A fixing device for CT detection of mice in lung cancer immunity experiments

Abstract

The present invention discloses a fixing device for CT detection of mice for lung cancer immunity experiment, comprising a lying plate, a lying groove on the lying plate, a pair of movable structures slidably connected at the left and right edges of the top surface of the lying plate, the movable structure comprising a movable block, a sliding rod and a dial plate, a clamping structure rotatably connected on the movable block, and the clamping structure comprising a rotating seat and a clamping plate. The present invention provides the movable structure and the clamping structure, so that when the mouse is subjected to CT detection, the limbs of the mouse can be clamped and fixed by the clamping structure, so as to achieve the purpose of fixing the limbs of the mouse, so that the body position of the mouse is fixed, and the situation that the body position of the mouse is changed due to the activity of the mouse during the detection process is prevented.

Description

Technical Field

[0001] The invention belongs to the technical field of animal in vivo imaging, and in particular relates to a fixing device for CT detection of mice used in lung cancer immunity experiments. Background Art

[0002] Lung cancer is a malignant tumor originating from the bronchial mucosa or glands of the lungs. The incidence and mortality rates of lung cancer are growing fastest, and it is one of the malignant tumors that poses the greatest threat to human health and life. The treatment for lung cancer mainly uses systemic intravenous chemotherapy and targeted therapy, but recently an immunotherapy has emerged. Immunotherapy mainly uses infusion to give patients immunotherapy drugs, which is mainly used for non-small cell lung cancer.

[0003] Laboratory mice are essential experimental organisms in the development of immunotherapy. They are easy to reproduce, have a large number of each generation, have a limited lifespan, and have clear genetic information. They are excellent animals for biological experiments. Lung cancer immunity experiments on mice play an important role in the research on the treatment of lung cancer. In lung cancer immunity experiments on experimental mice, the mice undergoing the immunity experiments need to be subjected to CT examination in an imaging device to observe the lungs of the mice. When CT examination of mice is performed in the imaging device, the mice may sometimes suddenly move during the examination, causing the body position of the mouse to change, resulting in a change in the position of the CT examination, and causing the imaging position of the mouse to shift during the CT examination, making it difficult for the inspector to directly compare the images of the examination.

[0004] The information disclosed in this background technology section is only intended to enhance the understanding of the overall background of the invention and should not be regarded as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to a person skilled in the art. Summary of the invention

[0005] The purpose of the present invention is to provide a fixing device for CT detection of lung cancer immunity experimental mice to solve the above-mentioned problems of the prior art.

[0006] To achieve the above-mentioned purpose, the present invention provides a fixing device for CT detection of mice for lung cancer immunity experiment, including a lying board, a lying groove is provided at the top of the lying board, and movable grooves are provided at the left and right edges of the top surface of the lying board, and a pair of movable structures are slidably connected in each of the movable grooves, and the movable structures include a movable block sleeved on the inner side of the movable groove, a sliding rod fixed on the outer end surface of the movable block, and a paddle slidably connected to the sliding rod, and a clamping structure is rotatably connected to the movable block, and the clamping structure includes a rotating seat installed on the movable block and a clamping plate arranged above the rotating seat.

[0007] In the technical solution of the present invention, side grooves are provided on the inner walls on both sides of the movable groove, and the side grooves near the outer edge of the lying board are connected with the side end surfaces of the lying board. The left and right ends of the movable block are provided with convex plates, and the two convex plates respectively extend into the two side grooves and are slidably connected with the lying board.

[0008] In the technical solution of the present invention, the head end of the sliding rod passes through the side groove and is fixedly connected to the movable block, the end of the sliding rod is provided with a baffle plate, the outer side of the sliding rod is sleeved with a first abutment spring, the shift plate is sleeved on the outer side of the sliding rod, and the first abutment spring is clamped between the baffle plate and the shift plate and is in a pre-stressed state.

