Biopsy needles and tissue collection devices

Abstract

The present invention provides a biopsy needle and a tissue collection device that can collect a sufficient amount of biological tissue for a clear pathological diagnosis with a simple structure and simple operation. The biopsy needle tube (54) inserted into the forceps channel of an endoscope comprises: a puncture portion (56) provided at the front end (55) of the tube (54) and having at least one blade tip (62); a slit (58) extending from the front end opening (50) of the tube (54) toward the base end opening (52); and a tissue removal cutter (60) provided at the base end (58C) of the slit (58) and tapering from the base end (58C) of the slit (58) toward the front end of the slit (58).

Description

Technical Field

[0001] The present invention relates to a biopsy needle and a tissue collecting device, and in particular to a biopsy needle and a tissue collecting device for collecting biological tissue. Background Art

[0002] In recent years, diagnostics have been conducted by inserting a needle into a body cavity through the insertion channel of an ultrasonic endoscope. Under observation of ultrasonic tomographic images using the ultrasonic endoscope, the needle is guided to the observation site and inserted into the diseased tissue, thereby clarifying the pathology by collecting biological tissue.

[0003] As a known tissue sampling device for performing such a definitive pathological diagnosis, for example, the device disclosed in Patent Document 1 is provided. The tissue sampling device of Patent Document 1 comprises: a sheath having flexibility for freely inserting through an insertion channel of an endoscope treatment instrument; a needle tube freely inserted into the interior of the sheath for puncturing living tissue; an operating portion coupled to the proximal end of the sheath for operating the advancement and retraction of the needle tube; and a syringe connected to the operating portion for applying negative pressure to the needle tube.

[0004] Furthermore, the needle tube disclosed in Patent Document 1 has a slit extending from the front end opening toward the base end side, and a step difference is formed between the first edge and the second edge by configuring the curvature radius of the first edge portion provided on both sides of the slit to be larger than the curvature radius of the second edge portion.

[0005] According to the tissue collection device disclosed in Patent Document 1, after the needle tube is inserted into the diseased tissue, the needle tube is rotated to draw tissue from the gap between the steps toward the distal end of the tube. The needle tube is then further rotated to remove the drawn tissue through the edge of the slit. This allows for the collection of a sufficient amount of tissue for a definitive pathological diagnosis.

[0006] Previous technical literature

[0007] Patent Literature

[0008] Patent Document 1: International Publication No. 2014 / 112518 Summary of the Invention

[0009] Technical issues to be solved by the invention

[0010] However, the needle tube of Patent Document 1 (hereinafter referred to as a biopsy needle) has a complex structure including a first edge portion and a second edge portion having different curvature radii. Therefore, it is difficult to manufacture a biopsy needle having a small outer diameter, for example, 3 mm or less.

[0011] Furthermore, according to the tissue collection device of Patent Document 1, when a biological tissue is taken in and excised by a biopsy needle, the biopsy needle is rotated about its axis. However, in this case, the operating portion must be rotated together with the syringe, which may place a burden on the operator.

[0012] The present invention has been made in view of such circumstances, and an object thereof is to provide a biopsy needle and a tissue sampling device that can collect a sufficient amount of living tissue for a clear pathological diagnosis with a simple structure and simple operation.

[0013] Means for solving technical problems

[0014] In order to achieve the purpose of the present invention, the biopsy needle involved in the present invention is a biopsy needle for insertion into the forceps channel of an endoscope, which comprises: a hollow tube having a front end opening and a base end opening, and the front end opening and the base end opening are connected to each other, the tube having: a puncture portion, which is provided at the front end of the tube and has at least one blade tip point; a slit, which extends from the front end opening toward the base end opening side; and a tissue resection blade, which is provided at the base end of the slit and is formed to be tapered from the base end of the slit toward the front end of the slit.

[0015] Furthermore, in one aspect of the biopsy needle according to the present invention, the tissue excision blade preferably has at least one inclined blade surface inclined from the base end of the slit toward the front end of the slit so as to approach the central axis of the tube.

[0016] Furthermore, in one aspect of the biopsy needle according to the present invention, preferably, a sharp blade is formed on the inclined blade surface, and the blade is formed at a position that does not protrude from the outer peripheral surface of the tube toward the outside of the tube.

[0017] Furthermore, in the biopsy needle according to the present invention, when the tube is viewed from the axial direction of the tube, it is preferable that at least one blade tip point and the slit are arranged to face each other in the radial direction of the tube.

[0018] Furthermore, in the biopsy needle according to the present invention, it is preferable that the at least one blade tip point includes a first blade tip point formed on the distal end side of the tube material relative to the slit in the axial direction of the tube material.

[0019] Furthermore, the puncture portion of the biopsy needle involved in the present invention preferably has a first blade tip point, a second blade tip point and a third blade tip point, and the first blade tip point, the second blade tip point and the third blade tip point are respectively formed on the inner circumferential surface of the tube. When the tube is observed from a direction perpendicular to the axial direction of the tube, the first blade tip point is formed closer to the front end side of the tube than the second blade tip point and the third blade tip point. When the tube is observed from the axial direction of the tube, the first blade tip point is arranged opposite to the slit in the radial direction of the tube, and the second blade tip point and the third blade tip point are arranged opposite to each other with the slit separated by the slit.

[0020] Furthermore, in the biopsy needle involved in the present invention, the front end portion of the tube preferably has: a first blade surface, which connects the outer peripheral surface of the tube and the first blade tip point and the second blade tip point, and has a normal line including a component facing the radial outside of the tube and a component facing the front end side of the tube; and a second blade surface, which connects the outer peripheral surface of the tube and the first blade tip point and the third blade tip point, and has a normal line including a component facing the radial outside of the tube and a component facing the front end side of the tube.

[0021] Furthermore, in the biopsy needle according to the present invention, it is preferable that at least one cutting edge point is formed on the inner peripheral surface of the tube.

[0022] Furthermore, in the biopsy needle according to the present invention, the length from the first blade tip to the front end of the tissue resection blade in the axial direction of the tube is preferably 0.5 mm or more and 25.0 mm or less.

[0023] Furthermore, in the biopsy needle according to the present invention, the width of the slit in the circumferential direction of the tube is preferably smaller than the inner diameter of the tube.

[0024] Furthermore, in the biopsy needle according to the present invention, the outer diameter of the tube is preferably 0.3 mm or more and 3.0 mm or less.

[0025] Furthermore, in the biopsy needle according to the present invention, the inner diameter of the tube is preferably not less than 0.1 mm and not more than 2.5 mm.

[0026] Furthermore, in the biopsy needle according to the present invention, it is preferable that an echo marker capable of visually indicating the position of the tube on an ultrasonic image is provided on the outer peripheral surface of the tube.

