Automatic cap opening and sample loading device suitable for single molecule POCT device and single molecule POCT device comprising the same

Abstract

The application relates to an automatic cover opening and sample adding device suitable for a single molecule POCT device and a single molecule POCT device comprising the same, the automatic cover opening and sample adding device comprising a cover taking assembly, a sample adding assembly and a reagent adding assembly. The application can realize the cover opening and sample adding actions in a smaller space by integrating the three assemblies on the same mounting substrate, so that the compactness of the device is realized. The automatic cover opening and sample adding device is specially designed for the single molecule POCT device, and can fully meet the requirements of the portable and rapid diagnosis of the POCT device.

Description

TECHNICAL FIELD

[0001] The present application relates to a medical device, in particular to an automatic cap opening and sample adding device suitable for a single molecule POCT device and a single molecule POCT device comprising the same. BACKGROUND

[0002] Point of care testing (POCT), also known as rapid on-site diagnosis, bedside diagnosis, has the characteristics of convenient use and wide application range with the development of immunological technology and molecular biological technology, and is constantly attracting people's attention and attention in the new field of laboratory medicine. In recent years, in order to meet the needs of hypersensitive detection, single molecule immunodetection methods have been developed. However, there is no POCT device for single molecule immunodetection.

[0003] In the current immunological analyzer, most of the samples are loaded in test tubes, and the cap of the test tube needs to be opened in priority when the sample needle is sampling. The automatic cap opening device and sample adding device of the current commercial immunological analyzer (see patent documents 1-3) are mostly separated and independently arranged in different areas, and work under the driving of independent motion mechanisms to ensure the accuracy of the cap opening process, sampling process and reagent adding process. However, this working mode requires a large space, resulting in an inevitable increase in the size of the device, which cannot be applied to POCT devices.

[0004] Prior art documents

[0005] Patent document 1: CN208795750U;

[0006] Patent document 2: CN104444983A;

[0007] Patent document 3: CN111856047A. SUMMARY

[0008] In view of the above problems, the purpose of the present application is to provide an automatic cap opening and sample adding device suitable for a single molecule POCT device, which can effectively reduce the size of the module, has a simple and compact structure, and a single molecule POCT device comprising the same.

[0009] The present application comprises the following technical solutions.

[0010] In a first aspect, the present application relates to an automatic cap opening and sample adding device suitable for a single molecule POCT device, comprising a cap taking assembly, a sample adding assembly and a reagent adding assembly mounted on the same mounting substrate,

[0011] The cap taking assembly and the sample adding assembly are mounted on the same side of the mounting substrate and share a Y-axis motion mechanism, and move together in the Y-axis direction, i.e. the horizontal direction, and the reagent adding assembly is mounted on the other side of the mounting substrate,

[0012] The installation base plate is cuboid, and one Y-axis movement mechanism is installed on each of the two sides of the installation base plate,

[0013] The sample adding assembly and the reagent adding assembly each comprise a sample needle, a Z-axis movement mechanism, an anti-collision mechanism and a liquid level detection mechanism.

[0014] In an embodiment, the two Y-axis movement mechanisms each comprise a stepping motor, a linear guide rail and a synchronous belt, and the stepping motors of the two Y-axis movement mechanisms are installed on the same side as the reagent adding assembly and are arranged on the installation base plate in an up-down manner.

[0015] In an embodiment, the anti-collision mechanism comprises an anti-collision light coupling, a spring, an anti-collision baffle and an anti-collision rod,

[0016] The spring is sleeved on the anti-collision rod,

[0017] The anti-collision baffle is connected with the anti-collision rod and has a front end in the anti-collision light coupling, and when the sample needle collides, the front end of the anti-collision baffle protrudes from the anti-collision light coupling,

[0018] The anti-collision light coupling is arranged on the liquid level detection mechanism.

[0019] In an embodiment, the Z-axis movement mechanism comprises a stepping motor, a synchronous belt, a driving wheel, a driven wheel, a single linear guide rail and a Z-axis zero position light coupling.

