Application of JWA peptides in the preparation of anti-Parkinson's disease drugs

CN115536753BActive Publication Date: 2026-05-26SUZHOU MINGREN PHARM BIOTECHNOLOGY CO LTD
View PDF 3 Cites 0 Cited by

Patent Information

Application Number
CN202211129238.5
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-09-16
Publication Date
2026-05-26
Estimated Expiration
2042-09-16

AI Technical Summary

Technical Problem

Current technologies lack effective treatments for Parkinson's disease, particularly in their inability to effectively inhibit the overactivation of astrocytes and reduce the excitatory neurotoxicity of dopamine neurons, which leads to neuronal death.

Method used

Using JWA peptides with specific amino acid sequences, the integrin molecules are targeted to enter astrocytes in brain tissue, regulating their proliferation and activation, activating GLT-1 expression, inhibiting the NF-κB signaling pathway, and reducing excitotoxicity.

Benefits of technology

It significantly inhibits the excessive activation of astrocytes, enhances the anti-excitatory neurotoxicity of dopamine neurons, and reduces neuronal death, providing a new treatment for Parkinson's disease.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure CN115536753B_ABST
    Figure CN115536753B_ABST
Patent Text Reader

Abstract

This invention relates to the application of JWA polypeptide in the preparation of anti-Parkinson's disease drugs. The amino acid sequence of the polypeptide is shown in I or II: I: FPGSDRF-Z; II: X-FPGSDRF-Z; wherein, amino acid S is phosphorylated, and X and Z are amino acids or amino acid sequences, respectively; X is selected from one of F, (R)9, (R)9-F, 6-aminohexanoic acid, 6-aminohexanoic acid-F, 6-aminohexanoic acid-(R)9, and 6-aminohexanoic acid-(R)9-F; Z is selected from (G) n -RGD, A-(G) n One of the -RGD, where n is an integer greater than or equal to 0, and the value of n ranges from 0 to 10. The above-mentioned peptides can serve as candidate molecules for the treatment or prevention of Parkinson's disease, or for specific symptoms or signs of Parkinson's disease, and have good application prospects.
Need to check novelty before this filing date? Find Prior Art

Citation Information

Patent Citations

  • Polypeptide with anti-tumor activity and application thereof

    CN103239710B

  • Application of JWA polypeptide in preparation of medicine for resisting neovascular eye diseases

    CN114940702A

  • Application of cytoskeleton like gene JWA in inhibiting toxicity of excitatory amino acid for treating Parkinson's diseases

    CN1951503A