A multi-item body fluid analyzer

Abstract

The invention discloses a multi-item body fluid analyzer, including a base, a test tube rack loading module is provided on the top of the base, a plurality of test tubes are installed side by side inside the test tube rack, the test tube rack is movably installed to the test tube rack loading module, a test tube rack conveying module is provided beside the test tube rack module, the test tube rack loading module drives the test tube rack to move, and pushes it to be installed to the test tube rack conveying module, a test strip dispensing module and a cell centrifugal concentration module are provided on the top of the base, the test tube rack conveying module drives the test tubes in the test tube rack to correspond to the test strips in the test strip dispensing module, the test strip detection module is located above the test strip dispensing module, a cell morphology scanning module is provided on the outside of the cell centrifugal concentration module, and a grabbing and transferring module grabs the test tube rack on the test tube rack conveying module to the cell centrifugal concentration module and the cell morphology scanning module in sequence. The instrument has a simple structure, adopts a liquid-free pipeline design, and can realize full-automatic detection of multiple specimens and multiple items in one.

Description

Technical Field

[0001] The present invention relates to the technical field of medical analysis instruments, and in particular to a multi-item body fluid analyzer. Background Art

[0002] The analytical instruments and main workflows currently used in urine, gynecological secretions (leucorrhea), and stool testing on the market are as follows:

[0003] Urine fully automatic production line (consisting of two machines: a fully automatic urine dry chemical analyzer and a urine sediment cell morphology analyzer): Urine dry chemical test strips use the reflectivity principle and use diodes or image sensors as detection receiving devices. Urine sediment cell morphology uses microscope cell image recognition or flow cytometry principles. The main workflows of the samples of the above two machines are: loading the test tube rack, aspirating needles, transporting silicone pipes, cleaning pipes, disinfecting pipes, etc. The chemical analyzer includes: test strip material selection and feeding components, needle pipette liquid droplet sampling components, and optical probe scanning components; the urine sediment cell morphology analyzer includes: liquid is sucked into the counting pool by a pump, microscope scanning or flow cytometer scanning, etc.

[0004] Gynecological secretion analysis system (consisting of vaginitis automatic detection workstation (vaginitis joint test paper card), microscopic cell analyzer, etc.). Its analysis method is similar to urine, but the specimen processing method is different. Cotton fiber balls are used for sampling, the cotton ball samples are diluted and washed, and then coated on glass slides. The test paper is a gold-labeled card with a plastic plate. Other operation steps such as needle aspiration, cleaning and liquid pipelines are the same.

[0005] The specimen processing method of the fully automatic stool analyzer is somewhat similar to that of leucorrhea. Samples are taken with a small spoon, filtered and stored in a special stool cup net, stirred and mixed by a motor, and then photographed using a flowing counting cell or disposable counting plate.

[0006] The above analytical instruments all have the following defects when used:

[0007] (1) They all use a large number of complex liquid pipelines and liquid controllers, and there are problems such as cross contamination, pipeline blockage, repeated flushing after each addition, high cost, and easy errors;

[0008] Urine sediment cells, leucorrhea, and stool are all highly viscous samples, which are very easy to clog pipes and counting cells, and are prone to cross contamination. When cleaning and disinfecting pipes and equipment, a large amount of waste liquid and reagent consumption are easily generated, and the processing process is time-consuming. In particular, urine sediment requires centrifugation to remove the supernatant, which is difficult to achieve with existing automated instruments for stratified sediment extraction. At the same time, due to the high viscosity of the sediment, the sample aspiration needle is particularly difficult to absorb, and it is also difficult to transport it to the flow counting cell through a silicone tube. In addition, urine sediment centrifugation is too difficult to achieve the effect of cell centrifugation concentration, and because concentrated cells are not taken, the detection positivity rate is low, it is easy to miss detection, and scanning images is numerous and time-consuming.

[0009] (2) The above-mentioned instrument uses each person's specimen as a processing unit and processes each specimen in a cycle, which is time-consuming and labor-intensive, and the specimen processing and detection speed is slow. In addition, the instrument structure is complex.

[0010] (3) Samples such as urine, gynecological secretions, and stool are all handled by independent instruments, which makes it impossible to share resources between instruments, increasing development, production, after-sales maintenance, and management costs.

[0011] (4) The test strips are packaged in a drum, which is prone to sticking and falling off, and the failure rate of reversed strips is high. Summary of the invention

[0012] In order to solve the problems existing in the above-mentioned background technology, the present invention provides a multi-item body fluid analyzer, which uses a test tube rack as an operating unit and adopts a liquid-free pipeline design. It only needs to move the test tube rack to each detection module to realize full-automatic detection of multiple specimens and multiple items in one, which greatly saves detection time, improves detection speed and detection accuracy, reduces the complexity of the instrument, and the instrument operates stably and reliably.

[0013] In order to achieve the above object, the present invention adopts the following technical solutions:

[0014] The present invention provides a multi-item body fluid analyzer, including a base, a test tube, a test tube rack, a test tube rack loading module, a test tube rack conveying module, a test strip packaging module, a test strip detection module, a cell centrifugation concentration module, a cell morphology scanning module and a grabbing and transferring module;

[0015] A plurality of test tubes are installed side by side inside the test tube rack.

[0016] A test tube rack loading module is provided on the top of the base, the test tube rack is movably mounted on the test tube rack loading module, a test tube rack conveying module is provided beside the test tube rack module, the test tube rack loading module drives the test tube rack to move, and pushes the test tube rack to be installed on the test tube rack conveying module.

[0017] A test strip dispensing module and a cell centrifugation concentration module are provided on the top of the base along the conveying direction of the test tube rack conveying module.

[0018] The test tube rack conveying module drives the test tube rack to move and rotate, and controls the test tubes in the test tube rack to correspond to the test strips in the test strip dispensing module.

[0019] The test strip detection module is located on the base and above the test strip packaging module.

[0020] The cell morphology scanning module is arranged outside the cell centrifugal concentration module.

