An adsorbent resin filling device and a filling process

Abstract

The present application discloses an adsorbent resin filling device and a filling process, which relate to the technical field of blood purification. The adsorbent resin filling device includes an air injection device, a premixing tank, a dispensing tank, a buffer solution injection device, and a buffer solution tank; the dispensing tank is respectively connected and communicated with the premixing tank and the buffer solution tank, and the dispensing tank is provided with a filling port connected to the adsorption column; the air injection device is connected to the premixing tank for injecting air into the premixing tank; the buffer solution injection device is connected between the dispensing tank and the buffer solution tank for injecting the buffer solution in the buffer solution tank into the dispensing tank. The transportation of the material to be filled is carried out by means of air displacement and buffer solution displacement, without using mechanical valves or solenoid valves, avoiding the resin breakage caused by the extrusion of these valve devices on the resin, and can realize full-automatic filling, further improving the filling efficiency, and can also avoid the generation of bubbles, and the overall operation is stable and reliable.

Description

Technical Field

[0001] This application relates to the technical field of blood purification, and particularly relates to an adsorbent resin filling device and a filling process. Background Art

[0002] Blood purification technology refers to the technology of drawing a patient's blood out of the body, removing certain pathogenic substances through a purification device, and then returning it to the patient's body to achieve blood purification for treating diseases. Early progressive kidney diseases, renal failure, uremia, etc. caused by insufficient renal function can all be treated or alleviated by blood purification technology.

[0003] With the continuous development of technology, in recent years, the scope of blood purification treatments such as hemoperfusion, plasma adsorption, and immunoadsorption based on the concept of artificial kidney technology has been continuously expanding. Blood purification technologies such as hemoperfusion and plasma adsorption: usually involve contacting blood or plasma with a solid-phase adsorbent, and after the solid-phase adsorbent adsorbs harmful substances in the blood or plasma, the purified blood is transfused back into the patient's body.

[0004] The adsorbent material generally uses a resin-based carrier, which is filled in an adsorption column to process blood or plasma. To avoid adverse reactions in patients during use, strict control of microorganisms, endotoxins, etc. is required during adsorbent filling, and it is required to have no visible foreign matter and no micro-particles. Therefore, complete mechanical filling cannot be used for adsorbent filling, and currently, a mixed method of manual and mechanical filling is mostly used to ensure that the adsorbent particles will not be damaged, and at the same time, to ensure that microorganisms, endotoxins, and visible foreign matters will not exceed the standard. However, this mixed method of manual and mechanical filling still has the problem of low filling efficiency.

[0005] The filling amount of the adsorbent also affects the adsorption effect. If the filling amount of the adsorbent is insufficient, the adsorption effect of the adsorption column cannot meet the usage requirements; while if the filling amount of the adsorbent is excessive, it is easy to cause the adsorbent particles to break due to extrusion, or break through the filter membrane, resulting in damage to the filter membrane and affecting the normal use of the hemoperfusion cartridge. Currently, to achieve accurate filling amount, usually before adsorbent filling, a metering device is added to meter the adsorbent and then fill it into the adsorption column. The operation process is cumbersome, and the additional steps are likely to cause damage to the adsorbent, thereby affecting the filling quality of the adsorption column. Summary of the Invention

[0006] In view of this, the purpose of this application is to provide an adsorbent resin filling device and a filling process to solve the technical problems existing in the background art.

[0007] To achieve the above technical purpose, this application provides an adsorbent resin filling device, including an air injection device, a premixing tank, a dispensing tank, a buffer injection device, and a buffer tank;

[0008] The dispensing tank is respectively connected and communicated with the premixing tank and the buffer tank, and the dispensing tank is provided with a filling port connected to the adsorption column;

[0009] The air injection device is connected to the premixing tank and is used for injecting air into the premixing tank;

[0010] The buffer injection device is connected between the dispensing tank and the buffer tank and is used for injecting the buffer solution in the buffer tank into the dispensing tank.

[0011] Further, the diameter of the filling port is not greater than 15 mm.

[0012] Further, the premixing tank, the dispensing tank and the buffer tank are all connected with sterilization connecting pipes for connecting sterilization equipment.

[0013] Further, it further includes a liquid level detector, and the liquid level detector is a capacitance liquid level detector or a photoelectric liquid level sensor;

[0014] The liquid level detector is installed on the pipeline at the top of the dispensing tank and is used for detecting whether the dispensing tank is full.

