Kit
By designing the runner and flow holes in the reagent kit, the sealing absorption of the reagent is achieved, and the problems of cleaning difficulty and increased liquid consumption caused by inserting the reagent needle into the deep tank in the prior art are solved, and the effect of miniaturization and convenient operation of the reagent needle is achieved.
Patent Information
- Application Number
- CN202110547036.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2021-05-19
- Publication Date
- 2025-06-27
- Estimated Expiration
- 2041-05-19
AI Technical Summary
When the reagent tank of the existing kit is deeper, the reagent needle needs to be inserted deeper, which increases the difficulty of cleaning and the amount of cleaning solution. At the same time, all the reagents attached to the outer wall of the reagent needle need to be cleaned, which increases the complexity of operation.
A reagent kit is designed, including a box body, a top cover body and a side cover body. A multiple reagent tank and flow hole are provided in the box body. The flow path plate and the side cover body are arranged together to form a flow channel. A sealed state can be formed in the flow channel. The reagent needle can be inserted into the first liquid suction port, and the reagent can be driven into the flow channel through the flow hole and then be absorbed.
The difficulty of cleaning the reagent needle and the amount of cleaning solution are reduced, and the need for reagent needles to be inserted into the bottom of the reagent tank is avoided, making the reagent needles smaller and more convenient to operate.
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Figure CN115367255B_ABST
Abstract
Description
Technical Field
[0001] This application relates to the field of biochemical detection, and particularly to a reagent kit. Background Art
[0002] In the field of biochemistry, it is usually necessary to use a variety of different reagents to detect biological samples. Operators need to prepare various reagents, reagent tubes, and other auxiliary tools in advance before they can perform the detection. The reagent kit is provided with a plurality of independent reagent slots, and various required reagents can be centrally placed. The operator only needs to insert a reagent needle into the corresponding reagent slot to suck out the required reagent, thus facilitating the detection.
[0003] However, the reagent needle needs to be inserted to the bottom of the reagent slot to maximize the utilization of the reagent in the reagent slot. Therefore, when the reagent slot is relatively deep, the length of the reagent needle also needs to be increased accordingly, and it will result in a larger insertion stroke of the reagent needle. Moreover, after the reagent needle is inserted to the bottom of the reagent slot, a large area of the outer wall of the reagent needle will be soaked in the reagent. When it is necessary to suck out the next different type of reagent, all the reagents attached to the outside of the reagent needle need to be washed off, which increases the amount of cleaning liquid used and the cleaning difficulty to a certain extent. Summary of the Invention
[0004] To solve the above deficiencies of the prior art, it is necessary to provide a reagent kit.
[0005] This application provides a reagent kit, including a box body, a top cover body, and a side cover body. The box body includes a bottom wall and a plurality of side walls arranged around the edge of the bottom wall. The side walls and the bottom wall jointly enclose a containing space, and the containing space includes a plurality of reagent slots for loading reagents. One of the side walls is provided with a plurality of through holes, and each through hole communicates with one of the reagent slots. The outer surface of the side wall having the through holes is further convexly provided with a plurality of flow channel plates. The top cover body is provided at one end of the plurality of side walls away from the bottom wall, and the top cover body is used to close the containing space. The top cover body is provided with a plurality of first liquid suction ports. The side cover body is provided on the side of the flow channel plate away from the side wall. Each flow channel plate, the side wall, and the side cover body jointly enclose a flow channel, and the flow channel communicates the through hole and the first liquid suction port, and communicates with the corresponding reagent slot through the through hole. A sealed state can be formed in the flow channel.
[0006] In some possible implementations, the box body further includes an extension plate, which protrudes from the outer surface of the side wall having the circulation holes and is disposed between the top cover body and the flow channel plate. Each flow channel plate is connected to the extension plate, and a plurality of second liquid suction ports are provided on the extension plate. The second liquid suction ports communicate between the first liquid suction port and the flow channel. A first sealing member is provided between the top cover body and the extension plate. The first sealing member is provided with a plurality of protruding portions, and the protruding portions extend into the second liquid suction ports. The protruding portions are used to form a sealed state in the flow channel.
[0007] In some possible implementations, the box body further includes an extension plate,
[0008] The side cover body includes a first cover body portion and a second cover body portion connected to the first cover body portion. The first cover body portion is disposed on the side of the flow channel plate away from the side wall, and the second cover body portion is disposed between the top cover body and the extension plate. The second cover body portion is provided with a plurality of third liquid suction ports, and each third liquid suction port communicates between the first liquid suction port and the second liquid suction port.
