A high-throughput reactor and system

Abstract

The present invention discloses a high-throughput reactor, which includes a reactor body, a fluid diverter plate, and a reactor cover. The reactor body is provided with a temperature control channel, and a plurality of reaction channels are provided around the temperature control channel. Each reaction channel is provided with a catalyst liner that can be quickly disassembled. The fluid diverter plate is provided with a cavity in which a microfluidic chip can be installed. The microfluidic chip includes a chip inlet and a plurality of chip outlets and fluid restriction channels therebetween. The microfluidic chip is used for uniform distribution of the fluid. The present invention integrates the reactor body, the fluid diverter plate with the microfluidic chip installed, and the reactor cover into a high-throughput reactor, and is applied to a high-throughput reactor system. The control of process conditions such as air velocity, temperature, and pressure is more precise, and the loading and unloading of the catalyst is more convenient.

Description

Technical Field

[0001] The present invention relates to the technical field of high-throughput parallel reaction experiments, and in particular to a high-throughput reactor and system. Background Art

[0002] With the advent of the Industrial 4.0 era, the development of intelligent high-throughput detection technology is in full swing. As the cornerstone of the chemical industry, catalysis plays a vital role. The industry has been conducting research and development of new catalysts to better meet the needs of industrial applications. Catalyst research and development usually involves large amounts of testing, long cycles, and many influencing factors. Conventional single-channel reactors can no longer meet the requirements for rapid screening of catalysts. In order to improve R&D efficiency, researchers have introduced high-throughput detection technology into catalytic reaction evaluation, placing multiple single-channel reactors in parallel to conduct parallel tests of multiple catalytic reactions at the same time. In addition, for reasons of R&D efficiency, experimental safety, cost reduction, and space saving, small-scale experiments are conducted in smaller reactors using a small amount of reagents and samples. This miniaturized / micro-miniaturized experiment has special requirements for the reactor system used.

[0003] At present, most reactor systems at home and abroad still use the traditional single-tube reactor placed in parallel, and sample loading and unloading is complicated and cumbersome. Its temperature is usually controlled by external heating methods such as heating furnaces, oil baths, and sand baths. The heating / cooling rate is slow, the time required for each channel to reach stability is long, and the temperature deviation is large. Traditional reactors still use single or multiple mass flow controllers to control the flow of the corresponding single reaction channel, and configure a corresponding back pressure valve at the outlet of each reaction channel. However, this traditional flow and pressure control method requires a large number of mass flow controllers, flow controllers, and back pressure valves, which greatly increases the equipment space and cost. In order to better compare the experimental results performed in different reaction channels, it is necessary to develop new technical means to accurately control the process conditions such as space velocity, temperature and pressure of high-throughput parallel reaction systems. Summary of the Invention

[0004] In view of the above-mentioned deficiencies in the prior art, the present invention provides an integrated high-throughput reactor and system that can achieve precise control of reaction temperature and uniform distribution of fluid.

[0005] In order to achieve the above-mentioned object of the invention, the technical solution adopted by the present invention is:

[0006] A high-throughput reactor is provided, comprising:

[0007] The reactor body is provided with a temperature control channel, and a plurality of reaction channels are provided around the temperature control channel, each reaction channel is provided with a catalyst liner; a first fluid inlet is provided on the side of the reactor body, a second fluid inlet is provided on the upper end of the reactor body, and a fifth sealing ring is provided on the second fluid inlet;

[0008] A fluid manifold plate having a third fluid inlet on its bottom surface; a cavity for mounting a microfluidic chip is formed at the upper end of the fluid manifold plate, and a sealing ring groove is provided on the periphery of the cavity; a fourth fluid inlet and a corresponding sealing ring groove are formed in the cavity; a plurality of fluid outlets and corresponding sealing ring grooves are provided around the fourth fluid inlet, and the fluid outlets pass through the fluid manifold plate and communicate with the upper ends of the corresponding reaction channels;

[0009] The reactor cover seals the cavity by tightly combining with the sealing ring on the periphery of the cavity.

