A partitioned animal irradiation experiment device

Abstract

The present invention discloses a partitioned animal irradiation experiment device, which fully considers the characteristics of a point irradiation source. An irradiation box that can accommodate multiple experimental animals in the same group simultaneously is arranged around the irradiation source, ensuring that the irradiation doses received by the animals in the same group are uniform, and guaranteeing the accuracy and reliability of experimental results. The irradiation box is divided into independent compartments with different numbers by partitions with adjustable quantities. At the same time, the height of the irradiation box is adjusted by a cover plate with an adjustable position, thereby forming compartments with different heights and lengths, so as to adapt to irradiated experimental animals with different body sizes and volumes, especially applicable to both rats and mice. This device has fewer components, a simple structure, a low processing and manufacturing cost, and is very convenient for operation, adjustment, or cleaning and maintenance.

Description

Technical Field

[0001] The present invention belongs to the fields of radiation medicine and biology, and particularly relates to an animal irradiation experimental device for experimental animal research. Background Art

[0002] Exposures to environmental ionizing radiation (such as rays), radioactive isotopes (such as 60 Co), etc. can lead to the occurrence and casualties of acute radiation sickness in personnel. Studying the radiation damage mechanism of organisms and developing radiation protection drugs have great significance and application value. In addition, malignant tumor is one of the important diseases currently endangering human health and poses the most serious threat to human survival. Since the curative effect and cost-effectiveness of radiotherapy are both relatively significant, it has become a commonly used cancer treatment method, and more than 70% of tumor patients need to receive radiotherapy to varying degrees. Since radiotherapy inevitably damages normal tissues and organs while inhibiting or killing tumor cells, causing pain to patients and even leading to death, therefore, before entering human clinical trials, the mechanism of radioactive damage and the research and development of radiation protection drugs often need to be verified through animal irradiation experiments using animal models.

[0003] In animal irradiation experiments, small animals such as mice and rats are often used as experimental subjects. When conducting irradiation experiments, it is often necessary to put mice and rats of the same group or the same irradiation dose into the corresponding irradiation device for irradiation. However, due to the strong activity and poor cooperation characteristics of mice and rats, it is easy to cause the phenomenon that they move freely in the device and cannot be fixed. During radiation, the absorbed dose of mice is inversely proportional to the square of the distance. Therefore, the distance between the mice and the radiation source plays a decisive role in the radiation dose. If the distances of mice from the radiation source are not consistent, it will lead to a large error in the irradiation doses of mice within the same group, and ultimately result in unsatisfactory experimental results.

[0004] Therefore, some improvements have been made to the animal irradiation experimental device in the prior art:

[0005] For example, a Chinese utility model patent with the authorization announcement number CN201977959U discloses a mouse fixing device, which includes a base, a card slot fixedly arranged on the base, and a mouse tube. The card slot matches the mouse tube, and the mouse tube is clamped in the bayonet. The inner tube of the mouse tube can accommodate a mouse. Among them, a mouse tube cover is arranged in the mouse tube, and the mouse tube cover can slide back and forth in the mouse tube. The size of the narrow space formed by the mouse tube and the mouse tube cover can be adjusted by the different positions of the mouse tube cover in the mouse tube, that is, the mouse tube cover is fixed in the mouse tube by a latch inserted into the latch hole on the mouse tube. In this utility model, the volume adjustment of the mouse is achieved by adjusting the position of the mouse tube cover in the mouse tube. Since the volume of a rat is usually 6 to 8 times that of a mouse, not only is its body length longer, but its body shape is also larger. If only the position of the mouse tube cover is adjusted, a rat cannot be placed in the mouse tube that accommodates a mouse. Therefore, this means that this device can only be used for irradiating mice. Moreover, if this device is modified into a rat fixing device, the model of the mouse tube will be relatively large. If a mouse is to be placed in the mouse tube that accommodates a rat, the mouse cannot be fixed. Therefore, the modified device can only be used for irradiating rats. In short, the animal fixing device of this utility model cannot be compatible with rats and mice. Frequent replacement of the mouse tube not only makes the operation cumbersome, but also easily shortens the service life of the card slot; the difference in the models of different mouse tubes is large, and the card slot is also prone to failure; in addition, the fixation of each mouse in this device requires adjusting the latch back and forth, which is time-consuming.

