Oral care compositions

Abstract

The present invention relates to oral care compositions. An oral care composition is provided, comprising from about 0.01% to about 40% of a persulfate whitening agent and from about 1% to about 99% of a non-aqueous dispersant. The oral care composition of the present invention has, for example, whitening properties and stability.

Description

[0001] This application is a divisional application of a Chinese patent application filed on November 16, 2016, with application number "201680090846.6" and invention name "Oral Care Composition". Technical Field

[0002] The present invention relates to oral care compositions. Background Art

[0003] Oral care products with teeth whitening properties use a variety of active ingredients to remove stains or whiten teeth. The most commonly used whitening active ingredient is a peroxide, such as hydrogen peroxide. However, in high concentrations, hydrogen peroxide can irritate teeth and gums, and is an unstable molecule that is prone to decomposition, especially in aqueous environments.

[0004] Alternative oxidizing agents such as persulfate or persulfate salts have been used as detergents. However, these oxidizing agents have limited use in oral care compositions due to their high reactivity and instability in aqueous solutions.

[0005]

[0006] Therefore, there is a need for oral care compositions that utilize stable non-peroxide hydrogen oxidizing agents such as persulfate or persulfate salts. Summary of the invention

[0006] The present invention is intended only to introduce a simplified overview of some aspects of one or more embodiments of the present disclosure. Other applicable fields of the present invention will become apparent from the specific embodiments provided below. The present invention is not intended to be an exhaustive overview, nor is it intended to identify the key or important elements of this teaching, nor is it intended to delimit the scope of the present disclosure. In fact, its purpose is only to provide one or more simplified forms of concepts as a preface to the following specific embodiments.

[0007] The foregoing and / or other aspects and utilities embodied in the present disclosure can be achieved by providing an oral care composition comprising: from about 0.01% to about 40% of a persulfate whitening agent, based on the total weight of the oral care composition; and from about 1% to about 99% of a non-aqueous dispersant, based on the total weight of the oral care composition.

[0008] In another embodiment, the persulfate whitening agent comprises potassium permonosulfate.

[0009] In another embodiment, the non-aqueous dispersion comprises a liquid or paste poloxamer.

[0010] In another embodiment, the liquid poloxamer comprises polyoxyethylene-polyoxypropylene glycol.

[0011] In another embodiment, the non-aqueous dispersant comprises polyethylene glycol.

[0012] In another embodiment, the non-aqueous dispersant comprises a polyethylene glycol / polypropylene glycol copolymer.

[0013] In another embodiment, the oral care composition further comprises from about 1% to about 60% of a structure building agent, based on the total weight of the oral care composition.

[0014] In another embodiment, the structure building agent comprises a cross-linked polymer.

[0015] In another embodiment, the structure building agent comprises cross-linked polyvinylpyrrolidone (PVP).

[0016] In another embodiment, the oral care composition comprises from about 0.01% to about 40% MPS as a persulfate whitening agent; from about 1% to about 99% liquid poloxamer as a non-aqueous dispersant; and from about 1% to about 60% PVP as a structure building agent.

[0017] In another embodiment, the liquid poloxamer comprises polyoxyethylene-polyoxypropylene glycol.

[0018] In another embodiment, the oral care composition has a viscosity of about 50,000 to about 500,000 cPs.

[0019] In another embodiment, the active oxygen content of the oral care composition after aging for 8 weeks at 40°C is greater than about 70% of the initial active oxygen content of the oral care composition.

[0020] In another embodiment, the active oxygen content of the oral care composition after aging for 13 weeks at 40°C is greater than about 70% of the initial active oxygen content of the oral care composition.

[0021] In another embodiment, the oral care further comprises at least one of a surfactant, a thickener, an antioxidant, a flavoring agent, a sweetener, a pH adjuster, an abrasive, an anticalculus agent, a fluoride ion source, a stannous ion source, a colorant, and a dye or pigment.

[0022] In another embodiment, all ingredients are orally acceptable and the oral care composition comprises from about 0.2 to about 10% of a persulfate whitening agent; from about 10% to 40% of a structure building agent; and from about 20% to about 60% of a non-aqueous or low moisture dispersant, wherein the structure building agent comprises cross-linked polyvinyl pyrrolidone (PVP), wherein the non-aqueous or low moisture dispersant comprises polyoxyethylene-polyoxypropylene glycol, and wherein the moisture range of the oral care composition is about 5% or less.

[0023] In another embodiment, the oral care composition does not contain a hydrogen peroxide compound.

[0024] In another embodiment, the oral care composition is a dentifrice.

[0025] The foregoing and / or other aspects and utilities embodied in the present disclosure may also be achieved by providing a method for whitening a tooth surface, the method comprising applying an oral care composition to a tooth surface; activating the oral care composition by exposing the oral care composition to water or saliva; and wherein the oral care composition comprises: from about 0.01% to about 40% of a persulfate whitening agent, based on the total weight of the oral care composition; and from about 1% to about 99% of a non-aqueous dispersant, based on the total weight of the oral care composition.

[0026] In another embodiment, the viscosity of the oral care composition is from about 50,000 cPs to about 500,000 cPs, and the oral care composition comprises from about 0.01% to about 40% MPS as a persulfate whitening agent; from about 1% to about 99% liquid poloxamer as a non-aqueous dispersant; and from about 1% to about 60% PVP as a structure building agent.

[0027] The foregoing and / or other aspects and utilities embodied in the present disclosure can be achieved by providing an oral care composition substantially as described above with reference to the Examples and excluding the Comparative Examples, if any. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] The accompanying drawings, which are incorporated into and constitute a part of this specification, illustrate embodiments of the present teaching. These and / or other aspects and advantages of the embodiments of the present disclosure will become apparent and more easily understood through the following description of various embodiments in conjunction with the accompanying drawings, in which:

[0029] Figure 1 is a graph illustrating the whitening efficacy of an oral care composition according to one embodiment.

[0030] These diagrams / graphs are intended to be illustrative and not limiting. DETAILED DESCRIPTION

[0031] Reference will now be made specifically to various embodiments in the present disclosure, examples of which are illustrated in the accompanying drawings. Embodiments are described below to provide a more comprehensive understanding of the components, methods, compositions and equipment disclosed herein. Any examples given are intended to be illustrative, not restrictive. However, it will be apparent to one of ordinary skill in the art that the present invention can be practiced without these specific details. In other cases, well-known methods, procedures and components have not been described in detail in order to unnecessarily obscure aspects of the embodiments.

