A system for ultrasound ablation therapy

Abstract

The application discloses a system for ultrasonic ablation treatment, which comprises a balloon, an ultrasonic transducer assembly, a catheter assembly and a mechanical rotating assembly; the mechanical rotating assembly comprises a shell and a motor rotating mechanism arranged in the shell; the catheter assembly comprises an outer tube and a connecting tube accommodated in the outer tube; the ultrasonic transducer assembly is arranged in the balloon; the outer tube connects the balloon and the shell; the motor rotating mechanism is connected with the ultrasonic transducer assembly through the connecting tube and can drive the ultrasonic transducer assembly to rotate; the balloon is filled with a transmission medium; the transmission medium is used for transmitting energy generated by the ultrasonic transducer assembly. The rotation of the motor rotating mechanism is controlled by a controller, the residence time of the ultrasonic transducer assembly in a target region is adjusted, thereby targeted treatment of the target region can be realized, and the transmission signal of the ultrasonic transducer assembly to the target region can be enhanced by filling the transmission medium in the balloon.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to an ultrasonic ablation treatment system. BACKGROUND

[0002] Ablation treatment, also known as destruction treatment, can destroy solid tissues such as tumors or nerve tissues. At present, common ablation treatment methods at home and abroad include laser ablation, cryoablation, microwave ablation, and radiofrequency ablation. Ablation instrument systems mainly include radiofrequency ablation instruments, cryoablation instruments, chemical ablation instruments, and ultrasonic ablation instruments.

[0003] Common radiofrequency catheter ablation instruments include SymplicityTM system, Symplicity Spyral system, EnligHTN system, etc. Among them, the SymplicityTM system is the earliest controllable radiofrequency catheter ablation instrument, which is composed of a 6F monopolar catheter, a power cable, and a radiofrequency generator, and has been used in Symplicity series clinical trials. Due to its monopolar catheter design, it can only ablate one site at a time, resulting in long operation time and long exposure to radiation time, and the SymplicityTM system has low radiofrequency energy power and limited penetration depth, making it difficult to achieve deep sympathetic nerve ablation.

[0004] Cryoablation instruments include Cryofocus cryoablation system and Freezor Xtra 7Fr cryoablation catheter system, which release refrigerant at the ablation target site, and the gasification takes away a large amount of heat to rapidly reduce the temperature of the ablation area, freeze the tissue depth, and ultimately cause local nerve tissue necrosis, achieving sympathetic nerve conduction blockage, with the characteristics of simple operation, more complete ablation, and less endothelial damage.

[0005] Chemical ablation systems mainly include Peregrine anhydrous alcohol chemical ablation system and Bullfrog system nerve toxin ablation system, which inject nerve toxin substances such as anhydrous alcohol, botulinum toxin, and vincristine into the sympathetic nerve distribution site through a microcatheter to cause nerve necrosis and block sympathetic nerves.

[0006] The ultrasonic ablation instrument mainly includes a PARADISE system and a Kona system, which emit high-frequency acoustic energy to perform annular ablation, but the annular ultrasonic ablation may cause complete denervation effect, and the sympathetic nervous response is one of important mechanisms for maintaining homeostasis of the body, so that the annular ablation may cause excessive denervation, and the stress capacity of the patient after the operation is reduced, so that the body cannot resist harmful stimuli from the outside world, and cannot maintain stable electrolyte level and blood pressure, which may significantly reduce the stress capacity of the body, and even increase the mortality of the patient when encountering blood loss, electrolyte disorder and the like. And the annular ablation may exacerbate the damage to the intima, causing serious complications such as postoperative arterial stenosis, fibrosis and thrombosis. The Kona system adopts focused ultrasound, which has a certain blindness in operation, and may also cause unnecessary damage to tissues without nerve distribution. SUMMARY

[0007] The technical problem to be solved by the technical scheme of the present application is to provide an ultrasonic ablation treatment system, which can effectively transmit energy to the target area by filling the balloon with a transmission medium and controlling the rotation speed of the ultrasonic transducer assembly driven by the motor rotation mechanism through the controller, and can adopt different rotation speeds for the target area and the non-target area, so as to realize targeted treatment of the target area.

[0008] In order to solve the above technical problems, the present application provides an ultrasonic ablation treatment system, which comprises a balloon, an ultrasonic transducer assembly, a catheter assembly and a mechanical rotation assembly.

[0009] The mechanical rotation assembly comprises a housing and a motor rotation mechanism arranged in the housing, the catheter assembly comprises an outer tube and a connecting tube accommodated in the outer tube, and the ultrasonic transducer assembly is arranged in the balloon; the outer tube is connected with the balloon and the housing, the motor rotation mechanism is connected with the ultrasonic transducer assembly through the connecting tube, and can drive the ultrasonic transducer assembly to rotate.