[0021] The grabbing and transferring module grabs the test tube rack on the test tube rack conveying module and sequentially moves it to the cell centrifugation concentration module and the cell morphology scanning module.

[0022] A further improvement is that the test tube comprises a tube body, which is open at both ends and has a hollow structure inside. A cover plug is slidably sealed installed at the opening of one end of the tube body, and a drain pipe is provided at the opening of the other end of the tube body. The end of the drain pipe is covered with a drain cap plug, and a liquid blocking plug is provided inside the drain cap plug. The liquid blocking plug is in movably sealed contact with the end of the drain pipe, and a drainage hole is provided on the side of the drain cap plug. The side of the tube body away from the end of the cover plug opens to form a liquid guide groove, and a cover body with a transparent structure is movably sealed installed at the liquid guide groove. An automatic separation component for separating and covering the drain tube and the liquid blocking plug in the drain cap plug is provided on the base.

[0023] A further improvement is that a liquid blocking member is provided at the connection between the liquid guide groove and the tube body, and a liquid flow channel for connecting the inside of the tube body and the liquid guide groove is opened inside the liquid blocking member, and the height of the liquid flow channel close to the liquid guide groove is lower than the height close to the tube body.

[0024] A further improvement is that the liquid blocking member is provided with a filter mesh slot near one end of the liquid guiding groove, and a filter mesh is inserted into the filter mesh slot.

[0025] A further improvement is that the automatic separation component is fixedly mounted on the test strip detection module through a fixing seat, and the automatic separation component is located between the test tube rack conveying module and the test strip packaging module, the automatic separation component comprises a U-shaped mounting member, a telescopic driving member, a sliding member, a connecting member, a first fixed plate, a pulling claw and a tightening column, the U-shaped mounting member is fixedly mounted on the bottom of the fixing seat, the sliding member is slidably mounted inside the U-shaped mounting member, the end of the telescopic driving member is connected to one end of the sliding member, driving the sliding member to move back and forth inside the U-shaped mounting member, the first fixed plate is connected to the sliding member through a connecting member, a plurality of tightening columns and pulling claws are installed on the first fixed plate, the tightening column and the pulling claw are staggered front and back, the end of the tightening column can be movably extended into the interior of the test tube rack and contact with the free end of the drainage cap plug on the corresponding test tube, a plurality of plug-in slots are formed inside the pulling claw, and the drainage cap plug on the test tube can be movably inserted into the plug-in slot.

[0026] A further improvement is that the test tube rack conveying module includes a first linear moving component, a sliding plate, a mounting seat, a rotating motor, a rotating rod, a connecting frame, an oscillator, an electric heating constant temperature plate, a supporting plate and an elastic clamping fixing part, the first linear moving component is fixedly mounted on the top of the base, and the first linear moving component is connected to the sliding plate located above it, two mounting seats are symmetrically arranged on the top of the sliding plate, the rotating rod is rotatably connected between the two mounting seats, one end of the rotating rod is drivingly connected to the rotating motor, the connecting frame is fixedly mounted on the rotating rod, the top of the connecting frame is sequentially connected to an oscillator and an electric heating constant temperature plate, the top of the electric heating constant temperature plate is provided with a supporting plate for placing the test tube rack, the supporting plate is provided with an elastic clamping fixing part for clamping and fixing the outside of the test tube rack, the top of the supporting plate is also provided with a drainage push cylinder, the output end of the drainage push cylinder is connected to a second fixed plate, a plurality of drainage push rods are arranged side by side on the second fixed plate, and the end of the drainage push rod is in movably contact with the cover plug at the end of the test tube inside the test tube rack.

[0027] A further improvement is that the test strip packaging module includes a bottom plate, a fixed column, a table, a packaging robot, a second linear motion component, a mounting plate, a feeding plate, a test strip storage box and a test strip pushing cylinder, the bottom plate is located on the base, a plurality of the fixed columns are fixed on the top of the bottom plate, the table and the mounting plate are fixedly mounted on the fixed columns, a plurality of grooves for placing test strips are arranged side by side on the table, the second linear motion component is located on the bottom plate, and the second linear motion component is fixedly connected to the packaging robot located above it, the second linear motion component drives the packaging robot to move in a direction perpendicular to the length of the test strip in the groove, and the top of the packaging robot A bracket is provided at a position corresponding to the groove, and an opening is provided on the table for the dispensing robot to pass through; the feeding plate is movably placed on the top of the mounting plate, and a receiving groove for holding the test strip is provided on the top of the feeding plate, and the length direction of the receiving groove is consistent with the length direction of the groove on the table; a test strip storage box is installed on the mounting plate, and an opening is provided at the bottom of the test strip storage box corresponding to the receiving groove, and the end of the feeding plate is connected to the test strip pushing cylinder, and under the drive of the test strip pushing cylinder, the feeding plate moves toward or away from the table, and an opening is provided on the feeding plate at the receiving groove for the dispensing robot to pass through.

[0028] A further improvement is that a third linear motion component is provided on the top of the base, the third linear motion component is drivingly connected to the bottom plate, and the third linear motion component drives the bottom plate to move in a direction approaching or away from the test tube rack conveying module.

[0029] A further improvement is that the bottom of the base plate is hinged to the top of the base at one end away from the test tube rack conveying module, an electric push rod is hingedly installed inside the base, and the output end of the electric push rod passes through the base and is connected to the bottom of the base plate.

[0030] A further improvement is that the cell centrifugal concentration module comprises a centrifugal container, the bottom of the centrifugal container is mounted on the base, a tray for fixing the test tube rack is provided inside the centrifugal container, a protective cover is provided on the movable cover at the top opening of the centrifugal container, a centrifugal motor is provided at the bottom of the centrifugal container, and a driving end of the centrifugal motor passes through the centrifugal container and is connected to the bottom of the tray;

[0031] The cell morphology scanning module includes a workbench, a bracket is provided under the workbench, an X-axis moving module is provided on the top of the bracket, the X-axis moving module is connected to the bottom of the workbench, a Y-axis moving module is provided on the top of the workbench, a test tube rack fixing plate is connected to the Y-axis moving module, a limit piece for fixing the test tube rack is provided on the top of the test tube rack fixing plate, a high-power objective lens and a low-power objective lens are provided above the workbench, a third fixed plate arranged vertically is provided on the side of the workbench, a Z-axis moving module is provided on the third fixed plate, and the outer sides of the high-power objective lens and the low-power objective lens are connected to the Z-axis moving module through a connecting seat.