[0006] For another example, a Chinese utility model patent with the authorization announcement number CN 204181735U discloses a fixing device for small animal irradiation experiments such as rats and mice. Its structure includes a bottom plate, and a number of parallel grooves are arranged on the bottom plate. A base that can move along the groove is arranged in each groove, and the mouse tube is arranged on the base through a fixing mechanism. An adjustable-depth tube cover is arranged in the mouse tube. Each base can be fixed at any position in its corresponding groove, and multiple bases are arranged in an arc. This utility model arranges the fixed animals in an arc shape during irradiation to ensure the uniformity of the irradiation dose. Similar to the aforementioned mouse fixing device, the volume adjustment of the mouse tube in this utility model is achieved by adjusting the position of the mouse tube cover in the mouse tube. Therefore, this device cannot be compatible with rats and mice, and different models of mouse tubes need to be frequently replaced during use, which is cumbersome. The fixing mechanism between the mouse tube and the base is prone to failure. In addition, the volume of this base is relatively large, which is inconvenient in actual operation.

[0007] For another example, a Chinese invention patent application with the publication number of CN 103565537 A discloses a mouse irradiation disc fixing device, which includes a chassis and a top cover arranged on the chassis. The chassis is a concentric circle structure composed of a circular outer edge and a circular inner edge. A plurality of partitions are arranged between the circular outer edge and the circular inner edge to divide the chassis into mouse compartments of equal size. A plurality of height-adjustable elevation cards are evenly arranged on the circular outer edge of the chassis. An oval mouse hole is provided on the top cover, and a push-pull baffle for sealing is arranged at an adjacent position to the mouse hole. By arranging a plurality of partitions on the concentric circle chassis and a plurality of elevation cards with adjustable height on the outer edge of the chassis, when the mouse is irradiated, it is arranged in a concentric circle and the body position is also the same, so as to ensure the uniformity of the irradiated dose. This application determines the internal space size of the fixing device by adjusting the height of the elevation card at one time to match the body size of the mouse and fix it firmly. Due to the accommodation space that matches the body size of the mouse and is fixed firmly, only by adjusting the height of the elevation card, it is impossible to accommodate rats. Thus, this device cannot be compatible with both rats and mice. Moreover, during the experiment, there is a chance that the mouse will escape from the elevation card. In addition, the air permeability of this device is not good, and the volume and quantity of animals used in the experiment are also limited by the characteristics of the device itself. Moreover, when using the device of this application, if all animals are to be irradiated at one time, the radiation source must be arranged above the fixing device. Generally speaking, the X-ray irradiation source can be arranged above the fixing device. However, for common point irradiation sources, for example, 137 Cs-γ rays, are usually arranged at the central position, and the animal fixing device surrounds the irradiation source, and the irradiation source cannot be arranged above the animal fixing device. Therefore, the device of this patent application is only applicable to the X-ray irradiation source and not applicable to the point irradiation source.

[0008] In summary, the existing irradiation device components are complex, the operation is cumbersome, and it can only be used for mouse irradiation experiments and cannot be well compatible with irradiation experiments on rats or other experimental animals. Summary of the Invention

[0009] In view of this, the present invention provides a partitioned animal irradiation experiment device, which adopts a point irradiation source, can be applicable to both rats and mice, can ensure that the same group of animals can receive uniform irradiation dose, and ensure the accuracy and reliability of the experimental results. The device has fewer components, a simple structure and a simple operation.

[0010] In order to achieve the above object, the present invention adopts the following technical solutions:

[0011] A partitioned animal irradiation experiment device, including: an irradiation source and an irradiation box, the radiation source is a point radiation source, wherein,

[0012] The irradiation box is a cuboid irradiation box, which is composed of left and right end faces, front and rear side walls and a bottom surface, and the top surface is open;

[0013] At different heights on the first end face (left end face or right end face) of the irradiation box, a number of horizontal cover plate entrances and exits are provided;

[0014] A number of parallel first grooves are arranged at intervals on the inner bottom surface of the irradiation box, and the first grooves are parallel to the short side of the rectangle of the bottom surface of the irradiation box;

