Blood drop amplitude detection device and consumable thereof

Abstract

The application discloses a blood drop amplitude detection device and a consumable thereof. The blood detection consumable comprises a sample carrier; the sample carrier has a sample adding channel extending downward and a closed cover located below the sample adding channel; a lower channel opening of the sample adding channel is communicated with the closed cover, the lower channel opening is in a spherical arch shape and has a spherical center downward, and the closed cover is light-transmitting and outwardly convex to the sample carrier. The blood detection consumable can be applied to the blood drop amplitude detection device to perform blood drop amplitude detection work. The blood detection consumable can form a hanging blood drop as a carrier, control the amount and morphology of the blood drop, provide a relatively closed and environment-stable space for the blood drop, and meet the observation requirement of the blood drop; the blood drop amplitude detection device can use a mature and low-cost industrial product as a component, reduce development cost, improve detection precision and efficiency, and reduce development difficulty.

Description

Technical Field

[0001] This application relates to the field of blood testing equipment technology, and more particularly to a blood testing consumable. It also relates to a blood droplet amplitude detection device that utilizes the aforementioned blood testing consumable. Background Technology

[0002] Blood droplet amplitude detection is an important part of blood testing.

[0003] Currently, light-emitting diodes (LEDs) and vibrators are commonly used to detect blood drop amplitude. For example, when a blood sample is vibrated by a vibrator, an LED illuminates the blood drop. Due to the obstruction of the blood drop, different shadow areas are left on the photosensitive diode at the rear end during the vibration process, which is used to determine the amplitude of the blood drop.

[0004] The TEG6S instrument is a relatively common instrument used for the aforementioned testing procedures. However, the TEG6S instrument has a complex structure and functional principle, making its development difficult and costly. For example, the consumables of the TEG6S instrument have long and complex flow channels. Therefore, these consumables are often manufactured using a multi-layered membrane composite process. A matching pressure control device is also required to regulate the flow of blood samples within these channels, thereby precisely controlling the amount of blood sample entering a designated location on the consumable. Consequently, the integration of the TEG6S instrument's flow channels and the control of the pump-valve power source present extremely high challenges. Summary of the Invention

[0005] The purpose of this application is to provide a blood testing consumable with a simple and easy-to-use structure, which can be used as a carrier for blood sample to perform blood drop amplitude detection, and has low requirements for supporting equipment. Another purpose of this application is to provide a blood drop amplitude detection device. By using the aforementioned blood testing consumable, the development cost and difficulty can be reduced while achieving blood drop amplitude detection, and the detection accuracy and efficiency can be improved.

[0006] To achieve the above objectives, this application provides a blood testing consumable, including a sample carrier; the sample carrier has a downwardly extending sample dispensing channel and a sealing cover located below the sample dispensing channel; the lower channel opening of the sample dispensing channel is connected to the sealing cover, the lower channel opening is spherical with the center of the sphere facing downward, and the sealing cover is light-transmitting and bulges outward toward the sample carrier.

[0007] In some embodiments, an intermediate channel is provided between the upper and lower channel openings of the sample dispensing channel; the sample dispensing channel gradually narrows from the upper channel opening to the intermediate channel.

[0008] In some embodiments, the intermediate channel is stepped; the lower channel opening gradually widens from the bottom port of the intermediate channel.

[0009] In some embodiments, at least a portion of the enclosure is a transparent film.

[0010] In some embodiments, a sample carrier has multiple sample dispensing channels and multiple protrusions, all of which bulge downwards from the lower surface of the sample carrier, and all lower channel openings are correspondingly located on all protrusions; a shroud is connected to at least two sample dispensing channels, and all protrusions within the same shroud are independent of each other.

[0011] In some embodiments, the sample carrier is strip-shaped; it also includes a plurality of mounting portions disposed on the sample carrier, all mounting portions and all enclosed covers being staggered along the length of the sample carrier.

[0012] In some embodiments, the card-mounting part includes one or more of a magnetic chuck, a snap fastener, a hook and loop fastener, and an adhesive film.

[0013] This application also provides a blood testing consumable using the above-mentioned method, including a vibration loader, a high-speed camera, and a processor; the vibration loader has an output end that vibrates vertically and is used to mount the blood testing consumable, the high-speed camera has a camera head for aligning and photographing the blood testing consumable mounted on the output end, and the processor is coupled to the high-speed camera for acquiring and analyzing image information captured by the high-speed camera.