[0027] Furthermore, in the biopsy needle according to the present invention, the echogenic marker is preferably provided only around the base end including the slit.

[0028] Furthermore, in the biopsy needle according to the present invention, the echo marker is preferably provided in a region on the distal end side of the tube material starting from the periphery of the proximal end including the slit.

[0029] Furthermore, in the biopsy needle according to the present invention, the echo marker is preferably provided in a region on the proximal end side of the tube material starting from the periphery of the proximal end including the slit.

[0030] Furthermore, in the biopsy needle according to the present invention, the echo marker is preferably configured in a concave-convex shape.

[0031] Furthermore, in the biopsy needle according to the present invention, the tube material is preferably made of stainless steel, nickel-titanium alloy, nickel-chromium alloy, or cobalt-chromium alloy.

[0032] To achieve the object of the present invention, the tissue sampling device according to the present invention includes the biopsy needle of the present invention and a suction member that communicates with the proximal opening of the biopsy needle to create a negative pressure inside the biopsy needle.

[0033] Effects of the Invention

[0034] According to the present invention, a sufficient amount of biological tissue for a clear pathological diagnosis can be collected with a simple structure and simple operation. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 This is a cross-sectional view of the main parts showing a state in which the tissue sampling device according to one embodiment of the present invention is incorporated into an ultrasonic endoscope.

[0036] Figure 2 It is a cross-sectional view showing the overall structure of the tissue collection device.

[0037] Figure 3 This is a cross-sectional view of the insertion portion where the biopsy needle protrudes from the front end opening of the sheath.

[0038] Figure 4 This is a cross-sectional view of the insertion portion of the biopsy needle embedded in the sheath.

[0039] Figure 5 This is an enlarged perspective view showing the structure of the distal end portion of a tube constituting the tissue sampling device.

[0040] Figure 6 This is an enlarged perspective view showing the structure of the distal end portion of a tube constituting the tissue sampling device.

[0041] Figure 7 This is a front view showing the structure of the front end portion of the tube constituting the tissue sampling device.

[0042] Figure 8 This is an explanatory diagram showing a method of collecting living tissue using a tissue collecting device.

[0043] Figure 9 It is a perspective view showing the front end portion of a pipe material according to a first modification.

[0044] Figure 10 It is a perspective view showing the front end portion of a pipe material according to a second modification.

[0045] Figure 11 It is a perspective view showing the front end portion of a pipe material according to a third modified example.

[0046] Figure 12 It is a perspective view showing the front end portion of a pipe material according to a fourth modified example.

[0047] Figure 13It is a perspective view showing the front end portion of a pipe material according to a fifth modification.

[0048] Figure 14 It is a perspective view showing the front end portion of a pipe material according to a sixth modification.

[0049] Figure 15 It is a perspective view showing the front end portion of a pipe material according to a seventh modification.

[0050] Figure 16 It is a perspective view showing the front end portion of a pipe material according to an eighth modification.

[0051] Figure 17 This is a perspective view showing a first embodiment of the echo marker.

[0052] Figure 18 This is a perspective view showing a second embodiment of the echo marker.

[0053] Figure 19 This is a perspective view showing the third embodiment of the echo marker.

[0054] Figure 20 This is a perspective view showing the fourth embodiment of the echo marker. DETAILED DESCRIPTION

[0055] Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.

[0056] In the description of the puncture tissue sampling device to which the present invention is applied, a structure has been described in which the device is inserted into a body cavity via a treatment instrument insertion channel formed in an ultrasonic endoscope that performs electronic convex scanning. However, the guide mechanism of the tissue sampling device can also be a treatment instrument insertion channel of an ultrasonic endoscope using other scanning methods, or a conventional endoscope without an ultrasonic diagnostic mechanism, as well as a trocar. When inserted into the trocar, the entire device can be constructed of rigid components.

[0057] First, in Figure 1 The figure shows the structure of the distal end portion of an ultrasonic endoscope used to guide a tissue sampling device. Reference numeral 10 denotes the insertion portion into the body cavity. This insertion portion 10 comprises a distal end body 12 connected to the distal end of a curved portion 11. Within distal end body 12, an endoscopic observation section 13 is provided at the proximal end and an ultrasonic observation section 14 is provided at the distal end. The endoscopic observation section 13 is provided at an inclined portion 12a at the proximal end of distal end body 12 and is configured to orient the observation field obliquely forward.

[0058] exist Figure 1, an illumination mechanism 15 including a light guide constituting the endoscope observation section 13 is shown, and an observation mechanism is provided adjacent to the illumination mechanism 15, but the observation mechanism is omitted from the illustration. Alternatively, a solid-state imaging element or an image guide may be used as the observation mechanism.

[0059] The ultrasonic observation section 14 includes an ultrasonic transducer unit 16 mounted in an opening 12b provided at the distal end of the distal end body 12. The ultrasonic transducer unit 16 performs electronic convex scanning and is composed of a plurality of long ultrasonic transducers 17 arranged in an arc shape.

[0060] A treatment instrument outlet 18 is formed between the endoscope observation section 13 and the ultrasonic observation section 14. The treatment instrument outlet 18 is a passage having a predetermined inner diameter that penetrates the distal end body 12. A connecting tube 19 is connected to the treatment instrument outlet 18. The connecting tube 19 is bent at a predetermined angle, and a flexible tubing 20 is connected to its base end. Thus, the treatment instrument outlet 18, the connecting tube 19, and the flexible tubing 20 constitute a treatment instrument insertion channel 21. The treatment instrument outlet 18 extends obliquely forward relative to the axis of the insertion section 10, the flexible tubing 20 extends along the axis of the insertion section 10, and the connecting tube 19 is bent at a predetermined angle in the middle.

[0061] Reference numeral 30 denotes a tissue sampling device according to an embodiment. The tissue sampling device 30 is inserted into the treatment instrument insertion channel 21 and can be extended or retracted from the treatment instrument lead-out portion 18. The distal end portion body 12 can then be brought into contact with the inner wall s of the body cavity. The ultrasonic observation portion 14 brings the living tissue sampling site T into the ultrasonic observation field of view. The distal end portion of the tissue sampling device 30 is then inserted through the treatment instrument lead-out portion 18 into the inner wall S of the body cavity. After being guided to the tissue sampling site T, the living tissue is sampled.

[0062] Figure 2 : is a cross-sectional view showing the overall structure of the tissue collection device 30. Figure 2 As can be seen, the tissue collecting device 30 is composed of an insertion portion 31 and an operating portion 32, and a syringe 33 is detachably connected to the proximal end of the operating portion 32. The syringe 33 is an example of a suction member.

