Preparation method of borneol powder in anshen niuhuang pill

Abstract

The application belongs to the technical field of traditional Chinese medicine processing, and particularly relates to a preparation method of borneol powder in Angong Niuhuang Pills, which comprises the following steps: 1) taking a proper amount of pearls and pulverizing by water flying method to prepare pearl water flying superfine powder with a water content of less than or equal to 5%; 2) uniformly mixing the prescription amount of pearl water flying superfine powder and the prescription amount of solid borneol or borneol ethanol solution, and grinding in a ball mill under the conditions of a temperature of-15 to-5 DEG C, a rotating speed of 50 to 60 rpm and a grinding time of 25 to 30 min, to obtain pearl-borneol powder for Angong Niuhuang Pill production; wherein the borneol ethanol solution is obtained by dissolving the prescription amount of borneol in 1.5 times of anhydrous ethanol. The method realizes the purpose of retarding borneol volatilization and guaranteeing the quality of Angong Niuhuang Pills by co-grinding borneol or borneol ethanol solution with pearl water flying superfine powder, and is simple in operation and does not need to add additional auxiliary materials.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of traditional Chinese medicine processing, and particularly relates to a preparation method of borneol powder in an Gongniujiang Pill medicine. BACKGROUND

[0002] The Gongniujiang Pill is the most famous emergency medicine in traditional Chinese medicine in China. It originates from the Shangjing Chapter of the Plague Differentiation by Wu Jutong, a plague scholar in the Qing Dynasty, and is one of the three best medicines for treating high fever in traditional Chinese medicine. The Gongniujiang Pill is composed of 11 kinds of medicines, including cow-bezoar, curcuma, rhinoceros horn, musk, pearl, gardenia, goldthread, radix scrophulariae, realgar, and borneol. The Gongniujiang Pill has the effects of clearing heat and resolving toxins, calming and opening the orifices, and is used for treating high fever, coma, wind stroke, facial paralysis, muscle and tendon traction, and phlegm and epilepsy.

[0003] The national medicine standard prescription of the Gongniujiang Pill is “100 g of cow-bezoar, 25 g of musk (or artificial musk), 200 g of water buffalo horn concentrated powder, 50 g of pearl, 100 g of realgar, 100 g of borneol, 100 g of goldthread, 100 g of radix scrophulariae, 100 g of gardenia, and 100 g of curcuma”. According to the whole prescription and the results of pharmacological studies, borneol plays a very important role in the Gongniujiang Pill and is a key promoting medicine for the Gongniujiang Pill acting on the nervous system of the brain, and has a great influence on the whole prescription.

[0004] The national medicine standard preparation method of the Gongniujiang Pill is “the above-mentioned 11 kinds of medicines are finely ground, the pearl is water-floated or finely powdered, the realgar and realgar are separately water-floated into fine powder, the goldthread, radix scrophulariae, gardenia, and curcuma are finely powdered, the cow-bezoar, water buffalo horn concentrated powder, artificial musk, and borneol are finely ground, the powders are mixed and ground, sieved, mixed, and then 600 or 1200 large honeyed pills are prepared or gold is coated, and the Gongniujiang Pill is obtained”. In the production, storage, and sales of the pill, it is found that borneol is extremely volatile, not only a part of borneol is lost in the production process of the pill, but also borneol is continuously lost in the storage of the finished product, and finally the content of borneol in the pill is reduced in the clinical use of the pill. The results of pharmacological studies on the Gongniujiang Pill and borneol show that the Gongniujiang Pill has a strong pharmacological effect on the nervous system of the brain, borneol not only has the same pharmacological effect, but also promotes and strengthens the effect of other medicines in the prescription on the nervous system of the brain, and borneol is a key component medicine in the prescription. The loss of borneol will inevitably weaken the pharmacological effect of the medicine and affect the clinical curative effect of the Gongniujiang Pill.

[0005] Therefore, it is necessary to improve the preparation method of borneol in the Gongniujiang Pill to ensure the quality of the Gongniujiang Pill. SUMMARY

[0006] The present application aims at overcoming the above problems existing in the prior art, and provides a preparation method of borneol powder in Angelicae Sinensis Radix and Bovis Calculus Pill.