[0014] In some embodiments, the vibration loader is specifically a bone conduction vibrator.

[0015] In some embodiments, a mounting bracket is also provided at the output end; the mounting bracket has at least two support blocks for fixing the sample carrier and at least one sample slot into which a closure can be embedded; the support blocks protrude outward toward the mounting bracket, and the sample slot is recessed inward toward the mounting bracket and penetrates the mounting bracket; all support blocks and all sample slots are staggered on the same side of the mounting bracket.

[0016] In some embodiments, the system further includes a base; the base is provided with a plurality of vibration loaders, and a high-speed camera is slidably connected to the base, the sliding trajectory of the high-speed camera being parallel to the arrangement trajectory of all the vibration loaders.

[0017] In some embodiments, a fixed-axis rotating semi-transparent lens is also included; a plurality of vibration loaders and camera heads are arranged in a ring around the semi-transparent lens.

[0018] Compared to the aforementioned background technology, the blood testing consumables provided in this application include a sample carrier with a sample dispensing channel and a sealing cover; the sample dispensing channel is located inside the sample carrier and extends downwards, while the sealing cover is located below the sample dispensing channel and bulges outwards from the sample carrier. In this blood testing consumable, the sample dispensing channel has an upper channel opening and a lower channel opening, the lower channel opening being connected to the sealing cover. This lower channel opening is spherical with its center facing downwards, allowing the operator to add a blood sample into the sealing cover through the sample dispensing channel. The blood sample can be suspended as a blood droplet at the lower channel opening; the sealing cover is light-transmitting, surrounds the lower channel opening, and is located outside the sample carrier. Therefore, the blood droplet suspended at the lower channel opening is within the sealing cover, which provides a stable enclosed space for the blood droplet and ensures its observability.

[0019] This blood testing consumable can be used in a blood drop amplitude detection device; in other words, the blood drop amplitude detection device can perform blood drop amplitude detection using this consumable. When using the blood drop amplitude detection device, the consumable is mounted on the device's vibration loader. The device's high-speed camera is aimed at the consumable and the blood drop inside. When the vibration loader drives the consumable and the blood drop to vibrate vertically, the device's processor acquires and analyzes the image information captured by the high-speed camera, thereby obtaining the blood drop amplitude data.

[0020] As can be seen from the above, the blood testing consumables provided in this application can serve as a carrier for blood samples. The blood testing consumables use a sample dispensing channel located within the sample carrier as the main flow channel for the blood sample. This channel is easy to design and manufacture, allowing the blood sample to flow naturally and smoothly to the lower channel opening, where a small amount of blood sample forms a suspended blood droplet. The lower channel opening is located outside the sample carrier, and its shape allows for convenient and effective control of the amount of blood droplets and maintenance of their shape, reducing sample requirements and improving the stability of the blood droplets in their suspended state. The enclosed casing of the blood testing consumables provides a relatively enclosed and stable space for the blood droplets, meeting the requirements for blood droplet observation and improving the stability of the blood droplets and their observation environment. Therefore, the blood testing consumables provided in this application have a simple structure, are easy to design and manufacture, and allow a small and appropriate amount of blood sample to form stable and easily observable suspended blood droplets in a stable and reliable environment, reducing the complexity of its structure, the difficulty of design and manufacturing, and the difficulty of use.

[0021] The blood droplet amplitude detection device provided in this application can utilize mature and inexpensive industrial products as some components, reducing the development cost and difficulty of the device. It can utilize blood testing consumables for amplitude detection experiments, achieving high detection accuracy and efficiency. The blood droplet amplitude detection device provided in this application uses camera image acquisition instead of the photodiode-based method used in the TEG6S to collect optical signals and convert them into electrical signals. Therefore, it significantly reduces the difficulty in optical path design, signal anti-interference, and signal acquisition accuracy, correspondingly lowering development costs and ease of implementation. Attached Figure Description

[0022] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of this application. For those skilled in the art, other drawings can be obtained based on the provided drawings without creative effort.