[0009] In some possible implementations, each flow channel plate includes a bottom portion and side portions connected to both sides of the bottom portion. The bottom portion is disposed close to the bottom wall, and the side portions are connected to the extension plate. The bottom portion, the two side portions, the extension plate, the side wall, and the side cover body of each flow channel plate jointly enclose to form the flow channel.
[0010] In some possible implementations, a second sealing member is provided between the flow channel plate and the side cover body. The second sealing member is used to form a sealed state in the flow channel.
[0011] In some possible implementations, the accommodation space includes a first region, and a plurality of first partition plates are provided in the first region. The first partition plates are used to divide the first region into the reagent grooves.
[0012] In some possible implementations, the accommodation space further includes a second region, and a plurality of second partition plates are provided in the second region. The second partition plates are used to divide the second region into a plurality of premixing grooves for pre-storing reagents. A premixing bottle for pre-storing another reagent is provided in each premixing groove, and a puncturing member is further provided in the premixing bottle. The puncturing member is used to pierce the bottom of the premixing bottle when pressed.
[0013] In some possible implementations, a third sealing member is provided between the inner wall of the premixing bottle and the puncturing member. The third sealing member is used to seal the gap between the inner wall of the premixing bottle and the puncturing member.
[0014] In some possible implementations, a pressing portion is provided on the top cover body, the pressing portion is arranged corresponding to the puncturing member, and the pressing portion is used to push the puncturing member after being pressed.
[0015] In some possible implementations, a retaining piece is provided on the top cover body, the retaining piece is arranged between the pressing portion and the puncturing member, a sliding groove is further provided on the top cover body, and a part of the retaining piece is exposed from the sliding groove and can slide in the sliding groove. The retaining piece can switch between a first state and a second state when sliding, the first state is that the retaining piece does not block the puncturing member, and the second state is that the retaining piece blocks the puncturing member.
[0016] Compared with the prior art, in the present application, when it is necessary to aspirate a reagent, the reagent needle can be inserted (or the pipeline can be connected) into the first liquid suction port. Since a sealed state can be formed in the flow channel, with the aspiration action of the reagent needle (or pipeline), the reagent in the reagent tank can be driven to flow into the flow channel through the through hole, and then be aspirated by the reagent needle (or pipeline), avoiding the situation that the reagent needle needs to be inserted into the bottom of the reagent tank to maximize the utilization of the reagent in the reagent tank. Therefore, the present application is beneficial to reducing the cleaning difficulty of the reagent needle and the amount of cleaning liquid used for cleaning, and is also beneficial to making the reagent needle more miniaturized. BRIEF DESCRIPTION OF THE DRAWINGS
[0017] Figure 1 It is a schematic structural diagram of a reagent kit provided by an embodiment of the present application.
[0018] Figure 2 is Figure 1 an exploded view of the shown reagent kit.
[0019] Figure 3 is Figure 1 a sectional view of the shown reagent kit along III-III.
[0020] Figure 4 is Figure 1 a sectional view of the shown reagent kit along IV-IV.
[0021] MAIN ELEMENT SYMBOL DESCRIPTION
[0022] Cartridge body 10
[0023] Bottom wall 11
[0024] Side wall 12
[0025] First partition 13
[0026] Flow channel plate 14
[0027] Extension plate 15
[0028] Second partition 16
[0029] Premixing bottle 17
[0030] Piercing member 18
[0031] Top cover body 20
[0032] Liquid filling port 21
[0033] First liquid suction port 22
[0034] Pressing part 23
[0035] Blocking piece 24
[0036] Side cover body 30
[0037] First cover body part 31
[0038] Second cover body part 32
[0039] Second seal 40
[0040] First seal 50
[0041] Protruding part 51
[0042] Third seal 60
[0043] Reagent kit 100
[0044] Flow-through hole 120
[0045] First side 131
[0046] Second side 132
[0047] Flow channel 140
[0048] Bottom 141
[0049] Side part 143
[0050] Second liquid suction port 150
[0051] Chute 200
[0052] Connection end 231
[0053] Free end 232
[0054] Third liquid suction port 320
[0055] Accommodation space 1000
[0056] First area 1001
[0057] Second area 1002
[0058] Reagent tank 1003
[0059] Premixing tank 1004
[0060] The following specific embodiments will further illustrate the present application in conjunction with the above-mentioned drawings. Specific embodiments
[0061] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments.
[0062] It should be noted that when a component is considered to be "disposed on" another component, it can be directly disposed on the other component or there may be an intermediate component at the same time; when a component is considered to be "mounted on" another component, it can be directly mounted on the other component or there may be an intermediate component at the same time. The term "and / or" used herein includes all and any combinations of one or more of the related listed items.