[0015] A number of vertical second grooves are arranged at intervals on the inner walls of the front and rear side walls of the irradiation box, and the second grooves are perpendicular to the bottom surface of the irradiation box; The positions of the second grooves arranged on the front and rear side walls of the irradiation box are in one-to-one correspondence, and each group of one-to-one corresponding second grooves is vertically connected to a first groove;

[0016] A number of horizontal third grooves are arranged in parallel on the inner walls of the front and rear side walls of the irradiation box, and the positions of the third grooves arranged on the front and rear side walls of the irradiation box are in one-to-one correspondence; The height of each third groove in the vertical direction corresponds to the height of each cover plate entrance and exit;

[0017] In addition, the partitioned animal irradiation experiment device further includes:

[0018] A partition board, which is used to be inserted into the first groove and is clamped with the second grooves on both sides, so as to divide the irradiation box into several compartments, and the compartments are used to accommodate experimental animals; and

[0019] A cover plate, which is used to be inserted into the third groove through the cover plate entrance and exit to form a clamping connection, so that the irradiation box is closed; A number of groups of ventilation holes are provided on the top surface of the cover plate for air circulation.

[0020] In a specific example of the present invention, the partitioned animal irradiation experiment device further includes: The point radiation source is 137 Cs or 60 Co.

[0021] In a specific example of the present invention, the irradiation box is arranged around the irradiation source.

[0022] In a specific example of the present invention, the irradiation box is one or more.

[0023] In a specific example of the present invention, the experimental animals are rats or mice.

[0024] In a specific example of the present invention, a plurality of horizontal grooves are provided at different heights on the second end face (right end face or left end face) of the irradiation box, the number of the grooves is the same as the number of the cover plate entrances and exits, and the heights where the grooves are located correspond one-to-one to the heights where the cover plate entrances and exits are located; a first protrusion is provided at the first end of the cover plate, the first protrusion is matched with the groove, and the first protrusion is inserted into the groove to form a snap connection, so that the irradiation box is more firmly closed.

[0025] In a specific example of the present invention, the distance between any two adjacent first grooves is equal, and the distance between any two adjacent second grooves on the same side wall is equal.

[0026] In a specific example of the present invention, a second protrusion extending outward is provided on the second end face (right end face or left end face) of the irradiation box, which can be used as a handle of the irradiation box to facilitate movement and carrying.

[0027] In a specific example of the present invention, the irradiation box, the partition plate and the cover plate are all made of high-transparency polypropylene material, which is convenient for experimental animals to receive irradiation and also convenient for observing the state of experimental animals in the irradiation box.

[0028] In a specific example of the present invention, the number of the cover plate entrances and exits is two or more.

[0029] In a specific example of the present invention, the cover plate is a push-pull type cover plate.

[0030] In a specific example of the present invention, each group of the ventilation holes are evenly spaced on the top surface of the cover plate.

[0031] In a specific example of the present invention, each group of the ventilation holes includes 16 small ventilation holes and 1 large ventilation hole, and the small ventilation holes are radially distributed around the large ventilation hole.

[0032] In a specific example of the present invention, when the cover plate completely covers the irradiation box, the vertical projection of the large ventilation hole in each group of the ventilation holes on the bottom surface of the irradiation box is located at the center of the bottom surface of the smallest compartment, and the smallest compartment refers to the compartment formed by inserting two partition plates into two adjacent first grooves.

[0033] In a specific example of the present invention, the number of the partition plates is adjusted according to the body size of the experimental animals.

[0034] In a specific example of the present invention, the number of the partition plates is 11 or 2.

[0035] In a specific example of the present invention, the partition plate is provided with a mark.

[0036] In a specific example of the present invention, a mark is provided on the outer wall of the front side wall or the rear side wall of the irradiation box.

[0037] In the partitioned animal irradiation experimental device of the present invention, fully considering the characteristics of the point irradiation source, the irradiation box that can accommodate multiple experimental animals in the same group at the same time is arranged around the irradiation source, which can ensure that the irradiation doses received by the animals in the same group are uniform, and ensure the accuracy and reliability of the experimental results; the irradiation box is divided into independent compartments with different numbers by adjustable partitions, and at the same time, the height of the irradiation box is adjusted by a cover plate with an adjustable position, so that compartments with different heights and lengths can be formed, thus adapting to irradiated experimental animals with different volumes and body types, especially applicable to both rats and mice. The device has fewer components, a simple structure, low processing and manufacturing costs, and is very convenient for operation, adjustment, or cleaning and maintenance.

