A fully automatic solid phase extractor with optional nitrogen blowing

Abstract

The invention discloses a fully automatic solid phase extractor with optional nitrogen blowing, wherein a first sample rack placement platform and a second sample rack placement platform are arranged side by side on the bottom plate, and are respectively slid forward and backward. The first sample rack can be detachably fixed on the first sample rack placement platform, and the second sample rack or a water bath can be detachably fixed on the second sample rack placement platform. When the water bath is fixed, the second sample rack falls into the water bath; the injection needle moves left and right and up and down above the first sample rack and the second sample rack to insert or withdraw the sample tube on the first sample rack or the second sample rack; the SPE column disk is located above the second sample rack, the column plug rod is located above the SPE column disk, and the column plug rod driving component drives the column plug rod to insert or withdraw the SPE column; a nitrogen blowing module is detachably installed on the bottom plate, the nitrogen blowing module and the SPE column disk are arranged side by side front and back, and the nitrogen blowing driving component thereon drives the nitrogen blowing needle to insert or withdraw the sample tube on the second sample rack. The nitrogen blowing module can be selectively expanded and installed on the solid phase extractor.

Description

Technical Field

[0001] The invention relates to the technical field of solid phase extraction, in particular to a full-automatic solid phase extractor which can be optionally equipped with nitrogen blowing. Background Art

[0002] After solid phase extraction, nitrogen blowing and concentration are sometimes required. Currently, a solid phase extractor and a nitrogen blowing instrument are usually required to complete the extraction and nitrogen blowing and concentration processes respectively. After the sample is extracted by the solid phase extractor, the sample is transferred to the nitrogen blowing instrument for nitrogen blowing and concentration, which is extremely inconvenient.

[0003] If the nitrogen blowing module can be flexibly installed on the solid phase extractor according to user needs, so that solid phase extraction and nitrogen blowing concentration can be automatically completed on one device, the solid phase extractor will be more versatile. Summary of the invention

[0004] The object of the present invention is to provide a fully automatic solid phase extractor with optional nitrogen blowing, so as to overcome the above-mentioned defects and realize the selective expansion and installation of a nitrogen blowing module on the solid phase extractor.

[0005] To achieve the above-mentioned purpose, the solution of the present invention is: a fully automatic solid phase extractor with optional nitrogen blowing, comprising a bottom plate, a first sample rack placement table, a second sample rack placement table, a first sample rack drive assembly, a second sample rack drive assembly, an injection needle drive assembly, an injection needle, an SPE column disk, a column plug rod, and a column plug rod drive assembly, the injection needle and the column plug rod are connected with a switching valve, the switching valve is connected with a syringe pump, a first sample rack is detachably fixed above the first sample rack placement table, a second sample rack or a water bath is detachably fixed above the second sample rack placement table, when a water bath is fixed above the second sample rack placement table, the second sample rack falls into the water bath, sample tubes are placed on the first sample rack and the second sample rack, and an SPE column is placed on the SPE column disk;

[0006] The first sample rack placement table and the second sample rack placement table are arranged side by side on the bottom plate and slide forward and backward respectively, the first sample rack driving component is connected to and drives the first sample rack placement table to drive the first sample rack to move forward and backward, and the second sample rack driving component is connected to and drives the second sample rack placement table to drive the second sample rack to move forward and backward;

[0007] The injection needle driving assembly is connected to and drives the injection needle to move left and right and up and down above the first sample rack and the second sample rack to insert or withdraw the sample tube on the first sample rack or the second sample rack;

[0008] The SPE column plate is located above the second sample rack, the column insertion rod is located above the SPE column plate, and the column insertion rod driving assembly is connected to and drives the column insertion rod to descend to insert or ascend to withdraw the SPE column on the SPE column plate;

[0009] A nitrogen blowing module is detachably mounted on the bottom plate. The nitrogen blowing module is arranged side by side with the SPE column disk, and comprises a nitrogen blowing needle and a nitrogen blowing driving assembly. The nitrogen blowing needle is connected to a gas distribution device. The nitrogen blowing driving assembly is connected to and drives the nitrogen blowing needle to descend and insert into or ascend and withdraw from the sample tube on the second sample rack.

[0010] Furthermore, the switching valve is also connected to a plug and a solvent supply module for supplying solvent, and an injection needle cleaning tank for inserting the injection needle is arranged above the first sample rack placement table;

[0011] A fixed valve port is provided in the center of the switching valve, and six switching valve ports are provided in a circular array on the outer circle. The fixed valve port is connected to the injection pump. The six switching valve ports are respectively connected to the column rod, the gas distribution device, the injection needle cleaning tank, the solvent supply module, the plug, and the injection needle in turn. The plug is used to block the switching valve port. A first flow path and a second flow path are provided in the switching valve. The first flow path switches the fixed valve port to connect to one of the switching valve ports, and the second flow path switches to connect to two adjacent switching valve ports.

[0012] Furthermore, a gun tip is sleeved on the lower end of the injection needle, and a gun tip removal mechanism is also arranged above the bottom plate, the gun tip removal mechanism includes a gun tip removal plate and a gun tip removal plate driving mechanism, the gun tip removal plate is longitudinally penetrated by a gun tip removal opening, the gun tip removal opening includes a gun tip insertion section and a gun tip removal section which are adjacently arranged front and back and connected to each other, the gun tip insertion section is used for allowing the gun tip to pass through, the gun tip removal section is used to block the gun tip downwards, and the gun tip removal plate driving mechanism is connected to and drives the gun tip removal plate to move forward and backward.

[0013] Furthermore, the SPE column disk is connected to a column disk driving assembly, and the column disk driving assembly is connected to and drives the SPE column disk to move forward and backward so that each column insertion rod is aligned with an SPE column on the SPE column disk.

[0014] Furthermore, the SPE column disk is provided with a cleaning groove for the column rod to be inserted for cleaning.

