Tip protection device and chemiluminescence immunoassay analyzer

Abstract

The present invention belongs to the technical field of biochemical analysis and discloses a tip protection device and a chemiluminescence immunoassay instrument. The chemical analyzer includes a sample needle mechanism, a tip storage device, and a tip protection device. The tip protection device is arranged above the tip storage device; the tip protection device includes a base plate, a switch mechanism, and a collision mechanism. An opening is provided on the base plate, and the opening faces the tip storage device; the switch mechanism is arranged on the base plate and is configured to cover or expose the opening; the collision mechanism is movably located above the base plate and is fixedly connected to the sample needle mechanism. The collision mechanism is configured to move with the sample needle mechanism and collide with the switch mechanism to drive the switch mechanism to cover or expose the opening, so that the tip is always kept clean during the sample needle addition process, thereby ensuring the accuracy of subsequent sample detection data.

Description

Technical Field

[0001] The present invention relates to the technical field of biochemical analysis, and in particular to a pipette tip protection device and a chemiluminescence immunoassay instrument. Background Art

[0002] With the rapid development of immunology and the continuous innovation of science and technology, new immunological technologies have emerged. Emerging assay technologies have also promoted the full automation of immunoassays, leading to the emergence of a large number of advanced automatic testing instruments. Based on this, the measurement precision and data accuracy of fully automated chemiluminescence immunoassay analyzers often depend on the machining precision and precise operating conditions of each module of the instrument.

[0003] The main working principle of the chemiluminescence immunoassay is chemiluminescence immunoassay, which combines highly sensitive chemiluminescence measurement technology with highly specific immune reactions. It is used for the detection and analysis of various antigens, antibodies, hormones, enzymes, vitamins and drugs. It has both the specificity of immune reactions and the high sensitivity of chemiluminescence reactions. The operation method is simple and convenient, with good repeatability, no pollution, and is widely used.

[0004] Existing chemiluminescent immunoassays include a sample needle, a tip storage device, reagents, a drive mechanism, and a control unit. When operating within the instrument, the sample needle has a pre-set motion trajectory for the process of removing the tip, sampling, and adding the sample. From the moment the tip is removed to the moment it is sampled, it passes through the tip storage device, and again from the moment it is sampled to the moment it is added. The control unit controls the drive mechanism according to this pre-set motion trajectory, driving the sample needle to sequentially remove the tip, sample, and add the sample. During sampling, sample residue may remain on the outer wall of the tip. During the sample addition process after sampling, the sample on the outer wall of the tip may drip into the clean tip below the sample needle's motion trajectory, contaminating the tip and affecting the accuracy of subsequent sample test data.

[0005] Therefore, there is an urgent need to design a pipette tip protection device and a chemiluminescence immunoassay to solve the problem of pipette tip contamination affecting the accuracy of subsequent sample detection data. Summary of the Invention

[0006] One object of the present invention is to provide a pipette tip protection device that can prevent test samples from dripping into a pipette tip storage device and contaminating clean pipette tips, thereby ensuring the accuracy of subsequent sample test data.

[0007] Another object of the present invention is to provide a chemiluminescence immunoassay analyzer that can ensure the accuracy of subsequent sample detection data.

[0008] To achieve this object, the present invention adopts the following technical solutions:

[0009] A pipette tip protection device is provided above the pipette tip storage device, and the pipette tip protection device comprises:

[0010] A bottom plate, wherein an opening is formed on the bottom plate, and the opening faces the suction head storage device;

[0011] a switch mechanism disposed on the bottom plate, the switch mechanism being configured to cover or expose the opening; and

[0012] The collision mechanism is movably located above the bottom plate, and is configured to collide with the switch mechanism to drive the switch mechanism to cover or expose the opening.

[0013] Optionally, the switch mechanism includes:

[0014] a baffle, slidably disposed on the bottom plate; and

[0015] The transmission assembly is arranged on the base plate, the baffle is fixedly connected to the transmission assembly, and the transmission assembly is configured to drive the baffle to perform reciprocating linear motion to cover or expose the opening.

[0016] Optionally, the transmission assembly includes:

[0017] A first synchronous pulley assembly is arranged on the base plate along a first direction;

[0018] A second synchronous pulley assembly is disposed on the base plate along a second direction, the second direction being perpendicular to the first direction; a first end of the second synchronous pulley assembly is drivingly connected to the second end of the first synchronous pulley assembly, and the baffle is fixedly connected to the second synchronous pulley assembly; and

[0019] The toggle assembly is arranged on the above-mentioned first synchronous pulley assembly. The above-mentioned toggle assembly is configured to collide with the above-mentioned collision mechanism to drive the above-mentioned first synchronous pulley assembly and the above-mentioned second synchronous pulley assembly to drive the above-mentioned baffle to cover or expose the above-mentioned opening.

[0020] Optionally, the first synchronous pulley assembly includes a first transmission wheel and a second transmission wheel that are spaced apart, and a first synchronous belt wound around the first transmission wheel and the second transmission wheel, and the first synchronous belt is tensioned by the first transmission wheel and the second transmission wheel.