[0063] The insertion portion 31 is at least longer than the total length of the treatment instrument insertion channel 21. Figure 3 and Figure 4 As shown, it is composed of a double-tube component. That is, the insertion portion 31 is composed of a sheath 34 and a biopsy needle 35 inserted into the inside of the sheath 34 starting from the outermost peripheral side. Figure 3 34 is a cross-sectional view of the insertion portion 31 showing a state in which the biopsy needle 35 protrudes from the front end opening 34A of the sheath 34. Figure 4 It is a cross-sectional view of the insertion portion 31 showing a state in which the biopsy needle 35 is embedded in the sheath 34 .

[0064] The sheath 34 is inserted through the treatment instrument insertion channel 21 of the endoscope and forms the outer shell of the insertion portion 31. The sheath 34 is formed of a flexible, cylindrical member, such as a resin member such as polyethersulfone, Teflon (registered trademark), or polyetheretherketone (PEEK). Alternatively, the sheath 34 may be formed of a sealed coil or the like.

[0065] The biopsy needle 35 is inserted into the living tissue to collect the diseased tissue and is freely inserted into the sheath 34. The detailed structure of the biopsy needle 35 will be described later. The biopsy needle 35 has a tube 54. The tube 54 has a front end opening 50 and a base end opening 52 (see FIG. Figure 2 ), and the front end opening 50 and the base end opening 52 are connected. Figure 3 and Figure 4 As shown, a puncture portion 56 , a slit 58 and a tissue removal blade 60 are provided at the front end portion 55 of the tube 54 .

[0066] Since the aforementioned tube 54 is inserted into the body, it must be hard. Furthermore, since the tube 54 is inserted into the interior of the treatment instrument insertion channel 21, it must be flexible in the bending direction in order to pass through the curved connecting tube 19 and to be able to be smoothly inserted even when the corner portion 11 is bent. Therefore, the tube 54 is made of thin-diameter and flexible stainless steel, nickel-titanium alloy, nickel-chromium alloy, or cobalt-chromium alloy. Stainless steel is not easy to rust and nickel-titanium alloy is a superelastic alloy, so even if it is inserted into the curved connecting tube 19, it is not easy to produce bending marks. In addition, nickel-chromium alloy and cobalt-chromium alloy have high hardness and can easily penetrate the biological tissue collection site T. In addition, the biopsy needle 35 can also be formed of a hard tube to form the front end portion 55 including at least the puncture portion 56, and the parts other than the front end portion 55 can be formed of a flexible soft tube.

[0067] The pipe 54 is inserted into the sheath 34 so as to be able to move forward and backward. Figure 4 ), and a working position ( Figure 3 position) to move.

[0068] Therefore, the base end portion of the tube 54 is connected to the operating portion 32, and by operating the operating portion 32, the tube 54 extends from or retracts the front end opening 34A of the sheath 34. As a specific structure of the operating portion 32, Figure 2 shown.

[0069] like Figure 2 As shown, the operating portion 32 includes a Luer lock operating portion 39 , a sheath position operating portion 40 , a tube position operating portion 41 , and a stopper ring 42 . Furthermore, a stylet 36 is inserted into the interior of the tube 54 .

[0070] The Luer lock operating portion 39 has a Luer lock portion 39A at its distal end. This Luer lock portion 39A is designed to be secured to the treatment instrument inlet (not shown) of the ultrasonic endoscope and is, for example, removably connected to a pair of Luer locks present at the treatment instrument inlet. The Luer lock operating portion 39 is inserted through a hole in the sheath position operating portion 40. The Luer lock operating portion 39 and the sheath position operating portion 40 are mounted so as to be relatively slidable along the axis P of the operating portion 32. The Luer lock operating portion 39 and the sheath position operating portion 40 are secured together by screws 43 that are threaded from the outer circumference of the sheath position operating portion 40 toward the outer circumference of the Luer lock operating portion 39.

[0071] Furthermore, a stop ring 42 is provided on the outer circumference of the sheath position operating portion 40 so as to be slidable along the axis P. The stop ring 42 is secured by a screw 44 threaded from the outer circumference of the stop ring 42 toward the outer circumference of the sheath position operating portion 40. The sheath position operating portion 40 is inserted through the hole of the pipe position operating portion 41, and the sheath position operating portion 40 and the pipe position operating portion 41 are mounted so as to be slidable relative to each other along the axis P. The relative position of the sheath position operating portion 40 and the pipe position operating portion 41 in the direction of the axis P is determined by the contact between the front end surface 41A of the pipe position operating portion 41 and the stop ring 42.

[0072] With respect to the operating portion 32 having the above-described structure, the proximal end of the sheath 34 is inserted through the hole of the luer lock operating portion 39 into the hole of the sheath position operating portion 40 and fixed to the proximal end of the sheath position operating portion 40. Consequently, the proximal end opening 34B of the sheath 34 opens at the proximal end of the sheath position operating portion 40. Furthermore, the proximal end of the tube 54 is inserted through the proximal end opening 34B of the sheath 34 into the hole of the tube position operating portion 41 and fixed to the proximal end of the tube position operating portion 41. Consequently, the proximal end opening 52 of the tube 54 opens at the proximal end of the tube position operating portion 41. Furthermore, a luer lock 45 is provided at the proximal end of the tube position operating portion 41, communicating with the proximal end opening 52. A stylet 36 is provided between the luer lock 45 and the position protruding from the tube distal end opening 50. The stylet 36 serves the following functions: protecting the blade tips 62, 64, and 66, protecting the sheath 34 from the blade tips 62, 64, and 66, and preventing foreign matter from entering the tubing 54. When the stylet 36 protrudes from the tubing distal end opening 50, and the sheath 34 is curved as a portion of a circular arc, the distal end surface of the stylet 36 and the outer circumferential surface of the tubing distal end opening contact the inner surface of the sheath 34. Furthermore, the distal end surface of the stylet 36 is pressed against the inner surface of the sheath 34, causing the tubing distal end opening 50 to retreat to a position away from the inner surface of the sheath 34. When the stylet 36 is completely removed from the Luer lock 45 toward the proximal end, the syringe 33, which has a pair of Luer locks for suction and liquid delivery, can be attached and detached from the Luer lock 45.

[0073] Then, Figure 2 An example of use of the tissue collection device 30 shown will be described.

[0074] First, when the sheath 34 through which the tube 54 is inserted is inserted from the treatment instrument introduction port of the ultrasonic endoscope, Figure 1 When the treatment instrument shown is inserted through the channel 21, for example, when the front end of the sheath 34 is located Figure 1 When the luer lock portion 39A of the luer lock operating portion 39 is near the front end of the treatment instrument outlet portion 18, the luer lock portion 39A of the luer lock operating portion 39 is fixed to the pair of luer locks of the treatment instrument introduction port.