[0010] The balloon is filled with a transmission medium, and the transmission medium is used to transmit the energy generated by the ultrasonic transducer assembly.

[0011] In a feasible implementation manner, the ultrasonic ablation treatment system further comprises a controller, and the controller comprises a first control module and a second control module.

[0012] The ultrasonic transducer assembly comprises at least one treatment transducer and at least one imaging transducer, the treatment transducer and the imaging transducer are respectively connected with the first control module, the first control module is used for controlling the on-off and emission power of the treatment transducer and / or the imaging transducer, the imaging transducer is used for acquiring imaging information of a detection area, and the treatment transducer is used for ablating a target area in the detection area.

[0013] The second control module is connected with the motor rotating mechanism, and the second control module controls the rotating speed of the motor rotating mechanism.

[0014] In a feasible implementation, the ultrasonic ablation treatment system further comprises a liquid inlet assembly and a liquid outlet assembly, the liquid inlet assembly comprises a liquid inlet driving device and a liquid inlet pipe, the liquid inlet driving device is connected with the balloon through the liquid inlet pipe; the liquid outlet assembly comprises a liquid outlet recovery device and a liquid outlet pipe, the liquid outlet recovery device is connected with the balloon through the liquid outlet pipe.

[0015] The liquid inlet pipe, the balloon, the liquid outlet pipe and the liquid outlet recovery device constitute a liquid path, and the liquid inlet driving device is used for driving the transmission medium to flow in the liquid path.

[0016] In a feasible implementation, the liquid inlet pipe comprises a first pipe section and a third pipe section communicated with the first pipe section, the first pipe section is connected with the balloon, the first pipe section is formed by a first outer pipe cavity opened on the pipe wall of the outer pipe, and the third pipe section is connected with the liquid inlet driving device; the liquid outlet pipe comprises a second pipe section and a fourth pipe section communicated with the second pipe section, the second pipe section is connected with the balloon, the second pipe section is formed by a second outer pipe cavity opened on the pipe wall of the outer pipe, and the fourth pipe section is connected with the liquid outlet recovery device.

[0017] In a feasible implementation, the shell of the mechanical rotating assembly further comprises a catheter connecting body, a through hole is opened in the catheter connecting body, the connecting pipe passes through the through hole and is connected with the motor rotating mechanism.

[0018] The catheter connecting body is further provided with a liquid inlet through hole and a liquid outlet through hole, the liquid inlet through hole communicates the first pipe section and the third pipe section, and the liquid outlet through hole communicates the second pipe section and the fourth pipe section.

[0019] In a feasible implementation, the catheter connecting body is further provided with a positioning hole, the shell of the mechanical rotating assembly is provided with a corresponding protrusion, and the positioning hole is matched with the protrusion.

[0020] In an implementation, the connecting tube further comprises a first wire and a second wire, the first wire is connected to the therapeutic transducer, and the therapeutic transducer is connected to the controller through the first wire; the second wire is connected to the imaging transducer, and the imaging transducer is connected to the controller through the second wire.

[0021] In an implementation, the ultrasonic transducer assembly further comprises a base connected to the connecting tube, the base is provided with a first space and a second space, the first space is used for accommodating the therapeutic transducer, and the second space is used for accommodating the imaging transducer.

[0022] In an implementation, one end of the balloon is sealingly connected to the outer tube, and the other end of the balloon is provided with a guide head.

[0023] In an implementation, the guide head is made of silica gel.

[0024] In an implementation, the ultrasonic ablation therapy system is applied to the treatment of pulmonary arterial hypertension.

[0025] In another implementation, the ultrasonic ablation therapy system is applied to the treatment of renal arterial ablation therapy hypertension.

[0026] In yet another implementation, the ultrasonic ablation therapy system is applied to the treatment of asthma.

[0027] In yet another implementation, the ultrasonic ablation therapy system is applied to the treatment of heart failure.

[0028] The implementation of the present application has the following beneficial effects:

[0029] The ultrasonic ablation therapy system provided by the present application comprises a balloon, an ultrasonic transducer assembly, a catheter assembly and a mechanical rotating assembly. The mechanical rotating assembly comprises a shell and a motor rotating mechanism arranged in the shell. The catheter assembly comprises an outer tube and a connecting tube accommodated in the outer tube. The ultrasonic transducer assembly is arranged in the balloon. The outer tube connects the balloon and the shell. The motor rotating mechanism is connected to the ultrasonic transducer assembly through the connecting tube and can drive the ultrasonic transducer assembly to rotate. The balloon is filled with a transmission medium, and the transmission medium is used to transmit the energy generated by the ultrasonic transducer assembly.

