A reusable fully implantable sensor and preparation method thereof

Abstract

The present application provides a reusable fully implantable sensor and a preparation method, which relates to the field of sensors. The conductive element of the reusable fully implantable sensor is used to electrically connect a detection circuit and a detection electrode. The conductive element includes a base fixed on a circuit board, an elastic key arranged in the base, and a conductive contact arranged on the elastic key. The conductive element structure is electrically connected to the circuit board, and the conductive contact can move up and down. When the conductive contact of the conductive element contacts the detection electrode, the detection circuit and the detection electrode can be electrically connected. The conductive element has a simple structure, and the electrical connection method can be repeatedly realized. The circuit board can be reused after being disassembled.

Description

Technical Field

[0001] The present application relates to the field of sensors, and in particular to a reusable fully implantable sensor and a preparation method thereof. Background Art

[0002] Currently, fully implantable sensors on the market usually require complex connectors to connect the detection circuit and the detection electrode. For example, in patent document CN110448308 A, the detection electrode needs to be inserted into the slot of the conductive connection component. However, this structure is only suitable for fully implantable sensors that are integrally formed. After the circuit board and the conductive connection component are disassembled, it is difficult to reset them so that the detection electrode is inserted into the slot of the conductive connection component, which is not convenient for the reuse of the fully implantable sensor. Summary of the invention

[0003] The purpose of the present application is to provide a reusable fully implantable sensor and a preparation method, aiming to solve the problems that the conductive connection components of the existing fully implantable sensors are complex in structure, difficult to reset after disassembly, and the fully implantable sensors cannot be reused.

[0004] To achieve the above objectives, the present application provides a reusable fully implantable sensor, comprising:

[0005] A housing, wherein a detection electrode is disposed on the housing, a circuit board is disposed inside the housing, and a detection circuit is integrated on the circuit board;

[0006] A conductive element, used to electrically connect the detection circuit and the detection electrode, the conductive element comprising:

[0007] A base, wherein the base is fixed on the circuit board;

[0008] An elastic key, wherein the elastic key is arranged in the base;

[0009] The conductive contact is arranged on the elastic key.

[0010] Preferably, the elastic key is a spring.

[0011] Preferably, the fully implantable sensor further comprises:

[0012] At least two conductive contacts are arranged on the housing, the number of the conductive contacts corresponds to the number of the conductive contacts, and the detection electrodes are independently covered on the at least two conductive contacts;

[0013] The conductive contact abuts against the conductive contact point to achieve electrical connection between the detection circuit and the detection electrode.

[0014] Preferably, the housing comprises a housing body and a housing cap, the circuit board is arranged in the housing body, and the fully implantable sensor further comprises:

[0015] A connecting piece connected to one end of the circuit board facing the shell cap, and an end of the connecting piece away from the circuit board is provided with an accommodating space;

[0016] A protrusion is provided on the side of the shell cap facing the circuit board, and the protrusion includes a connecting rod connected to the shell cap, and a protrusion connected to the end of the connecting rod. The protrusion can be placed in the accommodating space so that the protrusion can be flexibly matched with the accommodating space, and the shell cap can pull the circuit board along the length direction of the shell body.

[0017] Preferably, a snap-in is provided on one side of the accommodating space facing the shell cap, and the protrusion is placed in the accommodating space through the snap-in, and the width of the snap-in is smaller than the width of the protrusion, so that when the shell cap pulls the circuit board along the length direction of the shell body, the protrusion can be stuck at the snap-in and will not fall off.

[0018] Preferably, the connector is further provided with a placement opening, the placement opening is connected to the accommodating space, the bayonet is a U-shaped opening opened on the end face of the connector, the placement opening is merged with the U-shaped opening, and the width of the placement opening is greater than the width of the bayonet, so that the protrusion can be freely taken and placed through the placement opening.

[0019] The present application also provides a method for preparing a reusable fully implantable sensor, comprising:

[0020] Preparing detection electrodes: arranging at least two conductive contacts on the housing, and arranging detection electrodes on the at least two conductive contacts respectively;

[0021] Prepare the conductive element: fix at least two conductive contacts on the circuit board integrated with the detection circuit, the number of the conductive contacts being the same as the number of the conductive contact points;

[0022] Assembling: inserting the circuit board provided with the conductive element into the housing so that the conductive contacts abut against the conductive contacts one by one, thereby realizing electrical connection between the detection circuit and the detection electrode;

[0023] seal.

