A microvessel position detection method, device, system and storage medium

Abstract

The present invention discloses a method, device, system and storage medium for detecting the position of microvessels. The method comprises: in response to detecting a trigger instruction, based on a first preset wavelength, controlling a light source in a signal acquisition array to illuminate a detected object, and acquiring first reflected light signals respectively collected by at least two photodetectors in the signal acquisition array; wherein the light source in the signal acquisition array is linearly arranged with each photodetector; for each photodetector, when the first reflected light signal collected by the photodetector is a periodic signal, taking the component distance between the photodetector and the light source as the target component distance; based on the target component distance and the detection depth corresponding to the photodetector, determining the vascular position of the microvessels. The embodiment of the present invention solves the problem that the traditional vascular detection method cannot detect the position of microvessels, provides accurate position information of microvessels for medical operations, and can thereby reduce the incidence of iatrogenic vascular damage.

Description

Technical Field

[0001] The present invention relates to the field of medical device technology, and in particular to a microvascular position detection method, device, system and storage medium. Background Art

[0002] Iatrogenic vascular injury refers to accidental vascular injury during medical operations. Although large vessel injuries have been greatly reduced with the popularization and improvement of vascular surgery knowledge, microvascular injuries caused by misoperation are still difficult to avoid. Microvessels play an important role in the blood supply to peripheral tissues. For example, damage to microvessels that supply nerves may lead to functional damage to the nerves. Therefore, it is particularly important to determine whether microvessels exist and to find out their specific locations during medical operations in order to reduce the incidence of iatrogenic vascular injury.

[0003] Traditional blood vessel detection methods are usually used to detect the morphology of blood vessels and cannot obtain the location information of microvessels. Summary of the invention

[0004] The embodiments of the present invention provide a method, device, system and storage medium for detecting the position of microvessels to solve the problem that traditional blood vessel detection methods cannot detect the position of microvessels, provide accurate microvessel position information for medical operations, and thereby reduce the incidence of iatrogenic vascular injury.

[0005] According to an embodiment of the present invention, a method for detecting the position of microvessels is provided, the method comprising:

[0006] In response to detecting a trigger instruction, based on a first preset wavelength, a light source in a signal acquisition array is controlled to illuminate the object under test, and a first reflected light signal respectively acquired by at least two photodetectors in the signal acquisition array is acquired; wherein the light source in the signal acquisition array and each of the photodetectors are arranged linearly;

[0007] For each photodetector, when the first reflected light signal collected by the photodetector is a periodic signal, the component distance between the photodetector and the light source is used as the target component distance;

[0008] The blood vessel position of the microvessel is determined based on the target component distance and the detection depth corresponding to the photoelectric detector; wherein the detection depth represents the depth position of the signal acquisition array relative to the direction of the object being measured.

[0009] According to another embodiment of the present invention, a microvascular position detection device is provided, the device comprising:

[0010] A first reflected light signal acquisition module, configured to, in response to detecting a trigger instruction, control the light source in the signal acquisition array to illuminate the object under test based on a first preset wavelength, and acquire first reflected light signals respectively acquired by at least two photodetectors in the signal acquisition array; wherein the light source in the signal acquisition array is linearly arranged with each of the photodetectors;

[0011] a target component distance determination module, for each photoelectric detector, when the first reflected light signal collected by the photoelectric detector is a periodic signal, taking the component distance between the photoelectric detector and the light source as the target component distance;

[0012] The blood vessel position determination module is used to determine the blood vessel position of the microvessel based on the target component distance and the detection depth corresponding to the photoelectric detector; wherein the detection depth represents the depth position of the signal acquisition array relative to the direction of the object being measured.

[0013] According to another embodiment of the present invention, there is provided a microvascular position detection system, the system comprising: a signal acquisition array and a controller;

[0014] Wherein, the signal acquisition array is provided with a light source and at least two photodetectors, and the light source and the photodetectors are arranged linearly;

[0015] The controller includes at least one processor; and a memory that is communicatively connected to the at least one processor, the memory storing a computer program that can be executed by the at least one processor, and the computer program is executed by the at least one processor so that the at least one processor can execute the microvessel position detection method described in any embodiment of the present invention.

[0016] According to another embodiment of the present invention, a computer-readable storage medium is provided, wherein the computer-readable storage medium stores computer instructions, wherein the computer instructions are used to enable a processor to implement the microvessel position detection method described in any embodiment of the present invention when executed.

[0017] The technical solution of the embodiment of the present invention, in response to detecting a trigger instruction, controls the light source in the signal acquisition array to illuminate the object to be measured based on a first preset wavelength, and obtains the first reflected light signals respectively collected by at least two photodetectors in the signal acquisition array, wherein the light source in the signal acquisition array is linearly arranged with each photodetector, and for each photodetector, when the first reflected light signal collected by the photodetector is a periodic signal, the component distance between the photodetector and the light source is used as the target component distance, and the vascular position of the microvessel is determined based on the target component distance and the detection depth corresponding to the photodetector, thereby solving the problem that traditional vascular detection methods cannot detect the position of the microvessel, providing accurate microvessel position information for medical operations, and thereby reducing the incidence of iatrogenic vascular damage.