[0063] Please refer to Figure 1 and Figure 2 As shown, an embodiment of the present application provides a kit 100 for loading various reagents required in the biochemical detection process. The kit 100 includes a box body 10, a top cover body 20 and a side cover body 30.
[0064] The box body 10 includes a bottom wall 11 (shown in Figure 3 ), a plurality of side walls 12 and a plurality of first partitions 13. The side walls 12 are disposed around a plurality of edges of the bottom wall 11, so that the side walls 12 and the bottom wall 11 jointly enclose a receiving space 1000. Among them, the receiving space 1000 is divided into a first region 1001 and a second region 1002.
[0065] A plurality of first partitions 13 are disposed in the first region 1001 of the receiving space 1000 for dividing the first region 1001 into a plurality of independent reagent tanks 1003. Each reagent tank 1003 is used to store a reagent. In some embodiments, the volumes of the plurality of reagent tanks 1003 are different from each other, so that the plurality of reagent tanks 1003 can be respectively used to store reagents of different volumes. Therefore, in actual use, according to the amount of a certain reagent required in the biochemical process, the reagent can be loaded into the corresponding reagent tank 1003. In some embodiments, each first partition 13 can be non-planar or planar, and each first partition 13 includes opposite first side edges 131 and second side edges 132. The first side edges 131 of the plurality of first partitions 13 are all connected to one of the side walls 12, and the second side edges 132 of the plurality of first partitions 13 are respectively connected to the other side walls 12, so that the plurality of first partitions 13 are radially distributed outward from one of the side walls 12.
[0066] The top cover body 20 is provided at one end of the plurality of side walls 12 away from the bottom wall 11. The top cover body 20 is used to close the accommodation space 1000, thereby reducing the risk of the reagent overflowing from the reagent tank 1003 and also playing a protective role. In some embodiments, a plurality of liquid adding ports 21 are provided on the top cover body 20, and each liquid adding port 21 corresponds to a reagent tank 1003. The user can add the reagent into the corresponding reagent tank 1003 through the liquid adding port 21, and the atmosphere can flow into the reagent tank 1003 during use. Generally, a sealing film (not shown in the figure) is provided at the opening of the accommodation space 1000, and the sealing film needs to be punctured when adding the reagent into the corresponding reagent tank 1003 or allowing the atmosphere to flow into the reagent tank 1003.
[0067] Please refer to Figure 2 and Figure 3 , at least one of the plurality of side walls 12 is provided with a plurality of flow holes 120 arranged at intervals, and each flow hole 120 communicates with one of the reagent tanks 1003. The outer surface of the side wall 12 having the flow holes 120 further protrudes with a plurality of flow channel plates 14. The side cover body 30 is provided on the side of the flow channel plate 14 away from the side wall 12. Each flow channel plate 14, side wall 12 and side cover body 30 jointly enclose to form a flow channel 140. A plurality of first liquid suction ports 22 are provided on the top cover body 20, and the flow channel 140 communicates with a flow hole 120 and a first liquid suction port 22. The volume of the flow channel 140 can be smaller than the volume of the corresponding reagent tank 1003, and a sealed state can be formed in the flow channel 140. In some embodiments, the flow holes 120 can be arranged adjacent to the bottom wall 11.
[0068] Therefore, when it is necessary to suck the reagent, the reagent needle (not shown in the figure) can be inserted into the first liquid suction port 22. Since a sealed state is formed in the flow channel 140, with the sucking action of the reagent needle, the reagent in the reagent tank 1003 can be driven to flow into the flow channel 140 through the flow hole 120 and then be sucked by the reagent needle, avoiding the situation that the reagent needle needs to be inserted into the bottom of the reagent tank 1003 to maximize the utilization of the reagent in the reagent tank 1003. Therefore, this application is beneficial to reducing the cleaning difficulty of the reagent needle and the amount of cleaning liquid used for cleaning, and is also beneficial to making the reagent needle more miniaturized. In the present invention, the reagent needle can be made very short or even not designed, as long as a pipeline capable of being connected to the liquid suction port is designed.
[0069] In some embodiments, an extension plate 15 protrudes from the outer surface of the side wall 12 having the circulation holes 120. The extension plate 15 is disposed between the top cover body 20 and the flow channel plate 14, and each flow channel plate 14 is connected to the extension plate 15. A plurality of second liquid suction ports 150 are provided on the extension plate 15 at intervals. The second liquid suction ports 150 communicate between the first liquid suction port 22 and the flow channel 140. In some embodiments, each flow channel plate 14 includes a bottom 141 and side portions 143 connected to both sides of the bottom 141. The bottom 141 can be disposed close to the bottom wall 11, and the side portions 143 are connected to the extension plate 15. The bottom 141, two side portions 143, the extension plate 15, the side wall 12, and the side cover body 30 of each flow channel plate 14 together enclose to form the flow channel 140.
