Anchoring device and anchor

Abstract

The present application provides an anchoring device and an anchor, mainly including a guiding shaft and an anchor. The guiding shaft includes a positioning portion extending along its axial direction. The anchor is in a spiral structure and is movably sleeved on the outer periphery of the guiding shaft. Among them, the guiding shaft can be positioned relative to the target tissue by means of the positioning portion. The anchor can rotate circumferentially and move axially relative to the guiding shaft, so that a part of the anchor penetrates into the target tissue, and the axial direction of the guiding shaft is parallel to the exposed surface of the target tissue. Thus, the anchoring device of the present application has the advantages of not being easily detached and having a long service life, and the target tissue in the anchored state can withstand a large traction force by the anchor and is not easily torn.

Description

Technical Field

[0001] The embodiments of the present application relate to the technical field of medical devices, and particularly to an anchoring device and an anchor Background Art

[0002] Common diseases of human heart valves include valvular insufficiency, leaflet prolapse, etc. Taking the mitral valve as an example, during the systolic phase of the heart, a part of the blood in the left ventricle flows back into the left atrium through the insufficient mitral valve orifice. The left atrium simultaneously receives the blood flowing back from the left ventricle and the blood input from the pulmonary veins, resulting in a significant increase in the blood volume and pressure in the left atrium, leading to left atrial hypertrophy. During the diastolic phase of the heart, more blood flows from the left atrium to the left ventricle, causing the left ventricle to hypertrophy due to enhanced contraction. After evolving from the compensatory stage to the decompensated stage, heart failure occurs in both the left atrium and the left ventricle, and then pulmonary congestion, pulmonary hypertension, right ventricular hypertrophy, right atrial hypertrophy, right heart failure, and systemic congestion occur in sequence

[0003] Traditional treatment methods include actively performing surgical procedures or palliatively using drugs to combat inevitable heart failure. Among them, surgical methods also include valve replacement and valvuloplasty. In surgical methods, typical open-chest surgeries are highly invasive, require extracorporeal circulation to be established, and have a high incidence of complications and infection risks. Many patients cannot tolerate the huge surgical risks

[0004] Currently, the commonly used techniques for minimally invasive transcatheter treatment of mitral and tricuspid regurgitation are valve replacement and annulus repair. Among them, one of the difficulties in annulus replacement technology is to reliably fix the replacement device on the human heart tissue, and the anchoring technology is one of the commonly used fixing methods. The annulus repair technology requires anchoring the preset target soft tissue of the heart, so as to form the valve or fix the repair device by pulling the preset anchor points. The commonly used technique for transcatheter treatment of leaflet prolapse is to establish artificial chordae on the leaflets and then anchor them on the atrial tissue. In summary, a reliable anchoring device plays an important role in transcatheter treatment of structural heart diseases Summary of the Invention

[0005] In view of the above problems, the present application provides an anchoring device and an anchor to overcome or at least partially solve the above problems

[0006] An embodiment of the present application provides an anchoring device, which includes a guiding shaft having a positioning portion extending along its axial direction; and an anchor having a spiral structure; wherein, the guiding shaft can be positioned relative to the target tissue by means of the positioning portion, and the anchor can rotate circumferentially and move axially relative to the guiding shaft, so that a part of the anchor penetrates into the target tissue, and the axial direction of the guiding shaft is parallel to the exposed surface of the target tissue

[0007] Optionally, the radial cross-section of the guiding shaft is any one of circular, triangular, rectangular, trapezoidal, and polygonal.

[0008] Optionally, the positioning portion can be attached to the exposed surface of the target tissue for positioning the guiding shaft relative to the target tissue.

[0009] Optionally, the anchoring device further includes an interference member that, together with the guiding shaft, defines an interference channel extending axially along the guiding shaft; wherein, the interference channel allows the anchor to pass through, and is used to provide interference to the movement tendency of the anchor during the circumferential rotation and axial movement of the anchor relative to the guiding shaft, so as to maintain a preset relative position between the anchor and the guiding shaft.

[0010] Optionally, the guiding shaft includes a first interference structure extending axially along it, and the interference member includes a second interference structure corresponding to the first interference structure. The first interference structure and the second interference structure extend parallel to each other to form opposite sides of the interference channel.