[0023] Figure 1 This is a schematic diagram of the structure of the blood testing consumables provided in the embodiments of this application;

[0024] Figure 2 This is a cross-sectional view of the blood testing consumables provided in the embodiments of this application;

[0025] Figure 3 An exploded view of some components of the blood droplet amplitude detection device provided in the embodiments of this application;

[0026] Figure 4 This is an assembly diagram of the blood droplet amplitude detection device and blood testing consumables provided in the embodiments of this application;

[0027] Figure 5 This is a schematic diagram of the structure of the vibration loader provided in the embodiments of this application;

[0028] Figure 6 This is a schematic diagram of the structure of the mounting bracket provided in the embodiments of this application;

[0029] Figure 7 This is a schematic diagram of a blood droplet in state a) within the blood testing consumable provided in an embodiment of this application;

[0030] Figure 8 This is a schematic diagram of the structure of a blood droplet in state b) within the blood testing consumable provided in the embodiments of this application;

[0031] Figure 9 This is a schematic diagram of the structure of a blood droplet in state c) within the blood testing consumable provided in the embodiments of this application;

[0032] Figure 10This is a schematic diagram of the structure of the first blood droplet amplitude detection device provided in the embodiments of this application;

[0033] Figure 11 for Figure 10 Top view;

[0034] Figure 12 for Figure 10 The right view;

[0035] Figure 13 This is a schematic diagram of the structure of the second blood droplet amplitude detection device provided in the embodiments of this application;

[0036] Figure 14 This is a flowchart illustrating the operation of the blood droplet amplitude detection device provided in an embodiment of this application.

[0037] Among them, 01-blood droplet, 1-sample carrier, 11-sample dispensing channel, 111-lower channel opening, 112-upper channel opening, 12-sealing cover, 121-transparent film, 122-rigid shell, 13-protrusion, 2-magnetic suction component, 3-vibrator, 31-output end, 4-high-speed camera, 5-mounting bracket, 51-support block, 511-magnet, 52-sample slot, 53-threaded hole, 6-base, 7-semi-transparent lens, 8-counterweight block, 9-clamping and fixing block, 10-partition. Detailed Implementation

[0038] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0039] To enable those skilled in the art to better understand the present application, the present application will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0040] Please refer to Figures 1 to 14 , Figure 1 This is a schematic diagram of the structure of the blood testing consumables provided in the embodiments of this application; Figure 2 This is a cross-sectional view of the blood testing consumables provided in the embodiments of this application;

[0041] Figure 3 An exploded view of some components of the blood droplet amplitude detection device provided in the embodiments of this application; Figure 4 This is an assembly diagram of the blood droplet amplitude detection device and blood testing consumables provided in the embodiments of this application; Figure 5 This is a schematic diagram of the structure of the vibration loader provided in the embodiments of this application; Figure 6This is a schematic diagram of the structure of the mounting bracket provided in the embodiments of this application; Figure 7 This is a schematic diagram of a blood droplet in state a) within the blood testing consumable provided in an embodiment of this application; Figure 8 This is a schematic diagram of the structure of a blood droplet in state b) within the blood testing consumable provided in the embodiments of this application; Figure 9 This is a schematic diagram of the structure of a blood droplet in state c) within the blood testing consumable provided in the embodiments of this application; Figure 10 This is a schematic diagram of the structure of the first blood droplet amplitude detection device provided in the embodiments of this application; Figure 11 for Figure 10 Top view; Figure 12 for Figure 10 The right view; Figure 13 This is a schematic diagram of the structure of the second blood droplet amplitude detection device provided in the embodiments of this application; Figure 14 This is a flowchart illustrating the operation of the blood droplet amplitude detection device provided in an embodiment of this application.

[0042] Please refer to Figure 1 and Figure 2 This application provides a blood testing consumable, including a sample carrier 1; the sample carrier 1 has a sample dispensing channel 11 and a sealing cover 12, the sample dispensing channel 11 is located inside the sample carrier 1 and extends downward, and the sealing cover 12 is located below the sample dispensing channel 11 and bulges outward toward the sample carrier 1.

[0043] In the blood testing consumables, the sample dispensing channel 11 extends downwards. The two ends of this channel along its length can be considered as the upper channel opening 112 and the lower channel opening 111, respectively. The lower channel opening 111 connects to the sealing cover 12, while the upper channel opening 112 can be exposed to the outside of the sample carrier 1 or connected to the product used for sample dispensing. Therefore, the sample dispensing channel 11 of this blood testing consumables can dispense samples into the sealing cover 12; specifically, blood samples enter the sealing cover 12 through the sample dispensing channel 11. Furthermore, the lower channel opening 111 of the sample dispensing channel 11 is spherical with its center facing downwards. When dispensing samples using the sample dispensing channel 11, the operator injects a small amount of blood into the channel. This blood flows downwards along the channel and eventually hangs at the spherical lower channel opening 111, forming a blood droplet 01 suspended at the lower channel opening 111 and within the sealing cover 12.

