Therapeutic device for painful inflammatory diseases and for neuromuscular and neuro-postural adjustment

Abstract

The therapeutic device of the present invention consists of a support to be placed on the patient's skin and is made of specific nanocrystals that, when suitably activated, generate electromagnetic emissions that have beneficial effects on the patient's inflammatory, painful diseases and neuromuscular and postural adjustments.

Description

Technical Field

[0001] The present invention relates to a device that allows you to treat painful inflammatory diseases and also allows you to make neuromuscular and postural adjustments. Background Technology

[0002] It is known that the human body is sensitive to electromagnetic radiation. One example of this sensitivity is the body's ability to respond to sunlight through the synthesis of specific molecules. For instance, sunlight stimulation promotes the synthesis of vitamin D, which has important effects on the immune system and on calcium fixation in bones (a biostimulant that accelerates calcium recalcification).

[0003] Many of these biological phenomena are still under study, and some have not yet been fully explored and understood.

[0004] However, based on specific natural effects such as human body exposure to sunlight, there have been attempts to place the human body under very intense lasers for therapeutic purposes to obtain more significant effects, or at least equivalent to those obtained through sunlight exposure.

[0005] The current results are not very satisfactory, and the laser treatment currently used uses rather limited and low-intensity lasers.

[0006] However, exposure to these lasers is always very short because the large machines in physiotherapy centers need to be available to a large number of patients.

[0007] Furthermore, it has been observed that the light frequencies emitted by these lasers are specifically targeted for therapeutic purposes. Therefore, patients suffering from multiple diseases or those for whom various treatments have been ineffective should be treated with different laser energies and various treatment courses.

[0008] They also exist in the field of electronic components, which emit photons of a selected wavelength when stimulated by a specific wavelength. These components are used to create optoelectronic panels and to fabricate nanocrystal video displays.

[0009] No one had yet thought of using these components in the therapeutic field, partly because most of them have completely different applications and methods, even though they have frequencies very close to the target frequency.

[0010] For a long time, infrared irradiation of human skin has been used in physical therapy applications, using low infrared emission frequencies between 760-1500nm to generate a heating effect and high emission power with 150-1500W infrared lamps.

[0011] This type of heating has been found to be too intense and often unbearable.

[0012] Moreover, although such treatment is called physical therapy, the purpose of this treatment is to treat only the surface layer of the epidermis.

[0013] Recent findings have shown that patients are also more able to tolerate the use of lasers and / or nanocrystals in the low infrared emission frequency range of 1100-1400 nm for physical therapy applications. However, these applications require a nearby and continuously active emission source to stimulate the nanocrystals, which can reach 50W.

[0014] The need for such high-powered excitation lamps makes the aforementioned devices reliant on a fixed power source, and therefore, they are not portable. Consequently, treatments using such nanocrystal and / or laser-based devices are time-limited, restricted to the duration of infrared irradiation applications only at healthcare facilities equipped with the aforementioned devices.

[0015] Further applications of lasers or nanocrystals in the medical treatment of the skin's surface layer have indeed confirmed that wavelengths between 613 and 846 nm are effective in treating skin lesions.

[0016] However, these patches are only effective when exposed to ambient light (light shining on the outer surface of the patch). However, to achieve a therapeutic effect, these patches raise the skin temperature, and the nanocrystal emission field is in the low infrared range and cannot tolerate prolonged exposure to the external environment, causing redness and inflammation at the site of injury beneath the patches. For this reason, the nanocrystals are spaced apart to allow ambient light to pass through the spaces between them. If they are applied to a patient's skin but concealed under clothing, this prevents the patches from receiving ambient light on their outer surfaces, and the nanocrystals will not emit radiation intended for treating skin injuries.