[0011] Optionally, the radial cross-section of the interference channel is arc-shaped.

[0012] Optionally, either the interference member and the anchor are non-detachably connected, detachably connected, or not connected at all.

[0013] Optionally, the interference member is further provided with a guiding structure for guiding the anchor into the interference channel.

[0014] Optionally, the anchor further includes a spike portion for piercing the target tissue to perform penetration.

[0015] Optionally, the interference channel includes a plurality of longitudinally guiding grooves arranged in parallel, wherein the spike portion of the anchor can travel along the movement trajectory defined by each of the longitudinally guiding grooves, so that the anchor rotates circumferentially and moves axially relative to the guiding shaft.

[0016] Optionally, the interference member is provided with an alignment structure for providing a channel entrance for the anchor to access each of the longitudinally guiding grooves in the interference channel via the channel entrance.

[0017] Optionally, the anchor is composed of a plurality of non-closed rings connected in sequence, wherein when the anchor penetrates into the target tissue, the first part of each non-closed ring penetrates into the target tissue.

[0018] Optionally, the second part of each non-closed ring exposed outside the target tissue can be used to apply a force, and the force is applied to the target tissue via the first part of each non-closed ring.

[0019] Optionally, the guiding shaft further includes a first engaging portion for engaging with a first delivery system to deliver the guiding shaft to a first preset position corresponding to the target tissue or evacuate from the first preset position by means of the first delivery system; the anchoring member further includes a second engaging portion for engaging with a second delivery system to deliver the anchoring member to a second preset position corresponding to the guiding shaft by means of the second delivery system, and controlling the circumferential rotation and axial movement of the anchoring member relative to the guiding shaft to penetrate into the target tissue.

[0020] Another embodiment of the present application provides an anchoring member, the anchoring member has a spiral structure, and a part of the anchoring member can penetrate into the target tissue, and the axial direction of the guiding shaft in the anchored state is parallel to the exposed surface of the target tissue.

[0021] Optionally, the anchoring member is composed of a plurality of non-closed rings connected in sequence, wherein when the anchoring member penetrates into the target tissue, the first part of each non-closed ring penetrates into the target tissue.

[0022] Optionally, the second part of each non-closed ring exposed outside the target tissue is available for applying a force, and the force is applied to the target tissue through the first part of each non-closed ring.

[0023] As can be seen from the above technical solutions, the anchoring device and the anchoring member of the embodiments of the present application anchor the human tissue in a lateral manner, that is, along the axial direction of the anchoring member, and can have the advantage that the anchoring member is not easily detached after anchoring the human tissue.

[0024] Furthermore, the anchoring member of the present application can evenly distribute the external force to the human tissue, and the lateral anchoring scheme of the present application can form a plurality of closed perforation holes in the target tissue, so that the human tissue can withstand a large traction force through the anchoring member and is not easily torn, especially suitable for the annuloplasty technique. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the drawings in the following description are only some embodiments recorded in the embodiments of the present application, and those of ordinary skill in the art can also obtain other drawings based on these drawings.

[0026] Figure 1 is a schematic structural diagram of an anchoring device in the prior art;

[0027] Figure 2Schematic diagram of the overall structure of the anchoring device according to an embodiment of the present application;

[0028] Figures 3 to 4 Schematic diagram of an embodiment where the anchoring device is positioned on the target tissue;

[0029] Figures 5A to 7 Embodiment diagrams of different connection relationships between the interference member and the guide shaft;

[0030] Figure 8 Schematic diagram of the structure of the anchoring member;

[0031] Figures 9 to 14 Schematic diagrams of different states of the anchoring member penetrating into the target tissue;

[0032] Figures 15 to 19 Schematic diagram of the structure of the anchoring device according to another embodiment of the present application;

[0033] Figures 20 to 22 Schematic diagrams of different operating states of the anchoring device of the present application applied to cardiac tissue anchoring.