[0021] The above-mentioned second synchronous pulley assembly includes a third transmission wheel and a fourth transmission wheel arranged at intervals, and a second synchronous belt wound around the above-mentioned third transmission wheel and the above-mentioned fourth transmission wheel, and the above-mentioned second synchronous belt is jointly tensioned by the above-mentioned third transmission wheel and the above-mentioned fourth transmission wheel, the above-mentioned third transmission wheel and the above-mentioned second transmission wheel are coaxial and fixedly arranged, and the above-mentioned baffle is fixedly connected to the above-mentioned second synchronous belt.

[0022] Optionally, the toggle assembly includes:

[0023] a first shifting rod fixedly connected to the first transmission wheel, the first shifting rod being configured to collide with the collision mechanism to allow the baffle to be exposed from the opening; and

[0024] The second shifting rod is fixedly connected to the second transmission wheel. The second shifting rod is configured to collide with the collision mechanism so that the baffle covers the opening.

[0025] Optionally, the switch mechanism further comprises a limiting assembly, which is fixedly connected to the base plate and located on one side of the toggle assembly, and is configured to limit the toggle assembly.

[0026] Optionally, one of the above-mentioned limiting assembly and the above-mentioned toggling assembly is provided with a limiting groove, and the other is provided with a limiting protrusion, and the above-mentioned limiting protrusion can be engaged with the above-mentioned limiting groove.

[0027] Optionally, the switch mechanism further comprises a slider and a slide rail, one of the baffle and the bottom plate is provided with the slider, and the other is provided with the slide rail, and the slide rail is slidably connected to the slider.

[0028] Optionally, the collision mechanism includes a rolling member, and the rolling member is used to collide with the switch mechanism.

[0029] A chemiluminescent immunoassay analyzer comprises a sample needle mechanism, a tip storage device and the tip protection device. The collision mechanism of the tip protection device is fixedly connected to the sample needle mechanism and can move along with the movement of the sample needle mechanism.

[0030] Beneficial effects of the present invention:

[0031] The present invention provides a tip protection device, which is arranged above a tip storage device. The tip protection device includes a base plate, a switch mechanism arranged on the base plate, and a collision mechanism movably located above the base plate. The collision mechanism collides with the switch mechanism, so that when a sample needle takes out the tip, the switch mechanism can expose an opening facing the tip storage device, and the sample needle can pass through the opening to take out the tip; during the sample addition process after the sample needle takes out the tip, the switch mechanism can cover the opening facing the tip storage device, so as to prevent the test sample on the outer wall of the tip from dripping into the tip storage device after sampling, thereby avoiding contamination of the clean tip, and further improving the accuracy of the sample detection data.

[0032] The present invention also provides a chemiluminescence immunoassay analyzer, comprising a sample needle mechanism, a tip storage device, and the above-mentioned tip protection device. The collision mechanism is fixedly connected to the sample needle mechanism, so that when the sample needle mechanism moves, it directly drives the collision mechanism to move to collide with the switch mechanism, thereby realizing that the baffle covers or exposes the opening on the bottom plate, preventing the test sample on the outer wall of the tip from dripping into the tip storage device after sampling, thereby avoiding contamination of the clean tip, thereby improving the accuracy of the sample detection data, and no other electrical components are introduced, no unnecessary connecting wires, and the structure is simple. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Figure 1 1 is a schematic diagram of the partial structure of a chemiluminescence immunoassay analyzer provided in a specific embodiment of the present invention;

[0034] Figure 2 This is a schematic diagram of the structure of the suction head protection device provided in a specific embodiment of the present invention. Figure 1 ;

[0035] Figure 3 This is a schematic diagram of the structure of the suction head protection device provided in a specific embodiment of the present invention. Figure 2 ;

[0036] Figure 4 is a structural schematic diagram of a first transmission wheel, a second transmission wheel, or a third transmission wheel provided in a specific embodiment of the present invention;

[0037] Figure 5 is a structural diagram of a connection block provided in a specific embodiment of the present invention;

[0038] Figure 6 This is an exploded view of the structure of the base plate and the fixed shaft provided in a specific embodiment of the present invention;

[0039] Figure 7 is a structural schematic diagram of a first shift lever or a second shift lever provided in a specific embodiment of the present invention;

[0040] Figure 8 This is a schematic structural diagram of the initial position of the suction tip protection device provided by a specific embodiment of the present invention;

[0041] Figure 9 2. It is a schematic structural diagram of a pipette tip protection device in a pipette tip removal state provided by a specific embodiment of the present invention;

[0042] Figure 10 This is a schematic structural diagram of a pipette tip protection device in a sampling state provided by a specific embodiment of the present invention;

[0043] Figure 11 This is a schematic structural diagram of a pipette tip protection device from a sampling state to a sample adding state provided by a specific embodiment of the present invention;

[0044] Figure 12 It is a schematic structural diagram of the pipette tip protection device in the sample adding state provided by a specific embodiment of the present invention.