[0017] In the context of the aforementioned applications of nanocrystal patches, there are also bandages or other devices that, when applied to a patient's skin, are effective for treating exposed and external parts of the body. The external portion of such bandages or other devices, relative to the portion placed on the body, must be hit by external radiation and scatter therapeutic radiation toward the skin; however, these devices appear to be ineffective, and in fact, they require:

[0018] - The outer area is used to collect external incident radiation;

[0019] - A guiding device for precisely directing incident radiation toward the nanocrystal by emitting a specific frequency:

[0020] - Launch area

[0021] -Requirement: For it to function, the external incident area must be larger than the emission area, and ultimately...

[0022] - It requires other devices to increase the proportion of electromagnetic radiation collected by the collection surface and transmitted to the guiding device.

[0023] However, these devices are not suitable for continuous application to the body, and therefore must be removed periodically, such as when going to bed. Thus, it is evident that the bandages are unsuitable for low-frequency, continuous treatment of internal ailments of the human body due to their limited radiation effects, the need for continuous external irradiation to be effective, the inability to maintain constant contact with the body, and, most importantly, the requirement for a surface area much larger than the treatment surface.

[0024] Further and different applications involve the use of nanocrystals for phototherapy, which requires a specific LED emission source that is converted into a specific wavelength by the nanocrystals.

[0025] However, these applications do not specify the emission power for both the LED source and the nanocrystal, leaving it to the user's subjective choice. In most applications, this results in ineffective treatment due to excessive radiation. Many users experience discomfort during treatment, including with radiation from low-infrared wavelength components, particularly at intensities greater than 1 mW / cm². Even in these other and varied applications, ultra-low-power treatment of internal ailments lacks continuity.

[0026] The purpose of this invention

[0027] The objective of this invention is to make treatment or healing devices more readily available for use on the human body for health benefits.

[0028] Another objective of the present invention is to provide a treatment device that is effective for most people suffering from acute pain or inflammation.

[0029] Another object of the present invention is to provide an effective and easily adjustable treatment device.

[0030] Another objective of the present invention is to provide a therapeutic device that can be constructed at low cost, requires little maintenance, and also has low energy consumption.

[0031] Another objective of the present invention is to provide a treatment device that is particularly effective for muscle relaxation.

[0032] Another objective of the present invention is to provide a therapeutic device that is particularly effective for posture adjustment.

[0033] An important objective of this invention is to provide a treatment device that provides long-term effects and has no significant power consumption during treatment.

[0034] Another important objective of the present invention is to provide a treatment device that can be used without causing deterioration.

[0035] A different objective of the present invention is to provide a therapeutic device that works even without direct external radiation.

[0036] Another objective of the present invention is to provide an apparatus having synergistic and combined effects of medical treatment.

[0037] An important objective of this invention is to provide a device whose specific emission power does not cause inflammation of human skin and, therefore, allows for continuous contact with the skin, even for several days or even overnight. Summary of the Invention

[0038] All of the foregoing objectives, and other objectives, will become more apparent from the following explanation and can be achieved by the apparatus of the present invention according to the following description.

[0039] The present invention comprises a combination of at least one support sheet element (hereinafter also referred to as: support) and at least two quantum dots selected from the following:

[0040] - Graphene quantum dots, code 900708 or having fluorescence indicators corresponding to: λex 350nm; λem 445nm, full width at half maximum (FWHM) 65nm, quantum dots with quantum yield >65%.

[0041] - Blue luminescent graphene quantum dots, code 900726, or those exhibiting fluorescence approximately corresponding to: λex 350nm; λem 445nm±10nm, FWHM 75nm, and quantum dots with a quantum yield ≥20%.

[0042] - Cyan-emitting graphene quantum dots, code 900707 or with fluorescence indicators corresponding to: λem 475-495nm, FWHM 70nm, quantum dots with a quantum yield >17%.

[0043] - Aqua-green luminescent graphene quantum dots, code 900712 or having fluorescence indicators corresponding to: λex 485nm, λem 530nm±10nm, FWHM 80 nm, quantum dots with a quantum yield ≥17%;

[0044] - Perovskite quantum dots coated with oleic acid and oleylamine, code 900747 or having a fluorescence indicator corresponding to: quantum dots with λem 480nm;

[0045] -COOH functionalized CdTe nucleotype quantum dots, code 777978 or having fluorescence indicative properties corresponding to: quantum dots with a wavelength of λem 710 nm and a quantum yield ≥15%.

