Continuous Flow Synthesis Equipment

Abstract

The present invention relates to a continuous flow synthesis equipment, comprising: a plurality of reactors; a transmission pipeline network, comprising a plurality of interconnected connection nodes, and each connection node can be controllably connected to or disconnected from an adjacent connection node; each reactor is connected to one or more of the connection nodes, so that any two reactors can be connected to or disconnected from each other. The above-mentioned continuous flow synthesis equipment connects all the reactors through the transmission pipeline network. When the process flow needs to be changed, there is no need to dismantle the pipeline, and only the corresponding connection nodes need to be controlled so that the two connection nodes connected to the two reactors can be connected to each other, and the two reactors can be connected to each other to transmit materials. If the two connection nodes connected to the two reactors are controlled to be disconnected from each other, the two reactors can be disconnected from each other, no interference will occur, and there is no need to disassemble and reinstall the pipeline, which greatly reduces the cost of changing the process flow of the continuous flow synthesis equipment.

Description

Technical Field

[0001] The invention relates to the technical field of chemical synthesis equipment, in particular to a continuous flow synthesis equipment. Background Art

[0002] Continuous flow synthesis, also known as continuous flow chemistry, refers to the continuous entry of reactants into the reaction site and the reaction for a period of time before the product continuously flows out. Continuous flow synthesis is efficient and easy to install. The efficiency of the reaction is reflected in the rapid and full mixing and contact reaction of the reactants in a limited reaction area, while the safety of the reaction is reflected in the rapid dissipation of the reaction heat through the relatively large surface area of ​​the reaction area. In a short period of time, a small amount of reactants passes through the reaction site, and even if a fault occurs, the small amount of material in the reaction site can be handled in time.

[0003] Traditional continuous flow synthesis equipment mainly consists of track-laying and column reactors. Liquids and reactants in these reactors generally flow into or out of the equipment using straight-through pipes. If the process flow of continuous flow synthesis needs to be changed, all pipes need to be dismantled and reconnected, which greatly increases the cost of changing the process flow of continuous flow synthesis equipment. Summary of the invention

[0004] Based on this, it is necessary to provide a continuous flow synthesis device that improves the above defects in order to change the process flow of continuous flow synthesis, which requires all pipelines to be dismantled and reconnected.

[0005] A continuous flow synthesis device, comprising:

[0006] Multiple reactors;

[0007] The transmission pipeline network includes a plurality of interconnected connection nodes, and each of the connection nodes can be controlled to be connected to or disconnected from the adjacent connection nodes;

[0008] Each of the reactors is connected to one or more of the connection nodes, so that any two reactors can be connected or disconnected with each other.

[0009] In one embodiment, each of the connection nodes can be connected to any other connection nodes through at least two paths.

[0010] In one embodiment, the transmission pipe network includes a plurality of honeycomb units, the pipes in each honeycomb unit are connected end to end, the pipes of all the honeycomb units are interconnected to form a honeycomb structure, and each of the connection nodes is located on one of the honeycomb units.

[0011] In one of the embodiments, the transmission pipeline network includes a plurality of adapters and a plurality of connecting pipes, all of the adapters and all of the connecting pipes are spliced ​​together to form the honeycomb structure, and each of the adapters is provided with the connecting node.

[0012] In one of the embodiments, the connecting pipes of each honeycomb unit are spliced ​​together to form a hexagon, and the adapter is provided at the corner of each honeycomb unit.

[0013] In one embodiment, the continuous flow synthesis device further comprises a three-way valve, which is installed on the adapter to controllably connect or disconnect any two of the three connecting pipes connected to the adapter.

[0014] In one embodiment, the continuous flow synthesis device further comprises a mounting seat, the bottom of the mounting seat is mounted with the transmission pipe network, and the top of the mounting seat is mounted with all the reactors;

[0015] Wherein, the continuous flow synthesis equipment also includes a plurality of connection joints installed on the top of the mounting seat, all of the connection joints are connected to all of the connection nodes in a one-to-one correspondence, and each of the reactors is connected to one or more of the connection joints.

[0016] In one of the embodiments, the continuous flow synthesis device further comprises a cover, which is mounted on the top of the mounting seat and is used to close at least one of the connecting joints.

[0017] In one of the embodiments, when the connection joint is closed by the cover, the cover extends into the connection joint and closes the connection node corresponding to the connection joint, so that the connection node is disconnected from the adjacent connection nodes.

