A multi-channel whitening composition and its preparation method and application

Abstract

The invention discloses a multi-pathway whitening composition and its preparation method and application, the multi-pathway whitening composition includes 0.1-2 parts of melanin formation inhibitor; 0.1-10 parts of melanin transport inhibitor; 0.1-3 parts of melanin metabolism promoter; 10-70 parts of other additives; the melanin transport inhibitor is composed of nicotinamide, squalane, erythritol, shea butter, and water. The multi-pathway whitening composition is composed of components such as melanin formation inhibitor, melanin transport inhibitor, and melanin metabolism promoter. Based on three pathways of skin darkening, a whitening raw material composition is configured from three aspects: melanin formation, melanin transport, and melanin metabolism. A whitening effect is achieved, and by forming nicotinamide into inclusions by components such as squalane, erythritol, shea butter, and water in an oil-in-water manner, the side effects of nicotinamide are reduced, and nicotinamide can be buffered and released to exert its effect.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetic materials, and in particular to a multi-channel whitening composition, a preparation method and an application thereof. Background Art

[0002] With the advancement of society and technology, whitening ingredients are becoming increasingly common. Non-toxic and side-effect-free whitening ingredients are a key priority. They prioritize healthy skin whitening without disrupting normal skin metabolism, accelerating melanin metabolism and preventing excessive melanin accumulation that can cause dark spots. However, whitening products often suffer from issues such as poor efficacy and product instability, and even lead to side effects such as darkening, freckles, and aggravated skin reactions. Therefore, the rational design of whitening cosmetic formulas is crucial.

[0003] Skin color is regulated by a variety of factors, but primarily by the content and distribution of melanin. Melanin is produced by melanocytes, located in the basal layer of the epidermis. Melanin determines skin color by synthesizing melanin and also protects the body from UV damage by absorbing ultraviolet rays. Some melanin produced in the body is broken down, dissolved, and absorbed within the skin, excreted through the blood and kidneys. The remaining melanin is transported to the stratum corneum via dendritic processes, where it accumulates and forms a darkening effect. This is ultimately eliminated with the shedding of epidermal cells. Insufficient or abnormal stratum corneum metabolism results in skin spots, dull skin tone, and darkening. Therefore, based on the mechanisms of melanin formation, whitening mechanisms can be categorized into three types: the first, blocking melanin production. Tyrosinase, contained in melanocytes, oxidizes tyrosine into polysaccharides, which, through a series of metabolic processes, ultimately produce melanin. Antioxidant active ingredients reduce the oxidation products involved in melanin production, thereby blocking melanin production. In addition, antioxidants can inhibit the activity of free radicals caused by ultraviolet rays, haze, etc., thereby slowing down the aging and dull skin tone caused by the oxidation of skin collagen. It is worth noting that melanocytes are present in the basal layer of the skin epidermis, so antioxidant ingredients must penetrate the skin and reach the basal layer to exert their effect. The second method is to block the transport of melanin. An important step in the formation of melanin is the transfer of mature melanosomes to keratinocytes, and melanin is deposited in the epidermis. Therefore, if the transport of melanin can be inhibited so that it cannot reach the stratum corneum of the skin, it will not cause darkening. The third method is to accelerate skin metabolism and the shedding of the stratum corneum. Acidic substances can accelerate the shedding of stratum corneum cells by softening the stratum corneum. Melanin that has reached the surface of the skin will fall off along with the stratum corneum cells. This method accelerates melanin metabolism and improves skin color.