[0020] In an embodiment, the cap taking assembly comprises a cap taking module, a fixing module and an L-shaped mounting plate, the cap taking module is connected with the vertical plate of the L-shaped mounting plate, and the fixing module is connected with the horizontal plate of the L-shaped mounting plate,

[0021] The cap taking module comprises two cap taking clamps, a cap taking motor, a Z-axis lead screw motor and a sliding rail connecting piece, the cap taking clamps are located below the cap taking motor, and the cap taking motor is connected with the Z-axis lead screw motor through the sliding rail connecting piece,

[0022] The fixing module comprises two fixing clamps, an X-axis lead screw motor, an X-axis linear guide rail and a fixing clamp opening and closing motor, the fixing clamps are directly connected with the fixing clamp opening and closing motor, the fixing clamp opening and closing motor is connected with the X-axis lead screw motor through a connecting piece, and the upper portion of the X-axis lead screw motor is provided with the X-axis linear guide rail.

[0023] In an embodiment, the cap taking motor is used for opening and closing and rotating the cap taking clamps, the Z-axis lead screw motor is used for moving the cap taking module in the Z-axis direction, i.e. the vertical direction, the X-axis lead screw motor is used for moving the fixing clamps in the X-axis direction, i.e. the horizontal direction, and the fixing clamp opening and closing motor is used for opening and closing the fixing clamps.

[0024] In one embodiment, a hole is formed in the center of the bottom of the horizontal plate of the L-shaped mounting plate for the screw rod of the Z-axis screw rod motor to pass through.

[0025] In one embodiment, the inner side of the two cap-taking clamping hands is provided with an arc-shaped groove matched with the test tube cap, and the inner side of the two fixing clamping hands is smooth and not provided with an arc-shaped groove.

[0026] In one embodiment, the X-axis screw rod motor drives the fixing clamping hand opening and closing motor to move back and forth in the X-axis direction through the X-axis linear guide rail and the connecting piece, so that the fixing clamping hand moves back and forth in the X-axis direction.

[0027] In the automatic cap-opening and sample adding device for single-molecule POCT equipment described above, for the first time, the cap-taking assembly, the sample adding assembly and the reagent adding assembly are arranged on the same mounting base, in addition, the cap-taking assembly and the sample adding assembly use the same Y-axis movement mechanism, and the components of each assembly are arranged at appropriate positions on both sides of the mounting base, so that the cap-opening and sample adding actions can be realized in a limited space, the device is more compact while ensuring basic functions, and can be properly used for single-molecule POCT equipment.

[0028] On the other hand, the present application relates to a single-molecule POCT equipment comprising the automatic cap-opening and sample adding device of any one of the above.

[0029] Compared with the prior art, the present application can obtain the following excellent effects:

[0030] (1) Through the specific structure of the automatic cap-opening and sample adding device of the present application, in particular, the cap-taking assembly, the sample adding assembly and the reagent adding assembly are arranged on both sides of the same mounting base, the cap-taking assembly and the sample adding assembly use the same Y-axis movement mechanism, and the like, so that the overall volume of the module can be controlled in the smallest range while ensuring basic functions, the device is more compact, and is well suitable for single-molecule POCT equipment;

[0031] (2) The number of required driving devices is less, and the cost is reduced;

[0032] (3) Through the automatic cap-opening and sample adding device of the present application, after the sample is taken from the test tube, the test tube cap can be returned to the original position without waste collection and treatment, which greatly saves space and time, and also reduces the cost;

[0033] (4) In the preferred scheme, the volume of each assembly itself is also relatively compact, further realizing the reduction of the volume of the device. BRIEF DESCRIPTION OF DRAWINGS

[0034] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings needed to be used in the embodiments will be briefly introduced as follows. It should be understood that the following drawings only show some of the embodiments of the present application, and therefore should not be regarded as a limitation on the scope, and for those of ordinary skill in the art, other related drawings can also be obtained without creative labor on the basis of these drawings.

[0035] Figure 1 A perspective view of the automatic cap opening and sample adding device of the present application is shown from the side of the cap taking assembly.

[0036] Figure 2 A perspective view of the automatic cap opening and sample adding device of the present application is shown from the side of the reagent sample adding assembly.

[0037] Figure 3 A top view of the automatic cap opening and sample adding device of the present application.

[0038] Figure 4 A perspective view of the cap taking assembly of the present application.

[0039] Figure 5 A front view of the cap taking assembly of the present application.

[0040] Figure 6 A perspective view of the sample sample adding assembly of the present application.

[0041] Figure 7 A perspective view of the reagent sample adding assembly of the present application.

