An ion collision pyrolysis device and a tandem mass spectrometer

Abstract

This invention discloses an ion collision pyrolysis device and a tandem mass spectrometer, relating to the field of analytical detection equipment. It includes a sleeve, an inlet electrode, an outlet electrode, and an insulating rod. The inlet and outlet electrodes are respectively disposed at both ends of the sleeve. The inlet electrode has an inlet center hole, and the outlet electrode has an outlet center hole. A vent is provided on the side wall of the sleeve. The insulating rod is uniformly fixed inside the sleeve and parallel to the axial direction of the sleeve. A resistive layer formed of a conductive resistive material is disposed on the surface of the insulating rod, which is used to uniformly increase the resistance of the insulating rod with its length. Different DC voltages are applied to the two ends of the insulating rod. This application can provide a uniform axial accelerating electric field, reduce the residence time of ions in the collision cell, increase the scanning speed, and increase the number of ion pairs scanned per unit time. Simultaneously, it is less likely to cause structural deformation and heating effect on ions. Its structure is simple, easy to manufacture, and easy to install.

Description

Technical Field

[0001] This invention relates to the field of analytical testing equipment, and more specifically, to an ion collision pyrolysis device and a tandem mass spectrometer. Background Technology

[0002] Tandem mass spectrometry combines the advantages of high-speed analysis, high sensitivity, high resolution, and high accuracy, offering superior sensitivity and qualitative and quantitative analysis capabilities. It is widely used in the detection of biomolecules such as peptides, proteins, and nucleic acids, as well as in environmental, food, and pharmaceutical fields. During analysis, target ions are selected in a mass filter and then enter a collisional fragmentation device to generate fragment ions, which are then analyzed by the mass analyzer for qualitative and quantitative analysis of the target analyte. The collisional fragmentation device is a key component that directly affects the instrument's analytical speed and performance, including cross-contamination.

[0003] Currently, most ion collision pyrolysis devices employ a multipole (ring) design. In addition to applying an RF voltage, a DC static voltage is also applied to the electrode rods (rings) to create an axial gradient electric field. Commonly used structures include quadrupoles, hexapoles, and octupoles. Besides linear multipole designs, there are also curved (90° or 180°) multipole designs. To reduce the residence time of ions in the device and mitigate crosstalk, an axial electric field needs to be introduced, such as through LINAC multipole structures, tilted multipole structures, or ring electrode structures.

[0004] The LINAC multipole structure reduces the upper limit of transported ion mass due to the presence of a radial component; the tilted multipole structure presents greater challenges in electrode installation; and the ring electrode structure places high demands on the design of the pulse voltage circuit. Furthermore, these methods generally suffer from high fabrication difficulty, complex installation processes, and high costs.

[0005] Therefore, this application is hereby submitted. Summary of the Invention

[0006] The objectives of this invention include, for example, providing an ion collision pyrolysis device and a tandem mass spectrometer.

[0007] The embodiments of the present invention can be implemented as follows:

[0008] In a first aspect, the present invention provides an ion collision pyrolysis device, comprising an inlet electrode, a sleeve, an insulating electrode rod, and an outlet electrode. The inlet electrode and the outlet electrode are respectively disposed at both ends of the sleeve. The inlet electrode is provided with an inlet center hole, and the outlet electrode is provided with an outlet center hole. The side wall of the sleeve is provided with a vent for introducing collision gas. The insulating electrode rod is uniformly fixed inside the sleeve, and the axial direction of the insulating electrode rod is parallel to the axial direction of the sleeve. The surface of the insulating electrode rod is provided with a resistive layer formed of a resistive material with conductive properties. The resistive layer is used to make the resistance of the insulating electrode rod increase uniformly with its length. Different DC voltages are applied to the two ends of the insulating electrode rod.

[0009] In an optional embodiment, the resistivity of the resistive material is 10⁻⁶. -1 ~10 4 Ω·cm.

[0010] In an optional embodiment, the resistive material is a carbon nanofilm or an indium tin oxide film;

[0011] Preferably, the insulating pole is made of ceramic or quartz.

[0012] In an optional embodiment, the thickness of the resistive layer is 20–500 nm.

[0013] In an optional embodiment, the resistive layer is deposited on the surface of the insulating pole using physical vapor deposition or chemical vapor deposition.

