A kind of Zhuang medicine skin-saving spray and preparation method thereof

Abstract

The present invention relates to the technical field of traditional Chinese medicine, specifically a Zhuang medicine skin-saving spray and a preparation method thereof. This application uses four Zhuang medicines and Chinese medicines such as Jiubiying, Puhuang, Zhangjiefeng, and Licorice to form a skin-saving prescription. In the prescription, Jiubiying is the main medicine, clearing away heat and detoxifying, reducing swelling and relieving pain, and stopping bleeding and promoting tissue regeneration; Zhangjiefeng is the minister medicine to strengthen the function of clearing heat and detoxifying, and has the function of sterilization; Puhuang is used to cool blood, promote blood circulation, remove blood stasis and relieve pain, and Licorice is used to detoxify and reconcile various medicines, so that various medicines are combined to take effect, and the effect is significantly enhanced than that of each medicine used alone, and the technical effect that the existing Chinese medicine external preparations for treating radiation dermatitis do not have is achieved, and the effect is more obvious when used to treat radiation dermatitis. The Zhuang medicine skin-saving spray of this application has a strong wound adsorption capacity, which can effectively clear away heat and detoxify, promote dampness and relieve stranguria, remove blood stasis and dredge collaterals, cool blood and promote blood circulation, eliminate spots, relieve pain, etc., can prevent radiation dermatitis infection and promote wound healing, and can effectively shorten the wound healing time and reduce the formation of scars.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a Zhuang medicine skin-saving spray and a preparation method thereof. Background Art

[0002] Radiotherapy is part of the comprehensive sequential treatment of most malignant tumors. With the widespread clinical practice of radiotherapy, the various complications caused by this therapy have been paid attention to by the medical community. Radiotherapy is one of the commonly used methods for treating head and neck tumors, and has a significant effect on controlling local tumor lesions and preventing tumor metastasis.

[0003] The ideal goal of radiotherapy is to minimize the ionizing radiation damage to normal tissues and enhance the sensitivity of tumor tissues to radiation-induced cell killing. In order to achieve the therapeutic effect of radical cure of malignant tumors, it is often necessary to increase the radiation dose of radiotherapy, which may cause damage to adjacent tissues and organs. The skin of the head and neck is weak. Radiotherapy will cause damage to the normal tissues around the irradiated target area, which is easy to cause acute radiation dermatitis. The clinical manifestations are mainly local skin itching, erythema, ulceration and other symptoms, which seriously affect the treatment effect and quality of life of patients. The mechanism may be that radiation can destroy the mitosis of basal cells. When the growth and migration rate of basal cells is lower than the rate of repair required for epidermal shedding, visible skin damage will occur, leading to inflammation; in addition, capillaries are prone to fibrosis after irradiation, affecting blood circulation, which leads to the persistence of edema; a large amount of radiation destroys the primitive cells of hair follicles and sweat glands, affecting the secretion function of sweat glands and sebaceous glands, leading to dry peeling and hair loss. If radiotherapy is not stopped at this time, a large number of blisters will form on the skin. After the blisters fall off, wet peeling will form, and then ulcers will appear.

[0004] Severe radiation dermatitis rapidly necrotizes tissues after erythema and edema, and then forms stubborn ulcers. The depth of the ulcer varies, and it can usually penetrate the skin, muscles, and even bone tissue. There are dirty yellow-white necrotic tissue blocks on the bottom of the ulcer. The patient feels severe pain. It is difficult to heal, and after healing, atrophic scars, pigmentation, depigmentation, and capillary dilation will form. In severe cases, large blood vessels will be occluded, and dry gangrene will occur in the limbs. Ulcers and scars may develop cancer. Moreover, when scars grow beyond a certain limit, various complications will occur, such as destruction of appearance and functional activity disorders, which will bring great physical and mental pain to patients.

