A cryoablation temperature control method, device and cryosurgical system

Abstract

The present invention discloses a cryoablation temperature control method, device and cryosurgery system. The method comprises: obtaining the real-time temperature value and the preset target temperature value of the ablation needle; adjusting the opening of the cold working fluid output proportional valve and the hot working fluid output proportional valve according to the difference between the real-time temperature value and the target temperature value, so that the real-time temperature value reaches the target temperature value; maintaining the opening of the cold working fluid output proportional valve and the hot working fluid output proportional valve unchanged. By applying the method of the present invention, it is possible to fine-tune the temperature output by the ablation needle during cryosurgery when performing low temperature or rewarming operations, thereby improving the treatment effect.

Description

[0001] This application is a divisional application with application number CN202111310287.4 and invention name “A cryoablation temperature control method, device and cryosurgery system”. Technical Field

[0002] The present invention belongs to the technical field of cryoablation, and in particular relates to a cryoablation temperature control method, device and cryosurgery system. Background Art

[0003] After years of development, more and more tissue ablation technologies are used clinically. Among them, cryoablation is a representative technology that uses cryogenic devices to control the cooling, freezing, and rewarming of the lesion tissue, thereby causing irreversible damage or even necrosis of cells.

[0004] Cryoablation has been widely used in tumor treatment, using freezing to kill tumor cells and achieve the purpose of ablating the treated tissue. The killing mechanism of cryoablation on cells is: cell dehydration and shrinkage; mechanical damage caused by ice crystals in cells; toxic concentration of cell electrolytes and changes in pH; blood congestion and microthrombosis; and immune effects. Cryoablation not only has less surgical trauma, but also has the advantages of precise positioning, hemostasis and analgesia, fewer postoperative complications, and high safety.

[0005] Existing cryosurgery systems use cold / hot fluids to cool or rewarm the ablation needle. During the low-temperature cooling or rewarming process, the temperature is often unable to be adjusted to a certain temperature range. Summary of the invention

[0006] The technical problem to be solved by the present invention is how to fine-tune the temperature output by the ablation needle during hypothermia or rewarming and reduce the waste of cold medium during hypothermia. In response to at least one of the above technical problems, the present invention provides a cryoablation temperature control method, device and cryosurgery system.

[0007] In a first aspect, the present invention provides a cryoablation temperature control method, the method comprising:

[0008] Obtaining the real-time temperature value and preset target temperature value of the ablation needle;

[0009] According to the difference between the real-time temperature value and the target temperature value, adjusting the opening of the cold working medium output proportional valve and the hot working medium output proportional valve so that the real-time temperature value reaches the target temperature value;

[0010] The openings of the cold working medium output proportional valve and the hot working medium output proportional valve are maintained unchanged.

[0011] According to an embodiment of the present invention, preferably, before obtaining the real-time temperature value and the preset target temperature value of the ablation needle, the method includes:

[0012] Determine that the current state is a low temperature operation state.

[0013] According to an embodiment of the present invention, preferably, adjusting the opening of the cold working medium output proportional valve and the hot working medium output proportional valve according to the difference between the real-time temperature value and the target temperature value so that the real-time temperature value reaches the target temperature value includes:

[0014] Controlling and adjusting the cold working fluid output proportional valve and the hot working fluid output proportional valve so that the opening of the hot working fluid output proportional valve is reduced to 0% and the opening of the cold working fluid output proportional valve is increased to 100%;

[0015] Determining whether the real-time temperature value is equal to the target temperature value;

[0016] If the real-time temperature value is not equal to the target temperature value, the opening of the thermal medium output proportional valve is adjusted to make the real-time temperature value reach the target temperature value.

[0017] According to an embodiment of the present invention, preferably, before obtaining the real-time temperature value and the preset target temperature value of the ablation needle, the method includes:

[0018] Determine that the current state is the rewarming operation state.

[0019] According to an embodiment of the present invention, preferably, adjusting the opening of the cold working medium output proportional valve and the hot working medium output proportional valve according to the difference between the real-time temperature value and the target temperature value so that the real-time temperature value reaches the target temperature value includes:

[0020] Controlling and adjusting the cold working fluid output proportional valve and the hot working fluid output proportional valve so that the opening of the hot working fluid output proportional valve increases to 100% and the opening of the cold working fluid output proportional valve decreases to 0%;

[0021] Determining whether the real-time temperature value is equal to the target temperature value;

[0022] If it is not the target temperature value, the opening of the cold working medium output proportional valve is adjusted to make the real-time temperature value reach the target temperature value.

[0023] According to an embodiment of the present invention, preferably, before obtaining the real-time temperature value and the preset target temperature value of the ablation needle, the method includes:

[0024] Start the cryosurgery system;

[0025] Determine whether to perform low temperature operation;

[0026] If low temperature operation is performed, check whether there is any abnormality in the feedback temperature measurement circuit of the phase separation valve;

[0027] When there is no abnormality in the feedback temperature measurement loop of the phase separation valve, closing or opening the phase separation valve according to the feedback temperature;

[0028] When there is an abnormality in the feedback temperature measurement loop of the phase separation valve, the phase separation valve is opened.