[0030] The rotation of the motor rotating mechanism is controlled by the controller to adjust the residence time of the ultrasonic transducer assembly in the target area, so that targeted treatment of the target area can be realized. The transmission medium filled in the balloon can enhance the signal transmission of the ultrasonic transducer assembly to the target area. BRIEF DESCRIPTION OF DRAWINGS

[0031] Figure 1 is a structural schematic diagram of the system for ultrasound ablation therapy according to the present application;

[0032] Figure 2 is a sectional schematic diagram of the system for ultrasound ablation therapy according to the present application;

[0033] Figure 3 is a partial structural schematic diagram of the system for ultrasound ablation therapy according to the present application;

[0034] Figure 4 is a structural schematic diagram of the ultrasound transducer assembly according to the present application Figure 1 ;

[0035] Figure 5 is a structural schematic diagram of the ultrasound transducer assembly according to the present application Figure 2 ;

[0036] Figure 6 is a structural schematic diagram of the ultrasound transducer assembly according to the present application Figure 3 ;

[0037] Figure 7 is a structural schematic diagram of the system for ultrasound ablation therapy according to the present application;

[0038] Figure 8 is a partial sectional view of the system for ultrasound ablation therapy according to the present application;

[0039] Figure 9 is a structural schematic diagram of the outer tube of the catheter assembly according to the present application;

[0040] Figure 10 is a structural schematic diagram of the catheter connector according to the present application;

[0041] Figure 11 is a structural schematic diagram of the balloon according to the present application.

[0042] Reference numerals in the drawings: 100 - balloon, 110 - guide head, 200 - ultrasound transducer assembly, 210 - therapy transducer, 220 - imaging transducer, 230 - base, 2310 - first space, 2320 - second space, 300 - catheter assembly, 310 - outer tube, 320 - connecting tube, 400 - mechanical rotation assembly, 410 - housing, 420 - motor rotation mechanism, 430 - catheter connector, 4310 - positioning hole, 4320 - liquid inlet through hole, 4330 - liquid outlet through hole, 500 - liquid inlet assembly, 510 - liquid inlet driving device, 520 - liquid inlet tube, 5210 - first tube segment, 5220 - third tube segment, 600 - liquid outlet assembly, 610 - liquid outlet recovery device, 620 - liquid outlet tube, 6210 - second tube segment, 6220 - fourth tube segment. DETAILED DESCRIPTION

[0043] In order to make the above objectives, features and advantages of the present application more clear and comprehensible, specific embodiments of the present application will be described in detail below with reference to the accompanying drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present application. However, the present application can be practiced in a variety of ways beyond the specific embodiments described herein without departing from the scope of the present application, and it is understood that similar modifications of the present application will occur to the skilled in the art. Therefore, the present application is not limited to the specific embodiments disclosed below.

[0044] It should be noted that when an element is referred to as being "on" another element, it can be directly on the other element or intervening elements can also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements can also be present. The terms "vertical", "horizontal", "left", "right" and similar expressions as used herein are for the purpose of illustration only.

[0045] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used in the description of the application herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used herein, the term "and / or" includes any and all combinations of one or more of the associated listed items.

[0046] The present application provides an ultrasonic ablation treatment system, comprising a balloon, an ultrasonic transducer assembly, a catheter assembly and a mechanical rotating assembly;

[0047] The mechanical rotating assembly comprises a housing and a motor rotating mechanism arranged in the housing, and the catheter assembly comprises an outer tube and a connecting tube arranged in the outer tube, and the ultrasonic transducer assembly is arranged in the balloon; the outer tube connects the balloon and the housing, the motor rotating mechanism is connected with the ultrasonic transducer assembly through the connecting tube and can drive the ultrasonic transducer assembly to rotate;

[0048] The balloon is filled with a transmission medium, and the transmission medium is used to transmit the energy generated by the ultrasonic transducer assembly.

[0049] The balloon is wrapped outside the ultrasonic transducer assembly, the motor rotating mechanism drives the connecting tube to rotate so as to drive the ultrasonic transducer assembly connected with the connecting tube to rotate, the ultrasonic transducer assembly generates energy when working, the energy is transmitted through the transmission medium, the loss of the energy in the transmission process can be reduced, and the energy can reach the patient to achieve targeted treatment. When the ultrasonic ablation treatment system works, the outer tube of the catheter assembly, the balloon and the housing of the mechanical rotating assembly remain fixed and do not rotate with the connecting tube, there is a gap between the outer tube and the connecting tube, so that the connecting tube has enough rotating space without affecting the outer tube, and the connecting tube can be a hose.

[0050] In one possible implementation, the system for ultrasound ablation therapy further comprises a controller, the controller comprising a first control module and a second control module;

[0051] The ultrasound transducer assembly comprises at least one treatment transducer and at least one imaging transducer, the treatment transducer and the imaging transducer being respectively connected to the first control module, the first control module being configured to control the on-off and transmission power of the treatment transducer and / or the imaging transducer, the imaging transducer being configured to acquire imaging information of a detection region, and the treatment transducer being configured to ablate a target region in the detection region;

[0052] The second control module is connected to the motor rotating mechanism, and the second control module controls the rotating speed of the motor rotating mechanism.

