An antibacterial wipe, its preparation method and application

Abstract

This invention provides an antibacterial wipe, its preparation method, and its application. The antibacterial wipe comprises an antibacterial wipe body and an antibacterial wipe impregnation solution. The antibacterial wipe body is prepared by a method comprising the following steps: dissolving modified nano-zinc oxide, then mixing it with a polymer, and electrospinning to obtain the antibacterial wipe body. The antibacterial wipe impregnation solution comprises, by weight, 0.05-0.1 parts of disinfectant, 0.002-0.05 parts of modified nano-zinc oxide, and 95-100 parts of water. The antibacterial wipe provided by this invention has good antibacterial effect, long-lasting antibacterial effect, does not require the addition of additional anti-mildew and antibacterial agents, and has low sensitization.

Description

Technical Field

[0001] This invention belongs to the field of antibacterial products, specifically relating to an antibacterial wipe, its preparation method and application, and more particularly to an antibacterial wipe with good antibacterial effect, its preparation method and application. Background Technology

[0002] As people's living standards gradually improve and their awareness of daily cleaning and disinfection increases, the demand for disinfection products is also developing from extensive to refined. A variety of antibacterial products have appeared on the market and are very popular with consumers, with a broad market prospect.

[0003] CN106491441A discloses a bactericidal and antibacterial wet wipe and its manufacturing method, comprising a non-woven fabric and an impregnating liquid. The impregnating liquid is composed of the following raw materials in the following weight ratio: 100-200 parts deionized water, 0.5-5 parts lysozyme, 5-25 parts wild chrysanthemum extract, 2-15 parts eucommia chlorogenic acid, 3-10 parts aucubin, 5-20 parts allicin, 0.05-0.3 parts potassium sorbate, 0.1-2 parts polysorbate, 0-8 parts citric acid, and 0-1 part sodium citrate. This invention can quickly remove odors and stains from tableware, fruits, and hands, while effectively sterilizing and inhibiting bacteria; it is natural and environmentally friendly, free of alcohol and fragrance, uses food-grade preservatives and emulsifiers, is safe and non-toxic, has no harmful effects on the human body, is gentle and non-irritating, and does not harm hands, possessing the advantages of high efficiency, safety, and environmental friendliness.

[0004] CN115057057A discloses a production process for antibacterial, skin-friendly, and multi-effect wet wipes, including the following process steps: S1, non-woven fabric roll cutting: The non-woven fabric roll is fixed on a feeding rack, conveyed by a conveying mechanism, and longitudinally cut into sections by a cutting machine. This invention forms a dry wet wipe substrate containing effective ingredients by impregnating the non-woven fabric with the effective ingredients and drying it. When the wet wipes need to be opened and used, the antibacterial wet wipe liquid is impregnated into the dry wet wipe substrate to form the required wet wipes. This dry-wet separation method can improve the storage time of the wet wipes when they are not in use, and can ensure that the effective ingredients inside the wet wipes can be preserved for a long time without adding a large amount of preservatives.

[0005] CN113261871A discloses an antibacterial wipe and its manufacturing method. The antibacterial wipe body includes multiple corrugated horizontal strips arranged at intervals and a connecting vertical block connecting the corrugated horizontal strips into a single unit. The corrugated horizontal strips form crests and troughs, and a cavity is formed between two adjacent corrugated horizontal strips. The connecting vertical block is provided with an arc-shaped expanded surface and multiple connecting arc-shaped bottoms connected to the arc-shaped inner surface of the arc-shaped expanded surface. The arc-shaped inner surface of the arc-shaped expanded surface matches and connects to the corresponding arc-shaped outer surface of the crest and trough, and the connecting arc-shaped bottoms match and connect to the corresponding arc-shaped inner surface of the crest and trough. This invention achieves both comfortable use and structural stability in the antibacterial wipe through the contact between the arc-shaped expanded surface and the object to be wiped, and the mutual connection between the matching arc-shaped expanded surface and the connecting arc-shaped bottoms.