[0018] It should be understood that the contents described in this section are not intended to identify the key or important features of the embodiments of the present invention, nor are they intended to limit the scope of the present invention. Other features of the present invention will become easily understood through the following description. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0020] Figure 1 This is a flow chart of a method for detecting the position of microvessels provided in the first embodiment of the present invention;

[0021] Figure 2 A schematic diagram of the structure of a signal acquisition array provided in Embodiment 1 of the present invention;

[0022] Figure 3A A visualized schematic diagram of a blood flow pulsation signal provided in the first embodiment of the present invention;

[0023] Figure 3B A schematic diagram of the position of a blood vessel in a spatial coordinate system provided by the first embodiment of the present invention;

[0024] Figure 4 This is a flow chart of a method for detecting the position of microvessels provided in the second embodiment of the present invention;

[0025] Figure 5 A schematic diagram of the relationship between the light source detector distance and the average maximum penetration depth provided in the second embodiment of the present invention;

[0026] Figure 6A schematic diagram of the structure of a microvessel position detection device provided in Embodiment 3 of the present invention;

[0027] Figure 7 A schematic diagram of the structure of a microvascular position detection system provided by a fourth embodiment of the present invention;

[0028] Figure 8 This is a structural schematic diagram of a specific example of a microvascular position detection system provided in Embodiment 4 of the present invention. DETAILED DESCRIPTION

[0029] In order to enable those skilled in the art to better understand the scheme of the present invention, the technical scheme in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the present invention.

[0030] It should be noted that the terms "first", "second", etc. in the specification and claims of the present invention and the above-mentioned drawings are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequence. It should be understood that the data used in this way can be interchanged where appropriate, so that the embodiments of the present invention described herein can be implemented in an order other than those illustrated or described herein. In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusions, for example, a process, method, system, product or device that includes a series of steps or units is not necessarily limited to those steps or units that are clearly listed, but may include other steps or units that are not clearly listed or inherent to these processes, methods, products or devices.

[0031] Embodiment 1

[0032] Figure 1 This is a flow chart of a microvascular position detection method provided in the first embodiment of the present invention. This embodiment can be applied to the situation of finding the specific position of the blood vessels in the object under test in medical operation scenarios. The method can be executed by a microvascular position detection device. The microvascular position detection device can be implemented in the form of hardware and / or software. The microvascular position detection device can be configured in a microvascular position detection system. Figure 1 As shown, the method includes:

[0033] S110. In response to detecting a trigger instruction, based on a first preset wavelength, control a light source in a signal acquisition array to illuminate the object under test, and obtain first reflected light signals respectively collected by at least two photodetectors in the signal acquisition array.

[0034] In an optional embodiment, in response to detecting a manual operation instruction input by a user, a trigger instruction is generated, and / or, when the time length between the current moment and the last detection moment satisfies a preset detection period, a trigger instruction is generated. Exemplarily, the preset detection period may be 5 seconds or 1 minute.

[0035] Specifically, the first preset wavelength can be used to characterize the wavelength of the electromagnetic wave emitted by the light source. Exemplarily, the first preset wavelength can be 650nm, 1064nm, 700nm, 900nm, 473nm or 532nm, etc. The first preset wavelength is not limited here. In an optional embodiment, the first preset wavelength is 650nm or 1064nm. The advantage of this setting is that 650nm and 1064nm represent red light and near-infrared light, respectively. These two lights have low attenuation in tissues, which can effectively improve the maximum detection depth corresponding to the signal acquisition array, thereby widening the applicable detection range of microvascular position detection.

[0036] In this embodiment, the light source and the photodetectors in the signal acquisition array are arranged linearly. Specifically, the signal acquisition array includes a mounting plate, and at least two photodetectors can be mounted on one side of the light source or on both sides of the light source. The distance between the two components in the signal acquisition array can be the same or different. The two components can be a light source and a photodetector, or a photodetector and a photodetector.

[0037] Figure 2 This is a schematic diagram of the structure of a signal acquisition array provided in Embodiment 1 of the present invention. Figure 2 Figure A in the figure shows that at least two photodetectors are installed on one side of the light source. Figure 2 Figure B in the figure shows that at least two photodetectors are installed on both sides of the light source. Of course, the number of photodetectors on both sides of the light source can be the same or different.

[0038] The tissue composition of the object being measured is complex, and the refractive index between cells and between organelles does not match, resulting in the incident light not propagating in a straight line after entering the tissue, but rebounding multiple times to form diffuse reflection. The incident light passes through an approximately arc-shaped optical path and is reflected at a certain distance from the incident point. When the incident light passes through a blood vessel, due to the pulsation of the blood vessel, the first reflected light signal collected by the photodetector can reflect the pulsation information of the incident light passing through the tissue, which can be used to determine whether the incident light has passed through the blood vessel.

[0039] S120 . For each photodetector, when the first reflected light signal collected by the photodetector is a periodic signal, the component distance between the photodetector and the light source is used as the target component distance.

[0040] In an optional embodiment, the method further includes: for each photodetector, inputting the first reflected light signal collected by the photodetector into a preamplifier, and inputting the output amplified reflected light signal into an analog-to-digital converter; inputting the digital reflected light signal output by the analog-to-digital converter into a data processing module to obtain an output blood flow pulsation signal, and when the blood flow pulsation signal is periodic, setting the first reflected light signal to a periodic signal.