[0042] Reference signs: 1-cap taking assembly; 2-sample sample adding assembly; 3-reagent sample adding assembly; 4-mounting base plate;

[0043] 51-stepper motor; 52-linear guide rail; 53-synchronous belt; 54-stepper motor; 55-linear guide rail; 56-synchronous belt;

[0044] 11-cap taking module; 12-fixing module; 13-L-shaped mounting plate; 111, 112-cap taking clamping hand; 113-cap taking motor; 114-Z-axis screw motor; 1141-screw rod; 115-sliding rail connecting piece; 121, 122-fixing clamping hand; 123-X-axis screw motor; 124-X-axis linear guide rail; 125-fixing clamping hand opening and closing motor; 126-connecting piece; 131-vertical plate of L-shaped mounting plate 13, 132-horizontal plate of L-shaped mounting plate 13;

[0045] 21 - sample needle; 22 - Z-axis motion mechanism; 23 - anti-collision mechanism; 24 - liquid level detection mechanism; 25 - L-shaped mounting plate; 221 - stepper motor; 222 - synchronous belt; 223 - driving wheel; 224 - driven wheel; 225 - single linear guide rail; 231 - anti-collision photoelectric coupler; 232 - spring; 233 - anti-collision baffle; 234 - anti-collision rod;

[0046] 31 - reagent needle; 32 - Z-axis motion mechanism; 33 - anti-collision mechanism; 34 - liquid level detection mechanism; 321 - stepper motor; 322 - Z-axis zero position photoelectric coupler; 331 - anti-collision photoelectric coupler; 332 - spring; 333 - anti-collision baffle; 334 - anti-collision rod. DETAILED DESCRIPTION

[0047] In addition, the terms "horizontal", "vertical", "overhanging", and the like do not mean that the components must be absolutely horizontal or overhanging, but can be slightly inclined. For example, "horizontal" only means that it is more horizontal than "vertical", and does not mean that the structure must be completely horizontal, but can be slightly inclined.

[0048] In the description of the present application, it should be noted that the terms "in", "out", "left", "right", "up", "down", and the like indicate the orientation or positional relationship shown in the drawings, or the orientation or positional relationship commonly used when the product of the present application is used, and are only for the convenience of describing the present application and simplifying the description, and therefore cannot be understood as indicating or implying that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application.

[0049] In the description of the present application, unless otherwise explicitly specified and limited, the terms "arranged", "mounted", "connected", "linked" should be understood broadly, for example, can be fixedly connected, or can be detachably connected, or integrally connected; can be mechanically connected, or can be electrically connected; can be directly connected, or can be indirectly connected through an intermediate medium, or can be internal communication of two elements.

[0050] The technical solutions of the present application will be described below in conjunction with the drawings.

[0051] Figure 1 A perspective view of the automatic cap opening and sample adding device of the present application is observed from one side of the cap taking assembly. The automatic cap opening and sample adding device of the present application comprises a cap taking assembly 1, a sample adding assembly 2 and a reagent adding assembly 3 mounted on the same mounting base plate 4. Figure 1In the embodiment, the cap taking assembly 1 and the sample adding assembly 2 are installed on the same side of the mounting base 4 and share a Y-axis movement mechanism, and move together in the Y-axis direction, i.e. the horizontal direction, and the cap taking assembly 1 and the sample adding assembly 2 are arranged side by side along the Y-axis direction. On the other hand, the reagent adding assembly 3 is installed on the other side (the back side) of the mounting base 4. Figure 1 The mounting base 4 is in the shape of a cuboid, and one Y-axis movement mechanism is installed on each of the two sides of the mounting base 4. Each Y-axis movement mechanism comprises a stepping motor, a linear guide rail and a synchronous belt, and can further comprise a zero position photoelectric coupler at one end of the synchronous belt, so as to position the components well. The cap taking assembly 1 and the sample adding assembly 2 can be connected to the Y-axis movement mechanism by various connection methods known in the art, without particular limitation. Figure 1 In the embodiment, the sample adding assembly 2 is fixed to the Y-axis movement mechanism by a sliding block, and the cap taking assembly is connected to the sliding block by a connecting piece.

[0052] As shown in FIG. 1, the cap taking assembly 1 and the sample adding assembly 2 are arranged side by side along the Y-axis direction. Figure 1 As shown in FIG. 1, the cap taking assembly 1 and the sample adding assembly 2 are arranged side by side along the Y-axis direction.

