A batch homogenizing and mixing device based on magnetic stirring

Abstract

This invention discloses a batch homogenizing stirring device based on magnetic stirring, comprising a reaction vessel support, a drive disk, and a temperature control device. The temperature control device includes a square container and a heat exchange medium circulation device for providing the heat exchange medium. The reaction vessel support is a support plate with an annular array of clamping holes disposed inside the square container. Each clamping hole holds a reaction vessel, and each reaction vessel contains a magnetic rotor. The drive disk is disposed on the bottom of the square container, and has a drive magnet arranged in an annular array corresponding to the clamping holes. First, the heat exchange medium circulation device is started, then sample material is added to the reaction vessel, and then the drive disk is started to drive the drive magnets to rotate, thereby driving each magnetic rotor to rotate independently to achieve batch stirring. This invention realizes independent homogenizing stirring of reactants, enabling batch chemical reactions or homogenizing stirring.

Description

Technical Field

[0001] This invention belongs to the field of stirred reaction, specifically relating to a batch homogenizing stirring device based on magnetic stirring. It is a reaction system capable of simultaneously batch stirring multiple reaction vessels, enabling not only batch mixing but also, under uniform stirring and temperature control, further investigation of the influence of variable components on the reaction. Background Technology

[0002] Currently, hospital laboratory doctors primarily conduct tests on drugs, blood, or body fluids in test tubes. For some tests, proper stirring is necessary to ensure accuracy. Furthermore, in some gene testing fields, stirring is required due to the need for pretreatment of the test subjects. Among existing instruments, test tube shakers can agitate test tubes, providing some stirring effect. However, test tube shakers are complex in structure and expensive; their primary function is oscillation, not stirring, making them unsuitable for tests requiring stirring pretreatment. Moreover, when dealing with large-scale analysis and testing, stirring pretreatment is required for each test subject, necessitating a separate stirring device for each. This not only complicates equipment but also increases operational difficulty, leading to low work efficiency.

[0003] In addition, for certain chemical reactions, it is necessary to carry out batch independent reactions in a stirred environment to study the impact of changes in reactants on reaction efficiency or product quality, which also requires batch reaction vessels that can be independently stirred. Summary of the Invention

[0004] The purpose of this invention is to propose a batch homogenizing and stirring device based on magnetic stirring, which can stir the reaction in batch reaction vessels without contact. It is suitable for batch reaction experiments in the biological field for homogenizing and stirring or studying the influence of reaction components. The device uses a movable, rotating drive magnet to drive the magnetic rotors inside multiple fixed reaction temperature-controlled containers (such as small test tubes) to rotate, achieving independent batch stirring and homogenization.

[0005] To address the technical problems of current rotating photocatalytic reactors, the technical solution adopted in this invention is as follows:

[0006] The reaction vessel support has several clamping holes arranged in a ring for placing the reaction vessels, and a magnetic rotor for stirring is placed inside each reaction vessel.

[0007] A drive disk is disposed below the reaction vessel support and is concentric with the annular center of the clamping hole. The drive disk is provided with at least two drive magnets distributed in a ring.

[0008] The temperature control device controls the temperature of the reaction vessel through a heat exchange medium;

[0009] The drive disk is driven by a power device to rotate around its own axis. During the rotation, multiple drive magnets on it sweep across the bottom of each reaction vessel in sequence, providing a rotational power magnetic field for the magnetic rotor inside the reaction vessel.

[0010] The clamping holes are evenly distributed on the ring, and the driving magnets are also evenly distributed on the ring. The number and position of the driving magnets correspond one-to-one with the clamping holes.

[0011] Furthermore, the north and south poles of the magnetic rotor are horizontally distributed, and the driving magnets are cylindrical magnets with the north and south poles distributed vertically. The magnetic poles of two adjacent cylindrical magnets are opposite. When two adjacent driving magnets sweep across the bottom of the magnetic rotor, the magnetic rotor is driven to rotate.

