A multi-level electric pulse generating device with adjustable polarity

Abstract

The present invention discloses a multi-level electric pulse generating device with adjustable polarity, which includes a first pulse generating circuit module and a second pulse generating circuit module; the first pulse generating circuit module includes n cascaded first pulse generating circuits, respectively denoted as the first pulse generating circuit P1, the first pulse generating circuit P2, …, the first pulse generating circuit Pn; the second pulse generating circuit module includes m cascaded second pulse generating circuits, respectively denoted as the second pulse generating circuit N1, the second pulse generating circuit N2, …, the second pulse generating circuit Nm; the present invention proposes a multi-level electric pulse generating device with adjustable polarity, which can achieve the purposes of reducing muscle contraction, enhancing biomedical effects, etc. by flexibly adjusting the amplitude, pulse width, polarity and other pulse parameters.

Description

Technical Field

[0001] The present invention relates to the field of pulsed electric fields, and specifically to a multi-level electric pulse generating device with adjustable polarity. Background Art

[0002] The pulsed electric field tissue ablation technology releases high-voltage electric pulses to biological tissues through electrode needles, so as to achieve the purpose of tissue ablation. Its main tissue ablation principles include:

[0003] 1. The high-voltage pulsed electric field changes the membrane structure permeability in cells, including cell membranes, mitochondrial membranes, Golgi apparatuses, nuclear membranes, etc., destroys cell homeostasis, and causes cell necrosis.

[0004] 2. The high-voltage pulsed electric field acts on the interior of cells to form an internal electric treatment effect, causing biomedical effects such as apoptosis and pyroptosis of cells, thereby leading to cell death. The cell debris after death will be phagocytosed by phagocytes in the body. At the same time, the body's immune response occurs, so as to achieve the effect of controlling tumors.

[0005] The existing pulsed electric field tumor treatment technology mainly uses a pulsed form of a unipolar high-voltage pulsed electric field with a pulse width of 5 - 100 μs. When it is used for ablation of human or animal tissues, since the unipolar pulsed current flows through muscle tissues or nerve tissues, it will cause the occurrence of muscle contraction of the body.

[0006] Animal experiment and cell experiment studies show that the amplitude of the electric pulse field strength is related to the cell biomedical effects (electroporation, irreversible electroporation, internal electric treatment effect, etc.) it causes. If too high an amplitude, a relatively large pulse width, or a unipolar pulse is applied, it will cause muscle and nerve to trigger action potentials, resulting in muscle contraction phenomena, increasing the pain of patients in clinical treatment and easily causing electrode needle displacement, leading to inaccurate control of the ablation area.

[0007] The bipolar pulsed electric field can reduce muscle contraction, but its ablation range is smaller than that of the unipolar microsecond pulse. Most of the existing bipolar electric pulse generators can output bipolar symmetric electric pulses, but their pulse width and amplitude cannot be flexibly adjusted within a short time (basically in ms, μs or ns). Summary of the Invention

[0008] The purpose of the present invention is to provide a multi-level electric pulse generating device with adjustable polarity, including a first pulse generating circuit module and a second pulse generating circuit module;

[0009] The first pulse generating circuit module includes n cascaded first pulse generating circuits, which are respectively denoted as the first pulse generating circuit P1, the first pulse generating circuit P2,..., the first pulse generating circuit Pn;

[0010] Among them, the output terminal of the first pulse generation circuit Pn is denoted as the first output terminal; the first output terminal is used to output a positive-polarity multi-level pulse;

[0011] The second pulse generation circuit module includes m cascaded second pulse generation circuits, denoted as the second pulse generation circuit N1, the second pulse generation circuit N2,..., the second pulse generation circuit Nm respectively;

[0012] Among them, the output terminal of the second pulse generation circuit Nm is denoted as the second output terminal; the second output terminal is used to output a negative-polarity multi-level pulse;

[0013] When the first pulse generation circuits are all grounded, the electric pulse generation device outputs a negative-polarity multi-level pulse;

[0014] When the second pulse generation circuits are all grounded, the electric pulse generation device outputs a positive-polarity multi-level pulse;

[0015] When the first pulse generation circuits and the second pulse generation circuits are all not grounded, the electric pulse generation device outputs a bipolar multi-level pulse.

[0016] Furthermore, the integer n≥1, and the integer m≥1.

[0017] Furthermore, the amplitude and pulse width of the multi-level pulse are adjustable.