[0041] Exemplarily, the data processing module may perform filtering and / or averaging processing on the digital reflected light signal.

[0042] In an optional embodiment, the method further includes: displaying the blood flow pulsation signals corresponding to each photoelectric detector in a visual interface. Figure 3A This is a visualization diagram of a blood flow pulsation signal provided by the first embodiment of the present invention. Specifically, Figure 3A The blood flow pulsation signals corresponding to the five photodetectors are shown. Figure 3A The horizontal axis of the coordinate system is time, and the vertical axis is the signal intensity of the blood flow pulsation signal.

[0043] The advantage of this setting is that it allows medical operators to intuitively observe blood flow pulsation signals and have a certain prediction of the approximate location where microvessels may exist, thereby improving the real-time acquisition of microvessel location information during medical operations.

[0044] In an optional embodiment, the method further includes: performing similarity matching between the blood flow pulsation signal and the standard pulsation signal; if the matching rate exceeds a preset matching rate threshold, the blood flow pulsation signal is considered to be periodic.

[0045] In another optional embodiment, the method further includes: inputting the blood flow pulsation signal into a pre-trained classification model, and determining whether the blood flow pulsation signal has periodicity based on the output result. Exemplarily, the output result is yes or 1, which is used to indicate that the blood flow pulsation signal has periodicity, and the output result is no or 0, which is used to indicate that the blood flow pulsation signal does not have periodicity.

[0046] In another optional embodiment, the method further includes: determining the number of extreme values ​​in the blood flow pulsation signal based on a preset statistical duration, determining the pulsation frequency corresponding to the blood flow pulsation signal based on the number of extreme values, and if the pulsation frequency satisfies a preset frequency range, the blood flow pulsation signal is considered to have periodicity. The number of extreme values ​​may be a maximum value and a minimum value, and the preset frequency range is 60-100 per minute, for example.

[0047] In another optional embodiment, the method further includes: if the acquired parameter data meets the preset parameter conditions, the blood flow pulsation signal is considered to have periodicity. The parameter data includes at least two of the matching rate, the output result of the classification model and the pulsation frequency, and the preset parameter conditions include that the matching rate exceeds the preset matching rate threshold, the output result is an identification result indicating that the blood flow pulsation signal has periodicity, and the pulsation frequency meets the preset frequency range.

[0048] Specifically, when the first reflected light signal collected by the photoelectric detector is a periodic signal, it indicates that there are microvessels at the detection position corresponding to the current photoelectric detector.

[0049] S130 , determining the blood vessel position of the microvessel based on the target component distance and the detection depth corresponding to the photoelectric detector.

[0050] In an optional embodiment, the vascular position of the microvessel is determined based on the target component distance and the detection depth corresponding to the photodetector, including: constructing a spatial coordinate system based on the light source position corresponding to the light source in the signal acquisition array; and determining the vascular position of the microvessel in the spatial coordinate system based on the target component distance and the detection depth corresponding to the photodetector.

[0051] Specifically, the light source position corresponding to the light source in the signal acquisition array is used as the origin of the spatial coordinate system. Exemplarily, the horizontal axis of the spatial coordinate system represents the component distance between the light source and each photodetector, and the vertical axis represents the detection depth corresponding to each photodetector.

[0052] In an optional embodiment, the vascular position of the microvessel in the spatial coordinate system is determined based on the target component distance and the detection depth, including: using the target component distance as the horizontal coordinate position in the vascular position and using the detection depth as the vertical coordinate position in the vascular position.

[0053] Figure 3B This is a schematic diagram of the position of blood vessels in a spatial coordinate system provided by the first embodiment of the present invention. Specifically, Figure 3B Five photodetectors are shown, where the component distance between photodetector 1 and the light source is d1, and the component distance between the current photodetector and the previous photodetector or the next photodetector is d2. Accordingly, the component distances between the five photodetectors and the light source are d1, d1+d2, d1+2*d2, d1+3*d2, and d1+4*d2. Taking photodetector 1 as an example, the detection depth corresponding to photodetector 1 can be the minimum detection depth ( Figure 3B Point a in the middle), the middle detection depth ( Figure 3B Point b in the figure) or the maximum detection depth ( Figure 3B point c in the figure). Figure 3BTaking the detection depth as the maximum detection depth as an example, assuming that the photodetector 3 and the collected first reflected light signal are periodic signals, the blood vessel position of the microvessel includes (d1+2*d2, M3) in the spatial coordinate system.

[0054] The technical solution of this embodiment, in response to detecting a trigger instruction, controls the light source in the signal acquisition array to illuminate the object to be measured based on a first preset wavelength, and obtains the first reflected light signals respectively collected by at least two photodetectors in the signal acquisition array, wherein the light source in the signal acquisition array is linearly arranged with each photodetector, and for each photodetector, when the first reflected light signal collected by the photodetector is a periodic signal, the component distance between the photodetector and the light source is used as the target component distance, and the vascular position of the microvessel is determined based on the target component distance and the detection depth corresponding to the photodetector, thereby solving the problem that traditional vascular detection methods cannot detect the position of the microvessel, providing accurate microvessel position information for medical operations, and thereby reducing the incidence of iatrogenic vascular damage.

