A blood purification device and storage medium

Abstract

The present invention provides a blood purification device and storage medium, the blood purification device comprises a blood purifier, an arterial line, a venous line, a citrate anticoagulation branch and a calcium liquid anticoagulation branch, the arterial line is connected to the blood input end of the blood purifier, the venous line is connected to the blood output end of the blood purifier, the citrate anticoagulation branch is connected to the arterial line, the calcium liquid anticoagulation branch is connected to the venous line, and further comprises: a citrate adjustment module, which determines the citrate adjustment mode of the blood purification device according to the selection instruction output by the user; a citrate branch control module, which is used to control the citrate anticoagulation branch to output citrate to the arterial line according to the citrate adjustment mode, and a calcium liquid branch control module, which is used to control the calcium liquid anticoagulation branch to output calcium liquid to the venous line according to the citrate adjustment mode. The present invention solves the problem that the anticoagulation control mode of citrate in the existing blood purification device is single and cannot be generally applied to all medical staff.

Description

Technical Field

[0001] The present invention relates to the technical field of blood purification, and in particular to a blood purification device and a storage medium. Background Art

[0002] Blood purification equipment draws human blood out of the body, then filters out specific molecular substances in the blood, and then returns the purified blood to the human body to achieve the effect of disease treatment. Blood purification treatment methods can be divided into hemodialysis, hemofiltration, hemodiafiltration, hemoperfusion, plasma exchange, immunoadsorption, peritoneal dialysis and other treatment modes according to the principle of blood purification. Different blood purification treatment modes are suitable for different patients.

[0003] Blood purification therapy needs to rely on blood purification equipment to be performed, among which the most common blood purification equipment is CRRT (Continuous Renal Replacement Therapy) machine. When the CRRT machine performs blood purification therapy, the patient's blood is drawn out of the body, and the contact between the blood and the inner wall of the extracorporeal circulation circuit can trigger the body's coagulation mechanism, thereby forming a thrombus blockage. In severe cases, the coagulation phenomenon in the circuit will endanger the patient's life safety. Therefore, extracorporeal anticoagulation is an indispensable part of the blood purification treatment process. During the operation of the CRRT machine, anticoagulants need to be added to the extracorporeal circulation circuit in a timely manner to achieve anticoagulation operation. Commonly used anticoagulants include citric acid and heparin. Taking citric acid as an anticoagulant as an example, the basic principle of citric acid anticoagulants is: when human blood is drawn out of the body, citric acid is continuously infused. Citric acid can chelate calcium ions, which are an indispensable key factor in the coagulation reaction process. Citric acid can chelate with calcium ions in the blood to form a difficult-to-dissociate soluble complex calcium citrate, which reduces the calcium ions in the blood, thereby blocking the coagulation reaction at multiple levels and achieving the anticoagulant effect. Before the purified blood is returned to the human body, it is necessary to supplement the purified blood with a calcium ion solution (referred to as calcium solution) so that the blood returned to the human body can reach the normal level of the human body and restore the human body's coagulation mechanism. During blood purification treatment, medical staff need to maintain a balance between citrate and calcium solution in a timely manner. For example, when the calcium solution is supplied too quickly, the calcium ion concentration in the blood returned to the human body will be too high, causing hypercalcemia in the patient. Another example is that when the calcium ion solution is supplied too slowly, it cannot make up for the calcium lost during the citrate anticoagulation process, causing hypocalcemia in the patient. Maintaining a balanced supply of citrate and calcium solution on the CRRT machine is extremely important for the safety of the patient's blood purification treatment.

[0004] However, the existing CRRT machine has a very simple citrate anticoagulation control mode, which is very dependent on the clinical experience of medical staff. Medical staff with rich clinical experience can control the balanced supply of citrate and calcium solution. For medical staff with insufficient clinical experience, it is difficult to independently control the balanced supply of citrate and calcium solution on the CRRT machine. If the citrate anticoagulation control mode is set to be more complicated on the CRRT machine, it will be beneficial to medical staff with insufficient clinical experience and can reduce the probability of errors in the citrate anticoagulation control step. However, for medical staff with rich clinical experience, the operation is not flexible. If the citrate anticoagulation control mode is set to be more simplified on the CRRT machine, it will be beneficial to medical staff with rich clinical experience for convenient control and simplify the citrate anticoagulation control step. However, for medical staff with insufficient clinical experience, it is easy to make mistakes in the citrate anticoagulation control step, thereby damaging the safety of the patient's blood purification treatment. Summary of the invention

[0005] The present invention aims to solve the problem that the anticoagulation control mode of citric acid in the existing blood purification equipment is single and cannot be universally applied to medical staff with different clinical experience.

[0006] To solve the above problems, the first aspect of the present invention provides a blood purification device, including a blood purifier, an arterial line, a venous line, a citrate anticoagulation branch and a calcium liquid anticoagulation branch, wherein the arterial line is connected to the blood input end of the blood purifier, the venous line is connected to the blood output end of the blood purifier, the citrate anticoagulation branch is connected to the arterial line, the calcium liquid anticoagulation branch is connected to the venous line, and further includes:

[0007] The citric acid regulating module determines the citric acid regulating mode of the blood purification device according to the selection instruction output by the user, wherein the citric acid regulating mode includes a proportional mode and a speed mode. In the proportional mode, the ratio of the citric acid flow rate of the citric acid anticoagulation branch to the blood flow rate of the arterial line, and the ratio of the calcium liquid flow rate of the calcium liquid anticoagulation branch to the citric acid flow rate of the citric acid anticoagulation branch are both constant values; in the speed mode, the citric acid flow rate of the citric acid anticoagulation branch and the calcium liquid flow rate of the calcium liquid anticoagulation branch are both constant values;

[0008] a citrate branch control module, used for controlling the citrate anticoagulation branch to output the citrate to the arterial line according to the citrate regulation mode,

[0009] The calcium solution branch control module is used to control the calcium solution anticoagulation branch to output the calcium solution to the venous line according to the citric acid regulation method.

[0010] A second aspect of the present invention further provides a computer-readable storage medium having a computer program stored thereon, which implements the following method when executed by a processor:

[0011] According to the selection instruction output by the user, the citric acid regulation mode of the blood purification device is determined, wherein the citric acid regulation mode includes a proportional mode and a speed mode, in which in the proportional mode, the ratio of the citric acid flow rate of the citric acid anticoagulation branch to the blood flow rate of the arterial line, and the ratio of the calcium liquid flow rate of the calcium liquid anticoagulation branch to the citric acid flow rate of the citric acid anticoagulation branch are both constant values; in the speed mode, the citric acid flow rate of the citric acid anticoagulation branch and the calcium liquid flow rate of the calcium liquid anticoagulation branch are both constant values;

[0012] According to the citrate regulation mode, the citrate anticoagulation branch is controlled to output the citrate to the arterial line,

[0013] According to the citric acid regulation method, the calcium solution anticoagulation branch is controlled to output the calcium solution to the venous line.

[0014] The blood purification equipment, electronic equipment and storage medium provided by the present invention are provided with a citric acid adjustment module. When adjusting the citric acid, the medical staff can select the proportional mode or the speed mode. In the proportional mode, the medical staff can conveniently select the citric acid flow of the citric acid anticoagulation branch and the calcium liquid flow of the calcium liquid anticoagulation branch in a ratio manner, so that the citric acid flow, the calcium liquid flow and the blood flow of the arterial line can be kept matched. The proportional mode is suitable for some medical staff who lack clinical technical experience; in the speed mode, the medical staff can set the citric acid flow and the calcium liquid flow at will, and the setting flexibility is high. The speed mode is suitable for some medical staff with rich clinical experience; in the blood purification equipment provided by this embodiment, the medical staff can select the proportional mode or the speed mode according to their own operating habits, which brings a better use experience to the medical staff, and the blood purification equipment provided by this embodiment improves the safety of blood purification treatment of the blood purifier during the citrate anticoagulation control process, and the blood purification equipment has a higher scope of application. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 This is a schematic diagram of the first structure of a blood purification device provided in an embodiment of the present invention;

[0016] Figure 2 A schematic diagram of the structure of a display screen provided in an embodiment of the present invention;

[0017] Figure 3 A schematic diagram of information displayed on a display screen provided in an embodiment of the present invention;

[0018] Figure 4 A second structural schematic diagram of the blood purification device provided in an embodiment of the present invention;

[0019] Figure 5 This is a schematic diagram of the third structure of the blood purification device provided in an embodiment of the present invention.

[0020] Description of reference numerals:

[0021] 10-arterial line; 20-venous line; 30-blood purifier; 40-blood pump; 50-venous pot; 60-citrate anticoagulation branch; 70-calcium solution anticoagulation branch; 80-bubble detector; 90-blood detector; 11-third branch; 12-fourth branch; 21-first branch; 22-second branch; 51-liquid level detector. DETAILED DESCRIPTION

[0022] The technical solution of the present application and how the technical solution of the present application solves the above-mentioned technical problems are described in detail below with specific embodiments. The following specific embodiments can be combined with each other, and the same or similar concepts or processes may not be repeated in some embodiments. The embodiments of the present application will be described below in conjunction with the accompanying drawings.