[0006] The demand for sophisticated disinfection products is becoming increasingly urgent. Therefore, providing a new type of disinfection product with effective antibacterial properties has become a pressing issue. Summary of the Invention

[0007] To address the shortcomings of existing technologies, the present invention aims to provide an antibacterial wipe, its preparation method, and its application, particularly an antibacterial wipe with good antibacterial effect, its preparation method, and its application. The antibacterial wipe provided by the present invention has good and long-lasting antibacterial effect, requires no additional anti-mold and antibacterial agents, and has low allergenicity.

[0008] To achieve this objective, the present invention adopts the following technical solution:

[0009] In a first aspect, the present invention provides an antibacterial wipe, the antibacterial wipe comprising an antibacterial wipe body and an antibacterial wipe impregnation solution.

[0010] The antibacterial wipe body is prepared by a method including the following steps:

[0011] The modified nano zinc oxide is dissolved, then mixed with a polymer, and electrospun to obtain the antibacterial wipe body.

[0012] The antibacterial wipes soaking solution comprises, by weight, 0.05-0.1 parts disinfectant, 0.002-0.05 parts modified nano zinc oxide, and 95-100 parts water.

[0013] The number of parts of disinfectant can be 0.05, 0.06, 0.07, 0.08, 0.09, or 0.1, etc.; the number of parts of modified nano zinc oxide can be 0.002, 0.005, 0.01, 0.015, 0.02, 0.025, 0.03, 0.035, 0.04, 0.045, or 0.05, etc.; and the number of parts of water can be 95, 96, 97, 98, 99, or 100, etc., but are not limited to the values ​​listed above. Other unlisted values ​​within the above range are also applicable.

[0014] The method for preparing the antibacterial wipes includes the following steps: mixing the antibacterial wipe body and the antibacterial wipe impregnation solution to obtain the antibacterial wipes.

[0015] The aforementioned antibacterial wipes utilize modified nano zinc oxide, combined with other ingredients, to achieve excellent antibacterial effects and maintain their antibacterial capacity for a long time. They also do not require the addition of additional anti-mold and antibacterial agents and have low allergenicity.

[0016] Preferably, the polymer comprises any one of PLA (polylactic acid), PVA (polyvinyl alcohol), PAN (polyacrylonitrile), PMMA (polymethyl methacrylate), or PU (polyurethane).

[0017] Preferably, the modified nano-zinc oxide is prepared by a method comprising the following steps:

[0018] The modified nano zinc oxide is obtained by mixing nano zinc oxide with a modifier.

[0019] Preferably, the modifier includes any one or a combination of at least two of the following: silane coupling agent KH550, silane coupling agent KH560, polyvinylpyrrolidone, triethanolamine, di(octyl pyrophosphate) glycolate titanate, or di(octyl phosphate) titanium dioxide (ethylene glycol), and more preferably a combination of silane coupling agent KH550, polyvinylpyrrolidone, and triethanolamine.

[0020] The aforementioned specific modifiers can effectively modify the surface of nano zinc oxide, thereby improving the antibacterial effect of the product; at the same time, the use of specific modifier combinations can further enhance the antibacterial effect of the product.

[0021] Preferably, the mass ratio of the nano zinc oxide to the modifier is (1-2):(50-90), such as 1:90, 1.2:80, 1.4:70, 1.7:60 or 2:50, but not limited to the values ​​listed above. Other unlisted values ​​within the above range are also applicable.

[0022] Preferably, the disinfectant includes any one or a combination of at least two of benzalkonium bromide, benzalkonium chloride, p-chloro-meta-xylenol, polyhexamethylene biguanide hydrochloride, dialcyl dimethyl ammonium chloride, or dodecyl trimethyl ammonium chloride, such as a combination of benzalkonium bromide and benzalkonium chloride, a combination of benzalkonium chloride and p-chloro-meta-xylenol, or a combination of polyhexamethylene biguanide hydrochloride and dialcyl dimethyl ammonium chloride, etc., but is not limited to the combinations listed above, and other combinations not listed above are also applicable.