[0004] Currently, niacinamide is commonly added to skin-whitening ingredients. Niacinamide is a B vitamin that whitens and protects the skin. Niacinamide is a water-soluble substance with an extremely small molecular weight. It can penetrate the stratum corneum and penetrate deep into the skin, inhibiting melanin deposition in the inner layers of the skin, which causes dullness and uneven skin tone. It also inhibits melanin transport, thereby promoting melanin shedding. While niacinamide has certain benefits for skin, such as retaining moisture, moisturizing, lightening melanin, and minimizing pores, the niacin in niacinamide can often cause skin allergies. This is because niacinamide undergoes hydrolysis to form niacin, which has higher pharmacological and toxic properties than niacinamide. Niacinamide can cause allergic reactions in some people after using niacinamide, manifesting as redness, itching, papules, acne, and stinging. These symptoms are more likely to occur in cold and dry climates. Traditionally, niacinamide has been controlled by controlling the amount of niacin added to minimize its side effects. However, if the amount of niacinamide added is too low, the inhibitory effect on melanin transport is not achieved, and no effective treatment has been reported. Summary of the Invention

[0005] In order to overcome the shortcomings of the existing technology, one of the purposes of the present invention is to provide a multi-channel whitening composition to solve the above-mentioned traditional technical problems. The composition controls the amount of niacinamide added and its release time through appropriate methods, so that it can better act on the whitening of the skin. At the same time, combined with the whitening principle, a multi-channel whitening control method is implemented, thereby improving skin color and producing a better whitening effect.

[0006] A second object of the present invention is to provide a method for preparing the multi-channel whitening composition.

[0007] The third object of the present invention is to provide a method for applying the multi-channel whitening composition to whitening cosmetics such as creams, lotions, gels, and facial masks.

[0008] One of the objectives of the present invention is achieved by the following technical solution:

[0009] A multi-channel whitening composition comprises the following components in parts by weight:

[0010] Melanin formation inhibitor 0.1-2 parts; melanin transport inhibitor 0.1-10 parts; melanin metabolism promoter 0.1-3 parts; other additives 10-70 parts;

[0011] The melanin transport inhibitor is composed of niacinamide, squalane, erythritol, shea butter and water in a mass ratio of (0.5-1):2:3:(1-5):(0.3-0.6).

[0012] That is, the multi-pathway whitening composition of the present invention is composed of ingredients such as a melanin formation inhibitor, a melanin transport inhibitor, and a melanin metabolism promoter. Based on the three pathways of skin darkening, a whitening raw material composition is configured from three aspects: melanin formation, melanin transport, and melanin metabolism to achieve a whitening effect. In addition, by using an oil-in-water method, niacinamide is formed into an inclusion body through ingredients such as squalane, erythritol, shea butter, and water, thereby reducing the side effects of niacinamide and being able to buffer the release of niacinamide to exert its effect.

[0013] Among them, nicotinamide, also known as 3-pyridinecarboxamide, nicotinamide, vitamin B3 or vitamin PP, is a water-soluble vitamin. The nicotinamide portion of the two coenzyme structures in the human body has reversible hydrogenation and dehydrogenation properties, playing a role in hydrogen transfer in biological oxidation, which can promote tissue respiration, biological oxidation processes and metabolism. It is of great significance to maintain the integrity of normal tissues, especially the skin, digestive tract and nervous system. Therefore, it can be used as a raw material to inhibit melanin transport in the skin. Its chemical formula is:

[0014]

[0015] Squalane is a hydrocarbon oil obtained by hydrogenating squalene extracted from the liver of deep-sea sharks. It is a hydrocarbon composed of six isoprene double bonds and belongs to a terpenoid structure. Through the action of double bonds, it can combine with the alcohol functional groups of niacinamide and erythritol through intermolecular and hydrogen bonds to form a multi-layer wrapping effect. At the same time, it has good affinity to the skin, low polarity and medium spreadability, and releases the aqueous or oily substances inside it.

[0016] Erythritol, also known as (2R,3S)-butane-1,2,3,4-tetraol, is a natural sugar alcohol (or polyol) found in fruits like grapes and pears, as well as fermented foods like soy sauce, miso, and sake. It can bind water-soluble niacinamide or nicotinamide to the alcohol functional groups of erythritol through intermolecular and hydrogen bonding, encapsulating it within the erythritol. Erythritol also penetrates the skin, effectively retaining moisture and possessing significant hydrating and water-absorbing properties. When erythritol penetrates the skin, it simultaneously releases niacinamide, which is absorbed by the skin, blocking melanin transport and protecting the skin.