[0045] In the picture:

[0046] 10. Bottom plate; 11. Opening; 12. First fixing hole; 13. Second fixing hole; 14. Oval hole;

[0047] 20. Switch mechanism; 21. Baffle;

[0048] 22. Transmission components;

[0049] 221, first synchronous pulley assembly; 2211, first transmission pulley; 2212, second transmission pulley; 2213, first synchronous belt;

[0050] 222, second synchronous pulley assembly; 2221, third transmission pulley; 2222, fourth transmission pulley; 2223, second synchronous belt;

[0051] 223, toggle assembly; 2231, first toggle lever; 2232, second toggle lever; 2233, main body; 22331, first countersunk hole; 22332, boss; 2234, toggle portion; 224, connecting block; 2241, threaded hole; 2242, second countersunk hole;

[0052] 225, first fixed axis; 226, second fixed axis; 227, third fixed axis; 228, first through hole;

[0053] 23. Slider; 24. Slide rail; 25. Limiting assembly; 26. Limiting groove; 27. Limiting protrusion; 28. Bracket; 29. ​​Connecting piece;

[0054] 30. Collision mechanism; 31. Rolling element; 32. Connecting element;

[0055] 200. Sample needle mechanism; 210. Sample needle. DETAILED DESCRIPTION

[0056] The present invention will be further described in detail below with reference to the accompanying drawings and examples. It will be understood that the specific embodiments described herein are intended only to illustrate the present invention and are not intended to limit the present invention. It should also be noted that, for ease of description, the accompanying drawings only illustrate portions relevant to the present invention, not all structures.

[0057] In the description of the present invention, unless otherwise expressly specified or limited, the terms "connected," "connected," and "fixed" should be understood in a broad sense. For example, they may refer to fixed connections, detachable connections, or integration; mechanical connections or electrical connections; direct connections or indirect connections through an intermediate medium; and internal communication between two components or interaction between two components. Those skilled in the art will understand the specific meanings of the above terms in the present invention in specific circumstances.

[0058] In the present invention, unless otherwise expressly specified or limited, a first feature being "above" or "below" a second feature may include the first and second features being in direct contact, or may include the first and second features being in contact not directly but through another feature between them. Furthermore, a first feature being "above," "above," and "above" a second feature may include the first feature being directly above or obliquely above the second feature, or may simply mean that the first feature is higher in level than the second feature. A first feature being "below," "below," and "below" a second feature may include the first feature being directly below or obliquely below the second feature, or may simply mean that the first feature is lower in level than the second feature.

[0059] In the description of this embodiment, the terms "upper," "lower," "right," and other orientations or positional relationships are based on the orientations or positional relationships shown in the accompanying drawings and are intended solely for ease of description and simplified operation. They do not indicate or imply that the devices or components referred to must have, be constructed, or operate in a specific orientation. Therefore, they should not be construed as limitations on the present invention. Furthermore, the terms "first" and "second" are used solely for descriptive purposes and have no special meanings.

[0060] This embodiment provides a chemiluminescent immunoassay analyzer, such as Figure 1 As shown, the chemiluminescence immunoassay analyzer includes a sample needle mechanism 200, a tip storage device, and a tip protection device. The tip protection device is arranged above the tip storage device. The sample needle mechanism 200 is located above the tip protection device. The tip storage device is used to store clean tips. The tip protection device is used to protect the tips in the tip storage device. The sample needle mechanism 200 includes a sample needle 210. The sample needle 210 can suck up the tip and then suck up the sample through the tip.

[0061] Through the above structure, when conducting a chemiluminescent immunoassay experiment, while the sample needle 210 is removing the tip, the sample needle mechanism 200 drives the sample needle 210 to move above the tip protection device. At this time, the sample needle 210 can extend into the tip storage device to absorb the tip. After the tip is removed, the tip moves with the sample needle 210 to the sampling area for sampling and then moves to the tip storage device for sample addition. The tip protection device protects the tip storage device to prevent the test sample on the outer wall of the tip from dripping into the tip storage device after sampling, thereby avoiding contamination of the clean tip and improving the accuracy of the sample test data. After the tip is added, the tip moves with the sample needle 210 to the tip disposal device, removes the tip, and returns to the tip storage device for the next round of sample removal and placement.

[0062] In this embodiment, if Figure 2 As shown, the tip protection device includes a base plate 10, a switch mechanism 20, and a collision mechanism 30. When the sample is being removed and placed, the collision mechanism 30 drives the switch mechanism 20 to move, thereby shielding or exposing the tip storage device. This ensures that the tips in the tip storage device remain clean before use, thereby ensuring the accuracy of subsequent sample test data. Specifically, an opening 11 is provided on the base plate 10, and the opening 11 faces the tip storage device. When the sample needle 210 is removing the tip, the tip in the tip storage device can be removed through the opening 11, which is convenient and quick. Furthermore, the switch mechanism 20 is disposed on the base plate 10 and can shield or expose the opening 11. When the sample needle 210 is removing the tip, the switch mechanism 20 exposes the opening 11. After the sample needle 210 takes a sample and during the sample addition process, the switch mechanism 20 shields the opening 11 to protect the tips in the tip storage device. Furthermore, the collision mechanism 30 can be moved above the bottom plate 10 so that the collision mechanism 30 can collide with the switch mechanism 20 during the movement, thereby driving the switch mechanism 20 to cover the opening 11 or expose the opening 11, which is easy to operate. Figure 1 As shown, the collision mechanism 30 is fixedly connected to the sample needle mechanism 200 , so that the collision mechanism 30 can move along with the movement of the sample needle mechanism 200 .