[0015] Further, the injection needle drive assembly includes an injection needle beam, an injection needle support plate, an injection needle left-right drive mechanism, an injection needle mounting frame, and an injection needle lifting drive mechanism. The injection needle beam is fixed to the bottom plate and spans over the first sample rack and the second sample rack. The injection needle support plate is slidably connected to the injection needle beam. The injection needle left-right drive mechanism is arranged between the injection needle beam and the injection needle support plate to drive the injection needle support plate to move left and right. The injection needle mounting frame is longitudinally slidably connected to the injection needle support plate. The injection needle lifting drive mechanism is connected between the injection needle support plate and the injection needle mounting frame to drive the injection needle mounting frame to move up and down. The injection needle is mounted on the injection needle mounting frame.

[0016] The column tray driving assembly includes a column tray door frame, a column tray driving mechanism, a column insertion rod support frame, a column insertion rod mounting frame, and a column insertion rod driving mechanism. The column tray door frame is fixed to the base plate and spans left and right above the second sample rack. The SPE column tray is connected to the upper end of the column tray door frame for front and back sliding. The column tray driving mechanism is arranged between the SPE column tray and the column tray door frame to drive the SPE column tray to move back and forth. The column insertion rod support frame is fixed above the column tray door frame. The column insertion rod mounting frame is longitudinally connected to the column insertion rod support frame for front and back sliding. The column insertion rod driving mechanism is arranged between the column insertion rod mounting frame and the column insertion rod supporting frame to drive the column insertion rod mounting frame to rise and fall. The column insertion rod is mounted on the column insertion rod mounting frame.

[0017] The nitrogen blowing driving assembly includes a nitrogen blowing support longitudinal plate, a nitrogen blowing support transverse plate, and a nitrogen blowing driving mechanism. The nitrogen blowing support longitudinal plate is fixed to the bottom plate between the first sample rack and the second sample rack. The nitrogen blowing support transverse plate is longitudinally slidably connected to one side of the nitrogen blowing support longitudinal plate. The nitrogen blowing driving mechanism is arranged between the nitrogen blowing support longitudinal plate and the nitrogen blowing support transverse plate to drive the nitrogen blowing support transverse plate to rise and fall. The nitrogen blowing needle is installed below the nitrogen blowing support transverse plate.

[0018] Furthermore, a protective shell is buckled above the bottom plate, the first sample rack placing table, the second sample rack placing table, the first sample rack drive assembly, the second sample rack drive assembly, the injection needle drive assembly, the injection needle, the SPE column plate, the nitrogen blowing needle, the column plate drive assembly, the column plug rod, the column plug rod drive assembly, and the nitrogen blowing drive assembly are all located in the protective shell, and the front end surface of the protective shell is provided with an injection port and a sampling port at positions corresponding to the first sample rack and the second sample rack, respectively; the switching valve and the injection pump are in the protective shell and are located above the first sample rack, and the protective shell is provided with an inspection window at positions corresponding to the switching valve and the injection pump.

[0019] Furthermore, the top surfaces of the first sample rack and the second sample rack are respectively arrayed with multiple rows of sample tubes, and multiple injection needles are provided, and the multiple injection needles are arranged in a row corresponding to a row of the sample tubes, and the injection needle drive assembly drives the multiple injection needles to move synchronously to insert or withdraw the sample tubes in a row.

[0020] Furthermore, the nitrogen blowing needles are arranged in multiple rows, and the multiple rows of nitrogen blowing needles are arranged in the same manner as the multiple rows of sample tubes on the second sample rack. The nitrogen blowing drive assembly drives the nitrogen blowing needles to move synchronously to insert or withdraw the sample tubes on the second sample rack.

[0021] Furthermore, the SPE column plate is provided with multiple rows of SPE columns, and multiple column insertion rods are provided, and multiple column insertion rods are arranged in a row corresponding to a row of the SPE columns, and the column insertion rod driving assembly drives the multiple column insertion rods to simultaneously insert downward or withdraw upward a row of the SPE columns.

[0022] After adopting the above scheme, the beneficial effect of the present invention is that: by moving the first sample rack and the second sample rack forward and backward, the injection needle can be aligned with the sample tubes on the first sample rack and the second sample rack, and the injection needle driving component drives the injection needle to move left and right and up and down, so that the injection needle moves to the top of the first sample rack accordingly, and then drops to extract the sample liquid in the sample tube on the first sample rack. When multiple solid phase extractions are required, the injection needle can also move to the top of the second sample rack, and then drop to extract the sample liquid in the sample tube on the second sample rack. The sample liquid extracted by the injection needle enters the injection pump, and the SPE The column tray is located above the second sample rack, and the sample liquid in the injection pump can be discharged through the column rod, and then pass through the SPE column on the SPE column tray. When passing through the column, the second sample rack is moved to move the corresponding sample tube on it to the bottom of the SPE column, so as to receive the extract after passing through the column. When the user needs to concentrate the extract by nitrogen blowing, a nitrogen blowing module and a water bath are installed, and the nitrogen blowing drive assembly can drive the nitrogen blowing needle downward to insert into the sample tube containing the extract, and the nitrogen blowing needle blows out nitrogen, and then cooperates with the water bath heating of the water bath to concentrate the extract by nitrogen blowing. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 It is a schematic diagram of the protective shell of the present invention;

[0024] Figure 2 It is a schematic diagram of the three-dimensional structure of the present invention;

[0025] Figure 3 It is a schematic diagram of the three-dimensional structure of another direction of the present invention;

[0026] Figure 4 It is a schematic diagram of the three-dimensional structure of the first sample holder of the present invention;

[0027] Figure 5is a schematic diagram of the three-dimensional structure of a second sample holder of the present invention;

[0028] Figure 6 It is a schematic diagram of the three-dimensional structure of the injection needle of the present invention moving to the top of the second sample rack;

[0029] Figure 7 It is a schematic diagram of the three-dimensional structure of the injection needle of the present invention moving to the top of the first sample rack;

[0030] Figure 8 It is a schematic diagram of the three-dimensional structure of the injection needle drive assembly of the present invention;