[0075] Next, the screw 43 is loosened, and the sheath position operating portion 40 is slid relative to the Luer lock operating portion 39 along the axis P in the direction of arrow Q. This causes the distal end of the sheath 34 to protrude from the treatment instrument outlet 18. The sliding position of the sheath position operating portion 40 is then adjusted, and when the protruding length of the sheath 34 reaches an appropriate length, the sheath position operating portion 40 is fixed to the Luer lock operating portion 39 using the screw 43.

[0076] Next, the screw 44 is loosened, allowing the stop ring 42 to slide relative to the sheath position operating unit 40 along the axis P, thereby adjusting the position of the stop ring 42 relative to the sheath position operating unit 40. In other words, the protrusion length of the tube 54 from the front end of the sheath 34 is adjusted. This adjustment can be performed, for example, by observing the scale printed on the outer circumference of the sheath position operating unit 40. The stop ring 42 is then secured to the sheath position operating unit 40 using the screw 44.

[0077] Next, the stylet 36 protruding from the distal end opening 50 is slightly pulled out toward the proximal end and embedded approximately 5 to 10 mm from the distal end opening 50 of the tube.

[0078] Next, the tube position operating portion 41 is slid relative to the sheath position operating portion 40 along the axis P in the direction of the arrow Q. Due to this sliding action, the front end portion 55 of the tube 54 protrudes from the front end opening 34A of the sheath 34. Then, when the front end surface 41A of the tube position operating portion 41 abuts against the stop ring 42, the front end portion 55 of the tube 54 penetrates the tissue collection site T (refer to FIG. Figure 1 ).

[0079] Next, the stylet 36 is pulled out from the Luer lock 45 and completely removed. After that, the syringe 33 can be attached to the Luer lock 45 to perform aspiration. The above is an example of how the tissue collection device 30 is used.

[0080] Furthermore, the tube 54 also functions as a fluid passage. This fluid passage functions as a suction passage for applying negative pressure and a passage for pumping physiological saline solution to discharge the collected biological tissue inside the tube 54.

[0081] Next, the structure of the front end portion 55 of the pipe 54 will be described.

[0082] Figure 5 It is an enlarged perspective view showing the structure of the front end portion 55 of the pipe 54 , and is a perspective view of one side surface of the front end portion 55 as viewed from the front end side of the pipe 54 . Figure 6 This is a perspective view of another side surface of the front end portion 55 as viewed from the front end side of the pipe 54. Figure 7 This is a front view of the front end portion 55 as viewed from the front end side of the pipe 54 .

[0083] Hereinafter, when describing the structure of the front end portion 55 of the pipe 54, a three-dimensional orthogonal coordinate system of the X axis, the Y axis, and the Z axis will be used for description. Figure 2) When observing the distal end portion 55 of the tube 54 and oriented with the slit 58 upward, the upward direction is referred to as the Z(+) direction, and the opposite downward direction is referred to as the Z(-) direction. Furthermore, the rightward direction at this time is referred to as the X(+) direction, and the leftward direction is referred to as the X(-) direction. Furthermore, the direction of the distal end side at this time is referred to as the Y(+) direction, and the direction of the proximal end side is referred to as the Y(-) direction.

[0084] like Figures 5 to 7 As shown, the distal end portion 55 of the tube 54 has the aforementioned puncture portion 56 , slit 58 , and tissue resection blade 60 .

[0085] like Figure 5 As shown, the slit 58 is formed from the front end opening 50 toward the base end opening 52 (refer to Figure 2 The slit 58 is a straight, elongated through hole extending in the Y(-) direction on the distal end 55 side. When collecting tissue, it serves as an inlet for taking a large amount of living tissue from the side surface of the distal end 55 into the interior of the tube 54. The slit 58 is formed by the gap between a pair of wall portions 58A and 58B that protrude from each other in the X direction and extend in the Y direction.

[0086] The tissue removal blade 60 is disposed at the base end 58C of the slit 58. The tissue removal blade 60 is formed to taper from the base end 58C toward the distal end (Y(+) side) of the slit 58. Furthermore, the tissue removal blade 60 has an inclined blade surface 60B that slopes toward the central axis 54C of the tube 54 from the base end 58C of the slit 58 toward the distal end (Y(+) side). A sharp blade 60A is formed on the inner circumferential surface 54A of the tube 54, facing the distal end (Y(+) side) of the slit 58. By disposing this tissue removal blade 60 at the base end 58C of the slit 58, biological tissue introduced into the distal end portion 55 can be removed through the slit 58 by manipulating the tube 54 in the Y(+) direction, i.e., in the same direction as the puncture direction of the tube 54 into the biological tissue collection site T. Furthermore, since the tissue excision cutter 60 only needs to be formed into the aforementioned tapered tip, the blade 60A does not necessarily need to be sharp, and may be a blade thin enough to function as a cutter.

[0087] When the tube 54 moves in the Y(+) direction, the puncture portion 56 is formed from the inner wall S of the body cavity (refer to Figure 1 ) pierce the tissue collection site T (reference Figure 1) portion, and serves to hold the tissue collection site T. The puncture portion 56 of this embodiment includes, as an example, a blade tip 62, a blade tip 64, and a blade tip 66. These blade tips 62, 64, and 66 are each formed so as to gradually taper and sharpen toward the Y(+) direction. Thus, by constituting the puncture portion 56 with multiple blade tips 62, 64, and 66, the tissue collection site T can be securely held within the tube 54, preventing it from escaping outside the tube 54. Blade tip 62 is an example of a first blade tip, blade tip 64 is an example of a second blade tip, and blade tip 66 is an example of a third blade tip.

[0088] The blade tips 62, 64, and 66 are each formed on the inner circumferential surface 54A of the tube 54. The inner circumferential surface 54A is a surface (ZX plane) perpendicular to the axial direction (Y direction) of the tube 54, with its normal direction oriented toward the central axis 54C of the tube 54. By forming the blade tips 62, 64, and 66 on the inner circumferential surface 54A, the blade tips 62, 64, and 66 overlap with the inner circumferential surface 54A when viewed from the axial direction (Y direction) of the tube 54. Consequently, when the tube 54 is inserted or removed from the sheath 34, the blade tips 62, 64, and 66 do not contact the inner surface of the sheath 34, thereby preventing damage to the sheath 34.

[0089] Furthermore, when the tube 54 is viewed from a direction (X direction) perpendicular to the axial direction (Y direction) of the tube 54, the blade tip 62 is formed closer to the front end of the tube 54 than the blade tip points 64 and 66. Furthermore, when the tube 54 is viewed from the axial direction (Y direction), the blade tip 62 is disposed opposite the slit 58 in the radial direction (Z direction) of the tube 54, while the blade tip 64 and the blade tip 66 are disposed opposite each other in the X direction with the slit 58 interposed therebetween. Furthermore, when the tube 54 is viewed from a direction (X direction) perpendicular to the axial direction (Y direction) of the tube 54, the blade tip 64 and the blade tip 66 are formed at the same position in the axial direction (Y direction) of the tube 54. However, this is merely an example, and the blade tip 64 and the blade tip 66 may be formed at positions offset from each other in the axial direction (Y direction) of the tube 54.

