A biochemical index detection method

Abstract

The application discloses a biochemical index detection method and device, which comprises a terminal with a capacitive touch screen, a detection film, a first wire and a first conductive electrode; the detection film is arranged on the capacitive touch screen of the terminal and is used for dropping a sample to be detected; and the first conductive electrode is connected with the detection film through the first wire. The application detects the ion concentration in the sample to be detected on the detection film through the detection film arranged on the capacitive touch screen of the terminal, can sensitively and quickly collect and feed back the capacitive signal change generated on the screen, can realize convenient and rapid detection and monitoring of conventional health indexes by building a reaction system coupled with the capacitive signal and collecting the signal change, thereby providing convenient biochemical index detection, reducing the test cost, realizing the goal of self-checking of related health detection indexes at home, avoiding the situation of high complexity and low detection efficiency of the detection equipment, and optimizing the use experience of users.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical detection, in particular to a biochemical index detection method. BACKGROUND

[0002] At present, most of the biochemical index detection needs to be sent to the laboratory for testing, which requires the support of large detection equipment and a long waiting time, resulting in that the index information cannot be obtained conveniently and quickly in the conventional physical examination and disease screening, which seriously delays the diagnosis and treatment of the disease.

[0003] Therefore, there is an urgent need for a biochemical index detection device that can simplify the complexity of the detection equipment and improve the detection efficiency. SUMMARY

[0004] The present application provides a biochemical index detection device to solve the technical problems of complex detection equipment and low detection efficiency in the prior art.

[0005] In order to solve the above technical problems, the present application provides a biochemical index detection device, comprising: a terminal with a capacitive touch screen, a detection film, a first wire and a first conductive electrode;

[0006] The detection film is arranged on the capacitive touch screen of the terminal and is used for dropping the sample to be detected.

[0007] The first conductive electrode is connected to the detection film through the first wire.

[0008] As a preferred scheme, it further comprises a second wire and a second conductive electrode.

[0009] The second conductive electrode is connected to the detection film through the second wire.

[0010] As a preferred scheme, the thickness of the detection film is less than 2mm.

[0011] As a preferred scheme, the material of the detection film comprises a high polymer material and a glass material, wherein the high polymer material comprises one or more of polypropylene, polyethylene, polyvinyl chloride, polystyrene, polyethylene terephthalate and polymethyl methacrylate.

[0012] Correspondingly, the present application also provides a biochemical index detection method, which is executed by a user and realized through the above-mentioned biochemical index detection device, comprising the following steps:

[0013] Turning on the touch screen signal feedback module of the terminal;

[0014] Dropping the sample to be detected onto the detection film on the capacitive touch screen of the terminal;

[0015] The contact detection trigger device triggers the terminal to feed back a value after processing the sample to be detected, and the value is taken as a detection result.

[0016] As a preferred solution, the contact detection trigger device triggers the terminal to feed back a value after processing the sample to be detected, and the value is taken as a detection result, and the contact detection trigger device further comprises:

[0017] The first conductive electrode and the second conductive electrode are arranged separately, and one of the conductive electrodes is contacted to obtain a first detection result.

[0018] The first conductive electrode and the second conductive electrode are completely attached, and the first conductive electrode and the second conductive electrode are contacted to obtain a second detection result, so that the terminal processes the first detection result and the second detection result to obtain a real detection result.

[0019] Correspondingly, the application further provides a biochemical index detection method, which is executed by the terminal with the capacitive touch screen in the biochemical index detection device, and comprises the following steps:

[0020] In response to the user dropping the sample to be detected and contacting the detection trigger device, the touch screen signal feedback module detects an initial capacitance value in the capacitive touch screen.

[0021] The initial capacitance value is eliminated to obtain a total amount of effective data.

[0022] According to the total amount of effective data and the capacitance value corresponding to the effective data, a unit capacitance average value is obtained.

[0023] By comparing with a preset reference value corresponding table, a detection result of the sample to be detected is obtained.