[0017] Shea butter contains a large amount of triglycerides composed of saturated and unsaturated fatty acids, which can reduce the hydrolysis reaction of niacinamide in water. At the same time, it can further restore and maintain the natural elasticity of the skin and has good deep moisturizing effect.

[0018] Furthermore, the preparation of the melanin transport inhibitor includes the following preparation steps:

[0019] S1: Add nicotinamide to water and stir evenly for 0.5-1h to obtain an aqueous phase;

[0020] S2: Squalane, erythritol, and shea butter are mixed uniformly in a stirring tank for 20-40 minutes to uniformly mix the oily components to obtain an oil phase;

[0021] S3: Add the water phase to the oil phase while stirring. The water phase addition time is controlled to be completed within 1-3 minutes. Homogenize for 1 hour to 2 hours to form a stable oil-in-water emulsion.

[0022] Furthermore, the mass ratio of niacinamide, squalane, erythritol, shea butter, and water is 1:2:3:(3-5):(0.3-0.6). When a relatively large amount of niacinamide is present, a relatively stable oil-in-water emulsion is formed. After the outer oil phase substances are gradually absorbed by the skin, the niacinamide is gradually released, thereby reducing the production of niacin in the event of an excessive niacinamide dosage.

[0023] Furthermore, the melanin formation inhibitor is one or more of 4-butylresorcinol, α-arbutin, 3-o-ethylascorbic acid, and Glycyrrhiza glabra root extract.

[0024] Furthermore, the melanin formation inhibitor consists of 4-butylresorcinol, α-arbutin, 3-o-ethyl ascorbic acid, and Glycyrrhiza glabra root extract in a mass ratio of (0.1-0.6):0.2:(0.01-0.1):1.

[0025] Among them, 4-butylresorcinol is a highly effective human tyrosinase inhibitor. Before melanin is formed, it inhibits the activity of tyrosinase, thereby reducing the secretion of melanin. After melanin is formed, 4-butylresorcinol inhibits the transfer of melanin to stratum corneum cells, thereby achieving a whitening effect. In addition, 4-butylresorcinol is a small molecule compound that easily penetrates into the basal layer of the skin and has a fast action rate. At the same time, due to its strong whitening effect, it has a certain irritation to the skin and cannot be added in excess. Therefore, the present invention uses ingredients such as α-arbutin, 3-o-ethyl ascorbic acid, and Glycyrrhiza glabra root extract to achieve a mutually promoting effect, thereby achieving a better whitening effect and reducing side effects.

[0026] α-Arbutin is a naturally active substance isolated from various plant species. It contains highly hydrophilic glucose residues, which effectively retain moisture in the skin and easily penetrate the outer layer of the skin. The phenolic group is a potent inhibitor of tyrosinase, effectively inhibiting its biological activity and reducing the formation of cellular melanin, resulting in a whitening effect. Furthermore, it is highly compatible with other active ingredients at temperatures below 60°C or at low to medium temperatures. Furthermore, in the presence of the weak alkalinity of 4-butylresorcinol, its stability is controlled within the adaptive range of human skin, reducing the impact of its side effects.

[0027] 3-o-Ethyl ascorbic acid is a very useful vitamin C derivative. It is very stable in chemical properties and is a lipophilic and hydrophilic substance. It can promote the mutual solubility of other inhibitors and promoters. By inhibiting the activity of tyrosinase and dopachrome interconvertase, it blocks the formation of melanin and has a good synergistic effect with other inhibitors.