[0024] Preferably, the step of respectively providing detection electrodes on the at least two conductive contacts comprises:

[0025] Preparing a conductive coating on the housing, wherein the conductive coating covers the at least two conductive contacts;

[0026] Cutting the conductive coating into at least two separate parts, so that each part of the conductive coating covers one of the conductive contacts;

[0027] providing an electrode layer on any portion of the conductive coating layer as a counter electrode;

[0028] An enzyme layer is disposed on at least a portion of the conductive coating outside the counter electrode as a working electrode.

[0029] Preferably, fixing at least two conductive contacts on a circuit board integrated with a detection circuit comprises:

[0030] At least two bases are fixed on the circuit board, elastic keys are arranged in the bases, and conductive contacts are arranged on the elastic keys.

[0031] Preferably, the housing comprises a housing body and a housing cap, and before inserting the circuit board provided with the conductive element into the housing, the housing further comprises:

[0032] Prepare a connector: the connector is used to connect with one end of the circuit board facing the shell cap, and an end of the connector away from the circuit board is provided with an accommodation space;

[0033] Prepare a shell cap: a protrusion is provided on one side of the shell cap facing the circuit board, the protrusion includes a connecting rod connected to the shell cap, and a convex block connected to the end of the connecting rod, the convex block can be placed in the accommodating space so that the protrusion and the accommodating space can be flexibly matched, and the shell cap can pull the circuit board along the length direction of the shell;

[0034] The circuit board, the connector and the shell cap are assembled and connected and then inserted into the shell body.

[0035] Compared with the prior art, the beneficial effects of this application include:

[0036] The conductive element of the reusable fully implantable sensor provided by the present application is used to electrically connect the detection circuit and the detection electrode. The conductive element includes a base fixed on the circuit board, an elastic key arranged in the base, and a conductive contact arranged on the elastic key. The conductive element structure is electrically connected to the circuit board, and the conductive contact can move up and down. When the conductive contact of the conductive element contacts the detection electrode, the detection circuit and the detection electrode can be electrically connected. The conductive element has a simple structure and the electrical connection method can be repeatedly realized. The conductive element is applied to the fully implantable sensor, and a conductive contact is arranged in the sensor housing. When the conductive element and the circuit board are inserted into the housing, the conductive contact is abutted against the conductive contact to realize electrical connection. The structure facilitates the removal of the circuit board. When the circuit board is replaced, it will not cause damage to the circuit board. The circuit board can be repeatedly inserted into the housing to meet the needs of different multi-index detection and save production resources.

[0037] The fully implantable sensor may further include a connector, which connects the circuit board and the shell cap. The protrusion of the shell cap flexibly cooperates with the accommodating space of the connector, and the protrusion can rotate within the accommodating space, so that the shell cap will not cause displacement of the circuit board during the process of tightening the sealing shell body, and will not cause damage to the circuit board, thereby improving product reliability and sealing. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present application and therefore should not be regarded as limiting the scope of the present application.

[0039] Figure 1 This is a schematic diagram of the overall structure of the fully implantable sensor of the present application;

[0040] Figure 2 is a cross-sectional view of a fully implantable sensor according to an embodiment of the present application;

[0041] Figure 3 A quarter cross-sectional view of a fully implantable sensor according to another embodiment of the present application;

[0042] Figure 4 This is a schematic diagram of the structure of the conductive element of the fully implantable sensor of the present application;

[0043] Figure 5 An exploded view of a fully implantable sensor according to another embodiment of the present application;

[0044] Figure 6 An exploded view of a circuit board, a connector, and a shell cap of a fully implantable sensor according to another embodiment of the present application;

[0045] Figure 7 A cross-sectional view of a fully implanted sensor in a pulled-apart state according to another embodiment of the present application;

[0046] Figure 8 A cross-sectional view of an assembled state of a fully implantable sensor according to another embodiment of the present application;

[0047] Fig. 9 It is a schematic diagram after the conductive contacts are arranged on the housing;

[0048] Fig.10 is a schematic diagram after preparing a conductive coating on a conductive contact;

[0049] Fig.11 This is a schematic diagram after cutting the conductive coating;

[0050] Fig.12 A schematic diagram showing the preparation of an electrode layer on one of the conductive layers;

[0051] Fig.13 is a schematic diagram after preparing an enzyme layer on another conductive layer;

[0052] Fig.14 Schematic diagram after enzyme cross-linking;

[0053] Fig.15 This is a schematic diagram of the preparation process of the fully implantable sensor of the present application.

