Liquid line heating device and washing module

By designing a liquid line tube heating device, using the heating chamber and heating assembly to heat the washing liquid and substrate in advance, the problem of difficulty in effectively controlling the liquid temperature in the reaction cup in the prior art is solved, the detection accuracy is improved and the liquid heat dissipation time is reduced.

CN115488117BActive Publication Date: 2025-04-15科来思生物科技(重庆)有限公司
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Patent Information

Application Number
CN202211322610.4
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-10-27
Publication Date
2025-04-15
Estimated Expiration
2042-10-27

AI Technical Summary

Technical Problem

The washing module of existing chemiluminescence immunoassays is difficult to effectively control the temperature of the liquid in the reaction cup, resulting in low detection accuracy.

Method used

A liquid pipe heating device is designed, including an installation tray with a heating chamber inside, a pipe winding block is used to wrap the liquid pipeline, and a heating assembly is used to heat the heating chamber so as to heat the washing liquid and substrate to a desired temperature in advance.

Benefits of technology

By heating the washing liquid and substrate in advance, ensuring that the liquid temperature in the reaction cup is controlled within the ideal range, improving the detection accuracy of the chemiluminescent immunoassay device and reducing the heat dissipation time of the liquid in the air.

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Abstract

The present invention discloses a liquid pipe heating device and a washing module, comprising a mounting plate with a heating chamber inside, a pipeline winding block installed in the heating chamber, the pipeline winding block is used to wind the liquid pipeline, an inlet and an outlet are provided on the mounting plate, the inlet and the outlet are both connected to the heating chamber, and are respectively used to introduce and lead out the liquid pipeline wound on the pipeline winding block; a heating component is provided on the mounting plate, which is used to heat up the heating chamber. The washing module comprises a base, a circular turntable is rotatably installed in the base, the mounting plate is installed above the circular turntable, the outlet is arranged at the outer end of the mounting plate, and an injection needle is installed in the outlet. The beneficial effects of the present invention are: the washing liquid and the substrate can be heated to the required temperature in advance, ensuring that the liquid temperature in the reaction cup is controlled within a more precise range, which helps to improve the final detection accuracy of the chemiluminescence immunoassay analyzer.
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Description

Technical Field

[0001] The invention relates to a chemiluminescent immunoassay analyzer, and in particular to a liquid line tube heating device and a washing module. Background Art

[0002] The chemiluminescence immunoassay analyzer is a medical testing instrument that performs immunoassay by testing serum. By combining the highly sensitive chemiluminescence assay technology with the highly specific immune response, it can be used for the detection and analysis of various antigens, haptens, antibodies, hormones, enzymes, fatty acids, vitamins and drugs.

[0003] The physical structure of the chemiluminescent immunoassay analyzer involves many modules such as filling, mixing, incubation, washing and detection. Among them, the washing module has two main functions: one is to separate the substance to be tested from other substances. This process requires adding washing liquid to the reaction cup, and then the waste liquid is drawn away by the waste liquid needle; the other is to add substrate liquid to the reaction cup. In the process of washing the liquid sample by the washing module, the temperature of the washing liquid, substrate liquid and sample liquid should be appropriate, generally 37°C, to ensure the accuracy of the subsequent detection.

[0004] In the prior art, a heating belt is mainly wrapped around the washing module to heat up the inside of the module, thereby ensuring the ambient temperature of the reaction cup. However, the effect of ensuring the temperature of the liquid in the reaction cup only by the ambient temperature is limited, and the temperature in the cup cannot be well controlled within a relatively ideal range. Summary of the invention

[0005] In view of this, one of the objects of the present invention is to provide a liquid pipe heating device, which can heat the washing liquid pipe and the substrate pipe, so that the washing liquid and the substrate are heated to the required temperature before entering the cup, thereby ensuring that the liquid temperature in the reaction cup can be controlled within an ideal range.

[0006] To achieve the above purpose, the technical solution of the present invention is as follows:

[0007] A liquid pipe heating device, the key of which is: it includes a mounting plate with a heating chamber inside, a pipeline winding block is installed in the heating chamber, the pipeline winding block is used to wind the liquid pipeline, the mounting plate is provided with an inlet and an outlet, the inlet and the outlet are both connected to the heating chamber, and are respectively used to introduce and lead out the liquid pipeline wound on the pipeline winding block; the mounting plate is provided with a heating component for heating the heating chamber.

[0008] Preferably, the heating chamber is a circular chamber, and the pipeline winding block is a fan-shaped block.

[0009] Preferably, five groups of pipeline winding blocks are installed in the heating chamber, four groups of pipeline winding blocks have the same structure and are all used for winding the washing liquid pipeline.