[0055] Embodiment 2

[0056] Figure 4 This is a flow chart of a microvascular position detection method provided by Embodiment 2 of the present invention. This embodiment further refines the above embodiment. Figure 4 As shown, the method includes:

[0057] S210. In response to detecting a trigger instruction, based on a first preset wavelength, control a light source in a signal acquisition array to illuminate the object under test, and obtain first reflected light signals respectively collected by at least two photodetectors in the signal acquisition array.

[0058] S220. Based on the second preset wavelength, control the light source in the signal acquisition array to illuminate the object under test, and obtain second reflected light signals respectively collected by at least two photodetectors in the signal acquisition array.

[0059] Specifically, the second preset wavelength is different from the first preset wavelength.

[0060] S230: For each photodetector, when the first reflected light signal collected by the photodetector is a periodic signal, the component distance between the photodetector and the light source is used as the target component distance.

[0061] S240 , determining the blood vessel position of the microvessel based on the target component distance and the detection depth corresponding to the photoelectric detector.

[0062] Based on the above embodiment, the method also includes: for each photodetector in the signal acquisition array, inputting the component distance between the light source and the photodetector into the simulation system; and using the output maximum average penetration depth as the detection depth corresponding to the photodetector.

[0063] The closer the component distance between the photodetector and the light source, the shallower the corresponding detection depth of the photodetector, but the stronger the first reflected light intensity of the collected first reflected light signal. On the contrary, the farther the component distance between the photodetector and the light source, the deeper the corresponding detection depth of the photodetector, but the weaker the first reflected light intensity of the collected first reflected light signal.

[0064] In an optional embodiment, the simulation system can be a Monte Carlo simulation system. Monte Carlo simulation processes light radiation into a photon stream in the form of particles, wherein each incident photon randomly interacts with the tissue in the body according to the law consistent with its physical behavior, such as walking, scattering and absorption, etc. By tracking and counting these random events, the migration law and related parameters of a large number of incident photons in the statistical average sense can be obtained. The Monte Carlo simulation method can be used to obtain the average maximum penetration depth of the incident light at different component distances between the light source and the photodetector.

[0065] Figure 5 A schematic diagram of the relationship between the light source detector distance and the average maximum penetration depth provided by the second embodiment of the present invention. Figure 5 It can be seen that as the component distance between the light source and the photodetector increases, the average maximum penetration depth of the photodetector increases linearly. When the distance between the light source and the photodetector is greater than 40 mm, the average maximum penetration depth of the photodetector no longer increases, and the maximum average maximum penetration depth is about 16 mm. According to the results of the simulation experiment, the design of the signal acquisition array can be guided, such as the maximum component distance between the light source and the photodetector does not exceed 40 mm, and the photodetectors are evenly distributed within the 40 mm distance range, corresponding to different average maximum penetration depths linearly.

[0066] In an optional embodiment, based on the target component distance and the detection depth, determining the blood vessel position of the microvessel in the spatial coordinate system includes: using half of the target component distance as the horizontal coordinate position of the blood vessel position, and using the detection depth as the vertical coordinate position of the blood vessel position. Taking the above example, in this embodiment, the blood vessel position of the microvessel includes

[0067] The advantage of such a setting is that the accuracy of the vascular position of the microvessels can be improved.

[0068] In another optional embodiment, the vascular position of the microvessel in the spatial coordinate system is determined based on the target component distance and the detection depth, including: determining a lateral position range based on a preset ratio range and the target component distance, determining a longitudinal position range based on a minimum detection depth and a maximum detection depth in the detection depth, and determining the vascular position of the blood vessel in the spatial coordinate system based on the lateral position range and the longitudinal position range.

[0069] In this embodiment, the detection depth corresponding to the photoelectric detector includes a minimum detection depth and a maximum detection depth, and the blood vessel position is used to characterize the distribution location area of ​​the microvessels. The preset ratio range is not limited here.

[0070] Taking the above example as an example, in this embodiment, the blood vessel positions of the microvessels include Among them, M3a represents the minimum detection depth corresponding to the photoelectric detector 3, and M3c represents the maximum detection depth corresponding to the photoelectric detector 3.

[0071] The advantage of this setting is that it can provide a specific distribution area of ​​microvessels, avoiding the need for medical operators to estimate the distribution area based on the vascular position of a single coordinate point, thereby further improving the accuracy and practicality of the vascular position of microvessels.

[0072] Based on the above embodiment, when at least two photodetectors respectively collect the first reflected light signals as periodic signals, it is determined whether there is an overlapping area between the blood vessel positions corresponding to the at least two photodetectors. If so, the coordinate position range corresponding to the overlapping area is used as the blood vessel position of the microvessel with the highest priority.

[0073] The advantage of this setting is that the probability of blood vessels existing within the coordinate position range corresponding to the overlapping area is the highest. Therefore, using the coordinate position range corresponding to the overlapping area as the vascular position of the microvessel with the highest priority can provide more accurate microvessel location information for medical operations, thereby further reducing the incidence of iatrogenic vascular injury.

[0074] S250 . For each photodetector, obtain a first reflected light intensity and a second reflected light intensity respectively corresponding to a first reflected light signal and a second reflected light signal collected by the photodetector.