[0090] By forming such blade tip points 62 , 64 , 66 at the front end portion 55 , two blade surfaces 68 , 70 are formed at the front end portion 55 of the tube 54 .

[0091] That is, Figure 5As shown, the blade surface 68 is formed as a surface connecting the outer peripheral surface 54B of the tube 54, the blade tip 62, and the blade tip 64. This blade surface 68 has a normal line including a component facing outward in the radial direction (X(-) direction) of the tube 54 and a component facing the front end (Y(+)) side of the tube 54. By forming this blade surface 68, a sharp blade 68A is formed at the intersection of the blade surface 68 and the inner peripheral surface 54A. Note that this blade surface 68 is an example of a first blade surface.

[0092] like Figure 6 As shown, the blade surface 70 is formed as a surface connecting the outer peripheral surface 54B of the tube 54 and the blade tip points 62 and 66. This blade surface 70 has a normal line including a component facing the outer side of the radial direction (X(+) direction) of the tube 54 and a component facing the front end (Y(+)) side of the tube 54. By forming such a blade surface 70, a sharp blade 70A is formed at the intersection of the blade surface 70 and the inner peripheral surface 54A. In addition, this blade surface 70 is an example of a second blade surface.

[0093] The above is the structure of the front end portion 55 of the pipe 54. Figure 7 As shown, the pipe 54 of the embodiment is configured in a line-symmetrical shape with the Z axis passing through the central axis 54C of the pipe 54 as the axis of symmetry, but the shape is not limited to this and may be configured in an asymmetrical shape.

[0094] The embodiment is configured as described above. Next, an example of a method for collecting living tissue using the tissue collecting device 30 will be described.

[0095] First, if Figure 1 As shown, the distal end portion body 12 of the ultrasonic endoscope is positioned at a predetermined position relative to the inner wall S of the body cavity. In this position, when a tissue sampling site T in the body is captured within the observation field of the ultrasonic transducer unit 16 constituting the ultrasonic observation section 14, the insertion portion 31 of the tissue sampling device 30 is inserted into the treatment instrument insertion channel 21. At this stage, the distal end opening 34A is accommodated in a position where it does not protrude from the distal end of the treatment instrument outlet 18.

[0096] Next, the sheath position operating portion 40 is operated in the direction of arrow Q to cause the distal end opening 34A to protrude from the distal end of the treatment instrument outlet portion 18 , and the position is fixed with the screw 43 at a position suitable for puncture.

[0097] Here, before being inserted into the inner wall S of the body cavity, the distal end portion 55 of the tube 54 in the insertion portion 31 is covered with the sheath 34 (see Figure 4 In this state, if the pipe position operation unit 41 (reference Figure 2 ) Operate in the direction of arrow Q, then Figure 8As shown in the portion 100a of FIG. 3 , the front end portion 55 of the tube 54 protrudes from the front end opening 34A of the sheath 34 in the Y(+) direction. Then, by continuing the protruding action of the tube 54 in the Y(+) direction, as shown in FIG. Figure 8 As shown in the portion 100b of FIG. 1 , the puncture portion 56 of the front end portion 55 is inserted from the inner wall S of the body cavity (reference Figure 1 )Punch into the tissue collection site T.

[0098] at this time, Figure 8 100a, the stylet 36 (reference Figure 2 ) After the front end opening 50 is embedded to about 5mm to 10mm, the front end 55 of the tube is protruded, so that the tip of the blade can be used to pierce the tissue collection site T. Figure 8 After 100b, by making the stylet 36 protrude from the front end opening 50 of the tube again, the stomach wall or other foreign matter mixed in during the insertion can be discharged to the outside of the tube. Thus, only the subject more suitable for pathological diagnosis can be obtained.

[0099] Furthermore, blade tip 62, located most distally among blade tip points 62, 64, and 66, functions as the blade tip that forms the starting point for insertion. Blade tip points 64 and 66, trailing blade tip 62, are then guided by blade surfaces 68 and 70 that precede blade tip points 64 and 66, respectively, as they smoothly penetrate the tissue collection site T from the inner wall S of the body cavity. In this embodiment, the puncture portion 56 is comprised of multiple blade tip points 62, 64, and 66. This allows the inserted tissue collection site T to be securely held within the tubing 54, preventing it from escaping outside the tubing 54. Furthermore, the insertion path of the tubing 54 is captured within the ultrasonic field of view, enabling safe insertion and reliable targeting of the tissue collection site T.

[0100] Then, if Figure 8 As shown in portion 100c of the drawing, as the tube 54 continues to protrude in the Y(+) direction, causing the puncture portion 56 to penetrate the living tissue (e.g., a tumor) at the living tissue collection site T, a portion of the living tissue intrudes through the slit 58 into the interior of the tube 54. Then, in this state, as the tube 54 further protrudes in the Y(+) direction, the living tissue that has intruded into the interior of the tube 54 is removed by the blade 60A of the tissue removal cutter 60, and the removed living tissue is collected into the interior of the tube 54. Thus, a sufficient amount of living tissue for a definitive pathological diagnosis can be collected through the tube 54.

[0101] Furthermore, by applying suction force to the above-mentioned finger operation, a larger biological tissue can be obtained. There are mainly two methods for applying suction force. The first method is to use a syringe 33. Figure 8After 100 b, the stylet 36 is completely withdrawn from the Luer lock 45 toward the proximal end. Then, the syringe 33 is attached to the Luer lock 45. When the interior of the tubing 54 is maintained at a negative pressure by operating the syringe 33, suction is generated in the slit 58, further increasing the amount of living tissue that enters the slit 58. Furthermore, when the tubing 54 is reciprocated within the living tissue while the slit 58 generates suction, the living tissue continuously enters the tubing 54 through the slit 58, thereby enabling more living tissue to be efficiently collected.

[0102] The second suction method is to use the stylet 36. When the stylet 36 is slowly pulled out toward the base end of the Luer lock portion 45, Figure 8 When the pressure is 100c, a slight negative pressure can be applied to the interior of the tube 54. This also enables the acquisition of large biological tissues.

[0103] As described above, after the insertion portion 31 of the tissue collection device 30 collects the biological tissue, the insertion portion 31 is pulled out from the treatment instrument piercing channel 21. In this case, for example, Figure 8 As shown in the portion 100d of FIG. 1 , the tube 54 is moved in the Y(-) direction and the distal end portion 55 of the tube 54 is embedded in the sheath 34 . In this state, the insertion portion 31 can be pulled out of the treatment instrument insertion channel 21 .

