A biochemical analyzer anti-pollution filtration system and control method

Abstract

The present invention relates to the technical field of biomedical and biochemical experiments and medical and health care, and particularly relates to a biochemical analyzer anti-pollution filtration system and a control method. It includes a workbench in a negative pressure environment. The top of the workbench includes a top plate, and above the top plate is the cover plate of the system. A negative pressure generation chamber is formed between the top plate and the cover plate. The negative pressure generation chamber includes an air outlet and an air inlet. It also includes a blower disposed at the air inlet of the negative pressure generation chamber and a filter disposed at the air outlet of the negative pressure generation chamber. The negative pressure generation chamber is used to provide a negative pressure environment for the workbench. The beneficial effects are as follows: The present invention proposes a biochemical analyzer anti-pollution filtration system. By generating negative pressure in the area of the workbench through the negative pressure generation chamber above the workbench, and cooperating with the filtration of the filter screen, the possible pollutants inside are filtered out, ensuring that the entire workbench is not contaminated by aerosols, and also ensuring that the instrument has a smaller effect on external environmental pollution.

Description

Technical Field

[0001] The present invention relates to the technical fields of biological and biochemical experiments and medical and health care, and particularly relates to a pollution prevention and filtration system and a control method for a biochemical analyzer. Background Art

[0002] With the rapid development of fields such as rapid disease detection, gene sequencing, and high-throughput biopharmaceuticals, people need to process a large number of biological samples in a short time. Traditional methods mostly use manual processing, which is costly, time-consuming, and has problems such as high pollution risks when there is a large amount of manual operation participation. With the development of automation control technology, it has become a trend in the development of the biological and biochemical and medical fields to use an automated operation platform for processing biological samples to replace the cumbersome manual labor. Among them, nucleic acid detection, as a conventional molecular biology technology, is widely used in various fields such as disease control, clinical disease diagnosis, blood transfusion safety, forensic identification, environmental microorganism detection, food safety detection, animal husbandry, and molecular biology research. Since the first paper was published in 1985, polymerase chain reaction has been transformed into countless methods and diagnostic analysis methods. Especially for blood genetic diseases, infectious diseases, and genetic background analysis, fluorescence PCR technology has become an indispensable basic technology. However, in the operation of processing nucleic acid samples, there is an aerosol pollution problem that cannot be ignored, which easily leads to false positives in test results. Therefore, developing a pollution prevention system suitable for automated biological sample processing equipment has become an urgent problem to be solved in the field of molecular diagnosis.

[0003] The patent document CN212293545U discloses an anti-pollution and clean system for nucleic acid extraction and purification equipment. By setting a wind guide cover, a fan and a filter sheet outside the equipment shell, when the equipment is working, the fan exhausts air out of the equipment, thus forming a negative pressure chamber between the wind guide cover and the filter sheet, so that air can only enter the isolation chamber from the filter sheets on both sides, ensuring the cleanliness of the nucleic acid extraction area and providing a clean solution to reduce aerosol pollution. However, the designs of the wind guide cover and the isolation chamber lead to a large volume of the equipment, which is not suitable for automated operation platforms such as biochemical analyzers. Moreover, this design does not perform optimization operations such as rectification, which may cause problems such as incomplete pollutant filtration and uneven negative pressure distribution. The patent document CN207130244U discloses a workstation anti-pollution filtration system. By respectively installing an air inlet filter screen and an air outlet filter screen on the left and right side plates of the workstation, and installing an exhaust fan on the air outlet filter screen, when the workstation is running and maintained, the exhaust fan sucks air outwards, so that the whole system forms a closed air circulation path, and pollutants such as residual aerosol in the workstation can be effectively removed after the suction ends. However, this common form of exhaust air cannot meet the overall negative pressure adjustment and cleanliness requirements of the experiment due to the lack of intelligent control. In the negative pressure scheme, it is not necessarily the case that the highest or preset fixed rotation speed can achieve the optimal effect. Because continuously excessive fan rotation speed may cause insufficient adsorption and filtration of pollutants, resulting in additional pollution, and continuously high rotation speed will lead to greater noise, making it impossible for operators or maintenance personnel to output reliable results efficiently and continuously under the originally heavy working conditions. The need to adjust the required negative pressure by users in different scenarios also needs to be met.