[0031] Fig. 9 It is a schematic diagram of the exploded structure of the injection needle drive assembly of the present invention;

[0032] Fig.10 It is a schematic diagram of the three-dimensional structure of the gun head removal mechanism of the present invention;

[0033] Fig.11 For the present invention Fig.10 A partial enlarged view of the middle A;

[0034] Fig.12 It is a schematic diagram of the three-dimensional structure of the column plate driving assembly and the column rod driving assembly of the present invention;

[0035] Fig.13 It is a three-dimensional structural schematic diagram of the column plate driving assembly and the column rod driving assembly of the present invention from another direction;

[0036] Fig.14 For the present invention Fig.13 A partial enlarged view of point B in the middle;

[0037] Fig.15 It is a schematic diagram of the three-dimensional structure of the nitrogen blowing driving mechanism of the present invention;

[0038] Fig.16 It is a schematic diagram of the gas and liquid circuit connection of the present invention;

[0039] Fig.17 It is a structural schematic diagram of the switching valve in the first valve position;

[0040] Fig.18 It is a structural schematic diagram of the switching valve in the second valve position;

[0041] Fig.19 It is a structural schematic diagram of the switching valve when it is in the third valve position;

[0042] Fig. 20 It is a structural schematic diagram of the switching valve when it is in the fourth valve position.

[0043] Explanation of the reference numerals: 1-bottom plate, 2-first sample rack, 3-second sample rack, 4-first sample rack drive assembly, 5-second sample rack drive assembly, 6-injection needle drive assembly, 7-injection needle, 8-SPE column plate, 9-column plate drive assembly, 10-column plug rod, 11-column plug rod drive assembly, 12-nitrogen blow needle, 13-nitrogen blow drive assembly, 14-switching valve, 15-syringe pump, 16-SPE column, 17-cleaning tank, 18-gun head, 19-gun head removal mechanism, 20-gun head removal plate, 21-gun head removal plate drive mechanism, 22-gun head removal port , 23-gun head insertion section, 24-gun head removal section, 25-injection needle crossbeam, 26-injection needle support plate, 27-injection needle left and right drive mechanism, 28-injection needle mounting bracket, 29-injection needle lifting drive mechanism, 30-column plate door frame, 31-column plate drive mechanism, 32-column plug rod support frame, 33-column plug rod mounting bracket, 34-column plug rod drive mechanism, 35-nitrogen blowing support longitudinal plate, 36-nitrogen blowing support horizontal plate, 37-nitrogen blowing drive mechanism, 38-gas distribution device, 39-water bath, 40-protective shell, 41-injection port, 42-sampling port, 4 3-inspection window, 44-injection motor, 45-injection screw nut pair, 46-collection motor, 47-collection screw nut pair, 48-crossbeam support column, 49-injection needle left and right movement motor, 50-injection needle left and right movement active pulley, 51-injection needle left and right movement driven pulley, 52-injection needle left and right movement synchronous belt, 53-injection needle lifting motor, 54-injection needle lifting screw nut pair, 55-column plate drive motor, 56-gear, 57-rack, 58-column rod drive motor, 59-column rod lifting screw nut pair, 60-nitrogen blow drive Motor, 61-nitrogen blowing drive screw nut pair, 62-fixed plate, 63-injection needle lifting synchronous belt transmission mechanism, 64-first sample rack placement table, 65-second sample rack placement table, 66-plug, 67-solvent supply module, 68-injection needle cleaning tank, 69-fixed valve port, 70-switching valve port, 71-first flow path, 72-second flow path, 73-first switching valve port, 74-second switching valve port, 75-third switching valve port, 76-fourth switching valve port, 77-fifth switching valve port, 78-sixth switching valve port, 79-nitrogen blowing module. DETAILED DESCRIPTION

[0044] The present invention is described in detail below with reference to the accompanying drawings and specific embodiments.

[0045] The present invention provides a fully automatic solid phase extractor with optional nitrogen blowing, such as Figure 1-20 As shown, the focus here is on Figure 1 , Figure 2As shown, it includes a base plate 1, a first sample rack placement table 64, a second sample rack placement table 65, a first sample rack drive assembly 4, a second sample rack drive assembly 5, an injection needle drive assembly 6, an injection needle 7, an SPE column plate 8, a column plate drive assembly 9, a column plug rod 10, a column plug rod drive assembly 11, a gas distribution device 38, and a detachably arranged nitrogen blowing module 79. When the user has a nitrogen blowing concentration requirement after solid phase extraction, the nitrogen blowing module 79 can be expanded and installed to automatically perform nitrogen blowing concentration after solid phase extraction;

[0046] The first sample rack placement table 64 is provided with a sample needle cleaning groove 68 for inserting and cleaning the sample needle 7. The sample needle 7, the column rod 10, the sample needle cleaning groove 68, and the gas distribution device 38 are connected to a switching valve 14. The switching valve 14 is also connected to an injection pump 15, a plug 66, and a solvent supply module 67 for supplying solvent. Specifically, in this embodiment, a fixed valve port 69 is provided in the center of the switching valve 14, and six switching valve ports 70 are provided in an outer circumferential array. The fixed valve port 69 is connected to the injection pump 15, and the six switching valve ports 70 are connected to the column rod 10, the gas distribution device 38, the sample needle in turn in a counterclockwise direction. A cleaning tank 68, a solvent supply module 67, a plug 66, and an injection needle 7, wherein the plug 66 is used to block the switching valve port 70. A first flow path 71 and a second flow path 72 are provided in the switching valve 14. The first flow path 71 switches the fixed valve port 69 to connect to one of the switching valve ports 70, and the second flow path 72 switches to connect to two adjacent switching valve ports 70. The two switching valve ports 70 connected by the second flow path 72 are adjacent to the switching valve ports 70 connected by the first flow path 71, and the two switching valve ports 70 connected by the second flow path 72 are located in the counterclockwise direction of the switching valve port 70 connected by the first flow path 71.