[0054] Reference numerals:

[0055] 100-fully implantable sensor; 10-shell; 101-shell body; 102-shell cap; 12-conductive contact; 20-detection electrode; 22-counter electrode; 221-electrode layer; 24-working electrode; 241-enzyme layer; 26-reference electrode; 30-conductive coating; 32-conductive layer; 40-connector; 42-accommodating space; 43-bayonet; 44-placement port; 45-slot; 46-first bayonet port; 48-bayonet; 50-circuit board; 52-second bayonet port; 60-conductive element; 62-base; 64-elastic key; 66-conductive contact; 70-protrusion; 71-connecting rod; 72-bump. DETAILED DESCRIPTION

[0056] Embodiments of the present invention are described in detail below, examples of which are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as limiting the invention.

[0057] It should be noted that when an element is referred to as being "fixed to" another element, it may be directly on the other element or there may be a central element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. In contrast, when an element is referred to as being "directly on" another element, there is no intermediate element. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are for illustrative purposes only.

[0058] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0059] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0060] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which this application belongs. The terms used herein in the specification of the template are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more of the related listed items.

[0061] The present application provides a reusable fully implantable sensor, which includes a shell, a detection circuit and a detection electrode. The fully implantable sensor can be used to measure any one of blood sugar, uric acid, lactic acid, blood ketones or creatinine, or a combination of any multiple of these indicators.

[0062] See also Figures 1 to 4 The fully implantable sensor 100 includes: a shell 10, on which a detection electrode 20 is arranged, a circuit board 50 is arranged inside the shell 10, and the circuit board 50 is integrated with a detection circuit; and a conductive element 60 for electrically connecting the detection circuit and the detection electrode 20.

[0063] Among them, the detection circuit includes a micro battery, a wireless transmitter and an IC chip, and the IC chip integrates the functions of an analog signal processing module, a power management module, a blood sugar test module (or other detection indicators) and a communication module. The detection circuit is electrically connected to the detection electrode. The wireless transmitter of the detection circuit is connected to a receiver outside the body for communication. The detection circuit transmits the electrical signal or detection data to the receiver outside the body through the wireless transmitter, thereby realizing real-time detection of the data in the body. The wireless transmitter can be an antenna. The detection circuit enables the fully implantable sensor to independently complete the detection without connecting to an external device, and the detection circuit is connected to the external receiver for communication through the wireless transmitter. Therefore, the fully implantable sensor can be completely embedded in the tissue without reserving an opening on the tissue surface, further reducing the risk of wound infection.

[0064] See also Figure 4 The conductive element 60 includes: a base 62 , which is fixed on the circuit board 50 ; an elastic key 64 , which is arranged in the base 62 ; and a conductive contact 66 , which is arranged on the elastic key 64 .

[0065] The base 62, the elastic key 64 and the conductive contact 66 all have conductive properties, and the elastic key 64 can be a spring. Figure 3 When the conductive element 60 is not squeezed, its height will exceed the housing 10. After the conductive element 60 is installed into the housing 10 along with the circuit board 50, the conductive element 60 is squeezed by the housing 10 and contacts the detection electrode 20, thereby achieving electrical conduction between the circuit board 50 and the detection electrode 20.

[0066] The structure of the conductive element 60 can ensure that when the circuit board 50 is replaced, the circuit board 50 and the conductive element 60 will not be damaged. The circuit board 50 and the conductive element 60 can be repeatedly inserted into the housing 10 to meet the needs of different multi-index detection and save production resources. The fully implantable sensor 100 can also meet various customization needs and is more convenient to adjust. For example, the shell structure is consistent. When different detection indicators are required, only a different circuit board 50 needs to be installed or replaced with a different circuit board 50 without re-opening the mold.

[0067] In a preferred embodiment, see Figure 1 and Figure 5 The fully implantable sensor 100 further includes: at least two conductive contacts 12, which are arranged on the shell 10, the number of the conductive contacts 12 corresponds to the number of the conductive contacts 66, and the detection electrodes 20 are independently covered on the at least two conductive contacts 12; the conductive contacts 66 are in contact with the conductive contacts 12 to realize the electrical connection between the detection circuit and the detection electrode 20.