[0038] Compared with the prior art, the present invention has the following beneficial technical effects:

[0039] (1) In the present invention, multiple animals in the same group are fixed in the same irradiation box, ensuring the consistency of the distance between the animals and the radiation source, and thus ensuring the uniformity of the absorbed dose.

[0040] (2) By adjusting the number of inserted partitions and the position of the cover plate, animals of different volumes can be fixed in the irradiation device. Therefore, whether the irradiated animals are mice or rats, the same irradiation experimental device can be used, fully meeting the needs of different irradiation experiments.

[0041] (3) The ventilation holes provided on the top surface of the cover plate ensure the normal breathing of the animals during the experiment, greatly reducing the influence of other factors on the experiment.

[0042] (4) In the present invention, multiple animals can be fixed simultaneously in a single irradiation box at one time, for example, 12 mice or 3 rats, which can meet the simultaneous irradiation of one group or multiple groups of animals with different treatments, improving the experimental efficiency and reducing the experimental cost.

[0043] (5) The present invention has few components, a simple structure, is easy to use, the operation and adjustment are very simple, it is easy to disassemble, and it is convenient to clean. Description of the Drawings

[0044] Figure 1 is a schematic diagram of the first partitioned animal irradiation experimental device of the present invention.

[0045] Figure 2 is an exploded structural schematic diagram of the first partitioned animal irradiation experimental device of the present invention (the irradiation source is not shown).

[0046] Figure 3It is the front view of the first partitioned animal irradiation experiment device (the irradiation source is not shown) of the present invention.

[0047] Figure 4 It is the top view of the cover plate in the first partitioned animal irradiation experiment device of the present invention.

[0048] Figure 5 It is the schematic diagram of the usage state of the cover plate in the first partitioned animal irradiation experiment device of the present invention.

[0049] Figure 6A and Figure 6B It is the front view of the rat partition board and the mouse partition board in the first partitioned animal irradiation experiment device of the present invention.

[0050] Figure 7A and Figure 7B It is the schematic diagram of two states, namely, the state without the cover plate and the state with the cover plate, in the first application example of the partitioned animal irradiation experiment device of the present invention.

[0051] Figure 8A and Figure 8B It is the schematic diagram of two states, namely, the state without the cover plate and the state with the cover plate, in the second application example of the partitioned animal irradiation experiment device of the present invention. Specific embodiments

[0052] To better illustrate the present invention and facilitate understanding of its technical solutions, the present invention will be further described in detail below in conjunction with specific embodiments and the drawings. It should be understood that the following embodiments are only used to illustrate the present invention and do not represent or limit the scope of the protection of the present invention. The scope of protection of the present invention is subject to the claims.

[0053] As Figure 1 shown, a partitioned animal irradiation experiment device includes an irradiation source and an irradiation box. The irradiation source is a point irradiation source 137 Cs, which is located at the central position, and the irradiation box is arranged around the irradiation source. The irradiation box can be one or multiple.

[0054] Among them, the irradiation box is as Figure 2 and Figure 3 shown:

[0055] The irradiation box 1 is a cuboid box. The plane formed by the sides where the length and height of the cuboid are located is the front and rear side walls of the irradiation box 1. The plane formed by the sides where the width and height of the cuboid are located is the left and right end faces of the irradiation box 1. The plane formed by the sides where the length and width of the cuboid are located is the bottom and top surfaces of the irradiation box 1 (the top surface of the irradiation box 1 is open). Therefore, the irradiation box 1 is composed of the left and right end faces, the front and rear side walls, and the bottom surface, and the top surface is open;

[0056] On the first end face of the irradiation box 1 (either the left end face or the right end face is acceptable, Figure 2 here it is the right end face), several horizontal cover plate entrances and exits 7 are provided at different heights;