[0047] A protective shell 40 is buckled on the top of the bottom plate 1, and the first sample rack placement table 64, the second sample rack placement table 65, the first sample rack drive assembly 4, the second sample rack drive assembly 5, the injection needle drive assembly 6, the injection needle 7, the SPE column plate 8, the column plate drive assembly 9, the column plug rod 10, the column plug rod drive assembly 11, and the nitrogen blowing module 79 are all located in the protective shell 40, and the switching valve 14 and the injection pump 15 are also in the protective shell 40 and are located above the first sample rack 2. The protective shell 40 is provided with an inspection window 43 at the position corresponding to the switching valve 14 and the injection pump 15, so that the switching valve 14 and the injection pump 15 can be easily maintained without disassembling the equipment;

[0048] Focus on combination Figure 2-4As shown, the bottom plate 1 falls on the ground or the test bench, and the first sample rack placement platform 64 and the second sample rack placement platform 65 are arranged side by side on the top of the bottom plate 1 and slide forward and backward respectively through linear guide rail pairs. The first sample rack 2 is detachably fixed on the top of the first sample rack placement platform 64, and the second sample rack 3 or the water bath 39 is detachably fixed on the top of the second sample rack placement platform 65. When the water bath 39 is fixed on the top of the second sample rack placement platform 65, the second sample rack 3 falls into the water bath 39, and the water bath 39 is also an optional component. The top surfaces of the first sample rack 2 and the second sample rack 3 are respectively connected to an array with multiple rows of sample tubes. Sample tubes are placed on the first sample rack 2 and the second sample rack 3. The first sample rack 2 and the second sample rack 3 can be removed at any time to facilitate the insertion of sample tubes and the replacement of sample racks of different specifications. When the second sample rack 3 falls into the water bath 39, the sample tubes on the second sample rack 3 can be heated by water bath through the water bath 39 to cooperate with the nitrogen blowing module 79 to accelerate nitrogen blowing concentration. The first sample rack drive component 4 is connected to and drives the first sample rack 2 and the second sample rack 3. The sample rack placement table 64 drives the first sample rack 2 to move forward and backward, and the second sample rack driving component 5 is connected to and drives the second sample rack placement table 65 to drive the second sample rack 3 to move forward and backward. In this embodiment, the first sample rack driving component 4 includes a sample injection motor 44 and a sample injection lead screw nut pair 45. The lead screw of the sample injection lead screw nut pair 45 extends forward and backward under the first sample rack placement table 64. The nut of the sample injection lead screw nut pair 45 is fixed on the first sample rack placement table 64. The sample injection motor 44 is connected to and drives the sample injection lead screw nut pair 45. The lead screw of the mother pair 45 rotates forward or reversely, thereby driving the first sample rack placement table 64 to move forward and backward. The second sample rack drive assembly 5 includes a collection motor 46 and a collection lead screw nut pair 47. The lead screw of the collection lead screw nut pair 47 extends forward and backward below the second sample rack placement table 65. The nut of the collection lead screw nut pair 47 is fixed on the second sample rack placement table 65. The collection motor 46 is connected to and drives the collection lead screw nut pair 47 to rotate forward or reversely, thereby driving the second sample rack placement table 65 to move forward and backward. Figure 1 As shown, a sample inlet 41 and a sample removal port 42 are respectively provided at the front end surface of the protective shell 40 corresponding to the first sample rack 2 and the second sample rack 3 , so as to facilitate taking and placing sample tubes.