[0004] Therefore, how to meet the intelligent anti-pollution control requirements of automated equipment in the fields of biochemistry and medicine such as molecular diagnosis is a technical problem that urgently needs to be solved in this field. Summary of the Invention

[0005] The purpose of the present invention is to provide a biochemical analyzer anti-pollution filtration system and a control method in view of the deficiencies in the prior art.

[0006] To achieve the above purpose, the technical solution provided by the present invention is as follows:

[0007] A biochemical analyzer anti-pollution filtration system, characterized in that: it includes a workbench in a negative pressure environment, the top of the workbench includes a top plate, above the top plate is the cover plate of the system, a negative pressure generation chamber is formed between the top plate and the cover plate, and the negative pressure generation chamber includes an air outlet and an air inlet; it also includes a fan arranged at the air inlet of the negative pressure generation chamber and a filter arranged at the air outlet of the negative pressure generation chamber, and the negative pressure generation chamber is used to provide a negative pressure environment for the workbench.

[0008] Preferably, a preset rectifying channel is included between the air outlet of the fan and the filter, which is used to fully develop the air flow sent by the fan so as to flow into the external environment more evenly through the filter.

[0009] Preferably, it further includes a wind pressure sensor arranged on the top plate of the workbench, and a controller electrically connected to the fan and the wind pressure sensor.

[0010] Preferably, the controller includes a fan speed control unit associated with negative pressure parameters.

[0011] Preferably, the fan speed control unit controls the fan speed based on preset negative pressure parameters and / or the current negative pressure parameters obtained by the wind pressure sensor.

[0012] Preferably, the controller further includes a fault diagnosis unit, which can judge whether the wind pressure sensor is normal through at least one parameter such as current and voltage during the operation of the fan.

[0013] Preferably, the filter is a HEPA high-efficiency filter screen.

[0014] A control method for using the above biochemical analyzer anti-pollution filtration system, characterized in that it includes a preset negative pressure acquisition unit for acquiring preset negative pressure parameters, the controller adjusts the fan speed to a first target speed in a first mode associated with the preset negative pressure parameters, and the wind pressure sensor acquires and outputs the current negative pressure parameters in the workbench.

[0015] Preferably, the first mode is an adaptive adjustment association mode associated with at least one of usage time, cleanliness of the usage environment, and blockage condition of the air outlet.

[0016] Preferably, the current negative pressure parameters acquired by the wind pressure sensor in the workbench can be used as control parameters for adjusting the fan speed, and the controller adjusts the fan to operate at a speed different from the first target speed based on the current negative pressure parameters.

[0017] Compared with the prior art, the present invention has the following advantages:

[0018] 1. The present invention provides a biochemical analyzer anti-pollution filtration system. A negative pressure generation chamber above the workbench generates negative pressure in the area of the workbench. In combination with the filtration of the filter screen, pollutants that may exist inside are filtered out, ensuring that the entire workbench is not contaminated by aerosols and also ensuring that the instrument has a smaller impact on the external environmental pollution. Further, through a preset rectification channel, the airflow passing through the fan fully develops therein to form a relatively stable flow state, so as to ensure that the air outlet of the fan can pass through the filter more evenly. On the one hand, it ensures a higher filtration efficiency, and on the other hand, it also ensures that the optimized design of the flow resistance of the system better conforms to the flow characteristics.