[0032] Throughout the specification, unless the context clearly specifies otherwise, the following terms take the meanings clearly associated herein. As used herein, the phrases "in some embodiments" and "in one embodiment" do not necessarily refer to the same embodiment, although they may be the same. In addition, the phrases "in another embodiment" and "in some other embodiments" as used herein do not necessarily refer to different embodiments, although they may be different. As described below, various embodiments may be easily combined without departing from the scope or essence of the present disclosure.

[0033] As used herein, unless the context clearly dictates otherwise, the term "or" is an inclusive operator and is equivalent to the term "and / or". Unless the context clearly dictates otherwise, the term "based on" is not exclusive and allows for being based on additional factors that are not described. In the specification, the recitation of "at least one of A, B, and C" includes embodiments containing: A, B, or C; multiple instances of A, B, or C; or combinations of A / B, A / C, B / C, A / B / B / B / B / C, A / B / C, etc. In addition, throughout the specification, the meanings of "one", "a", and "the" include plural referents. The meaning of "in" includes "in" and "on".

[0034] It should also be understood that, although the terms first, second, etc. can be used to describe various elements in this article, these elements should not be limited by these terms. These terms are only used to distinguish one element from another element. For example, without departing from the scope of the present invention, the first object, component or step can be referred to as the second object, component or step, and, similarly, the second object, component or step can be referred to as the first object, component or step. The first object, component or step and the second object, component or step are objects, components or steps respectively, but they should not be regarded as the same object, component or step. It should be further understood that, when used in this specification, the term "inclueds / including" and / or "comprises / comprising" specifies the existence of stated features, steps, operations, elements and / or components, but does not exclude the existence or addition of one or more other features, steps, operations, elements, components and / or their groups. In addition, as used herein, the term "if" can be understood to mean "when ... "or "at ... "or "in response to determination ... "or "in response to detection ... ", depending on the context.

[0035] Unless otherwise stated, all physical properties defined below are measured at 20°C to 25°C.

[0036] When any numerical range is mentioned herein, such range is understood to include every number and / or fraction between the minimum and maximum values ​​of the range, as well as the endpoints. For example, a range of 0.5-6% explicitly includes all intermediate values, e.g., 0.6%, 0.7%, and 0.9%, up to and including 5.95%, 5.97%, and 5.99%, etc. Unless the context clearly dictates otherwise, the same applies to each other numerical property and / or element range set forth herein.

[0037] Unless otherwise indicated, all percentages and amounts expressed herein and elsewhere in the specification should be understood to refer to percentages by weight. The amounts given are based on the effective weight of the material.

[0038] In addition, all numerical values ​​are "about" or "approximately" indicated values, and take into account experimental errors and deviations that would be expected by a person of ordinary skill in the art. It should be understood that all numerical values ​​and ranges disclosed herein are approximate values ​​and ranges, regardless of whether "about" is used in conjunction with them.

[0039] With respect to procedures, methods, techniques, and workflows according to certain embodiments, some operations in the procedures, methods, techniques, and workflows disclosed herein may be combined and / or the order of some operations may be changed.

[0040] The present inventors have unexpectedly discovered a stable oral care composition using persulfate or a persulfate salt as a tooth whitening agent.

[0041] In one embodiment, the oral care composition comprises acids and salts of peroxy derivative compounds selected from 6A, 5A, 4A and 7A main group elements (e.g., sulfur, phosphorus, carbon, chlorine, bromine and iodine). For example, in one embodiment, the oral care composition may use peroxydisulfates, peroxydiphosphates and peroxydicarbonates as tooth whitening agents. In another embodiment, the oral care composition comprises potassium peroxymonosulfate ("MPS") as a tooth whitening agent.

[0042] In one embodiment, the oral care composition comprises a whitening agent and a dispersant. In another embodiment, the oral care composition comprises a whitening agent, a dispersant, and a structure building agent.

[0043] In some embodiments, the oral care composition may include other ingredients commonly used in oral care compositions, such as thickeners, flavoring agents, tartar control agents, surfactants, sweeteners, humectants, colorants, dyes, and pigments.

[0044] All ingredients used in the compositions described herein should be orally acceptable. "Orally acceptable" means that the ingredients are present in the composition in amounts and forms that do not render the formulation unsafe, unpalatable, or otherwise unsuitable for use in the oral cavity.

[0045] As described above, the oral care composition comprises one or more whitening agents. As used herein, a "whitening agent" is a material that whitens the tooth surface to which it is applied. For example, in some embodiments, the whitening agent is an oxidizing agent. In the broadest sense, "oxidizing agent" is intended to include those compounds that can accept electrons from another molecule in the oral environment during normal and recognized use without harmful or unacceptable detrimental effects on the oral cavity.

[0046] In one embodiment, the whitening agent can be any suitable salt of persulfate, including permonosulfate and peroxydisulfate, such as potassium peroxymonosulfate and sodium peroxymonosulfate, or a mixture of such salts. An example of a particularly useful whitening agent is a triple salt mixture comprising potassium peroxymonosulfate, potassium hydrogen sulfate and potassium sulfate. Optionally, such a mixture may also contain potassium peroxydisulfate. An example of such a commercially available mixture is "OXONE", which is the trade name of a mixture sold by DuPont, headquartered in Wilmington, Delaware. Another example is CAROAT, obtained from United Initiators, headquartered in Pullach, Germany. OXONE consists of 43% potassium peroxymonosulfate, 23% potassium hydrogen sulfate, 29% potassium sulfate, 3% potassium peroxydisulfate and 2% magnesium carbonate. Mixtures of these potassium reagents are generally available in powder or solid form, and when dissolved in water, generally form highly acidic solutions (e.g., pH 1-4) that are fairly stable during storage. For example, a 1-3% OXONE solution has a pH of 2.0-2.3. However, at pH above 6, these mixtures are strong oxidants that readily decompose to release reactive oxygen species. Many sources use the term "potassium peroxymonosulfate" or "potassium peroxymonosulfate" to refer to the above-mentioned triple salt mixture containing OXONE (2KHSO5-KHSO4-K2SO4). However, as used herein, the terms "potassium peroxymonosulfate", "potassium peroxymonosulfate" and "MPS" refer to individual chemical species having the formula KHSO5.

[0047] In some embodiments, the whitening agent is a non-hydrogen peroxide whitening agent.In some embodiments, the oral care composition does not comprise hydrogen peroxide.

