Intelligent reaction sequence control system and method

Abstract

The present invention discloses an intelligent reaction sequence control system, including an inlet channel, a reaction chamber, at least two control units and at least two transport channels, wherein the control unit corresponds to the transport channel one by one; the control unit is arranged between the inlet channel and the transport channel, and different control units have different fluid transmembrane pressure thresholds; the transport channel is arranged between the corresponding control unit and the reaction chamber and is used to install different reactants, and the transport fluid is pressurized to pass through different control units in sequence and push the reactants in the corresponding transport channel into the reaction chamber for reaction, thereby realizing intelligent control of the reaction sequence. The control method of the reaction sequence control system based on the present invention has the characteristics of simple control, easy operation, and no need for complex procedures.

Description

Technical Field

[0001] The invention relates to an intelligent reaction sequence control system and method, belonging to the field of reaction control technology design. Background Art

[0002] Reaction sequence control technology is widely used in chemistry, chemical engineering, materials science, life science, medicine and other fields. It is a key technology for organic synthesis, targeted drug release, water treatment, pollutant degradation, etc. The reaction system usually involves multiple chemical reactions, which may occur simultaneously or successively. The order of the reactions is crucial to the products and yields. Reaction sequence control has been widely used in organisms. Organisms widely use enzymes, proteins, metabolites or DNA to control the order of reactions in various biological processes such as DNA replication, cell proliferation, metabolism, etc. In the fields of pharmaceuticals, chemical synthesis, material preparation, etc., the reaction sequence often determines the reaction route, product components, and yield. Reaction sequence control is of great significance in practical applications. By controlling the reaction sequence, the reaction route can be accurately controlled, thereby predicting the reaction results and products. However, in current industrial production, processes such as drug molecule synthesis, polymer preparation, food fermentation, material preparation, etc. or most reaction controls need to rely on complex electronic networks in electronics to control or cumbersome automated mechanical operations to complete, and the control system requires complex operating instructions or specialized microfluidic equipment to complete. Summary of the invention

[0003] The present invention provides an intelligent reaction sequence control system and method to solve the problems that the existing reaction sequence control technology needs to rely on complex electronic networks or operation instruction control, and the control equipment is not intelligent.

[0004] In order to achieve the above purpose, the technical solution of the present invention is:

[0005] An intelligent reaction sequence control system comprises an inlet channel, a reaction chamber, at least two control units and at least two transport channels, wherein the control units correspond to the transport channels one by one; the control unit is arranged between the inlet channel and the corresponding transport channel, and comprises an intelligent fluid and a porous membrane, wherein the intelligent fluid at least partially infiltrates the porous membrane and the two cooperate to control the transport fluid to enter the corresponding transport channel from the inlet channel; different control units have different fluid transmembrane pressure thresholds; the transport channel is arranged between the corresponding control unit and the reaction chamber and is used to accommodate different reactants, and pressure is applied to the transport fluid to make it pass through different control units in sequence and push the reactants in the corresponding transport channel into the reaction chamber.

[0006] Optionally, the at least two control units may be of different structures, or may be formed by the same porous membrane and different smart fluids, or may be implemented by the same porous membrane and the same smart fluid, by applying stimulation to at least one control unit to change the properties of the smart fluid so as to change the transmembrane pressure threshold of the fluid.

[0007] Optionally, the at least two control units consisting of the same porous membrane and the same smart fluid act on different areas of the same porous membrane through different stimuli to change the properties of the smart fluid in the corresponding areas so as to change the transmembrane pressure threshold of the fluid.

[0008] Optionally, the property change of the smart fluid includes a change in surface tension, concentration, hydrophilicity, hydrophobicity, viscosity, pH value, charge, solubility or component.

[0009] Optionally, the smart fluid includes a surfactant solution, an ionic liquid, a polymer solution, a hydrogel, an organogel, a worm micelle, a liquid crystal, an emulsion or a smart particle suspension; the stimulus includes one or more of acid, alkali, metal ions, oxidizing substances, reducing substances, light, a magnetic field, an electric field, and temperature.

[0010] Optionally, the porous membrane includes a nylon porous membrane, an aqueous mixed cellulose membrane, a polytetrafluoroethylene membrane, a polyvinylidene fluoride membrane, a porous glass membrane or a metal porous membrane.

[0011] Optionally, the pore size of the porous membrane is 1-100 μm.

[0012] Optionally, the transport fluid includes a gas flow including air, oxygen, nitrogen, argon, carbon dioxide or carbon monoxide.