[0019] 2. By setting a cooperating controller and a wind pressure sensor, the present invention can establish the relationship between the negative pressure required in the workbench area and the rotational speed of the fan operation, so as to achieve the effect that the negative pressure inside the instrument can be set according to requirements. Further, this operation relationship mode can establish an adaptive correction relationship with at least one of the instrument usage time, the cleanliness of the usage environment, the blockage condition of the air outlet, etc., ensuring that the instrument can always work in the most efficient control state.

[0020] 3. The cooperating wind pressure sensor can obtain the current negative pressure parameter inside the workbench, and the controller can adjust the fan to operate at a rotational speed different from the first target rotational speed with the current negative pressure parameter, so as to ensure that the instrument can have self-calibrating control instead of always operating in a rigid preset mode. Further, the controller also includes a diagnostic mode that can judge whether the wind pressure sensor can work normally, and the controller can still control the fan to operate normally in the preset mode under the condition of sensor abnormality, ensuring the reliability of the system. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] To understand the present invention more clearly, the present disclosure is further introduced by combining the specification drawings with schematic embodiments. The drawings and embodiments are used for explanation and do not constitute a limitation to the disclosure.

[0022] Figure 1 is a schematic diagram of a biochemical analyzer including an anti-pollution filtration system provided by the present invention Figure 1 ;

[0023] Figure 2 is a schematic diagram of a biochemical analyzer including an anti-pollution filtration system provided by the present invention Figure 2 ;

[0024] Figure 3 is a schematic diagram of the composition of an anti-pollution filtration system provided by the present invention;

[0025] Figure 4 is a schematic diagram of a detachable air outlet structure provided by the present invention;

[0026] Figure 5 It is a schematic diagram of air flow of an anti-pollution filtration system provided by the present invention;

[0027] Figure 6 It is a schematic diagram of the first mode relationship between a preset negative pressure and the operating speed of a fan provided by the present invention;

[0028] Figure 7 It is a schematic diagram of the control flow of the fan speed provided by the present invention;

[0029] Figure 8 It is a schematic diagram of a terminal GUI interaction interface for cooperative use provided by the present invention. Detailed implementation manners

[0030] To make the objectives, technical solutions, and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are some, but not all, of the embodiments of the present application. Usually, the components of the embodiments of the present application described and illustrated in the accompanying drawings here can be arranged and designed in various different configurations.

[0031] Therefore, the following detailed description of the embodiments of the present application provided in the accompanying drawings is not intended to limit the scope of the present application claimed, but merely represents the selected embodiments of the present application. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present application without creative efforts fall within the scope of protection of the present application.

[0032] It should be noted that: similar reference numerals and letters denote similar items in the following drawings. Therefore, once an item is defined in one drawing, it does not need to be further defined and explained in subsequent drawings.

[0033] Embodiment 1

[0034] A biochemical analyzer anti-pollution negative pressure filtration system in this embodiment is applicable to directions such as biological and biochemical experiments, disease diagnosis, etc. For example, it can be a sample processing automation operation platform such as a nucleic acid workstation or a pipetting workstation. Its specific structure is as follows:

[0035] As Figure 1 And Figure 2 shown, it includes a left side plate, a right side plate 2, a front side plate 1, a rear side plate 3, a bottom plate, and a top plate 4. The four side plates surround the working platform to form a working chamber around it. The workbench arranged inside can be a nucleic acid extraction and / or sample pipetting workbench. The top plate 4 is located above the four side plates, so that the working chamber has good airtightness. In this way, when the negative pressure generating chamber at the top works, the entire workbench can be ensured to be in a negative pressure environment.