[0044] For reference Figure 2 , Figures 7 to 9 In this embodiment, the shape of the lower channel opening 111 is not only conducive to controlling the shape and amount of the suspended blood droplet 01, but also to increasing the contact area with the blood droplet 01, which is conducive to improving the connection strength and stability between the lower channel opening 111 and the blood droplet 01, and preventing the blood droplet 01 from detaching from the lower channel opening 111.

[0045] In the blood testing consumables, the sealing cover 12 is located below the sample dispensing channel 11, and the sealing cover 12 is connected to the lower channel opening 111 of the sample dispensing channel 11. Therefore, the blood droplet 01 suspended at the lower channel opening 111 is also inside the sealing cover 12. The aforementioned sealing cover 12 is light-transmitting and bulges outward toward the sample carrier 1. Therefore, the operator or observation instrument can directly observe the blood droplet 01 suspended at the lower channel opening 111 through the sealing cover 12.

[0046] The blood testing consumables provided in this application can be used for blood droplet amplitude detection. As a carrier of blood droplets 01, they can control the amount and maintain the shape of the blood droplets 01, providing a relatively enclosed and stable environment for them. This also meets the requirements for blood droplet observation and can serve as the structural basis for other devices to move or observe the blood droplets 01. Typically, after a blood sample forms a suspended blood droplet 01 within the blood testing consumables, a force can be applied to the consumables to cause the blood droplet 01 to vibrate. Simultaneously, optical and electrical devices can be used to monitor the motion of the blood droplet 01.

[0047] The blood testing consumables provided in this application will be further described below with reference to the accompanying drawings and embodiments.

[0048] In some embodiments, the sample dispensing channel 11 of the blood testing consumable further includes an intermediate channel disposed between the upper channel opening 112 and the lower channel opening 111. In other words, the sample dispensing channel 11 can be divided into an upper channel opening 112, an intermediate channel, and a lower channel opening 111 from top to bottom. To improve the performance of the sample dispensing operation, in this embodiment, the sample dispensing channel 11 gradually narrows from the upper channel opening 112 to the intermediate channel. This means that the radial dimension of the upper channel opening 112 is larger, which is beneficial for the operator to align the product used for sample dispensing, such as a dropper, with the upper channel opening 112 and complete the sample dispensing smoothly. The inner diameter of the intermediate channel gradually narrows from top to bottom, which is beneficial to control the flow rate of the blood sample in the sample dispensing channel 11, reduce the residue of the blood sample in the sample dispensing channel 11, and allow the blood sample to form a blood droplet 01 that meets the operational requirements at the lower channel opening 111 in one go, such as ensuring the volume accuracy of the blood droplet 01.

[0049] Usually, such as Figure 2As shown, the intermediate channel can be configured as a stepped hole. For example, the intermediate channel includes a first channel hole and a second channel hole that are coaxial and connected. The first channel hole is located above the second channel hole, and its upper end communicates with the upper channel opening 112. The lower end of the second channel hole communicates with the lower channel opening 111. In this example, the radial dimension of the upper channel opening 112 can be greater than or equal to the inner diameter of the first channel hole. The inner diameter of the second channel hole is smaller than the inner diameter of the first channel hole, and naturally smaller than the radial dimension of the upper channel opening 112. The radial dimension of the lower channel opening 111 is often also greater than the inner diameter of the second channel hole. For example, the minimum radial dimension of the lower channel opening 111 is equal to the inner diameter of the second channel hole. Since the lower channel opening 111 is spherical, it can be seen that the lower channel opening 111 gradually expands from the second channel hole.

[0050] In some embodiments, at least a portion of the cover 12 of the blood testing consumable is a transparent film 121. For example, the cover 12 may include a transparent rigid shell 122 and a transparent film 121. The top of the cover 12 is in communication with the lower channel opening 111, the rigid shell 122 is located on the periphery of the cover 12, and the transparent film 121 is located at the bottom of the cover 12.