[0032] Compared with the prior art, the present invention has the following beneficial effects:

[0033] 1. The instrument adopts liquid-free pipelines, with simple structure and few faults. Existing instruments on the market all use complex liquid pipelines composed of suction needles for sample suction, silicone pipelines for sample delivery, sample dropping, counting pool sample filling, flushing pipelines, disinfection pipelines, solenoid valve control, peristaltic pumps, etc. The pipeline control is complex, easy to block holes, easy to cross-contaminate, and high fault rate. The absence of liquid pipelines is the most prominent advantage of this instrument;

[0034] 2. The instrument uses multiple test tube samples on the test tube rack as the operation unit, and processes and tests multiple specimens at one time. All the test items can be completed by moving the test tube rack to each test module, which greatly saves the test time and reduces the complexity of the instrument. The existing instruments on the market use each person's specimen as the processing unit;

[0035] 3. The instrument's detection modules are shared by various specimens, which simplifies the instrument, saves a lot of costs, and realizes multi-sample and multi-item detection in one: including urine, leucorrhea, stool and other body fluid samples; multiple chemical test strips and microscope cell morphology multi-item detection;

[0036] 4. The instrument simplifies the complex: the instrument is simplified in terms of structure and principle, and the work that can only be completed by more than a dozen instruments of other companies in the market is simplified to one machine. The instrument has a simple structure and low cost, and the instrument is more stable and reliable with a very low failure rate;

[0037] 5. Detection technology: The test strip detection module innovatively adopts a mode combining CCD camera, large area light source and computer image analysis software, which can detect multiple test strips and multiple samples at the same time. Compared with the diode, image sensor and microcomputer chip as detection devices on the market, the analysis accuracy is greatly improved and the detection speed is increased by dozens of times;

[0038] 6. The test tube structure of the instrument has been improved, and all processes from sample collection, loading, mixing, filtration, centrifugation, drainage, and microscopic examination are completed in a sealed test tube cavity;

[0039] 7. The cell morphology scanning module uses a large stage and a fixed dual-objective automatic microscope. The stage can hold a test tube rack with 5-10 test tubes. There is no need to switch between high and low magnification objective lenses, and the dual lenses work simultaneously.

[0040] 8. The test strip dispensing module innovatively adopts box-type magazine flat push loading during the test strip loading process, avoiding the time-consuming material retrieval, test strip crooked, reversed, stuck, and dropped problems that occur in the drum-type loading on the market;

[0041] 9. The cell centrifugal concentration module adopts a unique rack centrifugation. It does not need to insert test tubes one by one into the centrifugal container. Instead, the test tube rack with multiple test tubes is automatically placed into the centrifugal container at one time through the grabbing and transferring module;

[0042] 10. Full automation: All items of all specimens are fully automated. The operator only needs to put the test tube containing the sample liquid into the test tube rack, install the test tube rack to the test tube rack loading module, and load the test strip storage box containing 50-100 chemical test strips into the test strip packaging module. The rest is completed by the instrument fully automatically: automatic loading, mixing, dripping, constant temperature, test strip detection, centrifugation, microscope cell morphology detection, and waste disposal, realizing unmanned full automation.

[0043] 11. The instrument is a fully automatic instrument, which is suitable for both large tertiary hospitals and small hospitals. Urine, leucorrhea and stool are three routine items in hospitals, so the demand is particularly large. In addition, the instrument has a simple structure, and each specimen module is shared, so the production cost is extremely low. The instrument is stable, has few faults, and has a fast detection speed, so it has broad market prospects. BRIEF DESCRIPTION OF THE DRAWINGS

[0044] The present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0045] Figure 1 It is a schematic diagram of the overall structure of the multi-item body fluid analyzer of the present invention;

[0046] Figure 2 It is a structural schematic diagram of the test tube in the present invention;

[0047] Figure 3 Schematic diagram of the split structure of the test tube in the present invention;

[0048] Figure 4 It is a structural schematic diagram of the test tube and the test tube rack in the present invention when they are installed in coordination;

[0049] Figure 5 It is a structural schematic diagram of the test tube rack loading module in the present invention;

[0050] Figure 6 It is a structural schematic diagram of the test tube rack conveying module in the present invention;

[0051] Figure 7 It is a schematic diagram of the local structure of the sliding plate in the present invention;

[0052] Figure 8 This is a schematic diagram of the structure of the test strip packaging module in the present invention;

[0053] Fig. 9 It is a schematic diagram of the local structure of the feeding plate in the present invention;

[0054] Fig.10 It is a schematic diagram of the local structure of the test strip detection module in the present invention;

[0055] Fig.11 It is a structural schematic diagram of the automatic separation component in the present invention;

[0056] Fig.12 It is a schematic diagram of the structure of the cell centrifugal concentration module in the present invention;

[0057] Fig.13 for Figure 1 The enlarged structure diagram at A in the middle;

