color column

Abstract

The application relates to the technical field of radioactive device, and provides a chromatographic column. The chromatographic column comprises a column component; a needle component connected with the column component; a clamping fixing assembly arranged at the connection position of the needle component and the column component; and the input end of the needle component, the input end of the column component, the output end of the column component and the output end of the needle component are sequentially sealed and communicated through the clamping of the needle component and the column component. According to the chromatographic column, the column component is first transported to a production link, the corresponding adsorbent is loaded into the column component, then the column component is moved out of the production link, the needle component and the column component are connected through the clamping fixing assembly, and then the needle component and the column component form the chromatographic column. Therefore, only the column component enters the production link, the needle component is clamped with the column component after the production link to form the chromatographic column, and the needle component which is in contact with the terminal is effectively prevented from being contaminated and carrying radioactivity.

Description

Technical Field

[0001] This application relates to the field of radioactive device technology, and more particularly to chromatographic columns. Background Technology

[0002] Radiochromatographic columns from radioisotope generators can provide carrier-free, high-specific-activity, and high-concentration short-half-life nuclides safely and conveniently and repeatedly, making them widely used in medicine, industry, and scientific research. The short-half-life nuclides obtained from radioisotope generator chromatographic columns can be used directly or formulated into a variety of labeled compounds (including pharmaceuticals). Among existing radioisotope generator chromatographic columns, the most widely used is... 99 Mo- 99m Tc generator color layer column. 99 Mo- 99m The eluent from the Tc generator chromatography column contains various components labeled with the raw material. 99m Tc drugs have been widely used for scanning and imaging and functional examinations of the brain, thyroid gland, salivary glands, lungs, heart, blood, liver, gallbladder, spleen, kidneys, bones, and bone marrow.

[0003] A radiochromatographic column for a radioisotope generator mainly consists of two parts: a container structure for loading the adsorbent and a needle structure that comes into direct contact with the end user. In related technologies, the container structure and needle structure of the chromatographic column are integrated, and the needle structure used by the customer needs to enter the production process together, making the needle structure susceptible to contamination and radioactivity. Summary of the Invention

[0004] This application aims to at least solve one of the technical problems existing in the related art. To this end, this application proposes a chromatographic column, which realizes that only the column component enters the production process, and then the needle component is snapped together with the column component to form the chromatographic column after the production process, effectively preventing the needle component that comes into contact with the end user from being contaminated and carrying radioactivity.

[0005] According to an embodiment of this application, the color layer column includes:

[0006] Column components;

[0007] A needle component is connected to the column component, and a snap-fit ​​fixing assembly is provided at the connection between the needle component and the column component;

[0008] The needle component and the column component are engaged so that the input end of the needle component, the input end of the column component, the output end of the column component, and the output end of the needle component are sequentially sealed and connected.

[0009] According to the chromatographic column of this application embodiment, the column component is first transported to the production stage, where a corresponding adsorbent is loaded into the column component. Then, the column component is removed from the production stage, and the needle component and column component are connected together using a snap-fit ​​fixing assembly, thereby forming a chromatographic column. This achieves the goal of only the column component entering the production stage, and then snapping the needle component and column component together to form the chromatographic column after production, effectively preventing the needle component, which comes into contact with the user terminal, from being contaminated and carrying radioactivity.

[0010] According to one embodiment of this application, the column component includes a connector, a first needle, a second needle, and a container. The first needle and the second needle are both installed in the connector. The first needle is connected to the inlet of the container, and the second needle is connected to the outlet of the container.

[0011] According to one embodiment of this application, the connector engages with the needle component, such that the input end of the needle component, the first needle, the container, the second needle, and the output end of the needle component are sequentially sealed and connected.

[0012] According to one embodiment of this application, both the first needle and the second needle are fitted with a telescopic sealing protective sleeve.

[0013] According to one embodiment of this application, the end of the telescopic sealing protective sleeve near the container is fixedly connected to the connecting seat.

[0014] According to one embodiment of this application, the column component includes a limiting and fixing block, which is mounted on the connecting seat and is used to fix one end of the telescopic sealing protective sleeve away from the container on the connecting seat.