[0104] After the insertion portion 31 is removed from the treatment instrument insertion channel 21, a syringe that pumps physiological saline solution, for example, is connected to the Luer lock portion 45 in place of the suction syringe 33. This syringe pumps physiological saline solution into the tubing 54. This allows the collected biological tissue to be transferred to a test tube, etc. Alternatively, the biological tissue inside the tubing can be squeezed out and discharged by reinserting the stylet 36 through the Luer lock portion 45 and protruding it until it reaches the tubing's distal end opening 50.

[0105] As described above, according to the embodiment, a structure in which a tissue removal blade 60 is provided at the base end 58C of the slit 58 in the tube 54 having the puncture portion 56 and the slit 58 is employed. Therefore, a sufficient amount of biological tissue for a definitive pathological diagnosis can be collected with a simple structure. Furthermore, with this structure, biological tissue can be collected by moving the tube 54 in the Y(+) direction (the same direction as the puncture direction of the tube 54 with respect to the biological tissue). Therefore, compared to the tissue collection device of Patent Document 1, which rotates the tube during collection, biological tissue can be collected with a simpler operation.

[0106] Therefore, according to the embodiment, a sufficient amount of biological tissue for a clear pathological diagnosis can be collected with a simple structure and simple operation.

[0107] Furthermore, according to the embodiment, since the blade 60A of the tissue resection tool 60 is formed on the inner peripheral surface 54A of the tube 54, the blade 60A will not pierce or get stuck on the inner peripheral surface of the sheath 34 or the front end body 12, and the tube 54 can be smoothly moved forward and backward relative to the inside of the sheath 34.

[0108] In addition, in the embodiment, the blade 60A is formed on the inner peripheral surface 54A of the tube 54. However, the blade 60A may be formed between the inner peripheral surface 54A and the outer peripheral surface 54B, or on the same surface as the outer peripheral surface 54B. Furthermore, the blade 60A may be formed at a position protruding from the outer peripheral surface 54B toward the outside of the tube 54. However, from the perspective of preventing the aforementioned piercing and jamming, it is preferable to form the blade 60A at a position that does not protrude from the outer peripheral surface 54B of the tube 54.

[0109] Furthermore, in the embodiment, since the tissue resection blade 60 includes the above-described inclined blade surface 60B, the living tissue resected by the blade 60A can be reliably resected from the tissue collection site T by the inclined blade surface 60B.

[0110] Furthermore, in the embodiment, the puncture portion 56 includes multiple blade tip points 62, 64, and 66. This facilitates puncturing the living tissue collection site T and reliably maintains the punctured living tissue collection site T, preventing it from escaping outside the tube 54. Furthermore, while the embodiment illustrates three blade tip points 62, 64, and 66, at least one blade tip point is sufficient. However, from the perspectives of penetration and retention described above, it is preferable to have multiple blade tip points.

[0111] Furthermore, in the embodiment, a configuration is employed in which the blade tip 62, which is furthest from the slit 58 in the Y direction, and the slit 58 are arranged opposite each other in the radial direction (Z direction) of the tube 54. Specifically, after the blade tip 62 is sufficiently penetrated into the living tissue collection site T, the slit 58 is brought into contact with the living tissue, thereby enabling appropriate collection of the living tissue.

[0112] Furthermore, in the embodiment, the cutting edges 68 and 70 are formed on the distal end portion 55 of the tube 54. That is, the inner circumferential surface 54A of the tube 54 always contacts the living tissue collection site T before the outer circumferential surface 54B of the tube 54, thereby enabling appropriate collection of living tissue.

[0113] And, as Figure 3As shown, the length L from the blade tip 62 to the blade 60A of the tissue removal cutter 60 in the axial direction (Y direction) of the tube 54 is preferably 0.5 mm or more and 25.0 mm or less. This ensures that the blade tip 62 reliably forms the starting point for insertion, and facilitates insertion of the entire length of the slit 58 into the living tissue collection site T during finger manipulation, thereby enabling appropriate collection of living tissue.

[0114] And, as Figure 7 As shown, the width B of the slit 58 in the circumferential direction of the tube 54 is preferably smaller than the inner diameter ID (Inner Diameter) of the tube 54. This prevents the living tissue introduced into the distal end portion 55 from escaping to the outside of the distal end portion 55, thereby enabling appropriate collection of the living tissue.

[0115] And, as Figure 7 As shown, the outer diameter OD (Outer Diameter) of the tube 54 is preferably 0.3 mm or more and 3.0 mm or less. This allows the tube 54 to be inserted smoothly into the sheath 34 and reduces the degree of invasion into the patient.

[0116] And, as Figure 7 As shown, the inner diameter ID of the tube 54 is preferably 0.1 mm or more and 2.5 mm or less. This allows a large amount of biological tissue to be taken into the tube 54 while maintaining the strength of the tube 54.

[0117] The biopsy needle and tissue collection device of the present invention have been described in detail above. However, the present invention is not limited to the above examples. Various improvements or modifications can be made without departing from the scope of the present invention. Several modifications are described below. Figures 3 to 7 The same or similar components of the pipe 54 are denoted by the same reference numerals and described below.

[0118] [First Modification]

[0119] exist Figure 9 In the first modification shown, a cutting edge 60C is formed on a cutting edge 60A of a tissue removal blade 60. The cutting edge 60C is formed at the circumferential center of the tube 54 in the cutting edge 60A and is sharpened toward the front end of the slit 58.

[0120] According to the first modification, the blade tip 60C functions as the starting point of penetration of the living tissue that has penetrated into the interior of the tube 54 through the slit 58, and thus the living tissue can be smoothly removed by the blade 60A behind the blade tip 60C. Figure 9The tissue excision blade 60 shown has two inclined blade surfaces 60B and 60B provided continuously on both sides of the blade tip 60C in the X-axis direction, but it is sufficient to have at least one inclined blade surface 60B.

[0121] [Second Modification]

[0122] exist Figure 10 In the second modified example shown, the blade tip point 62 is formed at the same position as the blade tip points 64 and 66 in the axial direction (Y direction) of the tube 54. Figures 6 to 8 The tubing 54 shown is identical.

[0123] According to the second modification, the blade tips 62, 64, and 66 simultaneously penetrate the living tissue collection site T. Figures 6 to 8 Similarly, the tube 54 shown can also reliably hold the inserted tissue collection site T inside the tube 54 and prevent it from escaping outside the tube 54. The position of the blade tip 62 is not limited to the above position. As long as the tissue collection site T can be prevented from escaping outside the tube 54, the blade tip 62 can be formed closer to the base end of the tube 54 than the blade tips 64 and 66.

[0124] [Third Modification]

[0125] exist Figure 11 In the third modified example shown, the width B1 of the slit 58 is formed to be larger than Figure 7 The width B shown in FIG. Moreover, the width B1 is formed to be smaller than the inner diameter ID of the tube 54 (refer to FIG. Figure 7 ).