[0028] Glycyrrhiza glabra extract is derived from the stem or root of Glycyrrhiza glabra. The active ingredients are mainly triterpenes, flavonoids (glabridin), polysaccharides, amino acids, alkaloids and organic acids (glycyrrhizic acid) and other compounds. It is very stable in chemical properties. It can penetrate deep into the skin and maintain high activity, effectively inhibiting the activity of multiple enzymes (such as tyrosinase) in the process of melanin production, forming a good combination effect with other melanin formation inhibitors, further enhancing the inhibitory effect of melanin in the formation process.

[0029] Furthermore, the melanin metabolism promoter is hydroxyethylpiperazineethanesulfonic acid.

[0030] Among them, hydroxyethylpiperazine ethane sulfonic acid has certain keratin softening and whitening properties, can restructure the stratum corneum, and promote the metabolism of keratinocytes, making it an important mild exfoliating ingredient. It also provides synergistic sun protection, absorbing UV rays and some visible light, protecting the skin from UV damage. Furthermore, it is a hydrogen ion buffer that can maintain a constant pH range for a long period of time, reducing the formation of other substances caused by pH fluctuations in other ingredients, thereby reducing the side effects of other ingredients on the skin.

[0031] Furthermore, other additives include water: pH regulator: thickener: irritation soothing agent in a mass ratio of 1: (0.01-0.02): (0.1-0.3): 2.

[0032] Furthermore, the pH adjuster is citric acid or fruit acid; the thickener is one or more of polyacrylate cross-polymer-6, xanthan gum, and carbomer; and the soothing irritant is one or more of Centella asiatica extract, dipotassium glycyrrhizate, and Portulaca oleracea extract.

[0033] Furthermore, the irritation soothing agent consists of Centella asiatica extract, dipotassium glycyrrhizate, and Portulaca oleracea extract in a mass ratio of 1:(0.5-1):0.6.

[0034] Centella asiatica extract contains a variety of triterpenes, including α-amyrin. Its main components are asiaticoside and madecassoside, which help promote collagen formation in the dermis, regenerating and reconnecting fibrin, fundamentally eliminating wrinkles and leaving skin firmer and smoother.

[0035] Dipotassium glycyrrhizate is an organic compound with multiple functions such as antibacterial, anti-inflammatory, detoxification, anti-allergic, and deodorizing. It can accelerate the skin's absorption of other ingredients and enhance their effectiveness.

[0036] The flavonoids and saponins contained in purslane extract have free radical removal and antioxidant effects, which can delay skin aging.

[0037] Therefore, the present invention can promote the penetration of active ingredients into the skin by adding soothing irritants such as Centella asiatica extract, dipotassium glycyrrhizate, and Portulaca oleracea extract. On the other hand, it can also help promote the formation of collagen in the dermis, regenerate fibrin, reconnect it, and make the skin firm and smooth.

[0038] The second object of the present invention is achieved by the following technical solution:

[0039] A method for preparing a multi-channel whitening composition comprises the following steps:

[0040] S1: Mix the melanin formation inhibitor and the melanin metabolism promoter and stir them evenly for 20-40 minutes, then add the melanin transport inhibitor while stirring, and control the addition to be completed within 1-3 minutes to obtain a mixture;

[0041] S2: Add other additives to the mixture, control the pH value to 5-7, and control its stability to be within the adaptability range of human skin.

[0042] The third object of the present invention is achieved by adopting the following technical solution:

[0043] An application is characterized in that the multi-channel whitening composition is used in preparing cosmetics such as creams, lotions, gels, and facial masks.

[0044] Compared with the prior art, the present invention has the following beneficial effects:

[0045] The multi-pathway whitening composition of the present invention is composed of ingredients such as a melanin formation inhibitor, a melanin transport inhibitor, and a melanin metabolism promoter. Based on the three pathways of skin darkening, a whitening raw material composition is configured from three aspects: melanin formation, melanin transport, and melanin metabolism to achieve a whitening effect. In addition, by using an oil-in-water method, niacinamide is formed into an inclusion body using ingredients such as squalane, erythritol, shea butter, and water, thereby reducing the side effects of niacinamide and being able to buffer the release of niacinamide to exert its effect. DETAILED DESCRIPTION

[0046] The present invention will be further described below in conjunction with specific implementation methods. It should be noted that, under the premise of no conflict, the various embodiments or technical features described below can be arbitrarily combined to form new embodiments.