[0048] In some embodiments, one or more additional whitening agents may be present to enhance the effectiveness of the persulfate whitening agent. Such additional whitening agents may include peroxides and hydroperoxides, such as hydrogen peroxide, alkali metal and alkaline earth metal peroxides, organic peroxy compounds, peroxy acids, their salts and their mixtures. Alkali metal and alkaline earth metal peroxides include lithium peroxide, potassium peroxide, sodium peroxide, magnesium peroxide, calcium peroxide, barium peroxide and their mixtures. Organic peroxy compounds include urea peroxide, urea peroxide (also known as urea hydrogen peroxide), glyceryl hydroperoxide, alkyl hydroperoxides, dialkyl peroxides, alkyl peroxy acids, peroxy esters, diacyl peroxides, benzoyl peroxide and monoperoxyphthalate and their mixtures. Peroxyacids and salts thereof include organic peroxyacids such as alkyl peroxyacids, monoperoxyphthalates and mixtures thereof, and inorganic peroxyacid salts such as percarbonates, perphosphates, perborates and persilicates of alkali metals and alkaline earth metals such as lithium, potassium, sodium, magnesium, calcium and barium and mixtures thereof. In some embodiments, non-peroxide whitening agents may be provided. Whitening agents that may be used herein include non-peroxy compounds such as chlorine dioxide, chlorites and hypochlorites. Chlorites and hypochlorites include those chlorites and hypochlorites of alkali metals and alkaline earth metals such as lithium, potassium, sodium, magnesium, calcium and barium. Non-peroxide whitening agents also include colorants such as titanium dioxide and hydroxyapatite.

[0049] In one embodiment, the whitening agent has a stronger whitening effect than hydrogen peroxide. In another embodiment, the whitening agent has a stronger whitening effect than hydrogen peroxide even at the same level of active oxygen.

[0050] In one embodiment, the oral care composition comprises one or more whitening agents. For example, based on the total weight of the oral care composition, the oral care composition may comprise from about 0.01% to about 40% of a persulfate whitening agent. In another embodiment, the oral care composition comprises from about 0.1% to about 20% of a persulfate whitening agent. In yet another embodiment, the oral care composition comprises from about 0.2% to about 10% of a persulfate whitening agent. For example, in one embodiment, the oral care composition comprises from about 0.01% to about 40% of MPS, from about 0.1% to about 20% of MPS, or from about 0.2% to about 10% of MPS. In one embodiment, based on the total weight of the oral care composition, the oral care composition comprises 0.5% of MPS.

[0051] According to embodiments of the present disclosure, the oral care composition comprises one or more dispersants.

[0052] In one embodiment, the whitening agent is initially in powder or solid form and is dispersed by a dispersant to form the oral care composition.

[0053] Although MPS is somewhat unstable in aqueous solution at acidic pH as disclosed in the present disclosure, MPS is more stable in the solid state or in non-aqueous formulations and is most active as an oxidizing agent (and tooth whitening agent) in aqueous solution at a pH of 5 to 8. Thus, in some embodiments, the dispersant is non-aqueous and is used to stabilize the whitening agent in the oral care composition.

[0054] In one embodiment, the dispersant is non-aqueous, but the dispersant is sufficiently hydrophilic to react in an aqueous environment (e.g., oral cavity) to release the whitening agent. The released whitening agent, such as MPS, will dissolve and activate in an aqueous environment. In other embodiments, the oral care composition is activated when exposed to water outside the oral cavity.

[0055] In one embodiment, the oral care composition is non-aqueous, such that the moisture content of the oral care composition is in the range of about 5% or less.

[0056] In one embodiment, the dispersant is a poloxamer. In some embodiments, the dispersant is a liquid or paste poloxamer having an average molecular weight of less than 7000 Daltons. For example, the dispersant may include L35, L43, L64, L10, L44, L62, 10R5, 17R4, L25R4, P84, P65, P104 and One or more of P105. HYDRADE(R) brand dispersants are commercially available from BASF, Florham Park, NJ.

[0057] In other embodiments, in addition to the poloxamer, the oral care composition further comprises an additional non-aqueous dispersant or a suitable low water content dispersant. For example, in some embodiments, the oral care composition may comprise one or more of polyethylene glycols such as PEG400 and PEG600, or polyethylene glycol / polypropylene glycol copolymers such as PEG / PPG 38 / 8 and PEG / PPG-116 / 66.

[0058] In one embodiment, the oral care composition comprises from about 1% to about 99% of a non-aqueous dispersant, based on the total weight of the oral care composition. In another embodiment, the oral care composition comprises from about 10% to about 80% of a non-aqueous dispersant. In yet another embodiment, the oral care composition comprises from about 20% to about 60% of a non-aqueous dispersant. For example, in one embodiment, the oral care composition comprises from about 5% to about 99% of L35, from about 10% to about 80% of L35, or from about 20% to about 60% of L35.

[0059] In various embodiments, the oral care composition may include more than one dispersant. For example, the oral care composition may include about 5% to about 90% of poloxamer; about 0.1% to about 50% of polyethylene glycol; and 0.1% to about 50% of polyethylene glycol / polypropylene glycol copolymer. In another embodiment, the oral care composition may include about 10% to about 60% of poloxamer; about 1% to about 40% of polyethylene glycol; and about 1% to about 40% of polyethylene glycol / polypropylene glycol copolymer. In yet another embodiment, the oral care composition may include about 15% to about 50% of poloxamer; about 2% to about 30% of polyethylene glycol; and about 2% to about 30% of polyethylene glycol / polypropylene glycol copolymer. For example, the oral care composition may include about 15% to about 50% of L35, about 2% to about 30% of PEG 600, and about 2% to about 30% of PEG / PPG-116 / 66.

[0060] Generally, viscosity is an important parameter of oral care compositions such as toothpaste or whitening gel. For example, when the viscosity of oral care compositions is too low, it may become too easy to flow and physical phase separation may occur. In some cases, this will not only affect the aesthetics of the oral care compositions, but also affect the uniformity of the composition in the oral care compositions. On the other hand, if the viscosity of the oral care compositions is too high, the oral care compositions will be difficult to manufacture and package. In addition, oral care compositions with high viscosity are very difficult to be discharged from conventional packaging (such as pipe or syringe). Therefore, it is very important to select the composition of the oral care compositions with the desired viscosity range to ensure the manufacturability, stability and quality of the product and the acceptance of consumers.

[0061] In some embodiments, the viscosity of the oral care composition is from about 50,000 centipoise (cPs) to about 500,000 cPs at 25° C. In other embodiments, the viscosity of the oral care composition is from about 75,000 cPs to about 400,000 cPs at 25° C. In one embodiment, the viscosity of the oral care composition is from about 125,000 cPs to about 300,000 cPs at 25° C.

[0062] In some embodiments, the oral care compositions comprise one or more structure building agents.