[0018] In one of the embodiments, the continuous flow synthesis device further includes an inlet and outlet liquid connector, which is mounted on the mounting seat and is connected to the transmission pipeline network.

[0019] The above-mentioned continuous flow synthesis equipment connects all the reactors through the transmission pipe network. When the process needs to be changed, there is no need to remove the pipeline. It is only necessary to control the corresponding connection node so that the two connection nodes connected to the two reactors can be connected to each other, and the two reactors can be connected to each other to transmit materials. If the two connection nodes connected to the two reactors are disconnected from each other, the two reactors can be disconnected from each other and no interference will occur. In this way, when the continuous flow synthesis equipment needs to change the process, it is only necessary to control the connection and disconnection of the connection node with other connection nodes, without the need to disassemble and install the pipeline again, which greatly reduces the cost of changing the process of the continuous flow synthesis equipment. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a structural schematic diagram of a continuous flow synthesis device in one embodiment of the present invention;

[0021] Figure 2 for Figure 1 A schematic diagram of the structure of the transmission pipeline network in the embodiment.

[0022] Low temperature reactor 10; ultra-high temperature fixed bed reactor 11; PTFE high temperature reactor 12; liquid-liquid separator 13;

[0023] Transmission network 20; connection node 21; honeycomb unit 22; adapter 23; connection pipeline 24;

[0024] Mounting seat 30; three-way valve 31; sealing cover 32; inlet and outlet liquid joints 33. DETAILED DESCRIPTION

[0025] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific embodiments of the present invention are described in detail below in conjunction with the accompanying drawings. In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present invention, so the present invention is not limited by the specific embodiments disclosed below.

[0026] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0027] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In the description of the present invention, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0028] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0029] In the present invention, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may mean that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediate medium. Moreover, a first feature being "above", "above" or "above" a second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. A first feature being "below", "below" or "below" a second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0030] It should be noted that when an element is referred to as being "fixed to" or "disposed on" another element, it may be directly on the other element or there may be a central element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. The terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used herein are for illustrative purposes only and are not intended to be the only implementation method.

[0031] See also Figure 1 and Figure 2 An embodiment of the present invention provides a continuous flow synthesis device, including a reactor and a transmission pipeline network 20. The reactor includes multiple reactors, namely the low-temperature reactor 10, the ultra-high temperature fixed bed reactor 11, and the PTFE high-temperature reactor 12 described below. The transmission pipeline network 20 is connected to all the reactors so that all the reactors are interconnected through the transmission pipeline network 20, so that the reactants produced in one of the reactors can be transported to other reactors through the transmission pipeline network 20.

[0032] The transmission pipe network 20 includes a plurality of interconnected connection nodes 21, and each reactor is connected to one or more of the connection nodes 21. Since each connection node 21 is interconnected with other connection nodes 21, any two reactors among all the reactors can be interconnected through the transmission pipe network 20. Furthermore, each connection node 21 can be controllably connected or disconnected with adjacent connection nodes 21. By disconnecting two connection nodes 21 from each other, the reactors connected to the two connection nodes 21 can be disconnected from each other, so as to prevent two reactors that do not need to be connected from being connected to each other.

[0033] In actual use, if the process flow of the continuous flow synthesis equipment needs to be changed, the connection relationship between all reactors needs to be changed. For example, two reactors that were originally connected to each other need to be disconnected from each other, and two reactors that were originally disconnected need to be connected to each other. According to traditional continuous flow synthesis equipment, all pipelines must be dismantled and then rearranged, which is time-consuming and labor-intensive.

[0034] In the above-mentioned continuous flow synthesis equipment, all the reactors have been interconnected through the transmission pipe network 20, that is, any two reactors have been connected to each other through the transmission pipe network 20. When the process flow of the continuous flow synthesis equipment needs to be changed, when the two reactors that were originally disconnected need to be connected to each other, since any two reactors are already connected to each other, there is no need to re-establish a pipeline connection between the two reactors, and it is only necessary to control the connection nodes 21 connected to the two reactors to be connected to each other. Specifically, the operator finds the connection node 21 corresponding to the two reactors, and controls the connection node 21 to be connected to the adjacent connection node 21, and then controls the connection node 21 adjacent to the connection node 21 to be connected to other connection nodes 21, and repeats until the two connection nodes 21 corresponding to the two reactors are connected to each other, and the connection between the two reactors is completed.