[0047] Example 1

[0048] A multi-channel whitening composition comprises the following components in parts by weight:

[0049] 0.1 parts of melanin formation inhibitor; 0.2 parts of melanin transport inhibitor; 2 parts of melanin metabolism promoter; 70 parts of other additives;

[0050] Among them, the melanin transport inhibitor is composed of niacinamide, squalane, erythritol, shea butter and water in a mass ratio of 0.5:2:3:2:0.6.

[0051] The preparation of the melanin transport inhibitor comprises the following steps:

[0052] S1: Add nicotinamide to water and stir evenly for 0.5 to obtain an aqueous phase;

[0053] S2: Squalane, erythritol, and shea butter were mixed uniformly in a stirring tank for 30 minutes to uniformly mix the oily components to obtain an oil phase;

[0054] S3: Add the water phase to the oil phase while stirring. The water phase addition time is controlled to be completed within 2 minutes. Homogenize for 2 hours to form a stable oil-in-water emulsion.

[0055] The melanin formation inhibitor is 4-butylresorcinol.

[0056] The melanin metabolism promoter is hydroxyethylpiperazineethane sulfonic acid.

[0057] Other additives include water: citric acid: carbomer: Centella asiatica extract in a mass ratio of 1:0.01:0.1:2.

[0058] The preparation method of the multi-channel whitening composition comprises the following preparation steps:

[0059] S1: Mix the melanin formation inhibitor and the melanin metabolism promoter and stir them evenly for 40 minutes, then add the melanin transport inhibitor while stirring, and add all of it within 3 minutes to obtain a mixture;

[0060] S2: Add other additives to the mixture, control the pH value to 5-7, and control its stability to be within the adaptability range of human skin.

[0061] Example 2

[0062] A multi-channel whitening composition comprises the following components in parts by weight:

[0063] 1 part of melanin formation inhibitor; 5 parts of melanin transport inhibitor; 0.1 part of melanin metabolism promoter; 60 parts of other additives;

[0064] Among them, the melanin transport inhibitor is composed of niacinamide, squalane, erythritol, shea butter and water in a mass ratio of 0.5:2:3:5:0.6.

[0065] The preparation of the melanin transport inhibitor comprises the following steps:

[0066] S1: Add nicotinamide to water and stir evenly for 0.5 h to obtain an aqueous phase;

[0067] S2: Squalane, erythritol, and shea butter were mixed uniformly in a stirring tank for 40 minutes to uniformly mix the oily components to obtain an oil phase;

[0068] S3: Add the water phase to the oil phase while stirring. The water phase addition time is controlled to be completed within 1 minute. Homogenize for 1 hour to form a stable oil-in-water emulsion.

[0069] The melanin formation inhibitor is Glycyrrhiza glabra root extract.

[0070] The melanin metabolism promoter is hydroxyethylpiperazineethane sulfonic acid.

[0071] Other additives include water: citric acid: carbomer: purslane extract in a mass ratio of 1:0.01:0.3:2.

[0072] The preparation method of the multi-channel whitening composition comprises the following preparation steps:

[0073] S1: Mix the melanin formation inhibitor and the melanin metabolism promoter and stir them evenly for 20 minutes, then add the melanin transport inhibitor while stirring, and add all of it within 1 minute to obtain a mixture;

[0074] S2: Add other additives to the mixture, control the pH value to 5-7, and control its stability to be within the adaptability range of human skin.

