A handheld PCR cleaning device

Abstract

The application relates to the technical field of medical devices, and particularly discloses a hand-held PCR cleaning device, which comprises a handle, a driving device and a cleaning head connected in sequence from top to bottom; the driving device comprises a mounting bracket, a driving motor and a transmission mechanism arranged on the mounting bracket; the power input end of the transmission mechanism is connected with the power output end of the driving motor; the power output end of the transmission mechanism is connected with the cleaning head in a detachable mode; an active shell capable of sliding up and down is arranged outside the mounting bracket; the lower end of the active shell is located above the cleaning head; during the downward movement of the active shell, the lower end of the active shell gradually approaches the upper end of the cleaning head; when the active shell continues to move downward after the lower end of the active shell abuts against the upper end of the cleaning head, the active shell can apply a pressure to the cleaning head to separate the cleaning head from the transmission mechanism. The application has high cleaning efficiency and facilitates the quick dismounting of the cleaning part.

Description

Technical Field

[0001] The present invention relates to the technical field related to medical devices, and in particular to a handheld PCR cleaning device. Background Art

[0002] In order to minimize the unacceptable losses caused by different types of virus outbreaks to humans, it is very necessary to detect the relevant viruses as early as possible and take targeted measures. The development of in vitro diagnostic technology provides reliable technical support for early diagnosis of whether the subject is infected. With the emergence of gene amplification schemes discovered and developed by Mullis, molecular diagnosis based on methods such as temperature cycling or constant temperature amplification has become an important method for reliable and highly sensitive detection.

[0003] In in vitro testing of molecular diagnostic types, more and more equipment is pursuing PCR multi-well plate consumables with basically consistent specifications as reaction containers (because the reaction process often requires temperature maintenance, this reaction container can also be called a temperature block, and the wells distributed on the temperature block can be called reaction wells or heating wells), which can include, for example, 8-well plates, 16-well plates, 48-well plates, 96-well plates, 384-well plates, etc.; of course, the most commonly used equipment is real-time fluorescence quantitative PCR, which can simultaneously amplify and quantify specific parts of a given DNA molecule, quantifying DNA after each round of amplification. Two common quantitative methods are the first use of modified DNA oligonucleotide probes that are used with fluorescence properties, and the other is the use of fluorescent dyes that are inserted into double-stranded DNA at a specific time during the amplification cycle to achieve detection. The well plate type consumables used in these devices can usually build a reaction system of several microliters to tens of microliters. At the same time, the well plate type consumables are usually not matched with a consumable cover, so they may be in an open state before use. Different devices are used in different scenarios to achieve the reaction effect; for example, European patent application EP3704223A4 discloses a filter multi-well plate adapter for use with different types of well plate consumables, which can achieve efficient filtration of multiple sample objects that need to be filtered and then add them to the corresponding well positions of the handheld device to achieve the effect of efficient filtration to obtain the detected objects; Korean patent application KR1020190045686A discloses an implementation scheme for a magnetic effect extraction handheld device in conjunction with well plate structure consumables to achieve parallel extraction of different well positions in the multi-well plate and other operations. However, the development of the above-mentioned equipment is all for the parallel processing application of well plate consumables. As mentioned earlier, most instruments do not pay attention to the risks brought by the contamination of the equipment components themselves during use. This will lead to several problems: First, the presence of contamination may cause inaccurate detection in fluorescence detection; second, because the reaction system constructed by most well plate type equipment is very small, the presence of some contaminating impurities may affect the heat transfer characteristics of the system, and thus there is a risk of false negative test results.

[0004] To clean the wells of a PCR temperature block, patent CN 209406897 U discloses a high-throughput PCR amplification instrument heating well cleaning device in the prior art. The device comprises a plate body, a handle on one side of the plate body, and elastic cleaning columns spaced apart on the other side. The spacing of the elastic cleaning columns corresponds to the spacing of the heating wells of the PCR amplification instrument. However, the manual structure results in low cleaning efficiency and is not convenient for rapid removal and installation of the elastic cleaning columns.