[0051] When a blood droplet 01 is formed at the lower channel opening 111, the rigid shell 122 surrounds the blood droplet 01, providing stable and reliable sealing and protection while ensuring its observability. The transparent film 121 is located below the blood droplet 01, allowing for good heat exchange with the outside environment. For example, the operator can use external heating to maintain the temperature of the blood droplet 01 and its surrounding space. The transparent film 121 does not affect the observability of the blood droplet 01. Therefore, in this embodiment, the rigid shell 122 and the transparent film 121 together provide a small, enclosed environment for the blood droplet 01 suspended at the lower channel opening 111, stabilizing the humidity of the environment and reducing the impact of external evaporation on the detection of the blood droplet 01.

[0052] Please refer to Figure 2 In some embodiments, a sample carrier 1 of the blood testing consumable has multiple sample dispensing channels 11 and multiple protrusions 13; all protrusions 13 bulge downwards from the lower surface of the sample carrier 1, and the lower channel openings 111 of all sample dispensing channels 11 are correspondingly located on all protrusions 13; simultaneously, a sample carrier 1 may be provided with one or more sealing covers 12, any sealing cover 12 communicating with at least two sample dispensing channels 11, that is, any sealing cover 12 encloses at least two lower channel openings 111. In this embodiment, all protrusions 13 within the same sealing cover 12 are independent of each other, and correspondingly, all lower channel openings 111 within the same sealing cover 12 are also independent of each other due to the structural constraints of their respective protrusions 13.

[0053] All the protrusions 13 on the sample carrier 1 are independent of each other and each has a lower channel opening 111. Therefore, all the aforementioned protrusions 13 are equivalent to multiple blood droplet test positions. The protrusions 13 can constrain the distribution of blood samples in each sample application channel 11 and its lower channel opening 111, forming boundary constraints on the blood samples and preventing blood samples from different sample application channels 11 from merging and interfering with the detection. Typically, the protrusion height of the protrusion 13 can be any value between 0.4 mm and 1 mm. The shape of the protrusion 13 can be square, circular, or other irregular shapes.

[0054] Based on the above embodiments, the blood testing consumable sample carrier 1 is strip-shaped, and the strip-shaped sample carrier 1 is provided with multiple mounting parts; for the sample carrier 1, all mounting parts and all sealing covers 12 are staggered along the length direction of the sample carrier 1. For example, a sealing cover 12 is provided between two adjacent mounting parts, and a mounting part is provided between two adjacent sealing covers 12.

[0055] Setting multiple enclosures 12 on a sample carrier 1 can improve detection efficiency and enable multiple sets of tests to be performed at one time. A sample carrier 1 has multiple mounting parts and all mounting parts are evenly distributed along the length of the sample carrier 1, which helps to simplify the installation of the sample carrier 1 with other equipment. In particular, when the sample carrier 1 is connected to the power equipment, it can ensure the consistency of movement of different parts of the sample carrier 1.

[0056] The aforementioned mounting section may include any one or more of the following: magnetic 2, snap fastener, hook fastener, and adhesive film. For example, the mounting section may include magnetic 2, which can be embedded in the sample carrier 1 for magnetic connection with ferromagnetic parts of other devices.

[0057] Please refer to Figures 3 to 9 This application also provides a blood drop amplitude detection device, which uses the blood testing consumables provided in the above embodiments; the blood drop amplitude detection device includes a vibrator 3, a high-speed camera 4 and a processor, wherein the vibrator 3 is connected to the blood testing consumables, and when the vibrator 3 is turned on, the vibrator 3 can vibrate the blood testing consumables and the blood droplets 01 inside them.

[0058] In this blood droplet amplitude detection device, the vibrator 3 has a vertical vibration output end 31, which is used to hold blood testing consumables; the high-speed camera 4 has a camera head, which is used to align and photograph the blood testing consumables held in the output end 31; the processor is coupled to the high-speed camera 4 and can acquire and analyze the image information captured by the high-speed camera 4 to obtain the vibration data of the blood droplet 01 in the blood testing consumables.

[0059] When using this blood droplet amplitude detection device, firstly, the blood testing consumable can be mounted on the output end 31 of the vibrator 3. Then, a blood sample is added to the blood testing consumable, and the alignment between the camera head and the blood testing consumable is adjusted. Next, the vibrator 3 and the high-speed camera 4 are turned on. The vibrator 3 drives the blood droplet 01 inside the blood testing consumable to vibrate vertically, and the high-speed camera 4 captures images of the aforementioned blood droplet 01. Based on a number of images captured by the high-speed camera 4, the processor can analyze the image information in these images, such as capturing the distribution pattern of the blood droplet 01 at different times and measuring relevant size parameters.