[0010] Furthermore, a fluid channel is provided inside the reactor body, connecting the first fluid inlet and the second fluid inlet; a fluid channel is provided inside the fluid diverter plate, connecting the third fluid inlet and the fourth fluid inlet; the second fluid inlet corresponds to the third fluid inlet;

[0011] Furthermore, the microfluidic chip comprises:

[0012] A chip mainboard has a chip inlet at its center and a plurality of chip outlets around the chip inlet; the chip inlet and the chip outlets are connected by a fluid restriction channel etched into the chip mainboard; the chip inlet corresponds to the fourth fluid inlet, and the chip outlet corresponds to the fluid outlet;

[0013] The center of the chip sub-board is coaxial with the center of the chip main board.

[0014] Further, the fluid restriction channel includes at least one of a first restriction channel, a second restriction channel, and a third restriction channel;

[0015] The first limiting channel is provided with a plurality of alternating wide channels and narrow channels, which allows two or more reaction fluids entering from the chip inlet to be fully mixed by continuously splitting and merging the reaction fluids;

[0016] A second restricted channel, which is one or a combination of several of a straight-through channel, a mixed channel and a one-way channel;

[0017] The third limiting channel is evenly provided with a plurality of vortex chambers, each of which includes two funnel-shaped structures connected end to end. The one-way flow function of the vortex chamber can prevent fluid backflow.

[0018] Furthermore, a first bolt countersunk hole and a second bolt countersunk hole are opened on the reactor cover, the first bolt countersunk hole and the second bolt countersunk hole are evenly and cross-distributed on the edge of the reactor cover, and the first bolt countersunk hole and the second bolt countersunk hole both pass through the reactor cover;

[0019] A first threaded hole and a bolt through hole are provided on the fluid diverter plate, wherein the first threaded hole does not penetrate the fluid diverter plate, and the bolt through hole penetrates the fluid diverter plate; the first threaded hole corresponds to the first bolt countersunk hole, and the bolt through hole corresponds to the second bolt countersunk hole;

[0020] A second threaded hole is provided at the upper end of the reactor body, and the second threaded hole corresponds to the position of the bolt through hole;

[0021] The reactor cover, the fluid distribution plate with the microfluidic chip installed and the reactor body are integrated into a high-throughput reactor by means of bolts passing through the second bolt countersunk hole, the bolt through hole and the second threaded hole.

[0022] Furthermore, a first sealing ring is provided on the periphery of the cavity, and the cavity in which the microfluidic chip is installed is sealed by the first sealing ring; a second sealing ring is provided on the upper end of the reaction channel, and the catalyst liner installed in the reaction channel is connected to the fluid outlet and sealed by the second sealing ring; a third sealing ring is provided on the periphery of the fourth fluid inlet, and the fourth fluid inlet is connected to the chip inlet and sealed by the third sealing ring; a fourth sealing ring is provided on the periphery of the fluid outlet, and the fluid outlet is connected to the corresponding chip outlet and sealed by the fourth sealing ring.

[0023] Furthermore, the depth of the cavity is not less than the thickness of the microfluidic chip, and the shape of the cavity is adapted to the shape of the microfluidic chip.

[0024] Furthermore, a gas leakage detection hole may be provided at the center of the reactor cover, and the gas leakage detection hole is connected to the detection system through a detection channel.

[0025] Provided is a high-throughput reaction system comprising at least one high-throughput reactor as described above, and further comprising:

[0026] a reaction fluid source for providing a reaction fluid;

[0027] A balancing fluid source for providing balancing fluid;

[0028] a pressure controller connected to a balancing fluid source via a balancing common channel, and the pressure controller is connected to an outlet of the high-throughput reactor via a second fluid channel;

[0029] The switching valve is used for the reaction fluid flowing out of the pressure controller and enters the switching valve through the third fluid channel; the switching valve switches the reaction fluid into the collection device or the analysis system.