[0029] According to an embodiment of the present invention, preferably, when there is no abnormality in the feedback temperature measurement loop of the phase separation valve, closing or opening the phase separation valve according to the feedback temperature includes:

[0030] When the feedback temperature is greater than -120°C, the phase separation valve is opened;

[0031] When the feedback temperature is less than or equal to -120° C. and the temperature of the ablation needle is less than or equal to -150° C., closing the phase separation valve;

[0032] When the temperature of the ablation needle is greater than -150°C, the state of the phase separation valve is maintained unchanged.

[0033] According to an embodiment of the present invention, preferably, after starting the cryosurgery system, the method further includes:

[0034] Open the booster valve of the cold tank for containing the cold working medium to increase the pressure in the cold tank;

[0035] Determine whether the pressure value in the cold tank is within a first preset pressure value range;

[0036] When the pressure value in the cold tank is within the first preset pressure value range, the boost valve is closed; otherwise, the boost valve is opened.

[0037] According to an embodiment of the present invention, preferably, after starting the cryosurgery system, the method further includes:

[0038] Open the booster valve of the cold tank for containing the cold working medium to increase the pressure in the cold tank;

[0039] Determine whether the pressure value in the cold tank is within a second preset pressure value range;

[0040] When the pressure value in the cold tank is greater than the maximum value of the second preset pressure value range, opening the regulating valve and the air release valve of the cold tank;

[0041] When the pressure value in the cold tank is within the second preset pressure value range, the regulating valve is opened and the air release valve is closed at the same time;

[0042] When the pressure value in the cold tank is less than the minimum value of the second preset pressure value range, the regulating valve and the air release valve are closed.

[0043] In a second aspect, the present invention provides a cryoablation temperature control device, the device comprising:

[0044] A temperature acquisition module is used to obtain the real-time temperature value of the ablation needle and the preset target temperature value;

[0045] A regulating module, used for regulating the opening of the cold working medium output proportional valve and the hot working medium output proportional valve according to the difference between the real-time temperature value and the target temperature value, so that the real-time temperature value reaches the target temperature value;

[0046] The maintaining module is used to maintain the opening of the cold working medium output proportional valve and the hot working medium output proportional valve unchanged.

[0047] According to an embodiment of the present invention, preferably, the device includes:

[0048] The low temperature operation determination module is used to determine that the current state is a low temperature operation state before obtaining the real-time temperature value and the preset target temperature value of the ablation needle.

[0049] According to an embodiment of the present invention, preferably, the adjustment module includes:

[0050] The first control submodule is used to control and adjust the cold working medium output proportional valve and the hot working medium output proportional valve, so that the opening of the hot working medium output proportional valve is reduced to 0% and the opening of the cold working medium output proportional valve is increased to 100%;

[0051] A first judging module, used for judging whether the real-time temperature value is equal to the target temperature value;

[0052] The first regulating module is used for regulating the opening of the thermal medium output proportional valve when the real-time temperature value is not the target temperature value, so that the real-time temperature reaches the target temperature.

[0053] According to an embodiment of the present invention, preferably, the device includes:

[0054] The high temperature operation determination module is used to determine that the current state is a rewarming operation state before obtaining the real-time temperature value and the preset target temperature value of the ablation needle.

[0055] According to an embodiment of the present invention, preferably, the adjustment module further includes:

[0056] The second control submodule controls and adjusts the cold working fluid output proportional valve and the hot working fluid output proportional valve, so that the opening of the hot working fluid output proportional valve increases to 100% and the opening of the cold working fluid output proportional valve decreases to 0%;

[0057] A second judgment module is used to judge whether the real-time temperature is the target temperature;

[0058] The second regulating module is used for regulating the opening of the cold medium output proportional valve if the temperature is not the target temperature, so that the real-time temperature reaches the target temperature.

[0059] According to an embodiment of the present invention, preferably, the device further includes:

[0060] A start module, used for starting the cryosurgery system;

[0061] A state judgment module is used to determine whether to perform low temperature operation;

[0062] A detection module, used to detect whether there is an abnormality in the feedback temperature measurement circuit of the phase separation valve when performing low-temperature operation;

[0063] The phase separation valve regulating module is used to close or open the phase separation valve according to the feedback temperature when there is no abnormality in the feedback temperature measurement circuit of the phase separation valve; and to open the phase separation valve when there is an abnormality in the feedback temperature measurement circuit of the phase separation valve.

[0064] According to an embodiment of the present invention, preferably, the regulating phase separation valve module is specifically used for:

[0065] When the feedback temperature is greater than -120°C, the phase separation valve is opened;

[0066] When the feedback temperature is less than or equal to -120° C. and the temperature of the ablation needle is less than or equal to -150° C., closing the phase separation valve;

[0067] When the temperature of the ablation needle is greater than -150°C, the state of the phase separation valve is maintained unchanged.

[0068] According to an embodiment of the present invention, preferably, the device further includes:

[0069] The first cold tank pressure regulating module is used to open the boosting valve of the cold tank for containing the cold working medium to increase the pressure in the cold tank; and to determine whether the pressure value in the cold tank is within the first preset pressure value range; and when the pressure value in the cold tank is within the first preset pressure value range, close the boosting valve, otherwise open the boosting valve.