[0060] When the vibrator 3 drives the blood droplet 01 inside the blood testing consumable to vibrate vertically, the blood droplet 01 sequentially presents under the vibration excitation of the vibrator 3. Figures 7 to 9 The distribution pattern is shown. The unvibrated, suspended blood droplet 01 initially appears as... Figure 7 In state a) shown, under vibration excitation, blood droplet 01 will move downwards and reach maximum vibration. Here, blood droplet 01 is in the state shown in the diagram. Figure 8 As shown in state b), droplet 01 then moves upward and returns to its original position. Figure 7 As shown in state a), blood droplet 01 continues to move upward and reaches minimum vibration, at which point blood droplet 01 is in... Figure 9 In state c) shown, finally, blood droplet 01 moves downwards and returns to its original position. Figure 7 The state shown in a) forms a vibrational cycle. Here, state a) is the neutral state of the blood droplet within one vibrational cycle.

[0061] Blood droplet amplitude detection devices typically use a bone conduction vibrator as the vibrator. For example, a bone conduction vibrator manufactured by ilouder, model 47mm-8Ω-15w, can be used. Bone conduction vibrators are mature products with high vibration frequency and high motion accuracy, accurately and reliably driving the blood testing consumables and the blood droplets within them. In use, an AC frequency converter signal is input to the bone conduction vibrator, causing its output to reciprocate up and down, thereby driving the blood testing consumables mounted on the vibrator to vibrate in the vertical direction.

[0062] In some embodiments, the blood droplet amplitude detection device further includes a mounting bracket 5; the mounting bracket 5 is connected to the output end of the vibrator 3, in other words, the vibrator 3 uses the mounting bracket 5 to hold the blood testing consumable and transmits motion to the blood testing consumable, causing the blood testing consumable and the blood droplet 01 inside it to vibrate; the mounting bracket 5 has at least two support blocks 51 and at least one sample groove 52, the support blocks 51 protrude outwards from the mounting bracket 5 for fixing the sample carrier 1, the sample groove 52 is recessed inwards from the mounting bracket 5 and penetrates the mounting bracket 5, allowing the enclosure 12 to be embedded. The aforementioned recess of the sample groove 52 inwards from the mounting bracket 5 is mainly to meet the embedding requirements of the enclosure 12; the aforementioned penetration of the sample groove 52 through the mounting bracket 5 is mainly to meet the observation requirements of the enclosure 12. Typically, the recessed direction of the sample groove 52 is different from the through direction of the sample groove 52, for example, the sample groove 52 is recessed inwards from the mounting bracket 5 along the vertical direction and penetrates along other directions besides the vertical direction. In addition, all the support blocks 51 and all the sample slots 52 of a mounting bracket 5 can be staggered and distributed on the same side of the mounting bracket 5.

[0063] For reference Figure 6 and Figure 7 For the aforementioned mounting bracket 5, multiple support blocks 51 can form multiple contact points with the blood testing consumables, improving the connection effect of the blood testing consumables; the sample slot 52 passes through the mounting bracket 5, so that the blood testing consumables in the sample slot 52 can be exposed to the outside world, ensuring the observability of the blood testing consumables and the blood droplets 01 inside.

[0064] When a bone conduction vibrator is used as the vibrator 3, there are certain requirements for the hardness and weight of the mounting bracket 5. For example, the Rockwell hardness of the mounting bracket 5 should be between 60 and 100, and the weight of the mounting bracket 5 should be between 2.5g and 40g. Since the output end of the bone conduction vibrator is mostly a threaded shaft, the lower end of the mounting bracket 5 can be provided with a threaded hole 53 for connecting to the threaded shaft, while the upper end of the mounting bracket 5 can be provided with a magnet 511 for connecting to the magnetic attachment of the blood testing consumables.

[0065] like Figures 10 to 12As shown, the blood droplet amplitude detection device provided in this application also includes a base 6; multiple vibrators 3 can be arranged on the base 6, and a high-speed camera 4 is slidably connected to the base 6, with the sliding trajectory of the high-speed camera 4 parallel to the arrangement trajectory of all the vibrators 3. In this embodiment, the high-speed camera 4 has a high acquisition frequency, often capable of capturing hundreds to thousands of images per second. When the high-speed camera 4 slides relative to the base 6, it can effectively capture images of all the blood testing consumables connected to the vibrators 3, obtaining a sufficient amount of image information for any one vibrator 3; the processor can then perform vibration analysis and recording on the blood droplet 01 morphology in the images captured by the high-speed camera 4. Typically, after analyzing the images captured by the high-speed camera 4, the processor can obtain a curve of the amplitude (Y-axis) versus time (X-axis) of the blood droplet 01.