[0068] Among them, the conductive contact 12 is embedded in the shell 10. The conductive contact 12 can penetrate the inner and outer surfaces of the shell 10, or only penetrate the outer surface (applicable to the case where a space is formed between the inner and outer surfaces of the shell 10, and the circuit board 50 is arranged in the space) to achieve the connection between the circuit board 50 and the detection electrode 20 inside and outside the shell 10. The material of the conductive contact 12 can be conductive plastic, conductive rubber, metal, graphite and other conductive materials; the number of the conductive contacts 12 can be two, three, four or more. For electrochemical detection, the detection electrode should have at least one counter electrode and a working electrode, thereby forming a conventional two-electrode system. The conductive contacts 12 can also be three, so that a three-electrode system can be formed, including a counter electrode, a working electrode and a reference electrode. Among them, the working electrode can be set to multiple, so that multiple indicators can be detected at the same time, so the number of conductive contacts 12 increases accordingly.

[0069] Among them, the detection electrode 20 includes at least a working electrode 24 and a counter electrode 22, and may also include a reference electrode 26. The preparation method of the detection electrode can be prepared by adopting a traditional MEMS (Micro-Electro-Mechanical System) process, or by adopting the preparation method provided in the present application.

[0070] Preferably, see Figure 5 and Figure 6 The shell 10 includes a shell body 101 and a shell cap 102, the circuit board 50 is arranged in the shell body 101, and the fully implantable sensor 100 also includes: a connecting member 40, which is connected to one end of the circuit board 50 facing the shell cap 102, and the end of the connecting member 40 away from the circuit board 50 is provided with an accommodating space 42; the shell cap 102 is provided with a protrusion 70 on the side facing the circuit board 50, and the protrusion 70 includes a connecting rod 71 connected to the shell cap 102, and a protrusion 72 connected to the end of the connecting rod 71, and the protrusion 72 can be placed in the accommodating space 42 so that the protrusion 70 and the accommodating space 42 can be flexibly matched, and the shell cap 102 can pull the circuit board 50 along the length direction of the shell body 101.

[0071] The circuit board 50 and the shell cap 102 are connected by setting a connecting piece 40, and the protrusion 70 of the shell cap 102 is movably matched with the accommodating space 42 of the connecting piece 40. The protrusion 70 can rotate in the accommodating space 42, and a sealing element is provided at the proximal end of the connecting rod 71 and in the shell cap 102. Preferably, the sealing element is a sealing ring made of rubber, silicone, fluororubber or other materials, so that the shell cap 102 will not cause displacement of the circuit board 50 during the tightening process of the sealing shell body 101, and will not cause damage to the circuit board 50, thereby improving product reliability and sealing.

[0072] The connector 40 and the circuit board 50 can be connected in an integral manner or in a detachable manner, preferably in a detachable manner. All parts of the fully implantable sensor 100 are detachable, so that the fully implantable sensor 100 is used to produce various multi-indicator or single-indicator fully implantable sensors. The parts involved can be combined with each other to reduce production costs. In this solution, the shell body 101, shell cap 102, connector 40, and circuit board 50 components can be produced separately. Only when the enzyme layer of the detection electrode is coated, a different production line is required. The production line is relatively simple and the production efficiency is high.

[0073] Preferably, see Figure 6 and Figure 7A bayonet 43 is provided on one side of the accommodating space 42 facing the shell cap 102, and the protrusion 72 is placed in the accommodating space 42 through the bayonet 43, and the width of the bayonet 43 is smaller than the width of the protrusion 72, so that when the shell cap 102 pulls the circuit board 50 along the length direction of the shell body 101, the protrusion 72 can be stuck at the bayonet 43 and will not fall off.

[0074] Preferably, see Figure 6 The connector 40 is also provided with a placement opening 44, which is communicated with the accommodating space 42. The bayonet 43 is a U-shaped opening provided on the end face of the connector 40. The placement opening 44 is integrated with the U-shaped opening, and the width of the placement opening 44 is greater than the width of the bayonet 43, so that the protrusion 72 can be freely taken in and out through the placement opening 44.

[0075] In a preferred embodiment, see Figures 6 to 8 A slot 45 is provided at one end of the connector 40 connected to the circuit board 50, and a first bayonet opening 46 is provided in a direction not parallel to the slot 45. The first bayonet opening 46 passes through the slot 45. A second bayonet opening 52 is provided at one end of the circuit board 50 connected to the connector 40. The circuit board 50 is inserted into the slot 45 and the first bayonet opening 46 and the second bayonet opening 22 are inserted through a bayonet 48 to realize a detachable connection between the circuit board 50 and the connector 40.