[0075] Example 3

[0076] A multi-channel whitening composition comprises the following components in parts by weight:

[0077] 2 parts of melanin formation inhibitor; 0.8 parts of melanin transport inhibitor; 2 parts of melanin metabolism promoter; 20 parts of other additives;

[0078] Among them, the melanin transport inhibitor is composed of niacinamide, squalane, erythritol, shea butter and water in a mass ratio of 0.5:2:3:2:0.3.

[0079] The preparation of the melanin transport inhibitor comprises the following steps:

[0080] S1: Add nicotinamide to water and stir evenly for 0.5 h to obtain an aqueous phase;

[0081] S2: Squalane, erythritol, and shea butter were mixed uniformly in a stirring tank for 20 minutes to uniformly mix the oily components to obtain an oil phase;

[0082] S3: Add the water phase to the oil phase while stirring. The water phase addition time is controlled to be completed within 3 minutes. Homogenize for 2 hours to form a stable oil-in-water emulsion.

[0083] The melanin formation inhibitor is α-arbutin and licorice root extract in a mass ratio of 0.2:1.

[0084] The melanin metabolism promoter is hydroxyethylpiperazineethane sulfonic acid.

[0085] Other additives include water: citric acid: carbomer: purslane extract: Centella asiatica extract in a mass ratio of 1:0.02:0.1:1:1.

[0086] The preparation method of the multi-channel whitening composition comprises the following preparation steps:

[0087] S1: Mix the melanin formation inhibitor and the melanin metabolism promoter and stir them evenly for 30 minutes, then add the melanin transport inhibitor while stirring, and control the addition to be completed within 2 minutes to obtain a mixture;

[0088] S2: Add other additives to the mixture, control the pH value to 5-7, and control its stability to be within the adaptability range of human skin.

[0089] Example 4

[0090] A multi-channel whitening composition comprises the following components in parts by weight:

[0091] 2 parts of melanin formation inhibitor; 8 parts of melanin transport inhibitor; 3 parts of melanin metabolism promoter; 70 parts of other additives;

[0092] Among them, the melanin transport inhibitor is composed of niacinamide, squalane, erythritol, shea butter and water in a mass ratio of 0.6:2:3:2:6.

[0093] The preparation of the melanin transport inhibitor comprises the following steps:

[0094] S1: Add nicotinamide to water and stir evenly for 0.8 to obtain an aqueous phase;

[0095] S2: Squalane, erythritol, and shea butter were mixed uniformly in a stirring tank for 30 min to uniformly mix the oily components to obtain an oil phase;

[0096] S3: Add the water phase to the oil phase while stirring. The water phase addition time is controlled to be completed within 1 minute. Homogenize for 2 hours to form a stable oil-in-water emulsion.

[0097] The melanin formation inhibitor consists of 4-butylresorcinol, α-arbutin, 3-o-ethyl ascorbic acid and glycyrrhiza glabra root extract in a mass ratio of 0.5:0.2:0.5:1.

[0098] The melanin metabolism promoter is hydroxyethylpiperazineethane sulfonic acid.

[0099] Other additives include water, citric acid, carbomer, and a soothing agent in a mass ratio of 1:0.01:0.2:2. The soothing agent is composed of Centella asiatica extract, dipotassium glycyrrhizate, and Portulaca oleracea extract in a mass ratio of 1:0.5:0.6.

[0100] The preparation method of the multi-channel whitening composition comprises the following preparation steps:

[0101] S1: Mix the melanin formation inhibitor and the melanin metabolism promoter and stir them evenly for 40 minutes, then add the melanin transport inhibitor while stirring, and add all of it within 2 inches to obtain a mixture;

[0102] S2: Add other additives to the mixture, control the pH value to 5-7, and control its stability to be within the adaptability range of human skin.

[0103] Comparative Example 1

[0104] The difference from Example 1 is that the melanin transport inhibitor in Comparative Example 1 is nicotinamide, and no other ingredients are compounded.