[0005] The above technical problems need to be solved urgently. Summary of the Invention

[0006] In view of this, an object of the present invention is to provide a handheld PCR cleaning device, which has high cleaning efficiency and facilitates the rapid disassembly of the cleaning part.

[0007] To achieve the above object, the present invention provides a handheld PCR cleaning device, which includes a handle, a drive device and a cleaning head connected in sequence from top to bottom;

[0008] The driving device includes a mounting bracket, a driving motor and a transmission mechanism provided on the mounting bracket, the power input end of the transmission mechanism is connected to the power output end of the driving motor, and the power output end of the transmission mechanism is detachably connected to the cleaning head;

[0009] The outer movable sleeve of the mounting bracket is provided with a movable shell that can slide up and down, and the lower end of the movable shell is located above the cleaning head; during the downward movement of the movable shell, the lower end of the movable shell gradually approaches the upper end of the cleaning head, and when the movable shell continues to move downward after its lower end abuts against the upper end of the cleaning head, it can apply pressure to the cleaning head to disengage the transmission mechanism.

[0010] As a further improvement to the technical solution of the present invention, the mounting bracket is connected to the movable shell through a limiting structure, and the limiting structure is also used to limit the moving path of the movable shell; and an elastic reset member is provided between the mounting bracket and the movable shell, and the elastic reset member is used to drive the movable shell to return to its original position when it is not under stress.

[0011] As a further improvement to the technical solution of the present invention, the limiting structure includes a plurality of slide grooves provided on the mounting bracket and a slider provided on the inner side wall of the movable shell corresponding to the slide grooves; the elastic reset member is a compression spring structure and is provided in at least one of the slide grooves.

[0012] As a further improvement to the technical solution of the present invention, the lower part of the handle is rotatably connected to an auxiliary handle, and the top surface of the movable shell is protruded with a protrusion with an inclined surface. During the rotation process, the lower end of the auxiliary handle slides along the inclined surface of the protrusion and applies downward pressure to the movable shell.

[0013] As a further improvement to the technical solution of the present invention, the cleaning head includes a rod body with a straight rod structure, the top end of the rod body is connected to a rod cap, and the bottom end is connected to a rod base, the rod base is in the shape of a cone or a truncated cone with a larger top and a smaller bottom, and the outer surface of the rod base is provided with a liquid absorbing sleeve that can absorb liquid, and the shape of the liquid absorbing sleeve is adapted to the shape of the rod base;

[0014] The transmission mechanism includes a transmission gear, a transmission shaft and a connecting rod; the transmission gear is connected to the rotating shaft of the driving motor and is driven to rotate by the driving motor, and the transmission gear and the connecting rod are connected through the transmission shaft, so that the torque of the rotating shaft is transmitted to the connecting rod; the lower end of the connecting rod is connected to the upper end of the rod cap.

[0015] As a further improvement to the technical solution of the present invention, a through hole is provided at the bottom end of the movable housing, and the aperture of the through hole is larger than the diameter of the connecting rod and smaller than the diameter of the rod cap.

[0016] As a further improvement to the technical solution of the present invention, the number of the cleaning heads is at least two, and the cleaning heads are arranged parallel to each other and are driven to rotate by the same drive motor.

[0017] As a further improvement to the technical solution of the present invention, the device further includes a carrier and / or a protective cover detachably connected to the carrier, and the carrier is provided with a plurality of accommodating slots for vertically positioning the cleaning head.

[0018] As a further improvement to the technical solution of the present invention, the device further includes a cleaning liquid storage box, a diversion pipe and / or a diversion control unit for controlling the on / off flow of the cleaning liquid flow channel, wherein the inner cavity of the cleaning liquid storage box is used to store the cleaning liquid;

[0019] The lower part of the cleaning liquid storage box passes through the avoidance port provided on the movable shell and is fixedly connected to the mounting bracket; one end of the guide tube is connected to the inner cavity of the cleaning liquid storage box, and the other end is used to guide the cleaning liquid to the liquid suction sleeve at the lower end of the cleaning head.