[0007] To achieve the above technical purposes and effects, the present application is implemented by the following technical solutions.

[0008] The preparation method of borneol powder in Angelicae Sinensis Radix and Bovis Calculus Pill comprises the following steps:

[0009] 1) A proper amount of pearls is taken and pulverized by water flying method to prepare pearl water flying superfine powder with a water content of less than or equal to 5%;

[0010] 2) The prescription amount of pearl water flying superfine powder is mixed with the prescription amount of solid borneol or borneol ethanol solution, and then grinded in a ball mill at a temperature of-15 to-5℃ and a rotation speed of 50 to 60 rpm for 25 to 30 minutes to obtain pearl-borneol powder for the production of Angelicae Sinensis Radix and Bovis Calculus Pill.

[0011] Further, in the preparation method of borneol powder in Angelicae Sinensis Radix and Bovis Calculus Pill as described above, the borneol ethanol solution in step 2) is obtained by dissolving the prescription amount of borneol with 1.5 times of anhydrous ethanol.

[0012] Further, in the preparation method of borneol powder in Angelicae Sinensis Radix and Bovis Calculus Pill as described above, when the prescription amount of solid borneol is used in step 2), the powder fineness of the pearl water flying superfine powder in step 1) satisfies that all the powder can pass through a 150-mesh standard sieve, and more than 95% of the powder can pass through a 200-mesh standard sieve.

[0013] Further, in the preparation method of borneol powder in Angelicae Sinensis Radix and Bovis Calculus Pill as described above, when the prescription amount of solid borneol is used in step 2), the pearl-borneol powder obtained in step 2) satisfies that all the powder can pass through a 120-mesh standard sieve.

[0014] Further, in the preparation method of borneol powder in Angelicae Sinensis Radix and Bovis Calculus Pill as described above, when the prescription amount of borneol ethanol solution is used in step 2), the powder fineness of the pearl water flying superfine powder in step 1) satisfies that more than 95% of the powder can pass through a 200-mesh standard sieve.

[0015] Further, in the preparation method of borneol powder in Angelicae Sinensis Radix and Bovis Calculus Pill as described above, when the prescription amount of borneol ethanol solution is used in step 2), the pearl-borneol powder obtained in step 2) satisfies that all the powder can pass through a 150-mesh standard sieve, and more than 95% of the powder can pass through a 200-mesh standard sieve.

[0016] The present application has the following beneficial effects:

[0017] Generally, to prevent the loss of volatile materials such as borneol during the preparation process, the beta-cyclodextrin is usually used for embedding. Although the use of this method prevents the loss of volatile components, it additionally increases new excipients, and the embedding process is relatively complicated. Through the observation of the powder particle microstructure of the water fly pearl superfine powder, it is known that the aragonite structure of the pearl micro-powder is composed of aragonite flake plates, there are gaps between the flake plates, and there are numerous nanoscale holes left by the disappearance of organic matter. The method uses these pores of the pearl micro-powder structure to co-mill borneol or borneol alcohol solution, embeds borneol particles in the gaps between the aragonite flake plates, hinders the movement of borneol molecules, and achieves the purpose of delaying and hindering the volatilization of borneol. Therefore, the method co-mills borneol or borneol alcohol solution with the water fly pearl superfine powder, realizes the purpose of retarding the volatilization of borneol, and guarantees the quality of the An Gong Niuhuang Pill, which is not only simple in operation, but also does not need to add additional excipients.

[0018] Of course, implementing any product of the present application does not necessarily require achieving all the advantages above at the same time. DETAILED DESCRIPTION

[0019] The technical solutions in the embodiments of the present application will be clearly and completely described below. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by a person of ordinary skill in the art without creative labor fall within the protection scope of the present application.

[0020] The related specific embodiments of the present application are as follows:

[0021] Embodiment 1

[0022] A preparation method of borneol powder in an An Gong Niuhuang Pill medicine, comprising the following steps:

[0023] 1) A proper amount of pearls is pulverized by the water fly method to prepare pearl water fly superfine powder with a water content of 4.8%; the powder fineness of the pearl water fly superfine powder meets the requirements that all the powder can pass through a 150-mesh standard sieve, and more than 95% of the powder can pass through a 200-mesh standard sieve.