[0034] Element label 1: Anchoring device (prior art); 11: Spiral tissue coupling element; 12: Target tissue;

[0035] 121: Exposed surface;

[0036] 2: Anchoring device (present application)

[0037] 21: Guide shaft;

[0038] 211: Positioning portion;

[0039] 212: First interference structure;

[0040] 213: First coupling portion; 22: Anchoring member;

[0041] 221: Non-closed loop;

[0042] 222: Spiked portion;

[0043] 223: Second coupling portion; 23: Interference member;

[0044] 230: Interference channel;

[0045] 231: Second interference structure;

[0046] 232: Longitudinal guiding groove; 233: Guiding structure;

[0047] 2331: First inclined surface; 2332: Second inclined surface; 234: Alignment structure;

[0048] 2340: Channel entrance; 235: Third coupling portion;

[0049] 3: Target organization;

[0050] 31: Exposed surface;

[0051] 4: The first conveying system;

[0052] 41: guide rail;

[0053] 5: valve ring;

[0054] 51: Annular surface. DETAILED DESCRIPTION

[0055] In order to enable those skilled in the art to better understand the technical solutions in the embodiments of the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. All other embodiments obtained by ordinary technicians in this field based on the embodiments in the embodiments of the present application should fall within the scope of protection of the embodiments of the present application.

[0056] The distal end mentioned below refers to the end of the relevant instrument or device far away from the operator, and the proximal end refers to the end of the relevant instrument or device close to the operator.

[0057] As mentioned in the background technology section, reliable anchoring devices play an important role in transcatheter treatment of structural heart diseases.

[0058] Currently commonly used soft tissue anchoring devices 1 (reference Figure 1 ), the axial direction of the spiral tissue coupling element 11 is perpendicular to the exposed surface 121 of the target tissue 12, so that the distal end of the spiral tissue coupling element 11 gradually spirally penetrates the target tissue 12 along the vertical direction for anchoring. The problem with this solution is that since the spiral tissue coupling element 11 is in a spiral shape, it will generate a slipping force, and the target tissue is easily deformed and damaged when subjected to force, resulting in the risk of the spiral tissue coupling element 11 falling off.

[0059] In view of this, each embodiment of the present application provides an anchoring technical solution that is not easy to fall off. The specific implementation of the embodiments of the present application will be further explained below in conjunction with the drawings of the embodiments of the present application.

[0060] like Figures 2 to 4 As shown, the anchoring device 2 of the present application includes a guide shaft 21 and an anchoring member 22 .

[0061] The guide shaft 21 includes a positioning portion 211 extending along its axial direction, and the anchoring member 22 is a spiral structure.

[0062] In this embodiment, the guiding shaft 21 can be positioned relative to the target tissue 3 by the positioning portion 211, and the anchoring member 22 can rotate circumferentially and move axially relative to the guiding shaft 21, so that a part of the anchoring member 22 penetrates into the target tissue 3, and the axial direction of the guiding shaft 21 is parallel to the exposed surface 31 of the target tissue 3 (refer to Figures 9 to 12 ).

[0063] Accordingly, in this embodiment, by making the anchoring member 22 perform penetration and anchoring on the target tissue 3 along a direction parallel to the target tissue 3, the anchoring stability can be improved and the advantage of not being easily detached can be achieved.

[0064] Optionally, the radial cross-section of the guiding shaft 21 can be circular (refer to the embodiment of Figures 2 to 12 ), triangular (refer to the embodiment of Figures 15 to 19 ). However, this is not limited thereto. The radial cross-section of the guiding shaft 21 can also be rectangular, trapezoidal or polygonal (not shown), etc., and the present application does not limit this.

[0065] Optionally, the positioning portion 211 can be attached to the exposed surface 31 of the target tissue 3 for positioning the guiding shaft 21 relative to the target tissue 3 (refer to Figure 3 and Figure 4 ).

[0066] In this embodiment, when the radial cross-section of the guiding shaft 21 is circular, the positioning portion 211 is an arc surface extending along the axial direction of the guiding shaft 21 (refer to Figure 3 , Figure 4 ), and when the radial cross-section of the guiding shaft 21 is triangular, the positioning portion 211 is a plane extending along the axial direction of the guiding shaft 21 (refer to Figure 15 , Figure 16 )

[0067] Optionally, the guiding shaft 21 further includes a first coupling portion 213 (refer to Figure 3 ), which is used to couple with a first delivery system (not shown) to deliver the guiding shaft 21 to a preset position corresponding to the target tissue 3 by the first delivery system, or to withdraw the guiding shaft 21 from the preset position by the first delivery system.