[0010] Preferably, the inlet is opened at the center position of the top of the installation plate, and the inner ends of the five groups of pipeline winding blocks are all provided with arc-shaped notches, and each arc-shaped notch encloses a longitudinal channel having a common center line with the inlet.

[0011] Preferably, the mounting plate comprises a plate body and a plate cover fixedly mounted on the upper end of the plate body.

[0012] Preferably, the heating component is an electric heating belt arranged at the bottom of the mounting plate, and the top of the mounting plate is covered with a foam layer.

[0013] Preferably, the pipeline winding block has an upper rib and a lower rib at the upper and lower ends respectively, and a positioning groove is formed between the upper rib and the lower rib, and the positioning groove surrounds the pipeline winding block circumferentially.

[0014] Preferably, a first fastening block and a second fastening block are detachably mounted in the positioning groove, wherein the first fastening block is located at the upper end of the positioning groove and is used to fix the lead-out section of the liquid pipeline, and the second fastening block is located at the lower end of the positioning groove and is used to fix the lead-in section of the liquid pipeline.

[0015] Preferably, the inlet is equipped with a protective coil.

[0016] The second object of the present invention is to provide a washing module, which includes a base, a circular turntable is rotatably installed in the base, and a ring array of support holes are distributed on the circular turntable for positioning and supporting the reaction cup. The key lies in: the above-mentioned liquid pipe heating device is installed on the base, the mounting plate is located above the circular turntable, the lead-out port is arranged at the outer end of the mounting plate, and an injection needle is installed in the lead-out port, the injection needle has a horizontal section and a longitudinal section extending downward from the outer end of the horizontal section, and the inner end of the horizontal section is located in the heating chamber.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] 1. When the liquid line heating device is applied to the washing module, the heating chamber can heat the washing liquid and substrate to the required temperature in advance, ensuring that the liquid temperature in the reaction cup is controlled within a more precise range, which helps to improve the final detection accuracy of the chemiluminescence immunoassay analyzer.

[0019] 2. When the liquid line heating device is applied to the washing module, liquid can be directly added to the reaction cup through the elbow-shaped injection needle, which can reduce the heat dissipation time of the liquid in the air and further ensure that the liquid temperature in the reaction cup is controlled within the ideal range. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a structural schematic diagram of the liquid pipe heating device (three-dimensional cross-sectional view).

[0021] Figure 2 It is a schematic diagram of the structure of the liquid pipe heating device (the plate cover 1e is hidden).

[0022] Figure 3 It is a schematic diagram of the structure of the pipeline winding block 2.

[0023] Figure 4 It is a schematic diagram of the structure of the washing module (three-dimensional cross-sectional view).

[0024] Figure 5 for Figure 4 A partial enlarged view of point Ⅰ in the middle. DETAILED DESCRIPTION

[0025] The present invention is further described below in conjunction with embodiments and drawings.

[0026] Embodiment 1

[0027] like Figure 1 As shown, a liquid pipe heating device comprises a mounting plate 1, which is composed of a plate body 1d and a plate cover 1e fixedly assembled on the upper end of the plate body 1d. After the plate cover 1e is fixed on the upper end of the plate body 1d, a heating chamber 1a with a hollow structure is formed inside the mounting plate 1. A pipe winding block 2 is installed in the heating chamber 1a. Figure 3 It can be seen that the upper and lower ends of the pipe winding block 2 are respectively provided with an upper rib 2d and a lower rib 2e protruding outward, and a positioning groove 2b is formed between the upper rib 2d and the lower rib 2e, and the positioning groove 2b surrounds the pipe winding block 2. The installation disk 1 is provided with an inlet 1b and an outlet 1c, and the inlet 1b and the outlet 1c are both connected to the heating chamber 1a. The installation disk 1 is also equipped with a heating component 3 for heating the heating chamber 1a.

[0028] Based on the above structural layout of the liquid circuit tube heating device, its working principle is: the liquid pipeline is wound on the positioning groove 2b of the pipeline winding block 2, and the lead-in section and the lead-out section of the liquid pipeline are respectively passed through the introduction port 1b and the lead-out port 1c. When the liquid pipeline provides washing liquid and substrate to the washing module, the heating component 3 heats up the heating chamber 1a, thereby heating the liquid pipeline wound on the pipeline winding block 2, that is, heating the washing liquid or the substrate. Therefore, before the washing liquid and the substrate are injected into the reaction cup 8, the liquid circuit tube heating device provided in this embodiment can heat the liquid temperature to the required temperature in advance, thereby ensuring that the liquid temperature in the reaction cup 8 can be controlled within a precise range, laying a solid foundation for achieving high-precision detection in the later stage. At the same time, arranging the liquid pipeline in the interior of the heating chamber in a winding manner can make the pipeline fully heated and ensure that the liquid is successfully heated to the required temperature.