[0030] The beneficial effects of the present invention are as follows: compared with the traditional single reactor with cumbersome loading and unloading and single tube for single use, the technical solution of the present invention adopts a modular design, and the reactor with multiple parallel channels is integrated into a module by means of sealing rings and flange fixation; the catalyst is filled into the reactor body in the form of an inner liner tube, making the loading and unloading of the catalyst more convenient, and the disassembly of multiple reaction channels can be completed by only taking out the corresponding catalyst liner tube; a temperature control mode combining internal and external is adopted to make the internal temperature of the reaction channel consistent.

[0031] The present invention utilizes a microfluidic chip to achieve uniform distribution of fluids and adopts a combined internal and external temperature control mode to achieve precise control of reaction temperature. A single pressure controller can achieve simultaneous control of the pressures of multiple reaction channels. These new technical means will facilitate the precise control of process conditions such as space velocity, temperature, and pressure in high-throughput parallel reaction systems. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1 This is a structural diagram of the high-throughput reactor.

[0033] Figure 2 A top view of the fluid manifold.

[0034] Figure 3 This is a bottom view of the fluid diverter plate.

[0035] Figure 4 A cross-sectional view of the reactor module.

[0036] Figure 5 Schematic diagram of the heating and insulation structure wrapped around the outside of the reactor body.

[0037] Figure 6 Schematic diagram of the structure of the microfluidic chip.

[0038] Figure 7 Schematic diagram of the high-throughput reactor system.

[0039] Wherein: 1-microfluidic chip; 2-high-throughput reactor; 3-pressure control module; 4-reactor cover; 5-fluid diverter plate; 6-reactor body; 10-reaction fluid source; 11-first fluid channel; 12-chip inlet; 13-first restriction channel; 14-second restriction channel; 15-third restriction channel; 16-chip outlet; 17-pressure sensor; 18-reactor inlet; 19-reactor; 20-catalyst bed; 21-second fluid channel; 22-pressure controller; 23-balance fluid source; 24-balance common channel; 25-third fluid channel; 26-switching valve; 27-collection device; 28-distribution Analysis system; 41-first bolt countersunk hole; 42-second bolt countersunk hole; 43-leakage detection hole; 51-first threaded hole; 52-bolt through hole; 53-first sealing ring; 54-cavity; 61-second threaded hole; 62-reaction channel; 63-temperature control channel; 64-second sealing ring; 71-heating layer; 72-lining layer; 73-insulation layer; 74-outer protective layer; 110-chip main board; 111-chip sub-board; 120-fluid outlet; 121-third fluid inlet; 122-fourth fluid inlet; 123-first fluid inlet; 124-second fluid inlet; 125-third sealing ring; 126-fourth sealing ring. DETAILED DESCRIPTION

[0040] The specific embodiments of the present invention are described below to facilitate understanding of the present invention by those skilled in the art. However, it should be clear that the present invention is not limited to the scope of the specific embodiments. For those skilled in the art, as long as various changes are within the spirit and scope of the present invention as defined and determined by the appended claims, these changes are obvious, and all inventions and creations utilizing the concepts of the present invention are protected.

[0041] Example 1

[0042] For ease of understanding, the following technical solutions will be combined Figures 1-4 The modules of the medium and high flux reactor are described from different angles.

[0043] Example 1 provides a high-throughput reactor 2 , comprising a reactor cover 4 , a fluid diverter plate 5 and a reactor body 6 .

[0044] Reactor cover 4 is provided with a first bolt countersunk hole 41 and a second bolt countersunk hole 42, which are evenly distributed along the edge of reactor cover 4 and penetrate the reactor cover 4. A gas leak detection hole 43 is provided in the center of reactor cover 4. Gas leak detection hole 43 is connected to a gas leak detection system via a detection channel, which is used to detect whether the microfluidic chip in the fluid diverter plate 5 is damaged or leaking.