[0015] According to one embodiment of this application, the lower surface of the connector is provided with a plurality of locking blocks, and the limiting fixing block is provided with a protrusion that abuts against the locking blocks, the protrusion being located between the locking blocks and the lower surface of the connector.

[0016] According to one embodiment of this application, the connecting seat is provided with a through hole that matches the telescopic sealing protective sleeve, and a first groove is provided on the side of the connecting seat away from the needle component. One end of the telescopic sealing protective sleeve passes through the through hole, and the other end of the telescopic sealing protective sleeve is located between the limiting fixing block and the first groove.

[0017] According to one embodiment of this application, the column component includes a first conduit and a second conduit. The side of the connector near the container is provided with a plurality of snap-fit ​​blocks that match the first conduit and the second conduit. The first conduit connects the first needle and the inlet of the container, and the second conduit connects the second needle and the outlet of the container.

[0018] According to one embodiment of this application, the column component includes a first conduit and a second conduit. The container, including a tube body, is disposed on the side of the connector seat near the container. A first connector is disposed at the upper end of the tube body, and a second connector is disposed at the lower end of the tube body. The first conduit passes through the first connector and communicates with the tube body, and the second conduit passes through the second connector and communicates with the tube body. A sealing element is disposed at the connection between the first connector and the tube body and at the connection between the second connector and the tube body.

[0019] According to one embodiment of this application, the first connector is provided with a limiting groove that matches the second conduit.

[0020] According to one embodiment of this application, the needle component includes a needle hub, a single needle assembly, and a double needle assembly. The single needle assembly and the double needle assembly are respectively mounted on the needle hub. The needle hub is engaged with the connecting seat so that the double needle assembly, the first needle, the container, the second needle, and the single needle assembly are sequentially sealed and connected.

[0021] According to one embodiment of this application, the single-needle assembly includes a third needle tip and a first sealing connector connected in sequence, wherein the needle seat engages with the connector seat such that the second needle tip is inserted into the first sealing connector.

[0022] According to one embodiment of this application, the single-needle assembly includes a first filter, and the third needle, the first filter, and the first sealing connector are connected in sequence.

[0023] According to one embodiment of this application, the dual-needle assembly includes a fourth needle, an air filter, and a fifth needle and a second sealing connector connected in sequence. One end of the fourth needle is connected to the air filter, and the needle seat engages with the connector seat such that the first needle is inserted into the second sealing connector.

[0024] According to one embodiment of this application, the snap-fit ​​fixing component includes at least one of the following:

[0025] The locking strip and locking groove cooperate with each other, one of which is provided on the connecting seat and the other is provided on the pin seat;

[0026] The first and second latches cooperate with each other, one of which is disposed on the connecting seat and the other is disposed on the needle seat.

[0027] According to one embodiment of this application, the snap-fit ​​strip is provided with a second groove, and the end of the snap-fit ​​strip near the snap-fit ​​groove is provided with an inclined surface, and the snap-fit ​​groove is provided with a protrusion that matches the second groove.

[0028] Additional aspects and advantages of this application will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of this application. Attached Figure Description

[0029] To more clearly illustrate the technical solutions in the embodiments or related technologies of this application, the accompanying drawings used in the description of the embodiments or related technologies will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0030] Figure 1 This is an exploded view of the structure of the color layer column provided in the embodiments of this application;

[0031] Figure 2 This is a schematic diagram of the structure of the color layer column provided in the embodiment of this application;

[0032] Figure 3 This is a cross-sectional view of the color layer column provided in the embodiment of this application;

[0033] Figure 4 This is one of the structural schematic diagrams of the column component of the color layer column provided in the embodiments of this application;

[0034] Figure 5 This is a cross-sectional view of the column component of the color layer column provided in the embodiment of this application;

[0035] Figure 6 This is an exploded view of the column component of the color layer column provided in the embodiments of this application;

[0036] Figure 7 This is the second schematic diagram of the structure of the column component of the color layer column provided in the embodiments of this application;

[0037] Figure 8 This is one of the structural schematic diagrams of the needle component of the color layer column provided in the embodiments of this application;

[0038] Figure 9 This is a cross-sectional view of the needle component of the color layer column provided in the embodiments of this application;

[0039] Figure 10This is the second schematic diagram of the structure of the needle component of the color layer column provided in the embodiments of this application;

