A seed treatment agent containing pentocyclanil and clothianidin and application thereof

Abstract

The present invention provides a seed treatment agent containing pentocyclanil and clothianidin, which contains the following active ingredients in percentage by weight: pentocyclanil 0.2-10%, azoxystrobin or fludioxonil 1-8%, and clothianidin 5-30%. The seed treatment agent is used for crop seed treatment, can achieve simultaneous prevention and control of crop diseases and insect pests, has a significant promoting effect, can significantly reduce the dosage of active ingredients, and slow down the generation of drug resistance of diseases and insect pests.

Description

Technical Field

[0001] The invention relates to the technical field of pesticides, in particular to a seed treatment agent comprising penflufenacil and clothianidin and application thereof. Background Art

[0002] Seed treatment agent is a pesticide preparation with film-forming properties used for treating crop or other plant seeds. Common seed treatment agents are made from pesticide originals (insecticides, fungicides, hormones and seed fertilizers, etc.), film-forming agents, wetting agents, dispersants, penetrants and other additives. They can be coated directly or after dilution on the surface of seeds to form a water-based suspension preparation with a protective film of certain strength and permeability. There are no reports in the prior art on the use of fluopicolide, azoxystrobin or fludioxonil and clothianidin for crop seed treatment.

[0003] Fluopicolide is a new type of pyrazole amide fungicide developed in recent years, which has protective, therapeutic, systemic and transporting effects. The fungicide is a succinate dehydrogenase (SDH) inhibitor, which mainly acts on the electron transfer complex II of the respiratory chain to block energy metabolism. It can prevent and control seed-borne and soil-borne basidiomycete and ascomycete diseases, mainly potato black mole, wheat sheath blight, rice sheath blight caused by Rhizoctonia solani, wheat loose smut, wheat bunt, corn leaf spot, etc. The treated seeds can absorb fluopicolide during the germination process and transmit it to other parts of the plant body through the xylem, thus protecting the crops.

[0004] Azoxystrobin is a new type of highly effective methoxyacrylate fungicide with protective, therapeutic, eradication, penetration and systemic activities. It destroys the energy synthesis of pathogens by inhibiting their respiration, thus making them lose their vitality. Azoxystrobin has a broad-spectrum fungicidal activity and has good fungicidal activity against almost all fungal diseases (Ascomycetes, Basidiomycetes, Oomycetes and Deuteromycetes) such as powdery mildew, rust, black spot, web spot, downy mildew, rice blast and dozens of other diseases. It is suitable for a variety of crops such as cereals, vegetables, rice, fruit trees, etc., and has good crop safety and very outstanding environmental compatibility.

[0005] Fludioxonil is a broad-spectrum contact fungicide. It is used as a foliar fungicide to control damping-off pathogens such as Solanum solani. It is particularly effective against gray mold. When used as a seed treatment agent, it can control most seed-borne and soil-borne fungal diseases. It is stable in the soil and forms a protective zone around the roots of seeds and seedlings to prevent the invasion of pathogens. It has a novel structure and is not prone to cross-resistance with other fungicides.

[0006] Clothianidin belongs to the neonicotinoid insecticide, which is a new type of highly efficient, safe and highly selective insecticide. Clothianidin mainly acts on nicotinic acetylcholine receptors (nAChR) and is an agonist of nAChR. It can selectively inhibit nAChR in the insect nervous system, making it impossible for ACh to bind to AChR, thereby blocking the normal conduction of signals in the insect central nervous system, causing insect paralysis and death. It has contact, stomach poison and systemic activity. It is mainly used to control aphids, leafhoppers, thrips, planthoppers and other Hemiptera, Coleoptera, Diptera and some Lepidoptera pests on rice, vegetables, fruit trees and other crops, and has high efficiency and broad spectrum characteristics.

[0007] The applicant has found that the combination of clothianidin and a compound fungicide (flutrifloxystrobin and myclobutanil / fludioxonil) can significantly enhance the insecticidal or fungicidal effect, has a significant promoting effect, can significantly reduce the dosage of active ingredients, and slow down the occurrence of drug resistance in pests and diseases. At the same time, the combination of insecticides and fungicides also has the effect of facilitating medication. Summary of the invention

[0008] The object of the present invention is to provide a seed treatment agent comprising penflufenacil and clothianidin and its application. The specific technical scheme is as follows:

[0009] A seed treatment agent containing pentocyclanil and clothianidin comprises the following active ingredients in percentage by weight: 0.2-10% of pentocyclanil, 1-8% of azoxystrobin or fludioxonil, and 5-30% of clothianidin.

