Antiparasitic isoxazoline compounds, long-acting injectable formulations containing them, methods and uses thereof
By developing long-acting injectable compositions containing isoxazoline compounds, liquid PEGs and neutral oils, the problems of insufficient bioavailability and large stimulation of injection sites in the prior art are solved, and rapid and efficient prevention and control of fleas and ticks are achieved, and parasite control of various animals and crops are suitable for parasite control.
Patent Information
- Application Number
- CN202210192289.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Priority Date
- 2016-08-25
- Filing Date
- 2017-02-24
- Publication Date
- 2025-07-25
- Estimated Expiration
- 2037-02-24
AI Technical Summary
The existing isoxazoline active agent compositions have shortcomings in terms of bioavailability and sustained efficacy, especially in long-acting injectable compositions, the prevention and treatment of fleas and ticks is poor, and the injection site is highly irritated.
Develop long-acting injectable compositions containing an antiparasitic effective amount of isoxazoline compound, liquid PEG and pharmaceutically acceptable neutral oil, combined with optional co-solvents and additives, avoiding the use of pharmaceutically biodegradable polymers, increasing bioavailability and reducing injection site irritation.
It has achieved rapid onset and long-term prevention and control of parasites such as fleas and ticks, reduced stimulation at the injection site, and provided a suitable safety spectrum, suitable for parasite control in a variety of animals and crops.