[0046] - Oleic acid-functionalized CdS / ZnS core-shell quantum dots, code 900286, or those with fluorescence indicators corresponding to: λmax 385nm; λem 400nm±10nm, quantum dots with quantum yield >50%;

[0047] - Oleic acid-functionalized CdS / ZnS core-shell quantum dots, code 900283 or having fluorescence indicators corresponding to: λ maximum 405 nm; λ em 425 nm ± 10 nm quantum dots;

[0048] The support is composed of a sheet-like element made of a material transparent at a reference wavelength or at the wavelength of radiation emitted by the human body. A first side of the sheet-like support is adapted to directly contact the skin of a person with a disease or inflammatory condition to be treated. A mixture of at least two of the quantum dots, at a concentration of 1 mg / cm² to 100 mg / cm², is present on the opposite side of the first side of the support, or incorporated into or dispersed within the sheet-like element itself. This mixture is capable of emitting photons at a reference wavelength when stimulated by at least infrared, visible, or ultraviolet electromagnetic radiation, having an intensity between 0.1 mW / cm² and 0.5 mW / cm², and preferably between 0.2 mW / cm² and 0.4 mW / cm². The reference wavelength is between 280 and 740 nm, and preferably between 350 nm and 530 nm.

[0049] Advantages of the present invention

[0050] Advantageously, the support is made of a material that is transparent to at least infrared, light, or ultraviolet electromagnetic radiation, wherein the radiation has wavelengths capable of exciting the mixture of the aforementioned quantum dots, and wherein the patient’s body heat itself is understood as electromagnetic emission in the infrared spectrum, and other electromagnetic radiation of the human body, including UV, excites the quantum dots.

[0051] Advantageously, the support is made of a plastic material that can connect to the patient's epidermis, prevent deterioration due to sweat emanating from the skin, and prevent sweat from migrating through the support, since sweat can cause deterioration of quantum dots or mixtures of quantum dots.

[0052] Advantageously, the support is made of a flexible material that can connect to the patient's epidermis and follow the movement and / or deformation of the skin without falling off, wherein the support preferably has a thickness between 0.05 mm and 2 mm, and more preferably between 0.1 mm and 1 mm, to better adapt to the deformation of the epidermis.

[0053] Advantageously, the quantum dot mixture is distributed on the support, so that it occupies most of one side of the surface (on which the mixture is applied), similar to a varnish, using the entire surface for efficient transmission of the radiation, not blocked by the overlapping of quantum dots, and having a thickness between 0.001 and 1 mm.

[0054] Advantageously, the quantum dot mixture is arranged in discrete regions on the support to concentrate the radiation flow in specific areas, thereby making it strong enough to be absorbed by the support, having a thickness range of 0.005 to 1 mm.

[0055] Advantageously, the sheet-like support element (hereinafter also referred to as the support) is coupled to a second sheet-like protection and restraint element (hereinafter also referred to as the protection element or protective element), which includes and restrains the mixture of quantum dots, protecting them from external agents or mechanical stresses that could damage them.

[0056] Advantageously, the second sheet element is composed of a material that is transparent to infrared radiation or light radiation in the visible or ultraviolet spectrum, such that the radiation from the outside and passing through the second sheet element can excite the mixture of the aforementioned quantum dots to emit the desired frequency.

[0057] Advantageously, the protective member has an extension comparable to that of the support member, and its surface facing the support member (1) abuts against it, retaining and sealing the mixture of quantum dots.

[0058] Advantageously, the protective element consists of a protective transparent ink or plastic film that can reduce the thickness of the device and make the device easier to wear.

[0059] Advantageously, the mixture of quantum dots is diluted in ink so that the quantum dots can be printed on the support or the protective element, directly on the opposing sides, making it easier to position and arrange the quantum dots.