[0035] Furthermore, in order to avoid the connection between two unrelated reactors, it is only necessary to control the connection nodes 21 connected to the two reactors to be disconnected from each other. For example, the operator can control the two connection nodes 21 connected to the two reactors to be disconnected from the adjacent connection nodes 21, so that the two reactors are disconnected from each other.

[0036] In this way, the above-mentioned continuous flow synthesis equipment connects all the reactors through the transmission pipe network 20. When the process needs to be changed, there is no need to remove the pipeline. It is only necessary to control the corresponding connection node 21 so that the two connection nodes 21 connected to the two reactors can be connected to each other, and the two reactors can be connected to each other to transmit materials. If the two connection nodes 21 connected to the two reactors are disconnected from each other, the two reactors can be disconnected from each other and no interference is generated. In this way, when the continuous flow synthesis equipment needs to change the process, it is only necessary to control the connection and disconnection of the connection node 21 with other connection nodes 21, without the need to disassemble and install the pipeline again, which greatly reduces the cost of changing the process of the continuous flow synthesis equipment.

[0037] Optionally, the multiple reactors include a low-temperature reactor 10, an ultra-high temperature fixed bed reactor 11, and a PTFE high-temperature reactor 12. It should be noted that the reactors include but are not limited to reactors for chemical reactions, and may also include functional devices such as a liquid-liquid separator 13, which are not limited here.

[0038] In the embodiment of the present invention, each connection node 21 can be connected to any other connection node 21 through at least two paths. Each path between two connection nodes 21 represents that there is a pipeline between the two connection nodes 21 for connecting the two connection nodes 21. When two reactors are respectively connected to two connection nodes 21, there will be at least two pipelines for connecting the two reactors. In this way, when the pipeline for connecting the two reactors is blocked or damaged, the connection or disconnection between the connection node 21 and the adjacent connection node 21 can be controlled to stop the use of the faulty pipeline and enable another pipeline between the two reactors, thereby quickly solving the pipeline failure problem.

[0039] In some embodiments, in order to enable each connection node 21 to be connected to any other connection node 21 through at least two paths, the transmission pipeline network 20 includes a plurality of honeycomb units 22, the pipes in each honeycomb unit 22 are connected end to end, and all the honeycomb units 22 form a honeycomb structure. Each connection node 21 is located on one of the honeycomb units 22 and passes through the honeycomb structure. In this way, through the transmission pipeline network 20 with a honeycomb structure, there can be multiple paths between every two connection nodes 21 for connecting the two connection nodes 21 to each other.

[0040] For example, when two connection nodes 21 are located on the same honeycomb unit 22, one of the connection nodes 21 can be connected to the other connection node 21 in a clockwise manner or in a counterclockwise manner. When two connection nodes 21 are located on two adjacent honeycomb units 22, one of the connection nodes 21 can be directly connected to the other connection node 21 or indirectly connected to the other connection node 21 through other honeycomb units 22. In this way, through the honeycomb structure transmission pipe network 20, there are multiple options for the connection path of two adjacent connection nodes 21, which greatly improves the topology of the transmission pipe network 20 and is more conducive to solving the problem of pipeline failure.

[0041] Specifically in the embodiment, the transmission pipeline network 20 includes a plurality of adapters 23 and connecting pipes 24, all the adapters 23 and all the connecting pipes 24 are spliced ​​together to form a honeycomb structure, and each adapter 23 is provided with the above-mentioned connection node 21. In addition to being used to connect two adjacent connecting pipes 24 to each other, the adapter 23 can also be used to connect the connecting pipe 24 to the reactor.

[0042] Specifically in the embodiment, if the coverage area of ​​the transmission pipe network 20 is larger, the transmission pipe network 20 can be connected to more reactors to improve the reaction efficiency of the continuous flow synthesis equipment. To this end, the connecting pipes 24 of each honeycomb unit 22 are spliced ​​together to form a hexagon. In actual use, the hexagon is one of the three regular polygons that can cover a plane without overlapping, namely a hexagon, a square and a regular triangle, and among these regular polygons, the hexagon occupies the largest area with the smallest amount of material. Therefore, the transmission pipe network 20 adopts hexagonal honeycomb units 22, which can enable the transmission pipe network 20 to cover a sufficiently large area, thereby facilitating the transmission pipe network 20 to be connected to more reactors, thereby improving the reaction efficiency of the continuous flow synthesis equipment.