[0009] In the technical solution of the present invention, a plurality of tooth grooves are provided on the left and right edges of the top and bottom surfaces of the lying board, a convex column is provided on the shift plate at the end position close to the end surface of the lying board, and convex teeth are provided on the top and bottom edges of the ends of the convex column, and the convex teeth can extend into the tooth grooves.

[0010] In the technical solution of the present invention, a sleeve hole is provided at the top of the movable block, the rotating seat is in a cylindrical structure and is sleeved in the sleeve hole, an annular groove is provided on the outer surface of the rotating seat, and pins are inserted at both ends of the movable block, and the pins extend into the annular groove.

[0011] In the technical solution of the present invention, a pair of protrusions are provided at the top of the rotating seat, and grooves are provided at the tops of the protrusions, and the limbs of the mouse can overlap on the grooves.

[0012] In the technical solution of the present invention, the card plate is located between two protrusions, the middle part of the card plate is an arc-shaped plate structure protruding upward, sliding columns are fixed at both ends of the card plate, a pair of sliding holes are opened at the top of the rotating seat, the sliding columns pass through the sliding holes, and a bottom plate is fixed at the bottom ends of the two sliding columns. A second abutment spring is arranged between the bottom plate and the bottom end of the rotating seat, and the second abutment spring is sleeved on the outer side of the sliding column.

[0013] In the technical solution of the present invention, a lifting rod is fixed to the top end of the clamping plate.

[0014] In the technical solution of the present invention, the lying plate is installed on the detection equipment, a fixed platform is installed on the front end surface of the detection equipment, the top of the fixed platform is slidably connected with a movable seat, and a fixed plate is provided at the end of the lying plate, and the fixed plate is fixed on the front end surface of the movable seat.

[0015] In summary, due to the adoption of the above technical solution, the beneficial effects of the present invention are:

[0016] 1. In the present invention, a movable structure is arranged on the lying board and a clamping structure is arranged on the movable structure, so that when the mouse is subjected to CT detection, the limbs of the mouse lying on the lying board can pass through the clamping structure, so that the limbs of the mouse can be clamped and fixed by the clamping structure, thereby achieving the purpose of fixing the limbs of the mouse, fixing the body position of the mouse, and preventing the mouse from changing its body position due to activity during the detection process.

[0017] 2. In the present invention, the movable structure is enabled to move along the movable groove on the lying board, so that the position of the movable structure on the lying board can be conveniently adjusted according to the body shape of the mouse. At the same time, the clamping structure is enabled to rotate on the movable structure, so that after the position of the movable structure is adjusted, the protrusion and the clamping plate for clamping the mouse's limbs can be used to clamp the mouse's limbs in the direction of the mouse's limbs by rotating the clamping plate on the movable block, thereby preventing the mouse's limbs from being damaged. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0019] Figure 2 It is a schematic diagram of the use in the present invention;

[0020] Figure 3 It is a structural diagram of the lying board in the present invention;

[0021] Figure 4 An exploded view of the active structure of the present invention;

[0022] Figure 5 It is a structural diagram of the active block in the present invention;

[0023] Figure 6 It is a structural diagram of the paddle in the present invention;

[0024] Figure 7 An exploded view of the clamping structure of the present invention;

[0025] Figure 8 is a cross-sectional view of the rotating seat in the present invention;

[0026] Fig. 9 It is a structural diagram of the card board in the present invention.

[0027] Description of reference numerals:

[0028] 1-lying plate; 11-lying groove; 12-movable groove; 13-side groove; 14-tooth groove; 15-fixed plate; 2-movable structure; 21-movable block; 211-convex plate; 212-sleeve hole; 213-pin column; 22-sliding rod; 221-baffle; 222-first abutting spring; 23-push plate; 231-convex column; 232-convex tooth; 3-clamping structure; 31-rotating seat; 311-convex block; 312-groove; 313-ring groove; 314-sliding hole; 32-clamping plate; 321-sliding column; 322-bottom plate; 323-lifting rod; 33-second abutting spring; 4-detection equipment; 41-fixed platform; 42-movable seat. DETAILED DESCRIPTION

[0029] The specific implementation modes of the present invention are described in detail below in conjunction with the accompanying drawings, but it should be understood that the protection scope of the present invention is not limited by the specific implementation modes.