[0023] It should be noted that examples of embodiments of the present application are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present application, and cannot be interpreted as limiting the present application.

[0024] It will be understood by those skilled in the art that, unless expressly stated, the singular forms "one", "an" and "the" used herein may also include plural forms. It should be further understood that the term "comprising" used in the specification of the present application refers to the presence of features, integers, steps, operations, elements and / or components, but does not exclude the presence or addition of one or more other features, integers, steps, operations, elements, components and / or groups thereof. It should be understood that when we refer to an element as being "connected" or "coupled" to another element, it may be directly connected or coupled to the other element, or there may be an intermediate element. In addition, the "connection" or "coupling" used herein may include wireless connection or wireless coupling. The term "and / or" used herein includes all or any unit and all combinations of one or more associated listed items.

[0025] Continuous renal replacement therapy (CRRT), also known as continuous blood purification, is a long-term, continuous extracorporeal blood purification therapy to replace damaged renal function. The blood purification treatment time of CRRT can be as long as 10 to 24 hours. Specifically, the patient's blood is led to the extracorporeal circulation circuit and certain pathogenic substances are removed through the purification device to achieve the purpose of treating the disease. CRRT has been widely used in the treatment of acute and chronic renal failure, multiple organ dysfunction syndrome, hepatic encephalopathy, drug poisoning, poison poisoning and critical illness, and has also achieved significant therapeutic effects abroad. In response to different clinical treatment needs, CRRT includes different blood treatment modes, such as: continuous veno-venous hemofiltration (CVVH), continuous veno-venous hemodialysis (CVVHD), continuous veno-venous hemodiafiltration (CVVHDF), slow continuous ultrafiltration (SCUF), continuous plasma filtration adsorption (CPFA), plasma exchange (PE), double plasma exchange (DFPP), double plasmamolecular adsorption system (DPMAS), plasma adsorption (PA), plasma dialysis filtration (PDF), hemoperfusion (HP) and other treatment modes.

[0026] In order to better illustrate the embodiments of the present application, the structure of the blood purification device is first introduced.

[0027] See also Figure 1 , Figure 1It is a structural schematic diagram of an embodiment of a blood purification device in an embodiment of the present application, and the blood purification device includes: an arterial line 10, a venous line 20, a blood purifier 30, a blood pump 40, a venous pot 50, a citrate anticoagulation branch 60, a calcium solution anticoagulation branch 70, a bubble detector 80, a blood detector 90 and a liquid level detector 51, wherein the arterial line 10 is connected to the blood input end of the blood purifier 30, and the venous line 20 is connected to the blood output end of the blood purifier 30. The arterial line 10 transmits the human body's blood to the blood input end of the blood purifier 30, and the blood purifier 30 purifies the human body's blood. The venous line 20 returns the purified blood to the human body, and the operating speed and direction of the blood pump 40 can be controlled to change the flow rate and direction of the blood in the arterial line 10.

[0028] When human blood is drawn into the pipeline (the pipeline may include the arterial pipeline 10 and the venous pipeline 20), the human blood will have the problem of coagulation without anticoagulation, so it is necessary to transport anticoagulants such as citric acid into the arterial pipeline 10 to play an anticoagulant role on the blood in the pipeline. The citric acid anticoagulation branch 60 is connected to the arterial pipeline 10. During the blood purification process of the blood purifier 30, the citric acid anticoagulation branch 60 will output citric acid to the arterial pipeline 10, and the citric acid flows with the blood in the arterial pipeline 10, the blood purifier 30, and the venous pipeline 20 to play an anticoagulant role; the calcium liquid anticoagulation branch 70 is connected to the venous pipeline 20, and the calcium liquid anticoagulation branch 70 will output calcium liquid to the venous pipeline 20 to make up for the loss of calcium ions caused by the citric acid anticoagulation process.

[0029] It should be noted that Figure 1 Only the most basic schematic diagram of the blood purification equipment is shown. Figure 1 Only some necessary components of blood purification are shown: arterial line 10, venous line 20, blood purifier 30, blood pump 40, venous pot 50, citrate anticoagulation branch 60 and calcium solution anticoagulation branch 70, etc. When the blood purification equipment is used in different blood purification treatment modes, Figure 1 On the basis of, it is expanded into the control principle diagram of various blood purification equipment. Moreover, in different blood purification treatment modes, the blood purifier 30 can be of different types: for example, in the hemodialysis treatment mode, the blood purifier 30 is a dialyzer; in the hemoperfusion treatment mode, the blood purifier 30 is a hemoperfusion device; in the plasma exchange treatment mode, the blood purifier 30 is a plasma separator, and so on.

[0030] See also Figure 5 The blood purification device provided in the embodiment of the present application further includes a citric acid regulating module, a citric acid branch control module and a calcium solution branch control module, wherein:

[0031] The citric acid regulation module is used to determine the citric acid regulation mode of the blood purification equipment according to the selection instruction output by the user, wherein the citric acid regulation mode includes a proportional mode and a speed mode. In the proportional mode, the ratio of the citric acid flow rate of the citric acid anticoagulation branch and the blood flow rate of the arterial line, as well as the ratio of the calcium liquid flow rate of the calcium liquid anticoagulation branch and the citric acid flow rate of the citric acid anticoagulation branch are both constant values; in the speed mode, the citric acid flow rate of the citric acid anticoagulation branch and the calcium liquid flow rate of the calcium liquid anticoagulation branch are both constant values.

[0032] Before blood purification treatment, a blood purification treatment mode will be selected according to the patient's treatment needs. Each blood purification treatment mode has specific clinical indications. For example, the PE treatment mode is suitable for patients with liver failure, especially those with combined coagulation dysfunction; the PDF treatment mode is suitable for the treatment of water and sodium retention in patients with end-stage renal failure or severe edema caused by various reasons. Therefore, before starting blood purification treatment, it is necessary to select a suitable blood purification treatment mode according to the patient's treatment needs in order to achieve the best blood purification treatment effect.

[0033] After selecting the blood purification treatment mode, Figure 1 For example, according to the blood purification instruction output by the user, the blood purification treatment mode of the blood purification device is selected, and in the selected blood purification treatment mode, the blood purifier is controlled to purify the patient's blood, wherein the blood purification device controls the blood pump 40 to start, the arterial line 10 outputs the blood to the blood purifier 30, and the venous line 20 returns the purified blood to the patient's body, the citrate anticoagulation branch 60 is connected to the arterial line 10, and outputs citric acid to the arterial line 10, and the citric acid flows with the blood in the arterial line 10, the blood purifier 30, and the venous line 20 to play an anticoagulant role; the calcium liquid anticoagulation branch 70 is connected to the venous line 20, and the calcium liquid anticoagulation branch 70 will output calcium liquid to the venous line 20 to make up for the loss of calcium ions caused by the citrate anticoagulation process, thereby officially starting the patient's blood purification treatment process.

[0034] When the blood purifier purifies the patient's blood, the citrate adjustment mode of the blood purification device can be set on the citrate adjustment module according to the selection instruction output by the user.

[0035] Specifically, the citrate adjustment mode includes a proportional mode and a speed mode, wherein the proportional mode is suitable for users with little clinical experience. In the proportional mode, the user can control the citrate anticoagulation process by a ratio method. In the proportional mode, the citrate flow of the citrate anticoagulation branch and the blood flow of the arterial line always present a certain ratio relationship, and the calcium liquid flow of the calcium liquid anticoagulation branch and the citrate flow of the citrate anticoagulation branch also always present a certain ratio relationship. In the proportional mode, even if the user lacks clinical experience and does not know what the reasonable values ​​of the citrate flow and the calcium liquid flow are, the user only needs to set the ratio to complete the setting of the citrate flow and the calcium liquid flow. However, the proportional mode lacks flexibility, and users cannot set the citrate flow rate and the calcium solution flow rate at will. For example, for users with rich clinical experience, the users know the reasonable values ​​of the citrate flow rate and the calcium solution flow rate. The users must first set the ratio of the citrate flow rate of the citrate anticoagulation branch to the blood flow rate of the arterial line, and then set the ratio of the calcium solution flow rate of the calcium solution anticoagulation branch to the citrate flow rate of the citrate anticoagulation branch. For users with rich clinical experience, this setting method is very troublesome, and the users cannot directly set the citrate flow rate and the calcium solution flow rate, which brings great inconvenience to the users' citrate anticoagulation control process.

[0036] The speed mode is suitable for users with rich clinical experience. When the user knows the most reasonable values ​​of the citrate flow rate and the calcium solution flow rate, the user can directly set the citrate flow rate of the citrate anticoagulation branch and the calcium solution flow rate of the calcium solution anticoagulation branch by outputting the speed setting instruction. This gives the user great control autonomy and high flexibility, and simplifies the citrate anticoagulation control steps. However, the speed mode is not suitable for users with little clinical experience. Users with little clinical experience do not know the most reasonable values ​​of the citrate flow rate and the calcium solution flow rate. It is easy for the user to set the citrate flow rate and the calcium solution flow rate incorrectly. For example, setting the citrate flow rate and / or the calcium solution flow rate too high or too low will damage the safety of the patient's citrate anticoagulation control process.

