A microfluidic chip for a drug delivery system

Abstract

The application discloses a chip body, which is internally provided with a flow channel for mixing liquid, and a plurality of shunt devices are arranged in the middle of the flow channel, and a shunt component is arranged at the center of the interior of the shunt device, so that the solution can be continuously fused and separated, the mixing effect is better, and the mixing time is shortened. The device can realize that parameters in the process are completely controllable in the process of continuous preparation of samples, the delivery speed of the syringe can be controlled, the two-phase liquid is subjected to different impact forces and shearing forces during mixing, and samples with different particle sizes are prepared.

Description

Technical Field

[0001] This invention relates to the field of microfluidic chips, and more particularly to a microfluidic chip for a drug delivery system. Background Technology

[0002] Microfluidic chip technology, based on fluid dynamics theory, integrates basic operational units such as sample preparation, reaction, separation, and detection in biological, chemical, and medical analysis processes onto a single micrometer-scale chip. It precisely controls and manipulates microscale fluids within the chip's micro- and nano-structures, automating the entire analytical process. The immense potential of microfluidic chip technology in biology, chemistry, and medicine has led to its development into a new interdisciplinary research field encompassing biology, chemistry, medicine, fluid dynamics, electronics, materials science, and mechanics.

[0003] The microfluidic chip with publication number CN 113828366 A provides a liquid mixing flow path. By setting up an inverted "S" shaped flow path and a spiral flow path, gas and liquid can be fully mixed. However, because the flow path is set up to be relatively long, the mixing time is also relatively long, and this device cannot prepare the particle size of the mixed sample. Summary of the Invention

[0004] The purpose of this invention is to address the shortcomings of existing technologies by proposing a microfluidic chip for a drug delivery system.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: a microfluidic chip for a drug delivery system, comprising: a chip body, wherein the chip body has a flow channel for mixing liquids inside, and a plurality of flow splitting devices are provided in the middle of the flow channel, wherein a flow splitting component is provided at the center of the flow splitting device, which can continuously fuse and separate the solution, thereby improving the mixing effect and shortening the mixing time.

[0006] As a further description of the above technical solution: the flow channel is Y-shaped, with sections A and B at the top for liquid inlet, and the flow divider is located at the bottom output section, which is arc-shaped.

[0007] As a further description of the above technical solution: the outer side of the chip body is provided with a first Luer connector, a second Luer connector and a liquid outlet column.

[0008] As a further description of the above technical solution: the inlet wall of the first Luer connector is connected to section A above the flow channel, and the inlet wall of the second Luer connector is connected to section B above the flow channel; after the two liquids are fully mixed, they flow out from the outlet column.

[0009] As a further description of the above technical solution: after the two liquids come into contact, they enter the first diversion device on the output section, where the mixture is separated at the diversion component of the first diversion device, and then mixed again after passing through the annular flow channel, and enter the second, third and fourth diversion devices in the same manner.

[0010] As a further description of the above technical solution: the outer side of the ports of the first Luer connector and the second Luer connector are provided with Luer external threads, which are used to connect the syringe.

[0011] As a further description of the above technical solution: the angle of the oblique liquid inflow in sections A and B of the flow channel is b.

[0012] As a further description of the above technical solution: an included angle α is formed between the flow channels of every three flow dividers for buffering.

[0013] As a further description of the above technical solution: the chip body has grooves on both sides.

[0014] As a further description of the above technical solution: by controlling the injection speed of the syringe, the liquid enters the first Luer connector and the second Luer connector at different speeds, thereby preparing samples with different particle sizes.

[0015] The above technical solution has the following advantages or beneficial effects:

[0016] 1. During the continuous preparation of samples, the process parameters are completely controllable. The delivery speed of the syringe can be controlled so that the two liquid phases are subjected to different impact forces and shear forces during mixing, thereby achieving the preparation of samples with different particle sizes.

[0017] 2. Install a flow divider to allow the A and B phase liquids to undergo thorough mixing and reaction through step-by-step cross-convection in a tortuous channel, thereby improving the uniformity and consistency of the product.

[0018] 3. The flow divider is equipped with a flow divider component, which can separate the A and B phases, allowing them to react sequentially and step by step, increasing the countercurrent velocity, and adjusting the flow direction of the A and B phases.