[0075] Wherein, illustratively, the first reflected light intensity can be expressed as I' λ1 The second reflected light intensity can be expressed as I' λ2 Represents, wherein λ1 and λ2 represent the first preset wavelength and the second preset wavelength respectively.

[0076] S260. Determine the change in blood oxygen concentration of the object under test at a detection depth corresponding to the photodetector based on the first reflected light intensity and the second reflected light intensity.

[0077] In this embodiment, the blood oxygen concentration change includes the oxygenated hemoglobin (HbO2) concentration change and the deoxygenated hemoglobin (HHb) concentration change.

[0078] Wherein, illustratively, the first reflected light intensity and the first incident light intensity satisfy the formula:

[0079]

[0080] Wherein, illustratively, the second reflected light intensity and the second incident light intensity satisfy the formula:

[0081]

[0082] Among them, I λ1 (t) and I λ2 (t) represent the first incident light intensity and the second incident light intensity at time t, respectively. and represent the light absorption coefficients of HbO2 and HHb respectively under the first incident light of the first preset wavelength λ1, and respectively represent the light absorption coefficients of HbO2 and HHb corresponding to the second incident light of the second preset wavelength λ2, and represent the HbO2 concentration and HHb concentration at time t, respectively; r represents the component distance between the light source and the photodetector; DPF represents the weight coefficient of the component distance r, called the differential path factor; G λ1 represents the light absorption of tissues except HbO2 and HHb in the object under test under the first incident light of the first preset wavelength λ1, G λ2 It represents the light absorption of tissues except HbO2 and HHb in the object under test under the second incident light of the second preset wavelength λ2.

[0083] Among them, G λ1 and G λ2 is an unknown parameter, usually assuming that G λ1 and G λ2 It does not change with time, therefore, a formula is constructed based on the first reflected light intensity and the second reflected light intensity at the previous moment (t-1):

[0084]

[0085]

[0086] By solving the above four formulas, we can get the change in oxygenated hemoglobin concentration: and deoxyhemoglobin concentration

[0087] The technical solution of this embodiment controls the light source in the signal acquisition signal to illuminate the object under test based on a second preset wavelength, and obtains the second reflected light signal respectively collected by at least two photodetectors in the signal acquisition array, and for each photodetector, obtains the first reflected light intensity and the second reflected light intensity respectively corresponding to the first reflected light signal and the second reflected light signal collected by the photodetector, and determines the change in blood oxygen concentration of the object under test at the detection depth corresponding to the photodetector based on the first reflected light intensity and the second reflected light intensity, which solves the problem that traditional blood vessel detection methods cannot analyze changes in blood oxygen concentration, provides accurate blood oxygen concentration change information for medical operations, enriches the dimension of auxiliary information for medical operations, and helps to further reduce the incidence of iatrogenic vascular injuries.

[0088] Embodiment 3

[0089] Figure 6 This is a schematic diagram of the structure of a microvascular position detection device provided by the third embodiment of the present invention. Figure 6 As shown, the device includes: a first reflected light signal acquisition module 310, a target component distance determination module 320 and a blood vessel position determination module 330.

[0090] The first reflected light signal acquisition module 310 is used to control the light source in the signal acquisition array to illuminate the object under test based on the first preset wavelength in response to detecting the trigger instruction, and to acquire the first reflected light signal respectively collected by at least two photodetectors in the signal acquisition array; wherein the light source in the signal acquisition array and each photodetector are arranged linearly;

[0091] The target component distance determination module 320 is used for, for each photodetector, when the first reflected light signal collected by the photodetector is a periodic signal, to use the component distance between the photodetector and the light source as the target component distance;

[0092] The blood vessel position determination module 330 is used to determine the blood vessel position of the microvessel based on the target component distance and the detection depth corresponding to the photodetector; wherein the detection depth represents the depth position of the signal acquisition array relative to the direction of the object being measured.

[0093] The technical solution of this embodiment, in response to detecting a trigger instruction, controls the light source in the signal acquisition array to illuminate the object to be measured based on a first preset wavelength, and obtains the first reflected light signals respectively collected by at least two photodetectors in the signal acquisition array, wherein the light source in the signal acquisition array is linearly arranged with each photodetector, and for each photodetector, when the first reflected light signal collected by the photodetector is a periodic signal, the component distance between the photodetector and the light source is used as the target component distance, and the vascular position of the microvessel is determined based on the target component distance and the detection depth corresponding to the photodetector, thereby solving the problem that traditional vascular detection methods cannot detect the position of the microvessel, providing accurate microvessel position information for medical operations, and thereby reducing the incidence of iatrogenic vascular damage.

[0094] Based on the above embodiment, optionally, the device further includes:

[0095] A blood flow pulsation signal determination module is used for, for each photoelectric detector, inputting the first reflected light signal collected by the photoelectric detector into a preamplifier, and inputting the output amplified reflected light signal into an analog-to-digital converter;

[0096] The digital reflected light signal output by the analog-to-digital converter is input into the data processing module to obtain an output blood flow pulsation signal, and when the blood flow pulsation signal has periodicity, the first reflected light signal is set as a periodic signal.