[0053] In operation of the system for ultrasound ablation therapy, the controller can control the on-off of the imaging transducer and the treatment transducer simultaneously or in sequence, and the controller can be externally connected to the system for ultrasound ablation therapy or internally built-in the system for ultrasound ablation therapy. The first control module of the controller controls the imaging transducer to transmit pulsed ultrasound waves to the detection region and receives the imaging information fed back by the imaging transducer. The first control module also controls the treatment transducer to transmit power to the target region in the detection region. For example, in the application to the indications of pulmonary arterial hypertension and renal arterial ablation therapy for hypertension, it is necessary to ablate and destroy the sympathetic nerves and minimize the damage to non-sympathetic nerves. The detection region is all the nerve tissues observed by the imaging transducer, and the target region of the detection region is the distribution of the pulmonary arterial or renal arterial nerve tissues. The imaging transducer is subjected to an energy of 10 MHz or more. Through the transmission and reception of ultrasound energy, the distribution degree of the nerve tissues can be collected. The second control module of the controller controls the rotating speed of the motor rotating mechanism. In operation, the controller can control the rotating speed of the treatment transducer according to the imaging information fed back by the imaging transducer. In the dense distribution of the nerve tissues, the rotating speed of the treatment transducer can be controlled to be lower than 10 rad / s. Even in the most dense distribution of the nerve tissues, the rotating speed of the treatment transducer can be controlled to be 0, so as to increase the ablation and destruction of the nerve tissues. In the sparse distribution of the nerve tissues, the rotating speed of the treatment transducer can be controlled to be higher than 10 rad / s, or higher than 15 rad / s, or higher than 20 rad / s, or higher than 30 rad / s, or higher than 50 rad / s. By adopting different rotating speeds, the ablation of the nerve tissues can be realized, and the damage to non-nerves can be minimized.

[0054] In one possible implementation, the system for ultrasound ablation therapy further comprises a liquid inlet assembly and a liquid outlet assembly. The liquid inlet assembly comprises a liquid inlet driving device and a liquid inlet pipe, and the liquid inlet driving device is connected to the balloon through the liquid inlet pipe. The liquid outlet assembly comprises a liquid outlet recovery device and a liquid outlet pipe, and the liquid outlet recovery device is connected to the balloon through the liquid outlet pipe.

[0055] The liquid inlet pipe, the balloon, the liquid outlet pipe and the liquid outlet recovery device constitute a liquid path, and the liquid inlet driving device is used to drive the transmission medium to flow in the liquid path.

[0056] The liquid inlet driving device is connected with the liquid inlet pipe and used to provide the transmission medium into the balloon, and the liquid outlet recovery device is connected with the liquid outlet pipe and used to collect the transmission medium discharged from the balloon. The transmission medium enters the liquid inlet pipe and flows to the liquid outlet pipe through the balloon under the driving of the liquid inlet driving device and is recovered by the liquid outlet recovery device. The transmission medium filled in the balloon not only can transmit the energy generated by the ultrasonic transducer assembly, but also can cool the ultrasonic transducer assembly through the circulation of the transmission medium in the balloon, so that the ultrasonic transducer assembly is not damaged due to too high temperature, and meanwhile, the transmission medium can also cool the inner membrane tissue. The liquid inlet driving device can be an electric pump or a manual pump, and the transmission medium can be water. The transmission medium in the balloon can directly contact the ultrasonic transducer assembly, and the transmission medium in the balloon should be completely filled and should not exist air. The existence of air will affect the energy transmission ability of the transmission medium.

[0057] In a feasible implementation, the liquid inlet pipe includes a first pipe segment and a third pipe segment communicated with the first pipe segment, the first pipe segment is connected with the balloon, the first pipe segment is formed by a first outer pipe cavity opened on the pipe wall of the outer pipe, and the third pipe segment is connected with the liquid inlet driving device; the liquid outlet pipe includes a second pipe segment and a fourth pipe segment communicated with the second pipe segment, the second pipe segment is connected with the balloon, the second pipe segment is formed by a second outer pipe cavity opened on the pipe wall of the outer pipe, and the fourth pipe segment is connected with the liquid outlet recovery device.

[0058] The liquid inlet pipe includes a first pipe segment and a third pipe segment arranged on the outer pipe, and the liquid outlet pipe includes a second pipe segment and a fourth pipe segment arranged on the outer pipe. The first outer pipe cavity and the second outer pipe cavity are opened on the pipe wall of the outer pipe along the axial direction of the outer pipe. The first pipe segment is formed in the first outer pipe cavity, and the second pipe segment is formed in the second outer pipe cavity. The third pipe segment is connected with the liquid inlet driving device, and the third pipe segment is partially located in the shell and partially extends to outside the shell to be exposed to air. The fourth pipe segment is connected with the liquid outlet recovery device, and the fourth pipe segment is partially located in the shell and partially extends to outside the shell to be exposed to air. The first pipe segment and the third pipe segment are communicated and located between the liquid inlet driving device and the balloon. The second pipe segment and the fourth pipe segment are communicated and located between the liquid outlet recovery device and the balloon. The transmission medium flows through the third pipe segment and the first pipe segment in sequence under the driving of the liquid inlet driving device, flows to the balloon, flows through the second pipe segment and the fourth pipe segment in sequence, and finally flows to the liquid outlet recovery device.