[0037] This embodiment can select a proportional mode or a speed mode according to the selection instruction input by the user. For example, the proportional mode can be selected for users with little clinical experience, and the speed mode can be selected for users with very rich clinical experience. Users can choose an appropriate mode based on their own circumstances, thereby improving the compatibility and applicability of the citrate anticoagulation control process.

[0038] In order to facilitate user operation, the blood purification device also includes a display screen. Figure 2 Schematic diagram of the structure of the display screen. By way of example, the display screen in this embodiment is a touch screen. The touch screen has an information display function and can also receive selection instructions output by a user to facilitate the citrate anticoagulation control process.

[0039] As an optional implementation, the blood purification device can recommend a citrate adjustment method according to the blood purification treatment mode, and display the recommended citrate adjustment method on the display screen;

[0040] If the selection instruction output by the user confirms the recommended citrate adjustment method on the display screen, the recommended citrate adjustment method is set as the citrate adjustment method of the blood purification device;

[0041] If the selection instruction input by the user cancels the recommended citrate adjustment method on the display screen, the citrate adjustment method of the blood purification device is reset according to the selection instruction input by the user.

[0042] Specifically, combined Figure 3 The above operation is described by way of example. Figure 3 If the blood purification treatment mode of the blood purification device selected by the blood purification instruction output by the user is the slow continuous ultrafiltration treatment mode, the display screen will display: speed mode, that is, the speed mode is the recommended citrate adjustment mode. When the selection instruction output by the user triggers the "Confirm" label on the display screen, the speed mode is set to the citrate adjustment mode of the blood purification device, and the blood purification device is subjected to the citrate anticoagulation control process in the speed mode; when the selection instruction output by the user triggers the "Cancel" label on the display screen, the citrate adjustment mode of the blood purification device is reset according to the selection instruction output by the user, and the reset citrate adjustment mode is: proportional mode. Through the display screen, users can easily select proportional mode or speed mode, which simplifies the citrate anticoagulation control steps of the blood purification device.

[0043] Since the blood purification equipment can realize a variety of blood purification treatment modes, each blood purification treatment mode corresponds to a most suitable citrate adjustment method. This correspondence is obtained based on the clinical experience summarized by technicians. Technicians in this field can display the recommended citrate adjustment method on the display screen according to different blood purification treatment modes. For example: the pipeline structure of the slow continuous ultrafiltration treatment mode is relatively simple, and the speed mode is recommended; the pipeline structure of the double plasma exchange treatment mode is relatively complex, and the blood purifier includes a plasma separator and a plasma component separator, and the proportional mode is recommended.

[0044] It should be noted that the recommended citric acid adjustment method displayed on the display screen in this embodiment is only recommended and suggested, and does not mean that only the recommended citric acid adjustment method can be adopted in the selected blood purification treatment mode. The user can confirm or cancel the recommended citric acid adjustment method on the display screen according to his or her own operating experience or habits; in addition, the recommended citric acid adjustment method displayed on the display screen is equivalent to the initial setting value of the blood purification equipment. By displaying the recommended citric acid adjustment method on the display screen, it can also serve as an operating guide and prevent users from operating the blood purification equipment for the first time and not knowing how to select the citric acid adjustment method of the blood purification equipment.

[0045] After determining the citrate adjustment mode of the blood purification equipment, the citrate branch control module can control the citrate anticoagulation branch to output citrate to the arterial line according to the citrate adjustment mode; the calcium liquid branch control module can control the calcium liquid anticoagulation branch to output calcium liquid to the venous line according to the citrate adjustment mode.

[0046] Specifically, as an optional implementation, the citric acid regulation mode of the blood purification device is set to a proportional mode, and the blood purification device further includes a first detection module, which is used to detect the blood flow of the arterial line;

[0047] Determining the blood flow of the arterial line according to the detection value of the first detection module;

[0048] Determine a first flow ratio according to a first ratio instruction output by a user, wherein the first flow ratio is a ratio between a citrate flow of the citrate anticoagulation branch and a blood flow of the arterial line;

[0049] The output flow rate of citric acid is calculated according to the blood flow rate of the arterial line and the first flow rate ratio;

[0050] The citrate branch control module controls the citrate anticoagulation branch to output citrate to the arterial line according to the output flow of citrate;

[0051] Determine a second flow ratio according to a second ratio instruction output by the user; wherein the second flow ratio is a ratio between the calcium liquid flow of the calcium liquid anticoagulation branch and the citric acid flow of the citric acid anticoagulation branch;

[0052] The calcium solution flow rate is calculated based on the output flow rate of citric acid and the ratio of the second flow rate;

[0053] The calcium liquid branch control module controls the calcium liquid anticoagulation branch to output the calcium liquid to the venous line according to the calcium liquid flow rate.

[0054] Based on the above embodiment, the user can select the first flow ratio within the preset range of the first flow ratio. In order to facilitate the user to determine the first flow ratio, as an optional implementation mode,

[0055] Displaying a first flow ratio preset range on a display screen, the first flow ratio preset range being a ratio range between a citrate flow of the citrate anticoagulation branch and a blood flow of the arterial line, the first flow ratio preset range being 0.01 to 0.25;

[0056] According to the first ratio instruction output by the user, a first flow ratio is determined within a first flow ratio preset range.

[0057] Specifically, in the proportional mode, the preset range of the first flow ratio between the citrate flow of the citrate anticoagulation branch and the blood flow of the arterial line represents: the normal matching relationship between the citrate flow of the citrate anticoagulation branch and the blood flow of the arterial line. Only when the first flow ratio is within the preset range of the first flow ratio, can the citrate be output to the arterial line through the citrate anticoagulation branch to achieve better blood anticoagulation function. The user selects a specific ratio within the preset range of the first flow ratio as the first flow ratio between the citrate flow of the citrate anticoagulation branch and the blood flow of the arterial line, which can ensure the safety of the citrate anticoagulation control process and avoid the problem of unreasonable settings of the citrate flow and blood flow.

[0058] The technicians in this field determine the preset range of the first flow ratio based on clinical technical experience. In the embodiment of the present application, the preset range of the first flow ratio is 0.01 to 0.25.

[0059] Since the blood purification equipment can realize a variety of blood purification treatment modes, in order to better match different blood purification treatment modes, the first flow ratio preset range can be set according to different blood purification treatment modes, so that the first flow ratio preset range can be set more accurately, thereby ensuring the blood anticoagulation effect during the blood purification treatment and avoiding the waste of citric acid.

[0060] Based on the above embodiment, as an optional implementation, the blood purification device further includes a second detection module, which is used to detect whether the blood purification device has a waste liquid branch and / or a plasma branch during the blood purification process;

[0061] If the second detection module detects that there is no waste liquid branch and plasma branch in the blood purification device, the preset range of the first flow ratio is 0.01 to 0.1;

[0062] If the second detection module detects that there is a waste liquid branch or a plasma branch in the blood purification device, the first flow ratio is preset in the range of 0.1 to 0.2;

[0063] If the second detection module detects that there is a waste liquid branch and a plasma branch in the blood purification device, the preset range of the first flow ratio is 0.2 to 0.25.

[0064] Among them, the waste liquid branch is used to output the waste liquid generated by the blood purifier to the waste liquid bag, and the plasma branch is used to return the plasma separated by the blood purifier to the venous line. Although blood purification equipment can achieve a variety of blood purification treatment modes, all blood purification equipment can be divided into the following four categories:

[0065] (1) The blood purification equipment does not include a waste liquid branch and a plasma branch; for example, the blood purification equipment in the blood perfusion treatment mode includes neither a plasma branch nor a waste liquid branch; (2) The blood purification equipment only includes a plasma branch; for example, the blood purification equipment in the dual plasma molecular adsorption system treatment mode only includes a plasma branch; (3) The blood purification equipment only includes a waste liquid branch; for example, the blood purification equipment in the blood filtration treatment mode only includes a waste liquid branch; (4) The blood purification equipment includes a waste liquid branch and a plasma branch, for example, the blood purification equipment in the dual plasma exchange treatment mode includes a waste liquid branch and a plasma branch.

[0066] In the first type, that is, the blood purification device does not have a waste liquid branch and a plasma branch, the pipeline structure of the blood purification device in this case is relatively simple, and the citric acid flow rate of the citric acid anticoagulation branch can be set lower to save the amount of citric acid used. Preferably, in this mode, the first flow ratio is preset in the range of 0.01 to 0.1;

[0067] In the second type, that is, there is a waste liquid branch or a plasma branch in the blood purification device, in this case, the citrate flow rate of the citrate anticoagulation branch can be set in a moderate range. Preferably, in this mode, the first flow ratio is preset in the range of 0.1 to 0.2;

[0068] In the third type, that is, the blood purification equipment has a waste liquid branch and a plasma branch, the piping structure of the blood purification equipment in this case is more complicated, and the citric acid flow rate of the citric acid anticoagulation branch needs to be set higher to ensure the blood anticoagulation effect during the blood purification treatment and prevent insufficient blood anticoagulation during the blood purification treatment. Preferably, in this mode, the first flow ratio preset range is 0.2 to 0.25.