[0063] As used herein, the term structure building agent refers to a material that can not only thicken the oral care composition, but also maintain the oral care composition in a homogeneous state. That is, a material that minimizes phase separation over time. While not being bound by theory, the structure building agent typically interacts with the dispersant via hydrogen bonding and / or van der Waals interactions.

[0064] In some embodiments, the structure building agent can be a polymer. In other embodiments, the structure building agent is a cross-linked polymer, such as cross-linked polyvinyl pyrrolidone ("PVP"). In one embodiment, the structure building agent is a cross-linked polymer that can interact with a dispersant. For example, in some embodiments, the cross-linked PVP swells in the presence of L35 by absorbing L35 into its cross-linked polymer network. This interaction helps prevent the solid (cross-linked PVP) from phase separation with the liquid (L35) in the oral care composition.

[0065] According to some embodiments, suitable structure building agent polymers and copolymers include N-vinyl lactam-based polymers and copolymers. Monomers used to prepare vinyl lactam-based polymers or copolymers of the present patent application include any monomers having 3 to 8 atoms in the heterocyclic ring, the monomers containing carbonyl carbon atoms and heteroatoms (e.g., N, S, O) in their vinyl moieties. Suitable monomers include, but are not limited to, N-vinyl-2-pyrrolidone, N-vinyl-2-piperidone, N-vinyl-3-methyl-pyrrolidone, N-vinyl-3-methyl-piperidone, N-vinyl-3-methyl-caprolactam, N-vinyl-4-methyl-pyrrolidone, N-vinyl-4-methyl-2-pyrrolidone, N-vinyl-4-methyl-piperidone, N-vinyl-4-methyl-caprolactam, N-vinyl-5-methyl-pyrrolidone, N-vinyl-5-ethyl-2-pyrrolidone, N-vinyl-4-methyl-piperidone, N-vinyl-3-ethyl-pyrrolidone, N-vinyl-4,5-dimethyl-pyrrolidone, N-vinyl-5,5-dimethyl-pyrrolidone, N-vinyl-3,3,5-trimethyl-pyrrolidone, N-vinyl-5-methyl-5-ethyl -pyrrolidone, N-vinyl-3,4,5-trimethyl-3-ethyl-pyrrolidone, N-vinyl-6-methyl-2-piperidone, N-vinyl-6-ethyl-2-piperidone, N-vinyl-3,5-dimethyl-2-piperidone, N-vinyl-4,4-dimethyl-2-piperidone, N-vinyl-2-caprolactam, N-vinyl-7-methyl-caprolactam, N-vinyl-7-ethyl-caprolactam, N-vinyl-3,5-dimethyl-caprolactam, N-vinyl-4,6-dimethyl-caprolactam, N-vinyl-3,5,7-trimethyl-caprolactam, N-vinyl-2-valerolactam, N-vinyl-hexahydro-2-azepinone, N-vinyl-octahydro-2-azacyclooctanone, N-vinyloctahydro-2-azacyclononanone and N-vinyldecahydro-2-azacyclodecanone.

[0066] The polymer may be a cross-linked polyvinyl pyrrolidone, also known as poly-N-vinyl-poly-2-pyrrolidone, and often abbreviated as cross-linked "PVP". PVP generally refers to a polymer containing vinyl pyrrolidone (also known as N-vinyl pyrrolidone, N-vinyl-2-pyrrolidone, and N-vinyl-2-pyrrolidinone) as a monomer unit. The monomer unit may contain a polar imide group, four non-polar methylene groups, and a non-polar methane group. Cross-linked PVP includes PVP sold by BASF, Mount Olive, NJ, USA, as and Those commercially available; and those sold by Ashland, Covington, Kentucky, USA INF-10.

[0067] In one embodiment, the oral care composition comprises from about 1% to about 60% of a structure builder, based on the total weight of the oral care composition. In another embodiment, the oral care composition comprises from about 5% to about 50% of a structure builder. In yet another embodiment, the oral care composition comprises from about 10% to about 40% of a structure builder. For example, in one embodiment, the oral care composition comprises from about 1% to about 60% PVP, from about 5% to about 50% PVP, or from about 10% to about 40% PVP. In one example, the oral care composition comprises 23% PVP, based on the total weight of the oral care composition.

[0068] As mentioned above, in some embodiments, the oral care composition may include other ingredients commonly used in oral care compositions, such as thickeners, flavoring agents, tartar control agents, surfactants, sweeteners, humectants, colorants, dyes and pigments. In some embodiments, the oral care composition may include other ingredients commonly used by most oral care compositions that are acceptable. However, in some embodiments, in view of the requirement to maintain a non-aqueous or substantially non-aqueous oral care composition, it is necessary to select additional ingredients acceptable to the oral cavity. For example, in some embodiments, additional ingredients will not affect the non-aqueous nature of the oral care composition.

[0069] In one embodiment, the oral care composition comprises one or more surfactants. In some embodiments, the surfactant enhances the stability of the composition, helps to clean the oral surface by the detergency, and provides foam when agitated (e.g., during brushing with the oral care composition of the present disclosure). The surfactant is generally used to achieve increased whitening effect by fully dispersing the whitening agent throughout the oral cavity. In various embodiments, suitable surfactants can be used as surfactants, emulsifiers and / or foam regulators.

[0070] Any orally acceptable surfactant may be used, most of which are anionic, nonionic, cationic or zwitterionic. Combinations of surfactants may also be used. Suitable anionic surfactants include, but are not limited to, C 8-20 Alkyl sulfate, sulfonated C 8-20Water-soluble salts of fatty acid monoglycerides, sarcosinates, taurates, etc. Illustrative examples of these and other types include sodium lauryl sulfate, sodium coconut oil monoglyceride sulfonate, sodium lauryl sarcosinate, sodium lauryl isoethionate, sodium laurethcarboxylate, and sodium dodecylbenzenesulfonate. Suitable nonionic surfactants include, but are not limited to, poloxamers, polyoxyethylene sorbitan esters, fatty alcohol ethoxylates, alkylphenol ethoxylates, tertiary amine oxides, tertiary phosphine oxides, dialkyl sulfoxides, and the like. Suitable zwitterionic surfactants include, but are not limited to, C-1-6-1 ... 8-20 Derivatives of secondary and tertiary aliphatic amines. A suitable example is cocamidopropyl betaine.

[0071] In some embodiments, the oral care composition comprises from about 0.01% to about 20.0% of a surfactant, based on the total weight of the oral care composition. In other embodiments, the oral care composition comprises from about 1.0% to about 10.0% of a surfactant. In one embodiment, the oral care composition comprises 2% of a surfactant, based on the total weight of the oral care composition. For example, the oral care composition may comprise about 2% sodium lauryl sulfate.