[0036] To reduce aerosol contamination during the processing of liquid samples, above the top plate 4 of the studio is the cover plate 5 of the instrument. A negative pressure generation chamber is formed between the top plate 4 and the cover plate 5. A certain number of air ducts (not shown in the figure) are provided in the negative pressure generation chamber to connect the external environment and the internal environment of the studio. The air inlet of the air duct faces the working platform inside the workstation, and the air outlet of the air duct faces the external environment of the workstation. When the negative pressure generation chamber works, the air pressure inside the studio is lower than the air pressure of the external environment, thereby dynamically updating the air around the workbench. Even if a small amount of aerosol is generated during the internal operation process, the negative pressure environment makes the air flow from the high-pressure side of the external environment of the studio to the low-pressure side of the studio, thus realizing the replenishment of fresh air on the workbench. The air that may be contaminated is processed by the filter 8 inside the negative pressure generation chamber, achieving the purpose of reducing aerosol contamination in the studio. To ensure the detachable and convenient maintenance of the filter net 8, the air outlet 6 and the instrument cover plate 5 are connected by a detachable structure, such as using screw connection, riveting, clamping, etc. When the air outlet 6 is separated from the instrument cover plate 5, the filter net 8 can be conveniently removed from the notch of the cover plate 5 for replacement or maintenance.

[0037] Figure 3 The anti-pollution filtration system of the biochemical analyzer also includes a blower 7 provided at the air inlet of the negative pressure generation chamber. The blower 7 is fixed to the top plate 4 by screws. The number of blowers 7 can be set according to the volume of the workstation and experimental requirements. To maintain a relatively good negative pressure environment, in this embodiment, three air ducts are equidistantly arranged in the negative pressure chamber, and a blower 7 is respectively provided at the air inlet of each air duct. Of course, the three independent blowers provided in the present invention to form three side-by-side air ducts can ensure higher working reliability of the system. When one of the blowers fails, the other blowers can operate normally or increase the rotation speed to ensure the basic stability of the negative pressure environment on the workbench. At the same time, the controller can use the working parameters such as the working current and voltage of the abnormal motor to give a determination of the blower failure and further give an alarm message, which can inform the user of the fault content and also ensure that the ongoing work will not be interrupted or stopped. Here, to achieve the effect of exhausting air out of the workstation to form a negative pressure environment in the studio, in this embodiment, the blower 7 is selected as a centrifugal blower. Under the action of centrifugal force, the gas is thrown out and changes its flow direction (for example, a centrifugal blower with an air inlet arranged in the center and an air outlet arranged tangentially in the circumference can be selected). Air is discharged from the air inlet of the negative pressure chamber. The air realizes energy conversion between the impeller and the volute, so that the air obtains higher kinetic energy and has a greater static pressure head, and is discharged to the environment through the filter 8. While the external fresh air can be supplemented into the inside of the workbench through the gaps everywhere on the instrument under the action of the internal and external pressure difference. In this way, a whole dynamic balance appears, ensuring that the instrument workbench can always be in a negative pressure state during work, thereby realizing that the operation on the workbench can avoid the risk of aerosol contamination to the greatest extent.

[0038] In order to effectively filter pollutants such as aerosols and harmful particles generated during experiments in the working chamber during the exhaust process of the fan 7, a high-efficiency filter can also be provided at the air outlet of the negative pressure chamber to avoid air pollution. In this embodiment, a HEPA high-efficiency filter screen 8 is used. The HEPA high-efficiency filter screen 8 is fixed to the top plate 4 by screws. Of course, it can also be detachably arranged in other ways. The filter screen can be strengthened with a single-sided or double-sided metal mesh. Of course, it can also be fixed by setting metal strips, etc. to ensure high-efficiency filtering effect. The HEPA high-efficiency filter screen 8 refers to a high-efficiency filter screen that complies with GB / T 13554-2008 "High-Efficiency Air Filters", GB / T 14295-2008 "Air Filters", JB / T 6417-1992 "Air Filters for Air Conditioners", and GB / T 6165-2008 "Test Methods for Air Filter Performance - Filtration Efficiency and Resistance". The detection methods include three types: sodium flame method, oil mist method, and counting method. The high-efficiency filter screen with the sodium flame method as the reference method is used here, and the filtration grade is not limited. For example, a G4-grade filter screen can be selected. Of course, the fan of the present invention is a centrifugal fan, so a higher-grade filter screen can be adapted to achieve a better filtering effect while ensuring the smoothness of the air outlet. At the same time, in order to effectively disinfect the workstation room, ultraviolet disinfection lamps 12 are arranged in parallel on both sides of the top plate 4 to remove viruses that may exist in the aerosol. The ultraviolet disinfection lamps 12 can also be arranged in parallel in multiple numbers. Of course, in order to better ensure the sterilization and disinfection effect, ultraviolet disinfection lamps can be further arranged between the fan and the filter screen, which is not limited here.