[0024] 2) The prescription amount of pearl water fly superfine powder is uniformly mixed with the prescription amount of solid borneol, and is ground in a ball mill under the conditions of a temperature of-15℃ and a rotation speed of 50 rpm for 30 min, to obtain pearl-borneol powder for the production of the An Gong Niuhuang Pill. The obtained pearl-borneol powder meets the requirements of powder fineness that all the powder can pass through a 120-mesh standard sieve.

[0025] Embodiment 2

[0026] A preparation method of borneol powder in an An Gong Niuhuang Pill medicine, comprising the following steps:

[0027] 1) Take the appropriate amount of pearls and water fly method of crushing, made of water content of 4.8% pearl water fly fine powder; pearl water fly fine powder powder fineness meet: all can pass 150 standard sieve, more than 95% of the powder can pass 200 standard sieve.

[0028] 2) The production of prescription amount of pearl water fly fine powder and prescription amount of solid borneol mixed, placed in a ball mill grinding, in -10 ℃ temperature, 55 rpm speed conditions grinding 28 min, obtained for the production of Angong Niuhuang pill pearl-borneol powder. The fineness of the obtained pearl-borneol powder meets: all can pass 120 standard sieve.

[0029] The pearl-borneol powder prepared in this example and the remaining prescription of the production of Angong Niuhuang pill, according to the process and order of Angong Niuhuang pill drug standard preparation method of feeding production, preparation of Angong Niuhuang pill.

[0030] Take the prepared Angong Niuhuang pill, and Angong Niuhuang pill prepared according to the drug standard preparation method, respectively with aluminum plastic blister package, avoid light placed in long-term stability test box, respectively in the 0, 1, 2, 3, 6, 9, 12 month sampling observation blister film wall on the borneol volatile, and using gas chromatography method to detect borneol content. The results are shown in Table 1 as follows:

[0031] Table 1

[0032]

[0033]

[0034] It can be seen that compared with the drug standard preparation method, the pearl-borneol powder prepared by the method of this example is used to produce Angong Niuhuang pill, which can better reduce the volatilization loss of borneol and ensure the quality of Angong Niuhuang pill.

[0035] Example 3

[0036] A method for preparing borneol powder in Angong Niuhuang pill medicine, comprising the following steps:

[0037] 1) Take the appropriate amount of pearls and water fly method of crushing, made of water content of 4.8% pearl water fly fine powder; pearl water fly fine powder powder fineness meet: all can pass 150 standard sieve, more than 95% of the powder can pass 200 standard sieve.

[0038] 2) The production of prescription amount of pearl water fly fine powder and prescription amount of solid borneol mixed, placed in a ball mill grinding, in -5 ℃ temperature, 60 rpm speed conditions grinding 25 min, obtained for the production of Angong Niuhuang pill pearl-borneol powder. The fineness of the obtained pearl-borneol powder meets: all can pass 120 standard sieve.

[0039] Example 4

[0040] A preparation method of borneol powder in An Gong Niuhuang pills, comprising the following steps:

[0041] 1) Take an appropriate amount of pearls and crush them by water flying method to produce pearl water flying ultrafine powder with a water content of 4.8%; the powder fineness of the pearl water flying ultrafine powder meets the requirements that all can pass through a 150-mesh standard sieve, and more than 95% of the powder can pass through a 200-mesh standard sieve.

[0042] 2) Mix the pearl water flying ultrafine powder of the production prescription amount with borneol ethanol solution, and the borneol ethanol solution is obtained by dissolving the production prescription amount of borneol with 1.5 times of anhydrous ethanol; grind in a ball mill at a temperature of-15℃ and a speed of 50 rpm for 30 min to obtain pearl-borneol powder for the production of An Gong Niuhuang pills. The obtained pearl-borneol powder meets the requirements that all can pass through a 120-mesh standard sieve.