[0063] With the above structure, when the sample is taken out, the tip protection device is in the initial state, that is, the opening 11 is exposed, and the sample needle 210 first comes to the opening 11 and extends into the tip storage device through the opening 11 to take the tip; after the tip is taken out, the tip moves with the sample needle 210 to the sampling position for sampling. During this process, the collision mechanism 30 moves with the sample needle 210 and collides with the switch mechanism 20, thereby driving the switch mechanism 20 to cover the opening 11; after the tip completes sampling, the tip moves with the sample needle 210 to the sample addition area. During this process, since the switch mechanism 20 covers the opening 11, it prevents the test sample remaining on the outer wall of the tip after sampling from dripping onto the tip storage The sample needle 210 is placed in a clean pipette tip in the device, thereby protecting the clean pipette tip and improving the accuracy of the sample detection data; and when the sample needle 210 leaves the top of the pipette tip protection device, the collision mechanism 30 moves with the sample needle 210 and collides with the switch mechanism 20, thereby driving the switch mechanism 20 to expose the opening 11, so that the pipette tip protection device is in the initial state again; after the pipette tip is loaded with the sample, the sample needle 210 drives the pipette tip to move to the pipette tip removal device, removes the pipette tip, and returns to the opening 11 for the next round of sample placement and removal; the above operation is simple and fast, and no electrical components are introduced. The pipette tip can be protected only by a simple mechanical structure, thereby improving the test accuracy.

[0064] In this embodiment, if Figure 2 As shown, the above-mentioned switch mechanism 20 includes a baffle 21 and a transmission assembly 22. The baffle 21 is slidably set on the base plate 10, and can cover or expose the opening 11; the transmission assembly 22 is set on the base plate 10, and the baffle 21 is fixedly connected to the transmission assembly 22, so that the transmission assembly 22 can drive the baffle 21 to perform reciprocating linear motion, thereby covering or exposing the opening 11, and then realizing the opening or closing of the nozzle storage device.

[0065] Optionally, the switch mechanism 20 further includes a slider 23 and a slide rail 24. One of the baffle 21 and the base plate 10 is provided with the slider 23, and the other is provided with the slide rail 24. The slide rail 24 is slidably connected to the slider 23, thereby enabling a sliding connection between the baffle 21 and the base plate 10. Optionally, in this embodiment, the switch mechanism 20 further includes a bracket 28. The bracket 28 is fixedly connected to the base plate 10. One of the slide rail 24 and the slider 23 is fixedly connected to the bracket 28. The bracket 28 raises the slide rail 24 or the slider 23, thereby raising the baffle 21, thereby better matching the connection between the baffle 21 and the transmission assembly 22. Specifically, in this embodiment, the slider 23 is provided on the baffle 21, and the slide rail 24 is provided on the bracket 28, so that the baffle 21 can slide along the slide rail 24 as the transmission assembly 22 moves, thereby enabling the baffle 21 to cover or expose the opening 11.

[0066] Furthermore, if Figure 3As shown, the transmission assembly 22 includes a first synchronous pulley assembly 221, a second synchronous pulley assembly 222 and a toggle assembly 223. The first synchronous pulley assembly 221 moves in a first direction (such as Figure 1 The second synchronous pulley assembly 222 is arranged on the bottom plate 10 to realize the transmission of the transmission component 22 in the first direction; the second synchronous pulley assembly 222 is arranged along the second direction (such as Figure 1 The first end of the second synchronous pulley assembly 222 is connected to the second end of the first synchronous pulley assembly 221, thereby achieving synchronous transmission between the first and second synchronous pulley assemblies 221, 222. The baffle 21 is fixedly connected to the second synchronous pulley assembly 222, thereby achieving movement of the baffle 21 in the second direction. Optionally, a toggle assembly 223 is provided on the first synchronous pulley assembly 221. The toggle assembly 223 can collide with the collision mechanism 30 to drive the first and second synchronous pulley assemblies 221, 222 to drive simultaneously, thereby driving the baffle 21 to cover or expose the opening 11. Through the above structure, after the toggle assembly 223 collides with the collision mechanism 30, it can drive the first synchronous pulley assembly 221 to drive, thereby driving the second synchronous pulley assembly 222 to drive synchronously, thereby driving the baffle 21 to cover or expose the opening 11.