[0024] As a preferred solution, the method further comprises:

[0025] In response to the user selecting a detection item, a preset reference value corresponding table corresponding to the detection item selected by the user is called; wherein the preset reference value corresponding table comprises a corresponding relationship between each concentration of ions corresponding to the detection item in the sample to be detected and a unit capacitance value.

[0026] As a preferred solution, the method further comprises:

[0027] In response to the user separately arranging the first conductive electrode and the second conductive electrode and contacting one of the conductive electrodes, a first detection result is recorded.

[0028] In response to the user fully adhering and contacting the first conductive electrode and the second conductive electrode, a second detection result is recorded;

[0029] According to the first detection result and the second detection result, a real detection result of ions corresponding to a detection item in the sample to be detected is obtained.

[0030] Compared with the prior art, the embodiment of the present application has the following beneficial effects:

[0031] The technical solution of the present application detects the ion concentration in the sample to be detected on the detection film by setting the detection film on the terminal capacitive touch screen. The capacitive touch screen has the characteristics of high popularity, high sensitivity, and high throughput, and can sensitively and quickly collect and feedback the capacitive signal changes generated on the screen. The capacitive signal changes can be applied to the detection of biochemical indicators. By building a reaction system coupled with the capacitive signal, the signal changes can be collected to realize convenient and rapid detection and monitoring of conventional health indicators, thereby providing convenient biochemical indicator detection, reducing testing costs, realizing the goal of self-testing of related health detection indicators at home, avoiding the complexity of detection equipment and low detection efficiency, and optimizing the user experience. BRIEF DESCRIPTION OF DRAWINGS

[0032] Figure 1 Fig. 1 is a structural schematic diagram of a biochemical indicator detection device provided by an embodiment of the present application;

[0033] Figure 2 Fig. 2 is a structural schematic diagram of a biochemical indicator detection device provided by another preferred embodiment of the present application;

[0034] Figure 3 Fig. 3 is a step flowchart of a biochemical indicator detection method performed by a user according to an embodiment of the present application;

[0035] Figure 4 Fig. 4 is a step flowchart of a biochemical indicator detection method performed by a terminal according to an embodiment of the present application;

[0036] Figure 5 Fig. 5 is a schematic diagram of capacitive value data detection of a capacitive touch screen under different sample concentrations according to an embodiment of the present application;

[0037] Figure 6 Fig. 6 is a relationship diagram between the unit capacitive mean value in the capacitive screen feedback data and the sample ion concentration according to an embodiment of the present application;

[0038] Figure 7 Fig. 7 is a step flowchart of calling an item in the biochemical indicator detection method performed by the terminal according to an embodiment of the present application;

[0039] Figure 8A biochemical index detection step flow chart in a uric acid detection item provided by the embodiment of the present application;

[0040] In the drawings of the specification, the reference signs are as follows:

[0041] Terminal 1, detection film 2, sample to be detected 3, first lead wire 4, first conductive electrode 5, second lead wire 6, and second conductive electrode 7. DETAILED DESCRIPTION

[0042] The technical solutions in the embodiments of the present application will be clearly and completely described in combination with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the protection scope of the present application.

[0043] Embodiment one

[0044] Please refer to Figure 1 The biochemical index detection device provided by the embodiment of the present application comprises a terminal 1 with a capacitive touch screen, a detection film 2, a first lead wire 4, and a first conductive electrode 5.

[0045] It should be noted that the terminal 1 is preferably a mobile phone. The capacitive touch screen of the mobile phone has the characteristics of high popularity, high sensitivity, and high throughput, and can sensitively and quickly collect and feedback the capacitive signal change generated on the screen. By using the characteristics of the capacitive touch screen, the capacitive touch screen can be applied to the detection of biochemical indexes. By building a reaction system coupled with the capacitive signal, the signal change thereof can be collected to realize convenient and rapid detection and monitoring of routine health indexes.

[0046] The detection film is arranged on the capacitive touch screen of the terminal 1 and is used for dropping the sample to be detected 3. The first conductive electrode 5 is connected to the detection film 2 through the first lead wire 4.