[0005] At present, Western medicine mainly uses topical hormone plasters, oral antihistamines, hormones, antibacterial drugs and other symptomatic treatments to treat radiation dermatitis. Western medicine has a single target, and long-term use is prone to drug resistance and reduced efficacy, and it is expensive. Compared with Western medicine, Chinese medicine has the advantage of multiple targets, which highlights its advantages in the treatment of radiation dermatitis. Traditional Chinese medicine believes that radiation dermatitis belongs to the fire evil among the six external evils, and the lesion site is on the skin. The treatment should focus on clearing heat and detoxifying, cooling blood and relieving pain. Zhuang medicine believes that "toxic deficiency causes disease" is the etiology and pathogenesis of skin diseases. The skin is closely related to the dragon path and the fire path. Zhuang medicine external treatment method clears the airway, valley path, water channel, regulates the dragon path and the fire path, regulates qi and blood, enhances the body's disease resistance, accelerates the dissolution or excretion of evil toxins, and restores the synchronization of the three qi to achieve the treatment purpose. Guangxi is rich in cold Chinese medicine and Zhuang medicine, which have outstanding effects in clearing heat and detoxifying and low cost. We should vigorously develop the treatment and use of Chinese medicine and ethnic medicine.

[0006] At present, traditional Chinese medicine for external use in the treatment of radiation dermatitis is one of the main research directions. However, the current traditional Chinese medicine for external use in the treatment of radiation dermatitis also has the disadvantages of multiple medicinal flavors, high cost, complicated ingredients that make it impossible to clarify the mechanism, mainly decoction, inconvenient to use, etc. Moreover, the current traditional Chinese medicine for external use in the treatment of radiation dermatitis cannot effectively reduce the formation of scars.

[0007] For example, patent CN201110451899.5 (medicine for treating radiation dermatitis after head and neck radiotherapy) specifically discloses that the medicine is made of the following components: 12 grams of rhubarb, 16 grams of astragalus, 12 grams of safflower, 18 grams of moutan bark, 15 grams of lithospermum, 10 grams of notoginseng, 15 grams of sanguisorba officinalis, 15 grams of pollen, 18 grams of lobelia, and 20 grams of frankincense; the above components are mixed and evenly crushed into 100 mesh fine powder, mixed evenly, and vaseline is added to make an ointment. It can only restore skin lesions and reduce edema, but cannot reduce the formation of radiation dermatitis scars.

[0008] For example, patent CN201911229156.6 (an external application Chinese medicine for treating radiation dermatitis and its preparation method) is an external application Chinese medicine for treating radiation dermatitis, which is prepared from the following components by weight: 0.5-1.5 parts of Panax notoginseng powder, 8-10 parts of Nepeta charcoal, 10-14 parts of Rubia charcoal, 13-18 parts of Platycladus orientalis charcoal, 10-14 parts of Lotus Root charcoal, and 3-8 parts of Bletilla striata. It can reduce wound secretions and relieve pain, but it also fails to reduce the formation of radiation dermatitis scars.

[0009] For example, patent CN201410050959.6 (a drug for radiation dermatitis and its preparation method), the drug is made of the following weight ratio of Chinese medicine raw materials: 11-19 parts of forsythia, 6-14 parts of andrographis, 11-19 parts of senecio, 11-19 parts of sophora flavescens, 11-19 parts of physalis, 11-19 parts of four tiles, 11-19 parts of tobacco leaves, 6-14 parts of duckweed, 6-14 parts of cnidium monnieri, 6-14 parts of phellodendron, 11-19 parts of scutellaria baicalensis, 15-25 parts of salvia miltiorrhiza, 11-19 parts of moutan bark, 11-19 parts of red peony root, 3-9 parts of leech, 20-40 parts of codonopsis pilosula, 1-3 parts of menthol. Its effect is that the inflammation of the wound surface subsides, the exudate is reduced, the fresh granulation tissue grows, and the ulcer is scabby, but it does not have the effect of reducing the formation of radiation dermatitis scars.

[0010] For example, patent CN201510679647.6 (a Chinese medicine composition for external use for preventing and treating radiation dermatitis and its preparation method) is made of raw materials in the following weight ratio: 15-25 parts of coptis root, 12-18 parts of phellodendron, 8-12 parts of dianthus, and 2-4 parts of catechu. It is mainly aimed at local skin lesion edema, and can better relieve the symptoms of radiation field skin pain and local skin lesion edema, but it does not mention the relevant content of reducing the formation of radiation dermatitis scars.