[0068] In this embodiment, the anchoring instrument 2 further includes an interference member 23, which together with the guiding shaft 21 defines an interference channel 230 extending along the axial direction of the guiding shaft 21.

[0069] Among them, the interference channel 230 allows the anchor 22 to pass through. During the circumferential rotation and axial movement of the anchor 22 relative to the guide shaft 21, interference is provided to the movement trend of the anchor 22, so as to maintain a preset relative position between the anchor 22 and the guide shaft 21. Thereby, it can be ensured that the relative position of the anchor 22 relative to the target tissue 3 remains stable during the movement process, making the respective anchoring positions of the anchor 22 relative to the target tissue 3 relatively balanced (for example, the interval distance and the anchoring depth between the respective anchoring positions on the target tissue 3 are all the same), thereby improving the anchoring effect.

[0070] Optionally, the guide shaft 21 includes a first interference structure 212 extending along its axial direction, and the interference member 23 includes a second interference structure 231 corresponding to the first interference structure 212. The first interference structure 212 and the second interference structure 231 extend parallel to each other to form opposite sides of the interference channel 230.

[0071] Optionally, when the radial cross-section of the guide shaft 21 is circular, the first interference structure 212 and the second interference structure 231 can be two arc surfaces with a structurally adapted shape, such that the radial cross-section of the interference channel 230 is arc-shaped (refer to Figure 4 ), but it is not limited thereto. The first interference structure 212 and the second interference structure 231 can also be other shapes such as planar or triangular. The present application does not limit this.

[0072] Optionally, the interference member 23 and the guide shaft 21 can be any one of non-detachable connection, detachable connection, and no connection.

[0073] For example, the interference member 23 and the guide shaft 21 can be integrally formed or designed as a non-detachable fixed connection (refer to Figure 5A and Figure 5B ). In this case, after the anchor 22 completes the operation of penetrating into the target tissue 3, the interference member 23 and the guide shaft 21 can be left in the body together according to actual needs (such as the structure shown in Figure 5A ) or withdrawn from the body together (such as the structure shown in Figure 5B ).

[0074] Another example is that a mutually independent separating element can also be designed between the interference member 23 and the guide shaft 21, that is, there is no substantial connection relationship between the interference member 23 and the guide shaft 21 (refer to Figure 6 ), and the relative position relationship between the two can be restricted by medical auxiliary operating instruments such as a delivery system, thereby defining the above-mentioned interference channel 230. In this case, after the anchor 22 completes the operation of penetrating into the target tissue 3, the interference member 23 can be withdrawn from the body, and the guide shaft 21 can be left in the body or withdrawn from the body according to actual needs.

[0075] For another example, the interference member 23 and the guide shaft 21 can also be designed as a detachable connection design (refer to Figure 7 ). For example, the interference member 23 and the guide shaft 21 can be detachably connected by a snap connection. In this case, after the anchoring member 22 completes the operation of penetrating the target tissue 3, the interference member 23 can be separated from the anchoring member 22 to evacuate the interference member 23 from the body, and the guide shaft 21 can also be left in the body or removed from the body according to actual needs.

[0076] Optionally, the interference member 23 further includes a third engaging portion 235, which can be used to engage with a third delivery system (not shown) to deliver the interference member 23 to a preset position corresponding to the target tissue 3 (the position relative to the guide shaft 21) or evacuate from the preset position of the target tissue 3 by means of the third delivery system. It should be noted that the setting position of the third engaging portion 235 is not limited to that shown in the drawings of the present application and can be changed according to actual operation requirements.

[0077] Optionally, the interference member 23 is further provided with a guiding structure 233, which can be used to guide the anchoring member 22 into the interference channel 230.

[0078] In this embodiment, the guiding structure 233 includes a first inclined surface 2331 provided on the guide shaft 21 and a second inclined surface 2332 on the interference member 23 (refer to FIGS. 5 and Figure 6 ), so as to form a flared inlet at the proximal end of the interference channel 230 (i.e., the end close to the operator) to facilitate guiding the anchoring member 22 to smoothly enter the interference channel 230.

[0079] It should be noted that the guiding structure 233 is not limited to the above-mentioned flared inlet structure design and can also be changed according to actual design and / or use requirements.