[0013] Optionally, the smart fluid is a surfactant sodium selenoethercarboxylate (C 22 -Se-(COONa)2) aqueous solution with a concentration range of 0.1 to 1.0 mM, and the stimulant is at least one of H2O2, HCl, and H2O2-HCl.

[0014] A reaction control method based on the above intelligent reaction sequence control system comprises the following steps:

[0015] 1) Selecting a smart fluid and a porous membrane to form a control unit, applying a stimulus to at least one of the control units to change the properties of the smart fluid to generate different fluid transmembrane pressure thresholds;

[0016] 2) Assembling the intelligent reaction sequence control system and placing the reactants in corresponding transport channels according to a preset reaction sequence;

[0017] 3) A transport fluid is introduced from the inlet channel and the fluid pressure is gradually increased. The transport fluid passes through the corresponding control units in the order of the fluid transmembrane pressure threshold from small to large and pushes the corresponding reactants into the reaction chamber for reaction.

[0018] Optionally, the reactants include one or more of an inorganic acid, an organic acid, an organic base, an inorganic base, a metal salt, a metal complex, an acid-base indicator, a redox indicator, and a high molecular polymer.

[0019] Optionally, the reaction control method can be applied to information decryption.

[0020] The beneficial effects of the present invention are:

[0021] By setting control units with different transmembrane pressure thresholds for the fluid and connecting different transport channels, and gradually increasing the pressure of the inlet channel, the fluid can be allowed to pass through the control units with corresponding pressure thresholds from small to large in sequence and push the reactants in the corresponding transport channels to enter the reaction chamber for reaction in sequence, thereby realizing intelligent control of the reaction sequence. The control reaction sequence of the present invention does not require computer control, complex circuit control, or complex mechanical equipment, and has the characteristics of simple control, easy operation, and no need for complex procedures. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 This is a schematic diagram of the structure of the intelligent reaction sequence control system of Example 1;

[0023] Figure 2 The control principle diagram of the intelligent reaction sequence control system of Example 1;

[0024] Figure 3 It is a schematic diagram of the structure of the intelligent reaction sequence control system of Examples 2 and 3;

[0025] Figure 4 The surfactant C in Example 2 contains four different states. 22 -Se-(COONa)2, C 22 -SeOx-(COONa)2, C 22 -Se-(COOH)2, C 22 -SeOx-(COOH)2 control system pressure threshold as the surfactant concentration changes; where C 22 -Se-(COONa)2, C 22 -SeOx-(COONa)2, C 22 -Se-(COOH)2, C 22 -SeOx-(COOH)2 represents C 22-Se-(COONa)2 without adding stimulants and with adding stimulants H2O2, HCl, and H2O2-HCl respectively;

[0026] Figure 5 The four different states of surfactants (C 22 -Se-(COONa)2, C 22 -SeOx-(COONa)2, C 22 -Se-(COONa)2, C 22 -Se-(COONa)2) solution outlet flow rate and pressure;

[0027] Figure 6 This is a schematic diagram of the principle of intelligent control of the reaction sequence of Example 2;

[0028] Figure 7 This is a schematic diagram of the reaction sequence process of Example 2;

[0029] Figure 8 This is a schematic diagram of the information decryption process of Example 3. DETAILED DESCRIPTION

[0030] The present invention is further explained below in conjunction with the accompanying drawings and specific embodiments.

[0031] Example 1

[0032] Example 1 takes a two-channel intelligent reaction sequence control system as an example for explanation. Figure 1, which includes an inlet channel 1, a porous membrane support 2, a sealing material 3, a first control unit 4, a second control unit 4', a first reactant 5, a second reactant 5', a reaction chamber 6, a first transport channel 7, and a second transport channel 7', wherein the first control unit 4 is arranged between the inlet channel 1 and the first transport channel 7, the second control unit 4' is arranged between the inlet channel 1 and the second transport channel 7', and the first control unit 4 and the second control unit 4' are arranged in the porous membrane support 2 and sealed by the sealing material 3 to achieve an airtight connection between the inlet channel and the corresponding transport channel. The ends of the first transport channel 7 and the second transport channel 7' are respectively connected to the reaction chamber 6, the first reactant 5 is placed in the first transport channel 7, and the second reactant 5' is placed in the second transport channel 7', thereby forming two fluid branches from the inlet channel 1 to the reaction chamber 6. The first control unit 4 and the second control unit 4' respectively include a smart fluid and a porous membrane, wherein the smart fluid at least partially infiltrates the porous membrane and the two cooperate to form a gate switch for controlling the transport fluid to enter the corresponding transport channel from the inlet channel, and the first control unit 4 and the second control unit 4' have different fluid transmembrane pressure thresholds. The transport fluid is introduced into the inlet channel 1, and by increasing the pressure of the transport fluid, the transport fluid can pass through different control units in sequence and push the reactants in the corresponding transport channel into the reaction chamber. After entering the reaction chamber, the reactants will react in sequence.