[0069] Based on the above embodiment, the user can also select the second flow ratio within the second flow ratio preset range. In order to facilitate the user to determine the second flow ratio, as an optional implementation,

[0070] Displaying a second flow ratio preset range on a display screen, the second flow ratio preset range being a ratio range between the calcium liquid flow of the calcium liquid anticoagulation branch and the citric acid flow of the citric acid anticoagulation branch;

[0071] According to the second ratio instruction output by the user, a second flow ratio is determined within a second flow ratio preset range.

[0072] Specifically, in the proportional mode, the preset range of the second flow ratio between the calcium liquid flow of the calcium liquid anticoagulation branch and the citric acid flow of the citrate anticoagulation branch represents: the normal balance relationship between the calcium liquid flow of the calcium liquid anticoagulation branch and the citric acid flow of the citrate anticoagulation branch. Only when the second flow ratio is within the preset range, the calcium liquid anticoagulation branch outputs calcium liquid to the venous line. The calcium ions in the calcium liquid can just make up for the calcium ions lost in the blood during the citrate anticoagulation process to prevent the patient from developing hypercalcemia or hypocalcemia. The calcium liquid output by the calcium liquid anticoagulation branch has higher safety and applicability.

[0073] It should be noted that those skilled in the art can pre-set the preset range of the second flow ratio based on clinical experience, and this embodiment does not further limit this. For example, the preset range of the second flow ratio is 0.2 to 0.33.

[0074] When the user sets the first flow ratio and the second flow ratio, this embodiment will pre-set the first flow ratio preset range between the citrate flow of the citrate anticoagulation branch and the blood flow of the arterial line according to the clinical technical experience of the technician, and pre-set the second flow ratio preset range between the calcium liquid flow of the calcium liquid anticoagulation branch and the citrate flow of the citrate anticoagulation branch. The user can only select the first flow ratio within the first flow ratio preset range and the second flow ratio within the second flow ratio preset range. This ensures that during the citrate anticoagulation control process, the citrate flow and the blood flow can be matched, the calcium liquid flow and the citrate flow can be balanced, and the user operation is easier during the citrate anticoagulation control process.

[0075] On the basis of the above embodiment, as an optional implementation mode, the citric acid regulation mode of the blood purification equipment is set to a proportional mode. After determining the blood flow of the arterial line according to the first detection module, and determining the first flow ratio according to the first proportional instruction output by the user, the output flow of citric acid can be calculated according to the blood flow of the arterial line and the first flow ratio. After obtaining the output flow of citric acid, the maximum output time of the citric acid anticoagulation branch can also be set according to the output flow of citric acid.

[0076] The blood purification device also includes: a time detection module and a judgment module, the time detection module is used to detect the time for the citrate anticoagulation branch to continuously output citrate;

[0077] The judgment module is used to judge whether the time for which the citrate anticoagulation branch continuously outputs citric acid is greater than or equal to the maximum output time of the citrate anticoagulation branch. If the time for which the citrate anticoagulation branch continuously outputs citric acid is greater than or equal to the maximum output time of the citrate anticoagulation branch, a fault prompt operation is issued.

[0078] It should be noted that the time for determining that the citrate anticoagulation branch continuously outputs citrate does not include the cumulative time for the citrate anticoagulation branch to output citrate. For example, when the citrate output of the citrate anticoagulation branch is interrupted, it is necessary to recalculate the time for the citrate anticoagulation branch to continuously output citrate.

[0079] The human body has a maximum safe value for the total amount of citrate. Once the total amount of citrate flowing into the human body is greater than or equal to the maximum safe value, it will affect the patient's physiological safety, for example, there is a risk of massive bleeding. During the citrate anticoagulation control process, it is necessary to calculate the time that the citrate anticoagulation branch continuously outputs citrate. The time that the citrate anticoagulation branch outputs citrate can be used to evaluate whether the total amount of citrate exceeds the maximum safe value. The fault prompt operation can prompt the user whether the total amount of citrate flowing into the human body is abnormal. Therefore, this embodiment can determine whether the total amount of citrate continuously output by the citrate anticoagulation branch exceeds the maximum safe value, so as to ensure the safety of the patient's citrate anticoagulation control process.

[0080] It should be noted that the maximum safe value of the total amount of citric acid is a universal value known in advance by those skilled in the art.

[0081] After the output flow of citric acid is obtained, the maximum output time of the citric acid anticoagulation branch can be set according to the output flow of citric acid. Generally speaking, the greater the output flow of citric acid, the smaller the maximum output time of the citric acid anticoagulation branch. For example, the maximum safety value of the total amount of citric acid connected to the human body is 0.3L. If the calculated output flow of citric acid is: 30ml / h, the maximum output time is: maximum safety value / citric acid output flow = (300 / 30)h = 10h; if the time detection module detects that the time for the citric acid anticoagulation branch to continuously output citric acid is greater than or equal to 10h, a fault prompt operation is issued. Therefore, this embodiment can prevent the total amount of citric acid connected to the human body from being too large according to the time for the citric acid anticoagulation branch to continuously output citric acid.

[0082] It should be noted that the fault prompt operation in this embodiment is an audio-visual signal. If the judgment module determines that the time for which the citrate anticoagulation branch continuously outputs citrate is greater than or equal to the maximum output time of the citrate anticoagulation branch, a sound prompt operation may be issued, or a text prompt operation may be displayed on the display screen to achieve the effect of a fault alarm.

[0083] Specifically, as another optional implementation, the citric acid adjustment mode of the blood purification device is set to a speed mode, and the judgment module is also used to judge whether the citric acid flow rate is within a first preset safety range, and judge whether the calcium solution flow rate is within a second preset safety range;

[0084] In the speed mode, the citric acid flow rate of the citric acid anticoagulation branch and the calcium solution flow rate of the calcium solution anticoagulation branch are determined according to the rate setting instruction output by the user; the judgment module judges whether the citric acid flow rate is within the first preset safety range, and judges whether the calcium solution flow rate is within the second preset safety range;

[0085] If the judgment module determines that the citric acid flow rate is within the first preset safety range and the calcium solution flow rate is within the second preset safety range, the citric acid branch control module controls the citric acid anticoagulation branch to output citric acid to the arterial line according to the citric acid flow rate; the calcium solution branch control module controls the calcium solution anticoagulation branch to output calcium solution to the venous line according to the calcium solution flow rate.

[0086] In speed mode, after determining the citric acid flow rate of the citrate anticoagulation branch and the calcium solution flow rate of the calcium solution anticoagulation branch according to the rate setting instruction output by the user, in order to ensure the safety of the blood purification process, it is also necessary to verify whether the citric acid flow rate and the calcium solution flow rate are both within a safe range, wherein the first preset safety range represents the safety range of the citric acid flow rate, and the second preset safety range represents the safety range of the calcium solution flow rate. The first preset safety range and the second preset safety range are generally applicable to all patients. Only when the citric acid flow rate is within the first preset safety range and the calcium solution flow rate is within the second preset safety range, can the patient's citrate anticoagulation process remain in a safe state. If the citric acid flow rate is not within the first preset safety range and / or the calcium solution flow rate is not within the second preset safety range, it is necessary to reset the citric acid flow rate of the citrate anticoagulation branch and the calcium solution flow rate of the calcium solution anticoagulation branch in speed mode. It should be noted that technicians in this field can determine the first preset safety range and the second preset safety range based on clinical experience. For example, the first preset safety range is 10ml / h to 50ml / h, and the second preset safety range is 5ml / h to 45ml / h.

[0087] Based on the above embodiment, as an optional implementation, the blood purification device further includes a first detection module, and the first detection module is used to detect the blood flow of the arterial line;

[0088] Determining a first ratio between the citric acid flow rate and the blood flow rate according to the detection value of the first detection module;

[0089] Determining a second ratio between the calcium solution flow rate and the citric acid flow rate according to the calcium solution flow rate and the citric acid flow rate;

[0090] The judging module is further used to judge whether the first ratio is within a first safety range, and to judge whether the second ratio is within a second safety range;

[0091] If the judgment module determines that the first ratio is within the first safety range and the second ratio is within the second safety range, the citric acid branch control module controls the citric acid anticoagulation branch to output citric acid to the arterial line according to the citric acid flow rate; the calcium liquid branch control module controls the calcium liquid anticoagulation branch to output calcium liquid to the venous line according to the calcium liquid flow rate;

[0092] If the judgment module judges that the first ratio is not within the first safety range and / or the second ratio is not within the second safety range, a fault prompt operation is issued.