[0010] Preferably, in the seed treatment agent of the present invention, pentafluoroacetic acid 0.5-5%, azoxystrobin or fludioxonil 1-6%, and clothianidin 10-20%.

[0011] Preferably, in the seed treatment agent of the present invention, penflufenacil accounts for 1%, azoxystrobin accounts for 4%, and clothianidin accounts for 19%.

[0012] The seed treatment agent of the present invention contains 1% of fludioxonil, 2% of fludioxonil and 19% of clothianidin.

[0013] The seed treatment agent of the present invention also contains an auxiliary ingredient acceptable to pesticides. It can be prepared into an adapted preparation; preferably, the preparation is a seed treatment suspension, a seed treatment emulsion, a seed treatment liquid, a solid seed treatment dispersible powder, a seed treatment dry powder, and a seed treatment soluble powder. Preferably, the auxiliary materials in the seed treatment agent are selected from: a wetting agent, a dispersant, a film former, a colorant, a thickener, an antifreeze agent, a preservative, a defoaming agent, an emulsifier, water, a filler, and an organic solvent, or a combination thereof. The above auxiliary materials are all common auxiliary materials in the art. A particularly preferred preparation is a seed treatment suspension.

[0014] The wetting agent and dispersant are preferably one or more of fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, polyoxyethylene fatty acid, alkyl aryl polyethylene glycol ether, alkyl sulfonate, aryl sulfonate, fatty acid polyethylene glycol, dodecylbenzene sulfonate, polyoxyethylene phenol formaldehyde condensate, naphthalene or alkylnaphthalene formaldehyde condensate sulfonate, fatty alcohol polyoxyethylene ether sulfonate, alkylphenol polyoxyethylene ether sulfonate, lignin and its derivative sulfonate, alkylphenol polyoxyethylene ether phosphate, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, and pull-opening powder.

[0015] In order to ensure that limited pesticide components are concentrated on seeds and roots, not easy to fall off and scatter, and reduce the spread of pesticides in the environment and contact with non-targets, the suspended seed treatment agent also needs to include a film-forming agent. The film-forming agent must ensure that the film has good air permeability and water permeability, and the seeds germinate and grow normally, and must also ensure that the film is insoluble in water, and the active ingredients in the film can be slowly released and have a long lasting effect. According to the present invention, the film-forming agent is preferably one or more of methyl cellulose, ethyl cellulose, sodium carboxymethyl cellulose, hydroxypropyl cellulose, sodium alginate, polyvinyl alcohol, polyethylene glycol, polyvinyl pyrrolidone, polyacrylamide, and sodium polyacrylate.

[0016] The colorant, also known as the warning colorant, can improve the safety of the use of the suspended seed treatment agent. The colorant is preferably one or more of water-based rose red, acid red, Red-8110, Red-131, and FGR-131.

[0017] The seed treatment agent of the present invention also includes a thickener to increase the viscosity of the dispersion medium and reduce the sedimentation velocity of the particles, thereby improving the stability of the preparation. Preferably, the thickener is one or more of gum arabic, animal glue, pectin, xanthan gum, magnesium aluminum silicate, and bentonite.

[0018] In order to improve the low temperature storage stability of the seed treatment agent, the seed treatment agent of the present invention further adds an antifreeze agent. Preferably, the antifreeze agent is one or more of ethylene glycol, propylene glycol, glycerol, hexylene glycol, urea, ammonium sulfate, sodium chloride, and calcium chloride.

[0019] Preferably, the defoaming agent of the present invention is one or more of silicone, C8-10 fatty alcohol, silicon, C10-20 saturated fatty acid and esters thereof;

[0020] The preservative is one or more of benzoic acid, benzaldehyde, sodium benzoate, potassium benzoate, potassium sorbate and sodium salicylate.

[0021] The preferred seed treatment suspension formulation is as follows:

[0022] Fluopicolide 0.5-5%, azoxystrobin or fludioxonil 1-6%, clothianidin 10-20%, antifreeze agent 1-5%, wetting and dispersing agent 1-10%, thickener 1-4%, film-forming agent 1-5%, colorant 0.1-6%, preservative 0.1-1%, defoamer 0.1-1%, water to make up to 100%.