[0039] The gas filtered by the HEPA high-efficiency filter screen 8 is discharged and diffused through the filter air outlet 6 provided on the cover plate 5, as Figure 4 shown. The opening of the filter air outlet 6 faces the direction of the rear side plate, avoiding direct inhalation or contact of the gas by the experimental personnel. At the same time, the protruding cap-shaped design can ensure that even if something is piled up on the air outlet, the air outlet can still proceed smoothly, and it will not cause the situation that the machine cannot operate when there are piled-up objects at the top. Of course, at this time, the internal pressure sensor of the instrument can be relied on to obtain the internal and external pressure difference relationship to determine whether the air outlet is blocked and give a warning message.

[0040] In this embodiment, when the workstation is working, the three fans 7 are started simultaneously to blow air outwards, and the rotation speed can be adjusted to 3500 rpm, and the air volume per minute can reach 1 m 3 , so that a negative pressure environment is formed inside the entire workstation to ensure the orderly flow of air. At the same time, the HEPA high-efficiency filter screen 8 is used for exhaust filtration, and pollutants such as solid particles, bacteria, and aerosols generated in the working chamber can be completely removed.

[0041] Preferably, in order to control the negative pressure in the working chamber in real time and maintain it within a certain range, the negative pressure system is further provided with a wind pressure sensor 9 for detecting the air pressure values in the working chamber and the external atmospheric environment. The wind pressure sensor 9 is arranged in the top plate 4 and is connected to two air holes provided in the top plate 4. The first air hole 10 faces the inside of the workstation and is used to detect the internal air pressure (preferably, there is a preset distance between the first air hole 10 and the inlet of the fan, so as to ensure that it can more truly reflect the real negative pressure around the workbench); the second air hole 11 faces the external environment and is used to detect the external atmospheric pressure (preferably, the second air hole is arranged at the position of the rear side plate of the non-top plate, so as to ensure that the pressure taking port is maximally avoided from being affected by the air outlet 6 and ensure the accuracy of detection). The wind pressure sensor 9 is electrically connected to the controller, and can output the detected pressure difference as an electrical signal and send it to the controller (not shown in the figure), and the controller is electrically connected to the fan to control the fan speed until the pressure difference in the working chamber meets the requirements.

[0042] In this embodiment, the wind pressure sensor 9 is connected to the signal input interface of the controller, and the fan 7 is connected to the signal output interface of the controller. The controller can adopt a PLC controller. The wind pressure sensor 9 converts the collected pressure difference into a voltage or current signal after calculation and processing and transmits it to the controller. The controller adjusts the air volume discharged by the fan in real time according to the control program within the pressure difference range set by the experiment to prevent the spread of pollutants. In addition, in this embodiment, the workstation is further provided with an interaction device (not shown in the figure) for displaying the current working operation status and negative pressure data in real time. The interaction device is connected to the controller. The interaction device can be a control terminal of the capacitive screen type, such as a Pad. It can be set in the instrument to form a part of the instrument. Of course, it can also be connected to the user's mobile terminal through the network for control, and this is not limited here.