[0070] According to an embodiment of the present invention, preferably, the device further includes:

[0071] The second cold tank pressure regulating module is used to open the boost valve of the cold tank for containing the cold working medium to increase the pressure in the cold tank; and to determine whether the pressure value in the cold tank is within a second preset pressure value range; and when the pressure value in the cold tank is greater than the maximum value of the second preset pressure value range, open the regulating valve and the air release valve of the cold tank; and when the pressure value in the cold tank is within the second preset pressure value range, open the regulating valve and close the air release valve at the same time; and when the pressure value in the cold tank is less than the minimum value of the second preset pressure value range, close the regulating valve and the air release valve.

[0072] In a third aspect, the system comprises the apparatus as described above, and is used to implement the method as described above.

[0073] According to an embodiment of the present invention, preferably, the system further comprises a processor, wherein the processor comprises a micro control unit and a field programmable gate array.

[0074] In a fourth aspect, the present invention provides a storage medium having a computer program stored thereon, characterized in that the computer program implements the steps of the above method when executed by a processor.

[0075] Compared with the prior art, one or more embodiments of the above scheme may have the following advantages or beneficial effects: first, the real-time temperature value and the preset target temperature value of the ablation needle are obtained; if the real-time temperature value does not reach the target temperature value, the opening of the cold working fluid output proportional valve and the hot working fluid output proportional valve are adjusted according to the difference between the real-time temperature value and the target temperature value, so that the real-time temperature value reaches the target temperature value, and then the opening of the cold working fluid output proportional valve and the hot working fluid output proportional valve is maintained unchanged. By applying the method of the present invention, the temperature output by the ablation needle can be adjusted according to actual use requirements when performing low temperature or rewarming operations during cryosurgery, thereby improving the treatment effect.

[0076] Other features and advantages of the present invention will be described in the following description, and partly become apparent from the description, or understood by practicing the present invention. The purpose and other advantages of the present invention can be realized and obtained by the structures particularly pointed out in the description, claims and drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0077] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0078] Figure 1 A flow chart of a cryoablation temperature control method according to a first embodiment of the present invention is shown;

[0079] Figure 2A flow chart of a method for controlling cryoablation temperature under low temperature operation state in the second embodiment of the present invention is shown;

[0080] Figure 3 A flow chart of a method for controlling cryoablation temperature in a rewarming operation state according to a third embodiment of the present invention is shown;

[0081] Figure 4 A flow chart of a method for adjusting a phase separation valve according to a fourth embodiment of the present invention is shown;

[0082] Figure 5 A schematic diagram of a cryoablation temperature control device according to a fifth embodiment of the present invention is shown;

[0083] Figure 6 A schematic diagram of an adjustment module of a cryoablation temperature control device according to a sixth embodiment of the present invention is shown. DETAILED DESCRIPTION

[0084] The following will describe the implementation methods of the present invention in detail with reference to the accompanying drawings and embodiments, so that the implementation process of how the present invention applies technical means to solve technical problems and achieve technical effects can be fully understood and implemented accordingly. It should be noted that as long as there is no conflict, the various embodiments of the present invention and the various features in the embodiments can be combined with each other, and the technical solutions formed are all within the protection scope of the present invention.

[0085] Embodiment 1

[0086] In order to solve the above technical problems existing in the prior art, an embodiment of the present invention provides a cryoablation temperature control method. Figure 1 A flow chart showing a cryoablation temperature control method is shown, referring to Figure 1 The cryoablation temperature control method of this embodiment includes the following steps:

[0087] S101, obtaining a real-time temperature value and a preset target temperature value of the ablation needle.

[0088] S102, adjusting the openings of the cold working medium output proportional valve and the hot working medium output proportional valve according to the difference between the real-time temperature value and the target temperature value, so that the real-time temperature value reaches the target temperature value.

[0089] S103, maintaining the openings of the cold working medium output proportional valve and the hot working medium output proportional valve unchanged.

[0090] The embodiment of the present invention can be applied to the cryosurgery manual system to achieve fine-tuning of the temperature of the ablation needle. Generally, according to the actual surgical needs, several temperature measuring needles can be inserted into the tissue around the ablation needle. For example, four temperature measuring needles can be set near the ablation needle to measure the temperature of different areas of the tissue. For example, a temperature measuring needle can be inserted near the aorta around the target tissue or other tissue boundary positions that need to be protected. The temperature of the measured tissue can be paid attention to to prevent frostbite or freezing of the protected tissue (the ablation needle tip has its own temperature measuring thermocouple, which can complete the temperature measurement function of the ablation needle tip).

[0091] The user can set the target temperature value according to his treatment plan. For example, the current real-time temperature value is -110°C and the preset target temperature value is -120°C.

[0092] Since the real-time temperature value is different from the target temperature value, the opening of the cold fluid output proportional valve and the hot fluid output proportional valve can be adjusted to adjust the temperature of the ablation needle. Generally speaking, in a cryosurgical system, cold fluid and hot fluid are required because the surgical process involves not only cooling operations but also rewarming operations. For example, during the cooling operation, the opening of the hot fluid output proportional valve can be adjusted to 0%, and then the cold fluid output proportional valve can be adjusted to adjust the temperature. During rewarming, the opening of the cold fluid output proportional valve can be adjusted to 0%, and then the hot fluid output proportional valve can be adjusted to adjust the temperature.