[0126] According to the third modification, since the width B1 of the slit 58 is large, more living tissue can be allowed to intrude into the interior of the distal end portion 55 .

[0127] [Fourth Modification]

[0128] exist Figure 12 In the fourth modification shown, the width B2 of the slit 58 is formed to be smaller than Figure 7 The width B shown in FIG. Moreover, the width B2 is formed to be smaller than the inner diameter ID of the tube 54 (refer to FIG. Figure 7 ).

[0129] According to the fourth modification, when the syringe 33 is operated, a suction force greater than the width B is generated in the slit 58 , and therefore a sufficient amount of living tissue can be allowed to intrude into the interior of the distal end portion 55 .

[0130] [Fifth Modification]

[0131] exist Figure 13In the fifth modified example shown, only the front end portion 55 is formed with Figures 5 to 7 The blade tip 62 is formed on the most distal end side of the three blade tip points 62, 64, and 66. As described above, the blade tip 62 is arranged to face the slit 58 in the radial direction of the tube 54.

[0132] According to the fifth modification, when the blade tip 62 is inserted into the tissue sampling site T, the tissue sampling site T can be held by the blade tip 62 , and the tissue can be allowed to penetrate into the distal end portion 55 through the slit 58 .

[0133] [Sixth Modification]

[0134] Figure 14 In the sixth modified example shown, two blade tips 72 and 74 are formed at the front end portion 55 of the tube 54. The blade tips 72 and 74 are each formed on an extension line of the inner circumferential surface 54A of the tube 54 in the Y(+) direction. Furthermore, when the tube 54 is viewed from a direction (X direction) perpendicular to the axial direction (Y direction) of the tube 54, the blade tips 72 and 74 are formed at the same position in the axial direction (Y direction) of the tube 54. Furthermore, when the tube 54 is viewed from the axial direction (Y direction), the blade tips 72 and 74 are arranged opposite each other in the radial direction (Z direction) of the tube 54. However, they are not arranged opposite each other with respect to the slit 58, but are formed with a 90-degree phase difference in the circumferential direction.

[0135] According to the sixth modification, when the blade tips 72 and 74 are inserted into the tissue sampling site T, the tissue sampling site T can be securely held by the blade tips 72 and 74 , and the tissue can be allowed to penetrate into the distal end portion 55 through the slit 58 .

[0136] [7th Modification]

[0137] Figure 15 The seventh modification shown is another modification in which a blade tip 67 is provided and the blade tip 67 is not disposed opposite to the slit 58 in the radial direction of the tube 54. Figure 15 200a is a three-dimensional diagram of the pipe 54, Figure 15 200b is a side view of the pipe 54 viewed from the X(-) direction side. Figure 15 200c is a top view of the tube 54 as viewed from the Z(+) direction side.

[0138] According to the seventh modified example, the blade tip point 67 is formed on the front end side of the tube 54 relative to the slit 58 in the axial direction (Y direction) of the tube 54. Furthermore, the blade tip point 67 is formed on the side of the blade tip point 66 relative to the blade tip point 64 in the X direction, and is formed at a position extending from the blade tip point 66 toward the front end side of the tube 54 in the axial direction (Y direction) of the tube 54. Furthermore, the blade tip point 67 is formed on the front end side of the tube 54 relative to the blade tip points 66 and 68.

[0139] According to the seventh modification, the blade tip 67 penetrates the living tissue collection site T before the blade tip 64 and 66. However, since the tissue removal cutter 60 is provided at the base end 58C of the slit 58, Figure 5 The tube 54 shown can similarly collect a sufficient amount of biological tissue for a clear pathological diagnosis with a simple structure.

[0140] [Variation 8]

[0141] exist Figure 16 In the eighth modification shown, the tissue removal blade 60 has an inclined blade surface 60D that is inclined away from the central axis 54C of the tube 54 from the base end 58C of the slit 58 toward the front end of the slit 58. Furthermore, the blade 60A is formed at a position that protrudes from the outer peripheral surface 54B of the tube 54 toward the outside of the tube 54.

[0142] According to the eighth modification, the biological tissue that has intruded into the interior of the distal end portion 55 through the slit 58 is removed by the blade 60A of the tissue removal cutter 60 by the movement of the tube 54 in the Y(+) direction, and is collected from the interior of the distal end portion 55. In this case, the inclined blade surface 60D functions as a guide surface for pushing the removed biological tissue into the interior of the distal end portion 55.

[0143] Next, several methods of the echo marker provided on the outer peripheral surface 54B of the tube 54 will be described. The echo marker is a mark that can visually indicate the position of the tube 54 under an ultrasonic image. By confirming the echo marker under an ultrasonic image, the position of the distal end portion 55 of the tube 54 can be visually confirmed. Figures 3 to 7 The same or similar components of the pipe 54 are denoted by the same reference numerals and described below.

[0144] like Figures 17 to 20 As shown, the echogenic marker 76 provided on the outer peripheral surface 54B of the tube 54 is formed by densely forming a plurality of small-diameter recesses 78 on the outer peripheral surface 54B. Thus, the outer peripheral surface 54B is provided with recesses and projections, which enhance ultrasonic visibility, thereby enabling confirmation of the position of the distal end portion 55 of the tube 54 under ultrasonic imaging.

[0145] [First method]

[0146] First, in Figure 17 In the first embodiment shown, the echo marker 76 is provided only around the base end 58C of the slit 58 .

[0147] According to the first embodiment, by confirming the position of the echo marker 76 on the ultrasonic image, the position of the base end 58C of the slit 58 can be easily confirmed. This makes it easy to confirm whether the total length of the slit 58 has penetrated the living tissue, thereby enabling safe and reliable finger operation.

[0148] [Second method]

[0149] exist Figure 18 In the second embodiment shown, the echo marker 76 is provided in the area on the front end side (Y(+) direction side) of the tube 54, starting from the area around the base end 58C including the slit 58. Specifically, the echo marker 76 is provided in the entire area of ​​the outer peripheral surface 54B of the tube 54 from the above starting point to the blade tip point 62. Figure 18 Although not shown in the figure, the echo mark 76 is formed on the surface extending to the Z(−) side of the blade tip point 62 .

[0150] According to the second embodiment, by confirming the position of the distal end portion of the echo marker 76 on the ultrasonic image, the position of the distal end portion 55 including the blade tip 62 can be easily confirmed. Furthermore, by confirming the position of the proximal end portion of the echo marker 76, the position of the proximal end 58C of the slit 58 can be easily confirmed. This makes it easy to confirm whether the entire length of the slit 58 has penetrated the living tissue, thereby enabling safe and reliable finger manipulation.