[0080] As Figure 8 shown, the anchoring member 22 of this embodiment further includes a spike portion 222. In this embodiment, the spike portion 222 can be provided at the distal end of the anchoring member 22 for piercing the target tissue 3 so that the anchoring member 22 penetrates into the target tissue 3 and anchors.

[0081] In this embodiment, the anchoring member 22 further includes a second engaging portion 223, which is used to engage with a second delivery system (not shown) to deliver the anchoring member 22 to a second preset position corresponding to the guide shaft 21, and control the circumferential rotation and axial movement of the anchoring member 22 relative to the guide shaft 21 to penetrate into the target tissue 3.

[0082] Please refer to Figure 13 、 Figure 14, in this embodiment, the anchor 22 is composed of a plurality of non-closed loops 221 connected in sequence. Among them, when the anchor 22 is driven into the target tissue 3, the first part of each non-closed loop 221 (for example, the part of each non-closed loop 221 located in Figure 14 the area A) penetrates into the target tissue 3.

[0083] Furthermore, the second part of each non-closed loop 221 exposed outside the target tissue 3 (for example, the part of each non-closed loop 221 located in Figure 14 the area B) can be used to apply a force, and the force is applied to the target tissue 3 through the first part of each non-closed loop 221.

[0084] In this embodiment, each non-closed loop 221 has the same spacing distance. Thereby, the force applied to the anchor 22 can be evenly distributed to each non-closed loop 221, and then the force is evenly dispersed to each anchoring part of the target tissue 3 through each non-closed loop 221. Therefore, the anchor 2 of the present application can not only bear a large traction force, but also effectively avoid the problem that the target tissue 3 is torn by force and the anchor 22 falls off because the force application points of the target tissue 3 are dispersed and uniform.

[0085] Please refer to Figures 17 to 19 , in an embodiment, the interference channel 230 further includes a plurality of longitudinally guiding grooves 232 arranged in parallel. Among them, the spike part 222 of the anchor 22 can travel along the movement trajectory defined by each longitudinally guiding groove 232, so that the anchor 22 rotates circumferentially and moves axially relative to the guiding shaft 21.

[0086] In this embodiment, the spacing distance of each longitudinally guiding groove 232 corresponds to the spacing distance of each non-closed loop 221 of the anchor 22.

[0087] Preferably, the interference member 23 is provided with an alignment structure 234 for providing a channel entrance 2340 for the anchor 22 to access each longitudinally guiding groove 232 in the interference channel 230 through the channel entrance 2340.

[0088] In this embodiment, the alignment structure 234 is arranged at the proximal end of the interference member 23. By squeezing a part of the target tissue 3 located at the proximal end of the interference member 23, a channel entrance 2340 is formed at the proximal end of the guiding shaft 21, so that the anchor 22 can smoothly enter each longitudinally guiding groove 232 in the interference channel 230 through the channel entrance 2340.

[0089] The following will combine Figures 20 to 22 , and illustrate the implementation scheme of using the anchor device 1 of the present application to anchor the heart tissue as follows:

[0090] First, the guiding shaft 21 and the interference member 23 are conveyed to a preset position of the human heart by the first conveying system 4 having a guide rail 41, and the positioning portion 211 of the guiding shaft 21 is attached to the annulus surface 51 of the annulus 5 to be anchored (refer to Figure 20 ).

[0091] The anchoring member 22 is threaded on the guide rail 41 of the first conveying system 4, and the anchoring member 22 is pushed along the guide rail 41 to the proximal end of the guiding shaft 21 by a second conveying system (not shown), and the anchoring member 22 is controlled to rotate circumferentially and move axially relative to the guiding shaft 21 so that a part of the anchoring member 22 penetrates into the annulus 5 for anchoring (refer to Figure 21 ).

[0092] After the anchoring is completed, according to actual needs, the guiding shaft 21 and the interference member 23 can be left in the heart tissue (refer to Figure 22 the state shown), or the interference member 23 can be withdrawn and the guiding shaft 21 can be retained in the heart tissue (refer to Figure 7 the state shown), or the interference member 23 and the guiding shaft 21 can be withdrawn from the heart tissue together (refer to Figure 13 , Figure 14 the state shown).

[0093] In summary, the anchoring device and the anchoring member of the present application provide an anchor to anchor the target tissue along the axial direction of the anchoring member, and have the advantage that the anchoring member penetrating into the target tissue is not easily detached.