[0040] Figure label:

[0041] 1. Column component; 2. Needle component; 3. Snap-fit ​​fixing assembly; 11: Connector; 12: First needle; 13: Second needle; 14: Container; 15: Telescopic sealing protective sleeve; 16: Limiting fixing block; 17: First guide tube; 18: Second guide tube; 21: Needle seat; 22: Single needle assembly; 23: Double needle assembly; 31: Snap-fit ​​strip; 32: Snap-fit ​​groove; 111: Snap-fit ​​block; 112: First groove; 113: Snap-fit ​​block; 141: Tube body; 142: First connector; 143: Second connector; 144: Limiting groove; 161: Protrusion; 221: Third needle; 222: First sealing connector; 223: First filter; 231: Fourth needle; 232: Air filter; 233: Fifth needle; 234: Second sealing connector; 311: Second groove; 312: Inclined surface; 321: Protrusion. Detailed Implementation

[0042] The embodiments of this application will be described in further detail below with reference to the accompanying drawings and examples. The following examples are used to illustrate this application, but should not be used to limit the scope of this application.

[0043] In the description of the embodiments of this application, it should be noted that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing the embodiments of this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the embodiments of this application. In addition, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0044] In the description of the embodiments of this application, it should be noted that, unless otherwise explicitly specified and limited, the terms "connected" and "linked" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium. Those skilled in the art can understand the specific meaning of the above terms in the embodiments of this application based on the specific circumstances.

[0045] In the embodiments of this application, unless otherwise expressly specified and limited, "above" or "below" the second feature can mean that the first feature is in direct contact with the second feature, or that the first feature is in indirect contact with the second feature through an intermediate medium. Furthermore, "above," "on top of," and "over" the second feature can mean that the first feature is directly above or diagonally above the second feature, or simply that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply that the first feature is at a lower horizontal level than the second feature.

[0046] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., refer to specific features, structures, materials, or characteristics described in connection with that embodiment or example, which are included in at least one embodiment or example of the embodiments of this application. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0047] The following is combined Figures 1 to 10 Describe the color layer columns of this application.

[0048] According to the embodiments of this application, such as Figure 1 As shown, the color layer column includes:

[0049] Column component 1;

[0050] The needle component 2 is connected to the column component 1, and a snap-fit ​​fixing component 3 is provided at the connection between the needle component 2 and the column component 1.

[0051] The needle component 2 and the column component 1 are engaged so that the input end of the needle component 2, the input end of the column component 1, the output end of the column component 1 and the output end of the needle component 2 are sequentially sealed and connected.

[0052] In use, column component 1 is first transported to the production stage, where the appropriate adsorbent is loaded. Then, column component 1 is removed from the production stage, and needle component 2 and column component 1 are connected together using snap-fit ​​assembly 3, thus forming a chromatographic column. This achieves the goal of only column component 1 entering the production stage, and then snapping needle component 2 together with column component 1 to form a chromatographic column, effectively preventing needle component 2 from being contaminated with radioactivity upon contact with the end user.

[0053] In one embodiment of this application, such as Figure 2 and Figure 3 As shown, column component 1 includes a connecting seat 11, a first needle 12, a second needle 13, and a container 14. Both the first needle 12 and the second needle 13 are installed within the connecting seat 11. The first needle 12 communicates with the inlet of the container 14, and the second needle 13 communicates with the outlet of the container 14. In use, the eluent is introduced into the container 14 through the first needle 12. After contacting the adsorbent in the container 14, the eluent is output through the second needle 13, thus obtaining a solution carrying high radioactivity. Furthermore, compared to soft chromatography columns in related technologies, the chromatography column in this embodiment consists of a connecting seat 11, a container 14, and corresponding needles, all of which are components with a certain degree of rigidity, eliminating the need for additional support structures and facilitating the production of chromatography columns.

[0054] In embodiments of this application, container 14 is, for example, a glass column. However, it should be understood that container 14 can also be any other suitable structure or material.

