Method of preventing heating film accumulation

Abstract

This invention provides a method for preventing liquid accumulation on a heating film, relating to the field of biopharmaceutical technology. The system for preventing liquid accumulation on a heating film provided by this invention includes: a processing module, a weight detection module, and a heating control module; the weight detection module is connected to the processing module, and the processing module and the heating film are respectively connected to the heating control module; the weight detection module is connected to the heating film and detects the weight of the heating film and the substances on the heating film. This not only allows for timely detection of whether liquid accumulation exists on the heating film, but also enables accurate calculation of the heating time when liquid accumulation occurs, and the heating film evaporates the accumulated liquid, thus timely removing the liquid from the heating film and preventing abnormal system operation due to liquid seepage into the heating film.

Description

Technical Field

[0001] This invention relates to the field of biopharmaceutical technology, and in particular to a method for preventing liquid buildup in a heating membrane. Background Technology

[0002] In biopharmaceutical production, using disposable biobags as reaction vessels offers advantages such as low cost, ease of use, low risk of contamination, and ease of process scale-up. However, in turbulent flow bioreactors, the conical heating surface of the silica gel heating membrane means that leakage from the disposable biobag or residual liquid after replacement can lead to liquid accumulation on the membrane surface. If this accumulation is not addressed promptly, it can seep into the heating membrane, causing short circuits in the resistance wires, localized blackening of the heating membrane, and even system short circuits and tripping, severely impacting normal production. Summary of the Invention

[0003] The purpose of this invention is to provide a method for preventing liquid accumulation on a heating film, thereby alleviating the technical problem of difficulty in timely handling of liquid accumulation on the surface of the heating film.

[0004] In a first aspect, the present invention provides a system for preventing liquid accumulation in a heating film, comprising: a processing module, a weight detection module, and a heating control module;

[0005] The weight detection module is connected to the processing module, and the processing module and the heating film are respectively connected to the heating control module;

[0006] The weight detection module is connected to the heating film and is used to detect the weight of the heating film and the material on the heating film.

[0007] In conjunction with the first aspect, the present invention provides a first possible implementation of the first aspect, wherein the system for preventing liquid accumulation in the heating film further includes a temperature detection module connected to the processing module, and the temperature detection module is used to detect the temperature of the heating film.

[0008] In conjunction with the first aspect, the present invention provides a second possible implementation of the first aspect, wherein the system for preventing liquid accumulation in the heating film further includes a human-machine interaction module, which is connected to the processing module.

[0009] Secondly, the method for preventing liquid accumulation in the heating film provided by the present invention includes the following steps:

[0010] The weight of the heating film and the material on the heating film is detected;

[0011] The presence of liquid accumulation on the heating film is determined based on the detected weight value.

[0012] If there is accumulated liquid, the heating film is controlled to heat up to evaporate the accumulated liquid.

[0013] In conjunction with the second aspect, the present invention provides a first possible implementation of the second aspect, wherein the step of determining whether liquid accumulation exists on the heating film based on the detected weight value includes:

[0014] The detected weight value is compared with a first set value to determine whether the bio-bag on the heating film has been completely removed;

[0015] When the biobag on the heating film is completely removed, the detected weight value is compared with the second set value to determine whether there is liquid accumulation on the heating film.

[0016] In conjunction with the first possible implementation of the second aspect, the present invention provides a second possible implementation of the second aspect, wherein the step of comparing the detected weight value with a second set value to determine whether liquid accumulation exists on the heating film includes:

[0017] If the difference between the detected weight value and the second set value is less than the preset weight difference, it is determined that there is insufficient liquid accumulation on the heating film.

[0018] If the difference between the detected weight value and the second set value is greater than or equal to the preset weight difference, it is determined that there is liquid accumulation in the heating film.

[0019] In conjunction with the second aspect, the present invention provides a third possible implementation of the second aspect, wherein the step of controlling the heating film to heat and evaporate the accumulated liquid includes:

[0020] Detect the temperature of the heating film;

[0021] Calculate the heating time for evaporating the accumulated liquid;

[0022] The heating film is controlled to heat up, and heating is stopped when the heating time ends.

[0023] In conjunction with the third possible implementation of the second aspect, the present invention provides a fourth possible implementation of the second aspect, wherein the step of calculating the heating time for evaporating the accumulated liquid includes:

[0024] According to the formula Calculate the required heating heat, where Q is the required heating heat, W is the weight of the liquid, C is the specific heat capacity of the liquid, ΔT is the difference between the target heating temperature and the test temperature, and n is the ratio of the evaporation heating heat to the heating absorption heat.