[0067] Alternatively, as Figure 3As shown, the first synchronous pulley assembly 221 includes a first transmission pulley 2211 and a second transmission pulley 2212 spaced apart along a first direction, and a first synchronous belt 2213 wound around the first transmission pulley 2211 and the second transmission pulley 2212. The first synchronous belt 2213 is tensioned by the first transmission pulley 2211 and the second transmission pulley 2212, thereby enabling transmission of the first synchronous pulley assembly 221. Optionally, the second synchronous pulley assembly 222 includes a third transmission pulley 2221 and a fourth transmission pulley 2222 spaced apart along a second direction, and a second synchronous belt 2223 wound around the third transmission pulley 2221 and the fourth transmission pulley 2222. The second synchronous belt 2223 is tensioned by the third transmission pulley 2221 and the fourth transmission pulley 2222, thereby enabling transmission of the second synchronous pulley assembly 222. Optionally, the third transmission wheel 2221 and the second transmission wheel 2212 are coaxial and fixedly arranged, thereby achieving synchronous transmission of the first synchronous pulley assembly 221 and the second synchronous pulley assembly 222. That is, by driving the first transmission wheel 2211, the second transmission wheel 2212, the third transmission wheel 2221, or the fourth transmission wheel 2222 to rotate, the first synchronous belt 2213 and the second synchronous belt 2223 can be simultaneously driven. Optionally, the baffle 21 is fixedly connected to the second synchronous belt 2223, enabling the baffle 21 to perform reciprocating linear motion along the second direction. Preferably, the baffle 21 is perpendicularly connected to the second synchronous belt 2223 to maximize the movement path of the baffle 21, thereby allowing the size of the opening 11 to be reasonably adjusted, thereby reducing the diameter of the transmission wheels and saving space.

[0068] Through the above structure, by driving any one of the transmission wheels to rotate, the first synchronous belt 2213 and the second synchronous belt 2223 can be synchronously driven, so that the baffle 21 can make reciprocating linear motion along the second direction, thereby realizing the shielding and exposure of the opening 11 by the baffle 21.

[0069] Optionally, the first transmission wheel 2211 and the second transmission wheel 2212 are arranged at the same horizontal plane, and the third transmission wheel 2221 and the fourth transmission wheel 2222 are arranged at the same horizontal plane, to facilitate transmission by the transmission assembly 22. In this embodiment, the second transmission wheel 2212 is arranged above the third transmission wheel 2221, that is, the first synchronous pulley assembly 221 is arranged above the second synchronous pulley assembly 222. In other embodiments, adaptive adjustments can also be made, which are not specifically limited here.

[0070] Alternatively, as Figure 3 As shown, a connecting block 224 is provided between the second transmission wheel 2212 and the third transmission wheel 2221. The connecting block 224 is fixedly connected between the second transmission wheel 2212 and the third transmission wheel 2221, and can realize the fixed connection between the second transmission wheel 2212 and the third transmission wheel 2221, so that the second transmission wheel 2212 and the third transmission wheel 2221 rotate synchronously. Figure 4 As shown, the first transmission wheel 2211, the second transmission wheel 2212 and the third transmission wheel 2221 are each provided with a first through hole 228 for fixed connection with other components. Preferably, there are multiple first through holes 228 to improve the stability of the connection.

[0071] Alternatively, as Figure 5 As shown, the connecting block 224 is provided with a threaded hole 2241 and a second countersunk hole 2242, and the bolt passes through the first through hole 228 of the second transmission wheel 2212 and is connected to the threaded hole 2241, so that the second transmission wheel 2212 and the connecting block 224 are fixedly connected; the bolt passes through the second countersunk hole 2242 and the first through hole 228 of the third transmission wheel 2221 and is connected to the nut, so that the third transmission wheel 2221 and the connecting block 224 are fixedly connected, thereby realizing the fixed connection between the second transmission wheel 2212 and the third transmission wheel 2221.

[0072] Alternatively, as Figure 3 As shown, the baffle 21 is an L-shaped structure. Specifically, the baffle 21 includes a vertical portion and a horizontal portion that are vertically connected. The vertical portion is fixedly connected to the second synchronous belt 2223, and the horizontal portion is movably arranged above the opening 11 to cover or expose the opening 11. Specifically, as Figure 2 As shown, the nozzle protection device further includes a connecting piece 29, which is used to connect with the vertical portion of the baffle 21 to secure the baffle 21 to the second synchronous belt 2223. Optionally, the vertical portion of the baffle 21 is provided with a second through hole (not shown in the figure), and the connecting piece 29 is provided with a third through hole (not shown in the figure). By passing a fastener through the second and third through holes in sequence and tightening them, the second synchronous belt 2223 can be clamped and secured between the connecting piece 29 and the vertical portion of the baffle 21, thereby achieving a stable connection between the baffle 21 and the second synchronous belt 2223.