[0043] Figure 5The diagram shows the air flow of the anti-pollution filtration system of the biochemical analyzer provided by the present invention during operation. The speed control unit of the fan 7 of the instrument during operation controls the speed of the fan by a preset negative pressure parameter and / or a current negative pressure parameter obtained by the wind pressure sensor. Under the action of the fan, the air around the workbench 14 is sucked into the inlet of the fan under the action of negative pressure, wherein the energy output by the fan motor is transferred to the air, thereby increasing its velocity pressure head and static pressure head. A preset rectifying channel 13 is included between the air outlet of the fan 7 and the filter 8, which is used to fully develop the airflow delivered by the fan so as to flow into the external environment more evenly through the filter. The volume and other parameters of the preset rectifying channel can be calculated by numerical simulation (CFD simulation calculation), so that the turbulent vortex formed at the fan outlet can be regularized so as to minimize the turbulent dissipation of the entire flow. Of course, the dissipation coefficient can be used here to optimize the specific parameter design of the preset rectifying channel 13, especially for In the scenario of multiple fans running in parallel of the present invention, it is more necessary to optimize the design of the preset rectifying channel 13 due to the differences in the operations of different fans themselves. Optimally, no physical partitions are set in the channels between the outlets of the multiple fans of the present invention, so that the difference in the air delivered by the air outlets of different fans can be fully utilized to interact in the preset rectifying channel 13, thereby achieving a self-rectifying effect. In this way, a design with minimal flow turbulence dissipation is achieved, so that the outlet air can be more evenly distributed to various parts of the filter 8, thereby ensuring the maximum filtering effect of the filter. The airflow after filtration is discharged out of the equipment through the air outlet 6. In conjunction with the preset control method adopted by the controller, it is ensured that the system generates the best negative pressure value at the fan inlet with the highest efficiency. The fresh air from the environment can be supplemented into the interior of the instrument through the gaps in various parts of the instrument, thereby dynamically updating the environment around the workbench 14 and minimizing the risk of aerosol contamination. Of course, an additional ultraviolet lamp can be set in the rectifying channel 13 for sterilization to further reduce the possibility of contamination.

[0044] Figure 6 FIG. 1 is a schematic diagram of the relationship between the fan speed and the negative pressure of the present invention. The controller of the present invention includes the fan speed control unit associated with the negative pressure parameter. The fan speed control unit controls the fan speed according to the preset negative pressure parameter and / or the current negative pressure parameter obtained by the wind pressure sensor. The fan speed may have a relationship with the preset negative pressure as follows: Figure 6The linear relationship C01 shown in a), for example, can be a preset negative pressure ΔP = k1*r + β1, where r is the fan speed. This can be understood as the basis for the controller to adjust the fan speed in a first mode associated with the preset negative pressure parameter. The first mode is a linear association mode. As the usage time increases or other situations occur, the first mode has an association relationship with at least one of the usage time, the cleanliness of the usage environment, the blockage condition of the air outlet, etc. At this time, the controller can adaptively correct the first mode of operation to another linear relationship C02, for example, expressed as ΔP = k2*r + β2. Of course, here the controller can also be adaptively modified to a non-linear relationship C03, for example, it can be expressed in the form of ΔP = f1(r, δ), where δ is a correction variable that can be obtained through experiments and pre-set in the controller. Of course, in the association relationship here, the independent variable and the dependent variable of the control parameter can be dimensionless physical quantities, which are not limited here. Of course, it can also be as Figure 6 shown in b). In the experiment, a non-linear association relationship C04 is used as the initial first mode. The controller adjusts the fan speed based on the non-linear first mode associated with the preset negative pressure parameter. As the usage time and the usage environment change, etc., this first mode can be adaptively corrected to a linear C05 mode or still remain in a non-linear form of C06 type, which is not limited here. Of course, the preset negative pressure parameter can be input into the system by any terminal. Such preset negative pressure parameter control can be used as the control basis for the stage of the system or as the full-process control basis. Of course, in a more optimal implementation scheme, the air pressure sensor obtains the current negative pressure parameter in the workbench, which can be used as the control parameter for adjusting the fan speed. The controller adjusts the fan to operate at a speed different from the first target speed based on the current negative pressure parameter. This situation occurs under some conditions such as partial blockage of the air outlet resulting in non-ideal air output. At this time, the controller can cooperate with the negative pressure parameter of the workbench obtained by the air pressure sensor, and on this basis, realize the cooperation of the two to adjust the negative pressure parameter to reach or approach the preset negative pressure parameter set by the user. Of course, the controller also includes a fault diagnosis unit. On the one hand, it can judge whether there is a blockage in the system and whether the fan is operating normally through parameters such as the motor current and voltage. On the other hand, it can also cooperate with the air pressure sensor to judge some special fault states, such as whether the air pressure sensor is normal and whether the system air resistance is too large, etc. At this time, if some fans are damaged and cannot operate normally, the controller can control the speed of other normally working fans to maintain the negative pressure of the workbench to the greatest extent. Of course, if the air pressure sensor is in a fault state, at this time the fan can be continuously controlled according to the first mode stored in the system, ensuring that the experiment will not be aborted or interrupted due to the failure of a certain component during the operation process, and maximizing the reliability of the system. The rest of the scenarios will not be listed and elaborated.