[0058] Among them, the specific figures are marked as: base 1, waste outlet 2, test tube 3, tube body 301, cover plug 302, connecting column 303, sampler 304, liquid guide groove 305, cover body 306, liquid blocking member 307, filter screen slot 308, filter screen 309, drain pipe 310, positioning boss 311, drain cap plug 312, drain hole 313, test tube rack 4, test tube rack loading module 5, linear drive assembly 501, rack 502, guide rail 503, loading guide groove 504, test tube rack pusher 5 05, test tube rack conveying module 6, first linear moving component 601, sliding plate 602, mounting seat 603, rotating motor 604, rotating rod 605, connecting frame 606, oscillator 607, electric heating constant temperature plate 608, supporting plate 609, elastic clamping fixing part 610, liquid discharge pushing cylinder 611, second fixing plate 612, liquid discharge pushing rod 613, test strip dispensing module 7, bottom plate 701, fixing column 702, table 703, groove 704, dispensing robot 705, bracket 70 6, second linear motion component 707, mounting plate 708, guide bar 709, feeding plate 710, accommodating groove 711, test strip storage box 712, test strip pushing cylinder 713, third linear motion component 714, test strip detection module 8, support frame 801, CCD detection device 802, automatic separation component 9, fixed seat 901, U-shaped mounting member 902, telescopic driving member 903, sliding member 904, connecting member 905, first fixing plate 906, pulling claw 907, top tightening Column 908, cell centrifugation concentration module 10, centrifuge container 1001, tray 1002, protective cover 1003, slide rail 1004, protective cover push cylinder 1005, cell morphology scanning module 11, workbench 1101, bracket 1102, X-axis moving module 1103, Y-axis moving module 1104, test tube rack fixing plate 1105, high-power objective lens 1106, low-power objective lens 1107, third fixed plate 1108, Z-axis moving module 1109, grabbing and transferring module 12. DETAILED DESCRIPTION

[0059] The embodiment of the present invention discloses a multi-item body fluid analyzer, such as Figure 1 and Figure 4 As shown, it includes a base 1, a test tube 3, a test tube rack 4, a test tube rack loading module 5, a test tube rack conveying module 6, a test strip packaging module 7, a test strip detection module 8, a cell centrifugation concentration module 10, a cell morphology scanning module 11 and a grabbing and transferring module 12;

[0060] A plurality of test tubes 3 are installed side by side inside the test tube rack 4, a test tube rack loading module 5 is provided on the top of the base 1, the test tube rack 4 is movably installed on the test tube rack loading module 5, a test tube rack conveying module 6 is provided on the side of the test tube rack 4 module, the test tube rack loading module 5 drives the test tube rack 4 to move, and pushes the test tube rack 4 to be installed on the test tube rack conveying module 6, a test strip dispensing module 7 and a cell centrifuge concentration module 10 are provided on the top of the base 1 along the conveying direction of the test tube rack conveying module 6, the test tube rack conveying module 6 drives the test tube rack 4 to move and rotate, and controls the test tubes 3 in the test tube rack 4 to correspond to the test strips in the test strip dispensing module 7, the test strip detection module 8 is located on the base 1, and is located above the test strip dispensing module 7, a cell morphology scanning module 11 is provided on the outside of the cell centrifuge concentration module 10, and the grabbing and transferring module 12 grabs the test tube rack 4 on the test tube rack conveying module 6 to the cell centrifuge concentration module 10 and the cell morphology scanning module 11 in sequence.

[0061] Among them, Figure 2 and Figure 3 As shown, the test tube 3 includes a tube body 301, which is open at both ends and has a hollow structure inside. A cover plug 302 is installed at the opening of one end of the tube body 301 in a sliding and sealing manner. The cover plug 302 is connected to a sampler 304 through a connecting column 303 (the sampler 304 can be a spoon, a cotton swab or a handle-shaped structure). A drainage tube 310 is provided at the opening of the other end of the tube body 301. A plurality of positioning bosses 311 are provided on the outside of the drainage tube 310. A drainage cap 312 is provided at the end of the drainage tube 310. A liquid blocking plug (not shown in the figure) is provided inside the drainage cap 312. The liquid blocking plug is a protruding conical structure. The liquid blocking plug is movably connected to the end of the drainage tube 310. The dynamic sealing contact serves to prevent the liquid in the drain pipe 310 from being discharged from the drain hole 313. The drain hole 313 is provided on the side of the drain cap 312. When the drain cap 312 is covered on the drain pipe 310, the drain hole 313 can be conveniently positioned by the positioning boss 311, ensuring that the drain hole 313 is vertically downward. The side opening of the tube body 301 away from the end of the cap 302 forms a liquid guide groove 305, and a transparent cover body 306 is installed at the liquid guide groove 305. An automatic separation component 9 for separating and covering the drain pipe 310 and the liquid blocking plug in the drain cap 312 is provided on the base 1. Specifically, a liquid blocking member 307 is provided at the connection between the liquid inlet groove 305 and the tube body 301, and a liquid flow channel for connecting the inside of the tube body 301 and the liquid inlet groove 305 is provided inside the liquid blocking member 307, and the height of the liquid flow channel near the liquid inlet groove 305 is lower than the height near the tube body 301. A filter mesh slot 308 is provided at one end of the liquid blocking member 307 near the liquid inlet groove 305, and a filter mesh 309 is inserted into the filter mesh slot 308.

[0062] Specifically, Fig.11As shown, the automatic separation component 9 is fixedly mounted on the test strip detection module 8 through a fixing seat 901, and the automatic separation component 9 is located between the test tube rack conveying module 6 and the test strip packaging module 7. The automatic separation component 9 includes a U-shaped mounting member 902, a telescopic driving member 903, a sliding member 904, a connecting member 905, a first fixing plate 906, a pulling claw 907 and a tightening column 908. The U-shaped mounting member 902 is fixedly mounted on the bottom of the fixing seat 901, and the sliding member 904 is slidably mounted inside the U-shaped mounting member 902. The end of the telescopic driving member 903 is connected to the sliding member 904. One end is connected, driving the sliding member 904 to move forward and backward inside the U-shaped mounting member 902, and the first fixed plate 906 is connected to the sliding member 904 through the connecting member 905. A plurality of tightening columns 908 and pulling claws 907 are installed on the first fixed plate 906, and the tightening columns 908 and pulling claws 907 are staggered left and right. The end of the tightening column 908 can be movably extended into the test tube rack 4 and contact with the free end of the drainage cap 312 on the corresponding test tube 3, and a plurality of plug-in grooves are formed inside the pulling claw 907, and the edges on both sides of the drainage cap 312 on the test tube 3 can be movably inserted into the plug-in grooves.