[0093] Specifically, in speed mode, after the user directly sets the citric acid flow and the calcium solution flow, it is also necessary to judge whether the citric acid flow and the blood flow are matched according to the first ratio, and whether the calcium solution flow and the citric acid flow are matched according to the second ratio. Only when the first ratio is in the first safety range and the second ratio is in the second safety range, the blood flow, the citric acid flow and the calcium solution flow can maintain a matching relationship. Citric acid plays an anticoagulant role in blood pressure, and the citric acid flow and the calcium solution flow are balanced to prevent patients from having hypercalcemia or hypocalcemia during the citric acid anticoagulation process, thereby ensuring the safety of citric acid anticoagulation control during blood pressure purification treatment. In this embodiment, the first ratio between the citric acid flow and the blood flow, and the second ratio between the calcium solution flow and the citric acid flow are verified to be in a safe range, which ensures the safety of the citric acid anticoagulation control process of the blood purification device in speed mode.

[0094] It should be noted that those skilled in the art can pre-set the first safety range and the second safety range based on clinical experience, for example, the first safety range is 0.01 to 0.25, and the second safety range is 0.25 to 0.33.

[0095] It should be noted that the fault prompt operation in this embodiment is an audio-visual signal. If the judgment module determines that the first ratio is not within the first safety range and / or the second ratio is not within the second safety range, a sound prompt operation can be issued, or a text prompt operation can be displayed on the display screen to achieve the effect of a fault alarm.

[0096] Since the blood purification equipment can realize multiple blood purification treatment modes, in order to better match different blood purification treatment modes, in the speed mode, before the first detection module detects the blood flow in the arterial line, the first safety range of the blood purification equipment can be set according to different blood purification treatment modes, so that the first safety range can be set more accurately, thereby ensuring the safety of the citrate anticoagulation control process in the speed mode.

[0097] The first safety range of the blood pressure purification device can be preset according to the pipeline characteristics of the blood purification treatment mode, specifically:

[0098] In the first type, that is, the blood purification device does not have a waste liquid branch and a plasma branch, then in this mode, the first safety range is 0.01 to 0.1;

[0099] In the second type, that is, there is a waste liquid branch or a plasma branch in the blood purification device, then in this mode, the first safety range is 0.1 to 0.2;

[0100] In the third type, that is, the blood purification equipment has a waste liquid branch and a plasma branch, then in this mode, the first safety range is 0.2 to 0.25.

[0101] The most appropriate first safety range is selected according to each blood pressure purification treatment mode to accurately determine whether the citrate flow rate and the calcium solution flow rate are set appropriately, which is beneficial to ensure the safety of the citrate anticoagulation control process in the speed mode.

[0102] Combination Figure 1 As shown, the venous line 20 includes a first branch 21 and a second branch 22. The first branch 21 is located between the blood output end of the blood purifier 30 and the input end of the venous pot 50. The calcium liquid anticoagulation branch 70 is connected to the input end of the venous pot 50. The second branch 22 is connected to the outlet end of the venous pot 50. The venous pot 50 utilizes the principle of atmospheric pressure balance to buffer the blood flow rate and remove blood bubbles.

[0103] Based on the above embodiment, as an optional implementation, the blood purification device further includes a third detection module, a fourth detection module and a fifth detection module, wherein: the third detection module is used to detect the liquid flow of the first branch to obtain a first detection flow;

[0104] The fourth detection module is used to detect the liquid flow of the calcium solution anticoagulation branch to obtain a second detection flow;

[0105] The fifth detection module is used to detect the liquid flow rate of the second branch to obtain a third detection flow rate;

[0106] The judgment module is also used to judge whether the first detection flow rate, the second detection flow rate and the third detection flow rate meet a preset condition, and the preset condition is: |first detection flow rate+second detection flow rate-third detection flow rate|≤preset flow rate error;

[0107] If the judgment module judges that the first detection flow rate, the second detection flow rate and the third detection flow rate meet the preset conditions, the intravenous bottle is in a safe liquid flow state;

[0108] If the judgment module determines that the first detection flow rate, the second detection flow rate and the third detection flow rate do not meet the preset conditions, the intravenous kettle is in a faulty liquid flow state.

[0109] Specifically, the first branch outputs the purified blood to the venous pot, the calcium liquid anticoagulation branch outputs the calcium liquid to the venous pot, and the second branch outputs the blood in the venous pot to the human body's veins; when the liquid level of the venous pot is maintained at a normal level, the total liquid flow rate flowing into the venous pot (that is, the sum of the first detection flow rate and the second detection flow rate) and the total liquid flow rate flowing out of the venous pot (that is, the third detection flow rate) should be approximately equal, that is, the first preset condition is met, then it is judged that the venous pot is in a safe flow state, and the liquid level in the venous pot is in a stable state; when the total liquid flow rate flowing into the venous pot and the total liquid flow rate flowing out of the venous pot are very different and the first preset condition is not met, then it is judged that the venous pot is in a faulty liquid flow state, and the liquid level of the venous pot suddenly rises or suddenly drops, which may be due to leakage in the venous pot or blockage in the venous pot, causing the venous pot to be in a faulty liquid flow state.

[0110] This embodiment can accurately determine whether the intravenous kettle is in a safe liquid flow state based on the liquid flow of the first branch, the liquid flow of the calcium liquid anticoagulation branch, and the liquid flow of the second branch, thereby further ensuring the safety of the patient's blood purification treatment.

[0111] It should be noted that technicians in this field can set the range of preset flow error according to actual conditions (including factors such as the length of the first branch, the length of the second branch, and the capacity of the intravenous pot), for example, the range of preset flow error is 0.3ml / min to 1.0ml / min.

[0112] Based on the above embodiment, as an optional implementation, the fifth detection module in the blood purification device can also be used to detect the calcium ion concentration of the blood in the second branch;

[0113] The judgment module is also used to judge whether the calcium ion concentration of the blood in the second branch is within the preset safety concentration range. If the calcium ion concentration of the blood in the second branch is within the preset safety concentration range, the blood purification equipment operates normally. If the calcium ion concentration of the blood in the second branch is not within the preset safety concentration range, a fault prompt operation is issued.

[0114] Specifically, combined Figure 1As shown, after the calcium solution and the purified blood are mixed in the venous pot 50, the venous pot 23 outputs the blood to the second branch 22. The blood in the second branch 22 represents the blood that is returned to the patient's body. According to the calcium ion concentration of the blood in the second branch 22, it can be judged whether the purified blood has hypercalcemia or hypocalcemia. Among them, the preset safety concentration range represents the standard calcium ion concentration range in human blood. The preset safety concentration range belongs to common sense data in the prior art and can be obtained by consulting relevant books. This embodiment does not make further limitations on this. For example, the preset safety concentration range is: 1.0-1.3mmol / L. If the calcium ion concentration of the blood in the second branch is detected to be 0.6mmol / L, it means that the blood in the second branch has hypocalcemia, and the calcium solution output by the calcium solution anticoagulation branch is too little; if the calcium ion concentration of the blood in the second branch is detected to be: 1.6mmol / L, it means that the blood in the second branch has hypercalcemia, and the calcium solution output by the calcium solution anticoagulation branch is too high. This embodiment can prompt the user through the fault prompt operation: the calcium ion concentration of the blood in the second branch is in a fault state, and the user can promptly feedback and adjust the citrate anticoagulation control process to ensure that the calcium ion concentration of the blood in the second branch is within a preset safe concentration range.

[0115] It should be noted that the fault prompt operation in this embodiment is an audio-visual signal. If the judgment module determines that the calcium ion concentration of the blood in the second branch is not within the preset safe concentration range, a sound prompt operation can be issued, or a text prompt operation can be displayed on the display screen to achieve the effect of a fault alarm.

[0116] Combination Figure 1 As shown, the arterial line 10 includes a third branch 11 and a fourth branch 12. One end of the third branch 11 is connected to the blood input end of the blood purifier 30, one end of the fourth branch 12 is connected to the human artery, and the other end of the third branch 11 and the other end of the fourth branch 12 are connected to the citrate anticoagulation branch 60.

[0117] Based on the above embodiment, as an optional implementation, the blood purification device further includes a sixth detection module, which is used to detect the calcium ion concentration in the fourth branch;

[0118] The judgment module is also used to judge the magnitude of the absolute value of the difference between the calcium ion concentration of the blood in the second branch and the calcium ion concentration of the blood in the fourth branch and a preset value;

[0119] If the absolute value of the difference between the calcium ion concentration of the blood in the second branch and the calcium ion concentration of the blood in the fourth branch is greater than a preset value, a fault prompt operation is performed.

[0120] Specifically, the calcium ion concentration of the blood in the fourth branch represents the calcium ion concentration of the blood in the patient's body, and the difference between the calcium ion concentration of the blood in the second branch and the calcium ion concentration of the blood in the fourth branch represents: the calcium ion concentration fluctuation caused by the citrate anticoagulation control process; if the citrate anticoagulation control process is in a normal and safe state, the absolute value of the difference is less than or equal to the preset value; if the citrate anticoagulation control process is in an abnormal state (such as hypercalcemia, hypocalcemia), the absolute value of the difference is greater than the preset value. This embodiment uses a judgment module to judge the absolute value of the difference between the calcium ion concentration of the blood in the second branch and the calcium ion concentration of the blood in the fourth branch and the preset value, and can timely determine whether the citrate anticoagulation control process causes abnormal calcium ion concentration in the blood, and prompt the user through a fault prompt operation that the calcium ion concentration in the blood is abnormal, so that the user can adjust the citrate anticoagulation control process in time to ensure the safety of the patient's blood purification process.