[0045] As Figure 7As shown in the figure, this embodiment provides a negative pressure control method, which is implemented by the negative pressure filtration system. The specific working process includes:

[0046] S1 Obtain the pressure difference between the inside and outside of the instrument detected by the wind pressure sensor;

[0047] Preferably, the wind pressure sensor collects the air pressure difference between the inside of the working chamber and the external environment detected by two air holes.

[0048] S2 The wind pressure sensor feeds back the signal to the controller;

[0049] Preferably, the wind pressure sensor in this embodiment has both signal acquisition and signal processing functions. After compensating for the offset, sensitivity, and nonlinearity of the sensor, it directly outputs a calibrated and temperature-compensated digital signal. In other embodiments, other sensor modules can also be selected, and the analog signal is converted into a digital signal by the processing module and then fed back to the controller.

[0050] S3 The controller executes the corresponding control program according to the preset negative pressure range to adjust the fan speed;

[0051] Preferably, after receiving the signal fed back by the negative pressure sensor, the controller selects the corresponding adjustment amount according to the preset negative pressure range to which the experiment belongs, and sends an execution instruction to the fan. The fan adjusts the speed until the negative pressure is maintained within the preset range.

[0052] In this embodiment, the controller can select a PLC controller and adopt a differential pressure closed-loop control algorithm to dynamically adjust the fan speed. In addition, the set negative pressure value of the experiment is divided into multiple ranges such as -10Pa to -6Pa / -6Pa to -3Pa / -3Pa to 0Pa, etc. The controller selects the corresponding adjustment range according to the feedback signal, calculates through the differential pressure closed-loop control algorithm, and then sends an execution instruction to the fan motor to adjust the fan speed until the negative pressure of the workstation is maintained within the range corresponding to the experimental program.

[0053] That is:

[0054] Set -10Pa to -6P control, adjust the fan speed until the pressure difference between the inside and outside of the workstation is maintained within the range of -10Pa to -6Pa;

[0055] Set -6Pa to -3Pa control, adjust the fan speed until the pressure difference between the inside and outside of the workstation is maintained within the range of -6Pa to -3Pa;

[0056] Set -3Pa to 0Pa control, adjust the fan speed until the pressure difference between the inside and outside of the workstation is maintained within the range of -3Pa to 0Pa.

[0057] In other embodiments, different negative pressure values and different negative pressure ranges can also be set according to the needs of the experimental procedure (such as a controlled range of -20 Pa to 0 Pa, etc.), so that the negative pressure of the workstation is maintained within the range set by the program. The above all fall within the protection scope of the present invention.