[0066] In the above embodiments, a blood testing consumable can have multiple sample dispensing channels 11 and multiple sealing covers 12, and a high-speed camera 4 can detect multiple vibrators 3 and the blood testing consumables they are mounted on. It can be seen that the blood droplet amplitude detection device provided in this embodiment can perform multiple sets of tests simultaneously, which greatly improves the testing efficiency.

[0067] In addition, to improve testing efficiency, the blood droplet amplitude detection device can also employ... Figure 13 The structure shown. In Figure 13 In this embodiment, the blood droplet amplitude detection device includes a high-speed camera 4 and multiple vibrators 3, as well as a fixed-axis rotating semi-transparent mirror 7. The camera heads of the multiple vibrators 3 and the high-speed camera 4 are arranged in a ring around the semi-transparent mirror 7. Under the action of the semi-transparent mirror 7, the high-speed camera 4 can detect the blood testing consumables and the blood droplets 01 inside any vibrator 3. In this embodiment, the bodies of the high-speed camera 4 and the vibrators 3 are both stationary, which can avoid introducing more errors into the blood droplet amplitude detection device. The semi-transparent mirror 7 can perform fixed-axis rotational motion driven by a motor. Since the blood droplet amplitude detection device uses the amplitude of the blood droplet 01 as the detection object, the rotational motion of the semi-transparent mirror 7 will not introduce errors into the detection data of the blood droplet amplitude detection device. It can be seen that the aforementioned layout of the high-speed camera 4, vibrators 3, and semi-transparent mirror 7 can simplify the device structure, improve detection accuracy, and reduce the overall footprint of the device, that is, improve space utilization.

[0068] To improve the operational accuracy of the blood drop amplitude detection device, the blood drop amplitude detection device can also be equipped with a counterweight 8, a clamping block 9, and a partition 10 connected to the vibrator 3; the counterweight 8 is located below the vibrator 3, the clamping block 9 surrounds the vibrator 3, and the partition 10 is located above the vibrator 3; the counterweight 8, the clamping block 9, and the partition 10 can be assembled and fixed by fasteners.

[0069] For reference Figure 2 , Figure 3 , Figures 7 to 9 as well as Figure 14 The blood testing consumables and blood drop amplitude detection devices mentioned above can be operated according to the following steps:

[0070] S1: Mount the blood testing consumables onto the blood droplet amplitude detection device;

[0071] S2: Inject a blood sample into the sample application channel 11 of the blood testing consumable to form a blood droplet 01 suspended at the lower channel opening 111;

[0072] S3: Activate the blood drop amplitude detection device when blood drop 01 is within the shooting range of the blood drop amplitude detection device.

[0073] The use of blood testing consumables and blood drop amplitude detection devices mainly includes three steps: loading the card, adding the sample, and testing.

[0074] "Card mounting" refers to mounting the blood testing consumables onto the blood drop amplitude detection device. For example, the blood testing consumables with magnetic attachment are attached to the mounting bracket 5 of the blood drop amplitude detection device.

[0075] When loading blood testing consumables and blood droplet amplitude detection devices, blood samples can be added to the blood testing consumables in advance or after loading. Since the blood sample forms a suspended blood droplet 01 inside the blood testing consumables, in order to ensure the shape of the blood droplet 01, it is usually loaded first and then the sample is added.

[0076] After the blood testing consumables and blood drop amplitude detection device are installed, the operator can use a sampling needle to inject a small amount of blood sample into the sampling channel 11 of the blood testing consumables. These blood samples flow along the sampling channel 11 and form a hanging blood droplet 01 at the lower channel opening 111 of the sampling channel 11.

[0077] After sample addition is completed, the operator can turn on the high-speed camera 4 and vibrator 3 of the blood droplet amplitude detection device, causing the vibrator 3 to vibrate the blood testing consumables and the blood droplets 01 inside, while the high-speed camera 4 captures the vibration state of the blood testing consumables and the blood droplets 01 inside. Obviously, in this step, the blood testing consumables and the blood droplets 01 inside need to be within the shooting range of the high-speed camera 4.