[0045] The fluid diverter plate 5 is provided with a first threaded hole 51 and a bolt through hole 52. Figure 2 and looking up Figure 3 As shown, the first threaded hole 51 does not penetrate the fluid diverter plate 5 , the bolt through hole 52 penetrates the fluid diverter plate 5 , the first threaded hole 51 corresponds to the first bolt countersunk hole 41 , and the bolt through hole 52 corresponds to the second bolt countersunk hole 42 .

[0046] like Figure 2 As shown, a cavity 54 is provided in the middle of the fluid manifold plate 5 for accommodating the microfluidic chip 1. This embodiment shows a square cavity 54. The shape and depth of the cavity 54 can be adjusted to suit the shape and thickness of the microfluidic chip 1. A fourth fluid inlet 122 and a slot corresponding to the third sealing ring 125 are defined within the cavity 54. Four fluid outlets 120 and slots corresponding to the fourth sealing ring 126 are also defined around the cavity 54.

[0047] like Figure 3 As shown, a third fluid inlet 121 is defined on the bottom surface of the fluid manifold plate 5, and a fluid outlet 120 extends through the fluid manifold plate 5. A fluid channel is defined within the fluid manifold plate 5, connecting the third fluid inlet 121 and the fourth fluid inlet 122. Bolts of appropriate length are used through first bolt counterbores 41 and first threaded holes 51 to tightly couple the reactor cover 4 and the fluid manifold plate 5. A first sealing ring 53 seals the cavity 54, thereby forming a single unit with the reactor cover 4, microfluidic chip 1, and fluid manifold plate 5. This unit is then removed during catalyst loading and unloading.

[0048] A first fluid inlet 123 is provided on the side of the reactor body 6, a second fluid inlet 124 is provided at the upper end of the reactor body 6, and a fluid channel is provided inside the reactor body 6 to connect the first fluid inlet 123 and the second fluid inlet 124; the second fluid inlet 124 corresponds to the position of the third fluid inlet 121.

[0049] A second threaded hole 61 is provided at the upper end of the reactor body 6, and the second threaded hole 61 corresponds to the position of the bolt through hole 52. Bolts of corresponding length are passed through the second bolt countersunk hole 42, the bolt through hole 52 and the second threaded hole 61 to integrate the reactor cover 4, the fluid diversion plate 5 and the reactor body 6 into a high-throughput reactor 2.

[0050] like Figure 4As shown in the cross-sectional view of the reactor body 6, a reaction channel 62 is provided within the reactor body 6, into which a catalyst liner can be installed. Specifically, the reaction fluid passes through the first fluid inlet 123 and the second fluid inlet 124 in the reactor body 6, enters the third fluid inlet 121 and the fourth fluid inlet 122 of the fluid diverter plate 5, and then enters the chip inlet 12 of the microfluidic chip 1. After being diverted by the microfluidic chip, it enters the corresponding fluid outlet 120 from the chip outlet 16 and flows to the corresponding reaction channel 62. The reaction channel 62 and the fluid outlet 120 are sealed by a second sealing ring 64, the fourth fluid inlet 122 and the chip inlet 12 are sealed by a third sealing ring 125, and the chip outlet 16 and the corresponding fluid outlet 120 are sealed by a fourth sealing ring 126.

[0051] The center of the reactor body 6 is also provided with a temperature control channel 63 for installing an internal temperature control module. In order to achieve a uniform temperature inside the reaction channel 62 and ensure the balance of the internal and external temperatures, Figure 5 The embodiment shown can also wrap the heating layer 71 on the outer wall of the reactor body 6, that is, adopt a combination of internal and external temperature control, and the inner lining layer 72, the insulation layer 73 and the outer protective layer 74 are sequentially provided outside the heating layer 71.

[0052] Compared with traditional single reactors with complicated loading and unloading and single-tube single use, the present invention adopts a modular design, integrating reactors with multiple parallel reaction channels into a high-throughput reactor through sealing with sealing rings and fixing with flanges; the catalyst is filled into the reaction sleeve in the form of an inner liner tube, making the loading and unloading of the catalyst more convenient, and the disassembly of multiple reaction channels can be completed by simply taking out the corresponding reaction sleeve; a temperature control mode combining internal and external factors is adopted to ensure consistent temperature inside the reaction channel.