[0049] Focus on combination Figure 6-11As shown, the injection needle driving assembly 6 is connected to and drives the injection needle 7 to move left and right and up and down above the first sample rack 2 and the second sample rack 3 to insert or withdraw the sample tube on the first sample rack 2 or the second sample rack 3. In this embodiment, the injection needle 7 is provided with a plurality of injection needles, and the plurality of injection needles 7 are arranged in a row corresponding to a row of the sample tubes. The injection needle driving assembly 6 includes an injection needle beam 25, an injection needle support plate 26, an injection needle left and right driving mechanism 27, an injection needle mounting frame 28, and an injection needle lifting driving mechanism 29. The two ends of the injection needle beam 25 are fixed to the bottom plate 1 through beam support columns 48, and span the first sample rack 2 and the second sample rack 3 from left to right. The injection needle support plate 26 is connected to the bottom plate 1 through a straight beam support column 48. The linear guide pair is connected to the injection needle crossbeam 25 for sliding left and right. The injection needle left and right driving mechanism 27 is arranged between the injection needle crossbeam 25 and the injection needle support plate 26. The injection needle left and right driving mechanism 27 includes an injection needle left and right movement motor 49, an injection needle left and right movement active pulley 50, an injection needle left and right movement driven pulley 51, and an injection needle left and right movement synchronous belt 52. The injection needle left and right movement motor 49 is fixed on the injection needle crossbeam 25. The injection needle left and right movement motor 49 is connected to drive the injection needle left and right movement active pulley 50 to rotate. The injection needle left and right movement driven pulley 51 is parallel to the axis of the injection needle left and right movement active pulley 50, and is rotatably arranged on the injection needle crossbeam 25. The right movement synchronous belt 52 is wound between the active pulley 50 for the left and right movement of the injection needle and the driven pulley 51 for the left and right movement of the injection needle. The injection needle support plate 26 is connected and fixed to the injection needle left and right movement synchronous belt 52, so as to drive the injection needle support plate 26 to move left and right through the injection needle left and right movement motor 49 to rotate forward or reverse; the injection needle mounting frame 28 is longitudinally slidably connected to the injection needle support plate 26 through a linear guide pair, and the injection needle lifting drive mechanism 29 is connected between the injection needle support plate 26 and the injection needle mounting frame 28. The injection needle lifting drive mechanism 29 includes an injection needle lifting motor 53, an injection needle lifting screw nut pair 54, and an injection needle lifting synchronous belt transmission mechanism 63. The lifting motor 53 is fixed on the injection needle support plate 26, the screw of the injection needle lifting screw nut pair 54 extends along the sliding direction of the injection needle mounting frame 28 and is rotatably connected to the injection needle support plate 26, the nut of the injection needle lifting screw nut pair 54 is fixed on the injection needle mounting frame 28, the injection needle lifting motor 53 is connected to the screw of the injection needle lifting screw nut pair 54 through the injection needle lifting synchronous belt transmission mechanism 63 to drive it to rotate, thereby driving the injection needle mounting frame 28 to lift and lower, a plurality of the injection needles 7 are installed on the injection needle mounting frame 28, thereby realizing that the injection needle drive assembly 6 drives the plurality of the injection needles 7 to move synchronously to insert or withdraw a row of the sample tubes;In this embodiment, a gun tip 18 is sleeved on the bottom end of the injection needle 7, and a gun tip removal plate 20 is arranged above the first sample rack 2, and the gun tip removal plate 20 is provided with a gun tip removal port 22 corresponding to each injection needle 7, and the gun tip removal port 22 longitudinally penetrates the gun tip removal plate 20, and the gun tip removal port 22 includes a gun tip insertion section 23 and a gun tip removal section 24 that are adjacent to each other and connected to each other. The gun tip insertion section 23 is used for the gun tip 18 to pass through, and the gun tip removal section 24 is used to block the gun tip 18 downward. In this embodiment, the gun tip removal plate 20 is formed by an opening on the front edge to form the gun tip removal port 22, and the cross-section of the gun tip removal port 22 is a trumpet shape with the opening facing forward. The front section of the gun tip removal port 22 forms the gun tip insertion section 23, and the rear section forms the gun tip removal section 24. The gun tip removal plate driving mechanism 21 is connected to and drives the gun tip removal plate 20 to move forward and backward, so that when the gun tip insertion section 23 is located below the injection needle 7, the gun tip 18 can pass through the gun head plate 20. After the gun head 18 passes through the gun head plate 20 downward, the gun head plate driving mechanism 21 drives the gun head plate 20 to move, so that the gun head section 24 is located above the gun head 18. The injection needle lifting driving mechanism 29 drives the injection needle 7 to rise. The gun head plate 20 blocks the edge of the gun head 18 downward, so that the gun head 18 can be removed from the injection needle 7. Preferably, a fixed plate 62 is fixedly arranged above the gun head plate 20. The fixed plate 62 is connected and fixed to the bottom plate 1. The fixed plate 62 is provided with a through hole for the gun head 18 to pass through at a position opposite to the gun head opening 22. The gun head plate driving mechanism 21 is installed between the gun head plate 20 and the fixed plate 62. The gun head plate driving mechanism 21 can be any linear driving mechanism such as an existing cylinder, so that the gun head plate 20 moves forward and backward relative to the fixed plate 62. ;

[0050] Focus on combination Figure 2 , Figure 12-14As shown, an SPE column 16 is placed on the SPE column disk 8, and a liquid outlet is opened at the bottom of the SPE column 16. This is the prior art and will not be elaborated in detail. The SPE column disk 8 is located above the second sample rack 3, and the column disk drive assembly 9 is connected to and drives the SPE column disk 8 to move forward and backward. The column insertion rod 10 is located above the SPE column disk 8, and the column insertion rod drive assembly 11 is connected to and drives the column insertion rod 10 to descend and insert or ascend and withdraw from the SPE column 16 on the SPE column disk 8. In this embodiment, a plurality of rows of SPE columns 16 are arranged on the SPE column disk 8, and a plurality of column insertion rods 10 are arranged, and the plurality of column insertion rods 10 correspond to The SPE columns 16 are arranged in a row, and the column tray drive assembly 9 includes a column tray door frame 30, a column tray drive mechanism 31, a column insertion rod support frame 32, a column insertion rod mounting frame 33, and a column insertion rod drive mechanism 34. The column tray door frame 30 is fixed on the base plate 1 and spans the second sample rack 3 from left to right. The SPE column tray 8 is connected to the upper end of the column tray door frame 30 by sliding forward and backward through a linear guide pair. The column tray drive mechanism 31 is arranged between the SPE column tray 8 and the column tray door frame 30. The column tray drive mechanism 31 includes a column tray drive motor 55, a rack 57, and a gear 56. The column tray drive motor 55 is fixed to the column tray door frame 30. The rack 57 is fixed at the bottom of the SPE column disk 8 and extends in the front-to-back direction. The gear 56 is meshed with the rack 57 for transmission. The column disk drive motor 55 is connected and drives the gear 56 to rotate to drive the SPE column disk 8 to move forward and backward. The column insertion rod support frame 32 is fixed above the column disk door frame 30. The column insertion rod mounting frame 33 is longitudinally slidably connected to the column insertion rod support frame 32. The column insertion rod driving mechanism 34 is arranged between the column insertion rod mounting frame 33 and the column insertion rod support frame 32. The column insertion rod driving mechanism 34 includes a column insertion rod driving motor 58 and a column insertion rod lifting screw nut pair 59. The screw of the lifting screw nut pair 59 is rotatably set on the column insertion rod support frame 32 and extends longitudinally. The nut of the column insertion rod lifting screw nut pair 59 is fixed on the column insertion rod mounting frame 33. The column insertion rod driving motor 58 is connected to and drives the screw of the column insertion rod screw nut pair 59 to rotate to drive the column insertion rod mounting frame 33 to lift and lower. The column insertion rod 10 is installed on the column insertion rod mounting frame 33, so that the column insertion rod driving assembly 11 drives multiple column insertion rods 10 to insert downward or withdraw upward from a row of SPE columns 16 at the same time; a cleaning groove 17 is provided on the SPE column plate 8 for the column insertion rod 10 to be inserted and cleaned.