[0043] Furthermore, an adapter 23 is provided at the corner of each honeycomb unit 22 to change the angle of two adjacent connecting pipes 24 through the adapter 23 so that a certain angle is formed between the two connecting pipes 24. In this way, when multiple connecting pipes 24 are spliced ​​with each other through the adapter 23, the above-mentioned hexagon can be formed.

[0044] In the embodiment of the present invention, the continuous flow synthesis device further comprises a mounting base 30, and the mounting base 30 is used to mount the above-mentioned transmission pipe network 20 and the reactor. In order to make the overall appearance of the continuous flow synthesis device more beautiful, the transmission pipe network 20 is mounted on the bottom of the mounting base 30, and all the reactors are mounted on the top of the mounting base 30. While the overall appearance of the continuous flow synthesis device is more beautiful, the number of pipes exposed on the surface of the continuous flow synthesis device can also be reduced to reduce the corrosion of the pipes.

[0045] In order to enable the reactor installed on the top of the mounting seat 30 to be interconnected with the transmission pipe network 20 located at the bottom of the mounting seat 30, the continuous flow synthesis device also includes a plurality of connection joints (not marked) installed on the top of the mounting seat 30, and all the connection joints are connected to all the connection nodes 21 one by one, so that the connection nodes 21 of the transmission pipe network 20 are extended to the top of the mounting seat 30 through the connection joints. In this way, each reactor is connected to one or more of the connection joints, so that the reactor and the connection nodes 21 of the transmission pipe network 20 can be connected to each other, and the connection joints greatly facilitate the disassembly and assembly of the reactor and the transmission pipe network 20. Whether it is necessary to install a new reactor or dismantle the old reactor, it is only necessary to disassemble and assemble the reactor and the connection joints on the surface of the mounting seat 30, and the main part of the transmission pipe network 20 will not be involved, thereby reducing the steps of disassembly and assembly of the reactor.

[0046] In actual use, each reactor only needs to be connected to one or several connection nodes 21, that is, each reactor only needs to be connected to one or several connection joints, so the remaining connection joints will be idle. If left unattended, it may cause debris to enter the transmission pipeline 20 through the connection joints, or cause corrosion of the connection joints.

[0047] To this end, in some embodiments, the continuous flow synthesis device further includes a cover 32, which is mounted on the top of the mounting seat 30 and is used to seal at least one connection joint. In this way, for a connection joint in a restricted state, the cover 32 can be used to seal the connection joint to prevent external debris from entering the connection joint, and at the same time, the connection joint can be protected to reduce corrosion of the connection joint.

[0048] Specifically in the embodiment, the cover 32 can be used to seal the connection joint, and can also be used to seal the connection node 21 corresponding to the connection joint, so that the connection node 21 is disconnected from the adjacent connection node 21. Specifically, when the cover 32 is installed on the top of the mounting seat 30, the cover 32 will extend into the connection joint until the cover 32 extends into the adapter 23 corresponding to the connection node 21, and blocks the adapter 23, so that the adapter 23 cannot communicate with other connection pipes 24, so that the connection node 21 is disconnected from the adjacent connection node 21, and the connection node 21 is sealed.

[0049] In this way, when the operator needs to control the connection or closure between the connection node 21 and other connection nodes 21, the cover 32 can be used to close the connection joint corresponding to the connection node 21, and at the same time, the connection node 21 is disconnected from other connection nodes 21. The operator only needs to complete the connection or disconnection between each connection node 21 and the adjacent connection node 21 on the surface of the mounting seat 30, which greatly facilitates the operator to re-establish the connection pipeline 24 between the two reactors.

[0050] Specifically in the embodiment, the adapter 23 located between two adjacent honeycomb units 22 needs to be connected to three connecting pipes 24 at the same time, but in actual use, the three connecting pipes 24 may only need to be connected to two of them. If a sealing cover 32 is used, all three connecting pipes 24 will be closed, which is not suitable for the situation where two connecting pipes 24 are connected to each other.

[0051] To this end, the continuous flow synthesis device also includes a three-way valve 31, which is installed on the adapter 23 to controllably connect or disconnect any two of the three connecting pipes 24 connected to the adapter 23. In this way, the connection or closure of the three connecting pipes 24 is controlled by the three-way valve 31, which greatly increases the flexibility of the operator in setting the connecting pipes 24. At the same time, the flow of the three connecting pipes 24 can also be controlled by the three-way valve 31. For example, when two of the three connecting pipes 24 are used to input reactants and the other is used to output reactants, the flow of the two connecting pipes 24 for input can be controlled by the three-way valve 31 when they merge, thereby controlling the flow of the connecting pipe 24 for outputting reactants, thereby achieving the effect of adjusting the flow of the reactants input to the reactor.