[0078] In summary, the blood testing consumables provided in this application can form a suspended blood droplet 01 from a small amount of blood sample, which can then be used as a carrier for various testing tasks such as blood droplet amplitude detection. The sample application channel 11 and its lower channel opening 111 of the blood testing consumables can conveniently and effectively control the amount of blood droplet 01 and maintain its shape, reducing sample requirements. The enclosed cover 12 of the blood testing consumables provides a relatively enclosed space for the aforementioned blood droplet 01 and meets the requirements for blood droplet observation. The blood droplet amplitude detection device provided in this application uses a high-speed camera 4 to acquire and analyze the vibration state of the blood droplet 01 and convert the data, reducing the environment that introduces errors. Mature and inexpensive industrial products can be used as components, reducing development costs and difficulty. It can be used for amplitude detection experiments on blood testing consumables, with high detection accuracy, high efficiency, and good anti-interference ability during the detection process.

[0079] The above provides a detailed description of the blood droplet amplitude detection device and its consumables provided in this application. Specific examples have been used to illustrate the principles and implementation methods of this application. The descriptions of the embodiments above are merely for the purpose of helping to understand the method and core ideas of this application. It should be noted that those skilled in the art can make various improvements and modifications to this application without departing from its principles, and these improvements and modifications also fall within the protection scope of the claims of this application.

Claims

1. A blood testing consumable, characterized in that, Includes a sample carrier (1); the sample carrier (1) has a downwardly extending sample dispensing channel (11) and a sealing cover (12) located below the sample dispensing channel (11); the lower channel opening (111) of the sample dispensing channel (11) is connected to the sealing cover (12), the lower channel opening (111) is spherical with the center of the sphere facing downward, and the sealing cover (12) is light-transmitting and bulges outward from the sample carrier (1); An intermediate channel is provided between the upper channel opening (112) and the lower channel opening (111) of the sample dispensing channel (11); the sample dispensing channel (11) gradually narrows from the upper channel opening (112) to the intermediate channel; A sample carrier (1) has multiple sample dispensing channels (11) and multiple protrusions (13). All the protrusions (13) bulge downward from the lower surface of the sample carrier (1), and all the lower channel openings (111) are correspondingly located on all the protrusions (13). A sealing cover (12) is connected to at least two sample dispensing channels (11), and all the protrusions (13) within the same sealing cover (12) are independent of each other. The intermediate channel includes a first channel hole and a second channel hole that are coaxial and connected. The first channel hole is located above the second channel hole. The upper end of the first channel hole is connected to the upper channel opening (112), and the lower end of the second channel hole is connected to the lower channel opening (111).

2. The blood testing consumable according to claim 1, characterized in that, The intermediate channel is in the shape of a stepped hole; the lower channel opening (111) gradually expands from the bottom port of the intermediate channel.

3. The blood testing consumable according to claim 1, characterized in that, At least a portion of the enclosure (12) is a transparent film (121).

4. The blood testing consumable according to claim 3, characterized in that, The sample carrier (1) is strip-shaped; it also includes a plurality of mounting parts disposed on the sample carrier (1), and all the mounting parts and all the enclosures (12) are staggered along the length of the sample carrier (1).

5. The blood testing consumable according to claim 4, characterized in that, The mounting part includes any one or more of magnetic components, snap fasteners, adhesive fasteners, and adhesive film components.

6. A blood droplet amplitude detection device, using the blood testing consumables as described in any one of claims 1 to 5, characterized in that, The device includes a vibrator (3), a high-speed camera (4), and a processor; the vibrator (3) has an output end (31) for vertical vibration and for mounting blood testing consumables; the high-speed camera (4) has a camera head for aligning and photographing the blood testing consumables mounted on the output end (31); and the processor is coupled to the high-speed camera (4) for acquiring and analyzing image information captured by the high-speed camera (4).

7. The blood droplet amplitude detection device according to claim 6, characterized in that, The vibrator (3) is specifically a bone conduction vibrator.

8. The blood droplet amplitude detection device according to claim 7, characterized in that, It also includes a mounting bracket (5) disposed at the output end (31); the mounting bracket (5) has at least two support blocks (51) for fixing the sample carrier (1) and at least one sample slot (52) into which the enclosure (12) can be embedded; the support blocks (51) protrude outward toward the mounting bracket (5), and the sample slot (52) is recessed inward toward the mounting bracket (5) and penetrates the mounting bracket (5); all the support blocks (51) and all the sample slots (52) are staggered on the same side of the mounting bracket (5).

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