[0011] Therefore, the current research focus is to find a Chinese herbal external preparation for the treatment of radiation dermatitis that can prevent radiation dermatitis infection and promote wound healing, effectively shorten wound healing time, and reduce scar formation. Summary of the invention

[0012] In order to solve the above technical problems existing in the prior art, the present invention provides a Zhuang medicine skin-saving spray and a preparation method thereof. Specifically, it is achieved through the following technical solutions:

[0013] A strong medicine skin-saving spray contains the following raw materials: Jiubiying, Typha lachryma-curcuma, Sarcandra chinensis and liquorice.

[0014] Further, the extracts of schisandra chinensis, pollen cattail, Chinese knotweed and liquorice are extracts of schisandra chinensis, pollen cattail, Chinese knotweed and liquorice. Further, the extracts of schisandra chinensis, pollen cattail, Chinese knotweed and liquorice are water extracts of schisandra chinensis, pollen cattail, Chinese knotweed and liquorice.

[0015] Furthermore, the weight ratio of the herb, pollen, sarcandra and liquorice is as follows: 15 parts of herb, 6 parts of pollen, 6 parts of pollen and 5 parts of liquorice.

[0016] The preparation method of the Zhuang medicine skin-saving spray comprises the following steps:

[0017] (1) Take Jiu Bing Ying, Pu Huang, Zhong Jie Feng, and Licorice in proportion and set aside;

[0018] (2) Mix all the raw materials and boil them in water twice;

[0019] (3) Combine the decoctions, concentrate, filter, sterilize, and package.

[0020] Furthermore, the water decoction is to mix the four raw materials, add water and boil twice, add 10 times the weight of the medicine water for the first time, boil for 45 minutes, and add 6 times the weight of the medicine water for the second time, boil for 30 minutes; combine the decoctions, filter, concentrate the filtrate at 60°C to a clear paste with a density of 0.96-1.00, sterilize at 120°C, and package.

[0021] The method for preparing the Zhuang medicine skin-saving spray according to claim 5 is characterized in that the concentrated liquid medicine has 0.96g-1.00g of raw medicinal material per milliliter of liquid medicine

[0022] The Zhuangyao Jiufu spray is used as / in the preparation of radiation dermatitis drugs. Further, the radiation dermatitis drug is a drug that reduces the formation of radiation dermatitis scars.

[0023] Functions and indications: The Zhuang medicine skin-saving spray of the present application mainly has the functions of clearing away heat and detoxifying, removing blood stasis and promoting tissue regeneration, etc.; it is used to prevent and treat radiation-induced skin and mucous membrane damage, with symptoms such as dryness, itching, redness, swelling, and ulceration of the skin and mucous membranes, and is also suitable for patients with skin diseases with the above symptoms.

[0024] Prescription theory: Treat radiation skin and mucous membrane damage caused by heat toxicity, symptoms include dryness, itching, redness, swelling, ulceration, etc. of the skin and mucous membranes, and it is also suitable for skin diseases with the above symptoms. In this application, Jiubiying is the main drug to clear away heat and detoxify, reduce swelling and relieve pain, stop bleeding and promote tissue regeneration, and Zhongjiefeng is the minister drug to strengthen the function of clearing heat and detoxifying, and also has the function of sterilization, and Puhuang is used to cool blood, promote blood circulation, remove blood stasis and relieve pain, and Licorice is used to detoxify and harmonize the drugs.

[0025] Spray refers to a dosage form in which the drug raw material or suitable excipients are filled in a special device, and the contents are sprayed in a mist form by the pressure of a manual pump when used. According to the composition of the contents, sprays can be divided into solution type, emulsion type and suspension type. Sprays have the following advantages: ① Sprays have no propellant, do not require special pressure-resistant containers, and have low production technology and cost requirements; ② It is relatively convenient to use and carry; ③ Some nasal inhalable sprays have the effect of targeted drug delivery, and the small molecule drugs in them can pass through the blood-brain barrier through the nasal cavity and have miraculous effects in the treatment of neurological diseases; ④ Compared with oral drugs, it can effectively avoid the first-pass effect of the liver. Head and neck radiation therapy often causes skin damage to the neck, mouth, throat, etc. The development of a skin-saving spray can be conveniently used in the above treatment areas, with precise efficacy and low price. Zhuangyao skin-saving spray not only relies on the efficacy of the drug, but also relies on the advantages of the spray formulation and its coolness to have a targeted effect on the "heat" reflected by radiation dermatitis. In order to reduce the use of western medicine, lower treatment costs, and reduce drug resistance, it is worthwhile to vigorously develop the clinical use of Zhuang medicine and Chinese medicine sprays to make outstanding contributions to head and neck radiotherapy.