[0059] In a feasible implementation, the shell of the mechanical rotating assembly further includes a catheter connecting body, a through hole is opened in the catheter connecting body, and the connecting pipe passes through the through hole and is connected with the motor rotating mechanism.

[0060] The conduit connector body is further provided with a liquid inlet through hole and a liquid outlet through hole, the liquid inlet through hole is communicated with the first pipe section and the third pipe section, and the liquid outlet through hole is communicated with the second pipe section and the fourth pipe section.

[0061] The conduit connector body is arranged in the shell of the mechanical rotating assembly and connected with the conduit, a through hole is formed in the conduit connector body, a connecting pipe is arranged in the through hole and connected with the motor rotating mechanism, the conduit connector body is further provided with a liquid inlet through hole and a liquid outlet through hole, one end of the outer pipe of the conduit assembly connected with the conduit connector body is provided with a liquid inlet and a liquid outlet, the liquid inlet is communicated with the first pipe section, the liquid outlet is communicated with the second pipe section, the outlet end of the third pipe section passes through the liquid inlet through hole and the liquid inlet and then enters the first pipe section, and the inlet end of the fourth pipe section passes through the liquid outlet through hole and the liquid outlet and then enters the second pipe section.

[0062] The conduit connector body comprises an outer shell and an inner pipe arranged in the shell, the liquid outlet through hole comprises a first liquid outlet through hole arranged on the outer shell and a second liquid outlet through hole arranged on the inner pipe, the liquid inlet through hole comprises a first liquid inlet through hole arranged on the outer shell and a second liquid inlet through hole arranged on the inner pipe, the outer pipe of the conduit assembly extends into the inner pipe, the center lines of the liquid inlet, the first liquid inlet through hole and the second liquid inlet through hole are coincident, and the center lines of the liquid outlet, the first liquid outlet through hole and the second liquid outlet through hole are coincident.

[0063] The outlet end of the third pipe section is provided with a first ring protrusion, the first liquid inlet through hole and the first ring protrusion are sealingly connected, the inlet end of the fourth pipe section is provided with a second ring protrusion, and the first liquid outlet through hole and the second ring protrusion are sealingly connected. The inner pipe of the conduit connector body is provided with a first glue injection hole and a second glue injection hole, the first glue injection hole surrounds the second liquid inlet through hole, the second glue injection hole surrounds the second liquid outlet through hole, the shell is provided with a third glue injection hole and a fourth glue injection hole, the third glue injection hole surrounds the first liquid inlet through hole, the center line of the third glue injection hole is coincident with that of the first liquid inlet through hole, the fourth glue injection hole surrounds the first liquid outlet through hole, and the center line of the fourth glue injection hole is coincident with that of the first liquid outlet through hole. The outlet end of the third pipe section is fixed with the outer pipe and the inner pipe of the conduit assembly by glue injected from the third glue injection hole, and the inlet end of the fourth pipe section is fixed with the outer pipe and the inner pipe of the conduit assembly by glue injected from the fourth glue injection hole.

[0064] In a feasible implementation, the conduit connector body is further provided with a positioning hole, and the shell of the mechanical rotating assembly is provided with a corresponding protrusion, the positioning hole is matched with the protrusion.

[0065] The conduit connector body is provided with at least one positioning hole, the positioning hole can be used to fix and install the conduit connector body in the shell of the mechanical rotating assembly, the shell is provided with a protrusion corresponding to the positioning hole, the protrusion and the positioning hole are matched, the conduit connector body can be clamped in the shell, and the positioning and installation of other components such as the outer pipe, the third pipe section and the fourth pipe section are facilitated.

[0066] In a feasible implementation, the connecting tube further comprises a first wire and a second wire, the first wire is connected to the therapy transducer, and the therapy transducer is connected to the controller through the first wire; the second wire is connected to the imaging transducer, and the imaging transducer is connected to the controller through the second wire.

[0067] The connecting tube further comprises a first wire connected to the therapy transducer and a second wire connected to the imaging transducer, both the first wire and the second wire are arranged in the connecting tube and are wrapped by the connecting tube, the first wire and the second wire are respectively connected to the first control module of the controller, the first control module of the controller controls the opening and closing and the emission power of the therapy transducer through the first wire, and controls the opening and closing and the emission power of the imaging transducer through the second wire.