[0093] Specifically, the opening to be adjusted can be determined according to the difference between the real-time temperature value and the preset target temperature value. If the difference is small, the opening to be adjusted is also small, and if the difference is large, the opening to be adjusted is also large.

[0094] If the current real-time temperature value reaches the preset target temperature value, the openings of the cold working fluid output proportional valve and the hot working fluid output proportional valve are maintained unchanged.

[0095] Generally speaking, the temperature required for cryosurgery is between -196°C and 80°C. The cryosurgery in the embodiment of the present invention adopts a cold fluid output proportional valve and a hot fluid output proportional valve. By adjusting the cold fluid output proportional valve and the hot fluid output proportional valve, the amount of output cold fluid and hot fluid can be adjusted as needed, so that the temperature of the ablation needle can be adjusted to any temperature between -196°C and 80°C, thereby enabling cryosurgery to have a wider range of application scenarios.

[0096] Compared with the prior art, one or more embodiments of the above scheme may have the following advantages or beneficial effects: first, the real-time temperature value and the preset target temperature value of the ablation needle are obtained; if the real-time temperature value does not reach the target temperature value, the opening of the cold working fluid output proportional valve and the hot working fluid output proportional valve are adjusted according to the difference between the real-time temperature value and the target temperature value, so that the real-time temperature value reaches the target temperature value, and then the opening of the cold working fluid output proportional valve and the hot working fluid output proportional valve is maintained unchanged. By applying the method of the present invention, the temperature output by the ablation needle can be fine-tuned when performing low temperature or rewarming operations during cryosurgery, thereby improving the treatment effect.

[0097] Embodiment 2

[0098] In order to solve the above technical problems existing in the prior art, the embodiment of the present invention introduces a cryoablation temperature control method in more detail on the basis of the first embodiment. Figure 2 A flow chart showing a cryoablation temperature control method is shown. Figure 2 The cryoablation temperature control method of this embodiment includes:

[0099] S201, determining that the current state is a low temperature operation state.

[0100] S202, obtaining the real-time temperature value and the preset target temperature value of the ablation needle.

[0101] When implementing the embodiment of the present invention, since the cold medium may change from liquid to gas, for example, the cold medium is liquid nitrogen, it will change from liquid nitrogen to gaseous nitrogen when exchanging heat with the ablation needle. At this time, the temperature of the ablation needle may change. Therefore, it is necessary to obtain the real-time temperature of the ablation needle at any time to determine whether the real-time temperature value of the ablation needle is equal to the preset target temperature value.

[0102] S203, controlling and adjusting the cold working medium output proportional valve and the hot working medium output proportional valve, so that the opening of the hot working medium output proportional valve is reduced to 0%, and the opening of the cold working medium output proportional valve is increased to 100%.

[0103] This embodiment is only used as an example. In actual implementation, the order of step S202 and step S203 should not be limited. That is to say, after determining that the current operating state is low temperature, the cold working fluid output proportional valve and the hot working fluid output proportional valve can be adjusted to reduce the opening of the hot working fluid output proportional valve to 0% and increase the opening of the cold working fluid output proportional valve to 100%, and then determine the target temperature value.

[0104] S204, determining whether the real-time temperature value is equal to the target temperature value, if yes, returning to step S202, otherwise, executing step S205.

[0105] S205, adjusting the opening of the thermal medium output proportional valve so that the real-time temperature value reaches the target temperature value.

[0106] The opening of the heat medium output proportional valve to be adjusted can be determined according to the algorithm in the prior art. In different temperature ranges, the opening of the heat medium output proportional valve is obtained by adding a constant and adjusting the difference between the target temperature and the minimum temperature.

[0107] For example, when the target temperature is between -146°C and -196°C, the constant is 5, and the opening of the thermal medium output proportional valve should be adjusted as follows:

[0108]

[0109] When the target temperature is between -96℃ and -146℃, the constant is 8, and the opening of the thermal medium output proportional valve should be adjusted as follows:

[0110]

[0111] When the target temperature is between -46℃ and -96℃, the constant is 15, and the opening of the thermal medium output proportional valve should be adjusted as follows:

[0112]

[0113] When the target temperature is between 0℃ and -46℃, the constant is 23, and the opening of the thermal medium output proportional valve should be adjusted as follows:

[0114]

[0115] S206, maintaining the openings of the cold working medium output proportional valve and the hot working medium output proportional valve unchanged.

[0116] During low-temperature operation, first increase the opening of the cold working fluid output proportional valve to 100%, and reduce the opening of the hot working fluid output proportional valve to 0% to keep the temperature at the lowest temperature. Then, start to adjust the hot working fluid output proportional valve according to the difference between the target temperature and the lowest temperature, so that the temperature rises slowly and continuously, thereby achieving temperature fine-tuning during low-temperature operation.

[0117] By applying the method of the present invention, the temperature output by the ablation needle can be fine-tuned during cryogenic operation or rewarming operation in cryo-external surgery, thereby improving the treatment effect. In clinical applications, freezing at -4°C for 4 minutes and then restoring to room temperature can effectively kill skin melanoma tumors; freezing at -40°C for 3 minutes and then quickly rewarming can effectively kill oral palate tumors; freezing at -70°C for 7 minutes and then quickly rewarming can effectively kill bronchial gland tumors.