[0055] In one embodiment of this application, such as Figure 2 and Figure 3 As shown, the connector 11 engages with the needle component 2, sealing the input end of the needle component 2, the first needle 12, the container 14, the second needle 13, and the output end of the needle component 2 sequentially. In use, the column component 1 is first transported to the production stage, the adsorbent is loaded into the container 14, and then the column component 1 is removed from the production stage. Then, the connector 11 engages with the needle component 2, sealing the input end of the needle component 2 with the first needle 12 and the output end with the second needle 13. When used by the user terminal, the eluent is transported through the input end of the needle component 2 to the first needle 12, enters the container 14 through the first needle 12 to contact the adsorbent, and then moves to the output end of the needle component 2 through the second needle 13. This achieves a radioactive solution obtained under sealed conditions, making it safer. Furthermore, this ensures that only the column component 1 enters the production stage, and then the needle component 2 is engaged with the column component 1 after production to form a chromatography column, effectively preventing the needle component 2, which comes into contact with the user terminal, from becoming contaminated and carrying radioactivity.

[0056] In the embodiments of this application, such as Figure 3 and Figure 6As shown, both the first needle 12 and the second needle 13 are fitted with telescopic sealing protective sleeves 15. During use, by providing telescopic sealing protective sleeves 15 to the first needle 12 and the second needle 13, the telescopic sealing protective sleeves 15 prevent the first needle 12 and the second needle 13 from being exposed to the external environment. When the connecting seat 11 is engaged with the needle component 2, the first needle 12 passes through the telescopic sealing protective sleeve 15 and is inserted into the input end of the needle component 2, while the second needle 13 passes through the telescopic sealing protective sleeve 15 and is inserted into the output end of the needle component 2. The telescopic sealing protective sleeve 15 then retracts downwards. When the column component 1 disengages from the needle component 2, the connecting seat 11 and the needle component 2 are no longer engaged, and the first needle 12 and the second needle 13 gradually disengage from the needle component 2. Simultaneously, the telescopic sealing protective sleeve 15 gradually returns to its original shape, ensuring that the first needle 12 and the second needle 13 are enclosed within the telescopic sealing protective sleeve 15, effectively preventing the first needle 12 and the second needle 13 from contacting the external environment.

[0057] In one embodiment of this application, such as Figure 3 , Figure 5 and Figure 6 As shown, the telescopic sealing protective sleeve 15 is fixedly connected to the connecting seat 11 at one end near the container 14. During use, the telescopic sealing protective sleeve 15 is respectively fitted onto the first needle 12 and the second needle 13, and the telescopic sealing protective sleeve 15 is fixedly connected to the connecting seat 11. This effectively prevents the telescopic sealing protective sleeve 15 from detaching when the connecting seat 11 detaches from the needle component 2, ensuring that the telescopic sealing protective sleeve 15 is always fitted onto the first needle 12 and the second needle 13.

[0058] In one embodiment of this application, such as Figure 3 , Figure 5 , Figure 6 and Figure 7 As shown, the column component 1 includes a limiting and fixing block 16, which is mounted on the connecting seat 11. The limiting and fixing block 16 is used to fix the end of the telescopic sealing protective sleeve 15 away from the container 14 to the connecting seat 11. In use, the telescopic sealing protective sleeve 15 is respectively fitted onto the first needle 12 and the second needle 13. The first needle 12 or the second needle 13 is inserted from the opening of the telescopic sealing protective sleeve 15, and then the opening end of the telescopic sealing protective sleeve 15 is fixed to the connecting seat 11 by the limiting and fixing block 16, so that the telescopic sealing protective sleeve 15 is fixed to the connecting seat 11, thereby preventing the telescopic sealing protective sleeve 15 on the first needle 12 or the second needle 13 from falling off, and ensuring that the first needle 12 and the second needle 13 are never in contact with the external environment.

[0059] In one embodiment of this application, such as Figure 3 , Figure 5 , Figure 6 and Figure 7 As shown, the lower surface of the connecting seat 11 is provided with multiple locking blocks 111, and the limiting fixing block 16 is provided with a protrusion 161 that abuts against the locking blocks 111. The protrusion 161 is located between the locking blocks 111 and the lower surface of the connecting seat 11. In use, the locking blocks 111 engage with the protrusion 161 on the limiting fixing block 16, so that the limiting fixing block 16 is fixedly installed on the connecting seat 11. Thus, the limiting fixing block 16 can effectively fix the telescopic sealing protective sleeve 15 on the connecting seat 11.