[0076] The second bayonet opening 52 may be a circular hole through which the bayonet 48 can pass, and the second bayonet opening 52 is arranged in the circuit board 50. In this case, the circuit board 50 needs to be inserted into the slot 45 first, and then the bayonet 48 is inserted into the first bayonet opening 46 and the second bayonet opening 22. When disassembling, the bayonet 48 also needs to be taken out first. The second bayonet opening 52 may also be a U-shaped hole. In this case, the bayonet 48 may be inserted into the first bayonet opening 46 first, or the bayonet 48 may be fixedly arranged in the first bayonet opening 46 and formed integrally with the connector 40, and then the circuit board 50 is inserted into the slot 45 through the second bayonet opening 22 horizontally, so that the U-shaped hole is inserted into the bayonet 48. When disassembling, it is only necessary to take out the circuit board horizontally.

[0077] The various parts of the structure of the above fully implantable sensor 100 are detachably connected, and the shell body 101, circuit board 50, shell cap 102 and connector 40 can be disassembled, so that the parts involved in the production of various multi-indicator or single-indicator fully implantable sensors of the fully implantable sensor 100 can be combined with each other to reduce production costs.

[0078] The present application also provides a method for preparing a reusable fully implantable sensor, see Fig.15 ,include:

[0079] S100: preparing detection electrodes: arranging at least two conductive contacts on the housing, and arranging detection electrodes on the at least two conductive contacts respectively.

[0080] For details, please refer to Fig. 9 , the conductive contacts 12 are embedded in the housing 10, and the number of the conductive contacts 12 is consistent with the number of the detection electrodes. The number of the conductive contacts 12 can be two, three, four or more. The detection electrodes can include a counter electrode and a working electrode, and can also include a reference electrode. Among them, the working electrode can be set to multiple, so that multiple indicators can be detected at the same time, and thus the number of the conductive contacts 12 increases accordingly.

[0081] In a preferred embodiment, see Figures 10 to 14 , the detecting electrodes 20 are respectively provided on the at least two conductive contacts 12, including:

[0082] A conductive coating 30 is prepared on the housing 10 , and the conductive coating 30 covers the at least two conductive contacts 12 .

[0083] For details, please refer to Fig.10 The conductive coating 30 can be made of any conductive material such as silver, platinum, gold, palladium and oxides thereof. The conductive coating 30 can be made, for example, by sputtering, evaporation, chemical vapor deposition, electroplating, dip coating, screen printing, spraying and other processes.

[0084] By preparing the conductive coating 30 to cover all the conductive contacts 12, the conductive layer only needs to be prepared once, which can simplify the preparation process.

[0085] The conductive coating 30 is cut into at least two independent parts, so that each part of the conductive coating 30 covers one conductive contact 12, see Fig.11 .

[0086] The conductive coating 30 may be cut by any of laser cutting, rolling cutting, and plasma etching. The conductive coating 30 is cut to separate it into independent parts in space. The cutting depth of the conductive coating 30 should ensure that there is no connection between the independent conductive coating 30 parts, thereby forming spatial isolation and insulation. By cutting, the conductive coating 30 only needs to be prepared once to obtain multiple conductive layers 32, thereby simplifying the preparation method.

[0087] An electrode layer 221 is provided on any portion of the conductive coating 30 as a counter electrode 22, see Fig.12 and Fig.14 .

[0088] The electrode layer 221 can be arranged on any conductive layer 32, and the electrode layer 221 can be an Ag / AgCl layer; the thickness of the Ag / AgCl layer is 1 to 1000 nm; the preparation method of the electrode layer 221 can be any one of dip coating, screen printing, sputtering, evaporation, chemical vapor deposition, electroplating, and spraying.

[0089] An enzyme layer 241 is provided on at least one portion of the conductive coating 30 outside the counter electrode 22 as a working electrode 24, see Fig.13 and Fig.14 .

[0090] The working electrode 24 does not overlap with the counter electrode 22, and one enzyme layer 241 corresponds to forming one working electrode 24. For example, if only one indicator needs to be detected, an enzyme layer 241 is set on one conductive layer 30 to obtain one working electrode 24. If two indicators need to be detected, an enzyme layer 241 is set on each of the two conductive layers 30 to obtain two working electrodes 24.