[0121] There will be slight differences in the calcium ion concentration in the blood of each patient, but generally speaking, the preset value range is 0.1mmol / L to 0.3mmol / L.

[0122] It should be noted that the fault prompt operation in this embodiment is an audio-visual signal. If the judgment module determines that the absolute value of the difference between the calcium ion concentration of the blood in the second branch and the calcium ion concentration of the blood in the fourth branch is greater than a preset value, a sound prompt operation can be issued, or a text prompt operation can be displayed on the display screen to achieve the effect of a fault alarm.

[0123] In the above embodiment, the judgment module judges whether the calcium ion concentration of the blood in the second branch is within the preset safety concentration range, and can judge whether the purified blood meets the standard calcium ion concentration in human blood. The judgment module judges the absolute value of the difference between the calcium ion concentration of the blood in the second branch and the calcium ion concentration of the blood in the fourth branch and the preset value, and can judge whether the calcium ion concentration changes dramatically before and after blood purification.

[0124] Based on the above embodiment, as an optional implementation mode, the citrate adjustment mode of the blood purification device is set to speed mode. After the citrate flow rate of the citrate anticoagulation branch is determined according to the rate setting instruction output by the user, the maximum delivery time of the citrate anticoagulation branch can be set according to the citrate flow rate.

[0125] The blood purification device detects the time for which the citrate anticoagulation branch continuously outputs citrate through a time detection module;

[0126] The judgment module determines whether the time for which the citrate anticoagulation branch continuously outputs citric acid is greater than or equal to the maximum output time of the citrate anticoagulation branch. If the time for which the citrate anticoagulation branch continuously outputs citric acid is greater than or equal to the maximum output time of the citrate anticoagulation branch, a fault prompt operation is issued.

[0127] It should be noted that the principle of using the judgment module to determine whether the time for which the citrate anticoagulation branch continuously outputs citrate is greater than or equal to the maximum output time of the citrate anticoagulation branch in the speed mode is basically the same as the principle of using the judgment module to determine whether the time for which the citrate anticoagulation branch continuously outputs citrate is greater than or equal to the maximum output time of the citrate anticoagulation branch in the proportional mode, and will not be repeated here.

[0128] Based on the above embodiment, as an optional implementation, the blood purification device further includes: a first temperature detection module, the first temperature detection module is used to detect the temperature of citric acid in the citric acid anticoagulation branch;

[0129] The citric acid branch control module controls the citric acid anticoagulation branch to output citric acid to the arterial line according to the output flow rate of citric acid, and the first temperature detection module detects the temperature of citric acid in the citric acid anticoagulation branch to obtain the temperature of citric acid;

[0130] The judgment module is also used to judge whether the temperature of citric acid is greater than the preset indoor temperature. If the judgment module judges that the temperature of citric acid is greater than the preset indoor temperature, the citric acid branch control module controls the citric acid anticoagulation branch to output citric acid to the arterial line according to the output flow of citric acid.

[0131] Specifically, see Figure 1 , one end of the citric acid anticoagulation branch 60 is connected to a liquid storage bag, the liquid storage bag is used to pre-store citric acid, and the other end of the citric acid anticoagulation branch 60 is connected to the arterial line 10, and the citric acid is output to the arterial line 10 through the citric acid anticoagulation branch 60; wherein the citric acid in the liquid storage bag belongs to the external liquid, and the liquid storage bag is located in the external environment, which will cause the temperature of the citric acid in the liquid storage bag to drop. Therefore, in order to ensure the safety of citric acid anticoagulation, the temperature of the citric acid must be greater than the preset indoor temperature. Only when the temperature of the citric acid is greater than the preset indoor temperature, when the citric acid is output to the arterial line, will it not cause the temperature of the blood in the arterial line to drop suddenly and sharply, so that the temperature during the blood purification treatment process remains normal. When the temperature of the citric acid is less than or equal to the preset indoor temperature, in this case, the temperature of the citric acid is too low, which will cause the temperature of the blood in the arterial line to drop, and damage the safety of the patient's blood purification treatment. When the temperature of citric acid is less than or equal to the preset indoor temperature, the citric acid anticoagulation branch will not output citric acid to the arterial line, thereby ensuring the safety of citric acid anticoagulation control.

[0132] It should be noted that the preset indoor temperature represents the normal temperature of the external environment, and those skilled in the art can set it according to actual conditions, for example, the preset indoor temperature is 30°C.

[0133] Based on the above embodiment, as an optional implementation, the blood purification device further includes: a second temperature detection module, the second temperature detection module is used to detect the temperature of the calcium solution in the calcium solution anticoagulation branch;

[0134] Before the calcium liquid branch control module controls the calcium liquid anticoagulation branch to output the calcium liquid to the venous line according to the calcium liquid flow rate, the second temperature detection module detects the temperature of the calcium liquid in the calcium liquid anticoagulation branch to obtain the temperature of the calcium liquid;

[0135] The judgment module is also used to judge whether the temperature of the calcium solution is greater than the preset indoor temperature. If the judgment module judges that the temperature of the calcium solution is greater than the preset indoor temperature, the calcium solution branch control module controls the calcium solution anticoagulation branch to output the calcium solution to the venous pipeline according to the calcium solution flow rate.

[0136] Specifically, see Figure 1 , one end of the calcium liquid anticoagulation branch 70 is connected to a liquid storage bag, the liquid storage bag is used to store calcium liquid in advance, and the other end of the calcium liquid anticoagulation branch 70 is connected to the venous line, and the calcium liquid is output to the venous line through the calcium liquid anticoagulation branch 70; wherein the calcium liquid in the liquid storage bag belongs to an external liquid, and the liquid storage bag is located in the external environment, which will cause the temperature of the calcium liquid in the liquid storage bag to drop, so in order to ensure the safety of citric acid anticoagulation, the temperature of the calcium liquid must be greater than the preset indoor temperature, and only when the temperature of the calcium liquid is greater than the preset indoor temperature, when the calcium liquid is output to the venous line, will it not cause the temperature of the blood in the venous line to drop suddenly and substantially, so that the temperature in the blood purification treatment process remains normal. When the temperature of the calcium liquid is less than or equal to the preset indoor temperature, the temperature of the calcium liquid is too low in this case, which will cause the temperature of the blood in the venous line to drop, and damage the safety of the patient's blood purification treatment. When the temperature of the calcium liquid is less than or equal to the preset indoor temperature, the calcium liquid anticoagulation branch will not output the calcium liquid to the venous line, thereby ensuring the safety of citric acid anticoagulation control.

[0137] It should be noted that the preset indoor temperature represents the normal temperature of the external environment, and those skilled in the art can set it according to actual conditions, for example, the preset indoor temperature is 30°C.

[0138] In this embodiment, by detecting the temperature of citric acid in the citrate anticoagulation branch and the temperature of calcium solution in the calcium solution anticoagulation branch, it is possible to prevent the blood temperature from being too low during the citrate anticoagulation control process, thereby preventing the safety of the patient's blood purification treatment from being damaged.

[0139] On the basis of the above embodiment, as an optional implementation manner, before the citric acid branch control module controls the citric acid anticoagulation branch to output citric acid to the arterial line according to the output flow rate of citric acid, and the calcium liquid branch control module controls the calcium liquid anticoagulation branch to output calcium liquid to the venous line according to the calcium liquid flow rate, the blood purification device determines whether the temperature of citric acid in the citric acid anticoagulation branch and the temperature of calcium liquid in the calcium liquid anticoagulation branch meet the second preset condition through the judgment module, wherein the second preset condition is:

[0140] |The temperature of citric acid in the citric acid anticoagulation branch - the temperature of calcium solution in the calcium solution anticoagulation branch|≤ the preset temperature difference.

[0141] Specifically, in the citric acid anticoagulation control process, this embodiment controls the temperature of citric acid and the temperature of calcium solution to be similar (that is, to meet the second preset condition), which can help simplify the liquid temperature control steps in the blood purification treatment process, and citric acid and calcium solution will not cause drastic changes in blood temperature, ensuring that the temperature of the purified blood can be maintained at a safe temperature level; if the temperature of citric acid and the temperature of calcium solution do not meet the second preset condition, the addition of citric acid to the arterial line will cause blood temperature changes, and the addition of calcium solution to the arterial line will also cause blood temperature changes, and the degree of blood temperature changes caused by the two are inconsistent, which will increase the difficulty of detecting and controlling blood temperature during blood purification treatment.

[0142] If the temperature of citric acid in the citric acid anticoagulation branch and the temperature of calcium liquid in the calcium liquid anticoagulation branch do not meet the second preset condition, the temperature of citric acid in the citric acid anticoagulation branch and the temperature of calcium liquid in the calcium liquid anticoagulation branch can be adjusted and controlled to meet the second preset condition.