[0053] Example 2

[0054] like Figure 6 As shown, this embodiment provides a microfluidic chip 1, including a chip main board 110, a chip sub-board 111, a chip inlet 12, a fluid restriction channel and a chip outlet 16.

[0055] The chip main board 110 and chip sub-board 111 are made of fluid-resistant materials such as silicon, quartz, glass, or metal. The center of the chip main board 110 is coaxial with the center of the chip sub-board 111. The length and width of the chip sub-board 111 must at least cover all fluid channels in the chip main board 110 (including the chip inlet 12, the fluid confinement channel, and the chip outlet 16). Figure 6 Only the chip main board 110 and the chip sub-board 111 are shown as square. It can be understood that the chip main board 110 and the chip sub-board 111 can also be replaced with circular, hexagonal or other shapes to meet specific installation and use requirements.

[0056] The chip inlet 12 is located at the center of the chip main board 110. Optionally, the chip inlet 12 can also be located at the center of the chip sub-board 111. The chip inlet 12 and the chip outlet 16 are connected by a fluid restriction channel, which is etched in the chip main board 110. The fluid restriction channel uses different pores in the micron to millimeter range according to different fluid flow rate and pressure requirements. Figure 6 The fluid confinement channel in the example uses micron-scale pores.

[0057] The fluid confinement channel includes a first confinement channel 13 , a second confinement channel 14 and a third confinement channel 15 which sequentially connect the chip inlet 12 and the chip outlet 16 .

[0058] The first limiting channel 13 is provided with a plurality of alternating wide channels and narrow channels, which can continuously split and merge the reaction fluids, thereby allowing two or more reaction fluids entering from the chip inlet 12 to be fully mixed.

[0059] The second limiting channel 14 is a straight-through channel, a mixed channel, and a one-way channel, or a mixture of several channels to meet different practical application requirements.

[0060] A plurality of vortex chambers are evenly arranged on the third limiting channel 15. The vortex chambers include two funnel-shaped structures connected end to end. The unidirectional flow function of the vortex chambers prevents fluid backflow.

[0061] exist Figure 6 In the example shown, the chip inlet 12 is connected to four fluid restriction channels, and the end of each fluid restriction channel is connected to a corresponding chip outlet 16. For example, the pressure of the reaction fluid at the chip inlet 12 is P1, and the pressure after entering the four fluid restriction channels and reaching the chip outlet 16 is P2. To ensure that the reaction fluid is evenly distributed to the four fluid channels, that is, the pressure difference P1-P2 from the chip inlet 12 to the chip outlet 16 corresponding to the four flow channels is consistent, the combination of each fluid channel and the function and length of each fluid restriction channel segment must be consistent.

[0062] Figure 6 Only four identical fluid restriction channels are shown. Other combinations of fluid restriction channels and corresponding adjustments to the lengths of each fluid restriction channel segment will be readily apparent to those skilled in the art. Alternatively, 8, 12, 16, or even more fluid restriction channels may be arranged to meet actual application requirements.

[0063] Example 3

[0064] like Figure 7 As shown, Example 3 provides a high-throughput reactor system, including a high-throughput reactor 2 and a pressure controller module 3.

[0065] The high-throughput reactor 2 includes a microfluidic chip 1, which includes a chip inlet 12, a fluid restriction channel, and a chip outlet 16. The chip inlet 12 is connected to a reaction fluid source 10, which is used to provide a reaction fluid. The reaction fluid enters the chip inlet 12 from the reaction fluid source 10 through a first fluid channel 11. The reaction fluid can be at least one of a gas or a liquid. This embodiment only shows the case where the reaction fluid is diverted to four identical fluid restriction channels via the chip inlet 12.