[0020] As a further improvement to the technical solution of the present invention, the guide tube is a capillary structure; a buffer cylinder is fixed to the mounting bracket below the cleaning liquid storage box, the inner cavity of the cleaning liquid storage box is connected to the inner cavity of the buffer cylinder, and the guide tube is connected to the inner cavity of the cleaning liquid storage box through the buffer cylinder;

[0021] An extrusion block is provided at the lower portion of the movable shell; the buffer cylinder is made entirely or partially of a deformable material, and the extrusion block can apply deformation pressure to the deformable portion of the buffer cylinder when moving downward with the movable shell.

[0022] Compared with the prior art, the present invention has the following beneficial technical effects:

[0023] The present invention provides a handheld PCR cleaning device, in which the transmission mechanism can transmit the power of the driving motor to the cleaning head, thereby driving the cleaning head and the PCR temperature block holes to be cleaned to generate relative movement, thereby cleaning the corresponding holes; obviously, compared with manual cleaning, this electric cleaning has a higher cleaning efficiency; in addition, the movable shell movably arranged outside the mounting bracket can not only serve as a protective shell of the driving device, but also can drive the cleaning head out of the transmission mechanism by movement, thereby facilitating the rapid disassembly of the cleaning part.

[0024] Additional advantages of the present invention will be given in the detailed description, and in part will be obvious from the description of the detailed description, or will be learned through practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] The accompanying drawings, which constitute a part of the present invention, are used to provide a further understanding of the present invention. The exemplary embodiments of the present invention and their description are used to explain the present invention but do not constitute a limitation of the present invention.

[0026] Figure 1 A three-dimensional diagram of a handheld PCR cleaning device provided in Example 1 of the present invention;

[0027] Figure 2 This is a diagram showing the use status of a handheld PCR cleaning device provided in Example 1 of the present invention;

[0028] Figure 3 A three-dimensional diagram of a carrier frame of a handheld PCR cleaning device provided in Example 1 of the present invention;

[0029] Figure 4 A diagram showing the use status of a carrier frame of a handheld PCR cleaning device provided in Example 1 of the present invention;

[0030] Figure 5 A diagram showing the use of a handheld PCR cleaning device provided in Example 2 of the present invention;

[0031] Figure 6 A three-dimensional diagram of a handheld PCR cleaning device provided in Example 3 of the present invention;

[0032] Figure 7 A first stereoscopic view of a mounting bracket for a handheld PCR cleaning device provided in Example 3 of the present invention;

[0033] Figure 8 A second perspective view of a mounting bracket for a handheld PCR cleaning device provided in Example 3 of the present invention;

[0034] Figure 9 A perspective view of a driving device of a handheld PCR cleaning device provided in Example 3 of the present invention;

[0035] Figure 10 for Figure 9 Enlarged view of point A in the middle. DETAILED DESCRIPTION

[0036] To make the objectives, technical solutions, and advantages of the embodiments of the present application more clear, the technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the accompanying drawings of the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Generally, the components of the embodiments of the present application described and shown in the drawings herein can be arranged and designed in various different configurations.

[0037] Therefore, the following detailed description of the embodiments of the present application provided in the accompanying drawings is not intended to limit the scope of the present application for protection, but merely represents selected embodiments of the present application. All other embodiments obtained by persons of ordinary skill in the art based on the embodiments in the present application without creative work are within the scope of protection of the present application.

[0038] Example 1

[0039] like Figures 1 to 3 As shown, the present embodiment provides a handheld PCR cleaning device that can clean the PCR temperature block before it is used for PCR amplification reaction or after it has been used for a period of time, thereby reducing the risk of contamination of the corresponding wells in the temperature block; the device includes a top-down ("up" and "down" with Figure 2 The handle 10, the drive device and a cleaning head are connected in sequence.