[0143] The preset temperature difference refers to the allowable temperature error range, and those skilled in the art can set it according to actual conditions. For example, the preset temperature difference is 2°C.

[0144] The blood purification device provided in this embodiment is provided with a citric acid adjustment module. When adjusting the citric acid, the medical staff can select the proportional mode or the speed mode. In the proportional mode, the medical staff can conveniently select the citric acid flow of the citric acid anticoagulation branch and the calcium liquid flow of the calcium liquid anticoagulation branch in a ratio manner, so that the citric acid flow, the calcium liquid flow and the blood flow of the arterial line can be kept matched. The proportional mode is suitable for some medical staff who lack clinical technical experience; in the speed mode, the medical staff can set the citric acid flow and the calcium liquid flow at will, and the setting flexibility is high. The speed mode is suitable for some medical staff with rich clinical experience; in the blood purification device provided in this embodiment, the medical staff can select the proportional mode or the speed mode according to their own operating habits, which brings a better use experience to the medical staff, and the blood purification device provided in this embodiment improves the safety of blood purification treatment of the blood purifier during the citrate anticoagulation control process, and the blood purification device has a higher scope of application.

[0145] The blood purification device of the embodiment of the present invention further includes a memory and a processor, and the processor and the memory communicate with each other through a bus; the memory stores program instructions executable by the processor, and the processor calls the program instructions to execute the following method:

[0146] According to the selection instruction output by the user, the citric acid regulation mode of the blood purification device is determined, wherein the citric acid regulation mode includes a proportional mode and a speed mode. In the proportional mode, the ratio of the citric acid flow rate of the citric acid anticoagulation branch to the blood flow rate of the arterial line, and the ratio of the calcium liquid flow rate of the calcium liquid anticoagulation branch to the citric acid flow rate of the citric acid anticoagulation branch are both constant values; in the speed mode, the citric acid flow rate of the citric acid anticoagulation branch and the calcium liquid flow rate of the calcium liquid anticoagulation branch are both constant values;

[0147] According to the citrate regulation mode, the citrate anticoagulation branch is controlled to output citrate to the arterial line;

[0148] According to the citrate regulation method, the calcium solution anticoagulation branch is controlled to output calcium solution to the venous line.

[0149] Compared with the prior art, the electronic device is provided with a citric acid adjustment module. When adjusting the citric acid, the medical staff can select the proportional mode or the speed mode. In the proportional mode, the medical staff can conveniently select the citric acid flow of the citric acid anticoagulation branch and the calcium liquid flow of the calcium liquid anticoagulation branch in a ratio manner, so that the citric acid flow, the calcium liquid flow and the blood flow of the arterial line can be kept matched. The proportional mode is suitable for some medical staff who lack clinical technical experience; in the speed mode, the medical staff can set the citric acid flow and the calcium liquid flow at will, and the setting flexibility is high. The speed mode is suitable for some medical staff with rich clinical experience; in the blood purification equipment provided in this embodiment, the medical staff can select the proportional mode or the speed mode according to their own operating habits, which brings a better use experience to the medical staff, and the blood purification equipment provided in this embodiment improves the safety of the blood purification treatment of the blood purifier during the citrate anticoagulation control process, and the blood purification equipment has a higher scope of application.

[0150] It should be noted that the first to sixth detection modules in this embodiment can use flow meters or flow sensors, the time detection module can use a clock, etc., and the first temperature detection module and the second temperature detection module can use a thermometer or temperature sensor. Technicians in this field can make a choice based on actual conditions, and this embodiment does not make further limitations on this.

[0151] In an optional embodiment, a blood purification device is provided, such as Figure 4 As shown, Figure 4 The electronic device 400 shown includes: a processor 401 and a memory 403. The processor 401 and the memory 403 are connected, such as through a bus 402. Optionally, the electronic device 400 may also include a transceiver 404. It should be noted that in actual applications, the transceiver 404 is not limited to one, and the structure of the electronic device 400 does not constitute a limitation on the embodiments of the present application.

[0152] Processor 401 may be a CPU (Central Processing Unit), a general purpose processor, a DSP (Digital Signal Processor), an ASIC (Application Specific Integrated Circuit), an FPGA (Field Programmable Gate Array) or other programmable logic devices, transistor logic devices, hardware components or any combination thereof. It may implement or execute various exemplary logic blocks, modules and circuits described in conjunction with the disclosure of this application. Processor 401 may also be a combination that implements computing functions, such as a combination of one or more microprocessors, a combination of a DSP and a microprocessor, etc.

[0153] The bus 402 may include a path to transmit information between the above components. The bus 402 may be a PCI (Peripheral Component Interconnect) bus or an EISA (Extended Industry Standard Architecture) bus. The bus 402 may be divided into an address bus, a data bus, a control bus, etc. For ease of representation, Figure 4 Only one thick line is used in the diagram, but this does not mean that there is only one bus or only one type of bus.

[0154] The memory 403 can be a ROM (Read Only Memory) or other types of static storage devices that can store static information and instructions, a RAM (Random Access Memory) or other types of dynamic storage devices that can store information and instructions, or an EEPROM (Electrically Erasable Programmable Read Only Memory), a CD-ROM (Compact Disc Read Only Memory) or other optical disk storage, optical disk storage (including compressed optical disk, laser disk, optical disk, digital versatile disk, Blu-ray disk, etc.), a magnetic disk storage medium or other magnetic storage device, or any other medium that can be used to carry or store the desired program code in the form of instructions or data structures and can be accessed by a computer, but is not limited to these.

[0155] The memory 403 is used to store the application code for executing the solution of the present application, and the execution is controlled by the processor 401. The processor 401 is used to execute the application code stored in the memory 403 to implement the contents shown in the above method embodiment.

[0156] A third aspect of an embodiment of the present invention provides a computer-readable storage medium, on which a computer program is stored, and when the computer program is executed by a processor, the following method is implemented:

[0157] According to the selection instruction output by the user, the citric acid regulation mode of the blood purification device is determined, wherein the citric acid regulation mode includes a proportional mode and a speed mode. In the proportional mode, the ratio of the citric acid flow rate of the citric acid anticoagulation branch to the blood flow rate of the arterial line, and the ratio of the calcium liquid flow rate of the calcium liquid anticoagulation branch to the citric acid flow rate of the citric acid anticoagulation branch are both constant values; in the speed mode, the citric acid flow rate of the citric acid anticoagulation branch and the calcium liquid flow rate of the calcium liquid anticoagulation branch are both constant values;

[0158] According to the citrate regulation mode, the citrate anticoagulation branch is controlled to output citrate to the arterial line;

[0159] According to the citrate regulation method, the calcium solution anticoagulation branch is controlled to output calcium solution to the venous line.

[0160] Compared with the prior art, the computer-readable storage medium is provided with a citric acid adjustment module. When adjusting the citric acid, the medical staff can select the proportional mode or the speed mode. In the proportional mode, the medical staff can conveniently select the citric acid flow of the citric acid anticoagulation branch and the calcium liquid flow of the calcium liquid anticoagulation branch in a ratio manner, so that the citric acid flow, the calcium liquid flow and the blood flow of the arterial line can be preserved and matched. The proportional mode is suitable for some medical staff who lack clinical technical experience; in the speed mode, the medical staff can set the citric acid flow and the calcium liquid flow at will, and the setting flexibility is high. The speed mode is suitable for some medical staff with rich clinical experience; in the blood purification equipment provided in this embodiment, the medical staff can select the proportional mode or the speed mode according to their own operating habits, which brings a better use experience to the medical staff, and the blood purification equipment provided in this embodiment improves the safety of blood purification treatment of the blood purifier during the citrate anticoagulation control process, and the blood purification equipment has a higher scope of application.

[0161] It should be understood that, although the steps in the flowchart of the accompanying drawings are displayed in sequence as indicated by the arrows, these steps are not necessarily executed in sequence in the order indicated by the arrows. Unless otherwise specified herein, there is no strict order restriction on the execution of these steps, and they can be executed in other orders. Moreover, at least a part of the steps in the flowchart of the accompanying drawings may include multiple sub-steps or multiple stages, and these sub-steps or stages are not necessarily executed at the same time, but can be executed at different times, and their execution order is not necessarily sequential, but can be executed in turn or alternately with other steps or at least a part of the sub-steps or stages of other steps.

[0162] Although the disclosure is disclosed as above, the protection scope of the disclosure is not limited thereto. Those skilled in the art may make various changes and modifications without departing from the spirit and scope of the disclosure, and these changes and modifications will fall within the protection scope of the present invention.