[0073] Alternatively, as Figure 3 and Figure 6 As shown, the transmission assembly 22 also includes a fixed shaft fixedly connected to the base plate 10. The multiple transmission wheels are rotatably connected to the fixed shaft. Specifically, there are three fixed shafts: a first fixed shaft 225 is spaced apart from the second fixed shaft 226 along the first direction, and a third fixed shaft 227 is spaced apart from the second fixed shaft 226 along the second direction. A first transmission wheel 2211 is rotatably mounted on the first fixed shaft 225, a second transmission wheel 2212 and a third transmission wheel 2221 are rotatably mounted on the second fixed shaft 226, and a fourth transmission wheel 2222 is rotatably mounted on the third fixed shaft 227, thereby enabling the rotation of multiple transmission wheels.

[0074] Optionally, the first, second, and third fixed shafts 225, 226, and 227 are each provided with a step to separate the base plate 10 from the transmission wheel, thereby reducing friction between the transmission wheel and the base plate 10. Optionally, one end of the first and second fixed shafts 225 and 226 are each provided with a threaded post for connecting to the base plate 10, and the other end is provided with a threaded groove for connecting to the transmission wheel and the toggle assembly 223. Optionally, both ends of the third fixed shaft 227 are provided with a threaded post for securing the base plate 10 to the fourth transmission wheel 2222, respectively.

[0075] Furthermore, if Figure 3 As shown, the toggle assembly 223 includes a first toggle rod 2231 and a second toggle rod 2232. The first toggle rod 2231 is fixedly connected to the first transmission wheel 2211. The first toggle rod 2231 can collide with the collision mechanism 30 during its movement, so that the baffle 21 is exposed to the opening 11. The second toggle rod 2232 is fixedly connected to the second transmission wheel 2212. The second toggle rod 2232 can collide with the collision mechanism 30 during its movement, so that the baffle 21 covers the opening 11. Optionally, as Figure 7 As shown, the first lever 2231 and the second lever 2232 are both provided with a first countersunk hole 22331. The bolt passes through the first countersunk hole 22331 and the corresponding first through hole 228 and is fixed by a nut, thereby respectively realizing a fixed connection between the first lever 2231 and the first transmission wheel 2211, and the second lever 2232 and the second transmission wheel 2212.

[0076] Alternatively, as Figures 8 to 12 As shown, the first lever 2231 and the second lever 2232 are set at a preset angle so that when the sample needle 210 is taken out of the suction head, the sample needle mechanism 200 drives the sample needle 210 and the suction head to move toward the sampling location, and the collision mechanism 30 moves with the sample needle 210 and collides with the second lever 2232, driving the second lever 2232 to rotate counterclockwise, so that the baffle 21 set on the second synchronous belt 2223 slides to the top of the opening 11 to block the opening 11; and the second lever 2232 rotates to outside the movement range of the collision mechanism 30, and the first lever 2231 rotates to the collision mechanism 30 at the same time. The collision mechanism 30 is within the movement range of the collision mechanism 30; after the sample needle 210 takes a sample, the sample needle mechanism 200 drives the sample needle 210 and the suction head to move toward the sample addition position, and the collision mechanism 30 moves with the sample needle 210 and collides with the first lever 2231, driving the first lever 2231 to rotate clockwise, so that the baffle 21 set on the second synchronous belt 2223 slides out from above the opening 11, exposing the opening 11; and the first lever 2231 rotates to outside the movement range of the collision mechanism 30, and the second lever 2232 rotates to within the movement range of the collision mechanism 30 at the same time; thereby, the opening 11 can be exposed or covered.

[0077] Preferably, the first lever 2231 and the second lever 2232 are respectively perpendicular to the positions when colliding with the collision mechanism 30 and the movement trajectory of the collision mechanism 30, so that the first lever 2231 and the second lever 2232 can rotate within the maximum range, driving the transmission wheel connected to the first lever 2231 and the second lever 2232 to rotate within the maximum range, so that the range of movement of the baffle 21 is larger and the sliding stroke of the baffle 21 is maximized, thereby reducing the diameter of the transmission wheel and the length of the synchronous belt, thereby saving the space occupied by the suction head protection device and improving space utilization.

[0078] Alternatively, as Figure 7 As shown, the first and second levers 2231 and 2232 have the same structure, each comprising a main body 2233 and a toggle portion 2234. The toggle portion 2234 is disposed at one end of the main body 2233, which is rotatably mounted on a fixed shaft. The first and second transmission wheels 2211 and 2212 are fixedly connected to the main bodies 2233 of the first and second levers 2231 and 2232, respectively. The range of motion of the toggle portion 2234 partially overlaps the range of motion of the collision mechanism 30, such that when the toggle portion 2234 is within the range of motion of the collision mechanism 30, it can collide with the collision mechanism 30, driving the main body 2233 to rotate, thereby driving the first and second transmission wheels 2211 and 2212 to rotate, thereby achieving transmission of the transmission assembly 22, causing the baffle 21 to cover or expose the opening 11. Optionally, a boss 22332 is provided at the bottom of the main body 2233 to better fit the first and second transmission wheels 2211 and 2212. Optionally, the first countersunk hole 22331 is opened on the main body 2233 .