[0105] Comparative Example 2

[0106] Different from Example 1, the melanin transport inhibitor of Comparative Example 2 is composed of niacinamide, squalane, erythritol, and water in a mass ratio of 0.5:2:3:0.6, and is prepared by a water-in-oil method.

[0107] Comparative Example 3

[0108] Different from Example 1, the melanin transport inhibitor of Comparative Example 3 is composed of niacinamide, erythritol, shea butter, and water in a mass ratio of 0.5:3:2:0.6, and is prepared by a water-in-oil method.

[0109] Comparative Example 4

[0110] Different from Example 1, the melanin transport inhibitor of Comparative Example 3 is composed of niacinamide, squalane, erythritol, shea butter, and water in a mass ratio of 0.5:2:3:2:0.6, but the preparation method is simple mixing, and the oil-in-water method is not used for preparation.

[0111] Comparative Example 5

[0112] Different from Example 1, Comparative Example 5 does not contain a melanin formation inhibitor.

[0113] Comparative Example 6

[0114] Different from Example 1, Comparative Example 6 does not contain a melanin metabolism promoter.

[0115] Comparative Example 7

[0116] Different from Example 1, the soothing irritation agent of other additives in Comparative Example 7 does not contain Centella asiatica extract.

[0117] Performance Testing

[0118] The safety and whitening properties of the compositions of Examples 1 to 4 and the compositions of Comparative Examples 1 to 7 were verified. The specific verification methods are as follows:

[0119] 1. Safety experiment

[0120] A total of 110 volunteers aged 25-50 were selected and divided into 11 groups with 10 participants in each group. A 5×5 cm area was marked on the inner side of the left forearm of the volunteers and disinfected with 75% alcohol. Then, a medical cotton ball soaked in physiological saline was used to gently wipe away any residual liquid to keep the test area dry. Then, the sample was applied evenly to the test area at a rate of 1 ml each time. The skin condition was observed after 24 hours. The verification results are shown in Table 1.

[0121] Table 1

[0122]

[0123] From the above results, it can be seen that, compared with Comparative Examples 1 and 4, the compositions of Examples 1-4 of the present invention are non-irritating to human skin and do not cause allergic reactions; however, the melanin transport inhibitors of the compositions of Comparative Examples 2-3 lack a certain component, resulting in some adverse effects of the oil-in-water effect; the melanin transport inhibitors of the compositions of Comparative Examples 5-7 use an oil-in-water treatment method for niacinamide, and no other adverse reactions occur.

[0124] 2. Efficacy experiment

[0125] 110 volunteers aged between 25 and 50 with whitening needs were selected, with skin melanin content not less than 25 and skin brightness not greater than 35, with 10 people in each group; the samples were applied after cleansing every morning and evening for 14 consecutive days.

[0126] (1) Whitening effect test

[0127] The melanin content of the test skin was tested using a CK meter before and after using the composition, and the skin brightness value (L* value) of the volunteers was tested using a Danish meter before and after using the composition. The results are shown in Table 2.

[0128] Table 2

[0129]

[0130] As can be seen from the above table, the composition of the present invention can reduce skin melanin and improve skin brightness, thereby achieving the effects of freckle removal and whitening. Among them, Comparative Example 1, due to the direct use of nicotinamide, significantly reduced skin melanin after 7 days of use, but the effect after 14 days was the same as that of the embodiment of the present invention; Comparative Example 2, due to the lack of shea butter, had a slightly worse effect on skin melanin than Example 1; Comparative Example 3, due to the lack of squalane, slowed the release of the melanin transport inhibitor, and had a slightly worse effect on skin melanin than Example 1; Comparative Example 4 did not adopt the form of water-in-oil, but because it contained squalane, shea butter, and erythritol as the inhibitory component of nicotinamide, its skin melanin effect was slightly worse than Example 1; Comparative Examples 5-6 did not contain a melanin formation inhibitor or a melanin metabolism promoter, so that some pathways were not opened and the final whitening effect could not be achieved; Comparative Example 7 lacked the Centella asiatica extract, resulting in a general skin brightness effect.