[0023] The preparation method of the seed treatment suspension of the present invention is as follows: the active ingredients are pulverized by air flow, a wetting agent, a dispersant, a film-forming agent, a colorant, a thickener, an antifreeze agent, a preservative, a defoaming agent and water are completely mixed, and then the mixture is put into a sand mill for grinding according to a proportion until the particle fineness of the suspension reaches D90≤4μm, thereby obtaining the product.

[0024] The seed treatment suspending agent prepared by the invention is a flowable suspension, has qualified low-temperature and heat storage stability, a suspension rate greater than 95%, and a particle fineness D90≤4μm.

[0025] The seed treatment agent of the present invention is used for crop seed treatment. The crop seeds are rice, wheat, corn, cotton, peanut, potato crop seeds; and for preventing and controlling crop diseases and insect pests. The diseases and insect pests include sheath blight, mole, root rot, take-all, smut, corn stem base rot; aphids, grubs, wireworms, and thrips.

[0026] The present invention also provides the following technical solutions:

[0027] Clothianidin was used to enhance the efficacy of the fungicide combination penflufenamide and myclobutanil / fludioxonil against rice sheath blight.

[0028] The fungicide combination pentocyclanil and myclobutanil / fludioxonil was used to enhance the efficacy of clothianidin against rice thrips.

[0029] Beneficial technical effects:

[0030] The seed treatment agent prepared by the present invention is used for crop seed treatment, can achieve simultaneous prevention and control of crop diseases and insect pests, has a significant promoting effect, can significantly reduce the dosage of active ingredients, and slow down the generation of drug resistance of diseases and insect pests. DETAILED DESCRIPTION

[0031] The present invention is further explained below in conjunction with specific implementation modes.

[0032] Example 1.1: Indoor test of compounded agents against rice sheath blight pathogen

[0033] Test strain: Rice sheath blight pathogen (Rhizoctonia solani); collected from the experimental field, isolated, identified and preserved in the laboratory.

[0034] Test reagents: Prepared using commercially available original drugs.

[0035] Test method: The test is conducted by the mycelium growth rate method. A quantitative agent is added according to the set mass concentration to prepare a toxic culture medium containing different amounts of the agent. After it is fully cooled, a 5mm diameter rice sheath blight fungus cake is inoculated. A blank control without the agent is also set up. Each treatment is repeated 3 times. The inoculated plate is placed in an incubator (25°C) for incubation. After 72 hours, the colony growth diameter is measured by the cross method, and then the inhibition rate is calculated.

[0036] Inhibition rate (%) = (control colony growth diameter - treated colony growth diameter) / control colony growth diameter × 100.

[0037] Test results: As shown in Table 1, the combination of fluopicolide and azoxystrobin / fludioxonil / pyraclostrobin has excellent control effect on rice sheath blight, and can significantly inhibit the mycelial growth of rice sheath blight. Clothianidin, dinotefuran, and thiamethoxam belong to neonicotinoid insecticides, and their concentration at 40 mg / L has no inhibitory effect on the mycelial growth of rice sheath blight. After the compound fungicide (fluopicolide and azoxystrobin / fludioxonil / pyraclostrobin) is combined with clothianidin, dinotefuran, and thiamethoxam, the three-way compound agent shows different effects on the mycelial growth of rice sheath blight. Compared with the combination of dinotefuran or thiamethoxam, when the compound fungicide (fluopicolide and azoxystrobin / fludioxonil) is compounded with clothianidin, it improves the inhibitory effect of the fungicide on the mycelial growth of rice sheath blight, and shows a very significant difference with the control effect of the compound fungicide. However, after the compound fungicide (flufenoxam and azoxystrobin / fludioxonil) was compounded with dinotefuran or thiamethoxam, there was no significant difference in the inhibitory effect between it and the compound fungicide itself; in addition, the combination of flufenoxam and pyraclostrobin with clothianidin, dinotefuran, and thiamethoxam did not significantly enhance the inhibitory effect of the fungicide on the mycelial growth of rice sheath blight. The specific mechanism needs further study.