[0118] Embodiment 3

[0119] In order to solve the above technical problems existing in the prior art, the embodiment of the present invention introduces a cryoablation temperature control method in more detail on the basis of the first embodiment. Figure 3 A flow chart showing a cryoablation temperature control method is shown in FIG. Figure 3 The cryoablation temperature control method of this embodiment includes:

[0120] S301, determining that the current state is a rewarming operation state.

[0121] S302, obtaining the real-time temperature value and the preset target temperature value of the ablation needle.

[0122] S303, controlling and adjusting the cold working medium output proportional valve and the hot working medium output proportional valve, so that the opening of the hot working medium output proportional valve is increased to 100%, and the opening of the cold working medium output proportional valve is reduced to 0%.

[0123] S304, determine whether the real-time temperature value is equal to the target temperature value, if so, return to step S302; otherwise, execute step S305.

[0124] S305, adjusting the opening of the cold medium output proportional valve so that the real-time temperature value reaches the target temperature value.

[0125] The opening of the heat medium output proportional valve to be adjusted can be determined according to the algorithm in the prior art. In different temperature ranges, the opening of the heat medium output proportional valve is obtained by adding a constant and adjusting the difference between the target temperature and the minimum temperature.

[0126] For example, when the target temperature is between 0°C and 20°C, the constant is 13, and the opening of the cold medium output proportional valve should be adjusted as follows:

[0127] The opening of the cold medium output proportional valve = (13 + target temperature - 80) × 100%.

[0128] When the target temperature is between 20℃ and 40℃, the constant is 8, and the opening of the cold medium output proportional valve should be adjusted as follows:

[0129] The opening of the cold medium output proportional valve = (8 + target temperature - 80) × 100%.

[0130] When the target temperature is between 40℃ and 60℃, the constant is 5, and the opening of the cold medium output proportional valve should be adjusted as follows:

[0131] The opening of the cold medium output proportional valve = (5 + target temperature - 80) × 100%.

[0132] When the target temperature is between 60℃ and 80℃, the constant is 0, and the opening of the cold medium output proportional valve should be adjusted as follows:

[0133] The opening of the cold medium output proportional valve = (target temperature - 80) × 100%.

[0134] S306, maintaining the openings of the cold working medium output proportional valve and the hot working medium output proportional valve unchanged.

[0135] During the rewarming operation, first increase the opening of the hot working fluid output proportional valve to 100%, and reduce the opening of the cold working fluid output proportional valve to 0%, so that the temperature is maintained at the highest temperature. Then, start to adjust the cold working fluid output proportional valve according to the difference between the target temperature and the lowest temperature, so that the temperature is slowly and continuously reduced, thereby achieving temperature fine-tuning during the rewarming operation.

[0136] By applying the method of the embodiment of the present invention, it is possible to fine-tune the temperature output by the ablation needle during the rewarming operation in cryosurgery, thereby improving the treatment effect.

[0137] Embodiment 4

[0138] Usually, in order to keep the ablation needle in a cooling state at all times during low-temperature operation, it is necessary to continuously supply cold working fluid to the ablation needle. Here, the cold working fluid is liquid nitrogen as an example. After heat exchange with the ablation needle, liquid nitrogen will be partially or completely converted into gaseous nitrogen. If nitrogen is always present, the temperature of the ablation needle will rise. At this time, more liquid nitrogen will be needed to lower the temperature of the ablation needle, and the consumption of liquid nitrogen will be large. In order to solve the technical problems in the existing technology, the embodiment of the present invention introduces in more detail the method of adjusting the phase separation valve during cryosurgery to exclude nitrogen and reduce the consumption of liquid nitrogen. Figure 4 A flow chart showing a method for adjusting a phase separation valve is shown. Figure 4 , the method for adjusting the phase separation valve of this embodiment includes:

[0139] S401, start the cryosurgery system.

[0140] The embodiment of the present invention adopts a single-channel cryosurgery system. Compared with the existing multi-channel ablation system, the single-channel system has reduced equipment complexity, smaller size, and more flexible operation.

[0141] S402, determining to perform low temperature operation.

[0142] It is worth noting that the embodiments of the present invention are only applicable to operations at low temperatures.

[0143] S403, check whether there is an abnormality in the feedback temperature measurement circuit of the phase separation valve. If yes, execute step S405; otherwise, execute step S404. If there is an abnormality in the feedback temperature of the phase separation valve, such as the phase separation valve temperature measurement circuit is broken or the temperature measurement thermocouple is damaged, the real-time temperature at the phase separation valve cannot be accurately measured, so the temperature cannot be used to characterize the state of liquid nitrogen flowing through the phase separation valve. In order not to affect the surgical treatment effect, the phase separation valve needs to be kept open.

[0144] S404, closing or opening the phase separation valve according to the feedback temperature.

[0145] Among them, step S404 includes: A. when the feedback temperature is greater than -120°C, opening the phase separation valve; B. when the feedback temperature is less than or equal to -120°C and the temperature of the ablation needle is less than or equal to -150°C, closing the phase separation valve; C. when the temperature of the ablation needle is greater than -150°C, maintaining the state of the phase separation valve unchanged.