[0060] In one embodiment of this application, such as Figure 3 , Figure 5 , Figure 6 and Figure 7 As shown, the connecting seat 11 has a through hole that matches the telescopic sealing protective sleeve 15. A first groove 112 is provided on the side of the connecting seat 11 away from the needle component 2. One end of the telescopic sealing protective sleeve 15 passes through the through hole, and the other end of the telescopic sealing protective sleeve 15 is located between the limiting fixing block 16 and the first groove 112. In use, one end of the telescopic sealing protective sleeve 15 is passed through the through hole and fitted onto the needle (first needle 12 or second needle 13), so that the other end of the telescopic sealing protective sleeve 15 is engaged in the first groove 112. The limiting fixing block 16 then fixes the other end of the telescopic sealing protective sleeve 15 in the first groove 112, thus limiting the other end of the telescopic sealing protective sleeve 15 between the limiting fixing block 16 and the first groove 112, preventing the telescopic sealing protective sleeve 15 from falling off, and ensuring that the first needle 12 and the second needle 13 do not come into contact with the external environment, preventing radioactive contamination of the external environment.

[0061] In one embodiment of this application, such as Figure 3 , Figure 4 , Figure 5 , Figure 6 and Figure 7 As shown, the column component 1 includes a first conduit 17 and a second conduit 18. Multiple locking blocks 113, matching the first conduit 17 and the second conduit 18, are provided on the side of the connecting seat 11 near the container 14. The first conduit 17 connects the first needle 12 and the inlet of the container 14, and the second conduit 18 connects the second needle 13 and the outlet of the container 14. In use, one end of the first conduit 17 is connected to the first needle 12, and the other end is connected to the inlet of the container 14. One end of the second conduit 18 is connected to the second needle 13, and the other end is connected to the outlet of the container 14, thus connecting the first needle 12, the container 14, and the second needle 13. Furthermore, by locking the first conduit 17 and the second conduit 18 with the locking blocks 113 respectively, the first conduit 17 and the second conduit 18 become more stable and less prone to shaking, which is more beneficial for the production and use of the color layer column.

[0062] In the embodiments of this application, such as Figure 3 , Figure 4 , Figure 5 , Figure 6 and Figure 7 As shown, container 14 includes a tube body 141. A first connector 142 is located at the upper end of tube body 141, and a second connector 143 is located at the lower end of tube body 141. A first conduit 17 passes through the first connector 142 and communicates with tube body 141, and a second conduit 18 passes through the second connector 143 and communicates with tube body 141. Sealing elements are provided at the connections between the first connector 142 and tube body 141, and between the second connector 143 and tube body 141. In use, the first connector 142 and the second connector 143 are respectively engaged with the upper and lower openings of tube body 141. Then, the first conduit 17 passes through the first connector 142 and communicates with tube body 141, and the second conduit 18 passes through the second connector 143 and communicates with tube body 141, allowing liquid to enter tube body 141 through the first conduit 17 and exit tube body 141 through the second conduit 18. By providing sealing elements at the connection points of the first connector 142 and the tube body 141 and the second connector 143 and the tube body 141, the sealing of the connection between the first connector 142 and the second connector 143 and the tube body 141 is ensured, preventing radioactive materials inside the tube body 141 from polluting the external environment.

[0063] In embodiments of this application, the seal is, for example, a sealing ring. However, it should be understood that the seal can also be any other suitable structure with a sealing function.

[0064] In one embodiment of this application, such as Figure 7 As shown, the first connector 142 is provided with a limiting groove 144 that matches the second conduit 18. In use, one end of the second conduit 18 is connected to the second needle 13, and the other end of the second conduit 18 passes through the second connector 143 and communicates with the tube body 141. The second conduit 18 is engaged with the limiting groove 144, which prevents the second conduit 18 from shaking, so that the second conduit 18 can stably connect the second needle 13 and the tube body 141.