[0079] In this embodiment, if Figure 3 As shown, the switch mechanism 20 further includes a limit assembly 25, which is fixed to the bottom plate 10 and located on one side of the toggle assembly 223. The limit assembly 25 can limit the toggle assembly 223. Optionally, as Figure 2 As shown, one of the limiting assembly 25 and the toggle assembly 223 is provided with a limiting groove 26, and the other is provided with a limiting protrusion 27. The limiting protrusion 27 can engage with the limiting groove 26 to achieve the limiting and fixed position of the toggle assembly 223. This structure can ensure that the rotation range of the first toggle lever 2231 and the second toggle lever 2232 is less than or equal to 90 degrees, preventing the first toggle lever 2231 and the second toggle lever 2232 from rotating too much, thereby preventing them from being unable to rotate back into the range of motion of the collision mechanism 30. This further prevents the tip protection device from losing its protective function during operation of the chemiluminescence immunoassay, thereby extending the service life of the product.

[0080] Optionally, in this embodiment, the limiting protrusion 27 is a bumper, and one of the toggle assembly 223 and the limiting assembly 25 is provided with a slot, and the limiting protrusion 27 can be rotatably disposed in the slot, thereby reducing the collision and friction between the toggle assembly 223 and the limiting assembly 25, and avoiding damage to the toggle assembly 223 and the limiting assembly 25. Optionally, the limiting assembly 25 further includes a fixing seat, which is fixedly connected to the base plate 10, and one of the limiting groove 26 or the limiting protrusion 27 is provided on the fixing seat, so that the limiting assembly 25 can be stably fixed to the base plate 10.

[0081] Specifically, in this embodiment, the toggle assembly 223 is provided with a limiting groove 26, specifically, a limiting groove 26 on the main body 2233. A limiting protrusion 27 is rotatably mounted on a fixed seat. Positioning the limiting protrusion 27 on the fixed seat reduces the weight of the toggle assembly 223, enabling better rotation. Optionally, two limiting assemblies 25 are provided, one on one side of the first toggle lever 2231 and one on one side of the second toggle lever 2232, respectively, to limit the first toggle lever 2231 and the second toggle lever 2232, so that the toggle portion 2234 has a rotation range of less than or equal to 90°. This ensures that when the collision mechanism 30 impacts and rotates one of the first toggle lever 2231 and the second toggle lever 2232, the other can rotate back to a position perpendicular to the motion trajectory of the collision mechanism 30.

[0082] In this embodiment, if Figure 2 As shown, the collision mechanism 30 includes a rolling member 31 configured to collide with the switch mechanism 20, reducing friction when the rolling member 31 collides with the switch mechanism 20 and thereby increasing the service life of the tip protection device. Optionally, the collision mechanism 30 also includes a connecting member 32, on which the rolling member 31 is disposed. The connecting member 32 is connected to the sample needle mechanism 200, enabling the rolling member 31 to move with the movement of the sample needle 210. Optionally, the rolling member 31 includes a bearing and a shaft, one end of the shaft being fixedly connected to the connecting member 32 and the other end being connected to the bearing. The bearing is configured to collide with the first and second levers 2231 and 2232, extending the service life of the bearing. The collision effect of the bearing can further reduce friction when the rolling member 31 collides with the first and second levers 2231 and 2232, thereby increasing the service life of the tip protection device and reducing maintenance requirements.

[0083] In this embodiment, if Figure 6As shown, the base plate 10 is further provided with a first fixing hole 12, so that the nozzle protection device can be fixedly installed above the nozzle storage device via bolts. This has a simple structure and can be fixed above the nozzle storage device without changing other structures. Optionally, the base plate 10 is further provided with a second fixing hole 13, through which the second fixing shaft 226 passes and is fixedly connected to the nut. Optionally, the base plate 10 has oblong holes 14 respectively formed in the first and second directions, and the first fixing shaft 225 and the third fixing shaft 227 pass through the oblong holes 14 formed in the first and second directions and are fixedly connected to the nut. The provision of the oblong holes 14 enables the distance between the first transmission wheel 2211 and the second transmission wheel 2212, as well as the distance between the third transmission wheel 2221 and the fourth transmission wheel 2222, to be adjusted. In addition, the tension of the first synchronous belt 2213 and the second synchronous belt 2223 can be adjusted, so that the transmission assembly 22 can transmit better.

[0084] It is understood that in other embodiments, the transmission assembly 22 may include only one set of synchronous pulley assemblies. By adjusting the angles of the first and second levers 2231, 2232, the position of the baffle 21, the position of the collision mechanism 30, and the length of the synchronous belt, the baffle 21 can be made to block or expose the opening 11 using only one set of synchronous pulley assemblies. However, if only one set of synchronous pulley assemblies is provided along the first direction, the space occupied by the pipette tip protection device in the first direction will need to be increased. If only one set of synchronous pulley assemblies is provided along the second direction, the shape of the collision mechanism 30 and the connection method of the sample needle mechanism 200 must be taken into consideration, and the angles of the first and second levers 2231, 2232, as well as the size of the transmission pulleys, will need to be readjusted, which will increase the space occupied.