[0025] The required heating time is calculated using the formula t=Q / P, where t is the required heating time and P is the power of the heating film.

[0026] In conjunction with the fourth possible implementation of the second aspect, the present invention provides a fifth possible implementation of the second aspect, wherein the target heating temperature is 40°C to 50°C.

[0027] In conjunction with the third possible implementation of the second aspect, the present invention provides a sixth possible implementation of the second aspect, wherein the step of controlling the heating film to heat up includes:

[0028] The initial temperature of the heating film is detected;

[0029] Control the heating film to start heating;

[0030] After a preset heating time, the temperature of the heating film is detected, and it is determined whether the temperature rise of the heating film is greater than or equal to the preset temperature rise value.

[0031] If the temperature rise of the heating film is greater than or equal to the preset temperature rise value, the heating film is controlled to continue heating until the temperature of the heating film reaches the target heating temperature.

[0032] If the temperature rise of the heating film is less than the preset temperature rise value, the heating film is determined to be faulty.

[0033] The embodiments of the present invention bring the following beneficial effects: The weight detection module is connected to the processing module, and the processing module and the heating film are respectively connected to the heating control module. The weight detection module is connected to the heating film. By detecting the weight of the heating film and the material on the heating film, it is possible to not only know in time whether there is liquid accumulation on the heating film through weight detection, but also to evaporate the liquid by heating the heating film when liquid accumulates. This can remove the liquid accumulation on the heating film in time and avoid abnormal system operation caused by liquid seeping into the heating film.

[0034] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, preferred embodiments are described below in detail with reference to the accompanying drawings. Attached Figure Description

[0035] To more clearly illustrate the technical solutions in the specific embodiments or related technologies of the present invention, the drawings used in the description of the specific embodiments or related technologies will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0036] Figure 1 This is a schematic diagram of a system for preventing liquid accumulation in a heating film provided in an embodiment of the present invention;

[0037] Figure 2 This is a schematic flowchart of a method for preventing liquid accumulation in a heating film according to an embodiment of the present invention.

[0038] Icons: 100 - Processing module; 200 - Weight detection module; 300 - Heating control module; 400 - Heating film; 500 - Temperature detection module; 600 - Human-machine interaction module. Detailed Implementation

[0039] The technical solution of the present invention will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0040] In the description of this invention, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing the invention and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance. Physical quantities in formulas, unless otherwise specified, should be understood as basic quantities in the International System of Units (SI), or derived quantities derived from basic quantities through mathematical operations such as multiplication, division, differentiation, or integration.

[0041] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0042] like Figure 1 As shown, the anti-liquidation system for heating film provided in this embodiment of the invention includes: a processing module 100, a weight detection module 200, and a heating control module 300; the weight detection module 200 is connected to the processing module 100, and the processing module 100 and the heating film 400 are respectively connected to the heating control module 300; the weight detection module 200 is connected to the heating film 400, and the weight detection module 200 is used to detect the weight of the heating film 400 and the substance on the heating film 400.

[0043] The liquid accumulation prevention system for the heating membrane described in this embodiment is applicable to turbulent flow bioreactors. After each cell culture batch is completed, the weight detection module 200 detects the weight of the heating membrane 400 and the substances on it to determine whether the disposable biobag on the heating membrane 400 has been removed and whether there is liquid accumulation on the heating membrane 400. When liquid accumulation exists on the heating membrane 400, the heating control module 300 controls the heating membrane 400 to start heating, thereby evaporating the liquid on the heating membrane 400 in a timely manner and preventing system failures such as short circuits caused by liquid seeping into the heating membrane 400.

[0044] In this embodiment of the invention, the system for preventing liquid accumulation in the heating film further includes a temperature detection module 500, which is connected to the processing module 100 and is used to detect the temperature of the heating film 400.

[0045] The temperature detection module 500 can detect the temperature of the heating film 400, thereby not only knowing whether the heating film 400 can achieve the heating function, but also accurately calculating the heating time required to evaporate the liquid based on the temperature of the heating film 400 and the weight of the liquid, so that the liquid can be evaporated in time.

[0046] Furthermore, the system for preventing liquid accumulation on the heating film also includes a human-machine interface module 600, which is connected to the processing module 100.

[0047] Specifically, the human-computer interaction module 600 includes an audible and visual signal indicator, a display, and input devices such as a touch screen or keyboard. The audible and visual signal indicator can issue an audible and visual warning signal when the heating film 400 malfunctions or when there is liquid accumulation on the surface of the heating film 400. The display or touch screen can display the system's working status and related working parameters. The operator can input the setting parameters through the input device to set the heating temperature of the heating film 400.