[0151] [Third Method]

[0152] exist Figure 19 In the third embodiment shown, the echo marker 76 is provided in the region on the distal end side (Y(+) direction side) of the tube 54, starting from the area around the base end 58C of the slit 58. Specifically, the echo marker 76 is provided over the entire region of the outer peripheral surface 54B of the tube 54, from the aforementioned starting point to the blade tip points 64, 66.

[0153] According to the third embodiment, by confirming the position of the front end portion of the echo marker 76 under the ultrasonic image, the position of the front end portion 55 including the blade tip points 64 and 66 can be easily confirmed, and by confirming the position of the base end portion of the echo marker 76, the position of the base end 58C of the slit 58 can be confirmed, thereby achieving the same effect as the second embodiment.

[0154] [Form 4]

[0155] exist Figure 20 In the fourth embodiment shown, the echo marker 76 is provided in a region on the proximal end side (Y(−) direction side) of the tube 54 , starting from the area around the proximal end 58C of the slit 58 .

[0156] According to the fourth embodiment, the position of the base end 58C of the slit 58 can be confirmed by confirming the position of the tip portion of the echo marker 76 , and thus the same effects as those of the first embodiment can be obtained.

[0157] Figures 17 to 20 The echo markers 76 shown are configured to confirm the position of the base end 58C of the slit 58, in particular, to confirm whether the total length of the slit 58 has penetrated the living tissue. Such echo markers 76 can be provided at Figures 9 to 15 The pipe 54 of the plurality of modified examples is shown.

[0158] Explanation of symbols:

[0159] 10-Insert portion, 11-Angled portion, 12-Front end body, 12a-Inclined portion, 12b-Opening portion, 13-Endoscope observation portion, 14-Ultrasonic observation portion, 15-Illumination mechanism, 16-Ultrasonic transducer unit, 17-Ultrasonic vibrator, 18-Disposal instrument outlet portion, 19-Connecting tube, 20-Flexible tubing, 21-Disposal instrument insertion channel, 30-Tissue collection device, 31-Insert portion, 32-Operating portion, 33-Syringe, 34-Sheath, 34A-Front end opening, 35-Biopsy needle, 36-Style needle, 39-Luer lock operating portion, 39A-Luer lock portion, 40-Sheath position operating portion, 41-Tube position operating portion, 41A-Front end surface, 42-Retaining ring, 43-Screw , 44-screw, 45-Luer lock portion, 50-front end opening portion, 52-base end opening portion, 54-tube, 54A-inner circumference, 54B-outer circumference, 54C-center axis, 55-front end portion, 56-puncture portion, 58-slit, 58A-wall portion, 58B-wall portion, 58C-base end, 60-tissue resection tool, 60A-blade, 60B-inclined blade surface, 60C-blade tip point, 60D-inclined blade surface, 62-blade tip point, 64-blade tip point, 66-blade tip point, 67-blade tip point, 68-blade surface, 68A-blade, 70-blade surface, 70A-blade, 72-blade tip point, 74-blade tip point, 76-echo marker, 78-recess.

Claims

1. A biopsy needle for insertion into an endoscope forceps channel, comprising: A hollow tube having a front end opening and a base end opening, wherein the front end opening and the base end opening are communicated with each other. The pipe has: a puncture portion, which is provided at the front end of the tube and has at least one blade tip; a slit extending linearly from the front end opening toward the base end opening along the axial direction of the tube; and a tissue removal blade, which is provided at the base end of the slit and is formed to be tapered from the base end of the slit toward the front end of the slit; The puncture portion has a first blade tip point, a second blade tip point, and a third blade tip point. When the pipe is viewed from a direction perpendicular to the axial direction of the pipe, the first blade tip is formed closer to the front end of the pipe than the second blade tip and the third blade tip. When the tube is viewed from the axial direction of the tube, the first blade tip is disposed opposite the slit in the radial direction of the tube, and the second blade tip and the third blade tip are disposed opposite each other with the slit interposed therebetween.

2. The biopsy needle according to claim 1, wherein The tissue resection knife has at least one inclined blade surface inclined from a base end of the slit toward a front end of the slit so as to approach a central axis of the tube.

3. The biopsy needle according to claim 2, wherein: A sharp blade is formed on the inclined blade surface and the blade is formed at a position that does not protrude from the outer peripheral surface of the pipe toward the outside of the pipe.

4. The biopsy needle according to any one of claims 1 to 3, wherein: The slit has a pair of wall portions facing each other in a direction perpendicular to the axial direction of the pipe.

5. The biopsy needle according to any one of claims 1 to 3, wherein: The front end portion of the pipe has: a first blade surface connecting the outer peripheral surface of the pipe and the first and second blade tip points, and having a normal line including a component toward the radially outer side of the pipe and a component toward the front end side of the pipe; and The second blade surface connects the outer peripheral surface of the pipe and the first and third blade tip points and has a normal line including a component toward the radially outer side of the pipe and a component toward the front end side of the pipe.

6. The biopsy needle according to any one of claims 1 to 3, wherein: The at least one blade tip point is formed on the inner peripheral surface of the tube.

7. The biopsy needle according to any one of claims 1 to 3, wherein: In the axial direction of the tube, the length from the first blade tip to the front end of the tissue resection blade is not less than 0.5 mm and not more than 25.0 mm.

8. The biopsy needle according to any one of claims 1 to 3, wherein: The width of the slit in the circumferential direction of the tube is smaller than the inner diameter of the tube.

9. The biopsy needle according to any one of claims 1 to 3, wherein: The outer diameter of the tube is greater than or equal to 0.3 mm and less than or equal to 3.0 mm.

10. The biopsy needle according to any one of claims 1 to 3, wherein: The inner diameter of the tube is greater than or equal to 0.1 mm and less than or equal to 2.5 mm.

11. The biopsy needle according to any one of claims 1 to 3, wherein: An echo marker capable of visually indicating the position of the tube on an ultrasonic image is provided on the outer peripheral surface of the tube.

12. The biopsy needle according to claim 11, wherein The echogenic marker is provided only around the base end including the slit.

13. The biopsy needle according to claim 11, wherein The echo marker is provided in a region on the distal end side of the tube, starting from a region around the base end including the slit.

14. The biopsy needle according to claim 11, wherein The echo marker is provided in a region on the proximal end side of the tube, starting from a periphery including the proximal end of the slit.

15. The biopsy needle according to claim 11, wherein The echo mark is formed in a concave and convex shape.

16. The biopsy needle according to any one of claims 1 to 3, wherein: The pipe is made of stainless steel, nickel-titanium alloy, nickel-chromium alloy or cobalt-chromium alloy.

17. A tissue collection device comprising: The biopsy needle according to any one of claims 1 to 16; and The suction member communicates with the base end opening of the biopsy needle to create a negative pressure inside the biopsy needle.

Images