[0060] Advantageously, the ink is a transparent ink, such that only the characteristics of the binder and the ink are implemented in the dispersion medium, and all emitted photons and incoming radiation can reach the quantum mixture with minimal attenuation.

[0061] Advantageously, the device has a minimum thickness to maintain a high degree of elasticity and allows it to adapt to the surface stress of the skin without cracking, breaking, or tearing.

[0062] Advantageously, the connection between the leather and the support and / or the support and the protective element is achieved using a flexible double-sided tape, which provides the greatest degree of handling freedom when selecting the material of the support and / or the protective element, relative to their fabrication material and thickness.

[0063] Advantageously, the double-sided adhesive material, at least along the peripheral edge of the device, between the support layer and the protective layer, effectively incorporates the quantum dots, preventing the quantum dots from dispersing outside the device itself and preventing nanotechnology materials contained in or escaping from the device from coming into contact with the user's skin.

[0064] Advantageously, the device is laser-cut from a multi-sheet plate, thus the laser cutting enables the edges of the device in its multiple layers to be sealed, forming a tight seal that holds the quantum dots in the device and prevents any outward dispersion.

[0065] Advantageously, the device can be largely transparent and skin-adherent, placed near primary and secondary extremities, tendons, muscles, dermatomes, and nerve endings to facilitate neuromuscular and postural adjustments, enabling the examination of any redness of the skin.

[0066] Advantageously, the wearable therapeutic device exerts greater activity of the quantum dot mixture (2) when it has an ink comprising 5 to 80% carbon nanotubes and a quantum dot mixture of 95 to 20%, depending on the type of quantum dots used and the target frequency of the therapeutic radiation, and manages the calibration, relimitation, and determination of the amount of photons emitted by the device according to the patient’s needs and desired stimulation.

[0067] Advantageously, the mixture of quantum dots comprises two or more of the following quantum dots:

[0068] - Graphene quantum dots, code 900708 or having fluorescence indicators corresponding to: λex 350nm; λem 445nm, FWHM 65nm, quantum dots with quantum yield >65%;

[0069] - Blue luminescent graphene quantum dots, code 900726 or the fluorescence approximation shown corresponds to: λex 350nm; λem 445nm±10nm, FWHM 75nm, quantum dots with a quantum yield ≥20%.

[0070] - Cyan-emitting graphene quantum dots, code 900707 or the fluorescence indicator shown corresponds to: λem 475-495nm, FWHM 70nm, quantum dots with a quantum yield >17%.

[0071] - Aqua-green luminescent graphene quantum dots, code 900712 or the fluorescence indicator shown corresponds to: λex 485nm, λem 530 nm±10nm, FWHM 80 nm, quantum dots with a quantum yield ≥17%.

[0072] - Perovskite quantum dots coated with oleic acid and oleylamine, code 900747 or the fluorescence indicator shown corresponds to: quantum dots with a wavelength of λem480nm;

[0073] -COOH functionalized CdTe nucleotype quantum dots, code 777978 or the fluorescence indicator shown, correspond to: quantum dots with a wavelength of λem 710 nm and a quantum yield ≥15%.

[0074] - Oleic acid-functionalized CdS / ZnS core-shell quantum dots, code 900286, or those showing fluorescence indicators corresponding to: λmax 385nm; λem 400nm±10nm, quantum dots with quantum yield >50%;

[0075] - Oleic acid-functionalized CdS / ZnS core-shell quantum dots, code 900283 or the fluorescence indicator shown corresponds to: λ maximum 405 nm; quantum dots with λ em 425 nm ± 10 nm;

[0076] It allows the generation or attainment of the same wavelength as ULLLT (Ultra-Low Level Laser Therapy) at ultra-low intensity, without saturation effects and without the side effects of conventional laser or light therapy due to the excess intensity of the photon emission stream from the quantum dot mixture.