[0066] The high-throughput reactor 2 includes a reactor 19, which is connected to the chip outlet 16. After the reaction fluid flows out of the chip outlet 16, it is transported into the reactor 19 through the reactor inlet 18. A pressure sensor 17 is provided between the reactor inlet 18 and the chip outlet 16. The pressure sensor 17 monitors the fluid pressure P3 in real time. The reaction fluid enters the reactor 19 and undergoes a catalytic reaction in the catalyst bed 20. It should be noted that the number of reactors corresponds to the number of the aforementioned diverted fluid restriction channels. This embodiment shows the case of four reactors, but any number greater than one is a feasible solution for this embodiment.

[0067] The pressure control module 3 includes a pressure controller 22 and a balancing fluid source 23. The pressure controller 22 is connected to the reactor 19 via a second fluid channel 21 and is connected to the balancing fluid source 23 via a common balancing channel 24. The function of the pressure controller 22 is to adjust the pressure of the reaction fluid passing through the reactor 19 (i.e., the value P3 of the pressure sensor 17) and the pressure P4 of the balancing fluid to be the same (P3 = P4).

[0068] The high-throughput reactor system of this embodiment further includes a switching valve 26 . The reaction fluid flows out of the pressure controller 22 and enters the switching valve 26 through the third fluid channel 25 . Figure 7 The diagram shows the situation where four reaction fluids enter the switching valve 26 . The switching valve 26 is a four-position six-way valve. The four reaction fluids are switched through the switching valve 26 to enter the collection device 27 or the analysis system 28 .

[0069] The above technical solution utilizes the microfluidic chip 1 to achieve uniform distribution of the fluid, adopts a combined internal and external temperature control mode to achieve precise control of the reaction temperature, and develops a single pressure controller to achieve simultaneous control of the pressures of multiple reaction channels. These new technical means will facilitate the precise control of process conditions such as space velocity, temperature, and pressure in high-throughput parallel reaction systems.

[0070] The following takes the example of the fluid being divided into four fluid restriction channels through the microfluidic chip 1 and entering the corresponding four reaction channels 62 to specifically illustrate the actual working condition of the reactor module.

[0071] Table 1 Flow control of each channel when the reactor outlet pressure is controlled at 30 bar

[0072]

[0073] From the test results in Table 1, it can be concluded that when the outlet pressure of each reaction channel 62 is regulated to 30 bar by the pressure controller, the flow rates of each channel are 13.40 ml / min, 13.32 ml / min, 13.45 ml / min, and 13.24 ml / min, respectively, and the corresponding deviations are 0.3%, -0.2%, 0.7%, and -0.8%, respectively, indicating that the flow control of each channel is relatively stable and the deviation is not large.

[0074] Table 2 Flow control of each channel when the reactor outlet pressure is controlled at 60 bar

[0075]

[0076] From the test results in Table 2, it can be concluded that when the outlet pressure of each reaction channel 62 is regulated to 30 bar by the pressure controller, the flow rates of each channel are 13.34 ml / min, 13.25 ml / min, 13.16 ml / min, and 13.18 ml / min, respectively, and the corresponding deviations are 0.8%, 0.1%, -0.5%, and -0.4%, respectively, indicating that the flow control of each channel is relatively stable and the deviation is not large.

Claims

1. A high-throughput reactor, characterized in that include: A reactor body is provided with a temperature control channel, and a plurality of reaction channels are provided around the temperature control channel, each of which is provided with a catalyst liner; a first fluid inlet is provided on the side of the reactor body, and a second fluid inlet is provided on the upper end of the reactor body; A fluid diverter plate having a third fluid inlet on its bottom surface; a cavity for mounting a microfluidic chip is formed at the upper end of the fluid diverter plate, and a sealing ring groove is provided on the periphery of the cavity; a fourth fluid inlet and a corresponding sealing ring groove are formed within the cavity; a plurality of fluid outlets and corresponding sealing ring grooves are provided around the fourth fluid inlet, and the fluid outlets pass through the fluid diverter plate and communicate with the upper ends of the corresponding reaction channels; The reactor cover seals the cavity by tightly combining with the sealing ring on the periphery of the cavity; A fluid channel is provided inside the reactor body, connecting the first fluid inlet and the second fluid inlet; a fluid channel is provided inside the fluid diverter plate, connecting the third fluid inlet and the fourth fluid inlet; the second fluid inlet corresponds to the third fluid inlet; The microfluidic chip comprises: a chip mainboard, wherein a chip inlet is provided at the center thereof, and a plurality of chip outlets are provided around the chip inlet; the chip inlet and the chip outlets are connected via a fluid restriction channel, and the fluid restriction channel is etched in the chip mainboard; the chip inlet corresponds to the fourth fluid inlet, and the chip outlet corresponds to the fluid outlet; The center of the chip sub-board is coaxial with the center of the chip main board.

