infrared radiation spectrum See Figure 5 36℃

[0100] <Effectiveness Test of Eye Acupuncture Patch>

[0101] Under the guidance of professionals, the periocular acupoint patches prepared in Example 2 and Comparative Example 4 were applied to the Tongziliao, Sibai, and Jingming acupoints bilaterally. Thirty subjects were placed in each group and applied for four hours daily for two weeks. The average tear film breakup time and tear meniscus height were measured using a Diamecon Keratograph ocular surface analyzer (77000). The test results are shown in Table 3.

[0102] Table 3 Effects of eye acupoint patch on tear film breakup time

[0103] Before use Week 1 Week 2 Example 2 4.52±3.41 6.86±3.52** 8.21±2.35** Comparative Example 4 4.49±3.22 5.13±4.01 6.38±2.78*

[0104] Note: *P<0.05, **P<0.01 for before-after comparison.

[0105] The increase in tear film breakup time indicates that the degree of dry eye has improved. As shown in Table 2, compared with before use, the average tear film breakup time of the subjects increased after using the eye periocular acupoint patch prepared in Example 2 of the present invention, and the effect was better than the eye patch in Comparative Example 4.

[0106] Table 4 Effects of eye acupoint patch on tear meniscus height

[0107] Before use Week 1 Week 2 Example 2 0.18±0.03 0.21±0.05* 0.23±0.06** Comparative Example 4 0.18±0.05 0.19±0.03 0.21±0.04*

[0108] Note: *P<0.05, **P<0.01 for before-after comparison.

[0109] The increase in tear meniscus height indicates that the degree of dry eye has improved. As shown in Table 3, compared with before use, the tear meniscus height of the subjects increased after using the eye periocular acupoint patch prepared in Example 2 of the present invention, and the effect was better than the eye patch in Comparative Example 4.

[0110] Table 5 Effectiveness of eye acupoint patch in improving dry eyes

[0111]

[0112] Based on the relief of dry eye symptoms, average tear film breakup time, and tear meniscus height in the subjects, the effective rates of the eye patch group of Example 2 were 73.3% and 83.3% in the first and second weeks, respectively, and the effective rates of the eye patch group of Comparative Example 4 were 26.7% and 60% in the first and second weeks, respectively. From the perspective of overall effectiveness, the eye periocular acupoint patch prepared in Example 2 of the present invention is better than the eye patch of Comparative Example 4.

[0113] In summary, the acupoint stimulator and the conductive layer in the eye periocular acupoint patch of the present invention are conductive structures, which can normalize the disordered and ineffectively conducted bioelectricity, normalize the conducted bioelectricity, and restore the bioelectricity of the damaged area. When applied to the meibomian gland area under the Sibai acupoint, it promotes the recovery of meibomian gland function and thus improves dry eye symptoms. When applied to the Tongziliao and Jingming acupoints, the principles of acupoint selection and acupuncture in traditional Chinese medicine are used. The acupoint stimulator is a structure that generates pressure, and the movement of the muscles around the eyes is driven by eye movement and blinking, thereby strengthening the stimulation of the acupoints. The intensity of the acupoint can dredge the meridians around the eyes, promote the smooth flow of blood around the eyes, and relieve symptoms such as dry eyes caused by dryness, foreign body and fatigue. In addition, the location of the Jingming acupoint is where the tear ducts are densely packed, which can also dredge the tear ducts and relieve discomfort such as tears. The acupoint stimulator and the conductive layer work together to play a far-infrared role, generating far-infrared rays with peak matching wavelengths covering the surface of the human body, which can cause small molecules between tissues to resonate, and through the resonance effect, activate cells, promote blood circulation, and nourish the lacrimal glands and meibomian glands, thereby increasing tear secretion and prolonging the tear film rupture time, and relieving dry eyes.

[0114] The number of devices and processing scales described herein are intended to simplify the description of the present invention. Applications, modifications, and variations of the present invention will be readily apparent to those skilled in the art.

[0115] Although the embodiments of the present invention have been disclosed above, they are not limited to the applications listed in the description and implementation methods. They can be fully applied to various fields suitable for the present invention. For those familiar with the art, additional modifications can be easily implemented. Therefore, without departing from the general concept defined by the claims and the scope of equivalents, the present invention is not limited to the specific details and illustrations shown and described herein.

Claims

1. Eye acupuncture point patch, characterized by: The device comprises an auxiliary layer and a conductive layer that are overlapped and bonded together. The auxiliary layer and the conductive layer are provided with a plurality of mutually interpenetrating air holes. The outer surface of the conductive layer is coated with a medical pressure-sensitive adhesive. A plurality of linear acupoint stimulators are arranged on the medical pressure-sensitive adhesive. Each acupoint stimulator is composed of a plurality of resin filaments and a conductive filament. The conductive filament is composed of a layer of polyester fiber wrapped around a plurality of bundles of polyacrylonitrile fiber. The outer periphery of each polyester fiber and polyacrylonitrile fiber is coated with a conductive polymer. The preparation method of polyester fiber coated with conductive polymer mainly comprises the following steps: Step a, dissolving polyethylene terephthalate in a mixed solvent of trifluoroacetic acid and dichloromethane in a volume ratio of (2-4):1 to prepare a polyester solution with a mass fraction of 8-20%; Step b, dissolving polyaniline doped with camphorsulfonic acid in N,N-dimethylformamide solvent to prepare a polyaniline composite solution with a mass fraction of 8-20%, wherein the molar ratio of camphorsulfonic acid to polyaniline is (0.01-0.2):1; Step c: injecting the polyester solution prepared in step a and the polyaniline composite solution prepared in step b into two solution channels of a coaxial electrospinning device respectively, and after electrospinning, collecting them in a drum-assisted dynamic water bath to obtain polyester fibers coated with a conductive polymer.

2. The eye periocular acupuncture patch according to claim 1, characterized in that: The preparation method of polyacrylonitrile fiber coated with a conductive polymer mainly comprises the following steps: Step 1: dissolving polyacrylonitrile in N,N-dimethylformamide solvent to prepare a polyacrylonitrile solution with a mass fraction of 8-20%; Step 2: dissolving polyaniline doped with camphorsulfonic acid in N,N-dimethylformamide solvent to prepare a polyaniline composite solution with a mass fraction of 8-20%, wherein the molar ratio of camphorsulfonic acid to polyaniline is (0.01-0.2):1; Step 3: Inject the polyacrylonitrile solution prepared in step 1 and the polyaniline composite solution prepared in step 2 into the two solution channels of the coaxial electrospinning equipment respectively, adjust the electrospinning parameters, and after electrospinning, use a roller-assisted dynamic water bath to collect the polyacrylonitrile fibers coated with a conductive polymer.

3. The eye periocular acupuncture patch according to claim 1, characterized in that: Each acupoint stimulation body is arranged in parallel with a plurality of air holes located in the same row.

4. The eye periocular acupuncture patch according to claim 1, wherein: Each acupoint stimulator consists of a conductive wire and two resin wires.

5. The eye periocular acupuncture patch according to claim 4, characterized in that: The two resin wires of each acupoint stimulating body are symmetrically arranged side by side on both sides of the conductive wire.

6. The eye periocular acupuncture patch according to claim 1, characterized in that: The auxiliary layer is medical non-woven fabric, and the conductive layer is conductive foil.

7. The eye periocular acupuncture patch according to claim 1, characterized in that: The resin filaments are polyamide fibers.

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