[0077] The quantum dot is therefore also defined as an upconversion nanocrystal. These and other objectives can all be achieved by the device of the present invention according to the appended claims. Summary of the Invention

[0079] For use in treating painful and / or inflammatory conditions and for neuromuscular and postural adjustment, the present invention aims to provide a device based on the technology of developing nanoscale crystals that, when properly stimulated, are capable of emitting photons at a precise frequency specific to each quantum dot within a quantum dot. As an example of one of the aforementioned benefits, these photons emitted within a precise frequency range stimulate the human body to achieve neuromuscular rebalancing. The synergistic effect of all or part of the aforementioned benefits—alleviating severe inflammatory states and / or modulating neuromuscular energy states and / or adjusting postural structures—is achieved solely through the combination of two or more electromagnetic emissions from the quantum dot mixture, which would not be fully apparent when using individual quantum dots or individual families within the quantum dot mixture.

[0080] Moreover, it has been verified that only treatment devices that are continuously used for a period of time, remain constantly active, and are placed on human skin can achieve the aforementioned medical treatment effects, for example, for one or more days including nights, and have an ultra-low power, that is, an emission intensity of less than 0.5mW / cm2.

[0081] Devices that are insufficient in treatment and / or have an intensity higher than the aforementioned emission intensity exhibit saturation effects and sometimes cause inflammation, and therefore differ from the therapeutic effects of the device of the present invention, and violate the biological principles of cell stimulation by electromagnetic radiation.

[0082] Furthermore, prolonged exposure to infrared or low-infrared radiation, such as the use of quantum dots with frequencies above 760 nm, inevitably leads to local inflammation and, in some cases, people find these devices intolerable due to continuous and persistent erythema allergies. Attached Figure Description

[0083] The technical features of the present invention, in accordance with the foregoing objectives, will become clearly apparent in the following claims, and its benefits will also become more apparent in the detailed description following with reference to the accompanying drawings, in which preferred embodiments are shown as examples only and not as limitations.

[0084] Figure 1 An example of the apparatus of the present invention is shown.

[0085] Figure 2 An improved embodiment of the device of the present invention is shown.

[0086] Figure 3 This shows the treatments patients experienced during data acquisition.

[0087] Figure 4 This illustrates the use of the device of the present invention in the same patient.

[0088] Figure 5 A table showing values ​​obtained by means of advanced medical diagnostic tools EMG and K7 Kinesiograph before and after the use of the present invention is presented in a comparative manner.

[0089] Figure 6-8 These are images of the temperature of the inflamed area in the infrared and visible spectra, and images of the same area after 24 hours of using the device of the present invention.

[0090] Figure 9-11 The figures are illustrations of stability measurements before and after the application of the device of the present invention, and tables highlighting the usefulness of the present invention for posture adjustment.

[0091] Figure 12-14 The results show the application of the device of the present invention to a subject with multiple sclerosis. Detailed Implementation

[0092] Referring to the accompanying drawings, the device of the present invention consists of two transparent plastic sheet layers, a transparent insulating plastic sheet element 1 and an insulating transparent plastic sheet element 4, preferably flexible, the first having a supporting function and the second having a protective and insulating function, which surrounds and confines the mixture 2 of quantum dots.

[0093] Typically, this mixture also includes a certain percentage of carbon nanotubes, thus achieving a precise percentage of the quantum dot mixture 2, and also, due to their conduction effect, allowing the radiation stimulating the quantum dots to be received and thus allowing the photon emission of the mixture to be transmitted to the outside of the device.

[0094] To facilitate printing on the wall between the two outer layers of the quantum dot mixture, the mixture is dispersed in a transparent ink. To ensure the flexibility of the device and prevent the two outer layers 1, 4 from separating, a double-sided adhesive 3, preferably suitable for contact with human skin, is used, which can keep the two layers 1, 4, comprising the quantum dot mixture 2, bonded together.

[0095] To make the device more flexible, the outer layer is limited to a thickness of a few tenths of a millimeter to a few millimeters to prevent breakage or cracking during large bending.

[0096] The flexible double-sided adhesive 3 also makes the device more reliable over a longer period of time, as it has a greater elastic modulus than the layers. However, the adhesive may cause the layers of the composite device to slip.