Claims

1. A blood purification device, characterized in that: The device comprises a blood purifier, an arterial line, a venous line, a citrate anticoagulation branch and a calcium liquid anticoagulation branch, wherein the arterial line is connected to the blood input end of the blood purifier, the venous line is connected to the blood output end of the blood purifier, the citrate anticoagulation branch is connected to the arterial line, the calcium liquid anticoagulation branch is connected to the venous line, and further comprises: The citric acid regulating module determines the citric acid regulating mode of the blood purification device according to the selection instruction output by the user, wherein the citric acid regulating mode includes a proportional mode and a speed mode. In the proportional mode, the ratio of the citric acid flow rate of the citric acid anticoagulation branch to the blood flow rate of the arterial line, and the ratio of the calcium liquid flow rate of the calcium liquid anticoagulation branch to the citric acid flow rate of the citric acid anticoagulation branch are both constant values; in the speed mode, the citric acid flow rate of the citric acid anticoagulation branch and the calcium liquid flow rate of the calcium liquid anticoagulation branch are both constant values; A citric acid branch control module, used for controlling the citric acid anticoagulation branch to output the citric acid to the arterial line according to the citric acid regulation mode; The calcium solution branch control module is used to control the calcium solution anticoagulation branch to output the calcium solution to the venous line according to the citric acid regulation method.

2. The blood purification device according to claim 1, characterized in that: It also includes a first detection module, which is used to detect the blood flow of the arterial line; If the citric acid regulation mode of the blood purification device is set to a proportional mode, the blood flow of the arterial line is determined according to the detection value of the first detection module; the first flow ratio is determined according to the first proportional instruction output by the user; the output flow of the citric acid is determined according to the blood flow of the arterial line and the first flow ratio; the citric acid branch control module controls the citric acid anticoagulation branch to output the citric acid to the arterial line according to the output flow of the citric acid; wherein the first flow ratio is the ratio between the citric acid flow of the citric acid anticoagulation branch and the blood flow of the arterial line; According to the second proportional instruction output by the user, a second flow ratio is determined; according to the output flow of the citric acid and the second flow ratio, the calcium liquid flow is determined; the calcium liquid branch control module controls the calcium liquid anticoagulation branch to output the calcium liquid to the venous line according to the calcium liquid flow; wherein the second flow ratio is the ratio between the calcium liquid flow of the calcium liquid anticoagulation branch and the citric acid flow of the citric acid anticoagulation branch.

3. The blood purification device according to claim 1, characterized in that: It also includes a judgment module, which is used to judge whether the citric acid flow rate is within a first preset safety range, and whether the calcium solution flow rate is within a second preset safety range; If the citric acid regulation mode of the blood purification device is set to the speed mode, the citric acid flow rate of the citric acid anticoagulation branch and the calcium solution flow rate of the calcium solution anticoagulation branch are determined according to the rate setting instruction output by the user; The judging module judges whether the citric acid flow rate is within a first preset safety range, and judges whether the calcium solution flow rate is within a second preset safety range; If the judgment module determines that the citric acid flow rate is within the first preset safety range and the calcium solution flow rate is within the second preset safety range, the citric acid branch control module controls the citric acid anticoagulation branch to output the citric acid to the arterial line according to the citric acid flow rate; the calcium solution branch control module controls the calcium solution anticoagulation branch to output the calcium solution to the venous line according to the calcium solution flow rate.

4. The blood purification device according to claim 3, characterized in that: It also includes a first detection module, which is used to detect the blood flow of the arterial line; Determining a first ratio between the citric acid flow rate and the blood flow rate according to the detection value of the first detection module; Determining a second ratio between the calcium solution flow rate and the citric acid flow rate according to the calcium solution flow rate and the citric acid flow rate; The judging module is further used to judge whether the first ratio is within a first safety range, and to judge whether the second ratio is within a second safety range; If the judgment module determines that the first ratio is within a first safety range and the second ratio is within a second safety range, the citric acid branch control module controls the citric acid anticoagulation branch to output the citric acid to the arterial line according to the citric acid flow rate; the calcium liquid branch control module controls the calcium liquid anticoagulation branch to output the calcium liquid to the venous line according to the calcium liquid flow rate; If the judgment module determines that the first ratio is not within the first safety range and / or the second ratio is not within the second safety range, a fault prompt operation is issued.

5. The blood purification device according to claim 2, characterized in that: It also includes a display screen, through which a first flow ratio preset range and a second flow ratio preset range are displayed, the first flow ratio preset range is the ratio range between the citric acid flow of the citric acid anticoagulation branch and the blood flow of the arterial line, and the first flow ratio preset range is 0.01 to 0.25; the second flow ratio preset range is the ratio range between the calcium liquid flow of the calcium liquid anticoagulation branch and the citric acid flow of the citric acid anticoagulation branch; Determining the first flow ratio within a preset range of the first flow ratio according to a first ratio instruction output by a user; According to the second ratio instruction input by the user, the second flow ratio is determined within a preset range of the second flow ratio.

6. The blood purification device according to claim 5, characterized in that: It also includes a second detection module, which is used to detect whether the blood purification device has a waste liquid branch and / or a plasma branch during the blood purification process; If the second detection module detects that the waste liquid branch and the plasma branch do not exist in the blood purification device, the first flow ratio is preset in a range of 0.01 to 0.1; If the second detection module detects that the waste liquid branch or the plasma branch exists in the blood purification device, the first flow ratio is preset in a range of 0.1 to 0.2; If the second detection module detects that the waste liquid branch and the plasma branch exist in the blood purification device, the first flow ratio is preset in a range of 0.2 to 0.

25.

7. The blood purification device according to claim 3, characterized in that: The venous line includes a first branch, a second branch and a venous pot, the first branch is located between the blood output end of the blood purifier and the input end of the venous pot, the calcium liquid anticoagulation branch is connected to the input end of the venous pot, the second branch is connected to the outlet end of the venous pot, and the blood purification device also includes a third detection module, a fourth detection module and a fifth detection module: The third detection module is used to detect the liquid flow of the first branch to obtain a first detection flow; The fourth detection module is used to detect the liquid flow of the calcium solution anticoagulation branch to obtain a second detection flow; The fifth detection module is used to detect the liquid flow of the second branch to obtain a third detection flow; The judgment module is further used to judge whether the first detection flow rate, the second detection flow rate and the third detection flow rate meet a preset condition, wherein the preset condition is: |first detection flow rate+second detection flow rate-third detection flow rate|≤preset flow rate error; If the judgment module judges that the first detection flow rate, the second detection flow rate and the third detection flow rate meet the preset condition, the intravenous bottle is in a safe liquid flow state; If the judgment module determines that the first detection flow rate, the second detection flow rate and the third detection flow rate do not meet the preset condition, the intravenous kettle is in a faulty liquid flow state.

8. The blood purification device according to claim 7, characterized in that: The arterial pipeline includes a third branch and a fourth branch, one end of the third branch is connected to the blood input end of the blood purifier, one end of the fourth branch is connected to the human artery, the other end of the third branch and the other end of the fourth branch are connected to the citrate anticoagulation branch, and the blood purification device also includes a sixth detection module, which is used to detect the calcium ion concentration in the fourth branch; The fifth detection module is also used to detect the calcium ion concentration in the second branch; The judgment module is also used to judge the difference between the absolute value of the calcium ion concentration in the second branch and the calcium ion concentration in the fourth branch and a preset value; If the absolute value of the difference between the calcium ion concentration in the second branch and the calcium ion concentration in the fourth branch is greater than the preset value, a fault prompt operation is performed.

9. The blood purification device according to claim 1, characterized in that: The system also includes a memory and a processor, wherein the processor and the memory communicate with each other via a bus; the memory stores program instructions executable by the processor, and the processor calls the program instructions to execute the following method: According to the selection instruction output by the user, the citric acid regulation mode of the blood purification device is determined, wherein the citric acid regulation mode includes a proportional mode and a speed mode, in which in the proportional mode, the ratio of the citric acid flow rate of the citric acid anticoagulation branch to the blood flow rate of the arterial line, and the ratio of the calcium liquid flow rate of the calcium liquid anticoagulation branch to the citric acid flow rate of the citric acid anticoagulation branch are both constant values; in the speed mode, the citric acid flow rate of the citric acid anticoagulation branch and the calcium liquid flow rate of the calcium liquid anticoagulation branch are both constant values; According to the citrate regulation mode, the citrate anticoagulation branch is controlled to output the citrate to the arterial line, According to the citric acid regulation method, the calcium solution anticoagulation branch is controlled to output the calcium solution to the venous line.

10. A computer-readable storage medium having a computer program stored thereon, characterized in that: When the computer program is executed by a processor, the following method is implemented: According to the selection instruction output by the user, the citric acid regulation mode of the blood purification device is determined, wherein the citric acid regulation mode includes a proportional mode and a speed mode, in which in the proportional mode, the ratio of the citric acid flow rate of the citric acid anticoagulation branch to the blood flow rate of the arterial line, and the ratio of the calcium liquid flow rate of the calcium liquid anticoagulation branch to the citric acid flow rate of the citric acid anticoagulation branch are both constant values; in the speed mode, the citric acid flow rate of the citric acid anticoagulation branch and the calcium liquid flow rate of the calcium liquid anticoagulation branch are both constant values; According to the citrate regulation mode, controlling the citrate anticoagulation branch to output citrate to the arterial line; According to the citric acid regulation method, the calcium solution anticoagulation branch is controlled to output the calcium solution to the venous line.

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