[0057] On the inner bottom surface of the irradiation box 1, several parallel first grooves 8 are arranged at intervals, and the first grooves 8 are parallel to the short side of the rectangle of the bottom surface of the irradiation box 1;

[0058] On the inner walls of the front and rear side walls of the irradiation box 1, several vertical second grooves 9 are arranged at intervals, and the second grooves 9 are perpendicular to the bottom surface of the irradiation box 1; the positions of the second grooves 9 provided on the front and rear side walls of the irradiation box 1 are in one-to-one correspondence (that is, the positions of the second grooves 9 provided on the front side wall of the irradiation box 1 are in one-to-one correspondence with the positions of the second grooves 9 provided on the rear side wall of the irradiation box 1), and each group of one-to-one corresponding second grooves 9 is perpendicular to and connected to one first groove 8 (that is, a certain second groove 9 on the front side wall is perpendicular to and connected to a certain first groove 8 to form a right angle, and a second groove 9 on the corresponding rear side wall is also perpendicular to and connected to the same first groove 8 to form a right angle);

[0059] On the inner walls of the front and rear side walls of the irradiation box 1, several horizontal third grooves 6 are arranged in parallel, and the positions of the third grooves 6 provided on the front and rear side walls of the irradiation box 1 are in one-to-one correspondence (that is, the positions of the third grooves 6 provided on the front side wall of the irradiation box 1 are in one-to-one correspondence with the positions of the third grooves 6 provided on the rear side wall of the irradiation box 1); multiple bayonets are formed at the intersection of each third groove 6 and the second groove 9; the height of each third groove 6 in the vertical direction corresponds to the height of the cover plate entrance and exit 7;

[0060] In addition, the above-mentioned partitioned animal irradiation experimental device further includes a partition plate 3 and a cover plate 4, wherein,

[0061] The partition plate 3, as Figure 6A or Figure 6B shown, is used to be inserted into the first groove 8 and is clamped with the second grooves 9 on both sides, so as to divide the irradiation box 1 into several compartments, and the compartments are used to accommodate experimental animals, such as rats or mice;

[0062] The cover plate 4, as Figure 4 shown, is used to be inserted into the third groove 6 through the cover plate entrance and exit 7 to form a clamping connection, so that the irradiation box 1 is closed; several groups of ventilation holes 5 are provided on the top surface of the cover plate 4 for air circulation.

[0063] It should be noted that in Figure 2 here, on the second end face of the irradiation box 1 (either the right end face or the left end face is acceptable, that is, the other end face opposite to the end face where the cover plate entrance and exit 7 is located, Figure 2On the left end face (the middle is the left end face), there are several horizontal grooves 10 at different heights. The number of grooves 10 is the same as the number of cover plate entrances and exits 7, and the positions of the grooves 10 (or the heights at which the grooves 10 are located) correspond one by one to the positions of the cover plate entrances and exits 7 (or the heights at which the cover plate entrances and exits 7 are located).

[0064] In Figure 2 and Figure 4 In, a first protrusion 11 is provided at the first end of the cover plate 4. The first protrusion 11 is used to cooperate with the groove 10. When the cover plate 4 is inserted into the third groove 6 through the cover plate entrance and exit 7 and pushed forward until the first protrusion 11 is inserted into the groove 10 to form a snap connection, the closure of the irradiation box 1 becomes more secure.

[0065] However, those skilled in the art can understand that the first protrusion 11 and the groove 10 are not necessary. The cover plate 4 can be directly inserted into the third groove 6 to achieve the closing function of the irradiation box 1. The snap connection between the first protrusion 11 and the groove 10 can make the closure of the irradiation box 1 more secure.

[0066] Similarly, in Figure 2 In, on the second end face of the irradiation box 1 (either the right end face or the left end face, which is the other end face opposite to the end face where the cover plate entrance and exit is located, Figure 2 the middle is the left end face), a second protrusion 2 extending outward is also provided, which can be used as a handle for the irradiation box 1 to facilitate movement and carrying.

[0067] Those skilled in the art can also understand that the second protrusion 2 is not necessary. There can be a protrusion as set in Figure 2 In, or the protrusion can be not provided, which does not affect the realization of the functions of the irradiation experiment device.