[0065] In one embodiment of this application, such as Figure 8 and Figure 9As shown, the needle component 2 includes a needle holder 21, a single needle assembly 22, and a double needle assembly 23. The single needle assembly 22 and the double needle assembly 23 are respectively mounted on the needle holder 21. The needle holder 21 is engaged with the connecting seat 11, so that the double needle assembly 23, the first needle tip 12, the container 14, the second needle tip 13, and the single needle assembly 22 are sequentially sealed and connected. In use, the double needle assembly 23 is inserted into a bottle containing eluent, and the single needle assembly 22 is inserted into a vacuum bottle. At this time, there is a pressure difference between the single needle assembly 22 and the double needle assembly 23. The eluent flows through the double needle assembly 23 to the first needle tip 12, and then flows through the first needle tip 12 into the container 14. After the eluent comes into contact with the adsorbent in the container 14, it flows through the second needle tip 13 back to the single needle assembly 22, and then flows into the vacuum bottle, thereby obtaining a radioactive solution. It is convenient to use. Furthermore, only the column component 1 can enter the production process. After the column component 1 leaves the production process, the needle seat 21 is then snapped into the connecting seat 11, so that the needle component 2 and the column component 1 are installed together. This can effectively prevent the needle component 2, which comes into contact with the user terminal, from being contaminated and carrying radioactivity.

[0066] In one embodiment of this application, such as Figure 8 and Figure 9 As shown, the single-needle assembly 22 includes a third needle 221 and a first sealing connector 222 connected in sequence. The needle seat 21 engages with the connector 11, allowing the second needle 13 to be inserted into the first sealing connector 222. In use, the connector 11 engages with the needle seat 21, and the second needle 13 is inserted into the first sealing connector 222. The telescopic sealing protective sleeve 15 on the second needle 13 contracts as it is squeezed. The third needle 221 is inserted into the vacuum bottle, allowing the eluent to enter the container 14, contact the adsorbent, and then flow through the second needle 13 to the first sealing connector 222, and then from the first sealing connector 222 to the third needle 221. The solution is collected in the vacuum bottle through the third needle 221. The first sealing connector 222 ensures that the second needle 13 remains isolated from the external environment. When the connector 11 detaches from the needle holder 21, the second needle 13 gradually moves away from the first sealing connector 222. Simultaneously, the telescopic sealing protective sleeve 15 on the second needle 13 gradually expands, enclosing the second needle 13. This ensures that the second needle 13 is always within the telescopic sealing protective sleeve 15 or always within both the telescopic sealing protective sleeve 15 and the first sealing connector 222.

[0067] In the embodiments of this application, such as Figure 8 and Figure 9As shown, the single-needle assembly 22 includes a first filter 223, a third needle 221, and a first sealing connector 222 connected in sequence. In use, the third needle 221 is inserted into the vacuum bottle, allowing the eluent to enter the container 14 and contact the adsorbent. After contact, the eluent flows through the second needle 13 to the first sealing connector 222, and then flows from the first sealing connector 222 to the first filter 223. The first filter 223 filters the solution and delivers it to the third needle 221. The solution is collected in the vacuum bottle after passing through the third needle 221. Terminal filtration of the solution is achieved through the first filter 223, ensuring the quality of the obtained radioactive solution.

[0068] In one embodiment of this application, a first sealing needle sleeve is provided on the third needle 221. During use, the first sealing needle sleeve can effectively isolate the third needle 221 from the outside world, preventing the third needle 221 from being contaminated by long-term exposure to the external environment. When the color column is needed, the first sealing needle sleeve can be removed.

[0069] In one embodiment of this application, such as Figure 8 and Figure 9 As shown, the dual-needle assembly 23 includes a fourth needle 231, an air filter 232, and a fifth needle 233 and a second sealing connector 234 connected in sequence. One end of the fourth needle 231 is connected to the air filter 232, and the needle seat 21 is engaged with the connector 11 so that the first needle 12 is inserted into the second sealing connector 234. In use, the other end of the fourth needle 231 and the fifth needle 233 are inserted into a bottle containing eluent, and the single-needle assembly 22 is inserted into a vacuum bottle. The fourth needle 231 connects the eluent bottle to the outside, ensuring that the pressure in the eluent bottle is always consistent with the ambient pressure. This ensures that there is always a pressure difference between the vacuum bottle and the eluent bottle, and the eluent in the eluent bottle will continuously flow into the vacuum bottle. The fourth needle 231 connects the eluent bottle to the outside through the air filter 232. The air filter 232 can effectively filter the air, delivering clean air containing bacteria and impurities into the eluent bottle. This ensures that the pressure inside the eluent bottle is always higher than that in the vacuum bottle, while preventing the eluent from being contaminated by the air.