[0014] In an optional embodiment, the ion collision pyrolysis device further includes a fixing frame for fixing the insulating pole rod. The fixing frame is annular, with its outer ring fixedly connected to the inner side of the sleeve. The inner ring of the fixing frame is provided with a plurality of mounting grooves, and the insulating pole rod is installed in the mounting grooves.

[0015] Preferably, the number of mounting slots is the same as the value of N in the insulating pole, wherein N is an even number greater than or equal to 4;

[0016] Preferably, the fixing frame is made of insulating material.

[0017] In an optional embodiment, the sleeve includes an outer sleeve and an inner sleeve, the inner sleeve is fitted inside the outer sleeve, the inner sleeve has a mesh structure and is provided with multiple mesh holes, and the inner sleeve is fitted on the outside of the insulating pole.

[0018] Preferably, the outer sleeve is made of an insulating material.

[0019] In an optional embodiment, the DC voltage applied to the end of the insulating pole near the lead-in electrode is less than the DC voltage applied to the end of the insulating pole near the lead-out electrode.

[0020] In an optional embodiment, the insulating poles are connected to each other at intervals to form a pair of poles, and radio frequency voltages with equal amplitude and a phase difference of 180° are applied to the two pairs of poles respectively.

[0021] In a second aspect, the present invention provides a tandem mass spectrometer, which includes an ion collision pyrolysis device as described in any of the foregoing embodiments.

[0022] The beneficial effects of the embodiments of the present invention include, for example:

[0023] This invention provides an ion collision pyrolysis device. By depositing a resistive layer of a conductive resistive material on the outside of an insulating electrode, and applying different static voltages to both ends of the insulating electrode, a uniform axial accelerating electric field can be provided. This reduces the residence time of ions in the collision cell, increases the scanning speed, and improves the number of ion pairs that can be scanned per unit time. Simultaneously, due to the low coefficient of thermal expansion of the insulating electrode, it is less likely to cause structural deformation or heating effect on the ions. The device has a simpler structure, is easier to manufacture, and is easier to install. Tandem mass spectrometers including the above-mentioned ion collision pyrolysis device offer fast analysis speeds and low cross-contamination. Attached Figure Description

[0024] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present invention and should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0025] Figure 1 A schematic diagram of the ion collision pyrolysis device provided in this application;

[0026] Figure 2 A schematic cross-sectional view of the middle section of the ion collision pyrolysis apparatus provided in this application;

[0027] Figure 3 A schematic diagram of the sleeve and the fixing frame of the ion collision pyrolysis device provided in this application;

[0028] Figure 4 A schematic diagram of the radio frequency voltage applied to the insulating electrode of the ion collision pyrolysis device provided in this application;

[0029] Figure 5A schematic diagram of the DC voltage applied to the two ends of the insulating pole of the ion collision pyrolysis device provided in this application, which is equivalent to the series connection of segmented quadrupoles with the same resistance value;

[0030] Figure 6 This is a schematic diagram of the operation of the ion collision pyrolysis device provided in this application.

[0031] Icons: 100-Ion collision pyrolysis device; 110-Sleeve; 111-Ventilation port; 112-Outer sleeve; 113-Inner sleeve; 114-Mesh; 120-Introducing electrode; 121-Introducing center hole; 130-Outgoing electrode; 131-Outgoing center hole; 140-Insulating electrode rod; 141-Resistant layer; 150-Fixing bracket; 151-Mounting groove. Detailed Implementation

[0032] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. The components of the embodiments of the present invention described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0033] Therefore, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the invention without inventive effort are within the scope of protection of the invention.

[0034] It should be noted that similar labels and letters in the following figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures.

[0035] In the description of this invention, it should be noted that if terms such as "upper," "lower," "inner," or "outer" are used to indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship in which the product of this invention is usually placed, they are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this invention.

[0036] Furthermore, the terms "first" and "second" are used only to distinguish descriptions and should not be interpreted as indicating or implying relative importance.

[0037] It should be noted that, where there is no conflict, the features in the embodiments of the present invention can be combined with each other.

[0038] Please refer to Figures 1-6 This embodiment provides an ion collision pyrolysis device 100, which includes a sleeve 110, an inlet electrode 120, an outlet electrode 130, an insulating rod 140, and a fixing frame 150.