[0097] Based on the above embodiment, optionally, the blood vessel position determination module 330 is specifically used to:

[0098] Constructing a spatial coordinate system based on the light source positions corresponding to the light sources in the signal acquisition array;

[0099] Based on the target component distance and the corresponding detection depth of the photodetector, the blood vessel position of the microvessel in the spatial coordinate system is determined.

[0100] Based on the above embodiment, optionally, the device further includes:

[0101] A detection depth determination module is used to input the component distance between the light source and the photodetector corresponding to each photodetector in the signal acquisition array into the simulation system;

[0102] The maximum average penetration depth of the output is taken as the detection depth corresponding to the photoelectric detector.

[0103] Based on the above embodiment, optionally, the device further includes:

[0104] A blood oxygen concentration change determination module is used to control the light source in the signal acquisition signal to illuminate the object under test based on the second preset wavelength, and obtain the second reflected light signal respectively collected by at least two photodetectors in the signal acquisition array;

[0105] For each photodetector, obtaining a first reflected light intensity and a second reflected light intensity respectively corresponding to a first reflected light signal and a second reflected light signal collected by the photodetector;

[0106] Based on the first reflected light intensity and the second reflected light intensity, the change in blood oxygen concentration of the object under test at the detection depth corresponding to the photodetector is determined; wherein the change in blood oxygen concentration includes the change in oxygenated hemoglobin concentration and the change in deoxygenated hemoglobin concentration.

[0107] The microvessel position detection device provided in the embodiment of the present invention can execute the microvessel position detection method provided in any embodiment of the present invention, and has the corresponding functional modules and beneficial effects of the execution method.

[0108] Embodiment 4

[0109] Figure 7 This is a schematic diagram of the structure of a microvascular position detection system provided in Embodiment 4 of the present invention. The system can provide services for the microvascular position detection method provided in the above embodiment, and can be configured with the microvascular position detection device provided in the above embodiment. The components, their connections and relationships, and their functions in the microvascular position detection system shown in the embodiment of the present invention are merely examples and are not intended to limit the implementation of the present invention described and / or required herein.

[0110] like Figure 7 As shown, the system includes: a signal acquisition array 410 and a controller 420; wherein, a light source 411 and at least two photodetectors 412 are provided on the signal acquisition array 410, and the light source 411 and each photodetector 412 are arranged linearly; the controller includes at least one processor 421 and a memory 422 which is communicatively connected to the at least one processor 421.

[0111] Specifically, the signal acquisition array 410 includes a mounting plate, and at least two photodetectors 412 can be mounted on one side of the light source 411, or on both sides of the light source 411. The distance between two components in the signal acquisition array 410 can be the same or different. The two components can be the light source 411 and the photodetector 412, or the photodetector 412 and the photodetector 412.

[0112] In an optional embodiment, the component distances between different detectors and the light source 411 are integer multiples of d. The user can customize the parameter value of d according to actual needs. The advantage of such a setting is that the regular component distance can reduce the complexity of the blood vessel position provided to the medical operator, so that the medical operator can grasp the blood vessel position of the microvessel in a timely and accurate manner.

[0113] In an optional embodiment, the light source 411 in the signal acquisition array 410 is a photodiode or a laser light source 411. When the light source 411 is a laser light source 411, the system further includes: a laser, a fiber coupler and an optical fiber. The laser is used to emit laser light, the fiber coupler is used to transmit the received laser light to the optical fiber, and the optical fiber is used to transmit the laser light to the laser light source 411.

[0114] In an optional embodiment, the core diameter of the optical fiber does not exceed 250 μm, and the photosensitive area of ​​the photodetector 412 is less than 0.25 m 2 . Exemplarily, the optical fiber, light source 411 and photodetector 412 are packaged together to form a front-end sensor. The advantage of such a configuration is that in a medical operation scenario, the spatial range in which the signal acquisition array 410 can be placed is usually relatively small, so the volume requirement for the signal acquisition array is relatively high. While ensuring the accuracy of the blood vessel position, this embodiment reduces the volume of the signal acquisition array 410 as much as possible, which can meet the volume requirement of the signal acquisition array 410 in the medical operation scenario.

[0115] In an optional embodiment, the system also includes: a preamplifier, an analog-to-digital converter and a data processing module, wherein the preamplifier is used to output an amplified reflected light signal based on the input first reflected light signal, the analog-to-digital converter is used to output a digital reflected light signal based on the input amplified reflected light signal, and the data processing module is used to output a blood flow pulsation signal based on the input digital reflected light signal.

[0116] The memory 422 stores a computer program that can be executed by at least one processor 421, and the processor 421 can perform various appropriate actions and processes according to the computer program stored in the read-only memory (ROM) or the computer program loaded from the storage unit to the random access memory (RAM). In the RAM, various programs and data required for the operation of the controller 420 can also be stored. The processor 421, ROM and RAM are connected to each other through a bus.

[0117] The processor 421 may be a variety of general and / or dedicated processing components with processing and computing capabilities. Some examples of the processor 421 include, but are not limited to, a central processing unit (CPU), a graphics processing unit (GPU), various dedicated artificial intelligence (AI) computing chips, various processors running machine learning model algorithms, a digital signal processor (DSP), and any appropriate processor, controller, microcontroller, etc. The processor 421 performs the various methods and processes described above, such as a microvascular location detection method.