[0053] Figure 1 In the embodiment, the stepping motor 51, the linear guide rail 52 and the synchronous belt 53 are arranged in the middle lower part of the mounting base 1, but are not limited thereto, and can also be arranged in the middle upper part of the mounting base 1. In order to shorten the moving distance of the cap taking assembly 1 and the sample adding assembly 2 in the Z-axis direction as much as possible and improve the detection rate, the stepping motor 51, the linear guide rail 52 and the synchronous belt 53 are preferably arranged in the middle lower part of the mounting base 1.

[0054] The cap taking assembly 1 and the sample adding assembly 2 share the same Y-axis movement mechanism comprising the stepping motor 51, the linear guide rail 52 and the synchronous belt 53, thereby reducing the number of driving mechanisms, making the device more compact and reducing the cost.

[0055] Figure 2 A perspective view of the automatic cap opening and adding device of the present application from the side of the reagent adding assembly. As shown in FIG. 1, Figure 2As shown, the reagent dispensing assembly 3 is positioned on the mounting base plate 1 on a side different from the cap dispensing assembly. At one end along the Y-axis, two stepper motors 51 and 54 are provided. Stepper motor 51 serves as the drive source for the Y-axis motion mechanism shared by the cap dispensing assembly 1 and the sample dispensing assembly 2, while stepper motor 54 serves as the drive source for the Y-axis motion mechanism corresponding to the reagent dispensing assembly 3. Stepper motor 51 is positioned below stepper motor 54. The Y-axis motion mechanism driving the reagent dispensing assembly 3 in the Y-axis direction also includes stepper motor 54, linear guide rail 55, and synchronous belt 56. Compared to the shared Y-axis motion mechanism of the cap dispensing assembly 1 and the sample dispensing assembly 2, the Y-axis motion mechanism driving the reagent dispensing assembly 3 in the Y-axis direction is located in the upper middle part. Through this arrangement, the cap dispensing assembly 1, sample dispensing assembly 2, and reagent dispensing assembly 3, along with their drive mechanisms, can be cleverly arranged on a single mounting base plate. While achieving their respective basic functions, this significantly reduces the size of the device, making the equipment more compact. In addition, a zero-position optocoupler can be provided at the other end of the Y-axis (the side opposite to the end where the stepper motor is located) for better positioning.

[0056] Figure 3 This is a top view of the automatic cap-opening and sample-dispensing device of this application. Figure 3 As shown, the cap-removing assembly 1 and the sample dispensing assembly 2 are located on the left side of the mounting base 1, and the reagent dispensing assembly 3 is located on the right side of the mounting base 1. The stepper motors 51 and 54 of the two Y-axis motion mechanisms are both located at one end of the right side of the mounting base 1. The cap-removing assembly 1 and the sample dispensing assembly 2 can be connected together by the Z-axis mounting base and connecting block of the cap-removing assembly 1, and move together in the Y-axis direction, but are not limited thereto.

[0057] The above describes the arrangement of the cap-removing assembly 1, sample dispensing assembly 2, and reagent dispensing assembly 3, as well as their driving mechanisms, on the mounting substrate. The specific structure of each assembly is described below.

[0058] Figure 4 This is a perspective view of the cap removal assembly 1 of this application, including a cap removal module 11, a fixing module 12, and an L-shaped mounting plate 13. The cap removal module 11 includes two cap removal grippers 111 and 112 (shown in...). Figure 5 The fixing module 2 includes two fixing grippers 121 and 122, an X-axis lead screw motor 123, and an X-axis linear guide rail 124 (shown in the middle), a cover-removing motor 113, a Z-axis lead screw motor 114, and a slide rail connector 115. Figure 5 The middle) and the fixed clamp opening and closing motor 125. The cover removal module 11 is connected to the vertical plate 131 of the L-shaped mounting plate 13, and the fixing module 12 is connected to the horizontal plate 132 of the L-shaped mounting plate 13.

[0059] The cover taking clamps 111 and 112 are located below the cover taking motor 113, and the cover taking motor 113 is connected with the Z-axis screw motor 114 through the slide rail connecting piece 115. The inner sides of the two cover taking clamps 111 and 112 are provided with arc-shaped grooves matched with the test tube covers, for firmly clamping the test tube covers and rotating the test tube covers. The cover taking motor 113 is used for opening and closing the cover taking clamps and rotating the cover taking clamps. Here, a pneumatic device is not used, so that the situation that the test tube clamp is broken or the clamping force is not enough due to unstable air pressure can be avoided. The specific structure of the slide rail connecting piece 115 can be various, as long as the cover taking motor and the Z-axis screw motor 114 can be slidably connected. In the embodiment, it includes a hollow block through which the screw rod of the Z-axis screw motor 114 passes and a connecting block directly connected with the cover taking motor 113. The hollow block and the connecting block are connected by screws. The shape of the cover taking motor can be various, and in the embodiment, it is cylindrical, which can make the structure more compact.