[0040] The handle 10 is used for the user (ie, the experimental operator) to hold and use. The specific shape of the handle 10 can be determined according to the needs, except for the following: Figure 1 In addition to the "J" shape shown, the handle 10 can be formed into other types to enable the user to hold the device in the most comfortable holding posture, thereby ensuring that the operator can hold the device for a long time for cleaning.

[0041] The handle 10 may be provided with a number of functional buttons 101 for controlling the drive device or other electronically controlled components. The specific locations of the buttons 101 may be determined as needed and are not limited to the positions shown. Alternatively, when using AC power, a power connection port may be provided on the handle 10. When using batteries, a battery mounting slot may be provided within the handle 10, and a charging port may be provided on the handle 10. In this manner, the handle 10 and the drive device are mechanically connected while also being electrically connected.

[0042] The drive device may include a mounting bracket 304, a drive motor (not shown) mounted on the mounting bracket 304, and a transmission mechanism. The power input of the transmission mechanism is connected to the power output of the drive motor, and the power output of the transmission mechanism is detachably connected to the cleaning head. The mounting bracket 304 is used to mount the drive and transmission components of the drive device; the transmission mechanism is used to transmit the power of the drive motor to the cleaning head, thereby driving relative movement between the cleaning head and the PCR block wells 200 to be cleaned, thereby cleaning the corresponding wells 200. Obviously, compared to manual cleaning, this electric cleaning method has higher cleaning efficiency.

[0043] The mounting bracket 304 is movably sleeved with a movable outer shell 30 that can slide up and down, and the lower end of the movable outer shell 30 is located above the cleaning head; during the downward movement of the movable outer shell 30, the lower end of the movable outer shell 30 gradually approaches the upper end of the cleaning head. When the movable outer shell 30 continues to move downward after its lower end abuts against the upper end of the cleaning head, it can apply pressure to the cleaning head to disengage the transmission mechanism.

[0044] The lower end of the handle 10 passes through the top of the movable shell 30 and is connected to the mounting bracket 304; the movable shell 30 not only serves as a protective shell for the drive device, but also can drive the cleaning head out of the transmission mechanism by moving, thereby facilitating the quick disassembly of the cleaning part (the cleaning head in this application).

[0045] In this embodiment, the lower portion of the handle 10 is rotatably connected to an auxiliary handle 20. The top surface of the movable housing 30 is provided with a protrusion 310 having an inclined surface. During rotation, the lower end of the auxiliary handle 20 slides along the inclined surface of the protrusion 310 and applies downward pressure to the movable housing 30. The auxiliary handle 20 can be mounted to the handle 10 in a hinged manner to form a lever-like structure, and a reset torsion spring can be provided between the auxiliary handle 20 and the handle 10. The inclined surface of the protrusion 310 gradually points upward along the rotation direction of the auxiliary handle 20. During rotation, the auxiliary handle 20 presses against the inclined surface, thereby causing the movable housing 30 to move downward, thereby driving the cleaning head out of the transmission mechanism. The user can press the auxiliary handle 20 with the same hand while holding the handle 10, making operation extremely convenient.

[0046] In this embodiment, the cleaning head comprises a straight rod body 40, with a cap 401 attached to the top and a base 402 attached to the bottom. The base 402 is conical (or truncated) in shape, with a larger top and smaller bottom. A liquid-absorbing pipette sleeve 50 is mounted on the outer surface of the base 402. The shape of the pipette sleeve 50 matches that of the base 402. The base 402 is shaped to match the shape of the PCR block well 200, thereby improving the cleaning effect of the well 200. The pipette sleeve 50 is a replaceable cleaning consumable material with porous and water-absorbing properties. For example, it can be formed from a sponge, cotton, linen, chemical fiber, or similar fiber. After being properly soaked with a cleaning solution, it can improve the cleaning effect of the well 200. The rod body 40, cap 401, and base 402 are preferably an integrally formed structure. Specifically, the base 402 and pipette sleeve 50 can be pre-connected during use to ensure quick and efficient replacement of the cleaning head.