[0085] Obviously, the above embodiments of the present invention are merely examples for the purpose of clearly illustrating the present invention and are not intended to limit the embodiments of the present invention. A person skilled in the art would be able to make various obvious changes, readjustments, and substitutions without departing from the scope of protection of the present invention. It is not necessary and impossible to enumerate all embodiments here. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention shall be included within the scope of protection of the claims of the present invention.

Claims

1. A chemiluminescence immunoassay analyzer, characterized in that: It comprises a sample needle mechanism (200), a pipette tip storage device and a pipette tip protection device, and is characterized in that the pipette tip protection device is arranged above the pipette tip storage device; The suction head protection device comprises: A bottom plate (10), wherein an opening (11) is formed on the bottom plate (10), and the opening (11) faces the suction tip storage device; a switch mechanism (20) disposed on the bottom plate (10), the switch mechanism (20) being configured to cover or expose the opening (11); and a collision mechanism (30) movably positioned above the bottom plate (10), the collision mechanism (30) being configured to collide with the switch mechanism (20) to drive the switch mechanism (20) to cover or expose the opening (11); The collision mechanism (30) of the pipette tip protection device is fixedly connected to the sample needle mechanism (200), and the collision mechanism (30) can move along with the movement of the sample needle mechanism (200); The switch mechanism (20) comprises: a baffle (21) slidably disposed on the bottom plate (10); and A transmission assembly (22) is provided on the bottom plate (10), the baffle (21) is fixedly connected to the transmission assembly (22), and the transmission assembly (22) is configured to drive the baffle (21) to perform reciprocating linear motion to cover or expose the opening (11); The transmission assembly (22) comprises: A first synchronous pulley assembly (221) is arranged on the base plate (10) along a first direction; a second synchronous pulley assembly (222) disposed on the base plate (10) along a second direction, the second direction being perpendicular to the first direction; a first end of the second synchronous pulley assembly (222) being transmission-connected to a second end of the first synchronous pulley assembly (221), and the baffle (21) being fixedly connected to the second synchronous pulley assembly (222); and a toggle assembly (223) disposed on the first synchronous pulley assembly (221), the toggle assembly (223) being configured to collide with the collision mechanism (30) to drive the first synchronous pulley assembly (221) and the second synchronous pulley assembly (222) to drive the baffle (21) to cover or expose the opening (11); The switch mechanism (20) further comprises a slider (23) and a slide rail (24); one of the baffle (21) and the base plate (10) is provided with the slider (23), and the other is provided with the slide rail (24); the slide rail (24) is slidably connected to the slider (23).

2. The chemiluminescence immunoassay analyzer according to claim 1, characterized in that The first synchronous pulley assembly (221) comprises a first transmission wheel (2211) and a second transmission wheel (2212) arranged at an interval, and a first synchronous belt (2213) wound around the first transmission wheel (2211) and the second transmission wheel (2212), and the first synchronous belt (2213) is tensioned by the first transmission wheel (2211) and the second transmission wheel (2212); The second synchronous pulley assembly (222) comprises a third transmission wheel (2221) and a fourth transmission wheel (2222) arranged at an interval, and a second synchronous belt (2223) wound around the third transmission wheel (2221) and the fourth transmission wheel (2222), and the second synchronous belt (2223) is tensioned by the third transmission wheel (2221) and the fourth transmission wheel (2222), the third transmission wheel (2221) and the second transmission wheel (2212) are coaxial and fixedly arranged, and the baffle (21) is fixedly connected to the second synchronous belt (2223).

3. The chemiluminescence immunoassay analyzer according to claim 2, characterized in that The toggle assembly (223) comprises: a first shifting rod (2231) fixedly connected to the first transmission wheel (2211); the first shifting rod (2231) is configured to collide with the collision mechanism (30) to allow the baffle (21) to expose the opening (11); and A second shifting rod (2232) is fixedly connected to the second transmission wheel (2212); the second shifting rod (2232) is configured to collide with the collision mechanism (30) so that the baffle (21) blocks the opening (11).

4. The chemiluminescence immunoassay analyzer according to claim 1, characterized in that The switch mechanism (20) further comprises a limiting assembly (25), the limiting assembly (25) being fixedly connected to the base plate (10) and located on one side of the toggle assembly (223), the limiting assembly (25) being configured to limit the toggle assembly (223).

5. The chemiluminescence immunoassay analyzer according to claim 4, characterized in that: One of the limiting assembly (25) and the shifting assembly (223) is provided with a limiting groove (26), and the other is provided with a limiting protrusion (27), and the limiting protrusion (27) can be engaged with the limiting groove (26).

6. The chemiluminescence immunoassay analyzer according to any one of claims 1 to 5, characterized in that: The collision mechanism (30) comprises a rolling member (31), and the rolling member (31) is used to collide with the switch mechanism (20).

Images