[0118] Various implementations of the systems and techniques described above herein can be implemented in digital electronic circuit systems, integrated circuit systems, field programmable gate arrays (FPGAs), application specific integrated circuits (ASICs), application specific standard products (ASSPs), systems on chips (SOCs), load programmable logic devices (CPLDs), computer hardware, firmware, software, and / or combinations thereof. These various implementations can include: being implemented in one or more computer programs that can be executed and / or interpreted on a programmable system including at least one programmable processor, which can be a special purpose or general purpose programmable processor that can receive data and instructions from a storage system, at least one input device, and at least one output device, and transmit data and instructions to the storage system, the at least one input device, and the at least one output device.

[0119] Figure 8 This is a structural diagram of a specific example of a microvascular position detection system provided by Embodiment 4 of the present invention. Specifically, Figure 8 The microvascular position detection system shown includes a laser for emitting 650nm wavelength laser, a laser for emitting 1064nm wavelength laser, a transmitting mirror, a signal collection array, a fiber optic coupler, a controller, a preamplifier, an analog-to-digital converter, a data processor and a display.

[0120] The controller can be used to control the opening and closing of the shutter of any laser. Specifically, in response to detecting a trigger instruction, the controller selects a laser of any incident light wavelength and controls the shutter of the laser to open. The laser enters the optical coupler after being reflected by two reflectors, and then propagates in the optical fiber to enter the laser light source in the signal acquisition array, and the laser light source emits incident light to illuminate the object under test. At least two photodetectors in the signal acquisition array respectively collect the first reflected light signal, and each first reflected light signal passes through the preamplifier, analog-to-digital converter and data processing module in turn to obtain at least two blood flow pulsation signals output by the data processing module, and each blood flow pulsation signal is displayed in real time on the display.

[0121] The microvessel position detection system provided in this embodiment solves the problem that traditional blood vessel detection methods cannot detect the microvessel position, provides accurate microvessel position information for medical operations, and can further reduce the incidence of iatrogenic vascular injury.

[0122] Embodiment 5

[0123] Embodiment 5 of the present invention further provides a computer-readable storage medium, wherein the computer-readable storage medium stores computer instructions, and the computer instructions are used to enable a processor to execute a microvascular position detection method, the method comprising:

[0124] In response to detecting a trigger instruction, based on a first preset wavelength, a light source in a signal acquisition array is controlled to illuminate the object under test, and a first reflected light signal respectively acquired by at least two photodetectors in the signal acquisition array is acquired; wherein the light source in the signal acquisition array and each photodetector are arranged linearly;

[0125] For each photodetector, when the first reflected light signal collected by the photodetector is a periodic signal, the component distance between the photodetector and the light source is used as the target component distance;

[0126] The blood vessel position of the microvessel is determined based on the target component distance and the detection depth corresponding to the photoelectric detector; wherein the detection depth represents the depth position of the signal acquisition array relative to the direction of the object being measured.

[0127] In the context of the present invention, a computer-readable storage medium may be a tangible medium that may contain or store a computer program for use by or in combination with an instruction execution system, device or equipment. A computer-readable storage medium may include, but is not limited to, electronic, magnetic, optical, electromagnetic, infrared, or semiconductor systems, devices or equipment, or any suitable combination of the foregoing. Alternatively, a computer-readable storage medium may be a machine-readable signal medium. A more specific example of a machine-readable storage medium may include an electrical connection based on one or more lines, a portable computer disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disk read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing.

[0128] To provide interaction with a user, the systems and techniques described herein may be implemented on an electronic device having: a display device (e.g., a CRT (cathode ray tube) or LCD (liquid crystal display) monitor) for displaying information to the user; and a keyboard and a pointing device (e.g., a mouse or trackball) through which the user can provide input to the electronic device. Other types of devices may also be used to provide interaction with the user; for example, the feedback provided to the user may be any form of sensory feedback (e.g., visual feedback, auditory feedback, or tactile feedback); and input from the user may be received in any form (including acoustic input, voice input, or tactile input).

[0129] The systems and techniques described herein may be implemented in a computing system that includes backend components (e.g., as a data server), or a computing system that includes middleware components (e.g., an application server), or a computing system that includes frontend components (e.g., a user computer with a graphical user interface or a web browser through which a user can interact with implementations of the systems and techniques described herein), or a computing system that includes any combination of such backend components, middleware components, or frontend components. The components of the system may be interconnected by any form or medium of digital data communication (e.g., a communication network). Examples of communication networks include: a local area network (LAN), a wide area network (WAN), a blockchain network, and the Internet.

[0130] A computing system may include a client and a server. The client and the server are generally remote from each other and usually interact through a communication network. The client and server relationship is generated by computer programs running on the corresponding computers and having a client-server relationship with each other. The server may be a cloud server, also known as a cloud computing server or cloud host, which is a host product in the cloud computing service system to solve the defects of difficult management and weak business scalability in traditional physical hosts and VPS services.

[0131] It should be understood that the various forms of processes shown above can be used to reorder, add or delete steps. For example, the steps described in the present invention can be executed in parallel, sequentially or in different orders, as long as the desired results of the technical solution of the present invention can be achieved, and this document does not limit this.