[0033] Smart fluids include but are not limited to surfactant solutions, ionic liquids, polymer solutions, hydrogels, organogels, worm micelles, liquid crystals, emulsions, smart particle suspensions, and the like. Porous membranes include but are not limited to nylon porous membranes, aqueous mixed cellulose membranes, polytetrafluoroethylene membranes, polyvinylidene fluoride membranes, porous glass membranes, metal porous membranes, and the like, and the pore size range is micrometer level, for example, 1-100 μm. The smart fluid seals the mesh of the porous membrane in a closed state, and when the transport fluid pressure is applied to reach the critical pressure (i.e., the transmembrane pressure threshold) for passing, the gate switch is opened, and the transport fluid passes through the control unit. The transport fluid includes but is not limited to a gas flow such as air, oxygen, nitrogen, argon, carbon dioxide, carbon monoxide, and is limited to not reacting with the gated unit and the reactant. The reactant may be, for example, a fluid, or may be in other physical states, including but not limited to one or more of inorganic acids, organic acids, organic bases, inorganic bases, metal salts, metal complexes, acid-base indicators, redox indicators, and high molecular polymers.

[0034] The first control unit 4 and the second control unit 4' may have different structures, or may be formed by the same porous membrane and different smart fluids, or may be implemented by the same porous membrane and the same smart fluid. Figure 2, applying stimuli to the smart fluid 41 in different areas of the same porous membrane 42 to form different control units, and changing the properties of the smart fluid in the area where the stimuli are applied, such as surface tension, concentration, hydrophilicity, viscosity, pH value, charge, solubility, components, etc., through response, thereby affecting the transmembrane pressure threshold of the fluid passing through the control unit, making the transmembrane pressure thresholds of the two control units different, and in the process of increasing the pressure of the transported fluid, multiple control units are opened one after another to achieve sequential control. The stimuli include but are not limited to one or more of acids, alkalis, metal ions, oxidizing substances, reducing substances, light, magnetic fields, electric fields, temperature, etc. The effects of the stimuli and the smart fluid include but are not limited to van der Waals forces, hydrogen bonds, electrostatic forces, hydrophilicity and hydrophobicity, etc.

[0035] Example 2

[0036] refer to Figure 3 , select the surfactant sodium selenoethercarboxylate (C 22 -Se-(COONa)2) aqueous solution was used as the smart fluid and composited with a hydrophilic nylon filter membrane with a pore size of 30 μm to divide different membrane regions. By adding stimulants H2O2, HCl, and H2O2-HCl to different membrane regions, the surfactant structure was transformed into C 22 -SeOx-(COONa)2, C 22 -Se-(COOH)2, C 22 -SeOx-(COOH)2, so that the three regions form control units 4b, 4c and 4d respectively, and the partial region without adding stimuli forms control unit 4a. The transmembrane pressure thresholds of the fluids in control units 4a, 4b, 4c and 4d increase in sequence ( Figure 4 ), thereby obtaining control units with different pressure thresholds. The control units 4a, 4b, 4c and 4d correspond to the transport channels 7a, 7b, 7c and 7d one by one, and the transport channels 7a, 7b, 7c and 7d are respectively filled with NaOH droplets 5a, phenolphthalein droplets 5b, CuSO4 droplets 5c and HCl droplets 5d. Figure 5 As shown in the figure, by measuring the outlet flow rate in different states under pressurized conditions, it is found that the control units will be opened in sequence. The inlet channel 1 is loaded with air, and the pressure of the air in the air path in the initial state is lower than the pressure when the gas passes through all the control units. Figure 6 As shown, by increasing the air pressure, the gas passes through the control units 4a, 4b, 4c and 4d in sequence, thereby orderly pushing the reactants into the reaction chamber 6 in sequence (the order of reactants entering is: NaOH droplets, phenolphthalein droplets, CuSO4 droplets, HCl droplets) for reaction. The specific reaction process is as follows: Figure 7 shown.