[0058] S4 The controller feedback interaction device displays the current working state and real-time data;

[0059] Preferably, for the convenience of the experimenter to view the operation state of the workstation and related operations, the instrument is also provided with a man-machine interaction device connected to the controller. In this embodiment, the interaction device uses a touch display screen, which can display the detected sensor data and the set experimental program. The experimenter can start the negative pressure control program through the interaction device to realize the negative pressure environment of the workstation. As Figure 8 shown, the experimenter operates the running program on the touch display screen and obtains the real-time sensing data received by the signal interface. Of course, the negative pressure requirement input by the user in the above control process can be directly understood as the preset negative pressure, so as to convert the multi-stage control relationship described in this embodiment into a linear or non-linear first mode to pre-control the fan speed. And if the situation where the user-set negative pressure requirement cannot be achieved all the time under the first-mode control occurs during the process, the value of the air pressure sensor can be used as the basis for adjusting the fan speed at this time, so as to approach or even reach the user-set negative pressure requirement, which is not limited here.

[0060] Those skilled in the art of this industry should understand that the present invention is not limited by the above embodiments. What is described in the above embodiments and the specification only illustrates the principle of the present invention. Without departing from the spirit and scope of the present invention, the present invention will have various changes and improvements, and these changes and improvements all fall within the scope of the present invention claimed. The scope of protection claimed by the present invention is defined by the appended claims and their equivalents.

Claims

1. A biochemical analyzer anti-pollution filtration system, characterized in that: It includes a workbench in a negative pressure environment. The top of the workbench includes a top plate, and above the top plate is the cover plate of the system. A negative pressure generation chamber is formed between the top plate and the cover plate. The negative pressure generation chamber is provided with a plurality of air ducts. Each air duct includes an air outlet and an air inlet. Each air duct further includes a fan disposed at the air inlet of the negative pressure generation chamber, a filter disposed at the air outlet of the negative pressure generation chamber, and a preset rectification channel disposed between the air outlet of the fan and the filter. The air inlet of the negative pressure generation chamber and the fan are disposed on the top plate, and the air outlet of the negative pressure generation chamber and the filter are disposed on the cover plate. Multiple fans operate in parallel, and there is no physical partition in the channel between the outlets of multiple fans. The differences in the air sent out from the outlets of different fans interact fully in the preset rectification channel to achieve self-rectification. At the same time, the volume of the preset rectification channel is calculated through numerical simulation to achieve the design with the minimum flow turbulence dissipation, so that the air outlet can be more evenly distributed to various places of the filter, ensuring the maximum filtering effect of the filter. The parameters of the rectification channel are designed based on the dissipation coefficient. The rectification channel is used to fully develop the air flow sent out by the fan so that it can flow into the external environment more evenly through the filter. The negative pressure generation chamber is used to provide a negative pressure environment for the workbench; it also includes a wind pressure sensor disposed on the top plate of the workbench, and a controller electrically connected to the fan and the wind pressure sensor. The controller includes a fan speed control unit associated with negative pressure parameters; the fan speed control unit controls the fan speed by the preset negative pressure parameter and / or the current negative pressure parameter obtained by the wind pressure sensor; the controller further includes a fault diagnosis unit, which can judge whether the wind pressure sensor is normal through at least one parameter of the current and voltage during the operation of the fan.

2. The biochemical analyzer anti-pollution filtration system according to claim 1, wherein: The filter is a HEPA high-efficiency filter screen.

3. A control method for a biochemical analyzer anti-pollution filtration system as claimed in claim 1, characterized in that, It includes a preset negative pressure acquisition unit to obtain a preset negative pressure parameter, and the controller adjusts the fan speed to a first target speed in a first mode associated with the preset negative pressure parameter. The wind pressure sensor obtains the current negative pressure parameter inside the workbench and outputs it.

4. The control method according to claim 3, wherein The first mode is an adaptive adjustment association mode associated with at least one of the usage time, the cleanliness of the usage environment, and the blockage condition of the air outlet.

5. The control method according to claim 3, wherein The current negative pressure parameter obtained by the wind pressure sensor inside the workbench can be used as a control parameter for adjusting the fan speed. The controller adjusts the fan to operate at a speed different from the first target speed with the current negative pressure parameter.

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