[0018] Furthermore, the first pulse generation circuit module outputs a positive-polarity multi-level pulse at the first output terminal by adjusting the delay time of the pulses output by each first pulse generation circuit.

[0019] Furthermore, the second pulse generation circuit module outputs a negative-polarity multi-level pulse at the second output terminal by adjusting the delay time of the pulses output by each second pulse generation circuit.

[0020] Furthermore, the waveform of the multi-level pulse includes a square wave, a triangular wave, a stepped wave, and an exponential wave.

[0021] Furthermore, the topological structures of the first pulse generation circuit and the second pulse generation circuit are the same;

[0022] Among them, the topological structure of the i-th first pulse generation circuit is as follows:

[0023] Denote the end where the positive pole of the power supply is located as A, and the end where the negative pole is located as B;

[0024] The A end of the power supply is connected to the anode of the diode Di1; the cathode of the diode Di1 is grounded after being connected in series with the capacitor Ci1; the cathode of the diode Di1 is successively connected in series with the switch Si1 and the switch Si1* and then grounded; i = 2,..., n;

[0025] The cathode of diode Di1 is connected to the second terminal of switch Si2* after being serially connected with switch Si1.

[0026] The anode of diode Dij is serially connected with the cathode of diode Di(j - 1), and the cathode is serially connected with the anode of diode Di(j + 1); j = 2, …, n'; n' is an integer greater than 0.

[0027] The cathode of diode Dij is serially connected with switch Si2 and then connected to the first terminal of switch Si2*.

[0028] The cathode of diode Dij is serially connected with capacitor Cj and then connected to the second terminal of switch Si2*.

[0029] The cathode of diode Din' is serially connected with switch Sn' and then connected to the first terminal of switch Sn'*; the cathode of diode Din' is serially connected with switch Sn' and load RL and then grounded.

[0030] The cathode of diode Din' is serially connected with capacitor Cn' and then connected to the second terminal of switch Sn'*.

[0031] Furthermore, the switch includes a MOSFET switch, an IGBT switch, a relay switch, and a semiconductor MOSFET switch.

[0032] The technical effect of the present invention is beyond doubt. The present invention proposes a multi-level electric pulse generating device with adjustable polarity, which can flexibly adjust parameters such as the amplitude, pulse width, and polarity of the pulse to achieve purposes such as reducing muscle contraction and enhancing biomedical effects.

[0033] The present invention proposes a multi-level electric pulse generating device with adjustable polarity, and parameters such as its amplitude, pulse width, and polarity can be flexibly adjusted within a short time, achieving precise output of parameters.

[0034] Considering that there are differences in the electric pulse amplitude and pulse width tolerated by different patients, the present invention can reduce muscle contraction and electrode needle displacement phenomena by adjusting appropriate electric pulses with amplitude, pulse width, and polarity for patients, and can achieve precise control of the ablation area under a larger and spherical ablation area, and can also reduce the pain of patients in clinical treatment.

[0035] The present invention can output multi-level electric pulses with positive and negative polarities, and its amplitude, pulse width, and polarity can all be flexibly adjusted within a short time. Description of the Drawings

[0036] Figure 1 It is a schematic structural diagram of a multi-level electric pulse generating device with adjustable polarity;

[0037] Figure 2 It is a positive polarity multi-level pulse output mode;

[0038] Figure 3 It is a negative-polarity multi-level pulse output mode;

[0039] Figure 4 It is a schematic diagram of the output waveform (pulse waveforms with multiple amplitudes and multiple pulse widths);

[0040] Figure 5 It is a schematic diagram of the output waveform (pulse waveforms of triangular waves / trapezoidal waves).

[0041] Figure 6 It is the topology of the pulse generation circuit (ordinary switches, including switches such as MOSFETs, IGBTs, and relays);

[0042] Figure 7 It is the topology of the pulse generation circuit (semiconductor MOSFET switch). Specific implementation mode

[0043] The present invention will be further described below in conjunction with embodiments, but it should not be understood that the above-mentioned subject scope of the present invention is limited to the following embodiments. Without departing from the above technical idea of the present invention, various substitutions and changes made according to common general technical knowledge and customary means in the art should be included within the protection scope of the present invention.