[0012] Furthermore, the temperature control device includes a temperature control container that encloses the reaction vessel support and the reaction vessel on it, and a heat exchange medium circulation device for providing heat exchange medium. The outlet of the heat exchange medium circulation device is connected to the medium inlet of the temperature control container through a pipe, and the medium outlet of the temperature control container is connected to the return port of the heat exchange medium circulation device. The heat exchange medium circulation device provides circulating heat exchange medium to the reaction vessel to control the temperature of the reaction vessel to be constant.

[0013] Furthermore, the heat exchange medium is water, and the heat exchange medium circulation device includes a water tank, a temperature regulating device, and a water pump. The inlet of the water pump is connected to the outlet of the water tank, and the outlet of the water pump is the outlet of the heat exchange medium circulation device. The return port of the medium circulation device is the inlet of the temperature regulating device, and the outlet of the temperature regulating device is connected to the inlet of the water tank. The temperature regulating device is used to regulate the temperature of the heat exchange medium returning from the temperature control container.

[0014] Furthermore, the reaction vessel support is a support plate disposed inside the temperature-controlled container, and the support plate is provided with an annular array of clamping holes, the number of which is 2-40.

[0015] Furthermore, the temperature-controlled container is a square container, and the square container is partially or entirely made of transparent material.

[0016] Furthermore, the reaction vessel is a cylindrical container, such as a test tube or a glass tube.

[0017] Furthermore, the maximum distance between the outermost effective magnetic field lines of two adjacent driving magnets is no greater than the length of the magnetic rotor, so that the driving magnets can effectively drive the magnetic rotor 6 to rotate.

[0018] The beneficial effects of this invention are:

[0019] This invention uses a rotating drive magnet to drive the magnetic rotors in each reaction vessel to rotate independently without contact, thereby homogenizing and stirring the reaction materials to be processed in the reaction vessel. Temperature is controlled by a flowing heat exchange medium, which can ensure that the temperature and stirring conditions of all reaction vessels are consistent. It is especially suitable for batch homogenization and mixing and batch experiments to study the effect of reaction components on the reaction. Attached Figure Description

[0020] Figure 1 Front view of the batch homogenizing and mixing device in an embodiment of the present invention;

[0021] Figure 2 Top view of the batch homogenizing and mixing device in an embodiment of the present invention;

[0022] Figure 3 Cross-sectional view of the batch homogenizing and mixing device in an embodiment of the present invention;

[0023] Figure 4 A three-dimensional schematic diagram of the batch homogenizing and stirring device in an embodiment of the present invention;

[0024] Figure 5 A schematic diagram illustrating the principle of the rotating magnetic rotor 6 driven by the driving magnet in the batch homogenizing and stirring device of this invention.

[0025] 1-Reaction vessel support, 101-Support plate, 102-Clamping hole, 3-Drive disc, 301-Drive magnet, 302-Flange seat, 4-Temperature control device, 41-Square container, 43-Heat exchange medium circulation device, 431-Water tank, 432-Temperature regulating device, 433-Water pump, 434-Water supply pipe, 435-Reflux pipe, 5-Test tube, 6-Magnetic rotor, 7-Motor. Detailed Implementation

[0026] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0027] The present invention will be illustrated below using test tube 5 as the reaction vessel and square container 41 as the temperature control vessel as an example.

[0028] Example 1: As Figures 1 to 4 As shown, this embodiment provides a batch homogenizing device based on magnetic stirring, including a reaction vessel support 1, a drive disk 3, and a temperature control device 4.

[0029] like Figures 1 to 3 As shown, the temperature control device 4 includes a square container 41 and a heat exchange medium circulation device 43 for providing circulating heat exchange medium. The outlet of the heat exchange medium circulation device 43 is connected to the medium inlet of the square container 41 through a water supply pipe 434, and the medium outlet of the square container 41 is connected to the return port of the heat exchange medium circulation device 43 through a return pipe 435.

[0030] like Figures 2 to 4 As shown, the reaction vessel support 1 consists of two support plates 101 fixed inside the square container 41. The support plates 101 are provided with clamping holes 102 arranged in a ring array. Each clamping hole 102 can clamp and fix a test tube 5. A circular hole is opened in the middle of the support plate 101 to facilitate the circulation of the heat exchange medium.

[0031] The heat exchange medium circulation device 43 is used to provide circulating heat exchange medium and test tube 5 for heat exchange, so as to control the temperature inside test tube 5 to be constant.