[0047] It should be noted that the types of the sample to be detected 3 include body fluids such as saliva, serum, and urine. The specific detection indexes include uric acid, glucose, pH value, total bacteria content, and specific fragment nucleic acid.

[0048] As a preferred scheme of the embodiment, please refer to Figure 2 The biochemical index detection device of the embodiment further comprises a second lead wire 6 and a second conductive electrode 7. The second conductive electrode 7 is connected to the detection film 2 through the second lead wire 6.

[0049] As a preferred scheme of the embodiment, the thickness of the detection film 2 is less than 2 mm.

[0050] As a preferred scheme of the embodiment, the material of the detection film 2 includes a polymer material and a glass material, wherein the polymer material includes one or more of polypropylene, polyethylene, polyvinyl chloride, polystyrene, polyethylene terephthalate, and polymethyl methacrylate.

[0051] It should be noted that the detection film 2 as the detection area in the biochemical index detection device of the embodiment has the structural feature that it can completely fit the capacitive screen, and the material of the detection film 2 is one or more of polypropylene, polyethylene, polyvinyl chloride, polystyrene, polyethylene terephthalate, and polymethyl methacrylate, or a glass material. In addition, the material of the detection film 2 is different for different sample types.

[0052] The above embodiment has the following effects:

[0053] The technical scheme of the present application detects the ion concentration in the sample to be detected on the detection film arranged on the capacitive touch screen of the terminal, and uses the characteristics of high popularity, high sensitivity, and high throughput of the capacitive touch screen to sensitively and quickly collect and feed back the capacitive signal change generated on the screen. The capacitive signal change can be applied to the detection of biochemical indexes. By building a reaction system coupled with the capacitive signal, the signal change can be collected to realize convenient and rapid detection and monitoring of conventional health indicators. Thus, the present application provides convenient biochemical index detection, reduces the testing cost, realizes the goal of self-testing of related health detection indicators at home, avoids the situation of complex detection equipment and low detection efficiency, and optimizes the user experience.

[0054] Embodiment two

[0055] Please refer to Figure 3 The present embodiment also provides a biochemical index detection method, which is executed by a user and realized by the biochemical index detection device in the above embodiment one, and includes the following steps S101-S103.

[0056] S101: Turn on the touch screen signal feedback module of the terminal.

[0057] S102: Drop the sample to be detected on the detection film of the capacitive touch screen of the terminal.

[0058] S103: Contact the detection trigger device until the terminal screen feeds back the value after processing the sample to be detected, and take the value as the detection result; wherein the detection trigger device includes a first conductive electrode and a second conductive electrode.

[0059] In the embodiment, exemplarily, taking the total bacteria content as the detection index, the detection film in the detection area is a polypropylene sheet, and the detection triggering device (triggering area) is composed of electrodes, preferably, the electrodes in the triggering area are platinum sheets or silver sheets, and the two areas are connected through wires. In use, the detection area is placed on the capacitive screen of a mobile phone, then different concentrations of quantitative salt solution are added dropwise into the detection area, and the feedback data are recorded after triggering detection through the triggering area.

[0060] In the embodiment, exemplarily, taking the pH value detection as the detection index, the main material of the detection film in the detection area is a polyethylene terephthalate sheet, the surface of which is covered with a chemical deposition polyaniline thin layer, the detection triggering device (triggering area) is composed of one triggering electrode, and the two areas are connected through wires. In use, the detection area is placed on the capacitive screen of a mobile phone, then quantitative sample solution is added dropwise into the detection area, and the feedback data are recorded after triggering detection through the triggering area. Since the conductivity of polyaniline is not the same under different pH values, and there is a certain positive correlation between them, the pH value of the sample can be calculated by analyzing the feedback data of the capacitive screen.