[0068] In a feasible implementation, the ultrasonic transducer assembly further comprises a base connected to the connecting tube, the base is provided with a first space and a second space, the first space is used for accommodating the therapy transducer, and the second space is used for accommodating the imaging transducer.

[0069] The base comprises a first base and a second base connected to each other, the first base is provided with the first space, the second base is provided with the second space, and the second base further has a hollow channel in communication with the first space. The first base comprises a first end plate and first and second side plates connected to both ends of the first end plate, the first end plate is connected to the second base through the first and second side plates, the first and second side plates are arranged opposite to each other, and the second base, the first and second side plates, and the first end plate form the first space, and at least one dispensing hole is arranged on each of the first and second side plates.

[0070] The second base is in the shape of a column and comprises a first end face, a second end face, and a side face connecting the first end face and the second end face, the second end face is connected to the first and second side plates, the hollow channel penetrates through the first and second end faces, and the second space is recessed from the side face to the hollow channel. The side face is further provided with a first opening and a second opening in communication with the hollow channel, and a notch is arranged on the side face close to the second space, the notch connects the hollow channel and the second space.

[0071] The base further comprises a barrier and a connecting shaft, the barrier is arranged in the first space close to the first end plate, the barrier is connected to the first and second side plates, and the barrier is provided with an opening. The first end plate is provided with a shaft hole, the connecting shaft passes through the shaft hole and enters the opening of the barrier, and the connecting shaft is further provided with a sealing ring between the first end plate and the barrier.

[0072] The treatment transducer generates a large amount of energy during treatment, which is very easy to damage the imaging transducer, and the treatment transducer and the imaging transducer are easy to cause signal interference during work. In order to avoid the problems of damaging the imaging transducer and signal interference as much as possible, the base is introduced. By opening the first space for accommodating the treatment transducer and the second space for accommodating the imaging transducer on the base, the heat generated by the treatment transducer during treatment can be isolated, and the influence on the imaging transducer is reduced. The installation of the partition plate can also isolate the signals generated by the treatment transducer and the imaging transducer during work, and reduce the signal interference between each other. At the same time, the setting of the base ensures that the treatment transducer can rotate coaxially, and ensures the accuracy of treatment.

[0073] In a feasible implementation mode, one end of the balloon is sealingly connected with the outer tube, and the other end of the balloon is formed with a guide head. When the ultrasonic ablation treatment system enters the patient's body, the guide head can play a guiding role. The material of the guide head is relatively soft, which can reduce the discomfort caused by foreign matter entering the body. In a feasible implementation mode, the material of the guide head is silica gel.

[0074] The specific structure and working principle of the ultrasonic ablation treatment system will be described below with reference to the accompanying drawings.

[0075] As shown in Figures 1-9 An ultrasonic ablation treatment system includes a balloon 100, an ultrasonic transducer assembly 200, a catheter assembly 300 and a mechanical rotating assembly 400. The ultrasonic transducer assembly 200 is arranged in the balloon 100, the catheter assembly 300 is located between the balloon 100 and the mechanical rotating assembly 400, the catheter assembly 300 includes an outer tube 310 and a connecting tube 320 accommodated in the outer tube 310, and the mechanical rotating assembly 400 includes a shell 410 and a motor rotating mechanism 420 arranged in the shell 410. The outer tube 310 connects the balloon 100 and the shell 410, the connecting tube 320 connects the ultrasonic transducer assembly 200 and the motor rotating mechanism 420, and the ultrasonic transducer assembly 200 can rotate under the drive of the motor rotating mechanism 420. The ultrasonic transducer assembly 200 includes a treatment transducer 210, an imaging transducer 220 and a base 230. The base 230 is connected with the connecting tube 320, and the base 230 is provided with a first space 2310 and a second space 2320. The treatment transducer 210 is arranged in the first space 2310, and the imaging transducer 220 is arranged in the second space 2320.

[0076] The system for ultrasound ablation therapy further comprises a liquid inlet assembly 500 and a liquid outlet assembly 600. The liquid inlet assembly 500 comprises a liquid inlet driving device 510 and a liquid inlet pipe 520. The liquid inlet pipe 520 comprises a first pipe segment 5210 arranged on the outer pipe 310 and a third pipe segment 5220 arranged partially in the shell 410 and partially extending out of the shell 410. The first pipe segment 5210 and the third pipe segment 5220 are in communication. The liquid outlet assembly 600 comprises a liquid outlet recovery device 610 and a liquid outlet pipe 620. The liquid outlet pipe 620 comprises a second pipe segment 6210 arranged on the outer pipe 310 and a fourth pipe segment 6220 arranged partially in the shell 410 and partially extending out of the shell 410. The second pipe segment 6210 and the fourth pipe segment 6220 are in communication. The shell 410 further comprises a catheter connecting body 430 connected to the connecting pipe 310. The catheter connecting body 430 comprises a liquid inlet through hole 4320 and a liquid outlet through hole 4330. The liquid inlet through hole 4320 is connected to the first pipe segment 5210 and the third pipe segment 5220. The liquid outlet through hole 4330 is connected to the second pipe segment 6210 and the fourth pipe segment 6220. As shown in Figure 10 , the catheter connecting body 430 further comprises a positioning hole 4310 matched with a corresponding protrusion on the shell 410. The connecting pipe comprises a first wire and a second wire. The treatment transducer 210 is connected to the first wire, and the imaging transducer 220 is connected to the second wire. The controller controls the treatment transducer 210 through the first wire and controls the imaging transducer 220 through the second wire. As shown in Figure 11 , one end of the balloon 100 is sealingly connected to the outer pipe 310, and the other end of the balloon 100 forms a guide head 110.