[0047] In which, the transmission mechanism may include a transmission gear 301, a transmission shaft 302 and a connecting rod 303; the transmission gear 301 is connected to the rotating shaft of the driving motor and is driven to rotate by the driving motor, and the transmission gear 301 and the connecting rod 303 are connected through the transmission shaft 302, so that the torque of the rotating shaft is transmitted to the connecting rod 303; the lower end of the connecting rod 303 is connected to the upper end of the rod cap 401. The transmission gear 301 can be directly connected to the rotating shaft of the driving motor or connected through other gear parts; the transmission shaft 302 is fixed to the shaft hole of the transmission gear 301; the transmission shaft 302 and the connecting rod 303 are coaxially arranged and rotate synchronously; the connecting rod 303 and the rod cap 401 are preferably connected by an interference fit, that is, the diameter of the connecting rod 303 is slightly larger than the diameter of the positioning groove on the rod cap 401, so that the rod cap 401 can be quickly disconnected from the connecting rod 303 when subjected to downward force; of course, a radial limiter can also be provided between the connecting rod 303 and the positioning groove to ensure the smooth rotation of the cleaning head.

[0048] In this embodiment, the bottom end of the movable housing 30 is provided with a through hole 305. The diameter of the through hole 305 is larger than the diameter of the connecting rod 303 and smaller than the diameter of the rod cap 401. With this structure, as the through hole 305 moves downward, the connecting rod 303 remains stationary, while the bottom end of the movable housing 30 gradually approaches the rod cap 401. After abutting the rod cap 401, the movable housing 30 continues to move downward, exerting downward pressure on the rod cap 401.

[0049] In addition, in order to facilitate the rapid replacement of the cleaning head, the device may also include a carrier 62, on which are distributed several accommodating grooves 63 for vertically positioning the cleaning head; an adaptive protective cover 61 may be provided on the carrier 62, and the protective cover 61 is detachably connected to the carrier 62; after the protective cover 61 is connected to the carrier 62, the space therein is isolated from the outside world, thereby keeping the cleaning head therein clean.

[0050] Example 2

[0051] The handheld PCR cleaning device provided in this embodiment can be obtained by improving the cleaning device shown in the first embodiment, so the same structures and technical effects are not described here in detail.

[0052] This embodiment provides a handheld PCR cleaning device. To meet the cleaning needs of the porous structure of the PCR temperature block, the number of cleaning heads is at least two, and the cleaning heads are arranged parallel to each other and are driven to rotate by the same drive motor.

[0053] like Figure 5 As shown, the number of cleaning heads can be eight, and the eight cleaning heads are arranged in parallel in the horizontal direction, and the distance between adjacent cleaning heads is equal; the eight cleaning heads are driven to rotate by a driving motor. At this time, each cleaning head can be corresponding to a set of transmission mechanisms, and the transmission mechanisms are arranged in parallel, and the transmission gears 301 of each transmission mechanism can be engaged in sequence, so that the eight cleaning heads can rotate simultaneously; of course, other suitable transmission structures can also be used; the number of through holes 305 at the bottom end of the movable shell 30 is consistent with the number of cleaning heads.

[0054] Example 3

[0055] The handheld PCR cleaning device provided in this embodiment can be obtained by improving the cleaning device shown in the first or second embodiment, so the same structures and technical effects will not be described here.

[0056] This embodiment provides a handheld PCR cleaning device, which also includes a cleaning liquid storage box 70 and a diversion tube 702. The inner cavity of the cleaning liquid storage box 70 is used to store the cleaning liquid. The cleaning liquid can contain alcohol-based sterilization components to eliminate potential contamination risks. Of course, it can also contain some surfactants and other components. In addition, in order to control the flow of the cleaning liquid, the device can also be provided with a diversion control unit (not shown in the figure) for controlling the on-off of the cleaning liquid flow channel. The diversion control unit can, for example, be a solenoid valve or other suitable structure.