[0026] Compared with the prior art, the technical effects created by the present invention are embodied in:

[0027] This application combines four Zhuang medicines and Chinese medicines such as Jiubiying, Puhuang, Zhangjiefeng, and Licorice to form a skin-saving prescription. Jiubiying is the main medicine in the prescription, which can clear away heat and detoxify, reduce swelling and relieve pain, and stop bleeding and promote tissue regeneration; Zhangjiefeng is the ministerial medicine to strengthen the function of clearing heat and detoxifying, and also has the function of sterilization; Puhuang is used to cool blood, promote blood circulation, remove blood stasis and relieve pain, and Licorice is used to detoxify and reconcile all the medicines, so that all the medicines work together, and the effect is significantly enhanced than the effect of each medicine used alone, and the technical effect that the existing Chinese medicine external preparations for treating radiation dermatitis do not have is achieved, and the effect is more obvious when used to treat radiation dermatitis. The Zhuang medicine skin-saving spray of this application has a strong wound adsorption capacity, and its unique Zhuang medicine and Chinese medicine combination can effectively clear away heat and detoxify, promote dampness and relieve stranguria, remove blood stasis and dredge collaterals, cool blood and promote blood circulation, eliminate spots, relieve pain, etc., which can prevent radiation dermatitis infection and promote wound healing. It can effectively shorten the wound healing time and reduce the formation of scars. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 Yes: After Ms. Huang's left thigh myxofibrosarcoma was resected, she had no contraindications to radiotherapy. She used intensity-modulated radiotherapy to treat the tumor area in her left thigh. The skin was damaged after one month of radiotherapy at a conventional dose. At this time, the patient's skin was red and edematous, with patchy wet peeling and partial scabs.

[0029] Figure 2 Yes: In Figure 1 Continue to use the skin-saving agent to spray the wound 4-5 times a day. After one week of spraying, the wound will heal. At this time, the patient's skin has no redness or edema, and the skin lesions are drier than before.

[0030] Figure 3 Yes: In Figure 2 In the case of continued use of skin rescue agent spray wound 4-5 times a day, spray a week later, the healing situation. At this time, the patient's skin lesions are reduced and the scabs fall off.

[0031] Figure 4 Yes: In Figure 3 Continue to use the skin-saving agent to spray the wound 4-5 times a day. After 10 days of spraying, the healing situation will be improved. At this time, the scabs of the patient are basically removed, the surrounding pigmentation is deposited, and the deep skin lesions are gradually healed. DETAILED DESCRIPTION

[0032] The technical solution of the present invention is further defined below in conjunction with specific implementation methods, but the scope of protection required is not limited to the description.

[0033] Example 1

[0034] The Zhuangyao skin-saving spray is prepared by the following steps:

[0035] (1) Take 15g of Jiu Bing Ying, 6g of Radix Aconiti Lateralis Preparata, 6g of Typhae Pollen, and 5g of Licorice for later use;

[0036] (2) Mix all the raw materials and boil them in water twice;

[0037] (3) Combine the decoctions, concentrate, filter, sterilize, and package according to (specification: 100 ml per bottle (each ml of the decoction is equivalent to 0.96 g of the decoction piece)).

[0038] Case 1:

[0039] Zhong Moumou, female, 52 years old, was admitted to our hospital on August 6, 2020. The patient was hospitalized in our hospital on November 27, 2019 due to a right breast mass. On November 29, 2019, she underwent right breast mass resection + right breast cancer modified radical mastectomy + left subclavian vein infusion port implantation under general anesthesia. The operation went smoothly and she recovered well after the operation. Routine postoperative pathology showed (right breast mass> non-special type invasive cancer. The patient was discharged after recovery. From 2019-12-14 to 2020-02-29, four cycles of postoperative chemotherapy AC regimen were performed in our department. After chemotherapy, the patient's local symptoms were slightly improved compared with before. On 2020-05-11, 2020-06-01, and 2020-06-22, the 8th, 9th, and 10th cycles of TCb regimen were performed. Later, the patient considered local recurrence of the right chest wall. On July 20, the patient underwent radiotherapy for right chest wall metastasis in our department and was discharged after completing the first stage of radiotherapy (12 times). In order to continue radiotherapy, the patient came to our outpatient clinic for treatment, and the outpatient clinic planned to be admitted to our department for "breast cancer".