[0061] As a preferred scheme of the embodiment, when the uric acid detection item is performed, the contact detection triggering device triggers the sample until the terminal screen feeds back the value after processing of the sample, and the value is taken as the detection result, and the method further comprises the following steps of:

[0062] The first conductive electrode and the second conductive electrode are placed separately, and one of the conductive electrodes is contacted, so that a first detection result is obtained; the first conductive electrode and the second conductive electrode are completely attached, and the first conductive electrode and the second conductive electrode are contacted, so that a second detection result is obtained; and the terminal processes the first detection result and the second detection result, and then a true detection result is obtained.

[0063] Specifically, when the uric acid detection item is performed, the detection film in the detection area is a glass sheet, a part of the surface of the glass sheet is used as a reaction electrode by covering conductive gel, and Prussian blue is used for modification, on the other hand, the detection area and the detection triggering device (triggering area) are connected through two wires, and each wire is connected to a different electrode, that is, the triggering area is composed of two independent electrodes. In use, the device detection area is placed on the capacitive screen of a mobile phone, the two electrodes in the triggering area are placed separately and do not contact each other, and then quantitative sample to be detected is added dropwise into the detection area, and first feedback data are recorded by contacting one of the electrodes in the triggering area for detection; then the two electrodes in the triggering area are completely attached to trigger the original cell reaction of uric acid in the sample, and then the second feedback data are recorded by contacting the triggering area for detection again, and the concentration of uric acid in the sample can be calculated by calculating the difference between the two data.

[0064] The embodiment of the application has the following effects:

[0065] The embodiment of the present application opens the touch screen signal feedback module in the terminal, and drops the sample to be detected on the detection film on the capacitive touch screen of the terminal, so that the user contacts the detection trigger device until the screen of the terminal feeds back the value after processing the sample to be detected, and the value is taken as the detection result. The embodiment simplifies the complexity of the existing terminal detection of the user, and does not require the user to go to a fixed medical institution. Only a terminal with a capacitive touch screen, preferably a mobile phone, can realize the detection of biochemical indexes, and the detection efficiency is greatly improved.

[0066] Embodiment three

[0067] Please refer to Figure 4 The embodiment of the present application also provides a biochemical index detection method, which is executed by the terminal with the capacitive touch screen in the above-mentioned biochemical index detection device, and includes the following steps S201-S204:

[0068] S201: In response to the user dropping the sample to be detected and contacting the detection trigger device, the touch screen signal feedback module detects the initial capacitance value in the capacitive touch screen.

[0069] In the embodiment, after the user drops the sample to be detected and contacts the detection trigger device, the touch screen signal feedback module controlled by the terminal detects the capacitance value of each region in the capacitive touch screen. The process is similar to that the user directly touches the capacitive touch screen to change the capacitance of the touched region of the capacitive touch screen. However, in the embodiment, the detection film contacts the capacitive touch screen. Therefore, when the sample solution of different concentrations is dropped on the detection film and contacts the detection trigger device, the ion concentration of the sample solution is different, which causes the difference in the conductivity of the sample solution, so that different capacitance values are generated in the covered region of the detection film, thereby achieving the detection purpose.

[0070] Exemplarily, taking the total bacteria content detection as an example, the unit average of the feedback data of the sample detection has good correlation with the ion concentration of the sample, so that the ion concentration of the sample can be calculated by detecting the capacitance data of the sample to be detected. On the other hand, the metabolites of bacteria include various ions, such as nitrate ions, which are the main metabolites of Escherichia coli. The increase in the number of Escherichia coli increases the ion content in urine, and the total bacteria content in the sample has a certain correlation with the conductivity. After calibration by a standard sample, the total bacteria content of the sample can be calculated. Figure 3 which is the specific result of the capacitive screen feedback data. From left to right, the ion concentrations of the samples are 0, 0.04, 0.08, 0.12 and 0.16 mol / L.

[0071] S202: The initial capacitance value is removed to obtain the total amount of effective data.