[0039] Please see Figure 1 and Figure 2 In this application, the sleeve 110 is cylindrical, and its side wall is provided with a vent 111 for introducing collision gas. The sleeve 110 includes an outer sleeve 112 and an inner sleeve 113. The inner sleeve 113 is fitted inside the outer sleeve 112 and has a mesh structure with multiple mesh holes 114. The inner sleeve 113 is fitted outside the insulating pole 140. After the collision gas is introduced through the vent 111, it enters the gap between the outer sleeve 112 and the inner sleeve 113, and is then evenly dispersed through the multiple mesh holes 114 of the inner sleeve 113, so that the collision gas is introduced into the reaction area more evenly, thereby improving the ion collision pyrolysis efficiency. In this application, the outer sleeve 112 is made of insulating material.

[0040] The inlet electrode 120 and the outlet electrode 130 are respectively disposed at both ends of the sleeve 110. The inlet electrode 120 is provided with an inlet center hole 121, and the outlet electrode 130 is provided with an outlet center hole 131. The target ions enter the sleeve 110 through the inlet center hole 121, are generated into fragment ions by the ion collision pyrolysis device 100, and are finally discharged from the outlet electrode 130.

[0041] Insulating poles 140 are uniformly fixed inside sleeve 110, with the axial direction of the insulating poles 140 parallel to the axial direction of sleeve 110. The space enclosed by the insulating poles 140 serves as a collision pool. In this application, the number of insulating poles 140 is an even number greater than or equal to four, such as a four-pole, six-pole, or eight-pole pole. The insulating poles 140 are made of insulating materials, including but not limited to ceramic or quartz.

[0042] In this application, a resistive layer 141 formed of a conductive resistive material is provided on the surface of the insulating pole 140. The resistive layer 141 is used to make the resistance of the insulating pole 140 increase uniformly with its length. At this time, different DC voltages can be applied to the two ends of the insulating pole 140 (see [reference]). Figure 5 This provides a uniform axial accelerating electric field, which can reduce the residence time of ions in the collision cell and increase the scanning speed.

[0043] Specifically, the DC voltage applied to the end of the insulating pole 140 near the lead-in electrode 120 is higher than the DC voltage applied to the end of the insulating pole 140 near the lead-out electrode 130. Preferably, the DC voltage U1 applied to the end of the insulating pole 140 near the lead-in electrode 120 is -300 to 300V, and in this embodiment, U1 = 60V. The DC voltage U2 applied to the end of the insulating pole 140 near the lead-out electrode 130 is -300 to 300V, and U2 - U1 = -200 to 200V is adjustable.

[0044] In this application, the voltage difference between the two ends of the insulating pole 140 enables ions entering the collision cell to move from the high potential energy inlet end of the insulating pole 140 to the low potential energy outlet end of the insulating pole 140. Since this application forms an axial accelerating electric field in the collision cell, the ions are accelerated out of the collision cell.

[0045] Furthermore, this application requires specifying the exact selection of the conductive resistive material. Assuming the resistive material has a resistivity of 200 Ω·cm, a resistive layer thickness of 20 nm, an electrode diameter of 9 mm, a length of 20 cm, and a DC differential voltage of 10 V applied to the electrode, the DC current on the electrode is approximately 12.5 mA, and the DC power loss is approximately 0.125 watts. This application's research has found that using a resistive material with a resistivity lower than that described in this application results in significant DC power dissipation and electrode heating, while selecting a resistive material with higher resistivity leads to significant RF power dissipation and higher RF drive power supply costs. Therefore, in this application, a carbon nanofilm or indium tin oxide film is preferred as the resistive material.

[0046] Furthermore, the thickness of the resistive layer 141 in this application has a significant impact on the resistance of the insulating pole 140, thereby affecting the electric field strength within the collision cell enclosed by the insulating pole 140. In this application, the thickness of the resistive layer 141 is 20–500 nm.

[0047] In this application, the resistive layer 141 is deposited on the surface of the insulating pole 140. Specifically, the method of depositing the resistive layer 141 on the surface of the insulating pole 140 includes: depositing using physical vapor deposition or chemical vapor deposition. The specific parameters and steps of the depositing can be adjusted according to the actual situation.

[0048] In addition, please see Figure 4 In this application, the insulating poles 140 are spaced apart and connected to form pairs of poles. Radio frequency voltages with equal amplitude and a phase difference of 180° are applied to each pair of poles. The frequency of the radio frequency voltage is 0.1–5 MHz, and the amplitude is 200–5000 V. In this application, by using a given DC and radio frequency voltage, along with the added inert gas, the target analyte can undergo collisional fragmentation, generating fragment ions.