[0051] Focus on combination Figure 2 , Fig.15As shown, the nitrogen blowing module 79 is detachably mounted on the base plate 1, and the nitrogen blowing module 79 is arranged side by side with the SPE column disk 8. Specifically in the present embodiment, the nitrogen blowing module 79 is mounted on the rear side of the SPE column disk 8, and the nitrogen blowing module 79 includes a nitrogen blowing needle 12 and a nitrogen blowing driving assembly 13. The nitrogen blowing needle 12 is connected to the gas distribution device 38 so that the nitrogen blowing needle 12 can blow out nitrogen. The nitrogen blowing driving assembly 13 connects and drives the nitrogen blowing needle 12 to descend and insert or ascend and exit the sample tube on the second sample rack 3. The nitrogen blowing needle 12 is provided with multiple rows, and the multiple rows of the nitrogen blowing needles 12 are arranged the same as the multiple rows of sample tubes on the second sample rack 3. The nitrogen blowing driving assembly 13 includes a nitrogen blowing support longitudinal plate 35, a nitrogen blowing support transverse plate 36, and a nitrogen blowing driving mechanism 37. The nitrogen blowing support longitudinal plate 35 is detachably screwed and fixed on the base plate 1 between the first sample rack 2 and the second sample rack 3. The nitrogen blowing support transverse plate 36 is longitudinally slidably connected to one side of the nitrogen blowing support longitudinal plate 35, and the nitrogen blowing drive mechanism 37 is arranged between the nitrogen blowing support longitudinal plate 35 and the nitrogen blowing support transverse plate 36. The nitrogen blowing drive mechanism 37 includes a nitrogen blowing drive motor 60 and a nitrogen blowing drive lead screw nut pair 61. The nitrogen blowing drive motor 60 is fixed on the nitrogen blowing support longitudinal plate 35. The lead screw of the nitrogen blowing drive lead screw nut pair 61 is rotatably arranged on the nitrogen blowing support longitudinal plate 35 and extends longitudinally. The nut of the nitrogen blowing drive lead screw nut pair 61 is fixed on the nitrogen blowing support transverse plate 36. The nitrogen blowing drive motor 60 is connected and drives the lead screw of the nitrogen blowing drive lead screw nut pair 61 to rotate, thereby driving the nitrogen blowing support transverse plate 36 to rise and fall. The nitrogen blowing needle 12 is installed below the nitrogen blowing support transverse plate 36, and the nitrogen blowing drive assembly 13 drives each of the nitrogen blowing needles 12 to move synchronously to insert or withdraw each sample tube on the second sample rack 3.

[0052] Focus on combination Figure 16-20 As shown, the liquid circuit and gas circuit connected by the switching valve 14 are specifically as follows, the six switching valve ports 70 include a first switching valve port 73, a second switching valve port 74, a third switching valve port 75, a fourth switching valve port 76, a fifth switching valve port 77, and a sixth switching valve port 78 arranged in sequence in a counterclockwise direction, the first switching valve port 73 is connected to the column plug 10, the second switching valve port 74 is connected to the gas distribution device 38, the third switching valve port 75 is connected to the injection needle cleaning tank 68, the fourth switching valve port 76 is connected to the solvent supply module 67, the fifth switching valve port 77 is installed with the plug 66, and the sixth switching valve port 78 is connected to the injection needle 7; in this embodiment, a total of four valve positions of the switching valve 14 are used:

[0053] Valve position 1: Focus combination Fig.16 , Fig.17As shown, the first flow path 71 connects the fixed valve port 69 to the fourth switching valve port 76, and the second flow path 72 connects the fifth switching valve port 77 to the sixth switching valve port 78; at this time, the solvent supply module 67 is connected to the injection pump 15, and the solvent supply module 67 can switch to supply multiple solvents, switch the solvent supply module 37, extract the solvent to the injection pump 15, and the injection needle 7 is connected to the plug 66, and the injection needle 7 does not extract the solvent;

[0054] Valve position 2: Focus combination Fig.16 , Fig.18 As shown, the first flow path 71 connects the fixed valve port 69 to the third switching valve port 75, and the second flow path 72 connects the fourth switching valve port 76 to the fifth switching valve port 77; at this time, the injection pump 15 is connected to the injection needle cleaning groove 68, so that the air or residual solvent in the injection pump 15 is discharged to the injection needle cleaning groove 68. If the injection pump 15 has previously sucked in a solvent for cleaning the injection needle 7, the solvent is discharged to the injection needle cleaning groove 68 to clean the injection needle 7, and the solvent supply module 67 is connected to the plug 66, and the solvent supply module 67 does not supply solvent;

[0055] Valve position 3: Focus combination Fig.16 , Fig.19 As shown, the first flow path 71 connects the fixed valve port 69 to the first switching valve port 73, and the second flow path 72 connects the second switching valve port 74 to the third switching valve port 75; at this time, the injection pump 15 is connected to the column plug rod 10, and the solvent sucked into the injection pump 15 is discharged from the column plug rod 10. During the solid phase extraction process, the column plug rod 10 should be inserted into the SPE column 16, so as to realize the activation, elution, and solid phase extraction of the SPE column 16. The gas distribution device 38 is connected to the injection needle cleaning tank 68, and the gas distribution device 38 blows nitrogen into the injection needle cleaning tank 68 to realize the drying of the injection needle 7 that has been cleaned in the injection needle cleaning tank 68;

[0056] Valve position 4: Focus combination Fig.16 , Fig. 20 As shown, the first flow path 71 connects the fixed valve port 69 to the sixth switching valve port 78, and the second flow path 72 connects the first switching valve port 73 to the second switching valve port 74; at this time, the injection pump 15 is connected to the injection needle 7, and the injection needle 7 is inserted into the sample tube to extract the sample liquid in the sample tube, or discharge the solvent pre-extracted by the injection pump 15 into the sample tube through the injection needle 7, and the gas distribution device 38 is connected to the nitrogen blowing needle 12, and nitrogen is blown out through the nitrogen blowing needle 12 to dry the SPE column 16.