[0070] In the embodiments of this application, a second sealing sleeve is fitted onto the fourth needle 231, and a third sealing sleeve is fitted onto the fifth needle 233. During use, the second and third sealing sleeves effectively isolate the fourth and fifth needles 231 and 233 from the external environment, preventing them from being contaminated by prolonged exposure. When the chromatography column is needed, the second and third sealing sleeves can be removed.

[0071] In one embodiment of this application, the first sealing connector 222 and the second sealing connector 234 are, for example, heparin caps. However, it should be understood that the first sealing connector 222 and the second sealing connector 234 can also be any other suitable sealing connector.

[0072] In one embodiment of this application, the first, second, and third sealing needle sleeves are, for example, soft silicone sleeves, which can more effectively isolate the needle tip from contact with the external environment. However, it should be understood that the first, second, and third sealing needle sleeves can also be any other suitable sealing structure.

[0073] In one embodiment of this application, such as Figure 10 As shown, the snap-fit ​​fixing assembly 3 includes a snap-fit ​​strip 31 and a snap-fit ​​groove 32 that cooperate with each other, one of which is disposed on the connecting seat 11 and the other on the needle seat 21. In use, the snap-fit ​​strip 31 and the snap-fit ​​groove 32 are engaged to connect the connecting seat 11 and the needle seat 21, thereby snapping the column component 1 and the needle component 2 together, achieving the connection between the needle component 2 and the column component 1. This allows only the column component 1 to enter the production process, and the needle component 2 to be snapped together with the column component 1 after production to form a color layer column, effectively preventing the needle component 2, which comes into contact with the end user, from being contaminated and carrying radioactivity.

[0074] In embodiments of this application, the snap-fit ​​strip 31 is disposed, for example, on the inner wall surface of the pin holder 21, and the snap-fit ​​groove 32 is disposed, for example, on the outer wall surface of the connector 11. However, it should be understood that the snap-fit ​​strip 31 and the snap-fit ​​groove 32 can also be disposed in any other suitable location.

[0075] In the embodiments of this application, such as Figure 10 As shown, the snap-fit ​​strip 31 is provided with a second groove 311, and the end of the snap-fit ​​strip 31 near the snap-fit ​​groove 32 is provided with an inclined surface 312. The snap-fit ​​groove 32 is provided with a protrusion 321 that matches the second groove 311. In use, the column component 1 is first transported to the production stage. After the column component 1 leaves the production stage, the snap-fit ​​strip 31 and the snap-fit ​​groove 32 are snapped together. The protrusion 321 in the snap-fit ​​groove 32 moves along the inclined surface 312 towards the second groove 311 until the protrusion 321 snaps into the second groove 311, thereby connecting the needle seat 21 and the connecting seat 11 together. This achieves the goal of only the column component 1 entering the production stage, and then snapping the needle component 2 together with the column component 1 after the production stage to form a color layer column, effectively preventing the needle component 2, which comes into contact with the user terminal, from being contaminated and carrying radioactivity.

[0076] In one embodiment of this application, the snap-fit ​​fixing assembly 3 includes a first snap and a second snap that cooperate with each other, one of which is disposed on the connecting seat 11 and the other on the needle seat 21. In use, the first snap and the second snap are snapped together, thereby securing the connecting seat 11 and the needle seat 21, allowing the needle component 2 and the column component 1 to be connected together to form a color layer column. This achieves the goal of allowing only the column component 1 to enter the production process, and then snapping the needle component 2 together with the column component 1 to form the color layer column after production, effectively preventing the needle component 2, which comes into contact with the user terminal, from being contaminated and carrying radioactivity.

[0077] In embodiments of this application, the first latch is disposed, for example, on the outer wall surface of the needle holder 21, and the second latch is disposed, for example, on the outer wall surface of the connecting seat 11. However, it should be understood that the first and second latches can also be disposed in any other suitable location.