[0038] Table 1.1 Indoor test of compound pesticides against rice sheath blight

[0039]

[0040]

[0041]

[0042] Example 1.2 Indoor test of compound agent against potato black mole pathogen

[0043] Test strain: Rhizoctonia solani, the pathogen causing potato black mole; collected from the test field, isolated, identified and preserved in the laboratory.

[0044] Test reagents: Prepared using commercially available original drugs.

[0045] Test method: The indoor toxicity was determined by the growth rate method. First, the test strain was cultured on a PDA medium plate for 5 days and then used. A 5mm diameter bacterial cake was evenly punched on the cultured colony using a hole puncher. Then, the bacterial cake was inoculated on the drug-containing medium plate treated with different mass concentrations of each test agent, and a blank control without the agent was used. Finally, the test treatment was placed in a biochemical incubator (25°C) for culture. The colony growth diameter was measured using the cross method, and then the antibacterial rate was calculated.

[0046] Inhibition rate (%) = (control colony growth diameter - treated colony growth diameter) / control colony growth diameter × 100.

[0047] Using CTC values ​​to evaluate the combined effects of drugs

[0048] Test results: From Table 1.2, it can be seen that when the mass ratio of trifloxystrobin and fludioxonil is in the range of 1:3-3:1, the composition exhibits a synergistic effect on potato black mole pathogen. From Table 1.3, it can be seen that when the mass ratio of trifloxystrobin and azoxystrobin is in the range of 1:4-6:1, the composition exhibits a synergistic effect on potato black mole pathogen. When the composition exhibits a synergistic effect, the dosage of the active ingredient can be effectively reduced, slowing down the development of drug resistance in the disease.

[0049] Table 1.2 Combined effects of fluazifop and fludioxonil on potato black mole pathogen

[0050]

[0051] Table 1.3 Combined effects of fluazifop-butyl and azoxystrobin on potato black mole pathogen

[0052]

[0053] Example 2 Preparation formula

[0054] 24% Fluorothiocarbamide seed treatment suspension

[0055] Fluopicolide 1%, myclobutanil 4%, clothianidin 19%, sodium lignin sulfonate 3%, sodium dodecylbenzene sulfonate 2%, SP-2700 2%, polyvinyl alcohol 2%, potassium sorbate 0.5%, propylene glycol 2%, xanthan gum 0.15%, acid scarlet 0.2%, silicone oil 0.5%, deionized water to make up 100%.

[0056] 32% Fluorothiocarbamide seed treatment suspension

[0057] Fluoxathiapiprolin 10%, myclobutanil 2%, clothianidin 20%, sodium lignin sulfonate 2%, sodium dodecylbenzene sulfonate 4%, SP-2700 1%, polyvinyl alcohol 3%, potassium sorbate 0.8%, propylene glycol 1.5%, xanthan gum 0.2%, acid scarlet 0.5%, silicone oil 0.5%, deionized water to make up 100%.

[0058] 25% Fluorothiocarbamide seed treatment suspension

[0059] Fluoxathiapiprolin 5%, myclobutanil 5%, clothianidin 15%, sodium lignin sulfonate 1%, sodium dodecylbenzene sulfonate 3%, SP-2700 2%, polyvinyl alcohol 2%, potassium sorbate 0.5%, propylene glycol 2%, xanthan gum 0.1%, acid scarlet 0.5%, silicone oil 0.5%, deionized water to make up 100%.

[0060] 37% Fluorothiocarbamide seed treatment suspension

[0061] Fluoxathiapiprolin 4%, fludioxonil 3%, clothianidin 30%, lakai powder 5%, sodium lauryl sulfate 3%, SP-2700 1%, polyvinyl alcohol 2.5%, sodium benzoate 1%, ethylene glycol 3%, xanthan gum 0.15%, acid scarlet 0.2%, silicone oil 0.5%, deionized water to make up 100%.

[0062] 25% Fluorothiocarbamide seed treatment suspension

[0063] Fluoxathiapiprolin 8%, fludioxonil 2%, clothianidin 15%, lakai powder 3%, sodium lauryl sulfate 2%, SP-2700 3%, polyvinyl alcohol 3%, sodium benzoate 0.5%, ethylene glycol 2%, xanthan gum 0.15%, acid scarlet 0.8%, silicone oil 1%, and deionized water to make up 100%.