[0030] Unless explicitly stated otherwise, throughout the specification and claims, the term “comprise” or variations such as “include” or “comprising”, etc., will be understood to include the stated elements or components but not to exclude other elements or components.

[0031] Reference Figure 1-Figure 9 The fixing device for CT detection of mice for lung cancer immunity experiment of the present invention comprises a lying board 1, a lying groove 11 is provided at the top of the lying board 1, the lying board 1 is installed on the detection equipment 4, a fixed platform 41 is installed on the front end surface of the detection equipment 4, a movable seat 42 is slidably connected to the top of the fixed platform 41, a fixing plate 15 is provided at the end of the lying board 1, and the fixing plate 15 is fixed on the front end surface of the movable seat 42. By placing the mouse in the lying groove 11, the mouse can lie on the lying board 1, and at this time, the movable seat 42 is controlled to drive the lying board 1 to enter the detection equipment 4 so as to perform CT detection on the mouse.

[0032] In the present invention, movable grooves 12 are provided at the left and right edges of the top surface of the lying board 1, and a pair of movable structures 2 are slidably connected in each movable groove 12, and the movable structure 2 includes a movable block 21 sleeved on the inner side of the movable groove 12, a sliding rod 22 fixed on the outer end surface of the movable block 21, and a dial plate 23 slidably connected to the sliding rod 22. Side grooves 13 are provided at the inner walls of the left and right sides of the movable groove 12, and the side grooves 13 near the outer end edge of the lying board 1 are connected to the side end surface of the lying board 1. The left and right ends of the movable block 21 are provided with convex plates 211, and the two convex plates 211 extend into the two side grooves 13 respectively, so that the movable block 21 can be restricted in the movable groove 12 under the action of the convex plates 211, and the movable block 21 can be slidably connected with the lying board 1, so that the movable block 21 can move along the movable groove 12 on the lying board 1, so as to achieve the purpose of adjusting the position of the movable block 21 on the lying board 1.

[0033] Specifically, the head end of the sliding rod 22 passes through the side groove 13 and is fixedly connected to the movable block 21, the end of the sliding rod 22 is provided with a baffle 221, the outer side of the sliding rod 22 is sleeved with a first abutment spring 222, the shift plate 23 is sleeved on the outer side of the sliding rod 22, the first abutment spring 222 is clamped between the baffle 221 and the shift plate 23 and is in a pre-stressed state, under the elastic force of the first abutment spring 222, the shift plate 23 can always abut against the side end surface of the lying board 1.

[0034] Furthermore, a plurality of tooth grooves 14 are provided at the left and right edges of the top and bottom surfaces of the lying plate 1, a convex column 231 is provided at the end surface position close to the lying plate 1 on the dial plate 23, and convex teeth 232 are provided at the top and bottom edges of the ends of the convex columns 231. When the dial plate 23 is leaned against the lying plate 1 under the action of the first abutment spring 222, the convex teeth 232 can extend into the tooth grooves 14, so that the position of the movable structure 2 can be fixed at the tooth grooves 14 by the convex teeth 232 at this time, thereby achieving the purpose of positioning the movable structure 2 on the lying plate 1 and preventing the movable structure 2 from accidentally sliding. When it is necessary to adjust the position of the movable structure 2, the inspection personnel can push the dial plate 23 outward so that the dial plate 23 drives the convex teeth 232 away from the tooth grooves 14, and the movable block 21 can move normally along the movable groove 12 to achieve the purpose of adjusting the position of the movable structure 2.