[0060] The cover taking module 11 is connected with the vertical plate 131 of the L-shaped mounting plate 13, specifically, at the upper part of the cover taking motor of the cover taking module, the cover taking motor is slidably connected with the vertical plate 131 of the L-shaped mounting plate 13 through a slide rail. The L-shaped mounting plate 13 is provided with a slide rail for the cover taking motor to slide, and the top end of the cover taking motor 113 is substantially flush with the top end of the L-shaped mounting plate 13, so that the structure is more compact.

[0061] The uppermost end of the screw rod 1141 of the Z-axis screw motor 114 can be slightly lower than the top end of the cover taking motor 113, in order to balance the maximum moving distance in the Z-axis direction and the cost. The screw rod 1141 of the Z-axis screw motor 114 passes through the central hole of the horizontal plate 132 of the L-shaped mounting plate 13, and the motor part of the Z-axis screw motor 114 is arranged below the horizontal plate 132 of the L-shaped mounting plate 13 and adjacent to the X-axis screw motor 123 of the fixing module 12. By arranging the Z-axis screw motor 114 to make the cover taking clamps move up and down, the height of the cover taking clamps can be adjusted, the space utilization rate is high, and it is suitable for sample test tubes of different heights, meets the situation that high and low test tubes are used at the same time in the detection and analysis equipment in the prior art, greatly increases the application range of the entire POCT equipment, and effectively solves the sample and test tube matching problem in the prior art.

[0062] In order to better illustrate the structure of the fixing module 12, the following uses the accompanying drawings to Figure 5 illustrate. Figure 5It is a front view of the tube opening device. The fixed module 12 mainly comprises two fixed clamping hands 121 and 122, an X-axis screw motor 123, an X-axis linear guide rail 124 and a fixed clamping hand opening and closing motor 125. The fixed module 12 is arranged below the horizontal plate of the L-shaped mounting plate through a connecting piece, and is sequentially provided with the X-axis linear guide rail 124, the X-axis screw motor 123, the fixed clamping hand opening and closing motor 125 and the two fixed clamping hands 121 and 122 from top to bottom, wherein the two fixed clamping hands 121 and 122 are located directly below the motor part of the X-axis screw motor 123.

[0063] The X-axis linear guide rail 124 is connected with the horizontal plate of the L-shaped mounting plate through a connecting piece and is arranged above the X-axis screw motor 123. The X-axis screw motor 123 drives the fixed clamping hand opening and closing motor 125 to move horizontally in the X-axis direction through the X-axis linear guide rail and another connecting piece 126 (connecting piece connecting the X-axis screw motor 123 and the fixed clamping hand opening and closing motor 125), thereby driving the fixed clamping hands 121 and 122 connected with the fixed clamping hand opening and closing motor 125 to move horizontally in the X-axis direction.

[0064] The fixed clamping hand opening and closing motor 125 is used for opening and closing the fixed clamping hands 121 and 122 and is generally columnar. The fixed clamping hands 121 and 122 are completely identical and are ladder-shaped in cross section, and the inner sides of the two fixed clamping hands are smooth and are not provided with arc-shaped grooves.

[0065] Next, the specific process of taking the cover is illustrated.

[0066] When adding samples, the sample rack is transferred from the sample bin to the sample scheduling trolley assembly, and after the sample tube is scanned, the sample test tube is stopped at the designated sampling position. The fixed clamping hand opening and closing motor 125 of the fixed module 12 separates the fixed clamping hands 121 and 122, and the X-axis screw motor 123 drives the fixed clamping hands 121 and 122 to move to the test tube position through the X-axis linear guide rail and the connecting piece, and the two clamping hands are closed to complete the test tube fixing action. Then the cover taking clamping hands 111 and 112 are opened under the action of the cover taking motor 113, and through the coordinated movement between the Z-axis screw motor, the slide rail connecting piece and other connecting pieces, the cover taking clamping hands 111 and 112 are moved to the cover part of the sample test tube, and the two cover taking clamping hands are closed. After clamping the test tube cover, the cover taking motor 113 rotates the two cover taking clamping hands, and under the action of the Z-axis screw motor, the cover taking motor 113 and the two cover taking clamping hands rise together to take off the test tube cover, and the cover taking action is completed. After a sample test tube is sampled, the cover taking clamping hands can continue to put the test tube cover back to the test tube, without throwing the cover and waste collection and treatment, thereby saving space and reducing the possibility of biological pollution.