[0049] Please see Figure 1 and Figure 3 The fixing frame 150 is annular, with its outer ring fixedly connected to the inner side of the sleeve 110. The inner ring of the fixing frame 150 has multiple mounting slots 151, into which the insulating pole 140 is installed. The number of mounting slots 151 is the same as the value of N in the insulating pole 140. In this application, the fixing frame 150 is made of an insulating material, such as ceramic. The fixing frame 150 ensures the stable fixation of the insulating pole 140 within the sleeve 110, which is beneficial for the stability of the entire device and for the precision control of the insulating pole 140.

[0050] Please see Figures 1-6 The working principle of the ion collision pyrolysis device 100 provided in this embodiment is as follows: After the collision gas is introduced from the vent 111, it enters the gap between the outer sleeve 112 and the inner sleeve 113, and then is evenly dispersed through multiple meshes 114 of the inner sleeve 113, so that the collision gas is introduced into the reaction area more evenly, thereby improving the ion collision pyrolysis efficiency. The target ions enter the sleeve 110 from the central inlet hole 121. Radio frequency voltages with equal amplitude and a phase difference of 180° are applied to the two pairs of insulating poles 140 respectively. DC voltages with different voltages are applied to the two ends of the insulating poles 140. The resistive layer formed by the coating on the pole is equivalent to the series connection of segmented quadrupoles with the same resistance value, such as... Figure 5 As shown, the target ions entering the sleeve 110 are generated into fragment ions by the ion collision pyrolysis device 100. Applying different DC voltages to the two ends of the insulating pole 140 can generate an axial electric field, which accelerates the extraction of fragment ions and finally discharges them from the extraction electrode 130.

[0051] The following detailed description is based on specific embodiments.

[0052] Example 1

[0053] This embodiment provides an ion collision pyrolysis device 100, which includes a sleeve 110, an inlet electrode 120, an outlet electrode 130, an insulating rod 140, and a fixing frame 150.

[0054] In this embodiment, the sleeve 110 is cylindrical, and a vent 111 for introducing collision gas is provided on the side wall of the sleeve 110. The sleeve 110 includes an outer sleeve 112 and an inner sleeve 113. The vent 111 is opened on the outer sleeve 112, and the inner sleeve 113 is sleeved inside the outer sleeve 112. The inner sleeve 113 has a mesh structure and is provided with multiple mesh holes 114. The inner sleeve 113 is sleeved on the outside of the insulating pole 140.

[0055] The lead-in electrode 120 and the lead-out electrode 130 are respectively disposed at both ends of the sleeve 110. The lead-in electrode 120 is provided with a lead-in center hole 121, and the lead-out electrode 130 is provided with a lead-out center hole 131.

[0056] In this application, the insulating pole 140 is a quadrupole, which is fixed in the sleeve 110 by the fixing bracket 150. The insulating pole 140 is made of ceramic, and the fixing bracket 150 is also made of ceramic. The surface of the insulating pole 140 is provided with a resistive layer 141 with a thickness of 20 nm formed of carbon nanomaterial (resistivity of 200 Ω·cm).

[0057] By applying different DC voltages to the two ends of the insulating pole 140, where the DC voltage U1 applied to the end of the insulating pole 140 near the lead electrode 120 is 60V and the DC voltage U2 applied to the end of the insulating pole 140 near the lead electrode 130 is 50V, U2-U1=10V, the corresponding poles of the insulating pole 140 are connected together, and a pair of radio frequency voltages with equal amplitude and a phase difference of 180° are applied to the two sets of parallel poles respectively.

[0058] Example 2

[0059] This embodiment provides an ion collision pyrolysis device 100, which includes a sleeve 110, an inlet electrode 120, an outlet electrode 130, an insulating rod 140, and a fixing frame 150.

[0060] In this embodiment, the sleeve 110 is cylindrical, and a vent 111 for introducing collision gas is provided on the side wall of the sleeve 110. The sleeve 110 includes an outer sleeve 112 and an inner sleeve 113. The vent 111 is opened on the outer sleeve 112, and the inner sleeve 113 is sleeved inside the outer sleeve 112. The inner sleeve 113 has a mesh structure and is provided with multiple mesh holes 114. The inner sleeve 113 is sleeved on the outside of the insulating pole 140.