[0044] Embodiment 1:

[0045] Refer to Figures 1 to 7 , a multi-level electric pulse generating device with adjustable polarity, including a first pulse generation circuit module and a second pulse generation circuit module;

[0046] The first pulse generation circuit module includes n cascaded first pulse generation circuits, which are respectively denoted as the first pulse generation circuit P1, the first pulse generation circuit P2,..., the first pulse generation circuit Pn;

[0047] Among them, the output terminal of the first pulse generation circuit Pn is denoted as the first output terminal; the first output terminal is used to output positive-polarity multi-level pulses;

[0048] The second pulse generation circuit module includes m cascaded second pulse generation circuits, which are respectively denoted as the second pulse generation circuit N1, the second pulse generation circuit N2,..., the second pulse generation circuit Nm;

[0049] Among them, the output terminal of the second pulse generation circuit Nm is denoted as the second output terminal; the second output terminal is used to output negative-polarity multi-level pulses;

[0050] When all the first pulse generation circuits are grounded, the electric pulse generating device outputs negative-polarity multi-level pulses;

[0051] When all the second pulse generation circuits are grounded, the electric pulse generating device outputs positive-polarity multi-level pulses;

[0052] When neither the first pulse generating circuit nor the second pulse generating circuit is grounded, the electrical pulse generating device outputs bipolar multi-level pulses.

[0053] The integer n ≥ 1 and the integer m ≥ 1.

[0054] The amplitude and pulse width of the multi-level pulses are adjustable.

[0055] The first pulse generating circuit module outputs positive-polarity multi-level pulses at the first output terminal by adjusting the delay time of the pulses output by each first pulse generating circuit.

[0056] The second pulse generating circuit module outputs negative-polarity multi-level pulses at the second output terminal by adjusting the delay time of the pulses output by each second pulse generating circuit.

[0057] The waveforms of the multi-level pulses include square waves, triangular waves, stepped waves, and exponential waves.

[0058] The topological structures of the first pulse generating circuit and the second pulse generating circuit are the same;

[0059] Among them, the topological structure of the i-th first pulse generating circuit is as follows:

[0060] Denote the end where the positive pole of the power supply is located as A and the end where the negative pole is located as B;

[0061] The A end of the power supply is connected to the anode of diode Di1; the cathode of diode Di1 is grounded after being connected in series with capacitor Ci1; the cathode of diode Di1 is connected to the ground after being connected in series with switch Si1 and switch Si1* in sequence; i = 2, …, n;

[0062] The cathode of diode Di1 is connected to the second end of switch Si2* after being connected in series with switch Si1;

[0063] The anode of diode Dij is connected to the cathode of diode Di(j - 1), and the cathode is connected to the anode of diode Di(j + 1); j = 2, …, n'; n' is an integer greater than 0;

[0064] The cathode of diode Dij is connected to the first end of switch Si2* after being connected in series with switch Si2;

[0065] The cathode of diode Dij is connected to the second end of switch Si2* after being connected in series with capacitor Cj;

[0066] The cathode of diode Din' is connected to the first end of switch Sn' after being connected in series with switch Sn'; the cathode of diode Din' is connected to the ground after being connected in series with switch Sn' and load RL;

[0067] The cathode of diode Din’ is connected to the second end of switch Sn’ after being in series with capacitor C n’.

[0068] The switch includes MOSFET switch, IGBT switch, relay switch, semiconductor MOSFET switch.

[0069] Embodiment 2:

[0070] The electric pulse generating device includes a plurality of pulse forming modules, which can achieve multi-level output through cascading, or can achieve bipolar pulses at the output port.

[0071] The output pulse waveform can be multi-level pulses with positive polarity, negative polarity, and bipolarity.

[0072] The waveform of the output pulse can be square wave, triangular wave, stepped wave, exponential wave, etc.

[0073] The electric pulse generating device proposed by the present invention can flexibly adjust the pulse width and flexibly adjust the pulse polarity.

[0074] The electric pulse output method proposed by the present invention can output electric pulses with stepped adjustable polarity (unipolar and bipolar) and multiple amplitudes, and can also output electric pulses with square adjustable polarity (unipolar and bipolar) and multiple amplitudes.

[0075] The electric pulse generating device includes one or more than one pulse generating circuits, such as Figure 1 shown, including pulse generating circuits P1, P2…Pn (n≥1), which can form positive multi-level pulses at the output end; pulse generating circuits N1, N2…Nm (m≥1), which can form negative multi-level pulses at the output end.