[0035] In the above scheme, the movable block 21 is rotatably connected with the clamping structure 3, and the clamping structure 3 includes a rotating seat 31 installed on the movable block 21 and a clamping plate 32 arranged above the rotating seat 31. A sleeve hole 212 is provided at the top of the movable block 21, and the rotating seat 31 is a cylindrical structure and sleeved in the sleeve hole 212. An annular groove 313 is provided on the outer surface of the rotating seat 31. Pins 213 are inserted at both the left and right ends of the movable block 21, and the pins 213 extend into the annular groove 313, so that the rotating seat 31 is sleeved in the sleeve hole 212 and can be restricted in the sleeve hole 212 by the pins 213, so that the rotating seat 31 can rotate in the sleeve hole 212 while preventing the rotating seat 31 from escaping from the sleeve hole 212.

[0036] Specifically, a pair of protrusions 311 are provided at the top of the rotating seat 31, and a groove 312 is provided at the top of the protrusion 311, and the limbs of the mouse can be overlapped on the groove 312. The card plate 32 is located between the two protrusions 311, and the middle part of the card plate 32 is an arc-shaped plate-like structure that protrudes upward. Sliding columns 321 are fixed at both ends of the card plate 32, and a pair of sliding holes 314 are provided at the top of the rotating seat 31. The sliding columns 321 pass through the sliding holes 314, so that the card plate 32 is slidably connected with the rotating seat 31 through the sliding columns 321, so that the card plate 32 can move up and down above the rotating seat 31. When the card plate 32 moves upward, the limbs of the mouse can be overlapped on the protrusions 311 and the card plate 32. At this time, the card plate 32 can be released to press the card plate 32 on the upper part of the mouse limbs, so that the mouse limbs are clamped between the protrusions 311 and the card plate 32. A bottom plate 322 is fixed to the bottom end of the two sliding columns 321, and a second abutment spring 33 is arranged between the bottom plate 322 and the bottom end of the rotating seat 31. The second abutment spring 33 is sleeved on the outer side of the sliding column 321. Under the elastic force of the second abutment spring 33, the bottom plate 322 always drives the clamping plate 32 to move downward through the sliding column 321. When the mouse's limbs are clamped between the protrusion 311 and the clamping plate 32, the clamping plate 32 can always clamp the mouse's limbs under the action of the second abutment spring 33, preventing the mouse's limbs from falling off the clamping structure 3, thereby achieving the purpose of fixing the mouse's position.

[0037] Furthermore, a lifting rod 323 is fixed to the top of the clamping plate 32, so that the inspector can easily drive the clamping plate 32 to move by operating the lifting rod 323, so as to clamp and fix the limbs of the mouse or release the limbs of the mouse.

[0038] The working principle of the fixing device for CT detection of lung cancer immunity experimental mice of the present invention is specifically as follows:

[0039] First, place the mouse to be tested in the lying groove 11 on the top surface of the lying board 1 and spread the mouse's limbs outward, then push the paddle 23 outward so that the paddle 23 drives the convex teeth 232 away from the tooth groove 14, then push the movable structure 2 so that the movable structure 2 moves along the movable groove 12 to the position of the mouse's limbs, then release the paddle 23, so that the movable structure 2 can correspond to the position of the mouse's limbs, finally pull the lifting rod 323 upward so that the lifting rod 323 drives the card plate 32 to move upward, and then rotate the lifting rod 323 so that the groove 31 2 is in the same direction as the direction of the mouse limbs, and the mouse limbs are placed on the groove 312. Then, the lifting rod 323 is loosened, so that the bottom plate 322 can drive the clamping plate 32 to be clamped on the top of the mouse limbs through the sliding column 321 under the elastic force of the first abutting spring 222, so that the mouse limbs are clamped between the protrusion 311 and the clamping plate 32, preventing the mouse limbs from falling off from the clamping structure 3, thereby achieving the purpose of fixing the mouse position and preventing the mouse from changing its body position due to activity during the detection process.