[0072] It should be noted that the position of the sample solution dripped by the user is not exactly the same for each detection, but is on the detection film, so after triggering the detection trigger device, the effective data amount is obtained by eliminating the capacitance data with a capacitance value change difference less than a preset value on the capacitive touch screen. Preferably, according to the actual detection needs and detection item requirements, the preset value is set to 20, that is, the data with a capacitance value > 20 is effective data. For example, refer to Table 1 below. Figure 5 For a concentration of 0 mol / L, the effective data amount is four; for a concentration of 0.04 mol / L, the effective data amount is six.

[0073] S203: Obtain the unit capacitance mean value according to the total amount of effective data and the capacitance value corresponding to the effective data.

[0074] It should be noted that the total value of the capacitance value data can be calculated according to the capacitance value corresponding to the effective data, and the unit capacitance mean value can be obtained according to the total amount of effective data, which is used to represent the corresponding value at this concentration. Please refer to Table 1 below, which is a table of different concentrations of salt solution and its capacitance value data processing.

[0075]

[0076] Further, refer to Figure 6 , which is a graph of the relationship between the unit capacitance mean value and the sample ion concentration in the capacitive screen feedback data, so that the reference value corresponding table of the sample ion and the unit capacitance mean value can be obtained according to the graph, which is the index and its reference value corresponding table of the total bacterial content test in this embodiment.

[0077] S204: Obtain the detection result of the sample to be detected by comparing with the preset reference value corresponding table.

[0078] It should be noted that by obtaining the unit capacitance mean value of the sample to be detected and the preset reference value corresponding table, the ion concentration of the sample to be detected can be obtained according to the relationship between the ion concentration and the unit capacitance mean value of the sample to be detected.

[0079] For example, for pH value detection, since the conductivity of polyaniline is not the same under different pH values, and there is a certain positive correlation between them, the pH value of the sample to be detected can be calculated by analyzing the capacitance value data fed back by the capacitive touch screen.

[0080] As a preferred scheme of the present embodiment, refer to Figure 7 , the biochemical index detection method further comprises the following steps S2011:

[0081] S2011: in response to the user-selected detection item, calling a preset reference value corresponding table corresponding to the user-selected detection item; wherein the preset reference value corresponding table comprises a corresponding relationship between each concentration of ions corresponding to the detection item in the to-be-detected sample and a unit capacitance value.

[0082] As a preferred scheme of the embodiment, please refer to Figure 8 When the uric acid detection item is performed, the biochemical index detection method further comprises the following steps S205-S207:

[0083] S205: in response to the user placing the first conductive electrode and the second conductive electrode separately and contacting one of the conductive electrodes, thereby recording the first detection result.

[0084] S206: in response to the user completely adhering the first conductive electrode and the second conductive electrode and contacting the first conductive electrode and the second conductive electrode, thereby recording the second detection result.

[0085] S207: obtaining the real detection result of ions corresponding to the detection item in the to-be-detected sample according to the first detection result and the second detection result.

[0086] It should be noted that, please refer to Figure 2 When the uric acid detection item is performed, when the uric acid detection item is performed, the detection film in the detection area is a glass sheet, a part of the surface of the glass sheet uses a conductive gel as a reaction electrode, and Prussian blue is used for modification, on the other hand, the detection area and the detection trigger device (trigger area) are connected by two wires, each wire is connected to a different electrode, that is, the trigger area is composed of two independent electrodes. When in use, first place the device detection area on the mobile phone capacitive screen, the two electrodes of the trigger area are placed separately and do not contact each other, then add a certain amount of to-be-detected sample to the detection area, and then contact one of the electrodes in the trigger area to detect and record the first feedback data; then completely adhere the two electrodes of the trigger area together to trigger the original cell reaction of uric acid in the sample, then contact the trigger area again to detect and record the second feedback data, and the difference between the two data can be calculated to calculate the concentration of uric acid in the sample.

[0087] The embodiment of the present application has the following effects:

[0088] The embodiment of the present application improves the accuracy of the capacitive screen detection, avoids the interference of invalid data on the biochemical detection, and simultaneously obtains the unit capacitance mean value according to the total amount of the effective data and the capacitance value corresponding to the effective data, and then compares the unit capacitance mean value with the preset reference value corresponding table to accurately and quickly obtain the detection result of the sample to be detected, thereby avoiding the need for the user to go to a medical institution and use a complex detection instrument for the biochemical detection, improving the detection efficiency, simplifying the detection process, and significantly improving the user experience.