[0029] Please refer to Figure 2 and 3 As shown, in this embodiment, the mounting plate 1 is a circular structure, the heating chamber 1a inside it is a circular chamber, the pipeline winding block 2 is a fan-shaped block, and five groups of pipeline winding blocks 2 are installed in the heating chamber 1a. Such a design can ensure that the liquid pipe heating device has a high degree of structural compactness and minimal space waste. Among the five groups of pipeline winding blocks 2, four groups of pipeline winding blocks 2 have the same structure and are all used to wind the washing liquid pipeline, and the other pipeline winding block 2 is used to wind the substrate pipeline. With such a design, the washing module can perform four-stage washing. In this embodiment, the difference between different pipeline winding blocks 2 is the difference in the size of the fan, and the rest of the structure is the same.

[0030] For example Figure 1 As shown, the inlet 1b is opened at the center of the disc cover 1e, and the inner ends of the five groups of pipeline winding blocks 2 are all provided with arc-shaped notches 2a, and each arc-shaped notch 2a surrounds a longitudinal channel with the same center line as the inlet 1b. Such a design can ensure that the liquid pipeline wound on the pipeline winding block 2 can pass through the inlet 1b better. Furthermore, in order to protect the liquid pipeline, a protective coil 5 is sleeved at the position of the inlet 1b, and the protective coil 5 is made of soft plastic.

[0031] For example Figure 3 As shown, the first fastening block 21 and the second fastening block 22 are detachably assembled in the positioning groove 2b of the pipeline winding block 2, the second fastening block 22 is located at the lower end of the positioning groove 2b, and the second fastening block 22 has a second constraint groove 22a arranged opposite to the lower retaining edge 2e, and the first fastening block 21 is located at the upper end of the positioning groove 2b, and the first fastening block 21 has a first constraint groove 21a arranged opposite to the upper retaining edge 2d. When winding the liquid pipeline, the second constraint groove 22a fixes the introduction section of the liquid pipeline at the lower end of the positioning groove 2b, and the first constraint groove 21a fixes the lead-out section of the liquid pipeline at the upper end of the positioning groove 2b, which can ensure that the liquid is orderly and evenly wound on the pipeline winding block 2, which helps to ensure the uniformity of heating. Further, in order to facilitate the overall installation of the five groups of pipeline winding blocks 2, the first fastening block 21 and the second fastening block 22 are arranged on the same side of the positioning groove 2b.

[0032] Furthermore, Figure 3As shown, the side of the pipe winding block 2 is provided with a first mounting groove 2f and a second mounting groove 2g, the first mounting groove 2f extends upward from the lower end of the pipe winding block 2 to the upper retaining edge 2d, and the first fastening block 21 is screwed in the first mounting groove 2f. The second mounting groove 2g extends downward from the upper end of the pipe winding block 2 to the lower retaining edge 2e, and the second fastening block 22 is screwed in the second mounting groove 2g. The first fastening block 21 and the second fastening block 22 can be tightened and loosened by turning the screws.

[0033] In order to facilitate fixing the pipe winding block 2 inside the mounting plate 1, a connecting hole 2h extending along the height direction of the pipe winding block 2 is provided, and fixed assembly can be achieved by bolting.

[0034] Please refer to Figure 1 In this embodiment, the heating component 3 preferably adopts an electric heating belt, which is fixed to the bottom of the tray body 1d. Furthermore, the upper side of the tray cover 1e is covered with a foam layer 1g, which can play a role in heat preservation.

[0035] Embodiment 2

[0036] like Figure 4 and 5 As shown, a washing module comprises a base 6, a circular turntable 7 is rotatably mounted in the base 6, and a circular turntable 7 is provided with supporting holes in an annular array, and the supporting holes are used to position and support a reaction cup 8. The upper end of the base 6 is provided with a liquid pipe heating device provided in the first embodiment, and the installation plate 1 of the liquid pipe heating device is located above the circular turntable 7. Figure 1 It can be seen that the outlet 1c is arranged at the outer end of the mounting plate 1, and an injection needle 4 is installed in the outlet 1c. The injection needle 4 has a horizontal section 4a and a longitudinal section 4b extending downward from the outer end of the horizontal section 4a, and the inner end of the horizontal section 4a is located in the heating chamber 1a.