[0067] Figure 6Figure 1 is a perspective view of a sample loading assembly 2 of the present application, which includes a sample needle 21, a Z-axis motion mechanism 22, a collision prevention mechanism 23, and a liquid level detection mechanism 24. The Z-axis motion mechanism 22 includes a stepper motor 221, a synchronous belt 222, a driving wheel 223, a driven wheel 224, a single linear guide rail 225, and a Z-axis zero position photoelectric coupler (not shown, which can be located at the uppermost end).

[0068] The collision prevention mechanism 23 includes a collision prevention photoelectric coupler 231, a spring 232, a collision prevention stopper 233, and a collision prevention rod 234. The spring 232 is sleeved on the collision prevention rod 234, and the collision prevention stopper 233 is connected to the collision prevention rod 234 and has a front end located in the collision prevention photoelectric coupler 231. When the sample needle 21 collides, the front end of the collision prevention stopper 233 protrudes from the collision prevention photoelectric coupler 231, so that the collision prevention photoelectric coupler 231 senses a signal and alarms. The collision prevention photoelectric coupler 231 can be arranged on the circuit board of the liquid level detection mechanism 24 to make the structure compact.

[0069] The liquid level detection mechanism 24 and the collision prevention mechanism 23 are arranged on the same L-shaped mounting plate 25, and the liquid level detection mechanism 24 is arranged above the collision prevention mechanism 23. The L-shaped mounting plate 25 is connected to the single linear guide rail 225 of the Z-axis motion mechanism 22 through a sliding block. The sample needle 21 is arranged below the L-shaped mounting plate to suck and add a sample.

[0070] Figure 7 Figure 2 is a perspective view of a reagent loading assembly 3 of the present application, which has substantially the same components as the sample loading assembly 2 and includes a reagent needle 31, a Z-axis motion mechanism 32, a collision prevention mechanism 33, and a liquid level detection mechanism 34. The Z-axis motion mechanism 32 also includes a stepper motor 321, a synchronous belt (on the back, not shown), a driving wheel (on the back, not shown), a driven wheel (on the back, not shown), a single linear guide rail (on the back, not shown), and a Z-axis zero position photoelectric coupler 322.

[0071] The collision prevention mechanism 33 includes a collision prevention photoelectric coupler 331, a spring 332, a collision prevention stopper 333, and a collision prevention rod 334. The spring 332 is sleeved on the collision prevention rod 334, and the collision prevention stopper 333 is connected to the collision prevention rod 334 and has a front end located in the collision prevention photoelectric coupler 331. When the reagent needle 31 collides, the front end of the collision prevention stopper 333 protrudes from the collision prevention photoelectric coupler 331, so that the collision prevention photoelectric coupler 331 senses a signal and alarms. The collision prevention photoelectric coupler 331 can be arranged on the circuit board of the liquid level detection mechanism 34 to make the structure compact.

[0072] The following is a brief description of the overall operation process of the automatic cover opening and sample loading device of the present application.

[0073] When the test tube reaches the designated sample adding position, the two fixed clamping hands 121 and 122 of the cover opening assembly are opened, the two fixed clamping hands are sent to the test tube by the X-shaft screw motor 123, the fixed clamping hands are closed to clamp the test tube. Then, the two cover clamping hands 111 and 112 of the cover opening assembly are opened, the Z-shaft screw motor 114 is lowered to the position of the test tube cover, the cover clamping hands are clamped and rotated at the same time, the Z-shaft screw motor drives the cover clamping hands to rise, thereby opening the test tube cover. Next, under the drive of the Y-shaft movement mechanism, the sample needle 21 of the sample adding assembly 2 moves to the test tube, under the drive of the Z-shaft movement mechanism, the sample needle 21 is lowered to sample. After sampling is completed, the sample is added to the empty reaction cup in the incubation chamber, and the addition of reagent is waited to mix the reaction. On the other hand, the reagent adding assembly 3 moves to the reagent chamber sampling port, under the drive of the Z-shaft movement mechanism, the reagent needle 31 is lowered to sample, then under the drive of the Y-shaft movement mechanism, it moves to the reagent adding position of the incubation chamber, the reagent is added to the reaction cup with the sample, and the reagent adding is completed.