[0052] In some embodiments, the transmission pipe network 20 can be used to establish a connection channel between two reactors, and can also be used to input external reactions into the reactor, or to output the reactants generated by the reactor from the continuous flow synthesis device. To this end, the continuous flow synthesis device also includes an inlet and outlet liquid joint 33, which is installed on the mounting seat 30 and is connected to the transmission pipe network 20, so that the reactants can be input into the transmission pipe network 20 through the inlet and outlet liquid joint 33, and finally input into the reactor. The reactants generated by the reactor can also be input into the inlet and outlet liquid joint 33 through the transmission pipe network 20, and finally output from the continuous flow synthesis device.

[0053] The above continuous flow synthesis equipment has at least the following advantages:

[0054] All reactors are connected by the transmission pipe network 20. When the process needs to be changed, there is no need to remove the pipeline. It is only necessary to control the corresponding connection node 21 so that the two connection nodes 21 connected to the two reactors can be connected to each other, and the two reactors can be connected to each other to transmit materials. If the two connection nodes 21 connected to the two reactors are disconnected from each other, the two reactors can be disconnected from each other and no longer interfere. In this way, when the continuous flow synthesis equipment needs to change the process, it is only necessary to control the connection and disconnection of the connection node 21 with other connection nodes 21, without the need to disassemble and install the pipeline again, which greatly reduces the cost of changing the process of the continuous flow synthesis equipment.

[0055] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0056] The above-mentioned embodiments only express several implementation methods of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A continuous flow synthesis device, characterized in that: The continuous flow synthesis equipment comprises: Multiple reactors; A transmission pipe network (20) comprises a plurality of interconnected connection nodes (21), and each of the connection nodes (21) can be controlled to be interconnected or disconnected with an adjacent connection node (21); Each of the reactors is connected to one or more of the connection nodes (21) so that any two of the reactors can be connected or disconnected with each other; Each of the connection nodes (21) can be connected to any other connection nodes (21) via at least two paths; The transmission pipe network (20) comprises a plurality of honeycomb units (22), the pipes in each of the honeycomb units (22) are connected end to end, the pipes of all the honeycomb units (22) are interconnected to form a honeycomb structure, and each of the connection nodes (21) is located on one of the honeycomb units (22).

2. The continuous flow synthesis device according to claim 1, characterized in that: The transmission pipe network (20) comprises a plurality of adapters (23) and a plurality of connecting pipes (24); all of the adapters (23) and all of the connecting pipes (24) are spliced ​​together to form the honeycomb structure; and each of the adapters (23) is provided with the connecting node (21).

3. The continuous flow synthesis device according to claim 2, characterized in that: The connecting pipes (24) of each honeycomb unit (22) are spliced ​​together to form a hexagon, and the adapter (23) is provided at the corner of each honeycomb unit (22).

4. The continuous flow synthesis device according to claim 3, characterized in that: The continuous flow synthesis device further comprises a three-way valve (31), which is installed on the adapter (23) so as to controllably connect or disconnect any two of the three connecting pipes (24) connected to the adapter (23).

5. The continuous flow synthesis device according to claim 1, characterized in that: The continuous flow synthesis device further comprises a mounting seat (30), the bottom of which is mounted the transmission pipe network (20), and the top of which is mounted all the reactors; Wherein, the continuous flow synthesis equipment also includes a plurality of connection joints installed on the top of the mounting seat (30), all of the connection joints are connected to all of the connection nodes (21) in a one-to-one correspondence, and each of the reactors is connected to one or more of the connection joints.

6. The continuous flow synthesis device according to claim 5, characterized in that: The continuous flow synthesis device also includes a cover (32), which is installed on the top of the mounting seat (30) and is used to close at least one of the connecting joints.

7. The continuous flow synthesis device according to claim 6, characterized in that: When the connection joint is closed by the cover (32), the cover (32) extends into the connection joint and closes the connection node (21) corresponding to the connection joint, so that the connection node (21) is disconnected from the adjacent connection node (21).

8. The continuous flow synthesis device according to claim 6, characterized in that: The continuous flow synthesis device also includes an inlet and outlet liquid joint (33), which is installed on the mounting seat (30) and is connected to the transmission pipe network (20).

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