[0064] 22% Fluorothiocarbamide seed treatment suspension

[0065] Fluoxathiapiprolin 1%, fludioxonil 2%, clothianidin 19%, lakai powder 4%, sodium lauryl sulfate 2%, SP-2700 2%, polyvinyl alcohol 2.5%, sodium benzoate 0.1%, ethylene glycol 3%, xanthan gum 0.2%, acid scarlet 0.8%, silicone oil 0.3%, deionized water to make up 100%.

[0066] Example 3.1 Field test of compound pesticides against rice diseases and insect pests

[0067] Test crop pests and diseases: rice sheath blight, rice thrips.

[0068] Test agent:

[0069] Treatment 1: 24% Fluorothiocarbamide seed treatment suspension

[0070] Pair 1: Fluoxathiapiprolin 1%, myclobutanil 4%, sodium lignin sulfonate 3%, sodium dodecylbenzene sulfonate 2%, SP-2700 2%, polyvinyl alcohol 2%, potassium sorbate 0.5%, propylene glycol 2%, xanthan gum 0.15%, acid scarlet 0.2%, silicone oil 0.5%, and deionized water to make up 100%.

[0071] Pair 2: clothianidin 19%, sodium lignin sulfonate 3%, sodium dodecylbenzene sulfonate 2%, SP-2700 2%, polyvinyl alcohol 2%, potassium sorbate 0.5%, propylene glycol 2%, xanthan gum 0.15%, acid scarlet 0.2%, silicone oil 0.5%, deionized water to make up 100%.

[0072] Treatment 2: 22% Fluorothiocarbamide seed treatment suspension

[0073] Pair 3: Fluoxathiapiprolin 1%, fludioxonil 2%, lakai powder 4%, sodium lauryl sulfate 2%, SP-2700 2%, polyvinyl alcohol 2.5%, sodium benzoate 0.1%, ethylene glycol 3%, xanthan gum 0.2%, acid scarlet 0.8%, silicone oil 0.3%, and deionized water to make up 100%.

[0074] For 4: clothianidin 19%, lakai powder 4%, sodium lauryl sulfate 2%, SP-2700 2%, polyvinyl alcohol 2.5%, sodium benzoate 0.1%, ethylene glycol 3%, xanthan gum 0.2%, acid scarlet 0.8%, silicone oil 0.3%, and deionized water to make up 100%.

[0075] Test method: For the germination and whitening seeds, mix the agent into a uniform solution according to the seed-to-drug ratio of 80:1, pour it on the seeds, mix and pour it to make the seeds evenly colored, spread them in a ventilated and cool place, dry them and sow them. The area of ​​the plot is 50m 2 ; Repeat three times.

[0076] Methodology:

[0077] 1) Investigation on the control effect of rice thrips: The investigation was conducted 30 days after sowing. A 5-point sampling method was adopted in each plot, and each point was surveyed with an area of ​​25 cm × 25 cm. The total number of leaves, the number of curled tips caused by thrips, the curled tip rate, and the control effect were counted.

[0078] Curled tip rate = number of curled tips / total number of leaves surveyed × 100%;

[0079] Prevention effect = (curling rate of blank control area - curling rate of drug-treated area) / curling rate of blank control area × 100%.

[0080] 2) Survey on rice sheath blight. Survey the incidence of sheath blight every 7 days starting from the end of tillering, for a total of two surveys, and calculate the second prevention effect. For specific survey methods and disease index grading, refer to GB / T17980.20-2000.

[0081] Test results: Using fungicides or insecticides alone for seed treatment can only prevent and control a single pest or disease; using the two in combination can simultaneously prevent and control rice pests and diseases. The fungicide alone (Comparison 1, Comparison 3) combination has a control effect of 74.6% and 84.8% on rice sheath blight respectively; after the fungicide and insecticide are combined, the control effect of treatment 1 and treatment 2 on rice sheath blight is as high as 82.6% and 90.4%. The insecticide alone (Comparison 2, Comparison 4) combination has a control effect of 80.4% and 84.9% on rice thrips respectively; after the fungicide and insecticide are combined, the control effect of treatment 1 and treatment 2 on rice thrips is as high as 90.6% and 93.5%.