[0063] Among them, Figure 5 As shown, the test tube rack loading module 5 includes a linear drive component 501, a material rack 502, a guide rail 503, a loading guide groove 504, a slider and a test tube rack pusher 505. The material rack 502 is fixed on the base 1, and guide rails 503 are provided on opposite sides of the material rack 502 along the length direction. A loading guide groove 504 is opened on the top of the guide rail 503, and the test tube rack pusher 505 is slidably connected to the guide rails 503 respectively. The test tube rack 4 is movably placed on the guide rails 503, and the bottom end of the test tube rack 4 is slidably connected to the loading guide groove 504, and the bottom end of the test tube rack pusher 505 is connected to the linear drive component 501.

[0064] Among them, Figure 6 and Figure 7As shown, the test tube rack conveying module 6 includes a first linear moving component 601, a sliding plate 602, a mounting seat 603, a rotating motor 604, a rotating rod 605, a connecting frame 606, an oscillator 607, an electric heating constant temperature plate 608, a supporting plate 609 and an elastic clamping fixing member 610. The first linear moving component 601 is fixedly installed on the top of the base 1, and the first linear moving component 601 is connected to the sliding plate 602 located above it. The top of the sliding plate 602 is symmetrically provided with two mounting brackets. The mounting seat 603, a rotating rod 605 is rotatably connected between the two mounting seats 603, one end of the rotating rod 605 is connected to the rotating motor 604, a connecting frame 606 is fixedly installed on the rotating rod 605, the top of the connecting frame 606 is connected to the oscillator 607 and the electric constant temperature plate 608 in sequence, the top of the electric constant temperature plate 608 is provided with a supporting plate 609 for placing the test tube rack 4, and the supporting plate 609 is provided with an elastic clamping fixture 610 for clamping and fixing the outer side of the test tube rack 4. A liquid discharge push cylinder 611 is also provided at the top of the supporting plate 609, the output end of the liquid discharge push cylinder 611 is connected to the second fixed plate 612, and a plurality of liquid discharge push rods 613 are arranged side by side on the second fixed plate 612, and the ends of the liquid discharge push rods 613 are in active contact with the cover plug 302 at the end of the test tube 3 inside the test tube rack 4.

[0065] Among them, Figure 8 and Fig. 9As shown, the test strip packaging module 7 includes a bottom plate 701, a fixed column 702, a table 703, a packaging robot 705, a second linear moving component 707, a mounting plate 708, a feeding plate 710, a test strip storage box 712 and a test strip pushing cylinder 713. The bottom plate 701 is located on the base 1, and a plurality of fixed columns 702 are fixed on the top of the bottom plate 701. The table 703 and the mounting plate 708 are fixedly installed on the fixed columns 702, and the table 703 is provided with a plurality of fixed columns 702, and the fixing columns 702 are fixedly installed with the table 703 and the mounting plate 708. There are multiple grooves 704 for placing test strips, the second linear moving component 707 is located on the bottom plate 701, and the second linear moving component 707 is fixedly connected to the packaging robot 705 located above it, the second linear moving component 707 drives the packaging robot 705 to move in a direction perpendicular to the length of the test strip in the groove 704, a bracket 706 is provided at the top of the packaging robot 705 corresponding to the groove 704, and an opening is provided on the table 703 for the top of the packaging robot 705 to pass through; two guide strips 709 are symmetrically arranged on the top of the mounting plate 708, and the opposite sides of the feed plate 710 are slidably connected to the guide strips 709 respectively, and a receiving groove 711 for holding the test strip is provided on the top of the feed plate 710, the depth of the receiving groove 711 is the thickness of a test strip, and the length direction of the receiving groove 711 is consistent with the length direction of the groove 704 on the table 703, and the test strip storage box 712 is movably mounted on the top of the guide strip 709 The test strip storage box 712 is a disposable consumable. When the test strips inside are used up, they can be replaced. An opening is set at the bottom of the test strip storage box 712 corresponding to the accommodating groove 711, and the end of the feeding plate 710 is connected to the test strip pushing cylinder 713. Driven by the test strip pushing cylinder 713, the feeding plate 710 moves toward or away from the platform 703. An opening is set on the feeding plate 710 at the accommodating groove 711 for the top of the dispensing robot 705 to pass through.

[0066] In one of the embodiments, the linear movement of the test strip dispensing module 7 is realized, and a third linear moving component 714 is provided on the top of the base 1. The third linear moving component 714 is drivingly connected to the bottom plate 701, and the third linear moving component 714 drives the bottom plate 701 to move in a direction close to or away from the test tube rack conveying module 6.

[0067] In another specific embodiment, the test strip dispensing module 7 is flipped at a certain angle, and the bottom of the bottom plate 701 is hinged to the top of the base 1 at one end away from the test tube rack conveying module 6. An electric push rod is hingedly installed inside the base 1, and the output end of the electric push rod passes through the base 1 and is connected to the bottom of the bottom plate 701.

[0068] During specific use, the linear moving component and the flipping component can be installed at the same time, which can control the test strip dispensing module 7 to move linearly and also drive it to flip at a certain angle.

[0069] Among them, Fig.10 As shown, the test strip detection module 8 is a CCD detection device 802, which is fixedly mounted on the base 1 via a support frame 801. The CCD detection device 802 includes a top plate located on the top of the support frame, a large-area light source and a CCD camera are mounted at the bottom of the top plate, the CCD camera is electrically connected to the image analysis software in the external computer, and the automatic separation component 9 is mounted on the support frame 801.