[0040] After 5 weeks of radiotherapy, 50GY / 25f treatment was completed. The local skin of the chest wall and neck radiotherapy was bright red erythema, wet peeling, and obvious edema. The skin rescue agent was sprayed on the affected area 4-5 times a day. After 1 week of use, the patient's erythema became lighter, dry peeling, and edema subsided. After 3 days of continued use, the patient did not see obvious peeling, the erythema further subsided, and there was occasional itching.

[0041] Case 2:

[0042] Guo Moumou, male, 72 years old, was admitted to the hospital from the outpatient department of "Internal Oncology" at 10:02 on August 14, 2020 with the main complaint of "discovering a neck tumor for more than one month". Admission symptoms: right neck tumor, no fever and chills, no cough and sputum, no tinnitus, hearing loss, no hoarseness, no dizziness and headache, no chest tightness and shortness of breath, normal bowel movements, good appetite and sleep, and a weight loss of 5kg in the past six months.

[0043] The patient underwent intensity modulated radiotherapy. When the radiation dose reached 56Gy / 28f, the patient's local skin in the radiotherapy area had severe wet peeling, large-scale fusion, and pitting edema. The radiotherapy was suspended, and the wound was sprayed with skin-saving agent 4-5 times a day. On the 5th day of medication, the patient's skin was observed and found that the skin lesions were drier and the edema was reduced; on the 10th day of medication, the skin lesions were scabby and the edema subsided; on the 15th day of medication, new granulation tissue grew, the scabs of the skin lesions were removed, and local pigmentation was deposited. Radiotherapy was continued until the end of the course of treatment.

[0044] Case 3:

[0045] Patient Li, male, 86 years old, was admitted to the hospital at 10:50 on August 10, 2020, with the main complaint of "diagnosed with skin cancer in May and found a lump in the armpit for more than 3 months". Admission symptoms: ruptured and exuded from the right axillary mass, red and swollen skin near the mass, local pus discharge, no pain, no fever, good appetite and sleep, and normal bowel movements. On August 18, 2020, the patient was diagnosed with squamous cell carcinoma of the skin of the anterior upper chest wall and metastasis to the right axillary and right supraclavicular lymph nodes, with no contraindications to radiotherapy. Emphasized radiotherapy technology was used, with 9 conformal fields, the prescription dose of the anterior upper chest wall was PGTV 3000cGy / 15f, the prescription dose of the right axillary lymph node metastasis was PGTVnd7000cGy / 35f, and the prescription dose of the right supraclavicular lymph node metastasis was GTVnd-neck 7000cGy / 35f.

[0046] After 3 weeks of radiotherapy, the patient developed dry peeling and redness on the local skin of the right supraclavicular area (grade I reaction); the local skin of the right subaxillary area developed bright red erythema and patchy wet peeling (grade II reaction). The patient was still tolerable and continued chemotherapy. In the 5th week of radiotherapy, the redness of the local skin of the patient's right supraclavicular area further worsened, showing patchy wet peeling and obvious tenderness (grade II reaction); the local skin of the right subaxillary area developed severe wet peeling and large-scale fusion (grade III reaction). While adhering to the chemotherapy regimen, the skin rescue agent was used in conjunction with the use of the skin lesion, spraying the skin lesion 4-5 times a day. After 1 week of medication, the patient's skin lesions did not deteriorate further. After 2 weeks of medication, the patient's right supraclavicular skin lesions turned from grade II to grade I; the right subaxillary skin lesions turned from grade III to grade II.