[0072] In some embodiments, the oral care composition comprises a thickener. Any orally acceptable thickener may be used, including but not limited to carbomer (also known as carboxyvinyl polymer), carrageenan (also known as Irish moss and more specifically carrageenan (iota-carrageenan)), high molecular weight polyethylene glycol (e.g., CARBOWAX TM , available from The Dow Chemical Company), cellulose polymers (e.g., hydroxyethylcellulose, carboxymethylcellulose (CMC) and its salts such as sodium CMC), natural gums (e.g., gum karaya, xanthan gum, gum arabic and gum tragacanth), colloidal magnesium aluminum silicate, colloidal or fumed silica, and mixtures thereof. The thickener may be a combination of one or more orally acceptable thickeners.

[0073] In some embodiments, the oral care composition comprises from about 0.1% to about 90% thickener, based on the total weight of the oral care composition. In other embodiments, the oral care composition comprises from about 0.2% to about 50% thickener. In yet another embodiment, the oral care composition comprises from about 0.5% to about 35% thickener, based on the total weight of the oral care composition. For example, the oral care composition may comprise about 2.3% fumed silica.

[0074] In some embodiments, the oral care composition comprises an antioxidant. Acceptable antioxidants include BHA, BHT, vitamin A, carotenoids, vitamin E, flavonoids, polyphenols, ascorbic acid, herbal antioxidants, chlorophyll, melatonin, and mixtures thereof. In some embodiments, the oral care composition comprises from about 0.001% to about 1% antioxidant based on the total weight of the oral care composition. In one embodiment, the oral care composition comprises about 0.03% by weight antioxidant.

[0075] According to one embodiment, oral care composition comprises one or more flavoring agents.Available flavoring agent comprises any material or material mixture that can be operated to enhance the taste of oral care composition.Any acceptable natural or synthetic flavoring agent of oral cavity can be used, such as flavoring oil, flavoring aldehyde, ester, alcohol, similar material and their combination.Flavoring agent comprises vanillin, sage, marjoram, parsley oil, spearmint oil, cinnamon oil, wintergreen oil (methyl salicylate), peppermint oil, clove oil, laurel oil, anise oil, eucalyptus oil, citrus oil, fruit oil and fruit essence (including those derived from lemon, orange, sour orange, grapefruit, apricot, banana, grape, apple, strawberry, cherry, pineapple etc.), flavoring agent (such as coffee, cocoa, cola nut, peanut, almond) etc. derived from beans and nuts, adsorbed and encapsulated flavoring agent and their mixture.Also encompassed within the flavoring agent of this article is the composition that provides fragrance and / or other sensory effects (including cool or warming effect) in oral cavity. Such ingredients include menthol, menthyl acetate, menthyl lactate, camphor, eucalyptus oil, eucalyptol, anethole, eugenol, cinnamon, oxanone, x-ionone, propenyl guaiethol, thymol, linalool, benzaldehyde, cinnamaldehyde, N-ethyl-p-menthane-3-carboxamide, N,2,3-trimethyl-2-isopropylbutanamide, 3-1-menthoxypropane-1,2-diol, cinnamaldehyde glycerol acetal (CGA), menthone glycerol acetal (MGA) and mixtures thereof.

[0076] In some embodiments, the oral care composition comprises from about 0.01% to about 5% of a flavoring agent, based on the total weight of the oral care composition. In another embodiment, the oral care composition comprises from about 0.05% to about 2% of a flavoring agent. In yet another embodiment, the oral care composition comprises from about 0.1% to about 3%, from about 0.2% to about 2.5%, or about 1.5% of a flavoring agent, based on the total weight of the oral care composition. For example, the oral care composition may comprise about 1.5% of a toothpaste flavoring agent.

[0077] In some embodiments, the oral care composition may also include one or more sweeteners. Sweeteners that can be used herein include natural or artificial, nutritional or non-nutritive sweeteners that are acceptable to the oral cavity. Such sweeteners include dextrose, polydextrose, sucrose, maltose, dextrin, dry invert sugar, mannose, xylose, ribose, fructose, levulose, galactose, corn syrup (including high fructose corn syrup and corn syrup solids), partially hydrolyzed starch, hydrogenated starch hydrolysate, sorbitol, mannitol, xylitol, maltitol, isomalt, aspartame, neotame, saccharin and its salt, sucralose, strong sweeteners based on dipeptides, cyclamate, dihydrochalcone and their mixtures. Some embodiments may include one or more sweeteners. In some embodiments, based on the gross weight of the oral care composition, the oral care composition includes about 0.005% to about 5% sweetener. In other embodiments, the oral care composition comprises from about 0.01% to about 1% of a sweetener.For example, the oral care composition may comprise about 0.5% sodium saccharin and about 0.04% sucralose.

[0078] In some embodiments, the oral care composition may also include one or more pH adjusting agents. The pH adjusting agents that can be used herein include acidulants that reduce pH, alkalizers that increase pH, and buffers that control pH within the desired range. For example, one or more compounds selected from acidulants, alkalizers, and buffers may be included to provide a pH of 2 to 10, or about 2 to about 8, about 3 to about 9, about 4 to about 8, about 5 to about 7, about 6 to about 10, and about 7 to about 9 in various embodiments. Any acceptable pH adjusting agent for oral cavity may be used, including but not limited to carboxylic acid, phosphoric acid, and sulfonic acid, acid salts (e.g., monosodium citrate, disodium citrate, monosodium malate, etc.), alkali metal hydroxides such as sodium hydroxide, carbonates such as sodium carbonate, bicarbonate, sesquicarbonate, borate, silicate, phosphate (e.g., monosodium phosphate, trisodium phosphate, pyrophosphate, etc.), imidazoles, and mixtures thereof. One or more pH adjusting agents are optionally present in a total amount that can effectively maintain the composition within the acceptable pH range for oral cavity. In some embodiments, the oral care composition comprises from about 0.01% to about 10% of a pH adjuster, based on the total weight of the oral care composition. For example, the oral care composition may comprise about 0.9% sodium acid pyrophosphate (SAPP) and about 2% tetrasodium pyrophosphate (TSPP) as pH adjusters.