[0091] The preparation method of the enzyme layer 241 is selected from any one of screen printing, sputtering, evaporation, chemical vapor deposition, electroplating, dipping, and spraying; the enzyme layer 241 is selected from any one or more of glucose oxidase, urate oxidase, lactate dehydrogenase, glucose dehydrogenase, peroxidase, β-hydroxybutyrate dehydrogenase, and sarcosine oxidase.

[0092] See also Fig.14 The detection electrode 20 may further include a conductive layer 32 between the counter electrode 22 and the working electrode 24 as a reference electrode 26 .

[0093] S200: preparing a conductive element: fixing at least two conductive contacts on a circuit board integrated with a detection circuit, wherein the number of the conductive contacts is the same as the number of the conductive contact points.

[0094] Preferably, see Figure 4 , the fixing of at least two conductive contacts on a circuit board integrated with a detection circuit comprises:

[0095] At least two bases 62 are fixed on the circuit board 50. The bases 62 are provided with elastic keys 64, and the elastic keys are provided with conductive contacts 66. The elastic keys 64 may be springs.

[0096] S300: Assembling: inserting the circuit board provided with the conductive element into the housing so that the conductive contacts abut against the conductive contacts one by one, thereby realizing electrical connection between the detection circuit and the detection electrode.

[0097] Preferably, see Figure 5 and Figure 6The housing 10 includes a housing body 101 and a housing cap 102. Before the circuit board 50 provided with the conductive element 60 is inserted into the housing 10, the following steps are further included:

[0098] Prepare a connector 40 : The connector 40 is used to connect with one end of the circuit board 50 facing the shell cap 102 , and an accommodating space 42 is provided at one end of the connector 40 away from the circuit board 50 .

[0099] Prepare the shell cap 102: A protrusion 70 is provided on the side of the shell cap 102 facing the circuit board 50, and the protrusion 70 includes a connecting rod 71 connected to the shell cap 102, and a protrusion 72 connected to the end of the connecting rod 71, and the protrusion 72 can be placed in the accommodating space 42 to make the protrusion 70 and the accommodating space 42 movably cooperate, and the shell cap 102 can pull the circuit board 50 along the length direction of the shell 10.

[0100] The circuit board 50 , the connector 40 , and the shell cap 102 are assembled and connected and then inserted into the shell body 101 .

[0101] For example, the circuit board 50 may be first connected to the connector 40 and then to the shell cap 102; or the shell cap 102 may be first connected to the connector 40 and then to the circuit board 50. Inserting the circuit board 50 into the circuit board groove of the shell body 101 can achieve stable buckling of the circuit board 50 to maintain structural stability; on the other hand, it can fix the position of the circuit board 50 so that it can better contact with the detection electrode 20 to achieve electrical connection. The fully implantable sensor 100 can be assembled by tightening the shell cap 102.

[0102] S400: Sealed.

[0103] Specifically, after the shell body 101 and the shell cap 102 are assembled, a sealing material may be coated on the shell cap 102 end of the fully implantable sensor 100 to seal the gap between the shell body 101 and the shell cap 102 to prevent tissue fluid from entering the interior of the sensor and affecting its performance.

[0104] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present application, rather than to limit it. Although the present application has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present application.

[0105] In addition, those skilled in the art will appreciate that, although some embodiments herein include certain features included in other embodiments but not other features, the combination of features of different embodiments is meant to be within the scope of the present application and form different embodiments. For example, in the above claims, any one of the claimed embodiments may be used in any combination. The information disclosed in this background technology section is intended only to deepen the understanding of the overall background technology of the present application and should not be regarded as an admission or in any form of implication that the information constitutes prior art known to those skilled in the art.