[0076] When the output pulse is positive (terminal 1 is the electric pulse and 2 is grounded), as Figure 2 shown, the positive pulse generating circuit Pi (i = 1, 2, …n) will work to output electric pulses, and the pulse amplitude, width, and delay time between pulses output by each pulse generating circuit can all be flexibly adjusted. The negative pulse generating circuit Ni (i = 1, 2, …m) will be switched to ground through the switch, so positive multi-level pulses will be formed at the output end.

[0077] When the output pulse is negative (terminal 1 is grounded and 2 is the electric pulse), as Figure 2 shown, the negative pulse generating circuit Ni (i = 1, 2, …m) will work to output electric pulses, and the pulse amplitude, width, and delay time between pulses output by each pulse generating circuit can all be flexibly adjusted. The positive pulse generating circuit Pi (i = 1, 2, …n) will be switched to ground through the switch, so negative multi-level pulses will be formed at the output end.

[0078] Example 3:

[0079] A multi-level electric pulse generating device with adjustable polarity, comprising a first pulse generating circuit module and a second pulse generating circuit module;

[0080] The first pulse generating circuit module includes n cascaded first pulse generating circuits, respectively denoted as the first pulse generating circuit P1, the first pulse generating circuit P2,..., the first pulse generating circuit Pn;

[0081] Among them, the output terminal of the first pulse generating circuit Pn is denoted as the first output terminal; the first output terminal is used to output positive-polarity multi-level pulses;

[0082] The second pulse generating circuit module includes m cascaded second pulse generating circuits, respectively denoted as the second pulse generating circuit N1, the second pulse generating circuit N2,..., the second pulse generating circuit Nm;

[0083] Among them, the output terminal of the second pulse generating circuit Nm is denoted as the second output terminal; the second output terminal is used to output negative-polarity multi-level pulses;

[0084] When all the first pulse generating circuits are grounded, the electric pulse generating device outputs negative-polarity multi-level pulses;

[0085] When all the second pulse generating circuits are grounded, the electric pulse generating device outputs positive-polarity multi-level pulses;

[0086] When neither the first pulse generating circuit nor the second pulse generating circuit is grounded, the electric pulse generating device outputs bipolar multi-level pulses.

[0087] Example 4:

[0088] A multi-level electric pulse generating device with adjustable polarity, the main content is as in Example 3, where the integer n ≥ 1 and the integer m ≥ 1.

[0089] Example 5:

[0090] A multi-level electric pulse generating device with adjustable polarity, the main content is as in Example 3, where the amplitude and pulse width of the multi-level pulses are adjustable.

[0091] Example 6:

[0092] A multi-level electric pulse generating device with adjustable polarity, the main content is as in Example 3, where the first pulse generating circuit module adjusts the delay time of the pulses output by each first pulse generating circuit, and is used to output positive-polarity multi-level pulses at the first output terminal.

[0093] Example 7:

[0094] A multi-level electric pulse generating device with adjustable polarity, the main content is shown in Embodiment 3. Among them, the second pulse generating circuit module outputs negative multi-level pulses at the second output end by adjusting the delay time of the pulses output by each second pulse generating circuit.

[0095] Embodiment 8:

[0096] A multi-level electric pulse generating device with adjustable polarity, the main content is shown in Embodiment 3. Among them, the waveforms of the multi-level pulses include square waves, triangular waves, stepped waves, and exponential waves.

[0097] Embodiment 9:

[0098] A multi-level electric pulse generating device with adjustable polarity, the main content is shown in Embodiment 3. Among them, the topological structures of the first pulse generating circuit and the second pulse generating circuit are the same;

[0099] Among them, the topological structure of the i-th first pulse generating circuit is as follows:

[0100] Denote the end where the positive pole of the power supply is located as A, and the end where the negative pole is located as B;

[0101] The A end of the power supply is connected to the anode of diode Di1; the cathode of diode Di1 is connected to the ground in series with capacitor Ci1; the cathode of diode Di1 is connected to the ground in series with switch Si1 and switch Si1* in sequence; i = 2,..., n;

[0102] The cathode of diode Di1 is connected to the second end of switch Si2* after being connected in series with switch Si1;

[0103] The anode of diode Dij is connected to the cathode of diode Di(j - 1), and the cathode is connected to the anode of diode Di(j + 1); j = 2,..., n'; n' is an integer greater than 0;

[0104] The cathode of diode Dij is connected to the first end of switch Si2* after being connected in series with switch Si2;

[0105] The cathode of diode Dij is connected to the second end of switch Si2* after being connected in series with capacitor Cj;

[0106] The cathode of diode Din' is connected to the first end of switch Sn' after being connected in series with switch Sn'; the cathode of diode Din' is connected to the ground in series with switch Sn' and load RL;

[0107] The cathode of diode Din' is connected to the second end of switch Sn'* after being connected in series with capacitor Cn'.