[0032] The drive disk 3 is located below the reaction vessel support 1 outside the square container 41 and is concentric with the annular center of the clamping hole 102. The drive disk 3 is provided with at least two drive magnets 301 arranged in a ring.

[0033] The drive disk 3 is driven to rotate around its own axis by a power device (such as a motor 7). During the rotation, multiple drive magnets 301 on it sequentially sweep across the bottom of each test tube 5, providing a rotational magnetic field for the magnetic rotor 6 inside the test tube 5. This allows the invention to drive the magnetic rotor 6 inside each test tube 5 to rotate independently with only one motor 7. This achieves contactless batch stirring and simplifies the stirring structure in batch devices.

[0034] like Figure 4 and Figure 5 As shown, the magnetic rotor 6 is a cylindrical rotor with its north and south poles horizontally distributed, and the driving magnet 301 is a cylindrical magnet with its north and south poles vertically distributed, with adjacent cylindrical magnets having opposite magnetic poles. When two adjacent driving magnets 301 sweep across the bottom of the magnetic rotor 6, they drive the magnetic rotor 6 to rotate. It should be noted that the distance between the cylindrical magnets and the bottom of the test tube 5 should not be too far, ensuring that the magnetic rotor 6 at the bottom of the test tube 5 is within the magnetic field lines of the cylindrical magnets. The distance between two adjacent driving magnets 301 should also not be too far or too close. Generally, the outermost effective magnetic field lines of two adjacent driving magnets 301 should be approximately tangent, and the maximum distance between the outermost effective magnetic field lines of two adjacent driving magnets 301 should generally not exceed the length of the magnetic rotor 6, so that when two adjacent driving magnets 301 sweep across the bottom of the magnetic rotor 6, they can effectively drive the magnetic rotor 6 to rotate.

[0035] Specifically, in all embodiments of the present invention, the mechanism by which the rotating drive magnet 301 drives the magnetic rotor 6 to rotate without contact is as follows: Figure 5 As shown in the figure, the arrows indicate the rotation direction of the drive disk 3. Figure 5Figure A shows the orientation of a magnetic rotor 6 in a test tube 5, directly above a driving magnet 301. The orientation of the magnetic rotor 6 in the test tube 5 is left N, right S; above the driving magnet 301 is N, below is S; as the driving disk 3 rotates, the magnetic rotor 6 rotates accordingly. When the driving magnet 301 sweeps across the test tube 5, that is, when the test tube 5 is in the middle position between the current driving magnet 301 and the next driving magnet 301, as... Figure 5 As shown in Figure B, the magnetic rotor 6 in test tube 5 reaches a state almost perpendicular to the line connecting the two adjacent driving magnets 301, meaning that the magnetic rotor 6 inside test tube 5 has rotated approximately 90 degrees; when the next driving magnet 301 rotates to directly below test tube 5, as... Figure 5 As shown in Figure C, the next driving magnet 301 has the opposite magnetic pole to the previous one. Therefore, the magnetic rotor 6 is also exactly opposite to its initial state. At this time, the magnetic rotor 6 has rotated exactly 180 degrees. As the ring-shaped driving magnets 301 continue to rotate at the bottom of the test tube 5, the magnetic rotor 6 inside the test tube 5 continues to rotate, completing the stirring function. The principle is the same for other test tubes 5, thus realizing the independent rotation of multiple magnetic rotors 6 driven by a single rotational force, greatly simplifying the mechanical structure of the stirring device. From the above driving principle, it can be seen that the rotational speed of the driving disk 3 determines the rotational speed of the driving magnets 301, and the rotational speed of the driving magnets 301 determines the stirring speed of the magnetic rotor 6. Therefore, by changing the rotational speed of the driving disk 3, the stirring intensity can be adjusted. It can also be concluded that this invention can create batch stirring devices with absolutely identical stirring speeds, thus providing a high-precision equipment foundation for comparative experiments. It can also be seen that the number of driving magnets 301 on the driving disk 3 must be even to ensure that the magnetic poles of any two adjacent driving magnets 301 are opposite, in order to achieve the best stirring effect.