[0097] The wall of support 1 will come into contact with the patient’s skin, either directly on the skin to be treated or by filling it with removable ointment.

[0098] The device is applied at points precisely placed on the skin or in nerve centers: these are primary and secondary nerve endings of tendons, muscles, dermis, and nerve endings, at locations where you wish to stimulate neuromuscular and postural adjustments, pain, and inflammation.

[0099] These emissions are of a very moderate size, comparable to the intensity of ULLLT (Ultra-Low Level Laser Therapy), and in fact, they can be applied continuously (even 24 hours a day) and are precisely focused on the desired wavelengths, enabling the achievement of the effects and results of this invention.

[0100] In fact, long-term, sustained, and effective results can be achieved simply by providing a combination of relaxation-relieving and pain-reducing reflexes and reflexes that treat neuromuscular modulation.

[0101] First application example ( Figure 3-5 )

[0102] In a non-limiting instance, this section describes the application of neuromuscular modulation in patients with tense masticatory muscles.

[0103] These accompanying figures illustrate how the EMG electromyography scanner (K7) was implemented in patients with temporomandibular joint dysfunction, with and without the device of this invention, as assessed by a jaw dentist.

[0104] All measurements on the left side of the screen were collected before application, and all measurements on the right side of the screen were collected a few minutes after the invention was applied.

[0105] Values ​​greater than 2.4 uV are considered excessive muscle response / stress.

[0106] As can be seen from the figure, the treated RMM (right masseter), LMM (left masseter), LTA (left temporal anterior), RTA (right temporal anterior), LSM (left SCM), and RSM (right SCM) muscles, as indicated by EMG muscle electroactivation measurements, showed reduced resting tension.

[0107] We can see that muscle activation normalizes in a resting state, managing the patient's tension.

[0108] In the left-hand chart without the device, many muscles are actually overstimulated, meaning the resting values ​​are greater than 2.3 uV, with an average of 2.6 uV. In the right-hand chart, the measurements were taken after applying the device symmetrically. We can see that the patient's condition has largely normalized, with most muscles decreasing to below 2.4 uV after a few minutes, with an average of 2.1 uV.

[0109] Second application example ( Figure 6-8 )

[0110] Figure 6 The image shows the temperature record of inflammation in a partial injury to the right rectus femoris tendon of an Italian Serie A football player.

[0111] Figure 8 middle,( Figure 8 Temperature record view and corresponding Figure 7 (Visible view in the middle) reference Figure 6 Temperature records of the same patient's same lower limb showed reduction in inflammation and the inflamed area after appropriate application of some of the devices 24 of the present invention near the inflamed part.

[0112] Third Application Example ( Figure 9-11 )

[0113] The application of the device of the present invention has yielded unexpected postural adjustments. In fact, according to the stability measurement (Cyber ​​Sabot) and the evaluation in accordance with the Ministry of Health's guidelines on posturals, before the device of the present invention was applied to patients with polymyalgia rheumatica (…), Figure 9 ) and afterwards ( Figure 10We can see, for example, the posture oscillations of ) Figure 11 As shown in the table, the area decreased significantly from 359 sq. mm to 98 sq. mm (measured immediately a few minutes after application). Therefore, the application of the device of the present invention is beneficial for saving a significant amount of energy when managing upright posture; this energy is still available to the body for other metabolic functions.

[0114] Fourth application example ( Figure 12-14 )

[0115] The results obtained by the device of the present invention are surprisingly effective when applied to people with multiple sclerosis.

[0116] These results are based on the following assessment:

[0117] - Figure 12 Accelerometer tests of hip rotation and lumbar flexion; Figure 13 The International EDSS Index (Extended Disability Score – for assessing the degree of disability in patients with multiple sclerosis) is calculated.

[0118] - Figure 14 The SF36 self-assessment test (a questionnaire on patient health).

[0119] Reference Figure 12-13 -14:

[0120] -T0 refers to the patient's condition without the device.