[0037] When using the above washing module, the lead-out section of the washing liquid pipeline or the substrate pipeline is connected to the inner end of the horizontal section 4a. As the circular turntable 7 rotates, the washing liquid or substrate in the pipeline is directly added to the reaction cup 8 through the injection needle 4 under the action of the pressure pump. Adding washing liquid and substrate to the reaction cup in this way has at least two advantages. One is that the washing liquid and substrate have been heated to the required temperature by the heating component 3 before entering the cup. The temperature is usually 37°C, which can ensure that the liquid temperature in the reaction cup is controlled within the ideal range, which helps to ensure the final detection accuracy of the chemiluminescent immunoassay. The second is that the traditional filling needle needs to inject liquid into the reaction cup with the help of a lifting mechanism. The filling needle has a movement stroke, and this process will dissipate a certain amount of heat into the air. Therefore, the liquid outlet of the injection needle 4 is very close to the reaction cup, and direct filling can reduce the heat dissipation time of the liquid in the air, thereby ensuring that the liquid temperature in the reaction cup is controlled within the ideal range.

[0038] Finally, it should be noted that the above description is only a preferred embodiment of the present invention. Under the guidance of the present invention, ordinary technicians in this field can make various similar expressions without violating the purpose and claims of the present invention, and such changes all fall within the scope of protection of the present invention.

Claims

1. A liquid pipe heating device, characterized in that: The invention comprises a mounting plate (1) having a heating chamber (1a) therein, a pipeline winding block (2) being mounted in the heating chamber (1a), the pipeline winding block (2) being used for winding a liquid pipeline, the mounting plate (1) being provided with an inlet (1b) and an outlet (1c), the inlet (1b) and the outlet (1c) being both in communication with the heating chamber (1a) and being used for respectively introducing and leading out a liquid pipeline wound on the pipeline winding block (2); the heating chamber (1a) being a circular chamber, the pipeline winding block (2) being a fan-shaped block, the pipeline winding block (2) being formed with a circumferential positioning groove (2b) surrounding the circumference thereof, the positioning groove (2b) being used for winding a liquid pipeline; The installation plate (1) is provided with a heating component (3) for heating the heating chamber (1a).

2. The liquid pipe heating device according to claim 1, characterized in that: Five groups of pipeline winding blocks (2) are installed in the heating chamber (1a), of which four groups of pipeline winding blocks (2) have the same structure and are all used for winding washing liquid pipelines.

3. The liquid pipe heating device according to claim 2, characterized in that: The inlet (1b) is opened at the center position of the top of the installation plate (1), and the inner ends of the five groups of pipe winding blocks (2) are all provided with arc-shaped notches (2a), and each arc-shaped notch (2a) surrounds a longitudinal channel having a common center line with the inlet (1b).

4. The liquid pipe heating device according to claim 1, characterized in that: The mounting plate (1) comprises a plate body (1d) and a plate cover (1e) fixedly mounted on the upper end of the plate body (1d).

5. The liquid pipe heating device according to claim 1, characterized in that: The heating component (3) is an electric heating belt arranged at the bottom of the mounting plate (1), and the top of the mounting plate (1) is covered with a foam layer (1g).

6. The liquid pipe heating device according to claim 1, characterized in that: The pipeline winding block (2) has an upper rib (2d) and a lower rib (2e) at the upper and lower ends respectively, and a positioning groove (2b) is formed between the upper rib (2d) and the lower rib (2e), and the positioning groove (2b) surrounds the pipeline winding block (2) in a circumferential direction.

7. The liquid pipe heating device according to claim 6, characterized in that: A first fastening block (21) and a second fastening block (22) are detachably mounted in the positioning groove (2b), wherein the first fastening block (21) is located at the upper end of the positioning groove (2b) and is used to fix the lead-out section of the liquid pipeline, and the second fastening block (22) is located at the lower end of the positioning groove (2b) and is used to fix the lead-in section of the liquid pipeline.

8. The liquid pipe heating device according to claim 3, characterized in that: The inlet (1b) is provided with a protective coil (5).

9. A washing module, comprising a base (6), a circular turntable (7) rotatably mounted in the base (6), and support holes distributed in an annular array on the circular turntable (7) for positioning and supporting a reaction cup, characterized in that: The base (6) is mounted with a liquid pipe heating device according to any one of claims 1 to 8, the mounting plate (1) is located above the circular turntable (7), the outlet (1c) is arranged at the outer end of the mounting plate (1), and an injection needle (4) is installed in the outlet (1c), the injection needle (4) has a horizontal section (4a) and a longitudinal section (4b) extending downward from the outer end of the horizontal section (4a), and the inner end of the horizontal section (4a) is located in the heating chamber (1a).

Citation Information

Patent Citations

  • Chemiluminescence immunoassay instrument washing system with uniformly-mixing function

    CN109675889A

  • Liquid path pipe heating device and washing module with same

    CN218395157U