[0094] Furthermore, since the anchoring member of the present application penetrates the target tissue in a lateral manner, the traction force applied to the anchoring member can be evenly distributed over various parts of the target tissue. At the same time, compared with the existing longitudinal anchoring scheme that forms a single and open anchoring hole in the target tissue, the lateral anchoring scheme of the present application forms a plurality of closed through holes in the target tissue. Therefore, the target tissue can withstand a large traction force through the anchoring member and is not easily torn, especially suitable for annuloplasty techniques.

[0095] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the embodiments of the present application, and are not intended to limit them; although the present application has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements for some of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present application.

Claims

1. An anchoring device, characterized in that, it includes: a guiding shaft, which includes a positioning portion extending along its axial direction; and an anchor, which has a spiral structure; wherein, the guiding shaft can be positioned relative to the target tissue by means of the positioning portion, and the anchor can rotate circumferentially and move axially relative to the guiding shaft, so that a part of the anchor penetrates into the target tissue, and the axial direction of the guiding shaft is parallel to the exposed surface of the target tissue; the anchoring device further includes: an interference member, which together with the guiding shaft defines an interference channel extending along the axial direction of the guiding shaft; wherein, the interference channel is for the anchor to pass through, and is used to provide interference to the moving trend of the anchor during the process of the anchor rotating circumferentially and moving axially relative to the guiding shaft, so as to maintain a preset relative position between the anchor and the guiding shaft; the guiding shaft includes a first interference structure extending along its axial direction, and the interference member includes a second interference structure corresponding to the first interference structure, and the first interference structure and the second interference structure extend parallel to each other to form opposite sides of the interference channel.

2. The anchoring device according to claim 1, characterized in that, the radial cross-section of the guiding shaft is any one of circular, triangular, rectangular, and trapezoidal.

3. The anchoring device according to claim 1, characterized in that, the positioning portion can be attached to the exposed surface of the target tissue for positioning the guiding shaft relative to the target tissue.

4. The anchoring device according to claim 1, characterized in that, the radial cross-section of the interference channel is arc-shaped.

5. The anchoring device according to claim 1, characterized in that, the interference member and the anchor are any one of non-detachable connection, detachable connection, and no connection.

6. The anchoring device according to claim 1, characterized in that, the interference member is further provided with a guiding structure for guiding the anchor into the interference channel.

7. The anchoring device according to claim 1, characterized in that, the anchor further includes a spike portion for piercing the target tissue to perform penetration.

8. The anchoring device according to claim 7, characterized in that, the interference channel includes a plurality of longitudinally guiding grooves arranged in parallel, wherein the spike portion of the anchor can travel along the moving track defined by each longitudinally guiding groove, so that the anchor rotates circumferentially and moves axially relative to the guiding shaft.

9. The anchoring device according to claim 8, characterized in that, the interference member is provided with an alignment structure for providing a channel entrance for the anchor to access each longitudinally guiding groove in the interference channel through the channel entrance.

10. The anchoring device according to claim 1, characterized in that, the anchor is composed of a plurality of non-closed rings connected in sequence, and when the anchor penetrates into the target tissue, the first part of each non-closed ring penetrates into the target tissue respectively.

11. The anchoring device according to claim 10, characterized in that, Each of the non-closed loops is exposed to a second part of the target tissue for applying a force, and the force is applied to the target tissue via each of the first parts of each of the non-closed loops.

12. The anchoring device according to claim 1, wherein, the guiding shaft further includes a first coupling portion for coupling to a first delivery system to deliver the guiding shaft to a first predetermined position corresponding to the target tissue or withdraw from the first predetermined position by means of the first delivery system; the anchoring member further includes a second coupling portion for coupling to a second delivery system to deliver the anchoring member to a second predetermined position corresponding to the guiding shaft by means of the second delivery system, and controlling the circumferential rotation and axial movement of the anchoring member relative to the guiding shaft to penetrate into the target tissue.

13. The anchoring device according to claim 12, wherein, the interference member further includes a third coupling portion for coupling to a third delivery system to deliver the interference member to the first predetermined position or withdraw from the first predetermined position by means of the third delivery system; wherein the third delivery system and the first delivery system are the same or different delivery systems.

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