[0057] The lower portion of the cleaning liquid storage box 70 passes through the avoidance opening 340 provided on the movable housing 30 and is fixedly connected to the mounting bracket 304; one end of the diversion tube 702 is connected to the inner cavity of the cleaning liquid storage box 70, and the other end is used to divert the cleaning liquid to the liquid suction sleeve 50 at the lower end of the cleaning head. The provision of the avoidance opening 340 ensures that the cleaning liquid storage box 70 and the movable housing 30 do not interfere with each other during movement; the cleaning liquid storage box 70 can be connected to the mounting bracket 304, for example, via a connector 330; the other end of the diversion tube 702 can abut against the connecting rod 303, and the cleaning liquid flowing out of this end can flow along the connecting rod 303 to the cleaning head. Of course, this diversion operation is performed when the driving device is stopped; in addition, a dedicated flow channel 3031 can be provided on the connecting rod 303, as long as it can divert the cleaning liquid to the liquid suction sleeve 50.

[0058] In this embodiment, the guide tube 702 is a capillary structure; a buffer cylinder 701 is fixed on the mounting bracket 304 below the cleaning liquid storage box 70, the inner cavity of the cleaning liquid storage box 70 is connected to the inner cavity of the buffer cylinder 701, and the guide tube 702 is connected to the inner cavity of the cleaning liquid storage box 70 through the buffer cylinder 701. The guide tube 702 adopts a capillary structure. Due to its small diameter, the flow resistance of the cleaning liquid is large. Even if the guide control part is not provided, the cleaning liquid cannot flow smoothly under the action of gravity alone. In this case, the cleaning liquid storage box 70 is connected to the buffer cylinder 701 through the water supply port 703, and the lower part 320 of the movable shell 30 is provided with an extrusion block 3201; the buffer cylinder 701 is made of deformable material in whole or in part, and the extrusion block 3201 can apply deformation pressure to the deformable part of the buffer cylinder 701 when it moves downward with the movable shell 30, that is, by applying a downward force to the movable shell 30, the movable shell 30 moves downward (this movement does not cause the movable shell 30 to contact the cleaning head) and drives the extrusion block 3201 to move. The extrusion block 3201 squeezes the buffer cylinder 701, causing the buffer cylinder 701 to deform (the volume of the inner cavity changes) and provide pressure for the flow of the cleaning liquid.

[0059] In this embodiment, the mounting bracket 304 is connected to the movable housing 30 via a limiting structure. The limiting structure is also used to limit the movement path of the movable housing 30, that is, to limit the movable housing 30 to sliding only in the upward and downward directions, thereby effectively preventing the movable housing 30 from moving in an unordered manner. An elastic return member 90 is provided between the mounting bracket 304 and the movable housing 30. The elastic return member 90 is used to drive the movable housing 30 to return to its original position when it is not under force. The elastic return member 90 provides an upward return force for the movable housing 30. When the movable housing 30 moves downward, it needs to overcome the elastic force of the elastic return member 90, so that the movable housing 30 can quickly return to its original position after the external force is eliminated. Specifically, the limiting structure may include a plurality of slide grooves 80 provided on the mounting bracket 304 and a slider (not shown) provided on the inner side wall of the movable housing 30 corresponding to the slide grooves 80. The elastic return member 90 is a compression spring structure and is provided in at least one of the slide grooves 80.

[0060] Finally, it should be noted that this article uses specific examples to illustrate the principles and implementation methods of the present invention. The description of the above embodiments is only used to help understand the core idea of ​​the present invention. Without departing from the principles of the present invention, the present invention can also be improved and modified in several ways, and these improvements and modifications also fall within the scope of protection of the present invention.