[0061] The lead-in electrode 120 and the lead-out electrode 130 are respectively disposed at both ends of the sleeve 110. The lead-in electrode 120 is provided with a lead-in center hole 121, and the lead-out electrode 130 is provided with a lead-out center hole 131.

[0062] In this application, the insulating pole 140 is a quadrupole, which is fixed inside the sleeve 110 by the fixing bracket 150. The insulating pole 140 is made of quartz, and the fixing bracket 150 is also made of quartz. The surface of the insulating pole 140 is coated with indium tin oxide (with a resistivity of 10 Ω·cm). 4 A resistive layer 141 with a thickness of 50 Ω·cm was formed.

[0063] By applying different DC voltages to the two ends of the insulating pole 140, where the DC voltage U1 applied to the end of the insulating pole 140 near the lead electrode 120 is 300V and the DC voltage U2 applied to the end of the insulating pole 140 near the lead electrode 130 is 200V, U2-U1=-100V, the corresponding poles of the insulating pole 140 are connected together, and a pair of radio frequency voltages with equal amplitude and a phase difference of 180° are applied to the two sets of parallel poles respectively.

[0064] Example 3

[0065] This embodiment is basically the same as embodiment 1, except that in this embodiment, the sleeve 110 only includes the outer sleeve 112, and the collision gas is directly introduced from the vent 111 into the middle of the collision pool formed by the insulating pole rod 140.

[0066] Furthermore, this application also examines existing conventional ion collision pyrolysis devices 100, which, compared to the ion collision pyrolysis device 100 provided in this application, have at least the following drawbacks:

[0067] (1) LINAC-I (Linear Acceleration Technology): This technology employs a pole structure with one thick end and one thin end. The thick end (thin end) of one pair of poles and the thin end (thick end) of another pair of poles form the entrance (exit) of the collision cell. In addition to the RF voltage applied to a regular quadrupole, a DC voltage is also applied to the two pairs of poles, creating a gradient electric field along the axis, which accelerates the daughter ions out of the collision cell. Although the greater the potential gradient of the two pairs of poles, the shorter the time for the daughter ions to escape from the collision cell, the presence of the radial component weakens the ion signal and reduces the upper limit of the transported ion mass.

[0068] (2) LINAC-II technology (linear acceleration technology): Based on the traditional quadrupole, a set of specially designed quadrupoles with a T-shaped cross-section is added to generate a potential gradient on the axis. The potential Ua on the axis is determined by the bias voltage Ub on the quadrupole and the voltage UL on the T-shaped quadrupole. The length (d) of the T-shaped short shank decreases as the distance from the collision pool inlet increases. Compared with the traditional axial acceleration technology, LINAC-II technology effectively improves the upper limit of transmission quality. However, the above structure is not easy to implement.

[0069] (3) Inclined multipole collision cell: The electrostatic voltage on the collision cell shield and the electrostatic voltage on the multipole are superimposed on the axis to form a potential gradient. The direction of the potential gradient on the axis can be changed by changing the voltage of the collision cell wall. In addition, the direction of the potential gradient on the axis can be changed with the change of the collision cell wall voltage, thereby realizing the function of an ion trap. However, this structure has high installation requirements.

[0070] (4) Square electrode rod collision pool: A square octupole structure is adopted. The width w of the square electrode decreases as the electrode length increases, so that the distance from the square electrode to the axis also decreases as the length increases, thus achieving the same effect as a tilted cylindrical quadrupole. This technology has high requirements for the driving power supply.

[0071] (5) 90° curved square quadrupole collision cell: Radio frequency voltage is applied to the quadrupole in the curved direction to transmit ions and static voltage controls the ion collision energy. Lens groups are set at the outlet and inlet to focus the ion beam. The square quadrupole can transmit ions with a wider mass range.

[0072] (6) Ring Electrode Collision Cell – This structure employs a series of ring electrode plates. Opposite-phase RF voltages are applied to adjacent electrodes, confining ions near the collision cell axis. Simultaneously, a fixed-value DC voltage is superimposed on the electrodes, providing the parent ions with the set collision energy. In addition, a momentary DC voltage is applied to the electrode plates and then, after a period of time, to the next electrode plate in the ion's direction of travel, and so on. This momentary voltage moves along the ion's direction of travel, forming a traveling wave. This structure can reduce the residence time of ions in the collision cell and reduce the impact of MRM crosstalk; however, this technology is complex, and the design requirements for the pulse voltage circuit are high.