[0070] Among them, Fig.12 As shown, the cell centrifugal concentration module 10 includes a centrifugal container 1001, the bottom of the centrifugal container 1001 is installed on the base 1, a tray 1002 for fixing the test tube rack 4 is provided inside the centrifugal container 1001, a centrifugal motor is provided at the bottom of the centrifugal container 1001, the driving end of the centrifugal motor passes through the centrifugal container 1001 and is connected to the bottom of the tray 1002, and a protective cover 1003 is provided at the movable cover at the top opening of the centrifugal container 1001. In this embodiment, slide rails 1004 are symmetrically provided at the top opening of the centrifugal container 1001, and the bottom of the protective cover 1003 is slidably connected to the slide rails 1004 through a slider, and a protective cover push cylinder 1005 is provided at the top of the centrifugal container 1001, and the output end of the protective cover push cylinder 1005 is connected to the top of the protective cover 1003

[0071] Among them, Fig.13 As shown, the cell morphology scanning module 11 includes a workbench 1101, a bracket 1102 is provided below the workbench 1101, an X-axis moving module 1103 is provided on the top of the bracket 1102, the X-axis moving module 1103 is connected to the bottom of the workbench 1101, a Y-axis moving module 1104 is provided on the top of the workbench 1101, a test tube rack fixing plate 1105 is connected to the Y-axis moving module 1104, a limiter for fixing the test tube rack 4 is provided on the top of the test tube rack fixing plate 1105, a high-power objective lens 1106 and a low-power objective lens 1107 are provided above the workbench 1101, a third fixed plate 1108 is vertically arranged beside the workbench 1101, a Z-axis moving module 1109 is provided on the third fixed plate 1108, and the outer sides of the high-power objective lens 1106 and the low-power objective lens 1107 are connected to the Z-axis moving module 1109 through a connecting seat. A waste outlet 2 is provided on the base 1 , and a waste disposal box is provided below the waste outlet 2 .

[0072] The grabbing and transferring module 12 may adopt an existing manipulator structure with a moving function.

[0073] The specific working steps are as follows:

[0074] 1. Draw materials

[0075] 1.1. The doctor or patient pours urine into the test tube 3 (forming a urine specimen);

[0076] 1.2. The patient takes a sample of leucorrhea secretions with the cover plug 302 with cotton fibers, and then inserts the cover plug 302 with cotton fibers into the opening at the end of the test tube 3, so that the leucorrhea sample on the cotton fibers is immersed in the diluent inside the test tube 3 (forming a leucorrhea specimen);

[0077] 1.3. The patient uses the cover plug 302 with the sampling spoon to take a stool sample, and then inserts the cover plug 302 into the mouth of the test tube 3, so that the stool sample on the sampling spoon is immersed in the diluent in the test tube 3 (forming a stool specimen).

[0078] 2. Loading

[0079] 2.1. The operator inserts the test tube 3 into the test tube rack 4. One test tube rack 4 can insert multiple test tubes 3. Then the test tube rack 4 is placed on the guide rail 503 in the test tube rack loading module 5.

[0080] 2.2. The test tube rack pusher 505 automatically pushes the test tube rack 4 forward, stops at the front end of the rack 502 and waits;

[0081] 2.3. After the first linear moving assembly 601 drives the upper part of the sliding plate 602 to move to the empty position of the instrument, the rotating motor 604 controls the rotating rod 605 to rotate until the support plate 609 forms a 90-degree angle with the base 1, and then the first linear moving assembly 601 drives the upper part of the sliding plate 602 to move until it is just aligned with the test tube rack 4 and stops;

[0082] 2.4 The test tube rack pusher 505 pushes the test tube rack 4 into the support plate 609, and the test tube rack 4 is clamped and fixed by the elastic clamping fixing member 610 on the support plate 609. The first linear moving component 601 drives the upper part of the sliding plate 602 to move to the empty position of the instrument and then rotates until the support plate 609 is parallel to the base 1. The first linear moving component 601 then drives the upper part of the sliding plate 602 to move forward to the test strip dispensing module 7 station;

[0083] 2.5 Use oscillator 607 to oscillate and mix the sample in test tube 3.

[0084] 3. Automatic dispensing of chemical test strips, automatic dripping of test tubes and CCD camera detection

[0085] 3.1. The bottom test strip in the test strip storage box 712 enters the receiving groove 711 on the feeding plate 710, and the test strip pushing cylinder 713 pushes the feeding plate 710 out. At this time, the test strip is taken out, and the second linear moving component 707 drives the dispensing robot 705 to the bottom of the feeding plate 710, and aligns the first bracket 706 on the dispensing robot 705 with the test strip in the receiving groove 711 on the feeding plate 710, and then the dispensing robot 705 rises to lift the test strip and then moves back to put the test strip into the first groove 704 on the table 703; the previous steps are repeated to push out another test strip from the test strip and put it into the first groove 704 on the table 703, and the test strip in the first groove 704 of the original table 703 is moved into the second groove 704 on the table 703, and the dispensing is done in sequence until the grooves 704 on the table 703 are filled with test strips;

[0086] 3.2. The first linear moving component 601 drives the upper part of the sliding plate 602 to move to the automatic separation component 9, and drives the test tube 3 in the test tube rack 4 on the support plate 609 to rotate slowly upward and backward through the rotating motor 604 until the test tube 3 is correspondingly plugged into the plug slot on the pull claw 907, and then the pull claw 907 is pulled backward by the telescopic driving member 903. At this time, the drain tube 310 is separated from the liquid blocking plug in the drain cap 312, and the drain hole 313 is in an open state. Then, the drain push rod 613 drives the cover plug 302 to squeeze into the tank body, and the sample liquid in the test tube 3 quickly drips out from the drain hole 313 on the drain cap 312. There are two ways to add the sample liquid to the test strip on the platform 703:

[0087] Mode 1: The support plate 609 is driven to be at right angles to the base 1 by the rotating motor 604, and the test strip dispensing module 7 is driven by the third linear moving component 714 to move one step at a time. A detection item block on the test strip on the dispensing module 7 moves to the bottom of the drainage port of each test tube 3 on the support plate 609, and the sample liquid in the test tube 3 drips out from the drainage hole 313 on the drainage cap plug 312 to the detection item block on each test strip. The above actions are repeated until all the detection item blocks on the test strip are dripped with the sample liquid, thereby realizing that multiple test tubes 3 drip sample liquid onto multiple test strips at the same time;

[0088] Method 2: lift one end of the test strip dispensing module 7 by an electric push rod and tilt it to about 45 degrees. At the same time, the rotating motor 604 drives the support plate 609 to rotate until the drainage hole 313 on the drainage cap plug 312 of each test tube 3 is aligned with the upward end of the test strip on the support plate 609, and the sample liquid slowly flows downward along one side of the test strip to each detection item block.