[0057] The working process of the present invention is as follows, but not limited to the following process. First, the first sample rack placement table 64 and the second sample rack placement table 65 are slid to the injection port 41 and the sampling port 42 respectively. The first sample rack 2 and the second sample rack 3 with sample tubes placed thereon are placed and fixed on the first sample rack placement table 64 and the second sample rack placement table 65 respectively from the injection port 41 and the sampling port 42. The corresponding SPE column 16 is inserted into the SPE column disk 8, and the corresponding column plug rod 10 is selected and installed on the column plug rod mounting frame 33. The SPE column disk 8 and the column plug rod 10 are moved so that the column plug rod 10 is inserted into a row of the SPE columns 16. The switching valve 14 is switched to the valve position 1, and the corresponding solvent is sucked into the injection pump 15. The switching valve 14 is switched to the valve position 3 again, and the sucked solvent is discharged from the column plug rod 10 to perform the SPE column injection. The sample tubes on the second sample rack 3 are activated, and then the injection needle 7 and the first sample rack 2 are moved to insert the injection needle 7 into a row of sample tubes on the first sample rack 2, and the switching valve 14 is switched to the valve position 4 to absorb the sample liquid in the sample tubes, and then the row of sample tubes on the second sample rack 3 are moved to the bottom of the column plug rod 10, and the switching valve 14 is switched to the valve position 3 to allow the sample liquid to pass through the SPE column 16. The sample liquid after passing through the column flows into the sample tube on the second sample rack 3 below under the action of gravity, and the sample liquid after passing through the column is sucked back from the second sample rack 3 by the injection needle 7. The above column passing process is repeated again to achieve multiple column passing and complete solid phase extraction. When the nitrogen blowing module 79 is selected, the nitrogen blowing needle 12 is inserted into the sample tube on the second sample rack 3 after solid phase extraction, and the nitrogen blowing needle 12 blows out nitrogen to concentrate the sample liquid in the sample tube after solid phase extraction.

[0058] The above description is only a preferred embodiment of the present invention and is not a limitation on the design of this case. Any equivalent changes made based on the design key of this case shall fall within the protection scope of this case.

Claims

1. A fully automatic solid phase extractor with optional nitrogen blowing, characterized in that: The invention comprises a bottom plate (1), a first sample rack placing platform (64), a second sample rack placing platform (65), a first sample rack driving assembly (4), a second sample rack driving assembly (5), a sampling needle driving assembly (6), a sampling needle (7), an SPE column disk (8), a column plug rod (10), and a column plug rod driving assembly (11); the sampling needle (7) and the column plug rod (10) are connected to a switching valve (14); the switching valve (14) is connected to a syringe pump (15); a first sample rack (2) is detachably fixed above the first sample rack placing platform (64); a second sample rack (3) or a water bath (39) is detachably fixed above the second sample rack placing platform (65); when a water bath (39) is fixed above the second sample rack placing platform (65), the second sample rack (3) falls into the water bath (39); sample tubes are placed on the first sample rack (2) and the second sample rack (3); and an SPE column (16) is placed on the SPE column disk (8); The first sample rack placement platform (64) and the second sample rack placement platform (65) are arranged side by side on the left and right sides of the bottom plate (1) and are respectively slidable forward and backward. The first sample rack driving component (4) is connected to and drives the first sample rack placement platform (64) to drive the first sample rack (2) to move forward and backward. The second sample rack driving component (5) is connected to and drives the second sample rack placement platform (65) to drive the second sample rack (3) to move forward and backward. The injection needle drive assembly (6) is connected to and drives the injection needle (7) to move left and right and up and down above the first sample rack (2) and the second sample rack (3) so as to insert or withdraw the sample tube on the first sample rack (2) or the second sample rack (3); The SPE column plate (8) is located above the second sample rack (3), the column insertion rod (10) is located above the SPE column plate (8), and the column insertion rod driving assembly (11) is connected to and drives the column insertion rod (10) to descend and insert or ascend and withdraw the SPE column (16) on the SPE column plate (8); A nitrogen blowing module (79) is detachably mounted on the bottom plate (1), the nitrogen blowing module (79) and the SPE column plate (8) are arranged side by side in front and back, and include a nitrogen blowing needle (12) and a nitrogen blowing drive assembly (13), the nitrogen blowing needle (12) is connected to a gas distribution device (38), and the nitrogen blowing drive assembly (13) is connected to and drives the nitrogen blowing needle (12) to descend and insert into or ascend and withdraw from the sample tube on the second sample rack (3); The injection needle drive assembly (6) comprises an injection needle crossbeam (25), an injection needle support plate (26), an injection needle left-right drive mechanism (27), an injection needle mounting frame (28), and an injection needle lifting drive mechanism (29). The injection needle crossbeam (25) is fixed to the bottom plate (1) and spans the first sample rack (2) and the second sample rack (3) from left to right. The injection needle support plate (26) is slidably connected to the injection needle crossbeam (25) from left to right. The injection needle left-right drive mechanism (29) The injection needle (27) is arranged between the injection needle cross beam (25) and the injection needle support plate (26) to drive the injection needle support plate (26) to move left and right. The injection needle mounting frame (28) is longitudinally slidably connected to the injection needle support plate (26). The injection needle lifting drive mechanism (29) is connected between the injection needle support plate (26) and the injection needle mounting frame (28) to drive the injection needle mounting frame (28) to rise and fall. The injection needle (7) is mounted on the injection needle mounting frame (28).

2. A fully automatic solid phase extractor with optional nitrogen blowing as claimed in claim 1, characterized in that: The switching valve (14) is also connected to a plug (66) and a solvent supply module (67) for supplying solvent, and a sampling needle cleaning groove (68) for inserting the sampling needle (7) is arranged above the first sample rack placement table (64); The switching valve (14) is provided with a fixed valve port (69) in the center, and six switching valve ports (70) are provided in an outer circumferential array. The fixed valve port (69) is connected to the injection pump (15). The six switching valve ports (70) are respectively connected to the column rod (10), the gas distribution device (38), the injection needle cleaning tank (68), the solvent supply module (67), the plug (66), and the injection needle (7). The plug (66) is used to block the switching valve port (70). The switching valve (14) is provided with a first flow path (71) and a second flow path (72). The first flow path (71) switches the fixed valve port (69) to connect to one of the switching valve ports (70), and the second flow path (72) switches to connect to two adjacent switching valve ports (70).