[0015] Further, the bottom of the dispensing tank is in an inverted cone shape, and the cone angle is 30° to 120°.

[0016] Further, the filling port is arranged at the bottom of the dispensing tank.

[0017] Further, a liquid discharging device is installed at the bottom of the adsorption column.

[0018] Further, the air injection device is an air compressor.

[0019] Further, the buffer injection device is a flow control device;

[0020] The flow control device includes a controller and a metering pump connected to the controller. The controller is used for controlling the metering pump to inject a preset volume of buffer solution into the dispensing tank based on the volume metering method; or

[0021] The flow control device includes a controller, a timer connected to the controller, and a constant flow pump connected to the controller. The controller is used for controlling the constant flow pump to inject buffer solution into the dispensing tank for a preset time through the timer.

[0022] This application also discloses a filling process applied to the above-mentioned adsorbent resin filling device, including the steps:

[0023] After premixing the resin and the buffer solution in the premixing tank, air is injected into the premixing tank through an air injection device to press the premixed material in the premixing tank into the dispensing tank;

[0024] After the premixed material pressed into the dispensing tank is allowed to stand for a preset time, the buffer solution in the buffer solution tank is injected into the dispensing tank through a buffer solution injection device until the dispensing tank is filled;

[0025] With the dispensing tank in a closed state, the filling port of the dispensing tank is opened to discharge a part of the mixed material in the dispensing tank, so that the dispensing tank reaches a negative pressure self-balanced state;

[0026] The buffer solution in the buffer solution tank is injected into the dispensing tank in a preset amount through a buffer solution injection device to press the material to be filled in the dispensing tank into the adsorption column in a preset amount.

[0027] As can be seen from the above technical solutions, the adsorbent resin filling device designed in this application transports the material to be filled by means of air replacement and buffer solution replacement respectively, without using mechanical valves or solenoid valves, avoiding resin breakage caused by the extrusion of these valve devices by the resin. Moreover, the above design can achieve fully automatic filling without manual operation, further improving the filling efficiency. Furthermore, by combining the premixing tank and the dispensing tank, the buffer solution and the resin are premixed in the premixing tank first, and then the premixed material is transported to the dispensing tank for standing. Even if there are bubbles in the premixed material during the transportation process, the bubbles can be removed by standing and settling in the dispensing tank. Description of the Drawings

[0028] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the drawings in the following description are only some embodiments of the present application. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0029] Figure 1 It is a schematic structural diagram of an adsorbent resin filling device provided in the present application;

[0030] Figure 2 It is a flowchart of a filling process provided in the present application;

[0031] In the figure: 1, premixing tank; 2, dispensing tank; 21, filling port; 3, buffer injection device; 4, buffer tank; 51, first connecting pipe; 52, second connecting pipe; 61, air input pipe; 62, first output pipe; 63, second output pipe; 64, pressure controller; 7, sterilization connecting pipe; 71, SIP connecting pipe; 72, CIP connecting pipe; 8, adsorption column; 9, detachable connecting port; 10, liquid level detector; k1, first switching valve; k2, second switching valve; k4, fourth switching valve; k5, fifth switching valve; k6, sixth switching valve; k7, seventh switching valve. Detailed implementation manners

[0032] The technical solutions of the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings. Apparently, the described embodiments are some, but not all, of the embodiments of the present application. All other embodiments obtained by those of ordinary skill in the art based on the embodiments in the present application without creative efforts shall fall within the protection scope of the embodiments of the present application.

[0033] In the description of the embodiments of the present application, it should be noted that the orientation or positional relationship indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. is based on the orientation or positional relationship shown in the accompanying drawings, and is only for the convenience of describing the embodiments of the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation to the embodiments of the present application. In addition, the terms "first", "second", and "third" are only used for descriptive purposes and cannot be construed as indicating or implying relative importance.

[0034] In the description of the embodiments of the present application, it should be noted that unless otherwise clearly specified and limited, the terms "installation", "connection", and "connection" should be understood in a broad sense. For example, it can be a fixed connection, a replaceable connection, or an integral connection. It can be a mechanical connection or an electrical connection. It can be directly connected or indirectly connected through an intermediate medium. It can be the communication inside two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the embodiments of the present application can be understood according to specific situations.

[0035] The embodiments of the present application disclose an adsorbent resin filling device.