[0077] In a feasible implementation, the system for ultrasound ablation therapy is applied to the treatment of pulmonary arterial hypertension.

[0078] The term "pulmonary arterial hypertension" refers to a hemodynamic and pathophysiological state in which the pressure in the pulmonary artery is elevated above a certain threshold, which can lead to right heart failure, and can be an independent disease, a complication, or a syndrome.

[0079] There are a large number of sympathetic nerves around the pulmonary artery. According to experimental research, patients with pulmonary arterial hypertension have excessive activation of sympathetic nerves, and the degree of sympathetic nerve activation is related to the severity of the patient's condition. The system for ultrasound ablation therapy is positioned in the pulmonary artery through femoral artery puncture. In the case that the ultrasound transducer assembly does not contact the intima of the pulmonary artery wall, the heat effect of the ultrasound transducer can be used to destroy part of the sympathetic nerves and destroy their nerve conduction function, and then the pulmonary artery pressure can also be reduced.

[0080] The system for ultrasonic ablation treatment in the application comprises a controller, a balloon, an ultrasonic transducer assembly, a catheter assembly and a mechanical rotating assembly; wherein the treatment transducer assembly is used to generate heat required for ablation treatment, in order to achieve the purpose of destroying sympathetic nerves, 8-9MHz ultrasonic energy is applied to the treatment transducer, and the temperature of the treatment transducer can reach about 50℃ within 5 seconds. In order to achieve the purpose of selectively destroying part of the nerves and reduce the processing difficulty of the annular transducer, the mechanical rotating assembly is used to drive the ultrasonic transducer assembly to rotate; by controlling the rotation speed of the ultrasonic transducer, part of the sympathetic nerves can be destroyed, and the whole annular sympathetic nerves are not destroyed in the prior art, so as to avoid causing the reduction of stress response and making the body unable to resist harmful external stimulation.

[0081] In another possible implementation, the system for ultrasonic ablation treatment is applied to treatment of renal artery ablation treatment of hypertension.

[0082] According to experimental research, the renal sympathetic nerves of a patient with hypertension are excessively activated, and blocking all or part of the renal sympathetic nerves can effectively treat hypertension.

[0083] Through the system for ultrasonic ablation treatment in the application, the balloon is sent into the left and right renal arteries through femoral artery puncture, the controller is started, and 8-9MHz ultrasonic energy is applied to the treatment transducer, so that part of the sympathetic nerves around the balloon can be ablated, and the blood pressure is reduced.

[0084] When the system for ultrasonic ablation treatment is used for ablation treatment of renal sympathetic nerves, the first control module of the controller controls the simultaneous start and stop or the sequential start and stop of the imaging transducer and the treatment transducer. In the embodiment, the controller (not shown in the figure) is connected to the system, the first control module of the controller controls the imaging transducer to emit pulsed ultrasonic waves to the nerve tissue and receives imaging information fed back by the imaging transducer, the renal sympathetic nerves and non-renal sympathetic nerves in the imaging information are artificially identified, the rotation speed of the motor rotating mechanism under different nerves is controlled, and the first control module controls the treatment transducer to emit power to the renal sympathetic nerves, so that the renal sympathetic nerves can be treated specifically, and damage to the non-renal sympathetic nerves is reduced as much as possible.

[0085] In another possible implementation, the system for ultrasonic ablation treatment is applied to treatment of asthma.

[0086] In another possible implementation, the system for ultrasonic ablation treatment is applied to treatment of heart failure.

[0087] For the present application, the system of ultrasound ablation therapy is not limited to the application in pulmonary arterial hypertension, renal arterial ablation therapy hypertension, asthma, heart failure treatment. The system of ultrasound ablation therapy in the present application can also be used for ablation of nerves, ablation of tumor tissue or ablation of other diseases of other solid tissues.

[0088] The technical features of the above-mentioned embodiments can be combined arbitrarily. In order to make the description simple, all possible combinations of the technical features in the above-mentioned embodiments are not described, however, as long as the combinations of the technical features do not exist contradictory, it should be considered that it is within the scope of the present disclosure.