[0089] 3.3 After the test strip is dripped, wait for 1 minute for chemical reaction, then turn on the large plane light source in the test strip detection module 8 for illumination, and the CCD camera scans and takes pictures and transmits them to the computer for analysis;

[0090] 3.4 After the test strips are analyzed, the packaging robot 705 continues to lift and lower the test strips on the table 703 and push them onto the slope at the edge of the table 703 one by one. The test strips slide from the slope into the waste box.

[0091] 4. Centrifugal Concentration of Cells

[0092] After the liquid is dripped onto the chemical test strip, the test tube rack conveying module 6 is flattened and then moved forward to the automatic separation component 9, and the test tube 3 in the test tube rack 4 on the support plate 609 is aligned with the tightening column 908, and the tightening column 908 is pushed forward by the telescopic driving member 903. At this time, the tightening column 908 is inserted into the test tube rack 4 and contacts the free end of the drainage cap plug 312 on the corresponding test tube 3, and the end of the drainage tube 310 is contacted and covered with the liquid blocking plug in the drainage cap plug 312, thereby closing the drainage hole 313.

[0093] The first linear moving component 601 drives the upper part of the sliding plate 602 to move to the side of the cell centrifugal concentration module 10, and the test tube rack 4 is grabbed by the grabbing and transferring module 12 and placed on the tray 1002 in the centrifugal container 1001. The clamping structure on the tray 1002 clamps the test tube rack 4, and the protective cover pushing cylinder 1005 drives the protective cover 1003 to close. After the centrifugal concentration is completed, the protective cover pushing cylinder 1005 drives the protective cover 1003 to open.

[0094] 5. Microscopic analysis of cell morphology

[0095] The grabbing and transferring module 12 grabs the test tube rack 4 on the tray 1002 in the centrifuge container 1001, moves it to the test tube rack fixing plate 1105 in the cell morphology scanning module 11, fixes the test tube rack 4 by the limiting piece, scans the cover 306 in the test tube 3 by the high-power objective lens 1106 and the low-power objective lens 1107, the Z-axis moving module 1109 leads the object lens to focus, and the X-axis and Y-axis moving modules 1104 drive the test tube 3 on the test tube rack fixing plate 1105 to move for scanning, and after scanning and taking pictures, the pictures are transmitted to the computer for cell recognition and analysis. After the analysis is completed, the grabbing and transferring module 12 grabs the test tube rack 4 and removes the test tube rack fixing plate 1105. The grabbing and transferring module 12 releases the test tube rack 4, and the test tube rack 4 enters the discard box through the waste outlet 2 on the base 1.

[0096] In summary, the multi-item body fluid analyzer of the present invention has the following features:

[0097] 3. The biggest feature of this instrument is that it adopts needle-free and liquid-free pipeline technology. All chemical tests of test strips and cell morphology tests are automatically completed in one test tube. The entire instrument processing process only requires moving the test tube to different stations to complete the test;

[0098] 4. The instrument uses multiple test tube samples on the test tube rack as the operation unit, and processes and tests multiple specimens at one time. All you need to do is move the test tube rack to each test module to complete each test item, which greatly saves the test time and reduces the complexity of the instrument. The existing instruments on the market use each person's specimen as the processing unit;

[0099] 3. The instrument's detection modules are shared by various specimens, which simplifies the instrument, saves a lot of costs, and realizes multi-sample and multi-item detection in one: including urine, leucorrhea, stool and other body fluid samples; multiple chemical test strips and microscope cell morphology multi-item detection;

[0100] 4. Detection technology: The test strip detection module innovatively adopts a mode combining CCD camera, large area light source and computer image analysis software, which can detect multiple test strips and multiple samples at the same time. Compared with the diode, image sensor and microcomputer chip as detection devices on the market, the analysis accuracy is greatly improved, and the detection speed is increased by dozens of times; the cell centrifugal concentration module adopts a unique rack centrifugation, which does not require inserting test tubes one by one into the centrifugal container, but automatically puts the test tube rack with multiple test tubes into the centrifugal container at one time through the grabbing and transferring module, and realizes the whole urine centrifugal sediment cell inspection, which improves the accuracy of detection;

[0101] 5. The test strip dispensing module innovatively adopts box-type magazine flat push loading during the test strip loading process, avoiding the time-consuming material retrieval, test strip crooked, reversed, stuck, and dropped problems that occur in the drum-type loading on the market;

[0102] 6. Full automation: All items of all specimens are fully automated. The operator only needs to put the test tube containing the sample liquid into the test tube rack, install the test tube rack to the test tube rack loading module, and load the test strip storage box containing 50-100 chemical test strips into the test strip packaging module. The rest is completed by the instrument in a fully automated manner: automatic loading, mixing, dripping, constant temperature, test strip detection, centrifugation, microscope cell morphology detection, and waste disposal, realizing unattended full automation.

[0103] The instrument is a fully automatic instrument, which is suitable for both large tertiary hospitals and small hospitals. Urine, leucorrhea and stool are the three routine items in hospitals, so the demand is particularly large. In addition, the instrument has a simple structure, and the specimen modules are shared, so the production cost is extremely low. The instrument is stable, has few faults, and has a fast detection speed, so it has broad market prospects.

[0104] The above specific examples are used to illustrate the present invention, which are only used to help understand the present invention and are not used to limit the present invention. For those skilled in the art to which the present invention belongs, some simple deductions, modifications or substitutions can be made according to the idea of ​​the present invention.