[0047] Case 4:

[0048] Zhou, male, 36 years old, was admitted to the hospital at 09:04 on December 31, 2020 with the main complaint of "diagnosed with nasopharyngeal carcinoma for more than 1 year". The patient was diagnosed with undifferentiated non-keratinizing nasopharyngeal carcinoma with clear multiple lymph node metastases. The nasopharyngeal tumor was in the local advanced stage with a poor prognosis. The treatment was nasopharyngeal radiotherapy with concurrent chemotherapy. Radiotherapy for nasopharyngeal carcinoma began on November 16, 2020. During radiotherapy, the patient had low immunity and was given quinidine to improve immunity. Entecavir antiviral treatment was continued. During the treatment, the patient still had obvious pharyngeal pain, poor appetite, and several ulcers were visible in the mouth and after the pharynx. Radiotherapy oropharyngeal mucosal reaction, radiation oral mucositis, and radiation pharyngitis were considered.

[0049] When the patient's radiation dose reached 20Gy, the oral mucosa became red and swollen, with scattered erythema and pain. The patient was given a skin-saving agent to gargle for 5 minutes, 3 times a day. Radiotherapy continued, and the patient insisted on gargling. The oral mucosa was red and swollen, with scattered erythema that had not merged. The mild pain was tolerable and was maintained until the end of radiotherapy, 7040Cgy / 32f. After the end of radiotherapy, the patient continued to gargle. The erythema disappeared after 5 days, and the mucosa returned to normal after 8 days, with no redness or swelling.

[0050] Case 5: Huang Moumou, female, 48 years old, was admitted to the hospital from the outpatient department at 14:40 on March 3, 2020 with "sarcoma" as the main complaint of "diagnosed with myxofibrosarcoma of the left thigh for more than one year". The patient is a middle-aged female with chronic onset. In June 2018, a lump was found after accidentally colliding with the left thigh. At that time, it was not taken seriously. The lump has not subsided and no systematic treatment was given. On June 28, 2019, an obvious lump in the left thigh was found. An extended excision biopsy of the left thigh tumor was performed at the local Municipal People's Hospital. On July 4, the intraoperative pathology showed: (left thigh tumor) malignant peripheral nerve sheath tumor. After the operation, anti-inflammatory, analgesic, fluid infusion and other treatments were given and the patient was discharged from the hospital. On August 8, 2019, he was hospitalized in the Affiliated Tumor Hospital of Guangxi Medical University due to the recurrence of the left thigh tumor. On August 16, 2019, he underwent an extended resection of the myxofibrosarcoma on the outside of the left thigh root. Postoperative pathology: It was consistent with high-grade myxofibrosarcoma. He was discharged from the hospital in a stable condition. On November 6, 2019, he was hospitalized in the Affiliated Tumor Hospital of Guangxi Medical University to exclude chemotherapy contraindications and received chemotherapy (ifosfamide + pirarubicin) for 3 cycles. The process went smoothly. On January 9, 2020, he began to take anlotinib targeted therapy until now. During this hospitalization, the patient had symptoms of clear mind, weak spirit, general fatigue, occasional cough, no sputum cough, chest tightness and other discomfort. After postoperative anti-infection, immune enhancement, traditional Chinese medicine and other treatments, the blood biochemistry was rechecked on March 27 without obvious disease progression. The patient was generally in good condition upon admission, and radiotherapy was given to the surgical area of ​​the left thigh tumor, with 9 conformal fields and a prescription dose of 6000cGy / 30f. Skin damage after 1 month of radiotherapy according to the prescribed dose is shown in Figure 1 (The photo is dated 5.25). The skin-saving agent of Example 1 was sprayed on the wound 4-5 times a day. After one week of spraying, the wound healed. Figure 2 (The photo is dated 6.1). Continue to use the skin-saving agent of Example 1 to spray the wound 4-5 times a day. After one week of spraying, the healing condition is Figure 3 (The photo is dated 6.8.) Continue to use the skin-saving agent of Example 1 to spray the wound 4-5 times a day. After 10 days of spraying, the healing condition is Figure 4 (The photo date is 6.18).

[0051] Treatment Experiments:

[0052] According to the RTOG grading standard, 60 patients with grade III dermatitis were selected and randomly divided into two groups: a treatment group and a control group with 30 people in each group. The control group used "Bactroban Ointment" to apply to the lesions 3 times a day; the treatment group used a skin-saving agent to spray the lesions 4-5 times a day on the basis of the control group. After 2 weeks of use, the changes in the patients' skin lesions were observed. The efficacy was divided into three levels: cured, effective, and ineffective. Cured: The dermatitis grade was reduced to grade 0; effective: the dermatitis area was reduced, the degree was alleviated, and the dermatitis grade was reduced; ineffective: the dermatitis area did not shrink and the degree did not improve. Comparison of clinical efficacy between the two groups: See Table 1. The total effective rate of the treatment group was 100%, which was higher than 90% of the control group (p<0.05). It shows that the therapeutic effect of this application on radiation dermatitis is significantly better than the existing drug "Bactroban Ointment".