[0073] Furthermore, the present invention also provides a tandem mass spectrometer, which includes an ion collision fragmentation device 100 as described in any of the foregoing embodiments. The tandem mass spectrometer including the aforementioned ion collision fragmentation device 100 offers fast analysis speed and low cross-contamination.

[0074] In summary, this invention provides an ion collision pyrolysis device 100. By depositing a resistive layer 141 of a conductive resistive material on the outside of the insulating electrode 140, and applying different static voltages to both ends of the insulating electrode 140, a uniform axial accelerating electric field can be provided. This reduces the residence time of ions in the collision cell, increases the scanning speed, and improves the number of ion pairs that can be scanned per unit time. Simultaneously, due to the low coefficient of thermal expansion of the insulating electrode 140, it is less likely to cause structural deformation or heating effect on the ions. The device has a simpler structure, is easier to manufacture, and is easier to install. Tandem mass spectrometers including the aforementioned ion collision pyrolysis device 100 offer fast analysis speeds and low cross-contamination.

[0075] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in the present invention should be included within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the scope of the claims.

Claims

1. An ion collision pyrolysis device, characterized in that, It includes a sleeve, an inlet electrode, an outlet electrode, and an insulating pole. The inlet electrode and the outlet electrode are respectively disposed at both ends of the sleeve. The inlet electrode is provided with an inlet center hole, and the outlet electrode is provided with an outlet center hole. The side wall of the sleeve is provided with a vent for introducing collision gas. The insulating pole is uniformly fixed inside the sleeve, and the axial direction of the insulating pole is parallel to the axial direction of the sleeve. The surface of the insulating pole is provided with a resistive layer formed of a resistive material with conductive properties. The resistive layer is used to make the resistance of the insulating pole increase uniformly with its length. Different DC voltages are applied to the two ends of the insulating pole. The sleeve includes an outer sleeve and an inner sleeve. The inner sleeve is fitted inside the outer sleeve and has a mesh structure with multiple mesh holes. The inner sleeve is fitted on the outside of the insulating pole rod. The vent is opened on the outer sleeve.

2. The ion collision pyrolysis device according to claim 1, characterized in that, The resistivity of the resistive material is 10. -1 ~10 4 Ω·cm.

3. The ion collision pyrolysis apparatus according to claim 1, characterized in that, The resistive material is a carbon nanofilm or an indium tin oxide film.

4. The ion collision pyrolysis apparatus according to claim 1, characterized in that, The insulating pole is made of ceramic or quartz.

5. The ion collision pyrolysis apparatus according to claim 1, characterized in that, The thickness of the resistive layer is 20~500nm.

6. The ion collision pyrolysis apparatus according to claim 1, characterized in that, The resistive layer is deposited on the surface of the insulating pole using physical vapor deposition or chemical vapor deposition.

7. The ion collision pyrolysis apparatus according to any one of claims 1-6, characterized in that, The ion collision pyrolysis device further includes a fixing frame for fixing the insulating pole rod. The fixing frame is annular, and the outer ring of the fixing frame is fixedly connected to the inner side of the sleeve. The inner ring of the fixing frame is provided with multiple mounting grooves, and the insulating pole rod is installed in the mounting grooves.

8. The ion collision pyrolysis apparatus according to claim 7, characterized in that, The number of mounting slots is the same as the number of insulating poles, wherein the number of insulating poles is an even number greater than or equal to 4.

9. The ion collision pyrolysis apparatus according to claim 7, characterized in that, The fixing frame is made of insulating material.

10. The ion collision pyrolysis apparatus according to any one of claims 1-6, characterized in that, The outer sleeve is made of insulating material.

11. The ion collision pyrolysis apparatus according to any one of claims 1-6, characterized in that, The DC voltage applied to the end of the insulating pole near the lead-in electrode is less than the DC voltage applied to the end of the insulating pole near the lead-out electrode.

12. The ion collision pyrolysis apparatus according to claim 11, characterized in that, The insulating poles are connected to each other at intervals to form a pair of poles, and radio frequency voltages with equal amplitude and a phase difference of 180° are applied to the two pairs of poles respectively.

13. A tandem mass spectrometer, characterized in that, It includes the ion collision pyrolysis apparatus as described in any one of claims 1-12.

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