Claims

1. A reusable fully implantable sensor, characterized in that: include: A housing (10), wherein a detection electrode (20) is arranged on the housing (10), and a circuit board (50) is arranged inside the housing (10), wherein the housing (10) comprises a housing body (101) and a housing cap (102), wherein the circuit board (50) is arranged inside the housing body (101), and wherein a connecting piece (40) is provided to connect the circuit board (50) and the housing cap (102), wherein the connecting piece (40) and the circuit board (50) are detachably connected, and wherein the circuit board (50) is integrated with a detection circuit; A conductive element (60) for electrically connecting the detection circuit and the detection electrode (20), the conductive element (60) comprising: A base (62), the base (62) being fixed on the circuit board (50); An elastic key (64), wherein the elastic key (64) is arranged in the base (62); A conductive contact (66) disposed on the elastic key (64); The elastic key (64) is a spring; The fully implantable sensor further comprises: At least two conductive contacts (12) are arranged on the housing (10), the number of the conductive contacts (12) corresponds to the number of the conductive contacts (66), and the detection electrodes (20) are independently covered on the at least two conductive contacts (12); The conductive contact (66) abuts against the conductive contact point (12) to achieve electrical connection between the detection circuit and the detection electrode (20).

2. The reusable fully implantable sensor according to claim 1, characterized in that: The connecting member (40) is connected to one end of the circuit board (50) facing the shell cap (102), and an accommodating space (42) is provided at one end of the connecting member (40) away from the circuit board (50); A protrusion (70) is provided on a side of the shell cap (102) facing the circuit board (50); the protrusion (70) comprises a connecting rod (71) connected to the shell cap (102), and a protrusion (72) connected to the end of the connecting rod (71); the protrusion (72) can be placed in the accommodating space (42) so that the protrusion (70) and the accommodating space (42) can be flexibly matched, and the shell cap (102) can pull the circuit board (50) along the length direction of the shell body.

3. The reusable fully implantable sensor according to claim 2, characterized in that: A snap-in (43) is provided on one side of the accommodating space (42) facing the shell cap (102), and the protrusion is placed in the accommodating space (42) through the snap-in (43), and the width of the snap-in (43) is smaller than the width of the protrusion (72), so that when the shell cap (102) pulls the circuit board (50) along the length direction of the shell body, the protrusion (72) can be stuck at the snap-in (43) and does not fall off.

4. The reusable fully implantable sensor according to claim 3, characterized in that: The connecting member (40) is further provided with a placement opening (44), the placement opening (44) being in communication with the accommodating space (42), the bayonet (43) being a U-shaped opening formed on the end surface of the connecting member (40), the placement opening (44) being integrated with the U-shaped opening, and the width of the placement opening (44) being greater than the width of the bayonet (43), so that the protrusion (72) can be freely taken in and out through the placement opening (44).

5. A method for preparing a reusable fully implantable sensor according to any one of claims 1 to 4, characterized in that: include: Preparing detection electrodes: arranging at least two conductive contacts on the housing, and arranging detection electrodes on the at least two conductive contacts respectively; Prepare the conductive element: fix at least two conductive contacts on the circuit board integrated with the detection circuit, the number of the conductive contacts being the same as the number of the conductive contact points; Assembling: inserting the circuit board provided with the conductive element into the housing so that the conductive contacts abut against the conductive contacts one by one, thereby realizing electrical connection between the detection circuit and the detection electrode; seal; The method of fixing at least two conductive contacts on a circuit board integrated with a detection circuit comprises: At least two bases are fixed on the circuit board, wherein elastic keys are arranged in the bases, and conductive contacts are arranged on the elastic keys; The housing comprises a housing body and a housing cap, the circuit board is arranged in the housing body, and before the circuit board provided with the conductive element is inserted into the housing, the method further comprises: Prepare a connector: The connector connects the circuit board and the shell cap, and the connector and the circuit board are detachably connected; The circuit board, the connector and the shell cap are assembled and connected and then inserted into the shell body.

6. The preparation method according to claim 5, characterized in that: The step of respectively arranging detection electrodes on the at least two conductive contacts comprises: Preparing a conductive coating on the housing, wherein the conductive coating covers the at least two conductive contacts; Cutting the conductive coating into at least two separate parts, so that each part of the conductive coating covers one of the conductive contacts; providing an electrode layer on any portion of the conductive coating layer as a counter electrode; An enzyme layer is disposed on at least a portion of the conductive coating outside the counter electrode as a working electrode.

7. The preparation method according to claim 5, characterized in that: The connecting member is used to connect with one end of the circuit board facing the shell cap, and an accommodating space is provided at one end of the connecting member away from the circuit board; A protrusion is provided on the side of the shell cap facing the circuit board, and the protrusion includes a connecting rod connected to the shell cap, and a protrusion connected to the end of the connecting rod. The protrusion can be placed in the accommodating space so that the protrusion can be flexibly matched with the accommodating space, and the shell cap can pull the circuit board along the length direction of the shell.

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