[0146] When there is no abnormality in the phase separation valve feedback temperature measurement loop, the feedback temperature can be obtained. Different feedback temperatures require different operations.

[0147] If the feedback temperature is greater than -120, the phase separation valve is opened to release the nitrogen to cool the ablation needle.

[0148] When the feedback temperature is less than or equal to -120℃ and the ablation needle temperature is less than or equal to -150℃, the temperature of the ablation needle tip is low and the phase separation feedback temperature is low, indicating that the pipeline is almost entirely filled with liquid nitrogen. Therefore, the preset time is extended, for example, a delay of 3 seconds, and the feedback temperature is continuously measured within these 3 seconds, and the feedback temperature is always less than -120℃. At this time, the phase separation valve is closed to save liquid nitrogen. After closing the phase separation valve, there is gas with a temperature higher than -196℃ in the pipeline, so the feedback temperature and the ablation needle temperature will gradually increase. When the ablation needle temperature is greater than -150℃, the phase separation valve state needs to be maintained to ensure that the temperature drops rapidly.

[0149] In other cases, no action is taken.

[0150] S405, opening the phase separation valve.

[0151] When an abnormality occurs in the feedback temperature measurement circuit of the phase separation valve, the feedback temperature cannot be measured, so the phase separation valve is kept open, allowing the cold working fluid in the cold tank to continue to cool the ablation needle.

[0152] Embodiment 4 is different from the prior art in which the phase separation valve is always kept open. Since the ablation needle needs to be kept in a cooled state, the consumption of liquid nitrogen is large and the needle tip pressure is high. Embodiment 4 is to discharge the nitrogen in the liquid nitrogen by opening or closing the phase separation valve at intervals during the operation, thereby reducing the temperature of the ablation needle and saving liquid nitrogen.

[0153] The fourth embodiment and the first embodiment do not have a sequential order, and can be performed in parallel during the manual process, that is, the temperature adjustment and the opening or closing of the phase separation valve can be performed at the same time.

[0154] In one embodiment, after step S401 starts the cryosurgery system, the method further includes: D, opening a boost valve of a cold tank for containing a cold working medium to increase the pressure in the cold tank; E, determining whether the pressure value in the cold tank is within a first preset pressure value range; F, closing the boost valve when the pressure value in the cold tank is within the first preset pressure value range, otherwise opening the boost valve.

[0155] Generally, the working pressure of the cold tank is 930kPa to 990kPa. When the cold tank is working, its internal pressure keeps changing. The embodiment of the present invention can detect the pressure in the cold tank in real time. For example, the first preset pressure value range is greater than 990kPa. When the pressure in the cold tank is greater than 990kPa, the cold tank booster valve is closed and the pressure in the cold tank is not further increased. When the pressure in the cold tank is between 930kPa and 990kPa, the current action state is maintained to maintain the pressure in the cold tank at the current pressure. When the pressure in the cold tank is lower than 930kPa, the booster valve is opened to increase the pressure in the cold tank. The goal of this embodiment is to keep the pressure in the cold tank between 930kPa and 990kPa.

[0156] In one of the embodiments, after starting the cryosurgery system in step S401, the method further includes: G, opening a boost valve of a cold tank for containing a cold working fluid to increase the pressure in the cold tank; E, determining whether the pressure value in the cold tank is within a second preset pressure value range; H, when the pressure value in the cold tank is greater than a maximum value in the second preset pressure value range, opening a regulating valve and an air release valve of the cold tank; I, when the pressure value in the cold tank is within the second preset pressure value range, opening the regulating valve and closing the air release valve at the same time; J, when the pressure value in the cold tank is less than a minimum value in the second preset pressure value range, closing the regulating valve and the air release valve.

[0157] Generally, the working pressure of the cold tank is 930kPa to 990kPa. For example, the second preset pressure value range is between 990kPa and 1050kPa. When the pressure value in the cold tank is greater than 1050kPa, the regulating valve and the venting valve of the cold tank are opened; when the pressure value in the cold tank is between 990kPa and 1050kPa, the regulating valve is opened and the venting valve is closed at the same time; when the pressure value in the cold tank is less than 990kPa, the regulating valve and the venting valve are closed. This embodiment can prevent the pressure from exceeding the working pressure due to the failure of the boost valve control and continuous boosting or excessive boosting.

[0158] By applying the method of the present invention, it is possible to remove nitrogen from liquid nitrogen at any time during cryosurgery according to the current temperature, so that the ablation needle can be cooled quickly.

[0159] Embodiment 5

[0160] In order to solve the above technical problems existing in the prior art, an embodiment of the present invention further provides a cryoablation temperature control device. Figure 5 FIG. 5 shows a structural block diagram of a cryoablation temperature control device 50. Figure 5 The cryoablation temperature control device 50 of this embodiment includes:

[0161] A temperature acquisition module 501 is used to acquire a real-time temperature value and a preset target temperature value of the ablation needle;

[0162] The regulating module 502 is used to regulate the opening of the cold working medium output proportional valve and the hot working medium output proportional valve according to the difference between the real-time temperature value and the target temperature value, so that the real-time temperature value reaches the target temperature value;

[0163] The maintaining module 503 is used to maintain the opening of the cold working medium output proportional valve and the hot working medium output proportional valve unchanged.