[0048] like Figure 1 and Figure 2 As shown, the method for preventing liquid accumulation in the heating film provided by the embodiments of the present invention includes the following steps:

[0049] The weight of the heating film 400 and the material on the heating film 400 is measured.

[0050] Determine whether there is liquid accumulation on the heating film 400 based on the detected weight value;

[0051] If there is liquid accumulation, control the heating film 400 to heat and evaporate the liquid.

[0052] Specifically, the weight of the heating membrane 400 and the material on it can indicate whether all disposable bio-bags have been removed from the heating membrane 400. If the weight value still exceeds the standard weight of the heating membrane 400 after the removal of the disposable bio-bags, it proves that there is liquid accumulation on the surface of the heating membrane 400. It should be noted that the turbulent flow bioreactor operates in a clean environment; therefore, apart from possible liquid accumulation, there are no other foreign objects on the surface of the heating membrane 400. When the weight value still exceeds the standard weight of the heating membrane 400, the excess weight can be determined as the weight of liquid accumulation. Therefore, the heating of the heating membrane 400 can be controlled according to the amount of liquid accumulation to ensure complete evaporation of the liquid.

[0053] In this embodiment of the invention, the step of determining whether there is liquid accumulation on the heating film 400 based on the detected weight value includes: comparing the detected weight value with a first set value to determine whether the bio-bag on the heating film 400 has been completely removed; when the bio-bag on the heating film 400 has been completely removed, comparing the detected weight value with a second set value to determine whether there is liquid accumulation on the heating film 400.

[0054] Specifically, the first setting value is the standard weight value when a disposable bio-bag is placed on the heating membrane 400. If the detected weight value is less than the first setting value, it proves that the bio-bag on the heating membrane 400 has been removed. The second setting value is the standard weight value of the heating membrane 400 when the bio-bag is removed. If the detected weight value is greater than the second setting value, in an environment without other foreign objects, it proves that there is liquid accumulation on the heating membrane 400.

[0055] Furthermore, the step of comparing the detected weight value with the second set value to determine whether there is liquid accumulation on the heating film 400 includes: if the difference between the detected weight value and the second set value is less than the preset weight difference, it is determined that there is insufficient liquid accumulation on the heating film 400; if the difference between the detected weight value and the second set value is greater than or equal to the preset weight difference, it is determined that there is liquid accumulation on the heating film 400.

[0056] If the difference between the detected weight value and the second set value is less than the preset weight difference, it indicates that the amount of liquid accumulation is small, or that the weight difference is only a small amount of stain or measurement error. In this case, it is not necessary to control the heating film 400 to heat up and evaporate the liquid. Only when the difference between the detected weight value and the second set value is greater than or equal to the preset weight difference, it indicates that the amount of liquid accumulation is large and meets the standard for treatment. Therefore, it is determined that there is liquid accumulation on the heating film 400, and the heating film 400 needs to be heated to evaporate the liquid.

[0057] Furthermore, the step of controlling the heating film 400 to heat and evaporate the accumulated liquid includes:

[0058] Detect the temperature of the heating film at 400°C;

[0059] Calculate the heating time for evaporating the accumulated liquid;

[0060] The heating film is heated to 400 degrees Celsius, and heating is stopped when the heating time ends.

[0061] During this process, the temperature of the heating film 400 is tested to ensure that the heating film 400 continuously heats the liquid and allows the liquid to evaporate completely. Heating is stopped after the liquid has evaporated to prevent the heating film 400 from burning dry.

[0062] In this embodiment, the step of calculating the heating time for evaporating the accumulated liquid includes:

[0063] According to the formula The required heating heat is calculated, where Q is the required heating heat; W is the weight of the liquid; C is the specific heat capacity of the liquid, which is usually water with a specific heat capacity of 4200 J / (kg·℃); ΔT is the difference between the target heating temperature and the test temperature; and n is the ratio of the evaporation heating heat to the heating absorption heat. Generally, the heat required to evaporate water at its boiling point is five times the heat required to heat the same amount of water from 1℃ to 100℃. Therefore, n can be set to a value of 5, or its value can be finely adjusted according to the actual situation to ensure that the liquid is just evaporated at the end of the heating time.

[0064] The required heating time is calculated using the formula t=Q / P, where t is the required heating time and P is the power of the heating film 400. To ensure accurate heating time and thus ensure that the accumulated liquid is just evaporated at the end of the heating time, the power of the heating film 400 needs to be controlled to ensure stability.

[0065] It should be noted that the target heating temperature is 40℃~50℃. If the detected temperature value is greater than or equal to the target temperature, the heating film 400 will stop working. If the detected temperature value is less than the target temperature, the heating film 400 will continue to be powered on and heat up, thereby maintaining the actual heating temperature of the heating film 400 at the target heating temperature.