[0074] The above only is the preferred embodiment of the present application, and is not used to limit the present application, for the person skilled in the art, the present application can have various changes and changes. Any modification, equivalent replacement, improvement, etc. within the spirit and principle of the present application should be included in the protection scope of the present application.

Claims

1. An automated capping and sample dispensing device suitable for single-molecule POCT equipment, comprising a cap dispensing assembly, a sample dispensing assembly, and a reagent dispensing assembly mounted on the same mounting substrate. The cap removal assembly and the sample dispensing assembly are mounted on the same side of the mounting base and share a Y-axis motion mechanism, moving together in the Y-axis direction, i.e., the horizontal direction. The reagent dispensing assembly is mounted on the other side of the mounting base. The mounting base plate has a Y-axis motion mechanism mounted on each of its two sides. Both the sample dispensing assembly and the reagent dispensing assembly include a sample needle, a Z-axis motion mechanism, an anti-collision mechanism, and a liquid level detection mechanism. Both Y-axis motion mechanisms include stepper motors, linear guides, and synchronous belts. The stepper motors in both Y-axis motion mechanisms are mounted on the same side as the reagent dispensing assembly, and are arranged vertically on the mounting base. The Z-axis motion mechanism includes a stepper motor, a synchronous belt, a driving pulley, a driven pulley, a single linear guide rail, and a Z-axis zero-position optocoupler; The cap removal assembly includes a cap removal module, a fixing module, and an L-shaped mounting plate. The cap removal module is connected to the vertical plate of the L-shaped mounting plate, and the fixing module is connected to the horizontal plate of the L-shaped mounting plate. The cap removal module includes two cap removal grippers, a cap removal motor, a Z-axis lead screw motor, and a slide rail connector. The cap removal grippers are located below the cap removal motor, and the cap removal motor is connected to the Z-axis lead screw motor via the slide rail connector. The fixing module includes two fixed grippers, an X-axis lead screw motor, an X-axis linear guide rail, and a fixed gripper opening and closing motor. The fixed grippers are directly connected to the fixed gripper opening and closing motor, and the fixed gripper opening and closing motor is connected to the X-axis lead screw motor through a connector. An X-axis linear guide rail is provided on the upper part of the X-axis lead screw motor. The cap-removing motor is used to open, close, and rotate the cap-removing gripper; the Z-axis lead screw motor is used to move the cap-removing module in the Z-axis direction, i.e., the vertical direction; the X-axis lead screw motor is used to move the fixed gripper in the X-axis direction, i.e., the horizontal direction; and the fixed gripper opening and closing motor is used to open and close the fixed gripper.

2. The automatic cap-opening and sample-dispensing device as described in claim 1, wherein, The anti-collision mechanism includes an anti-collision optical coupler, a spring, an anti-collision baffle, and an anti-collision rod. The spring is fitted onto the anti-collision bar. The anti-collision baffle is connected to the anti-collision rod and its front end is located in the anti-collision optocoupler. When the sample needle collides, the front end of the anti-collision baffle protrudes from the anti-collision optocoupler. The anti-collision optical coupler is mounted on the liquid level detection mechanism.

3. The automatic cap-opening and sample-dispensing device as described in claim 1, wherein, The bottom center of the horizontal plate of the L-shaped mounting plate has a hole through which the lead screw of the Z-axis lead screw motor passes.

4. The automatic cap-opening and sample-dispensing device as described in claim 1, wherein, The inner sides of the two cap-removing grippers are provided with arc-shaped grooves that match the test tube caps, while the inner sides of the two fixing grippers are smooth and do not have arc-shaped grooves.

5. The automatic cap-opening and sample-dispensing device as described in claim 1, wherein, The X-axis lead screw motor drives the fixed gripper opening and closing motor to move back and forth in the X-axis direction through the X-axis linear guide and connecting parts, thereby causing the fixed gripper to move back and forth in the X-axis direction.

6. A single-molecule POCT device comprising the automatic capping and sample dispensing device according to any one of claims 1 to 5.

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