[0089] The above-described specific embodiments further illustrate the purpose, technical solutions and beneficial effects of the present application. It should be understood that the above-described specific embodiments are merely examples of the present application and are not intended to limit the protection scope of the present application. It is particularly pointed out that any modification, equivalent replacement, improvement, etc. made by those skilled in the art within the spirit and principles of the present application shall be included in the protection scope of the present application.

Claims

1. A biochemical marker detection method, characterized by, The method is executed by a user and realized by a biochemical index detection device, and the biochemical index detection device comprises a terminal with a capacitive touch screen, a detection film, a first wire, a first conductive electrode, a second wire and a second conductive electrode; the detection film is arranged on the capacitive touch screen of the terminal and used for dropping a sample to be detected; the first conductive electrode is connected with the detection film through the first wire; and the second conductive electrode is connected with the detection film through the second wire. The method comprises: starting a touch screen signal feedback module of the terminal; dropping the sample to be detected to the detection film on the capacitive touch screen of the terminal; contacting a detection trigger device until the terminal feeds back a value after processing the sample to be detected, and taking the value as a detection result; wherein the detection trigger device comprises the first conductive electrode and the second conductive electrode; the contacting detection trigger device until the terminal feeds back a value after processing the sample to be detected, and taking the value as a detection result, further comprises: separately arranging the first conductive electrode and the second conductive electrode and contacting one of the conductive electrodes to obtain a first detection result; completely attaching the first conductive electrode and the second conductive electrode and contacting the first conductive electrode and the second conductive electrode to obtain a second detection result, so that the terminal processes the first detection result and the second detection result to obtain a real detection result.

2. The biochemical indicator detection method as described in claim 1, characterized in that, The thickness of the detection film of the biochemical index detection device is less than 2 mm.

3. The biochemical indicator detection method as described in claim 2, characterized in that, The material of the detection film of the biochemical index detection device comprises a high polymer material and a glass material, wherein the high polymer material comprises one or more of polypropylene, polyethylene, polyvinyl chloride, polystyrene, polyethylene terephthalate and polymethyl methacrylate.

4. A biochemical marker detection method, characterized by, The method is executed by a user and realized by a biochemical index detection device, and the biochemical index detection device comprises a terminal with a capacitive touch screen, a detection film, a first wire, a first conductive electrode, a second wire and a second conductive electrode; the detection film is arranged on the capacitive touch screen of the terminal and used for dropping a sample to be detected; the first conductive electrode is connected with the detection film through the first wire; and the second conductive electrode is connected with the detection film through the second wire. The method comprises: in response to the user dropping the sample to be detected and contacting the detection trigger device, controlling the touch screen signal feedback module to detect an initial capacitance value in the capacitive touch screen; eliminating the initial capacitance value to obtain a total amount of effective data; obtaining a unit capacitance mean value according to the total amount of effective data and the capacitance value corresponding to the effective data; comparing with a preset reference value corresponding table to obtain a detection result of the sample to be detected; and in response to the user separately arranging the first conductive electrode and the second conductive electrode and contacting one of the conductive electrodes, recording a first detection result; in response to the user completely attaching the first conductive electrode and the second conductive electrode and contacting the first conductive electrode and the second conductive electrode, recording a second detection result. ​ According to the first detection result and the second detection result, a real detection result of ions corresponding to a detection item in the sample to be detected is obtained.

5. The biochemical indicator detection method as described in claim 4, characterized in that, Further comprising: In response to the detection item selected by the user, a preset reference value corresponding table corresponding to the detection item selected by the user is called; wherein the preset reference value corresponding table comprises a corresponding relationship between each concentration of ions corresponding to a detection item in the sample to be detected and a unit capacitance value.

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