[0040] The foregoing description of specific exemplary embodiments of the present invention is for the purpose of illustration and demonstration. These descriptions are not intended to limit the present invention to the precise form disclosed, and it is clear that many changes and variations can be made based on the above teachings. The purpose of selecting and describing the exemplary embodiments is to explain the specific principles of the present invention and its practical application, so that those skilled in the art can realize and utilize various different exemplary embodiments of the present invention and various different selections and changes. The scope of the present invention is intended to be limited by the claims and their equivalents.

Claims

1. A fixing device for CT detection of mice in lung cancer immunity experiments, comprising a lying board (1), Features: The top of the lying board (1) is provided with a lying groove (11), and the left and right edges of the top surface of the lying board (1) are provided with movable grooves (12), and each movable groove (12) is slidably connected with a pair of movable structures (2), and the movable structure (2) comprises a movable block (21) sleeved on the inner side of the movable groove (12), a sliding rod (22) fixed on the outer end surface of the movable block (21), and a shifting plate (23) slidably connected with the sliding rod (22). The movable block (21) is rotatably connected with a clamping structure (3), and the clamping structure (3) comprises a rotating seat (31) mounted on the movable block (21) and a clamping plate (32) arranged above the rotating seat (31); side grooves (13) are provided on the inner walls on both sides of the movable groove (12), and the side grooves (13) near the outer edge of the lying plate (1) are connected to the side end surface of the lying plate (1); the movable block (21) is provided at both ends. The two convex plates (211) are respectively extended into the two side grooves (13) and are slidably connected to the lying plate (1); the head end of the sliding rod (22) passes through the side groove (13) and is fixedly connected to the movable block (21); the end of the sliding rod (22) is provided with a baffle (221); the outer side of the sliding rod (22) is provided with a first abutment spring (222); the dial plate (23) is sleeved on the outer side of the sliding rod (22); the first The abutment spring (222) is sandwiched between the baffle plate (221) and the shift plate (23) and is in a pre-stressed state; a plurality of tooth grooves (14) are provided at the left and right edges of the top and bottom surfaces of the lying plate (1); a convex column (231) is provided on the shift plate (23) at an end surface position close to the lying plate (1); and convex teeth (232) are provided at the top and bottom edges of the ends of the convex columns (231); the convex teeth (232) can extend into the tooth grooves (14); The top of the movable block (21) is provided with a sleeve hole (212); the rotating seat (31) is in a cylindrical structure and sleeved in the sleeve hole (212); an annular groove (313) is provided on the outer surface of the rotating seat (31); both left and right ends of the movable block (21) are plugged with pins (213), and the pins (213) extend into the annular groove (313); a pair of protrusions (311) are provided at the top of the rotating seat (31); a groove (312) is provided at the top of the protrusion (311), and the limbs of the mouse can overlap the groove (312); the clamping plate (32) is located at Between the two protrusions (311), the middle part of the card plate (32) is an arc-shaped plate-like structure protruding upward, and sliding columns (321) are fixed at both ends of the card plate (32). A pair of sliding holes (314) are opened at the top of the rotating seat (31), and the sliding columns (321) pass through the sliding holes (314). A bottom plate (322) is fixed at the bottom ends of the two sliding columns (321), and a second abutment spring (33) is arranged between the bottom plate (322) and the bottom end of the rotating seat (31), and the second abutment spring (33) is sleeved on the outer side of the sliding column (321).

2. The fixing device for CT detection of lung cancer immunity experimental mice according to claim 1, Features: A lifting rod (323) is fixed to the top end of the clamping plate (32).

3. The fixing device for CT detection of lung cancer immunity experimental mice according to claim 1, Features: The lying plate (1) is installed on the detection device (4), a fixed platform (41) is installed on the front end surface of the detection device (4), the top end of the fixed platform (41) is slidably connected to a movable seat (42), and a fixed plate (15) is provided at the end of the lying plate (1), and the fixed plate (15) is fixed on the front end surface of the movable seat (42).

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