[0070] A first seal 50 is further provided between the top cover body 20 and the extension plate 15. The first seal 50 is provided with a plurality of protruding portions 51 through which a reagent needle (or a pipe) can pass, and the protruding portions 51 extend into the second liquid suction ports 150. The protruding portions 51 are used to seal the gap between the second liquid suction ports 150 and the reagent needle (or the pipe) when the reagent needle (or the pipe) is inserted into the first liquid suction port 22 and the second liquid suction port 150 in sequence, so as to form a sealed state in the flow channel 140, facilitating the suction of the reagent in the flow channel 140.
[0071] In some embodiments, the side cover body 30 includes a first cover portion 31 and a second cover portion 32 connected to the first cover portion 31. The first cover portion 31 is disposed on the side of the flow channel plate 14 away from the side wall 12. The second cover portion 32 can be substantially perpendicular to the first cover portion 31, and the second cover portion 32 is disposed between the top cover body 20 and the first seal 50. The second cover portion 32 is provided with a plurality of third liquid suction ports 320, and each third liquid suction port 320 communicates between the first liquid suction port 22 and the second liquid suction port 150. At this time, the reagent needle (or the pipe) can be inserted into the first liquid suction port 22, the third liquid suction port 320, and the second liquid suction port 150 in sequence, so as to suck the reagent in the flow channel 140.
[0072] In some embodiments, a second seal 40 is provided between the flow channel plate 14 and the side cover body 30. The second seal 40 is used to seal the gap between the edge of the flow channel plate 14 away from the side wall 12 and the side cover body 30, so as to maintain the sealed state in the flow channel 140 and ensure that the reagents between different flow channels 140 do not mix with each other.
[0073] Please refer to Figure 2 and Figure 4, in some embodiments, a plurality of second partition plates 16 are provided in the second region 1002. The second partition plates 16 are used to divide the second region 1002 into a plurality of premixing tanks 1004. Generally, reagents are pre-stored in the premixing tanks 1004. At least one premixing bottle 17 is provided in each premixing tank 1004, and another reagent is pre-stored in the premixing bottle 17. A piercing member 18 is further provided in each premixing bottle 17. The piercing member 18 is used to pierce the bottom of the premixing bottle 17 when pressed, so that the pre-stored reagent in the premixing bottle 17 flows out into the premixing tank 1004, thereby mixing the two reagents. In some embodiments, the bottom of the premixing bottle 17 may be a film layer that is easy to pierce. The piercing member 18 may be a piercing plunger.
[0074] Furthermore, a third sealing member 60 may be provided between the inner wall of the premixing bottle 17 and the piercing member 18. The third sealing member 60 is used to seal the gap between the inner wall of the premixing bottle 17 and the piercing member 18, thereby reducing the risk of the reagent in the premixing bottle 17 overflowing upward between the inner wall of the premixing bottle 17 and the piercing member 18. The third sealing member 60 may be an O-ring.
[0075] Furthermore, as Figure 1 and Figure 2 shown, at least one pressing portion 23 may be provided on the top cover body 20, and each pressing portion 23 is provided corresponding to the piercing member 18 in one of the premixing bottles 17. The pressing portion 23 includes a connecting end 231 connected to the top cover body 20 and a free end 232 opposite to the connecting end 231. When the user presses the pressing portion 23, the free end 232 of the pressing portion 23 moves toward the piercing member 18, thereby pushing the piercing member 18 to pierce the bottom of the premixing bottle 17.
[0076] Furthermore, at least one baffle 24 is further provided on the top cover body 20, and each baffle 24 is disposed between one of the pressing portions 23 and the corresponding piercing member 18. The baffle 24 can be switched between a first state and a second state when the user operates. The first state is that the baffle 24 does not block the piercing member 18, so that after the pressing portion 23 is pressed, it can push the piercing member 18 to pierce the bottom of the premixing bottle 17. The second state is that the baffle 24 blocks the piercing member 18, so that after the pressing portion 23 is pressed, it is blocked by the baffle 24, and thus cannot push the piercing member 18 to pierce the bottom of the premixing bottle 17. Therefore, when the premixing of reagents is not required, the baffle 24 can be operated to switch to the second state, thereby reducing the risk of the piercing member 18 being accidentally pressed and piercing the bottom of the premixing bottle 17.