[0164] The cryoablation temperature control device of this embodiment corresponds to the cryosurgery system of the first embodiment, and uses corresponding modules to achieve fine-tuning of the temperature to achieve the technical effects of the first embodiment, which will not be described in detail here.

[0165] Embodiment 6

[0166] In order to solve the above technical problems existing in the prior art, the present invention further provides a cryoablation temperature control device based on the fifth embodiment. Figure 5 The cryoablation temperature control device 50 of this embodiment further includes:

[0167] The low temperature operation determination module 504 is used to determine that the current state is a low temperature operation state before obtaining the real-time temperature value and the preset target temperature value of the ablation needle.

[0168] like Figure 6 As shown, the adjustment module 502 includes:

[0169] The first control submodule 5021 is used to control and adjust the cold working medium output proportional valve and the hot working medium output proportional valve, so that the opening of the hot working medium output proportional valve is reduced to 0%, and the opening of the cold working medium output proportional valve is increased to 100%;

[0170] A first judging module 5022, configured to judge whether the real-time temperature value is equal to the target temperature value;

[0171] The first regulating module 5023 is used to regulate the opening of the thermal medium output proportional valve when the real-time temperature value is not the target temperature value, so that the real-time temperature reaches the target temperature.

[0172] Furthermore, the device also includes:

[0173] The high temperature operation determination module 505 is used to determine that the current state is a rewarming operation state before obtaining the real-time temperature value and the preset target temperature value of the ablation needle.

[0174] Accordingly, the adjustment module 502 further includes:

[0175] The second control submodule 5024 controls and adjusts the cold working medium output proportional valve and the hot working medium output proportional valve, so that the opening of the hot working medium output proportional valve increases to 100%, and the opening of the cold working medium output proportional valve decreases to 0%;

[0176] The second judgment module 5025 is used to judge whether the real-time temperature is the target temperature;

[0177] The second regulating module 5026 is used for regulating the opening of the cold medium output proportional valve if the temperature is not the target temperature, so that the real-time temperature reaches the target temperature.

[0178] Furthermore, the device also includes:

[0179] A start module 506 is used to start the cryosurgery system;

[0180] A state determination module 507 is used to determine whether to perform a low temperature operation;

[0181] A detection module 508 is used to detect whether there is an abnormality in the feedback temperature measurement circuit of the phase separation valve when performing low-temperature operation;

[0182] The phase separation valve regulating module 509 is used to close or open the phase separation valve according to the feedback temperature when there is no abnormality in the feedback temperature measurement loop of the phase separation valve; and to open the phase separation valve when there is an abnormality in the feedback temperature measurement loop of the phase separation valve.

[0183] Specifically, the phase separation valve regulating module 509 is specifically used for:

[0184] When the feedback temperature is greater than -120°C, the phase separation valve is opened;

[0185] When the feedback temperature is less than or equal to -120° C. and the temperature of the ablation needle is less than or equal to -150° C., closing the phase separation valve;

[0186] When the temperature of the ablation needle is greater than -150°C, the state of the phase separation valve is maintained unchanged.

[0187] Furthermore, the device also includes:

[0188] The first cold tank pressure regulating module 510 is used to open the boost valve of the cold tank for containing the cold working medium to increase the pressure in the cold tank; and to determine whether the pressure value in the cold tank is within the first preset pressure value range; and when the pressure value in the cold tank is within the first preset pressure value range, close the boost valve, otherwise open the boost valve.

[0189] Furthermore, the device also includes:

[0190] The second cold tank pressure regulating module 511 is used to open the boost valve of the cold tank for containing the cold working medium to increase the pressure in the cold tank; and to determine whether the pressure value in the cold tank is within a second preset pressure value range; and when the pressure value in the cold tank is greater than the maximum value of the second preset pressure value range, open the regulating valve and the air release valve of the cold tank; and when the pressure value in the cold tank is within the second preset pressure value range, open the regulating valve and close the air release valve at the same time; and when the pressure value in the cold tank is less than the minimum value of the second preset pressure value range, close the regulating valve and the air release valve.

[0191] This embodiment can achieve fine-tuning of the temperature output by the ablation needle during the cooling and rewarming process, and can also recycle hot working fluid to avoid waste of resources.

[0192] Embodiment 7

[0193] In order to solve the above technical problems existing in the prior art, an embodiment of the present invention provides a cryosurgery system.

[0194] The system includes the device as described in Example 5 or 6, which is used to implement the method as described in any one of Examples 1 to 4.

[0195] The system further comprises a processor, wherein the processor comprises a microcontroller unit (MCU) and a field-programmable gate array (PFGA).

[0196] The embodiment of the present invention combines MCU with FPGA as a processor, which can achieve better control of the system.

[0197] The system also includes some common structures of frozen manual systems, such as encryption module, alarm module, human-computer interaction module, etc., which will not be described here.

[0198] Embodiment 8

[0199] To solve the above technical problems existing in the prior art, an embodiment of the present invention provides a storage medium. The storage medium provided by the embodiment of the present invention stores a computer program, which implements the steps of the method described in Embodiments 1 to 4 when executed by a processor.