2. The high-throughput reactor according to claim 1, characterized in that The fluid restriction channel includes at least one of a first restriction channel, a second restriction channel, and a third restriction channel; The first restriction channel is provided with a plurality of alternating wide channels and narrow channels, which allows two or more reaction fluids entering from the chip inlet to be fully mixed by continuously splitting and merging the reaction fluids; The second restricted channel is one or a combination of several channels selected from the group consisting of a straight-through channel, a mixed channel and a one-way channel; The third limiting channel is evenly provided with a plurality of vortex chambers, each of which comprises two funnel-shaped structures connected end to end. The one-way flow function of the vortex chamber can prevent fluid backflow.

3. The high-throughput reactor according to claim 1, characterized in that The reactor cover is provided with a first bolt countersunk hole and a second bolt countersunk hole, the first bolt countersunk hole and the second bolt countersunk hole are evenly and cross-distributed on the edge of the reactor cover, and the first bolt countersunk hole and the second bolt countersunk hole both pass through the reactor cover; A first threaded hole and a bolt through hole are provided on the fluid diverter plate, wherein the first threaded hole does not penetrate the fluid diverter plate, and the bolt through hole penetrates the fluid diverter plate; the first threaded hole corresponds to the first bolt countersunk hole, and the bolt through hole corresponds to the second bolt countersunk hole; A second threaded hole is formed at the upper end of the reactor body, and the second threaded hole corresponds to the position of the bolt through hole; The reactor cover, the fluid distribution plate with the microfluidic chip installed and the reactor body are integrated into a high-throughput reactor by means of bolts passing through the second bolt countersunk hole, the bolt through hole and the second threaded hole.

4. The high-throughput reactor according to claim 1, characterized in that A first sealing ring is provided on the periphery of the cavity, and the cavity where the microfluidic chip is installed is sealed by the first sealing ring; a second sealing ring is provided on the upper end of the reaction channel, and the catalyst liner installed in the reaction channel is connected to the fluid outlet and sealed by the second sealing ring; a third sealing ring is provided on the periphery of the fourth fluid inlet, and the fourth fluid inlet is connected to the chip inlet and sealed by the third sealing ring; a fourth sealing ring is provided on the periphery of the fluid outlet, and the fluid outlet is connected to the corresponding chip outlet and sealed by the fourth sealing ring.

5. The high-throughput reactor according to claim 1, characterized in that The depth of the cavity is not less than the thickness of the microfluidic chip, and the shape of the cavity is adapted to the shape of the microfluidic chip.

6. The high-throughput reactor according to claim 1, characterized in that A gas leakage detection hole may be provided at the center of the reactor cover, and the gas leakage detection hole is connected to a detection system through a detection channel.

7. A high-throughput reaction system, characterized in that The high-throughput reactor according to any one of claims 1 to 6 further comprises: a reaction fluid source for providing a reaction fluid; A balancing fluid source for providing balancing fluid; a pressure controller connected to a balancing fluid source via a balancing common channel, and the pressure controller is connected to an outlet of the high-throughput reactor via a second fluid channel; The switching valve is used for switching the reaction fluid flowing out of the pressure controller into the switching valve via the third fluid channel; the switching valve switches the reaction fluid into the collection device or the analysis system.

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