[0053] Table 1 Comparison of clinical efficacy between the two groups

[0054]

[0055] Preventive treatment trials:

[0056] 60 patients who were about to undergo radiotherapy were selected and randomly divided into two groups: 30 people in the treatment group and 30 people in the control group. The control group used "Bactroban Ointment" to be applied to the lesions 3 times a day; the treatment group used a skin-saving agent to spray the lesions 4-5 times a day on the basis of the control group. The experiment started from radiotherapy until the cumulative radiation dose of each patient reached 7040cGy. The degree of skin lesions of the patients was counted to infer the preventive efficacy of the skin-saving agent. According to the RTOG grading standard, in the treatment group, there were 15 people at grade I, 15 people at grade II, 0 people at grade III, and 0 people at grade IV. In the control group, there were 8 people at grade I, 20 people at grade II, 2 people at grade III, and 0 people at grade IV. The comparison of the preventive efficacy of the two groups is shown in Table 2. There is a significant difference in the preventive efficacy of the two groups (p<0.05), and the preventive efficacy of the treatment group is higher than that of the control group. It shows that the preventive effect of this application on radiation dermatitis is significantly better than the existing drug "Bactroban Ointment".

[0057] Table 2 Comparison of preventive efficacy

[0058]

[0059] Finally, it should be pointed out that the above embodiments are only representative examples of the present invention. Obviously, the technical solution of the present invention is not limited to the above embodiments, and there are many variations. All variations that can be directly derived or associated with the content disclosed by ordinary technicians in this field should be considered as the protection scope of the present invention.

Claims

1. A skin-saving spray, characterized in that: The drug is prepared from the following raw materials: 15 parts of Jiubiying, 6 parts of Sarcandra chinensis, 6 parts of Typha acuminatum and 5 parts of Licorice.

2. The Zhuang medicine skin-saving spray according to claim 1, characterized in that: The scutellaria baicalensis, pollen cattail, sarcandra chinensis and liquorice are extracts of scutellaria baicalensis, pollen cattail, sarcandra chinensis and liquorice.

3. The strong medicine skin-saving spray according to claim 2, characterized in that: The extracts of Herba Polygoni Multiflori, Pollen Typhae, Radix Sarcandrae and Radix Glycyrrhizae are water extracts of Herba Polygoni Multiflori, Pollen Typhae, Radix Sarcandrae and Radix Glycyrrhizae.

4. The method for preparing the Zhuang medicine skin-saving spray according to any one of claims 1 to 3, characterized in that: The following steps are involved: (1) Take Jiu Bing Ying, Pu Huang, Zhong Jie Feng, and Licorice in proportion and set aside; (2) Mix all the raw materials and boil them in water twice; (3) Combine the decoctions, concentrate, filter, sterilize, and package.

5. The method for preparing the Zhuang medicine skin-saving spray according to claim 4, characterized in that: The decoction comprises the following steps: mixing the four raw materials, adding water and boiling for two times, adding water 10 times the weight of the medicine for the first time and boiling for 45 minutes, and adding water 6 times the weight of the medicine for the second time and boiling for 30 minutes; combining the decoctions, filtering, concentrating the filtrate at 60° C. to a clear paste with a density of 0.96-1.00, sterilizing at 120° C., and packaging.

6. The method for preparing the Zhuang medicine skin-saving spray according to claim 4, characterized in that: The concentrated medicinal solution contains 0.96 g to 1.00 g of the raw medicinal material per milliliter of the medicinal solution.

7. Use of the Zhuang medicine skin-saving spray according to any one of claims 1 to 3 in the preparation of radiation dermatitis drugs.

8. The use of the Zhuang medicine skin-saving spray according to claim 7, characterized in that: The radiation dermatitis drug is a drug that reduces the formation of radiation dermatitis scars.

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