[0079] In some embodiments, the oral care composition may include a colorant. Colorants such as dyes or pigments may be food color additives currently certified for use in food and ingested drugs under the Food Drug & Cosmetic Act, including dyes such as FD&C Red No. 3 (tetraiodine fluorescein sodium salt), Food Red 17, 6-hydroxy-5-{(2-methoxy-5-methyl-4-thiophenyl)azo}-2-naphthalenesulfonic acid sodium salt, Food Yellow 13, a sodium salt of a mixture of monosulfonic and disulfonic acids of quinophthalone or 2-(2-quinolyl)indanedione, FD&C Yellow No. 5 (4-p-sulfophenylazo-1-p-sulfophenyl-5-hydroxypyrazole-3-carboxylic acid sodium salt), FD&C Yellow No. 6 (p-sulfophenyl Colorants include, but are not limited to, azo-B-naphthol-6-monosulfonic acid sodium salt), FD&C Green No. 3 (4-{[4-(N-ethyl-p-sulfobenzylamino)-phenyl]-(4-hydroxy-2-sulfoniophenyl)-methylene}-[1-(N-ethyl-N-p-sulfobenzyl)-δ-3,5-cyclohexanediimide disodium salt), FD&C Blue No. 1 (dibenzyldiethyl-diamino-triphenylmethanol trisulfonic acid anhydride disodium salt), FD&C Blue No. 2 (indigo disulfonic acid sodium salt), and mixtures thereof in various ratios. Generally, if present, the colorant is present in a very small amount.

[0080] The compositions of the present disclosure may also comprise one or more other active ingredients that are capable of operating to prevent or treat a condition or disorder of the hard or soft tissues of the oral cavity, to prevent or treat a physiological disorder or condition, or to provide a cosmetic benefit.

[0081] Some embodiments of the present disclosure include a combination of tooth abrasives or tooth abrasive agents. As used herein, the term "abrasive" or "abrasive agent" also includes materials that are often referred to as "polishing agents". Any orally acceptable abrasive can be used, but the type, fineness (particle size) and amount of the abrasive should generally be selected so that tooth enamel is not excessively worn during normal use of the composition. Suitable abrasives include, but are not limited to, silica (in the form of silica gel, hydrated silica or precipitated silica), alumina, insoluble phosphates, calcium carbonate, resin abrasives, such as urea-formaldehyde condensation products, etc.

[0082] Insoluble phosphates useful as abrasives include orthophosphates, polymetaphosphates and pyrophosphates. Illustrative examples are dicalcium orthophosphate dihydrate, calcium pyrophosphate, n-calcium pyrophosphate, tricalcium phosphate, calcium polymetaphosphate and insoluble sodium polymetaphosphate.

[0083] If present, the average particle size of the abrasive is generally from about 0.1 to about 100 μm. For example, in one embodiment, the particle size is from about 1 to about 80 μm or from about 5 to about 60 μm. In some embodiments, one or more abrasives are present in an amount of from about 0.01% to about 70% by weight based on the total weight of the oral care composition. In other embodiments, the oral care composition comprises from about 0.1% to about 60% of an abrasive. In some embodiments, the abrasive is calcium pyrophosphate. In some embodiments, the oral care composition comprises from 0.01% to about 70% of calcium pyrophosphate based on the total weight of the oral care composition. In another embodiment, the oral care composition comprises about 20% of calcium pyrophosphate.

[0084] In various embodiments of the present disclosure, the oral care composition includes anticalculus agent. Suitable anticalculus agents include, but are not limited to, phosphates and polyphosphates (e.g., pyrophosphates), polyaminopropanesulfonic acid (AMPS), hexametaphosphate, zinc citrate trihydrate, polypeptides, polyolefin sulfonates, polyolefin phosphates, diphosphonates. In some embodiments, based on the gross weight of the oral care composition, the anticalculus agent is present in an amount of about 0.01% by weight to about 30% by weight. In some embodiments, the oral care composition includes a mixture of anticalculus agents. In some embodiments, tetrasodium pyrophosphate (TSPP) and sodium tripolyphosphate (STPP) are used as anticalculus agents. In some embodiments, the anticalculus agent includes 0.1% to 10% TSPP, or about 2% TSPP.

[0085] Another component of the present composition may be a synthetic anionic polymeric polycarboxylate which acts as a stabilizer for the polyphosphate anticalculus agent and may help block access to the dental nerves by painful or pain-inducing materials such as sugars.

[0086] In some embodiments, the oral care composition optionally includes a fluoride ion source. In some embodiments, the fluoride ion source is selected from: fluoride, monofluorophosphate (MFP) and fluorosilicate. In some embodiments, one or more compounds that release fluoride ions are optionally present in an amount that provides a total of 100 to 20,000ppm, 200 to 5,000ppm or 500 to 2,500ppm of fluoride ions. If present, in some embodiments, based on the total weight of the oral care composition, the amount of the fluoride source in the oral care composition is in the range of about 0.01% by weight to about 10% by weight, typically about 1.1%. For example, in one embodiment, the oral care composition may include about 0.76% MFP.

[0087] The composition may also include stannous ions or stannous ion sources to mitigate calcium loss. Suitable stannous ion sources include, but are not limited to, stannous fluoride, other stannous halides (such as stannous chloride dihydrate), stannous pyrophosphate, organic stannous carboxylates, such as stannous formate, stannous acetate, stannous gluconate, stannous lactate, stannous tartrate, stannous oxalate, stannous malonate and stannous citrate, stannous ethylene glyoxide, etc. In some embodiments, one or more stannous ion sources are included in the oral care composition. For example, based on the gross weight of the oral care composition, the oral care composition may include about 0.01% to about 10% by weight of stannous ion sources. In one embodiment, the oral care composition includes about 0.1% to about 7% of stannous ion sources or about 0.2% to about 5% of stannous ion sources.

[0088] Example

[0089] Various aspects of the present disclosure may be further understood by reference to the following examples. These examples are illustrative and are not intended to limit their embodiments. Table 1 shows an oral care composition according to one embodiment of the present disclosure. Example 1 shows an embodiment of a method of preparing the oral care composition of Table 1.

[0090] Table 1

[0091] Oral Care Composition #1

[0092]

[0093]

[0094] Example 1

[0095] The oral care composition comprising the ingredients listed in Table 1 is prepared as follows: the L35 and other non-aqueous or low-moisture dispersants of the formula amount are added to the Ross mixer and mixed at high speed for 2 minutes without vacuum. Then, the PVP and thickener of the formula amount are added to the Ross mixer. The powder is moistened and the resulting mixture is mixed at maximum speed for 2 minutes under full vacuum. The tooth abrasive, pH regulator, anti-tartar agent, fluoride ion source and sweetener of the formula amount are added to the Ross mixer. The powder is moistened and the resulting mixture is mixed at maximum speed for 2 minutes under full vacuum. Then the surfactant and MPS of the formula amount are added to the Ross mixer, and the resulting mixture is mixed at medium speed under vacuum for 5 minutes. Finally, the flavoring agent of the formula amount is added, the mixture is mixed at medium speed without vacuum, and then mixed for 10 minutes under full vacuum.