Claims

1. A multi-item body fluid analyzer, characterized in that: It includes a base, a test tube, a test tube rack, a test tube rack loading module, a test tube rack conveying module, a test strip packaging module, a test strip detection module, a cell centrifugation concentration module, a cell morphology scanning module and a grabbing and transferring module; A plurality of test tubes are installed side by side inside the test tube rack, a test tube rack loading module is provided on the top of the base, the test tube rack is movably installed on the test tube rack loading module, the test tube rack conveying module is provided on the side of the test tube rack module, the test tube rack loading module drives the test tube rack to move, and pushes the test tube rack to be installed on the test tube rack conveying module, a test strip dispensing module and a cell centrifuge concentration module are provided on the top of the base along the conveying direction of the test tube rack conveying module, the test tube rack conveying module drives the test tube rack to move and rotate, and controls the test tubes in the test tube rack to correspond to the test strips in the test strip dispensing module, the test strip detection module is located on the base and above the test strip dispensing module, the cell morphology scanning module is provided on the outside of the cell centrifuge concentration module, and the grabbing and transferring module grabs the test tube rack on the test tube rack conveying module to the cell centrifuge concentration module and the cell morphology scanning module in sequence; The test tube comprises a tube body, a cover plug is slidably and sealedly installed at an opening of one end of the tube body, a drainage tube is arranged at an opening of the other end of the tube body, the end of the drainage tube is covered with a drainage cap plug, a liquid blocking plug is arranged inside the drainage cap plug, and the liquid blocking plug is in movable sealing contact with the end of the drainage tube; The base is provided with an automatic separation component for separating and covering the drain tube from the liquid blocking plug in the drain cap plug, and the automatic separation component includes a pull claw and a tightening column, the end of the tightening column can be movably extended into the inside of the test tube rack and contact with the free end of the drain cap plug on the corresponding test tube, and a plurality of plug-in slots are formed inside the pull claw, and the drain cap plug on the test tube can be movably inserted into the plug-in slot; The test tube rack conveying module is provided with a liquid discharge push rod, and the end of the liquid discharge push rod is in movably contact with the cover plug at the end of the test tube inside the test tube rack.

2. The multi-item body fluid analyzer according to claim 1, characterized in that: The tube body is open at both ends and has a hollow interior. A drainage hole is provided on the side of the drainage cap plug. The side of the tube body away from the end of the cap plug is opened to form a liquid guide groove. A transparent cover body is movably sealed and installed at the liquid guide groove.

3. The multi-item body fluid analyzer according to claim 2, characterized in that: A liquid blocking member is provided at the connection between the liquid inlet groove and the tube body, and a liquid flow channel for connecting the inside of the tube body and the liquid inlet groove is provided inside the liquid blocking member. The height of the liquid flow channel close to the liquid inlet groove is lower than the height close to the tube body.

4. The multi-item body fluid analyzer according to claim 3, characterized in that: The liquid blocking member is provided with a filter mesh slot near one end of the liquid guiding groove, and a filter mesh is inserted in the filter mesh slot.

5. The multi-item body fluid analyzer according to any one of claims 2 to 4, characterized in that: The automatic separation component is fixedly mounted on the test strip detection module through a fixing seat, and the automatic separation component is located between the test tube rack conveying module and the test strip packaging module, the automatic separation component includes a U-shaped mounting member, a telescopic driving member, a sliding member, a connecting member and a first fixed plate, the U-shaped mounting member is fixedly mounted on the bottom of the fixing seat, the sliding member is slidably mounted inside the U-shaped mounting member, the end of the telescopic driving member is connected to one end of the sliding member, driving the sliding member to move forward and backward inside the U-shaped mounting member, the first fixed plate is connected to the sliding member through a connecting member, and a plurality of tightening columns and pulling claws are installed on the first fixed plate, and the tightening columns and the pulling claws are staggered front and back.

6. The multi-item body fluid analyzer according to claim 1, characterized in that: The test tube rack conveying module comprises a first linear moving component, a sliding plate, a mounting seat, a rotating motor, a rotating rod, a connecting frame, an oscillator, an electric heating constant temperature plate, a supporting plate and an elastic clamping fixing part, the first linear moving component is fixedly mounted on the top of the base, and the first linear moving component is connected to the sliding plate located above it, two mounting seats are symmetrically arranged on the top of the sliding plate, the rotating rod is rotatably connected between the two mounting seats, one end of the rotating rod is driven and connected to the rotating motor, the connecting frame is fixedly mounted on the rotating rod, the top of the connecting frame is sequentially connected to the oscillator and the electric heating constant temperature plate, the top of the electric heating constant temperature plate is provided with a supporting plate for placing the test tube rack, the supporting plate is provided with an elastic clamping fixing part for clamping and fixing the outer side of the test tube rack, the top of the supporting plate is also provided with a drainage push cylinder, the output end of the drainage push cylinder is connected to the second fixed plate, and a plurality of drainage push rods are arranged side by side on the second fixed plate.

7. The multi-item body fluid analyzer according to claim 1, characterized in that: The test strip dispensing module includes a bottom plate, a fixed column, a table, a dispensing robot, a second linear motion component, a mounting plate, a feeding plate, a test strip storage box and a test strip pushing cylinder, wherein the bottom plate is located on the base, a plurality of fixed columns are fixed on the top of the bottom plate, a table and a mounting plate are fixedly mounted on the fixed columns, a plurality of grooves for placing test strips are arranged side by side on the table, the second linear motion component is located on the bottom plate, and the second linear motion component is fixedly connected to the dispensing robot located above it, the second linear motion component drives the dispensing robot to move in a direction perpendicular to the length of the test strip in the groove, and the top of the dispensing robot is connected to the groove A bracket is provided at a position corresponding to the groove, and an opening is provided on the table for the dispensing robot to pass through; the feeding plate is movably placed on the top of the mounting plate, and a receiving groove for holding the test strip is provided on the top of the feeding plate, and the length direction of the receiving groove is consistent with the length direction of the groove on the table, a test strip storage box is installed on the mounting plate, and an opening is provided at the bottom of the test strip storage box corresponding to the receiving groove, and the end of the feeding plate is connected to the test strip pushing cylinder, and driven by the test strip pushing cylinder, the feeding plate moves toward or away from the table, and an opening is provided on the feeding plate at the receiving groove for the dispensing robot to pass through.

8. The multi-item body fluid analyzer according to claim 7, characterized in that: The bottom of the base plate is hinged to the top of the base at one end away from the test tube rack conveying module, and an electric push rod is hingedly installed inside the base. The output end of the electric push rod passes through the base and is connected to the bottom of the base plate.

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