[0036] It should be noted that, in this embodiment of the invention, the temperature control device 4 is not limited to the structure described above, and can be any temperature control device 4, as long as it can satisfy the temperature control of the test tube 5.

[0037] It should be noted that, in this embodiment of the invention, the square container 41 is not limited to square, but can be any shape, as long as it can hold the heat exchange medium and ensure that the reaction part of the test tube 5 is immersed in the heat exchange medium; the material of the container is not limited, and it can be a non-transparent material or a transparent material, so as to facilitate the observation of the reaction in the test tube 5; when the container is made of a non-transparent material, a transparent window can be opened on one side to observe the test tube 5.

[0038] It should be noted that in this embodiment of the invention, the specific shape of the reaction vessel support 1 is not limited, and it can be plate-shaped, ring-shaped, etc., as long as it is provided with a ring array of clamping holes 102. For example, this invention uses two support plates 101 arranged in the vertical direction as the reaction vessel support 1. The support plates 101 are installed in the square container 41 by snap-fit ​​or connector. The two support plates 101 are provided with ring array clamping holes 102 at corresponding positions. The clamping holes 102 of the upper and lower support plates 101 improve the firmness of the fixation of the test tube 5.

[0039] It should be noted that in this embodiment of the invention, the number of clamping holes 102 is not limited and can be selected according to the size of the test tube 5 and the number of test tubes 5 to be batched. Generally speaking, 2-40 clamping holes 102 can be set in a ring array, and specifically, it can be further optimized to 6-20.

[0040] It should be noted that in this embodiment of the invention, the number of driving magnets 301 is at least two. The more driving magnets 301 there are, the better the stirring effect. When the number of driving magnets 301 is the same as the number of clamping holes 102 (test tube 5), the stirring effect reaches the optimal state.

[0041] It should be noted that, in order to ensure the effect, in this embodiment of the invention, the annular array of driving magnets 301 and the annular array of clamping holes 102 are coaxial and have the same radius. That is to say, during the rotation, the driving magnets 301 will sweep past directly below the test tube 5.

[0042] It should be noted that in this embodiment of the invention, the specific shape of the drive disk 3 is not limited, and the size is selected according to the number of drive magnets 301. It can be a solid or hollow disk; the power device can be a motor 7, and the drive disk 3 is mounted on the output shaft of the motor 7 through a flange seat 302.

[0043] It should be noted that in this embodiment of the invention, the type of heat exchange medium is not limited, but water is preferred. The heat exchange medium circulation device 43 includes a water tank 431, a temperature regulating device 432, and a water pump 433. The inlet of the water pump 433 is connected to the outlet of the water tank 431, and the outlet of the water pump 433 is the outlet of the heat exchange medium circulation device 43. It is connected to the medium inlet of the square container 41 through a water supply pipe 434. The return port of the heat exchange medium circulation device 43 is the inlet of the temperature regulating device 432, and the outlet of the temperature regulating device 432 is connected to the inlet of the water tank 431. The temperature regulating device 432 is selected according to the reaction type. If the reaction in the test tube is exothermic, it is set as a heat dissipation fin. If the reaction in the test tube is endothermic, it is set as a heating device. If both exothermic and endothermic processes occur during the reaction, the temperature regulating device 432 can be set as a heat dissipation fin and a heating device connected in parallel. By adjusting the valve opening of the two parallel return mediums, the temperature in the water tank is kept constant. The heat dissipation fin and the heating device can be based on existing technologies.

[0044] It should be noted that, in this embodiment of the invention, in order to improve the degree of automation, a controller can be set to control the power unit and the temperature control device 4, such as controlling the speed of the power unit and the temperature setting of the temperature control device 4.

[0045] It should be noted that, in this embodiment of the invention, the reaction vessel can be a cylindrical container such as a test tube 5 or a beaker, and is not limited to a test tube 5.