[0036] Please refer to Figure 1 , an embodiment of an adsorbent resin filling device provided in the embodiments of the present application includes:

[0037] An air injection device (not shown in the figure), a premixing tank 1, a dispensing tank 2, a buffer injection device 3, and a buffer tank 4.

[0038] The dispensing tank 2 is connected and communicated with the premixing tank 1 through the first connecting pipe 51, and is connected and communicated with the buffer tank 4 through the second connecting pipe 52. In order to facilitate the airtight control of the dispensing tank 2, a manually or electrically controlled first on-off valve k1 is arranged on the first connecting pipe 51, and a manually or electrically controlled second on-off valve k2 is arranged on the second connecting pipe 52.

[0039] Furthermore, the dispensing tank 2 is provided with a filling port 21 connected to the adsorption column 8 to realize filling the adsorption column 8 through the filling port 21, and a corresponding manually or electrically controlled third on-off valve (not shown in the figure) is also arranged on the filling port 21.

[0040] The premixing tank 1 is provided with an air input pipe 61 for connecting an air injection device. A manually or electrically controlled fourth on-off valve k4 is arranged on the air input pipe 61. In order to better control the air pressure in the premixing tank 1, a pressure controller 64 is also arranged on the air input pipe 61 to control the injection of air. The air injection device is connected to the premixing tank 1 through the air input pipe 61 and is used to inject air into the premixing tank 1.

[0041] The buffer injection device 3 is arranged on the second connecting pipe 52 and is used to inject the buffer solution in the buffer tank 4 into the dispensing tank 2.

[0042] It can be seen from the above technical solutions that the adsorbent resin filling device designed in this application transports the resin by means of air displacement and buffer solution displacement respectively, without using mechanical valves or solenoid valves, avoiding the resin breakage caused by the extrusion of these valve devices. Moreover, the above design can realize fully automatic filling without manual operation, further improving the filling efficiency. Furthermore, the premixing tank 1 and the dispensing tank 2 are used in combination. First, the buffer solution and the resin are premixed in the premixing tank 1, and then the premixed material is transported to the dispensing tank 2 for standing. Even if there are bubbles in the premixed material during the transportation process, the bubbles can be removed by standing and settling in the dispensing tank 2.

[0043] The above is the first embodiment of an adsorbent resin filling device provided by this application. The following is the second embodiment of an adsorbent resin filling device provided by this application. For details, please refer to Figure 1 。

[0044] Based on the solution of the above first embodiment:

[0045] Furthermore, the diameter of the filling port 21 is preferably designed to be not greater than 15 mm. This can ensure that the flow rate of the resin at the filling port 21 is appropriate, and it will not be affected by a large mechanical force during the overall filling process, and no breakage will occur to form fine particles.

[0046] Further, sterilization connecting pipes 7 for connecting sterilization equipment are connected to the premixing tank 1, the dispensing tank 2, and the buffer tank 4. The sterilization equipment includes a CIP sterilization equipment and / or a SIP sterilization equipment. Therefore, the sterilization connecting pipe 7 includes a CIP connecting pipe 72 and / or a SIP connecting pipe 71. By connecting to the sterilization equipment, disinfection can be performed online as required, reducing the risk of bacteria and mold mixing in. The premixing tank 1, the dispensing tank 2, and the buffer tank can all be connected to the CIP connecting pipe 72 and the SIP connecting pipe 71 at the top, and both the CIP connecting pipe 72 and the SIP connecting pipe 71 are equipped with manual or electrically controlled fifth switching valves k5. A first output pipe 62 is provided at the bottom of the premixing tank 1. One end of the first connecting pipe 51 is connected to the first output pipe 62, and manual or electrically controlled sixth switching valves k6 are respectively arranged on both sides of the connection of the first output pipe 62 to the first connecting pipe 51. A second output pipe 63 is connected to the bottom of the buffer tank 4. One end of the second connecting pipe 52 is connected to the second output pipe 63, and manual or electrically controlled seventh switching valves k7 are arranged on both sides of the connection of the second output pipe 63 to the second connecting pipe 52.

[0047] Further, the filling port 21 can also be connected to a sterilization equipment with a detachable connection port 9 as required.