[0037] Example 3

[0038] In practical applications, the present invention provides a system for controlling the reaction sequence based on response regulation to control the reaction sequence, such as information decryption. Figure 3 , select the surfactant sodium selenoethercarboxylate (C 22 -Se-(COONa)2) aqueous solution was used as a smart fluid and composited with a 5μm pore size aqueous mixed cellulose membrane to divide the membrane into different regions. By adding stimulants H2O2, HCl, and H2O2-HCl to different membrane regions, the surfactant structure was transformed into C 22 -SeOx-(COONa)2, C 22 -Se-(COOH)2, C 22 -SeOx-(COOH)2, so that these three areas form control units 4b, 4c and 4d respectively, and the partial area without adding stimulants forms control unit 4a, and the fluid transmembrane pressure thresholds of control units 4a, 4b, 4c and 4d are successively increased, thereby obtaining control units with different pressure thresholds. Control units 4a, 4b, 4c and 4d correspond to transport channels 7a, 7b, 7c and 7d one by one, and CuSO4 droplets 5a, iodine droplets 5b, tannic acid droplets 5c, and NaOH droplets 5d are respectively loaded into transport channels 7a, 7b, 7c and 7d. Nitrogen is loaded in the inlet channel 1, and the pressure of nitrogen in the gas path in the initial state is lower than the pressure when the gas passes through all control units. A specific test paper is placed in the reaction chamber 6, and KI solution, starch solution, FeCl3 solution, and phenolphthalein solution are coated on specific areas of the test paper, and then the test paper is blown dry. As Figure 8 As shown, by increasing the pressure of nitrogen, the gas is passed through the control units 4a, 4b, 4c and 4d in sequence, thereby pushing the reactants into the reaction chamber 6 in order (the order in which the reactants enter is: CuSO4 droplets, iodine droplets, tannic acid droplets, NaOH droplets), an orderly color reaction occurs on the test paper, and the decryption information is obtained based on the color information.

[0039] The above embodiments are only used to further illustrate an intelligent reaction sequence control system and method of the present invention, but the present invention is not limited to the embodiments. Any simple modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention fall within the protection scope of the technical solution of the present invention.

Claims

1. An intelligent reaction sequence control system, characterized in that: It includes an inlet channel, a reaction chamber, at least two control units and at least two transport channels, and the control units correspond to the transport channels one by one; The control unit is arranged between the inlet channel and the transport channel, and includes a smart fluid and a porous membrane, wherein the smart fluid at least partially infiltrates the porous membrane and the two cooperate to control the transport fluid to enter the corresponding transport channel from the inlet channel; the smart fluid includes a surfactant solution, an ionic liquid, a polymer solution, a hydrogel, an organic gel, a worm micelle, a liquid crystal, an emulsion or a smart particle suspension; Different control units have different fluid transmembrane pressure thresholds; the transport channel is arranged between the corresponding control unit and the reaction chamber and is used to accommodate different reactants, and the transport fluid is made to pass through different control units in turn by increasing the pressure of the transport fluid and push the reactants in the corresponding transport channel into the reaction chamber; the at least two control units adopt different structures, the same porous membrane and different smart fluids, or the same porous membrane and the same smart fluid composition, and the properties of the smart fluid are changed by applying stimulation to at least one control unit to change the fluid transmembrane pressure threshold, and the property changes of the smart fluid include changes in surface tension, concentration, hydrophilicity, viscosity, pH value, charge, solubility or components; the stimulation includes one or more of acid, alkali, metal ions, oxidizing substances, reducing substances, light, magnetic field, electric field, and temperature.

2. The intelligent reaction sequence control system according to claim 1 is characterized in that: The porous membrane includes a nylon porous membrane, an aqueous mixed cellulose membrane, a polytetrafluoroethylene membrane, a polyvinylidene fluoride membrane, a porous glass membrane or a metal porous membrane.

3. The intelligent reaction sequence control system according to claim 2 is characterized in that: The pore size of the porous membrane is 1-100 μm.

4. The intelligent reaction sequence control system according to claim 1 is characterized in that: The transport fluid includes a gas stream of air, oxygen, nitrogen, argon, carbon dioxide or carbon monoxide.

5. A reaction control method based on the intelligent reaction sequence control system according to any one of claims 1 to 4, characterized in that: The following steps are involved: 1) Selecting a smart fluid and a porous membrane to form a control unit, applying a stimulus to at least one of the control units to change the properties of the smart fluid to generate different transmembrane pressure thresholds of the fluid; 2) assembling the intelligent reaction sequence control system to place the reactants in corresponding transport channels according to a specific reaction sequence; 3) A transport fluid is introduced from the inlet channel and the pressure of the transport fluid is gradually increased. The transport fluid passes through the corresponding control units in the order of the fluid transmembrane pressure threshold from small to large and pushes the corresponding reactants into the reaction chamber for reaction.

6. The reaction control method according to claim 5, characterized in that: The reactants include one or more of inorganic acids, organic acids, organic bases, inorganic bases, metal salts, metal complexes, acid-base indicators, redox indicators, and high molecular polymers.

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