[0046] Example 2: Taking an exothermic reaction as an example, this example provides a batch homogenization reaction method based on magnetic stirring, including the following steps:

[0047] First, turn on the heat exchange medium circulation device 43. After the cooling water completes its first circulation, add the reactants (or materials requiring homogenization) and magnetic rotor 6 to the test tube 5 as needed. Slowly place the test tube 5 containing the reactants and magnetic rotor 6 into the clamping hole 102 of the reaction vessel support 1. Then, turn on the power device to drive the drive disk 3 to rotate. The drive disk 3 drives the drive magnet 301 to rotate, sweeping across the bottom of the test tube 5 sequentially, thereby driving the magnetic rotor 6 in each test tube 5 to rotate, realizing the batch stirring function of multiple test tubes 5. The speed of the drive disk 3 can be set by the controller, and the speed of the magnetic rotor 6 can be adjusted to adjust the stirring intensity. The heat generated by the reaction in the test tube is carried away by the heat exchange medium circulation device 43, maintaining a constant reaction temperature in the test tube until the reaction process is completed. After the experiment, turn off the power device and the heat exchange medium circulation device 43 sequentially. The switches and parameter controls corresponding to the above process can all be controlled by the controller. Of course, it can also be set up to be controlled by the industrial control computer through hardware switches or software switches on the touch screen. The specific implementation method does not affect the technical problem solved by the present invention.

[0048] The above embodiments are preferred embodiments of the present invention, but the embodiments of the present invention are not limited to the above embodiments. Any changes, modifications, substitutions, combinations, or simplifications made without departing from the spirit and principle of the present invention are equivalent substitutions and are included within the protection scope of the present invention.

Claims

1. A batch homogenizing and mixing device based on magnetic stirring, characterized in that, include The reaction vessel support has several clamping holes arranged in a ring for placing the reaction vessels, and a magnetic rotor for stirring is placed inside each reaction vessel. A drive disk is disposed below the reaction vessel support and is concentric with the annular center of the clamping hole. The drive disk is provided with at least two drive magnets distributed in a ring. The temperature control device controls the temperature of the reaction vessel through a heat exchange medium; The drive disk is driven by a power device to rotate around its own axis. During the rotation, multiple drive magnets on it sweep across the bottom of each reaction vessel in sequence, providing a rotational power magnetic field for the magnetic rotor inside the reaction vessel. The clamping holes are evenly distributed on the ring, and the number is 6-20. The driving magnets are also evenly distributed on the ring, and the number and position of the driving magnets correspond one-to-one with the clamping holes. The magnetic rotor has its north and south poles horizontally distributed, and the driving magnets are cylindrical magnets with their north and south poles distributed vertically. The magnetic poles of two adjacent cylindrical magnets are opposite. When two adjacent driving magnets sweep across the bottom of the magnetic rotor, the magnetic rotor is driven to rotate. The maximum distance between the outermost effective magnetic field lines of two adjacent driving magnets is no greater than the length of the magnetic rotor.

2. The batch homogenizing and stirring device based on magnetic stirring according to claim 1, characterized in that: the temperature control device includes a temperature control container that encloses the reaction vessel support and the reaction vessel on it, and a heat exchange medium circulation device for providing heat exchange medium, the outlet of the heat exchange medium circulation device is connected to the medium inlet of the temperature control container through a pipe, the medium outlet of the temperature control container is connected to the return port of the heat exchange medium circulation device, and the heat exchange medium circulation device provides circulating heat exchange medium to the reaction vessel to control the temperature of the reaction vessel to be constant.

3. The batch homogenizing and mixing device based on magnetic stirring according to claim 2, characterized in that: The heat exchange medium is water. The heat exchange medium circulation device includes a water tank, a temperature regulating device, and a water pump. The inlet of the water pump is connected to the outlet of the water tank, and the outlet of the water pump is the outlet of the heat exchange medium circulation device. The return port of the medium circulation device is the inlet of the temperature regulating device, and the outlet of the temperature regulating device is connected to the inlet of the water tank. The temperature regulating device is used to regulate the temperature of the heat exchange medium returning from the temperature control container.

4. The batch homogenizing and stirring device based on magnetic stirring according to claim 2, characterized in that: the temperature control container is a square container, and the square container is partially or entirely made of transparent material.

5. The batch homogenizing and mixing device based on magnetic stirring according to claim 1, characterized in that: The reaction vessel is a cylindrical container.

Images