[0089] The above-mentioned embodiments only express several embodiments of the present application, the description is more specific and detailed, but it should not be understood as a limitation to the scope of the patent. It should be pointed out that for ordinary skilled in the art, without departing from the concept of the present application, a number of variations and improvements can be made, which are within the scope of the present application. Therefore, the scope of protection of the present application patent should be subject to the appended claims.

Claims

1. A system for ultrasound ablation therapy, characterized by, The system comprises a balloon, an ultrasonic transducer assembly, a catheter assembly and a mechanical rotating assembly; The mechanical rotating assembly comprises a housing and a motor rotating mechanism arranged in the housing, the catheter assembly comprises an outer tube and a connecting tube accommodated in the outer tube, and the ultrasonic transducer assembly is arranged in the balloon; the outer tube connects the balloon and the housing, the motor rotating mechanism is connected with the ultrasonic transducer assembly through the connecting tube and can drive the ultrasonic transducer assembly to rotate; The balloon is filled with a transmission medium, and the transmission medium is used for transmitting energy generated by the ultrasonic transducer assembly; The system for ultrasonic ablation treatment further comprises a controller, the controller comprises a first control module and a second control module, the ultrasonic transducer assembly comprises at least one treatment transducer and at least one imaging transducer, the first control module is used for controlling the on-off and emission power of the treatment transducer and / or the imaging transducer, the second control module controls the rotating speed of the motor rotating mechanism and adopts different rotating speeds for target regions and non-target regions; wherein the controller controls the rotating speed of the treatment transducer according to the imaging information fed back by the imaging transducer.

2. The system for ultrasound ablation therapy according to claim 1, wherein, The treatment transducer and the imaging transducer are respectively connected with the first control module in signal, the imaging transducer is used for acquiring imaging information of a detection region, and the treatment transducer is used for ablating a target region in the detection region. The second control module is connected with the motor rotating mechanism in signal.

3. The system for ultrasound ablation therapy of claim 1, wherein, The system for ultrasonic ablation treatment further comprises a liquid inlet assembly and a liquid outlet assembly, the liquid inlet assembly comprises a liquid inlet driving device and a liquid inlet pipe, and the liquid inlet driving device is connected with the balloon through the liquid inlet pipe; the liquid outlet assembly comprises a liquid outlet recovery device and a liquid outlet pipe, and the liquid outlet recovery device is connected with the balloon through the liquid outlet pipe; The liquid inlet pipe, the balloon, the liquid outlet pipe and the liquid outlet recovery device form a liquid path, and the liquid inlet driving device is used for driving the transmission medium to flow in the liquid path.

4. The system for ultrasound ablation therapy according to claim 3, wherein The liquid inlet pipe comprises a first pipe section and a third pipe section communicated with the first pipe section, the first pipe section is connected with the balloon, the first pipe section is formed by a first outer tube cavity opened in the pipe wall of the outer tube, and the third pipe section is connected with the liquid inlet driving device; the liquid outlet pipe comprises a second pipe section and a fourth pipe section communicated with the second pipe section, the second pipe section is connected with the balloon, the second pipe section is formed by a second outer tube cavity opened in the pipe wall of the outer tube, and the fourth pipe section is connected with the liquid outlet recovery device.

5. The system for ultrasound ablation therapy according to claim 4, wherein The housing of the mechanical rotating assembly further comprises a catheter connecting body, a through hole is opened in the catheter connecting body, the connecting tube passes through the through hole and is connected with the motor rotating mechanism; The catheter connecting body is further provided with a liquid inlet through hole and a liquid outlet through hole, the liquid inlet through hole communicates the first pipe section and the third pipe section, and the liquid outlet through hole communicates the second pipe section and the fourth pipe section.

6. The system for ultrasound ablation therapy according to claim 5, wherein The catheter connecting body is further provided with a positioning hole, and the housing of the mechanical rotating assembly is provided with a corresponding protrusion, the positioning hole is matched with the protrusion.

7. The system for ultrasound ablation therapy of claim 1, wherein, The connecting pipe further comprises a first wire and a second wire, the first wire is connected with the treatment transducer, and the treatment transducer is connected with the controller through the first wire; the second wire is connected with the imaging transducer, and the imaging transducer is connected with the controller through the second wire.

8. The system for ultrasound ablation therapy of claim 2, wherein, The ultrasonic transducer assembly further comprises a base connected with the connecting pipe, the base is provided with a first space and a second space, the first space is used for accommodating the treatment transducer, and the second space is used for accommodating the imaging transducer.

9. The system for ultrasound ablation therapy of claim 1, wherein, One end of the balloon is sealingly connected with the outer pipe, and the other end of the balloon is formed with a guide head.

10. The system for ultrasound ablation therapy according to claim 9, wherein, The material of the guide head is silica gel.

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