[0068] Those skilled in the art can understand that in the above-mentioned partitioned animal irradiation experiment device, the irradiation box 1, the partition 3, and the cover plate 4 can all be made of high-transparency polypropylene (HTPP) material, which is convenient for experimental animals to receive irradiation and also convenient for observing the state of the experimental animals in the irradiation box 1.

[0069] Those skilled in the art can understand that in the above-mentioned partitioned animal irradiation experiment device, the cover plate 4 is a push-pull type cover plate. When all the irradiated animals are placed in each compartment, the first end of the cover plate 4 is inserted from the cover plate entrance and exit 7 until the first protrusion 11 of the cover plate 4 forms a snap connection with the groove 10, and the irradiation box 1 forms a relatively enclosed space; when the irradiation experiment is completed, the cover plate 4 can be taken out by pushing it. The schematic diagram of the usage state of the cover plate 4 is as shown in Figure 5 shown.

[0070] Those skilled in the art can understand that in the above-mentioned partitioned animal irradiation experiment device, the number of the cover plate entrances and exits 7 is two or more. According to needs, the cover plate 4 can be inserted into the third groove 6 from the cover plate entrances and exits 7 at different heights, so as to form independent compartments with different volumes to meet the needs of experimental animals of different body sizes, making the device compatible with different experimental animals. Although Figure 3 only shows the situation where the cover plate 4 forms a snap connection with the third groove 6 through the cover plate entrance and exit 7 at the top to close the irradiation box 1, however, those skilled in the art can understand that the cover plate 4 can also form a snap connection with the corresponding third groove 6 at the cover plate entrance and exit 7 at other heights to close the irradiation box 1.

[0071] Moreover, those skilled in the art can understand that when there are two or more cover plate entrances and exits 7, two or more grooves 10 are provided at different heights on the second end face of the irradiation box 1. For example, when the cover plate 4 is inserted into the third groove 6 at a higher height to form a snap connection and form a closed irradiation box 1, the cover plate entrance and exit 7 and the groove 10 at a lower height can play a role in ventilation; or a matching protrusion can be selected to block the cover plate entrance and exit 7 and the groove 10 to achieve closure.

[0072] Those skilled in the art can understand that in the above-mentioned partitioned animal irradiation experiment device, each group of ventilation holes 5 are evenly spaced on the top surface of the cover plate 4 (or in other words, each group of ventilation holes 5 are equidistantly spaced on the top surface of the cover plate 4).

[0073] Furthermore, each group of ventilation holes 5 can be set as a combination of 16 small ventilation holes and 1 large ventilation hole, where the 16 small ventilation holes are radially distributed around the large ventilation hole.

[0074] Furthermore, it can also be set that when the cover plate 4 completely covers the irradiation box 1, the vertical projection of the large ventilation hole in each group of ventilation holes 5 on the bottom surface of the irradiation box 1 is located at the center of the bottom surface of the smallest compartment, where the smallest compartment refers to the compartment formed by inserting two partition plates 3 into two adjacent first grooves 8.

[0075] Those skilled in the art can understand that in the above-mentioned partitioned animal irradiation experiment device, partition plates 3 with different heights can be matched according to needs. For example, if it is a mouse, a mouse partition plate 3 with a suitable height can be selected (as shown in Figure 6B ), and inserted into the cover plate 4 from the cover plate entrance and exit 7 at the corresponding height to form a closed independent compartment; for example, if it is a rat, a rat partition plate 3 with a suitable height can be selected (as shown in Figure 6A ), and inserted into the cover plate 4 from the cover plate entrance and exit 7 at the corresponding height to form a closed independent compartment.

[0076] Those skilled in the art can understand that in the above partitioned animal irradiation experimental device, the number of partitions 3 is adjusted according to the size of the animals. For example, it can be set to 11 or 2.

[0077] Those skilled in the art can understand that in the above partitioned animal irradiation experimental device, the partition 3 can be provided with marks. For example, numerical marks can be marked on the partition 3 with a marker pen for marking animal groups. Of course, in order to achieve the marking function, such marks can also be set on the outer wall of the front side wall or the rear side wall of the irradiation box 1.