[0200] Although the embodiments disclosed in the present invention are as above, the contents described are only embodiments adopted for facilitating the understanding of the present invention and are not intended to limit the present invention. Any technician in the technical field to which the present invention belongs can make any modifications and changes in the form and details of the implementation without departing from the spirit and scope disclosed in the present invention, but the protection scope of the present invention shall still be subject to the scope defined in the attached claims.

Claims

1. A cryoablation temperature control device, characterized in that: The device comprises: A temperature acquisition module is used to obtain the real-time temperature value of the ablation needle and the preset target temperature value; an adjusting module, for adjusting the opening of the cold working medium output proportional valve and the hot working medium output proportional valve according to the difference between the real-time temperature value and the target temperature value, so that the real-time temperature value reaches the target temperature value; A maintaining module, used for maintaining the opening of the cold working medium output proportional valve and the hot working medium output proportional valve unchanged; Among them, when the target temperature is between 0℃ and 20℃, the constant is 13, and the formula for adjusting the opening of the cold working medium output proportional valve is: The opening of the cold medium output proportional valve = (13 + target temperature - 80) × 100%; When the target temperature is between 20℃ and 40℃, the constant is 8, and the formula for adjusting the opening of the cold working medium output proportional valve is: The opening of the cold medium output proportional valve = (8 + target temperature - 80) × 100%; When the target temperature is between 40℃ and 60℃, the constant is 5, and the formula for adjusting the opening of the cold working medium output proportional valve is: The opening of the cold medium output proportional valve = (5 + target temperature - 80) × 100%; When the target temperature is between 60℃ and 80℃, the constant is 0, and the formula for adjusting the opening of the cold working medium output proportional valve is: The opening of the cold medium output proportional valve = (target temperature - 80) × 100%.

2. The device according to claim 1, characterized in that The device comprises: The low temperature operation determination module is used to determine that the current state is a low temperature operation state before obtaining the real-time temperature value and the preset target temperature value of the ablation needle.

3. The device according to claim 2, characterized in that The adjustment module comprises: The first control submodule is used to control and adjust the cold working medium output proportional valve and the hot working medium output proportional valve, so that the opening of the hot working medium output proportional valve is reduced to 0%, and the opening of the cold working medium output proportional valve is increased to 100%; A first judging module, used for judging whether the real-time temperature value is equal to the target temperature value; The first regulating module is used for regulating the opening of the thermal medium output proportional valve when the real-time temperature value is not the target temperature value, so that the real-time temperature reaches the target temperature.

4. The device according to claim 1, characterized in that The device comprises: The high temperature operation determination module is used to determine that the current state is a rewarming operation state before obtaining the real-time temperature value and the preset target temperature value of the ablation needle.

5. The device according to claim 4, characterized in that The adjustment module also includes: The second control submodule controls and adjusts the cold working fluid output proportional valve and the hot working fluid output proportional valve, so that the opening of the hot working fluid output proportional valve increases to 100% and the opening of the cold working fluid output proportional valve decreases to 0%; A second judgment module is used to judge whether the real-time temperature is the target temperature; The second regulating module is used for regulating the opening of the cold medium output proportional valve if the temperature is not the target temperature, so that the real-time temperature reaches the target temperature.

6. The device according to claim 1, characterized in that The device also includes: A start module, used for starting the cryosurgery system; A state judgment module is used to determine whether to perform low temperature operation; A detection module, used to detect whether there is an abnormality in the feedback temperature measurement circuit of the phase separation valve when performing low-temperature operation; The phase separation valve regulating module is used to close or open the phase separation valve according to the feedback temperature when there is no abnormality in the feedback temperature measurement circuit of the phase separation valve; and to open the phase separation valve when there is an abnormality in the feedback temperature measurement circuit of the phase separation valve.

7. The device according to claim 6, characterized in that The regulating phase separation valve module is specifically used for: When the feedback temperature is greater than -120°C, the phase separation valve is opened; When the feedback temperature is less than or equal to -120° C. and the temperature of the ablation needle is less than or equal to -150° C., closing the phase separation valve; When the temperature of the ablation needle is greater than -150° C., the state of the phase separation valve is maintained unchanged.

8. The device according to claim 6, characterized in that The device also includes: The first cold tank pressure regulating module is used to open the boosting valve of the cold tank for containing the cold working medium to increase the pressure in the cold tank; and to determine whether the pressure value in the cold tank is within the first preset pressure value range; and when the pressure value in the cold tank is within the first preset pressure value range, close the boosting valve, otherwise open the boosting valve.

9. The device according to claim 6, characterized in that The device also includes: The second cold tank pressure regulating module is used to open the boost valve of the cold tank for containing the cold working medium to increase the pressure in the cold tank; and to determine whether the pressure value in the cold tank is within a second preset pressure value range; and when the pressure value in the cold tank is greater than the maximum value of the second preset pressure value range, open the regulating valve and the air release valve of the cold tank; and when the pressure value in the cold tank is within the second preset pressure value range, open the regulating valve and close the air release valve at the same time; and when the pressure value in the cold tank is less than the minimum value of the second preset pressure value range, close the regulating valve and the air release valve.

10. A cryosurgery system, characterized in that: The system comprises the device according to any one of claims 1 to 9.

11. The system according to claim 10, characterized in that The system further comprises a processor, wherein the processor comprises a microcontroller unit and a field programmable gate array.

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