[0048] Further, a liquid level detector 10 is further included. The liquid level detector 10 can be a capacitance liquid level detector or a photoelectric liquid level detector. The liquid level detector is installed on the top pipeline of the dispensing tank 2 for detecting whether the dispensing tank 2 is full. Taking the example that the top of the dispensing tank 2 is connected to the SIP connecting pipe 71 or the CIP connecting pipe 72, then the liquid level detector 10 can be configured on the SIP connecting pipe 71 or the CIP connecting pipe 72 connected to the dispensing tank 2. Taking the SIP connecting pipe 71 as an example, there can be two fifth switching valves k5 on the SIP connecting pipe 71, which are respectively arranged on both sides of the liquid level sensor 10.

[0049] Further, the bottom of the dispensing tank 2 is preferably designed to be inverted conical, and the cone angle can be 30° to 120°. This design can better realize the discharge of the materials in the dispensing tank 2. Taking this as an example, the filling port 21 can be arranged at the bottom of the dispensing tank 2.

[0050] Further, a liquid discharging device is installed at the bottom of the adsorption column 8, which can discharge the excess liquid in the adsorption column 8. The liquid discharging device can be a liquid discharging pipe with a corresponding switching valve, and specific limitations are not made.

[0051] Further, the air injection device is preferably designed as an air compressor.

[0052] Furthermore, the buffer injection device 3 is preferably designed as a flow control device. This flow control device can be used according to needs with existing flow controllers on the market. Specifically, this flow control device may include a controller and a metering pump connected to the controller; the controller controls the injection flow rate using the volumetric metering method, that is, the controller controls the metering pump to inject buffer solution into the dispensing tank 2. When the accumulated volume of the injected buffer liquid reaches the preset volume, it is regarded as meeting the set buffer solution volume, and the injection stops. This flow control device may also include a controller, a timer connected to the controller, and a constant flow pump connected to the controller; the controller controls the time for the constant flow pump to inject buffer solution into the dispensing tank 2 through the timer. When the preset time is reached, it can be regarded as meeting the set buffer solution volume, and the injection stops. It can be understood that this flow control device can control the injection volume of the buffer solution based on the volumetric metering method or the constant flow timing method.

[0053] Generally speaking, the adsorbent resin filling device designed in this application has the following advantages:

[0054] 1. It can achieve the full-automatic filling of adsorbent resin without manual operation, shortening the operation time. At the same time, the premixing tank 1, the dispensing tank 2, the buffer tank 4, and the filling port 21 can all be connected to the sterilization equipment, and thus can be sterilized online according to requirements, reducing the risk of bacteria and toxins mixing in.

[0055] 2. The buffer tank 4 controls the amount of buffer solution entering the dispensing tank 2 through the flow control device, thereby controlling the amount of adsorbent filled into the adsorption column 8 in the dispensing tank 2, achieving precise filling of the adsorbent. Moreover, the static operation can be carried out using the dispensing tank 2, so that the resin always settles at the bottom of the dispensing tank 2, and the solid-liquid mixture discharged from the filling port 21 has a stable solid content, ensuring that the solid content fluctuation during continuous filling is within 3%.

[0056] 3. The premixed material is directly pumped from the premixing tank 1 into the dispensing tank 2 through an air compressor. At the same time, the filling port 21 of the dispensing tank 2 has no valve seal during the filling process and maintains negative pressure self-balanced sealing through airtightness. The diameter of the filling port 21 is not higher than 15 mm, and the flow rate is appropriate. The resin in the premixed material is not affected by a large mechanical force during the entire filling process, will not be damaged, and will not form fine particles.

[0057] 4. When the dispensing tank 2 is filled with buffer solution, it remains airtight without air residue; when the buffer solution enters the dispensing tank 2, if there are bubbles, they will directly float up, reducing the risk of air bubbles mixing into the adsorption column 8 during the filling process.

[0058] As Figure 2 shown, this application also discloses a filling process for an adsorbent resin filling device applied to the above embodiment, including the steps:

[0059] S1. After premixing the resin in the premixing tank 1 with the buffer solution, inject air into the premixing tank 1 through the air injection device to press the premixed material in the premixing tank 1 into the dispensing tank 2. It should be noted that premixing is achieved by adding the buffer solution and the resin into the premixing tank 1.

[0060] S2. After the premixed material pressed into the dispensing tank 2 is left standing for a preset time, inject the buffer solution in the buffer solution tank 4 into the dispensing tank 2 through the buffer solution injection device 3 until the dispensing tank 2 is full. It should be noted that taking the liquid level sensor as an example, when the buffer solution is injected into the dispensing tank 2 until the liquid level sensor is triggered, it can be regarded as full and the liquid injection stops.