[0121] -T1 The device of the present invention is used for 30 minutes;

[0122] -T2 The device of the present invention is used for 3 months, and the device is used continuously;

[0123] -T4 The device of the present invention is used for 1 year, and the device is used continuously.

[0124] Results Commentary

[0125] Accelerometer test

[0126] In the right hip flexion, left hip flexion, and lumbar flexion diagrams, flexion from T0 to T4 showed significant improvement, namely, rotational capacity of the right hip (p<0.05) and left hip (p<0.01), and even a significant increase in lumbar flexion (flexion-extension) (p<0.0009).

[0127] It should be noted that the improvement was significant at 3 months (T3) and remained constant during the one-year control period (T4), demonstrating the stability of the efficacy.

[0128] EDSS

[0129] This index showed a significant improvement from a mean of 4.9 at T0 to 4.7 at T4. This data was highly significant (p<0.002), especially considering that these data should have worsened over time in these patients.

[0130] SF36

[0131] Self-assessment of SF36 showed significant improvement in patients at 3 months, and then remained constant at one year.

[0132] Improvements were observed in the physical, emotional, and social domains, but the improvements were more pronounced in the emotional-social domain. In particular, regarding the physical domain, improvements were seen in physical activity, limitations in physical roles, pain, general health, vitality, and the Physical Health Index (PHI).

[0133] As a result of improvements in social activities in the emotional-social domain, limitations of emotional roles, mental health, and mental health indices.

Claims

1. A therapeutic device applied to the skin corresponding to primary and secondary nerve endings, muscles, dermatomes, and nerve endings of tendons, wherein the therapeutic device is advantageous for the re-adjustment of pain and inflammatory neuromuscular and postural functions, comprising at least one support (1) and a mixture (2) provided by a combination of at least two types of quantum dots, comprising the following: - Graphene quantum dots with fluorescence indicators corresponding to: λex 350 nm; λem 445 nm, FWHM 65 nm, and quantum dots with a quantum yield >65%; - Blue luminescent graphene quantum dots with fluorescence corresponding to: λex 350 nm; λem 445 nm±10 nm, FWHM 75 nm, and quantum dots with a quantum yield ≥20%; - Cyan-luminescent graphene quantum dots with fluorescence indicators corresponding to: λem 475-495nm, FWHM 70nm, and quantum yield >17%; - Aqua-green luminescent graphene quantum dots with fluorescence indicators corresponding to: λex 485nm, λem 530nm±10nm, FWHM 80 nm, and quantum dots with a quantum yield ≥17%. - Perovskite quantum dots coated with oleic acid and oleylamine, with fluorescence indicators corresponding to: quantum dots with λem 480nm; -COOH functionalized CdTe nucleo-quantum dots, showing fluorescence indications corresponding to quantum dots with λem 710 nm and quantum yield ≥15%; - Oleic acid-functionalized CdS / ZnS core-shell quantum dots, showing fluorescence indicators corresponding to: λ max 385 nm; λem 400 nm ± 10 nm, quantum dots with quantum yield > 50%; - Oleic acid-functionalized CdS / ZnS core-shell quantum dots, exhibiting fluorescence indicative of: Quantum dots with a maximum wavelength of 405 nm and a λem of 425 nm ± 10 nm; in, The support (1) is composed of sheet-like elements of a transparent material at a reference wavelength and at the wavelength of radiation emitted by the human body. The first side of the support (1) is adapted to directly contact the skin of a person with a functional impairment or inflammatory disease to be treated, and the concentration is 1 mg / cm³. 2 Up to 100 mg / cm 2 The mixture (2) is placed on the opposite side of the first side of the support (1), or incorporated into or dispersed into the sheet element itself, and is capable of emitting photons at a reference wavelength with an intensity of 0.1 mW / cm when stimulated by at least one of infrared, visible, or ultraviolet electromagnetic radiation. 2 and 0.5mW / cm 2 The reference wavelength is between 280 nm and 740 nm.

2. The treatment device according to claim 1, characterized in that, The strength is 0.2 mW / cm 2 and 0.4mW / cm 2 between.