3. A fully automatic solid phase extractor with optional nitrogen blowing as claimed in claim 1, characterized in that: The lower end of the injection needle (7) is sleeved with a gun head (18), and a gun head removal mechanism (19) is also arranged above the bottom plate (1). The gun head removal mechanism (19) includes a gun head removal plate (20) and a gun head removal plate driving mechanism (21). The gun head removal plate (20) is longitudinally penetrated by a gun head removal opening (22), and the gun head removal opening (22) includes a gun head insertion section (23) and a gun head removal section (24) arranged adjacent to each other and connected to each other. The gun head insertion section (23) is used for allowing the gun head (18) to pass through, and the gun head removal section (24) is used to block the gun head (18) downwards. The gun head removal plate driving mechanism (21) is connected to and drives the gun head removal plate (20) to move forward and backward.

4. A fully automatic solid phase extractor with optional nitrogen blowing as claimed in claim 1, characterized in that: The SPE column disk (8) is connected to a column disk drive assembly (9), and the column disk drive assembly (9) is connected to and drives the SPE column disk (8) to move forward and backward so that each column insertion rod (10) is aligned with an SPE column (16) on the SPE column disk (8).

5. A fully automatic solid phase extractor with optional nitrogen blowing as claimed in claim 4, characterized in that: The SPE column plate (8) is provided with a cleaning groove (17) for the column insert rod (10) to be inserted for cleaning.

6. A fully automatic solid phase extractor with optional nitrogen blowing as claimed in claim 4, characterized in that: The column tray driving assembly (9) comprises a column tray door frame (30), a column tray driving mechanism (31), a column insertion rod support frame (32), a column insertion rod mounting frame (33), and a column insertion rod driving mechanism (34); the column tray door frame (30) is fixed on the base plate (1) and spans the second sample rack (3) from left to right; the SPE column tray (8) is slidably connected to the upper end of the column tray door frame (30) in a front-rear manner; the column tray driving mechanism (31) is arranged between the SPE column tray (8) and the column tray door frame ( 30) to drive the SPE column plate (8) to move forward and backward, the column rod support frame (32) is fixed above the column plate door frame (30), the column rod mounting frame (33) is longitudinally slidably connected to the column rod support frame (32), the column rod driving mechanism (34) is arranged between the column rod mounting frame (33) and the column rod support frame (32) to drive the column rod mounting frame (33) to rise and fall, and the column rod (10) is installed on the column rod mounting frame (33); The nitrogen blowing driving assembly (13) comprises a nitrogen blowing supporting longitudinal plate (35), a nitrogen blowing supporting transverse plate (36), and a nitrogen blowing driving mechanism (37). The nitrogen blowing supporting longitudinal plate (35) is fixed on the bottom plate (1) between the first sample rack (2) and the second sample rack (3). The nitrogen blowing supporting transverse plate (36) is longitudinally slidably connected to one side of the nitrogen blowing supporting longitudinal plate (35). The nitrogen blowing driving mechanism (37) is arranged between the nitrogen blowing supporting longitudinal plate (35) and the nitrogen blowing supporting transverse plate (36) to drive the nitrogen blowing supporting transverse plate (36) to rise and fall. The nitrogen blowing needle (12) is installed below the nitrogen blowing supporting transverse plate (36).

7. A fully automatic solid phase extractor with optional nitrogen blowing as claimed in claim 4, characterized in that: A protective shell (40) is buckled on the top of the bottom plate (1); the first sample rack placement table (64), the second sample rack placement table (65), the first sample rack drive assembly (4), the second sample rack drive assembly (5), the injection needle drive assembly (6), the injection needle (7), the SPE column plate (8), the nitrogen blowing needle (12), the column plate drive assembly (9), the column plug rod (10), the column plug rod drive assembly (11), and the nitrogen blowing drive assembly (13) are all located in the protective shell (40); the front end of the protective shell (40) is provided with an injection port (41) and a sampling port (42) at positions corresponding to the first sample rack (2) and the second sample rack (3); the switching valve (14) and the injection pump (15) are in the protective shell (40) and are located above the first sample rack (2); the protective shell (40) is provided with an inspection window at positions corresponding to the switching valve (14) and the injection pump (15).

8. A fully automatic solid phase extractor with optional nitrogen blowing as claimed in claim 4, characterized in that: The top surfaces of the first sample rack (2) and the second sample rack (3) are respectively arrayed with multiple rows of sample tubes, and multiple injection needles (7) are provided, and the multiple injection needles (7) are arranged in a row corresponding to a row of the sample tubes, and the injection needle drive assembly (6) drives the multiple injection needles (7) to move synchronously to insert or withdraw the sample tubes in a row.

9. A fully automatic solid phase extractor with optional nitrogen blowing as claimed in claim 8, characterized in that: The nitrogen blowing needles (12) are arranged in multiple rows, and the multiple rows of nitrogen blowing needles (12) are arranged in the same manner as the multiple rows of sample tubes on the second sample rack (3). The nitrogen blowing drive assembly (13) drives the nitrogen blowing needles (12) to move synchronously to insert or withdraw the sample tubes on the second sample rack (3).

10. A fully automatic solid phase extractor with optional nitrogen blowing as claimed in claim 8, characterized in that: The SPE column plate (8) is provided with a plurality of rows of SPE columns (16), and a plurality of column insertion rods (10) are provided, and the plurality of column insertion rods (10) are arranged in a row corresponding to a row of the SPE columns (16), and the column insertion rod driving assembly (11) drives the plurality of column insertion rods (10) to simultaneously insert downward or withdraw upward a row of the SPE columns (16).

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