[0066] Furthermore, the steps for controlling the heating film to reach a temperature of 400°C include:

[0067] Detect the initial temperature of the heating film 400;

[0068] Control the heating film to start heating at 400;

[0069] After the preset heating time, the temperature of the heating film 400 is detected, and it is determined whether the temperature rise of the heating film 400 is greater than or equal to the preset temperature rise value.

[0070] If the temperature rise of the heating film 400 is greater than or equal to the preset temperature rise value, the heating film 400 is controlled to continue heating until the temperature of the heating film 400 reaches the target heating temperature.

[0071] If the temperature rise of the heating film 400 is less than the preset temperature rise value, the heating film 400 is determined to be faulty.

[0072] During this process, the temperature of the heating membrane 400 is monitored to determine whether it can heat up normally. For example, if the preset heating time is set to 10 seconds and the corresponding preset temperature rise is set to 1°C, if the temperature rise does not exceed 1°C after 10 seconds of heating, it indicates an abnormal temperature rise and a malfunction of the heating membrane 400. In this case, the control program can be stopped, and personnel should be notified to perform maintenance. If the heating membrane 400 heats up normally, its temperature rise is monitored and maintained at the target heating temperature. Heating continues according to the calculated heating time required to evaporate the accumulated liquid. Heating is stopped when the heating time ends, at which point the accumulated liquid on the heating membrane 400 has just evaporated. Upper and lower temperature limits can also be set for the target heating temperature to ensure that the operating temperature of the heating membrane 400 remains safe. Using this method, no additional components or structural modifications to the turbulent flow bioreactor are required. Automatic evaporation of the accumulated liquid can be achieved without increasing configuration costs, ensuring the normal function of the heating membrane 400 and preventing equipment failures such as short circuits.

[0073] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A method for preventing liquid accumulation in a heating film, characterized in that, The method for preventing liquid buildup on the heating membrane is applied to a bioreactor and includes the following steps: The weight of the heating film (400) and the substance on the heating film (400) is detected; The presence of liquid accumulation on the heating film (400) is determined based on the detected weight value. If liquid accumulation exists, the heating film (400) is controlled to heat to evaporate the liquid; The step of determining whether there is liquid accumulation on the heating film (400) based on the detected weight value includes: comparing the detected weight value with a first set value to determine whether the bio-bag on the heating film (400) has been completely removed; when the bio-bag on the heating film (400) has been completely removed, comparing the detected weight value with a second set value to determine whether there is liquid accumulation on the heating film (400); The step of controlling the heating film (400) to heat and evaporate the accumulated liquid includes: detecting the temperature of the heating film (400); calculating the heating time for evaporating the accumulated liquid; controlling the heating film (400) to heat up; and stopping the heating when the heating time ends.

2. The method for preventing liquid accumulation in the heating film according to claim 1, characterized in that, The step of comparing the detected weight value with a second set value to determine whether there is liquid accumulation on the heating film (400) includes: If the difference between the detected weight value and the second set value is less than the preset weight difference, it is determined that there is insufficient liquid accumulation on the heating film (400); If the difference between the detected weight value and the second set value is greater than or equal to the preset weight difference, it is determined that there is liquid accumulation in the heating film (400).

3. The method for preventing liquid accumulation in the heating film according to claim 1, characterized in that, The step of calculating the heating time for evaporating the accumulated liquid includes: According to the formula Calculate the required heating heat, where Q is the required heating heat, W is the weight of the liquid, C is the specific heat capacity of the liquid, ΔT is the difference between the target heating temperature and the test temperature, and n is the ratio of the evaporation heating heat to the heating absorption heat. The required heating time is calculated according to the formula t=Q / P, where t is the required heating time and P is the power of the heating film (400).

4. The method for preventing liquid accumulation in the heating film according to claim 3, characterized in that, The target heating temperature is 40℃~50℃.

5. The method for preventing liquid accumulation in the heating film according to claim 1, characterized in that, The step of controlling the heating film (400) to heat up includes: The initial temperature of the heating film (400) is detected; The heating film (400) is controlled to start heating; After a preset heating time, the temperature of the heating film (400) is detected, and it is determined whether the temperature rise of the heating film (400) is greater than or equal to the preset temperature rise value. If the temperature rise of the heating film (400) is greater than or equal to the preset temperature rise value, the heating film (400) is controlled to continue heating until the temperature of the heating film (400) reaches the target heating temperature; If the temperature rise of the heating film (400) is less than the preset temperature rise value, the heating film (400) is determined to be faulty.

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