[0077] Among them, a sliding groove 200 may be provided on the top cover body 20, and the baffle 24 may be partially exposed from the sliding groove 200 for the user to operate. For example, when the user pushes the partial baffle 24 exposed from the sliding groove 200 to slide back and forth in the sliding groove 200, the baffle 24 can be switched between the first state and the second state.
[0078] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present application and not to limit them. Although the present application has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present application can be modified or equivalently replaced without departing from the spirit and scope of the technical solutions of the present application.
Claims
1. A kit, characterized in that, Comprising: A box body, including a bottom wall and a plurality of side walls arranged around the edge of the bottom wall, the side walls and the bottom wall jointly enclosing a containing space, the containing space including a plurality of reagent grooves for loading reagents; a plurality of flow holes are provided on one of the side walls, each flow hole communicating with one of the reagent grooves, and a plurality of flow channel plates are further convexly provided on the outer surface of the side wall having the flow holes; A top cover body, provided at one end of the plurality of side walls away from the bottom wall, the top cover body being used to close the containing space, a plurality of liquid adding ports and a plurality of first liquid suction ports are provided on the top cover body, each liquid adding port corresponding to one of the reagent grooves, and the liquid adding port is used to add reagents into the reagent grooves; And A side cover body, provided on the side of the flow channel plate away from the side wall, each flow channel plate, the side wall and the side cover body jointly enclosing a flow channel, the flow channel communicating the flow hole and the first liquid suction port and communicating with the corresponding reagent groove through the flow hole, a sealed state can be formed in the flow channel, and the first liquid suction port is used to suck the reagent flowing into the flow channel through the flow hole.
2. The kit according to claim 1, wherein The box body further includes an extension plate, the extension plate being convexly provided on the outer surface of the side wall having the flow holes and being provided between the top cover body and the flow channel plate, each flow channel plate being connected to the extension plate, and a plurality of second liquid suction ports are provided on the extension plate, the second liquid suction ports being communicated between the first liquid suction port and the flow channel; A first sealing member is provided between the top cover body and the extension plate, a plurality of protruding portions are provided on the first sealing member, the protruding portions extending into the second liquid suction ports, and the protruding portions are used to form a sealed state in the flow channel.
3. The kit according to claim 2, wherein The side cover body includes a first cover body portion and a second cover body portion connected to the first cover body portion, the first cover body portion being provided on the side of the flow channel plate away from the side wall, and the second cover body portion being provided between the top cover body and the extension plate; The second cover body portion is provided with a plurality of third liquid suction ports, each third liquid suction port being communicated between the first liquid suction port and the second liquid suction port.
4. The kit according to claim 2, wherein Each flow channel plate includes a bottom and side portions connected to both sides of the bottom, the bottom being arranged close to the bottom wall, the side portions being connected to the extension plate, and the bottom, the two side portions, the extension plate, the side wall and the side cover body of each flow channel plate jointly enclosing the flow channel.
5. The kit according to claim 1, characterized in that, A second sealing member is provided between the flow channel plate and the side cover body, and the second sealing member is used to form a sealed state in the flow channel.
6. The kit according to claim 1, characterized in that, The containing space includes a first area, and a plurality of first partition plates are provided in the first area, and the first partition plates are used to divide the first area into the reagent grooves.
7. The kit according to claim 6, characterized in that, The containing space further includes a second area, and a plurality of second partition plates are provided in the second area, and the second partition plates are used to divide the second area into a plurality of premixing grooves for pre-storing reagents; A premixing bottle for pre-storing another reagent is provided in each premixing groove, and a piercing member is further provided in the premixing bottle, and the piercing member is used to pierce the bottom of the premixing bottle when being pressed.
8. The kit according to claim 7, wherein A third seal is provided between the inner wall of the premixing bottle and the piercing member, and the third seal is used to seal the gap between the inner wall of the premixing bottle and the piercing member.
9. The kit according to claim 7, wherein, A pressing portion is provided on the top cover body, the pressing portion is arranged corresponding to the piercing member, and the pressing portion is used to push the piercing member after being pressed.
10. The kit according to claim 9, characterized in that, A baffle is provided on the top cover body, the baffle is arranged between the pressing portion and the piercing member, a sliding groove is further provided on the top cover body, and part of the baffle is exposed from the sliding groove and can slide in the sliding groove; When the baffle slides, it can switch between a first state and a second state. The first state is that the baffle does not block the piercing member, and the second state is that the baffle blocks the piercing member.
Citation Information
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