[0078] Those skilled in the art can understand that in the above partitioned animal irradiation experimental device, the distance between any two adjacent first grooves 8 is equal, and the distance between any two adjacent second grooves 9 on the same side wall is equal.

[0079] Those skilled in the art can understand that the irradiation source can also be other point irradiation sources, such as 60 Co, etc.

[0080] The preparation process of the irradiation experiment using the above experimental device is as follows:

[0081] Place the irradiation box 1 at an appropriate position from the irradiation source according to irradiation conditions such as radiation dose, dose rate, and source distance;

[0082] According to the volume of the irradiated animals, insert an appropriate number and appropriate height of partitions 3 into the first grooves 8 inside the irradiation box 1 and snap them into the second grooves 9 to form several independent compartments inside the irradiation box 1;

[0083] Put the irradiated animals into each compartment in turn, and according to the size of the irradiated animals, select a cover plate entrance and exit 7 with an appropriate height and insert the cover plate 4 into the third groove 6 at the corresponding height to form a relatively enclosed compartment. After the irradiated animals are placed, insert the first protrusion 11 of the cover plate 4 into the groove 10 at the height corresponding to the cover plate entrance and exit 7 to form a complete closed structure. Then, the animal irradiation experiment can be started.

[0084] It can be seen that in the partitioned animal irradiation experimental device of the present invention, the first grooves 8, the second grooves 9, and the inserted partitions 3 divide the irradiation box 1 into several compartments, and after inserting the cover plate 4, several closed compartments are formed.

[0085] Application Example 1

[0086] As Figure 7A and Figure 7B shown, 2 rat partitions 3 are inserted inside the irradiation box 1 to form 3 compartments. Figure 7A What is shown is the situation without covering the cover plate 4. Figure 7BShown is the situation after the cover plate 4 is covered. At this time, the cover plate 4 is inserted from the cover plate entrance and exit 7 at the top and is snap-connected to the third groove 6 at the top, so that the irradiation box 1 is formed into a closed state.

[0087] Before the experiment starts, put 1 rat into each compartment, and a total of 3 rats are put in. After putting them in, cover the cover plate 4 and irradiate; after the experiment ends, push the cover plate 4 to the right, open the irradiation box 1, take out the irradiated rats and the rat partition 3, and then the whole device can be cleaned.

[0088] Among them, the length of the irradiation box 1 (the length of the second protrusion 2 is not included) is 600 mm, and the distance between two adjacent rat partitions 3 is 200 mm; the width of the irradiation box 1 (the distance between the two outer walls of the front and rear side walls) is 110 mm, the height of the irradiation box 1 is 100.5 mm; the width of the cover plate 4 is 105 mm; the height of the partition 3 is 75.5 mm.

[0089] During the experiment, the radiation source used is a point radiation source, such as 137 Cs or 60 Co.

[0090] Application Example 2

[0091] As shown in Figure 8, 11 mouse partitions 3 are inserted inside the irradiation box 1 to form 12 compartments. Before the experiment starts, put 1 mouse into each compartment, and a total of 12 mice are put in and irradiated; after the experiment ends, push the cover plate 4 to the right, open the irradiation box 1, take out the irradiated mice and the mouse partition 3, and then the whole device can be cleaned.

[0092] During the experiment, the radiation source used is a point radiation source, such as 137 Cs or 60 Co.

[0093] In this example, the length of the irradiation box 1 (the length of the second protrusion 2 is not included) is 600 mm, and the distance between two adjacent partitions 3 is 50 mm; the width of the irradiation box 1 (the distance between the two outer walls of the front and rear side walls) is 110 mm, the height of the irradiation box 1 is 100.5 mm; the width of the cover plate 4 is 105 mm; the height of the mouse partition 3 is 35 mm.

[0094] Obviously, the same irradiation box 1 is adopted in Example 2 and Example 1, and the difference lies only in the different inserted partitions 3, including the height and quantity of the partitions 3. It can be seen that for the partitioned animal irradiation experiment device of the present invention, by simply controlling the height and quantity of the inserted partitions 3, the switching of the experimental device applicable to rats or mice can be realized, which is very convenient. Therefore, the partitioned animal irradiation experiment device of the present invention can be compatible with the irradiation experiments of rats and mice, and can also be compatible with the irradiation experiments of other experimental animals.