[0131] (2) Anti-aging effect

[0132] The skin elasticity values ​​(Ur average) of the volunteers before and after using the composition were tested using a CK instrument. The results are shown in Table 3.

[0133] Table 3

[0134]

[0135] As can be seen from the above table, compared with comparative examples 1-7, the compositions of Examples 1-4 of the present invention can significantly improve skin elasticity.

[0136] The above embodiments are only preferred embodiments of the present invention and cannot be used to limit the scope of protection of the present invention. Any non-substantial changes and replacements made by technicians in this field on the basis of the present invention fall within the scope of protection required by the present invention.

Claims

1. A multi-channel whitening composition, characterized in that, It is composed of the following components in parts by weight: 0.1-2 parts of melanin formation inhibitor; 0.1-10 parts of melanin transport inhibitor; 0.1-3 parts of melanin metabolism promoter and 10-70 parts of other additives; The melanin transport inhibitor is composed of niacinamide, squalane, erythritol, shea butter and water in a mass ratio of (0.5-1):2:3:(1-5):(0.3-0.6); The preparation of the melanin transport inhibitor includes the following steps: S1: Add nicotinamide to water and stir evenly for 0.5-1h to obtain an aqueous phase; S2: Squalane, erythritol, and shea butter are mixed uniformly in a stirring tank for 20-40 minutes to uniformly mix the oily components to obtain an oil phase; S3: Add the water phase to the oil phase while stirring. The water phase addition time is controlled to be completed within 1-3 minutes. Homogenize for 1-2 hours to form a stable water-in-oil emulsion. The melanin formation inhibitor is one or more of 4-butylresorcinol, α-arbutin, 3-o-ethylascorbic acid, and glycyrrhiza glabra root extract; the melanin metabolism promoter is hydroxyethylpiperazineethane sulfonic acid; other additives are water, a pH regulator, a thickener, and a soothing irritant in a mass ratio of 1: (0.01-0.02): (0.1-0.3): 2; the pH regulator is citric acid or fruit acid; the thickener is one or more of polyacrylate crosspolymer-6, xanthan gum, and carbomer; the soothing irritant is one or more of Centella asiatica extract, dipotassium glycyrrhizate, and Portulaca oleracea extract; The multi-channel whitening composition comprises the following preparation steps: S1: Mix the melanin formation inhibitor and the melanin metabolism promoter and stir them evenly for 20-40 minutes, then add the melanin transport inhibitor while stirring, and control the addition to be completed within 1-3 minutes to obtain a mixture; S2: Add other additives to the mixture, control the pH value to 5-7, and control its stability to be within the adaptability range of human skin.

2. The multi-channel whitening composition according to claim 1, characterized in that The mass ratio of niacinamide, squalane, erythritol, shea butter and water is 1:2:3:(3-5):(0.3-0.6).

3. The multi-channel whitening composition according to claim 1, characterized in that The melanin formation inhibitor consists of 4-butylresorcinol, α-arbutin, 3-o-ethyl ascorbic acid and glycyrrhiza glabra root extract in a mass ratio of (0.1-0.6):0.2:(0.01-0.1):

1.

4. A method for preparing the multi-channel whitening composition according to any one of claims 1 to 3, characterized in that: The method comprises the following preparation steps: S1: Mix the melanin formation inhibitor and the melanin metabolism promoter and stir them evenly for 20-40 minutes, then add the melanin transport inhibitor while stirring, and control the addition to be completed within 1-3 minutes to obtain a mixture; S2: Add other additives to the mixture, control the pH value to 5-7, and control its stability to be within the adaptability range of human skin.

5. An application, characterized in that: The multi-channel whitening composition according to any one of claims 1 to 3 is used in preparing cosmetics such as creams, lotions, gels and facial masks.

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