Application of JWA peptides in the preparation of anti-Parkinson's disease drugs
CN115536753BActive Publication Date: 2026-05-26SUZHOU MINGREN PHARM BIOTECHNOLOGY CO LTD
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SUZHOU MINGREN PHARM BIOTECHNOLOGY CO LTD
- Filing Date
- 2022-09-16
- Publication Date
- 2026-05-26
AI Technical Summary
Technical Problem
Current technologies lack effective treatments for Parkinson's disease, particularly in their inability to effectively inhibit the overactivation of astrocytes and reduce the excitatory neurotoxicity of dopamine neurons, which leads to neuronal death.
Method used
Using JWA peptides with specific amino acid sequences, the integrin molecules are targeted to enter astrocytes in brain tissue, regulating their proliferation and activation, activating GLT-1 expression, inhibiting the NF-κB signaling pathway, and reducing excitotoxicity.
Benefits of technology
It significantly inhibits the excessive activation of astrocytes, enhances the anti-excitatory neurotoxicity of dopamine neurons, and reduces neuronal death, providing a new treatment for Parkinson's disease.
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Figure CN115536753B_ABST
Abstract
This invention relates to the application of JWA polypeptide in the preparation of anti-Parkinson's disease drugs. The amino acid sequence of the polypeptide is shown in I or II: I: FPGSDRF-Z; II: X-FPGSDRF-Z; wherein, amino acid S is phosphorylated, and X and Z are amino acids or amino acid sequences, respectively; X is selected from one of F, (R)9, (R)9-F, 6-aminohexanoic acid, 6-aminohexanoic acid-F, 6-aminohexanoic acid-(R)9, and 6-aminohexanoic acid-(R)9-F; Z is selected from (G) n -RGD, A-(G) n One of the -RGD, where n is an integer greater than or equal to 0, and the value of n ranges from 0 to 10. The above-mentioned peptides can serve as candidate molecules for the treatment or prevention of Parkinson's disease, or for specific symptoms or signs of Parkinson's disease, and have good application prospects.
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