[0096] The potential effectiveness of a tooth whitening oral care composition can be measured based on the active oxygen content. For example, the term active oxygen can be related to the amount of peroxide present in the composition. One oxygen in each peroxide group is considered "active". The percentage of active oxygen (AO) in a given composition can be defined by the following formula 1:

[0097] Formula 1

[0098] [AO]% = equivalent weight of AO*MW of AO / sample weight

[0099] In one embodiment, the stability of the oral care composition can be determined by monitoring the change in the level of active oxygen over time. The level of active oxygen can be experimentally obtained by the well-known thiosulfate-based titration method. This method is also commonly used to determine the level of active oxygen in compositions containing hydrogen peroxide.

[0100] The amount of active oxygen in the oral care composition of Table 1 is determined by the active oxygen titration method as follows: About 1.3 grams of the composition of Table 1 is added to a beaker. Then 25 ml of glacial acetic acid is added, followed by 50 ml of ethanol / water (1:1 volume ratio "v / v"). The mixture is then mixed until the composition of Table 1 is completely suspended. 5 ml of 20 wt % potassium iodide solution and 4 drops of ammonium molybdate solution are added to the mixture and mixed for 5 minutes. The mixture turns light yellow. 2 ml of starch indicator is added to the mixture. The mixture turns dark brown. The mixture is then titrated with 0.1 N sodium thiosulfate solution until the dark color disappears and the amount of sodium thiosulfate solution used (mL) is recorded. The percentage of active oxygen (AO%) is then calculated as follows:

[0101] Formula 2

[0102]

[0103] The meq wt of the oxidant is 0.008

[0104] To determine the stability of the oral care compositions, AO% was measured before and after aging at 40°C, as shown in Table 2. The oral care compositions were aged for up to 13 weeks, a time frame typically used to predict a 24 month shelf life under normal conditions. Under normal conditions, maintaining about 70% or more of the initial AO% after 8 weeks is considered a good result and indicates that the composition is sufficiently stable for commercial distribution and sale, and maintaining about 70% or more of the initial AO% after 13 weeks is considered an excellent result.

[0105] Table 2

[0106]

[0107] As shown in Table 2, the oral care composition had an initial AO% drop of about 20% and then remained relatively stable for the remainder of the 13-week accelerated aging study. This result indicates very good stability. In comparison, an unstable oral care composition containing a similar starting concentration of Oxone (Oral Care Composition #2 in Table 3) showed more active oxygen loss under similar aging conditions (Table 4).

[0108] Table 3

[0109] Comparative Oral Care Composition #2

[0110]

[0111]

[0112] Table 4

[0113]

[0114] As mentioned above, in some embodiments, the oral care composition is non-aqueous. In addition, in some other embodiments, the oral care composition should be substantially free of liquid ingredients with high-density hydroxyl groups, such as polyol-type wetting agents, including glycerol, sorbitol, propylene glycol or compounds with similar structural features. Although not bound by theory, it is believed that the composition with high-density hydroxyl groups has a strong tendency to absorb moisture. Because persulfate such as MPS is sensitive to humidity, excessive moisture accumulation in the oral care composition will activate MPS during storage and cause greater active oxygen loss. In addition, the hydroxyl groups in these ingredients can also directly react with whitening agents, thereby further reducing the stability of the oral care composition. These effects are shown in Table 3 to Table 4. As shown in Table 1 and Table 3, oral care composition #1 includes non-aqueous dispersant (L35), and oral care composition #2 includes glycerol and propylene glycol. As shown in Table 2 and Table 4, oral care composition #1 shows a higher stability than oral care composition #2 during storage.

[0115] In some embodiments, the whitening efficiency of the oral care composition disclosed herein is greater than the whitening efficiency of commercially available whitening toothpaste. As used herein, the phrase "whitening efficacy" is intended to refer to the amount of change in tooth color. Color change can be measured according to the L*a*b* color scale. Assuming a* and b* are zero, the lightness or brightness (L*) value measures brightness and varies in the range of values ​​from pure white to zero for black. The a* value is a measure of red when it is a positive value, a measure of gray when it is zero, and a measure of green when it is a negative value. The b* value is a measure of yellow when it is a positive value, a measure of gray when it is zero, and a measure of blue when it is a negative value. Generally, teeth look whiter when the following situations occur: an increase in the L* value means that they become brighter, an increase or decrease in the a* value depends on whether the stained teeth have a green hue or a red hue before whitening, and a reduction in the b* value means that they become less yellow. While this is the general relationship for perceived whitening, if the L* value increases sufficiently, then the b* value may also increase slightly. Similarly, if the b* value decreases sufficiently to mask a less noticeable change in L*, then the L* value may decrease.

[0116] In some embodiments, the whitening index (W*) is used to evaluate the whiteness of teeth. The whiteness index is based on the distance of the color value from the nominal white point, expressed as L*=100, a*=0 and b*=0 in the CIELAB color space, and is defined according to the following formula 3:

[0117] Formula 3

[0118] W*=[(a*) 2 +(b*) 2 +(L*-100) 2 ] 1 / 2 .

[0119] The change in W* can be used to evaluate the whitening efficacy of the composition before and after treatment. The following formula 4 can be used to calculate ΔW*:

[0120] Formula 4

[0121] ΔW*=W*(treated)-W*(baseline).

[0122] Other values ​​that can be used to evaluate tooth whiteness are described in Joiner et al., "A Review of Tooth Colour and Whiteness", Journal of Dentistry, 2008, 36S:S2-S7, which is incorporated herein by reference in its entirety.

[0123] The whitening efficacy of the oral care composition according to the embodiments of the present disclosure was tested using an in vitro brushing study as follows: Artificially stained bovine central incisors mounted in resin were purchased from Dental Product Testing Therametric Technologies, Inc. Only teeth with L* values ​​above 58 and below 64 were selected. The bovine incisors were brushed for 2 minutes at 250 g force using two slurries. One slurry contained 2 g of oral composition #1 and 2 g of artificial saliva. The other slurry contained 2 g of a commercially available whitening toothpaste and 2 g of artificial saliva. The L, a, and b values ​​were measured using a SPECTROSHADE Micro instrument manufactured by Medical High Technology (MHT). The teeth were treated with 14 brushing cycles to simulate a 7-day (day and night) brushing routine. The results of the brushing study are shown in Tables 5 and Figure 1 Medium. The lower the ΔW value, the whiter the teeth.