[0082] In addition, using dinotefuran and thiamethoxam as comparative tests, the test found that the reinforcing effect of dinotefuran and thiamethoxam on the fungicide combination (fluopoxaban and azoxystrobin / fludioxonil / pyraclostrobin) was not obvious, and there was no significant difference; and the fungicide combination (fluopoxaban and azoxystrobin / fludioxonil / pyraclostrobin) did not enhance the control effect of dinotefuran and thiamethoxam on rice thrips. The combination of fluopoxaban and pyraclostrobin had no synergistic effect on sheath blight and rice thrips when combined with clothianidin, dinotefuran, and thiamethoxam. The specific mechanism needs further study.

[0083] Table 2.1 Field efficacy of compound pesticides against rice diseases and insect pests

[0084]

[0085] Example 3.2 Field test of compound pesticides against potato black mole

[0086] Test crop diseases: potato black mole.

[0087] Test agent: same as Example 3.1

[0088] Test method: Potato field sowing adopts double-row high ridge mulching cultivation mode, 4 replications, random block arrangement, and the area of ​​the plot is 50m 2 . The pesticide application method was to mix the seed potatoes with pesticides before sowing. The incidence of black mole on potato tubers was investigated at harvest. 30 potatoes were harvested from each plot to investigate the incidence of black mole on the tubers. The disease level was divided according to the area of ​​the lesions in the entire tuber:

[0089] Level 0: Tubers have no disease spots;

[0090] Level 1: The lesions are small, and the area of ​​lesions occupies less than 5% of the entire tuber surface area;

[0091] Level 3: The lesions are small, and the area of ​​lesions accounts for 6%-10% of the entire tuber surface area;

[0092] Level 5: The lesions are small or some are large, and the area of ​​lesions accounts for 11%-25% of the entire tuber surface area;

[0093] Level 7: The lesions are evenly distributed in size, and the area of ​​lesions accounts for 26%-50% of the entire tuber surface area;

[0094] Level 9: The lesions are evenly distributed in different sizes, and the area of ​​lesions accounts for more than 51% of the total surface area of ​​the tuber.

[0095] Disease index = Σ(number of diseased potatoes at each level × relative level value) / (total number of potatoes surveyed × 9) × 100; Effect of prevention and control of potato black mole disease / % = [(disease index of control area - disease index of treatment area) / disease index of control area] × 100.

[0096] Test results: The control efficacy of fungicides alone (comparison 1, comparison 3) against potato black spot disease was 80.2% and 87.3% respectively; after combining fungicides and insecticides, the control efficacy of treatments 1 and 2 against potato black spot disease was as high as 88.5% and 94.1%.

[0097] Table 2.2 Field test of compound pesticides against potato black mole

[0098]

[0099]

[0100] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention, rather than to limit it.

Claims

1. A seed treatment agent comprising penflufenacil and clothianidin, characterized in that: The active ingredients include fluopicolide, myclobutanil and clothianidin, wherein the mass ratios of fluopicolide, myclobutanil and clothianidin are 1.5:1.5:20, 2.5:0.5:20 and 0.5:2.5:

20.

2. The seed treatment agent according to claim 1, characterized in that It includes seed treatment suspension, seed treatment emulsion, seed treatment dry powder and seed treatment soluble powder.

3. The seed treatment agent according to claim 1, characterized in that The auxiliary material in the seed treatment agent is selected from at least one of a wetting and dispersing agent, a film former, a colorant, a thickener, an antifreeze agent, a preservative, a defoaming agent, an emulsifier, water, a filler and an organic solvent.

4. A seed treatment agent comprising penflufenacil and clothianidin, characterized in that: The seed treatment agent is a 24% fluoropyrimidine seed treatment suspension, which contains the following ingredients in percentage by weight: 1% of fluopicolide, 4% of myclobutanil, 19% of clothianidin, 3% of sodium lignin sulfonate, 2% of sodium dodecylbenzene sulfonate, 2% of SP-2700, 2% of polyvinyl alcohol, 0.5% of potassium sorbate, 2% of propylene glycol, 0.15% of xanthan gum, 0.2% of acid scarlet, 0.5% of silicone oil, and deionized water makes up to 100%.

5. Use of the seed treatment agent according to any one of claims 1 to 4 for crop seed treatment, characterized in that: Used for the prevention and treatment of crop diseases and insect pests, the crops are wheat and cotton; the diseases or insect pests include sheath blight, black mole disease, and thrips.

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