Triterpenoid Compounds in Ganoderma sinense Fermented Mycelium and Their Anti-Inflammatory Applications
By extracting and purifying eight triterpene compounds from the mycelium of Zizhi fermentation, the problems of low fermentation yield and lack of anti-inflammatory drugs were solved, and significant anti-inflammatory effects were achieved, especially the outstanding anti-inflammatory effects of compounds 2, 7, and 8.
CN115894590BActive Publication Date: 2025-08-01ANHUI FANGGEMEI BIOTECHNOLOGY CO LTD
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Patent Information
- Application Number
- CN202211286894.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2022-10-20
- Publication Date
- 2025-08-01
- Estimated Expiration
- 2042-10-20
AI Technical Summary
Technical Problem
In the prior art, the fermentation yield of Zizhi is low and lacks effective anti-inflammatory drugs or lead compounds, making it difficult to meet market demand.
Method used
Eight triterpene compounds, including compounds 1-8, were extracted and purified from the fermented mycelium of Zizhi, to prepare anti-inflammatory preparations, and achieved anti-inflammatory effects by inhibiting the release of inflammatory factors such as NO, TNF-α and IL-6.
Benefits of technology
The triterpene compounds extracted from the mycelium fermented by Zizhi significantly inhibit the inflammatory response, especially the anti-inflammatory effects of compounds 2, 7, and 8 are outstanding and have broad market application prospects.
✦ Generated by Eureka AI based on patent content.
Abstract
The present invention provides triterpenoid compounds in Ganoderma sinense fermented mycelia. The structural formulas of the triterpenoid compounds are Structural Formulas 1, 3, 4, and 7. The present invention also provides the application of the triterpenoid compounds in Ganoderma sinense fermented mycelia as a drug for preventing or treating inflammation; the triterpenoid compounds in the Ganoderma sinense mycelia are one or more of the compounds with Structural Formulas 1-8. The present invention for the first time conducts an anti-inflammatory activity test on the triterpenoid compounds isolated and purified from Ganoderma sinense mycelia, and finds that the compounds with Structural Formulas 1-8 can all inhibit the release of TNF-α and IL-6, and have significant anti-inflammatory activity.
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