Claims

1. A handheld PCR cleaning device, characterized by: The device comprises a handle, a driving device and a cleaning head connected in sequence from top to bottom; The driving device includes a mounting bracket, a driving motor and a transmission mechanism provided on the mounting bracket, the power input end of the transmission mechanism is connected to the power output end of the driving motor, and the power output end of the transmission mechanism is detachably connected to the cleaning head; The outer sleeve of the mounting bracket is provided with a movable housing that can slide up and down, and the lower end of the movable housing is located above the cleaning head; during the downward movement of the movable housing, the lower end of the movable housing gradually approaches the upper end of the cleaning head, and when the movable housing continues to move downward after the lower end thereof abuts against the upper end of the cleaning head, pressure can be applied to the cleaning head to disengage the transmission mechanism; The device further comprises a carrier and / or a protective cover detachably connected to the carrier, wherein the carrier is provided with a plurality of receiving slots for vertically positioning the cleaning heads; The device further comprises a cleaning liquid storage box, a flow guide tube and / or a flow guide control unit for controlling the on / off of a flow channel for the cleaning liquid, wherein the inner cavity of the cleaning liquid storage box is used to store the cleaning liquid; The lower portion of the cleaning liquid storage box passes through the avoidance opening provided on the movable shell and is fixedly connected to the mounting bracket; one end of the guide tube is connected to the inner cavity of the cleaning liquid storage box, and the other end is used to guide the cleaning liquid to the liquid suction sleeve at the lower end of the cleaning head; The guide tube is a capillary structure; a buffer cylinder is fixed on the mounting bracket below the cleaning liquid storage box, the inner cavity of the cleaning liquid storage box is connected to the inner cavity of the buffer cylinder, and the guide tube is connected to the inner cavity of the cleaning liquid storage box through the buffer cylinder; An extrusion block is provided at the lower portion of the movable shell; the buffer cylinder is made entirely or partially of a deformable material, and the extrusion block can apply deformation pressure to the deformable portion of the buffer cylinder when moving downward with the movable shell.

2. A handheld PCR cleaning device according to claim 1, characterized in that: The mounting bracket is connected to the movable housing through a limiting structure, and the limiting structure is also used to limit the movement path of the movable housing; and an elastic reset member is provided between the mounting bracket and the movable housing, and the elastic reset member is used to drive the movable housing to return to its original position when it is not under stress.

3. The handheld PCR cleaning device according to claim 2, characterized in that: The limiting structure includes a plurality of slide grooves arranged on the mounting bracket and sliders arranged on the inner side wall of the movable shell corresponding to the slide grooves; the elastic reset member is a compression spring structure and is arranged in at least one of the slide grooves.

4. The handheld PCR cleaning device according to claim 2, characterized in that: The lower part of the handle is rotatably connected to an auxiliary handle, and the top surface of the movable shell is convexly provided with a convex block with an inclined surface. During the rotation process, the lower end of the auxiliary handle slides along the inclined surface of the convex block and applies downward pressure to the movable shell.

5. The handheld PCR cleaning device according to claim 1, characterized in that: The cleaning head comprises a rod body of a straight rod structure, the top end of the rod body is connected to a rod cap, and the bottom end is connected to a rod base, the rod base is in the shape of a cone or a truncated cone with a larger top and a smaller bottom, and the outer surface of the rod base is covered with a liquid absorbing sleeve that can absorb liquid, and the shape of the liquid absorbing sleeve is adapted to the shape of the rod base; The transmission mechanism includes a transmission gear, a transmission shaft and a connecting rod; the transmission gear is connected to the rotating shaft of the driving motor and is driven to rotate by the driving motor, and the transmission gear and the connecting rod are connected through the transmission shaft, so that the torque of the rotating shaft is transmitted to the connecting rod; the lower end of the connecting rod is connected to the upper end of the rod cap.

6. The handheld PCR cleaning device according to claim 5, characterized in that: A through hole is provided at the bottom end of the movable housing, and the diameter of the through hole is larger than the diameter of the connecting rod and smaller than the diameter of the rod cap.

7. A handheld PCR cleaning device according to any one of claims 1 to 6, characterized in that: The number of the cleaning heads is at least two, and the cleaning heads are arranged parallel to each other and are driven to rotate by the same driving motor.

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