[0061] S3. Open the filling port 21 of the dispensing tank 2 in a closed state to discharge part of the mixed material in the dispensing tank 2, so that the dispensing tank 2 reaches the negative pressure self - balance state. It should be noted that when the dispensing tank 2 reaches the negative pressure self - balance state, the filling port 21 will no longer drip.

[0062] S4. Inject the buffer solution in the buffer solution tank 4 into the dispensing tank 2 in a preset amount through the buffer solution injection device 3 to press the material to be filled in the dispensing tank 2 into the adsorption column 8 in a preset amount. It should be noted that the injection of the buffer solution is controlled quantitatively according to the preset amount by using the buffer solution injection control. While the buffer solution is being injected, the same volume of material is discharged from the filling port 21 into the adsorption column 8 to achieve displacement filling. When the injection of the buffer solution stops, the filling at the filling port 21 also stops.

[0063] Repeat the above steps S1 - S4 until the resin material in the dispensing tank 2 is consumed.

[0064] The above has introduced in detail an adsorbent resin filling device and a filling process provided by the present application. For those of ordinary skill in the art, according to the idea of the embodiments of the present application, there will be changes in the specific implementation manners and application scopes. In summary, the content of this specification should not be construed as a limitation to the present application.

Claims

1. An adsorbent resin filling device, characterized in that, It includes an air injection device, a premixing tank (1), a dispensing tank (2), a buffer injection device (3) and a buffer tank (4); The dispensing tank (2) is respectively connected and communicated with the premixing tank (1) and the buffer tank (4), and the dispensing tank (2) is provided with a filling port (21) connected to the adsorption column (8); The air injection device is connected to the premixing tank (1) for injecting air into the premixing tank (1); The buffer injection device (3) is connected between the dispensing tank (2) and the buffer tank (4) for injecting the buffer solution in the buffer tank (4) into the dispensing tank (2).

2. The adsorbent resin filling device according to claim 1, characterized in that, The diameter of the filling port (21) is not greater than 15 mm.

3. The adsorbent resin filling device according to claim 1, characterized in that Sterilization connecting pipes (7) for connecting sterilization equipment are connected to the premixing tank (1), the dispensing tank (2) and the buffer tank (4).

4. The adsorbent resin filling device according to claim 1, characterized in that, It further includes a liquid level detector (10), and the liquid level detector (10) is a capacitance liquid level detector or an optoelectronic liquid level sensor; The liquid level detector (10) is installed on the top pipeline of the dispensing tank (2) for detecting whether the dispensing tank (2) is full.

5. The adsorbent resin filling device according to claim 1, characterized in that, The bottom of the dispensing tank (2) is in an inverted cone shape, and the cone angle is 30° to 120°.

6. The adsorbent resin filling device according to claim 5, wherein, The filling port (21) is arranged at the bottom of the dispensing tank (2).

7. The adsorbent resin filling device according to claim 1, characterized in that, A liquid discharge device is installed at the bottom of the adsorption column (8).

8. The adsorbent resin filling device according to claim 1, characterized in that, The air injection device is an air compressor.

9. The adsorbent resin filling device according to claim 1, characterized in that, The buffer injection device (3) is a flow control device; The flow control device includes a controller and a metering pump connected to the controller. The controller is used to control the metering pump to inject a preset volume of buffer solution into the dispensing tank based on the volume metering method; or The flow control device includes a controller, a timer connected to the controller and a constant flow pump connected to the controller. The controller is used to control the constant flow pump to inject buffer solution into the dispensing tank for a preset time through the timer.

10. A filling process applied to the filling device of the adsorbent resin as described in any one of claims 1 to 9, characterized in that, It includes steps: After premixing the resin and the buffer solution in the premixing tank (1), inject air into the premixing tank (1) through the air injection device to press the premixed material in the premixing tank (1) into the dispensing tank (2); After the premixed material pressed into the dispensing tank (2) is left standing for a preset time, inject the buffer solution in the buffer tank (4) into the dispensing tank (2) through the buffer injection device (3) until the dispensing tank (2) is full; Open the filling port (21) of the dispensing tank (2) in a closed state of the dispensing tank (2) to discharge part of the mixed material in the dispensing tank (2) so that the dispensing tank (2) reaches a negative pressure self-balanced state; Inject the buffer solution in the buffer tank (4) into the dispensing tank (2) according to a preset amount through the buffer injection device (3) to press the material to be filled in the dispensing tank (2) into the adsorption column (8) according to a preset amount.

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