[0078] Finally, it should be noted that the above embodiments are only used to illustrate this application and are not intended to limit this application. Although this application has been described in detail with reference to the embodiments, those skilled in the art should understand that various combinations, modifications, or equivalent substitutions of the technical solutions of this application do not depart from the spirit and scope of the technical solutions of this application and should be covered within the scope of the claims of this application.

Claims

1. A color layer column, characterized in that, include: Column components; A needle component is connected to the column component, and a snap-fit ​​fixing assembly is provided at the connection between the needle component and the column component; the column component is adapted to enter the production process separately for radioactive loading before being connected to the needle component, and then be connected to the needle component through the snap-fit ​​fixing assembly. The needle component and the column component are engaged so that the input end of the needle component, the input end of the column component, the output end of the column component, and the output end of the needle component are sequentially sealed and connected. The column component includes a connecting seat, a first needle, a second needle, and a container. The first needle and the second needle are both installed in the connecting seat. The first needle is connected to the inlet of the container, and the second needle is connected to the outlet of the container. The needle component includes a needle hub, a single needle assembly, and a double needle assembly. The single needle assembly and the double needle assembly are respectively mounted on the needle hub. The needle hub is engaged with the connecting seat so that the double needle assembly, the first needle, the container, the second needle, and the single needle assembly are sequentially sealed and connected. Both the first needle and the second needle are fitted with telescopic sealing protective sleeves, and the end of the telescopic sealing protective sleeve near the container is fixedly connected to the connecting seat; The single-needle assembly includes a third needle tip and a first sealing connector connected in sequence, and the needle seat engages with the connector so that the second needle tip is inserted into the first sealing connector; the single-needle assembly includes a first filter, and the third needle tip, the first filter, and the first sealing connector are connected in sequence. The snap-fit ​​fixing component includes at least one of the following: The locking strip and locking groove cooperate with each other, one of which is provided on the connecting seat and the other is provided on the pin seat; A first and a second latch cooperate with each other, one of which is disposed on the connecting seat and the other is disposed on the needle seat; The snap-fit ​​strip is provided with a second groove, and the end of the snap-fit ​​strip near the snap-fit ​​groove is provided with an inclined surface. The snap-fit ​​groove is provided with a protrusion that matches the second groove.

2. The color layer column according to claim 1, characterized in that, The connector engages with the needle component, thereby sealing and connecting the input end of the needle component, the first needle, the container, the second needle, and the output end of the needle component in sequence.

3. The color layer column according to claim 1, characterized in that, The column component includes a limiting and fixing block, which is mounted on the connecting seat and is used to fix the end of the telescopic sealing protective sleeve away from the container on the connecting seat.

4. The color layer column according to claim 3, characterized in that, The lower surface of the connector is provided with a plurality of locking blocks, and the limiting and fixing block is provided with a protrusion that abuts against the locking blocks. The protrusion is located between the locking blocks and the lower surface of the connector.

5. The color layer column according to claim 3 or 4, characterized in that, The connecting seat is provided with a through hole that matches the telescopic sealing protective sleeve. The side of the connecting seat away from the needle component is provided with a first groove. One end of the telescopic sealing protective sleeve passes through the through hole, and the other end of the telescopic sealing protective sleeve is located between the limiting fixing block and the first groove.

6. The color layer column according to any one of claims 1-4, characterized in that, The column component includes a first conduit and a second conduit. The side of the connector near the container is provided with a plurality of snap-fit ​​blocks that match the first conduit and the second conduit. The first conduit connects the first needle and the inlet of the container, and the second conduit connects the second needle and the outlet of the container.

7. The color layer column according to claim 6, characterized in that, The container includes a tube body, with a first connector at the upper end and a second connector at the lower end. The first conduit passes through the first connector and communicates with the tube body, and the second conduit passes through the second connector and communicates with the tube body. Both the connection points between the first connector and the tube body and the connection points between the second connector and the tube body are provided with sealing elements.

8. The color layer column according to claim 7, characterized in that, The first connector is provided with a limiting groove that matches the second conduit.

9. The color layer column according to claim 1, characterized in that, The dual-needle assembly includes a fourth needle, an air filter, and a fifth needle and a second sealing connector connected in sequence. One end of the fourth needle is connected to the air filter, and the needle seat engages with the connector seat so that the first needle is inserted into the second sealing connector.

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