[0043] Example 5

[0044] A preparation method of borneol powder in An Gong Niuhuang pills, comprising the following steps:

[0045] 1) Take an appropriate amount of pearls and crush them by water flying method to produce pearl water flying ultrafine powder with a water content of 4.8%; the powder fineness of the pearl water flying ultrafine powder meets the requirements that all can pass through a 150-mesh standard sieve, and more than 95% of the powder can pass through a 200-mesh standard sieve.

[0046] 2) Mix the pearl water flying ultrafine powder of the production prescription amount with borneol ethanol solution, and the borneol ethanol solution is obtained by dissolving the production prescription amount of borneol with 1.5 times of anhydrous ethanol; grind in a ball mill at a temperature of-10℃ and a speed of 55 rpm for 28 min to obtain pearl-borneol powder for the production of An Gong Niuhuang pills. The obtained pearl-borneol powder meets the requirements that all can pass through a 120-mesh standard sieve.

[0047] Example 6

[0048] A preparation method of borneol powder in An Gong Niuhuang pills, comprising the following steps:

[0049] 1) Take an appropriate amount of pearls and crush them by water flying method to produce pearl water flying ultrafine powder with a water content of 4.8%; the powder fineness of the pearl water flying ultrafine powder meets the requirements that all can pass through a 150-mesh standard sieve, and more than 95% of the powder can pass through a 200-mesh standard sieve.

[0050] 2) The production of the prescription amount of pearl water fly extremely fine powder and menthol ethanol solution, menthol ethanol solution is by the production of the prescription amount of menthol with 1.5 times of anhydrous ethanol solution; placed in the ball mill grinding, in-5 ℃ temperature, 60 rpm speed conditions for 25 min, obtained for the production of An Gong Niuhuang pill pearl-menthol powder. The fineness of the obtained pearl-menthol powder meets: all can pass through 120 mesh standard sieve.

[0051] The preferred embodiments of the application disclosed above are only used to help explain the application. The preferred embodiments do not describe all the details and limit the application to the specific embodiments. Obviously, many modifications and variations can be made according to the content of the specification. The specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the application, so that those skilled in the art can well understand and utilize the application. The application is limited only by the claims and their full scope and equivalents.

Claims

1. A method for preparing borneol powder for preparing Angong Niuhuang Wan (a traditional Chinese medicine), characterized in that, Includes the following steps: 1) Take an appropriate amount of pearls and grind them using the water-milling method to make pearl water-milled ultrafine powder with a moisture content of ≤5%; 2) Mix the prescribed amount of pearl water-milled ultrafine powder with the prescribed amount of solid borneol or borneol ethanol solution, place them in a ball mill and grind for 25 to 30 minutes at a temperature of -15 to -5℃ and a speed of 50 to 60 rpm to obtain pearl-borneol powder for the production of Angong Niuhuang Wan.

2. The preparation method according to claim 1, characterized in that, In step 2), the borneol ethanol solution is obtained by dissolving the prescribed amount of borneol in 1.5 times the volume of anhydrous ethanol.

3. The preparation method according to claim 1, characterized in that: When borneol is used in step 2) and the prescribed amount of solid borneol is used, the fineness of the pearl water-milled ultrafine powder in step 1) meets the following requirements: all of it can pass through a 150-mesh standard sieve, and more than 95% of the powder can pass through a 200-mesh standard sieve.

4. The preparation method according to claim 1, characterized in that: When borneol is used in step 2) in the prescribed amount of solid borneol, the fineness of the pearl-borneol powder obtained in step 2) meets the requirement that all of it can pass through a 120-mesh standard sieve.

5. The preparation method according to claim 1, characterized in that: When borneol is used in step 2) with the prescribed amount of borneol ethanol solution, the fineness of the pearl water-milled ultrafine powder in step 1) meets the following requirement: more than 95% of the powder can pass through a 200-mesh standard sieve.

6. The preparation method according to claim 1, characterized in that: When borneol is used in step 2) with the prescribed amount of borneol ethanol solution, the fineness of the pearl-borneol powder obtained in step 2) meets the following requirements: all of it can pass through a 150-mesh standard sieve, and more than 95% of it can pass through a 200-mesh standard sieve.

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