3. The treatment device according to claim 1, characterized in that, The reference wavelength is between 350 nm and 530 nm.

4. The treatment device according to any one of claims 1 to 3, characterized in that, The support (1) is made of a material that is transparent to the electromagnetic radiation that excites the mixture (2).

5. The treatment device according to any one of claims 1 to 3, characterized in that, The support is made of a plastic material that can connect to the patient's epidermis and is impermeable and inherent to sweat.

6. The treatment device according to any one of claims 1 to 3, characterized in that, The support is made of a flexible material that can connect to the patient's skin and follow its movement and / or deformation without falling off.

7. The treatment device according to claim 6, characterized in that, The support has a thickness between 0.05 mm and 2 mm.

8. The treatment device according to claim 7, characterized in that, The support has a thickness between 0.1 and 1 mm.

9. The treatment device according to any one of claims 1 to 3, characterized in that, The mixture (2) is distributed on the support (1) in a distributed manner, occupying most of the surface of one side of the arrangement, developing the entire surface for high transmission efficiency of the electromagnetic radiation, not blocked by the overlap of the quantum dots, and having a thickness between 0.001 and 1 mm.

10. The treatment device according to any one of claims 1 to 3, characterized in that, The mixture (2) is arranged in discrete regions on the support (1) to concentrate the radiative flux in a defined region so that it is received through the support, and has a thickness of 0.005 to 1 mm.

11. The treatment device according to any one of claims 1 to 3, characterized in that, The support (1) is connected to a second sheet element (4, 5) for protection and restraint, which protects the mixture (2) from external agents or mechanical stresses that could damage the mixture (2).

12. The treatment device according to claim 11, characterized in that, The second sheet element (4, 5) is made of a material that is transparent to infrared electromagnetic radiation, visible electromagnetic radiation or ultraviolet electromagnetic radiation, such that the electromagnetic radiation from the outside and passing through the second sheet element (4, 5) can excite the mixture (2) to emit the target frequency.

13. The treatment device according to claim 11, characterized in that, The second sheet element (4, 5) has an extension equivalent to that of the support (1), and the surface of the second sheet element facing the support (1) is connected and abuts against the support (1) to retain and seal the mixture (2).

14. The treatment device according to claim 11, characterized in that, The second sheet element (4, 5) consists of a transparent protective ink or plastic film that can reduce the thickness of the treatment device and make the treatment device easier to wear.

15. The treatment device according to claim 11, characterized in that, The mixture (2) is diluted in ink to be printed on the side of the support (1) facing the second sheet element (4, 5) or on the side of the second sheet element (4, 5) facing the support (1).

16. The treatment device according to claim 15, characterized in that, The ink is transparent, so that all emitted photons and incoming radiation can reach the mixture with minimal attenuation (2).

17. The treatment device according to any one of claims 1 to 3, characterized in that, The total thickness of the treatment device is kept to a minimum to maintain a high level of elasticity and to adapt to the surface stress of the skin without cracking, breaking, or tearing.

18. The treatment device according to claim 11, characterized in that, The interconnection between the skin and the support (1), and / or the interconnection between the support (1) and the second sheet element (4, 5) is achieved by means of a flexible double-sided adhesive (3).

19. The treatment device according to any one of claims 1 to 3, characterized in that, The treatment device is mostly transparent and is attached to the skin by adhesive force. It is placed near primary and secondary extremities, tendons, muscles, dermatomes, and nerve endings to facilitate neuromuscular and postural readjustment, enabling the examination of any redness on the skin.

20. The treatment device according to any one of claims 1 to 3, characterized in that, The therapeutic device exerts greater activity of the mixture (2) in the following situations: comprising 5% to 80% carbon nanotube ink, 20% to 95% mixture, depending on the type of quantum dots used and the target frequency of the therapeutic radiation, and manages the calibration, relimitation and determination of the amount of photons emitted by the therapeutic device according to the patient's needs and desired stimulation.

Images