[0108] Embodiment 10:

[0109] A multi-level electric pulse generating device with adjustable polarity, the main content can be seen in Embodiment 3. Among them, the switches include MOSFET switches, IGBT switches, relay switches, and semiconductor MOSFET switches.

Claims

1. A multi-level electric pulse generating device with adjustable polarity, characterized in that: It includes a first pulse generating circuit module and a second pulse generating circuit module; The first pulse generating circuit module includes n cascaded first pulse generating circuits, denoted as the first pulse generating circuit P1, the first pulse generating circuit P2,..., the first pulse generating circuit Pn respectively; Among them, the output terminal of the first pulse generating circuit Pn is denoted as the first output terminal; the first output terminal is used to output positive-polarity multi-level pulses; The second pulse generating circuit module includes m cascaded second pulse generating circuits, denoted as the second pulse generating circuit N1, the second pulse generating circuit N2,..., the second pulse generating circuit Nm respectively; Among them, the output terminal of the second pulse generating circuit Nm is denoted as the second output terminal; the second output terminal is used to output negative-polarity multi-level pulses; When all the first pulse generating circuits are grounded, the electric pulse generating device outputs negative-polarity multi-level pulses; When all the second pulse generating circuits are grounded, the electric pulse generating device outputs positive-polarity multi-level pulses; When neither the first pulse generating circuit nor the second pulse generating circuit is grounded, the electric pulse generating device outputs bipolar multi-level pulses; The amplitude and pulse width of the multi-level pulses are adjustable; The negative-polarity pulse generating circuit Ni is grounded through a switch to form a positive-polarity multi-level pulse at the output terminal; i = 1, 2,..., m; The positive-polarity pulse generating circuit Pi is grounded through a switch to form a negative-polarity multi-level pulse at the output terminal; i = 1, 2,..., n; The first pulse generating circuit module adjusts the delay time of the pulses output by each first pulse generating circuit and is used to output positive-polarity multi-level pulses at the first output terminal; The second pulse generating circuit module adjusts the delay time of the pulses output by each second pulse generating circuit and is used to output negative-polarity multi-level pulses at the second output terminal.

2. The multi-level electric pulse generating device with adjustable polarity according to claim 1, characterized in that: The integer n ≥ 1, and the integer m ≥ 1.

3. The multi-level electric pulse generating device with adjustable polarity according to claim 1, characterized in that: The waveforms of the multi-level pulses include square waves, triangular waves, stepped waves, and exponential waves.

4. The multi-level electric pulse generating device with adjustable polarity according to claim 1, characterized in that: The topological structures of the first pulse generating circuit and the second pulse generating circuit are the same; Among them, the topological structure of the i-th first pulse generating circuit is as follows: Denote the end where the positive pole of the power supply is located as A, and the end where the negative pole is located as B; The A end of the power supply is connected to the anode of the diode Di1; the cathode of the diode Di1 is connected to the ground in series with the capacitor Ci1; the cathode of the diode Di1 is connected to the ground in series with the switch Si1 and the switch Si1* in turn; i = 2,..., n; The cathode of the diode Di1 is connected to the second terminal of the switch Si2* after being connected in series with the switch Si1; The anode of the diode Dij is connected to the cathode of the diode Di(j - 1) in series, and the cathode is connected to the anode of the diode Di(j + 1) in series; j = 2,..., n'; n' is an integer greater than 0; The cathode of diode Dij is connected to the first end of switch Si2* after being serially connected with switch Si2; The cathode of diode Dij is connected to the second end of switch Si2* after being serially connected with capacitor Cj; The cathode of diode Din’ is connected to the first end of switch Sn’* after being serially connected with switch Sn’; the cathode of diode Din’ is grounded after being serially connected with switch Sn’ and load RL; The cathode of diode Din’ is connected to the second end of switch Sn’* after being serially connected with capacitor Cn’; 5. A polarity-adjustable multi-level electric pulse generating device according to claim 4, characterized in that: The switch includes a MOSFET switch, an IGBT switch, a relay switch, and a semiconductor MOSFET switch.

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