[0095] Therefore, in the partitioned animal irradiation experiment device of the present invention, fully considering the characteristics of the point irradiation source, the irradiation box capable of accommodating multiple experimental animals in the same group at the same time is arranged around the irradiation source, which can ensure that the irradiation doses received by the animals in the same group are uniform, and ensure the accuracy and reliability of the experimental results; the irradiation box is divided into independent compartments with different numbers by adjustable partitions, and at the same time, the height of the irradiation box is adjusted by a cover plate with an adjustable position, so that compartments with different heights and lengths can be formed, thereby adapting to irradiated experimental animals with different volumes and body sizes, especially applicable to both rats and mice. The device has fewer components, a simple structure, a low processing and manufacturing cost, and is very convenient for operation, adjustment, or cleaning and maintenance.

[0096] Thus, the object of the present invention has been fully and effectively achieved. The method and principle of the present invention have been demonstrated and illustrated in the embodiments, and the embodiments can be modified arbitrarily without departing from the principle. Therefore, the present invention includes all modified embodiments based on the spirit and scope of the claims.

Claims

1. A partitioned animal irradiation experiment device, comprising: An irradiation source and an irradiation box, the irradiation source being a point radiation source, characterized in that the irradiation box is a cuboid irradiation box, composed of left and right end faces, front and rear side walls and a bottom surface, with the top surface open; a number of horizontal cover plate entrances and exits are provided at different heights on the first end face of the irradiation box; a number of parallel first grooves are arranged at intervals on the inner bottom surface of the irradiation box, and the first grooves are parallel to the short side of the rectangle of the bottom surface of the irradiation box; a number of vertical second grooves are arranged at intervals on the inner walls of the front and rear side walls of the irradiation box, and the second grooves are perpendicular to the bottom surface of the irradiation box; the positions of the second grooves provided on the front and rear side walls of the irradiation box correspond to each other one by one, and each group of corresponding second grooves is vertically connected to a first groove; a number of horizontal third grooves are arranged in parallel on the inner walls of the front and rear side walls of the irradiation box, and the positions of the third grooves provided on the front and rear side walls of the irradiation box correspond to each other one by one; the height of each third groove in the vertical direction corresponds to the height of each cover plate entrance and exit; In addition, the partitioned animal irradiation experiment device further includes: a partition board for being inserted into the first groove and clamped with the second grooves on both sides, so as to divide the irradiation box into several compartments for accommodating experimental animals; and a cover plate for being inserted into the third groove through the cover plate entrance and exit to form a clamping connection, so that the irradiation box is closed; a number of groups of ventilation holes are provided on the top surface of the cover plate; the cover plate is a push-pull type cover plate.

2. The partitioned animal irradiation experiment device according to claim 1, characterized in that The said point radiation source is 137 Cs or 60 Co.

3. The partitioned animal irradiation experiment device according to claim 1, wherein a number of horizontal grooves are provided at different heights on the second end face of the irradiation box, the number of the grooves is the same as the number of the cover plate entrances and exits, and the heights of the grooves correspond to the heights of the cover plate entrances and exits one by one; a first protrusion is provided at the first end of the cover plate, and the first protrusion cooperates with the groove.

4. The partitioned animal irradiation experiment device according to claim 1, characterized in that, The distance between any two adjacent first grooves is equal, and the distance between any two adjacent second grooves on the same side wall is equal.

5. The partitioned animal irradiation experiment device according to claim 1, characterized in that, A second protrusion extending outward is provided on the second end face of the irradiation box.

6. The partitioned animal irradiation experiment device according to claim 1, wherein The irradiation box, the partition board and the cover plate are all made of high-transparency polypropylene material.

7. The partitioned animal irradiation experiment device according to claim 1, wherein Each group of the ventilation holes is evenly spaced on the top surface of the cover plate.

8. The partitioned animal irradiation experiment device according to claim 7, wherein, Each group of the ventilation holes includes 16 small ventilation holes and 1 large ventilation hole, and the 16 small ventilation holes are radially distributed around the large ventilation hole.

9. The partitioned animal irradiation experiment device according to claim 1, characterized in that, Marks are provided on the partition board.

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