[0124] Table 5

[0125]

[0126] The commercially available whitening toothpaste used in Table 5 uses a hydrogen peroxide whitening agent. Specifically, based on the total weight of the commercially available whitening toothpaste, the commercially available whitening toothpaste uses 0.55% cross-linked PVP / hydrogen peroxide complex as a whitening agent. Specifically, based on the total weight of the commercially available whitening toothpaste, for a 0.1% HP content, the commercially available whitening toothpaste uses 0.55% cross-linked PVP / hydrogen peroxide complex as a whitening agent.

[0127] As shown in Table 5 and Figure 1 As shown, teeth brushed with oral care composition #1 had lower ΔW values ​​than teeth brushed with a commercial whitening toothpaste. Figure 1 The excellent whitening efficacy of the oral care composition according to the embodiments of the present disclosure was demonstrated. The results also showed the stability of the oral care composition #1. After accelerated aging at 40°C for 13 weeks, the oral care composition #1 had the same whitening performance as when freshly prepared.

[0128] In some embodiments, the present disclosure provides a method for whitening the oral surfaces of a human or animal subject. The method may include contacting the tooth surface with an oral care composition according to an embodiment of the present disclosure. As used herein, "animal subject" includes non-human mammals, such as dogs, cats, and horses. In one embodiment, the oral care composition is contacted with the oral surface of a mammalian subject to whiten teeth in a highly effective manner.

[0129] In various embodiments, the oral care compositions prepared according to the present disclosure can be applied to the oral surfaces regularly, for example, daily, at least once a day for multiple days, or every two or three days. In some embodiments, the oral care compositions are applied to the oral surfaces 1 to 3 times a day for at least 2 weeks to 8 weeks, four months to three years, or longer up to a lifetime.

[0130] In some embodiments, the oral care composition can be embodied as a gel and can be applied directly to the teeth using a delivery device, such as a pen, a liquid stick with an applicator, such as a felt tip, a brush, a rollerball, or a nonwoven pad, in an amount sufficient to produce a whitening effect after activation. In some embodiments, the oral care composition is activated once exposed to the aqueous environment of the oral cavity or when directly exposed to water or saliva. In some embodiments, the oral care composition of the present disclosure remains on the surface of the teeth for multiple minutes.

[0131] In some embodiments, the oral care composition is activated and remains on the surface of the tooth for about 1 minute to about 8 hours. In some embodiments, the composition is activated and remains on the surface of the tooth for about 5 minutes to about 4 hours. In some embodiments, the composition is activated and remains on the surface of the tooth for about 10 minutes to about 120 minutes. In some embodiments, the composition is activated and remains on the surface of the tooth for about 15 minutes to about 60 minutes. In some embodiments, the composition is activated and remains on the surface of the tooth for about 20 minutes to about 45 minutes.

[0132] The present disclosure has been described with reference to exemplary embodiments. Although a limited number of embodiments have been shown and described, it will be appreciated by those skilled in the art that changes may be made to these embodiments without departing from the principles and spirit of the foregoing specific embodiments. The present disclosure is intended to be interpreted as including all such modifications and changes.

Claims

1. An oral care composition comprising: 0.2% to 10% potassium permonosulfate, 1% to 60% polyvinylpyrrolidone, 10% to 60% poloxamer, 1% to 40% polyethylene glycol, and 1% to 40% polyethylene glycol / polypropylene glycol copolymer, based on the total weight of the oral care composition; wherein the polyvinyl pyrrolidone is a cross-linked polyvinyl pyrrolidone, and wherein the moisture range of the oral care composition is 5% or less.

2. The oral care composition according to claim 1, wherein the oral care composition is a toothpaste or a whitening gel.

3. The oral care composition of claim 1, wherein the oral care composition comprises 0.5% potassium permonosulfate, based on the total weight of the oral care composition.

4. The oral care composition of claim 1, wherein the oral care composition comprises 15% to 50% of poloxamer, 2% to 30% of polyethylene glycol, and 2% to 30% of polyethylene glycol / polypropylene glycol copolymer, based on the total weight of the oral care composition.

5. The oral care composition according to claim 4, wherein the oral care composition comprises 15% to 50% of L35, 2% to 30% PEG-600, and 2% to 30% PEG / PPG-116 / 66.

6. The oral care composition of claim 1, wherein the oral care composition comprises 5% to 50% polyvinylpyrrolidone, based on the total weight of the oral care composition.

7. An oral care composition according to any one of claims 1 to 6, wherein the oral care composition further comprises sodium lauryl sulfate.

8. The oral care composition of claim 7, wherein the oral care composition further comprises cocamidopropyl betaine.

9. An oral care composition according to any one of claims 1 to 6, wherein the oral care composition further comprises calcium pyrophosphate.

10. The oral care composition of claim 5, wherein the oral care composition comprises 5% to 50% polyvinylpyrrolidone, based on the total weight of the oral care composition.

11. The oral care composition of claim 10, wherein the oral care composition further comprises sodium lauryl sulfate, cocamidopropyl betaine, and calcium pyrophosphate.

12. The oral care composition according to any one of claims 1 to 6, wherein the viscosity of the oral care composition is 50,000 to 500,000 cPs.

13. The oral care composition of any one of claims 1 to 6, wherein after aging at 40°C for 8 weeks, the active oxygen content of the oral care composition is greater than 70% of the initial active oxygen content of the oral care composition.

14. The oral care composition of claim 13, wherein after aging at 40°C for 13 weeks, the active oxygen content of the oral care composition is greater than 70% of the initial active oxygen content of the oral care composition.

15. The oral care composition according to any one of claims 1 to 6, further comprising at least one of a surfactant, a thickener, an antioxidant, a flavoring agent, a pH adjuster, an abrasive, an anticalculus agent, a fluoride ion source, a stannous ion source, and a colorant.

16. An oral care composition according to any one of claims 1 to 6, wherein the oral care composition does not comprise a hydrogen peroxide compound.

17. A non-therapeutic method for whitening tooth surfaces, comprising: applying an oral care composition according to any one of claims 1 to 6 to the tooth surface; as well as The oral care composition is activated by exposing the oral care composition to water or saliva.

18. A non-therapeutic method for whitening tooth surfaces, comprising: applying the oral care composition according to claim 10 to the tooth surface; as well as The oral care composition is activated by exposing the oral care composition to water or saliva.

19. A non-therapeutic method for whitening tooth surfaces, comprising: applying the oral care composition according to claim 11 to the tooth surface; as well as The oral care composition is activated by exposing the oral care composition to water or saliva.

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