[0019] 4. Setting the output section to an arc shape can increase the turbulence of the mixed liquid, lengthen the path, and increase the reaction time.

[0020] 5. The angles of sections A and B in the flow channel, as well as the included angles of multiple flow dividers, can be adjusted according to actual production conditions. Attached Figure Description

[0021] Figure 1 This is a perspective view of a microfluidic chip for a drug delivery system proposed in this invention;

[0022] Figure 2 This is a front view of a microfluidic chip for a drug delivery system proposed in this invention;

[0023] Figure 3 This is a right view of a microfluidic chip for a drug delivery system proposed in this invention;

[0024] Figure 4 This is an internal structure diagram of a microfluidic chip for a drug delivery system proposed in this invention;

[0025] Figure 5 This is a partial flow path diagram of a microfluidic chip for a drug delivery system proposed in this invention;

[0026] Figure 6 This is a partial three-dimensional view of a microfluidic chip for a drug delivery system proposed in this invention.

[0027] Legend:

[0028] 1. First Luer connector; 2. Second Luer connector; 3. Liquid outlet column; 4. Flow channel; 5. Luer external thread; 6. Groove; 7. Chip body; 100. Diverter component; 200. Output section; 300. Diverter device. Detailed Implementation

[0029] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0030] Reference Figures 1-6 An embodiment of the present invention provides a microfluidic chip for a drug delivery system, comprising: a chip body 7, wherein the chip body 7 has a flow channel 4 for mixing liquids, and a plurality of flow dividers 300 are provided in the middle of the flow channel 4. A flow divider component 100 is provided at the center of the flow divider 300, which can continuously fuse and separate the solution, thereby improving the mixing effect and shortening the mixing time.

[0031] The liquid entering the flow channel 4 can be mixed and divided multiple times through the flow divider 300 and the flow divider component 100 therein, so that the liquid can be fully mixed and uniform.

[0032] Furthermore, the flow channel 4 is Y-shaped, with sections A and B above for liquid inlet, and the diversion device 300 is located in the lower output section 200, which is arc-shaped.

[0033] The two liquids are mixed by entering the flow divider 300 through sections A and B. The mixed liquid enters the output section 200. The output section 200 is designed to be arc-shaped, which can increase the turbulence of the mixed liquid, lengthen the path, and increase the reaction time.

[0034] Furthermore, the outer side of the chip body 7 is provided with a first Luer connector 1, a second Luer connector 2, and a liquid outlet column 3.

[0035] It can enable liquids to enter the microfluidic chip, mix, and then be output.

[0036] Furthermore, the inlet wall of the first Luer connector 1 is connected to section A above the flow channel 4, and the inlet wall of the second Luer connector 2 is connected to section B above the flow channel 4; after the two liquids are fully mixed, they flow out from the outlet column 3.

[0037] It can enable two different liquids to enter the A section of the flow channel 4 from the first Luer connector 1 and the B section of the flow channel 4 from the second Luer connector 2. After mixing, they enter the output section 200 and flow out from the liquid outlet column 3 connected to the output section 200.

[0038] Furthermore, after the two liquids come into contact, they enter the first diversion device on the output section 200, where the mixture is separated at the diversion component 100 of the first diversion device, and then mixed again after passing through the annular flow channel. They then enter the second, third, and fourth diversion devices in the same manner.

[0039] After contact, the two liquids enter the output section 200 for mixing and preparation. They enter from the inlet of the first diverter and are separated for the first time by the diverter component 100. The mixture continues to flow down the flow channel of the first diverter from both sides. The annular flow channel mixes the separated liquids again and flows into the second diverter. The above diverter process is repeated, and the mixture enters the second, third and fourth diverter devices in sequence. This allows for multiple mixing and separation, achieving a better mixing effect.

[0040] Furthermore, the outer side of the ports of the first Luer connector 1 and the second Luer connector 2 are provided with Luer external threads 5, which are used to connect the syringe.

[0041] Luer connectors are convenient connection devices used in the medical industry, enabling quick connection and disconnection of syringes.

[0042] Furthermore, the angle of the oblique inflow of liquid in sections A and B of the flow channel 4 is b.

[0043] Different angles of inclination can be designed according to actual conditions. In this embodiment, the angle b is selected in the range of 85°-120°. This makes the direction of the impact force and shear force on the liquid different when it is mixed after entering the chip, so as to achieve different force effects. This can be used to prepare mixtures with different particle sizes.