[0132] The above specific implementations do not constitute a limitation on the protection scope of the present invention. It should be understood by those skilled in the art that various modifications, combinations, sub-combinations and substitutions can be made according to design requirements and other factors. Any modification, equivalent substitution and improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A method for detecting the position of microvessels, characterized in that: include: In response to detecting a trigger instruction, based on a first preset wavelength, a light source in a signal acquisition array is controlled to illuminate the object under test, and a first reflected light signal respectively acquired by at least two photodetectors in the signal acquisition array is acquired; wherein the light source in the signal acquisition array and each of the photodetectors are arranged linearly; For each photodetector, when the first reflected light signal collected by the photodetector is a periodic signal, the component distance between the photodetector and the light source is used as the target component distance; Determine the blood vessel position of the microvessel based on the target component distance and the detection depth corresponding to the photoelectric detector; wherein the detection depth represents the depth position of the signal acquisition array relative to the direction of the object being measured; The method of determining the vascular position of the microvessel based on the target component distance and the detection depth corresponding to the photodetector includes: constructing a spatial coordinate system based on the light source position corresponding to the light source in the signal acquisition array; and determining the vascular position of the microvessel in the spatial coordinate system based on the target component distance and the detection depth corresponding to the photodetector, wherein the origin of the spatial coordinate system is the light source position corresponding to the light source in the signal acquisition array.

2. The method according to claim 1, characterized in that The method further comprises: For each photodetector, inputting the first reflected light signal collected by the photodetector into a preamplifier, and inputting the output amplified reflected light signal into an analog-to-digital converter; The digital reflected light signal output by the analog-to-digital converter is input into a data processing module to obtain an output blood flow pulsation signal, and when the blood flow pulsation signal is periodic, the first reflected light signal is set as a periodic signal.

3. The method according to claim 1, characterized in that The method further comprises: For each photodetector in the signal acquisition array, inputting the component distance between the light source and the photodetector into a simulation system; The output maximum average penetration depth is used as the detection depth corresponding to the photoelectric detector.

4. The method according to any one of claims 1 to 3, characterized in that: The method further comprises: Based on the second preset wavelength, controlling the light source in the signal acquisition array to illuminate the object to be measured, and obtaining second reflected light signals respectively collected by at least two photodetectors in the signal acquisition array; For each photoelectric detector, obtaining a first reflected light intensity and a second reflected light intensity respectively corresponding to a first reflected light signal and a second reflected light signal collected by the photoelectric detector; Based on the first reflected light intensity and the second reflected light intensity, the change in blood oxygen concentration of the object under test at the detection depth corresponding to the photodetector is determined; wherein the change in blood oxygen concentration includes the change in oxygenated hemoglobin concentration and the change in deoxygenated hemoglobin concentration.

5. A microvascular position detection device, characterized in that: include: A first reflected light signal acquisition module, configured to, in response to detecting a trigger instruction, control the light source in the signal acquisition array to illuminate the object under test based on a first preset wavelength, and acquire first reflected light signals respectively acquired by at least two photodetectors in the signal acquisition array; wherein the light source in the signal acquisition array is linearly arranged with each of the photodetectors; a target component distance determination module, for each photoelectric detector, when the first reflected light signal collected by the photoelectric detector is a periodic signal, taking the component distance between the photoelectric detector and the light source as the target component distance; A blood vessel position determination module, used to determine the blood vessel position of the microvessel based on the target component distance and the detection depth corresponding to the photoelectric detector; wherein the detection depth represents the depth position of the signal acquisition array relative to the direction of the measured object; The blood vessel position determination module is specifically used to: construct a spatial coordinate system based on the light source position corresponding to the light source in the signal acquisition array; determine the blood vessel position of the microvessel in the spatial coordinate system based on the target component distance and the detection depth corresponding to the photodetector, wherein the origin of the spatial coordinate system is the light source position corresponding to the light source in the signal acquisition array.

6. A microvascular position detection system, characterized in that: include: signal acquisition array and controller; Wherein, the signal acquisition array is provided with a light source and at least two photodetectors, and the light source and the photodetectors are arranged linearly; The controller includes at least one processor and a memory communicatively connected to the at least one processor, the memory storing a computer program executable by the at least one processor, and the computer program is executed by the at least one processor so that the at least one processor can execute the microvessel position detection method described in any one of claims 1-4.

7. The system according to claim 6, characterized in that The system also includes: a preamplifier, an analog-to-digital converter and a data processing module, wherein the preamplifier is used to output an amplified reflected light signal based on the input first reflected light signal, the analog-to-digital converter is used to output a digital reflected light signal based on the input amplified reflected light signal, and the data processing module is used to output a blood flow pulsation signal based on the input digital reflected light signal.

8. The system according to claim 6, characterized in that The light source in the signal acquisition array is a laser light source. When the light source is a laser light source, the system further includes: a laser, a fiber coupler and an optical fiber. The laser is used to emit laser light, the fiber coupler is used to transmit the received laser light to the optical fiber, and the optical fiber is used to transmit the laser light to the laser light source.

9. A computer-readable storage medium, characterized in that: The computer-readable storage medium stores computer instructions, and the computer instructions are used to enable a processor to implement the microvascular position detection method according to any one of claims 1 to 4 when executed.

Images