[0044] Furthermore, an angle α is formed between the flow channels of every three flow dividers 300 for buffering.

[0045] The liquid can be fully mixed and reacted through the tortuous channel via the diversion device 300, which allows the liquid to pass through the channel in stages through cross-convection. At the same time, it can reduce the impact force of the liquid and change the flow direction, so that the liquid can react in the chip for a longer time. In this embodiment, the included angle α is selected as 120°.

[0046] Furthermore, the chip body 7 has grooves 6 on both sides.

[0047] It can achieve chip clamping and securing during chip installation using a spherical plunger. When the chip is removed, the spherical plunger moves away from structure 6 under external force, thus realizing the clamping and loosening of the chip.

[0048] Furthermore, by controlling the injection speed of the syringe, the liquid enters the first Luer connector 1 and the second Luer connector 2 at different speeds, thereby preparing samples with different particle sizes.

[0049] By controlling the syringe to deliver liquid to the chip at a constant rate and proportion for mixing, and by controlling the speed at which the two liquid phases enter the chip, the sample can achieve turbulent or laminar flow in the microfluidic chip. This allows for the preparation of samples with different particle sizes under different impact and shear forces, with the smallest particle size reaching less than 100 nm and the PDI (Polymer Dispersion Index) below 0.3.

[0050] Working principle: The chip body 1 is equipped with a first Luer connector 1, a second Luer connector 2, and an outlet column 3. The two inlet columns have Luer external threads 5 around their peripheries, which can better fix the syringes. Different syringes control the liquid to enter the flow channel 4 from the first Luer connector 1 and the second Luer connector 2 at a certain ratio and constant speed. By controlling the speed at which the two-phase liquid enters the chip, the sample can reach a turbulent or laminar flow state in the microfluidic chip, thereby achieving the preparation of samples with different particle sizes under different impact forces and shear forces. Depending on the needs, the flow channel angle between section A and section B adopts an oblique inlet angle of 85°-120°. There are four flow splitting devices 300, which adopt a series structure. The flow channel angle between the three consecutive flow splitting devices is designed to be 120° to increase the force of the counter-impact reaction. Then, the mixed prepared liquid is output from the outlet column 3 through the output section 200.

[0051] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A microfluidic chip for a drug delivery system, comprising: The chip body (7) is characterized in that: the chip body (7) is provided with a flow channel (4) for mixing liquids, and a plurality of flow dividers (300) are provided in the middle of the flow channel (4). A flow divider component (100) is provided at the center of the flow divider (300), which can make the solution continuously merge and separate, improve the mixing effect, and shorten the mixing time. The flow channel (4) is Y-shaped, with sections A and B above for liquid inlet, and the flow divider (300) is located in the output section (200) below, and the output section (200) is arc-shaped. The outer side of the chip body (7) is provided with a first Luer connector (1), a second Luer connector (2) and a liquid outlet column (3). The angle of the oblique inlet of liquid in sections A and B of the flow channel (4) is b; An included angle α is formed between the flow channels of every three of the aforementioned diversion devices (300) for buffering; By controlling the injection speed of the syringe, the liquid enters the first Luer connector (1) and the second Luer connector (2) at different speeds, thus preparing samples with different particle sizes.

2. The microfluidic chip for a drug delivery system according to claim 1, characterized in that: The inlet wall of the first Luer connector (1) is connected to section A above the flow channel (4), and the inlet wall of the second Luer connector (2) is connected to section B above the flow channel (4); after the two liquids are fully mixed, they flow out from the outlet column (3).

3. The microfluidic chip for a drug delivery system according to claim 1, characterized in that: After the two liquids come into contact, they enter the first diversion device on the output section (200), where the mixture is separated at the diversion component (100) of the first diversion device. After passing through the annular flow channel, they are mixed again and enter the second, third and fourth diversion devices in the same manner.

4. A microfluidic chip for a drug delivery system according to claim 1, characterized in that: The first Luer connector (1) and the second Luer connector (2) have Luer external threads (5) on the outside of their ports, which are used to connect to a syringe.

5. A microfluidic chip for a drug delivery system according to claim 1, characterized in that: The chip body (7) has grooves (6) on both sides.

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