[0023] Preferably, the mass ratio of the antibacterial wipe body to the antibacterial wipe soaking liquid is 50:(0.5-1.5), such as 50:0.5, 50:0.7, 50:1, 50:1.3 or 50:1.5, but not limited to the values ​​listed above. Other values ​​not listed in the above range are also applicable.

[0024] Preferably, the antibacterial wipe soaking solution further includes 0.5-2 parts by weight of wetting agent, such as 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 part, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts, 1.5 parts, 1.6 parts, 1.7 parts, 1.8 parts, 1.9 parts, or 2 parts, but is not limited to the values ​​listed above. Other unlisted values ​​within the above range are also applicable.

[0025] Preferably, the wetting agent includes any one or a combination of at least two of glycerin, propylene glycol, Tween, Span, or polyethylene glycol, such as a combination of glycerin and propylene glycol, a combination of propylene glycol and Tween, or a combination of Tween and Span, but is not limited to the combinations listed above. Other combinations not listed above are also applicable.

[0026] Preferably, the antibacterial wipe soaking liquid further includes 0.2-2 parts by weight of thickener, such as 0.2 parts, 0.4 parts, 0.6 parts, 0.8 parts, 1 part, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts or 2 parts, but is not limited to the values ​​listed above. Other unlisted values ​​within the above range are also applicable.

[0027] Preferably, the thickener includes any one or a combination of at least two of carbomer, sodium hydroxyethyl cellulose, hydroxypropyl methylcellulose, or sodium alginate, such as a combination of carbomer and sodium hydroxyethyl cellulose, a combination of sodium hydroxyethyl cellulose and hydroxypropyl methylcellulose, or a combination of hydroxypropyl methylcellulose and sodium alginate, but is not limited to the combinations listed above. Other combinations not listed above are also applicable.

[0028] Secondly, the present invention provides a method for preparing the antibacterial wipes as described above, the method comprising the following steps: mixing the antibacterial wipe body and the antibacterial wipe impregnation solution to obtain the antibacterial wipes.

[0029] Thirdly, the present invention also provides the application of the antibacterial wipes described above in the preparation of daily antibacterial products.

[0030] Compared with the prior art, the present invention has the following beneficial effects:

[0031] This invention provides an antibacterial wipe that, by using modified nano zinc oxide in combination with other ingredients, exhibits excellent antibacterial effects and can maintain its antibacterial capacity for a long time without the need for additional anti-mildew and antibacterial agents, and has low sensitization. Specific modifiers can effectively modify the surface of nano zinc oxide, improving the antibacterial effect of the product. At the same time, the use of specific modifier combinations can further enhance the antibacterial effect of the product. Detailed Implementation

[0032] To further illustrate the technical means and effects of the present invention, the following describes the technical solution of the present invention in conjunction with preferred embodiments of the present invention. However, the present invention is not limited to the scope of the embodiments.

[0033] In the following examples, the nano zinc oxide was purchased from Yantai Luliang New Materials Technology Co., Ltd.

[0034] Silane coupling agent KH550 and silane coupling agent KH560 were purchased from Aladdin;

[0035] Polyvinylpyrrolidone was purchased from Aladdin, model K30;

[0036] Di(octyl pyrophosphate) glycolate titanate was purchased from Jiangsu Jinai Additives Co., Ltd., model KR-138S;

[0037] Di(dioctyl phosphate) titanate ethylene(ol) was purchased from Jiangsu Jinai Additives Co., Ltd., model number KR-212S.

[0038] All quantities mentioned in the following examples are by weight.

[0039] Preparation Example 1

[0040] This preparation example provides a modified nano zinc oxide, and the preparation steps are as follows:

[0041] The modified nano zinc oxide was obtained by mixing nano zinc oxide with silane coupling agent KH550, polyvinylpyrrolidone, and triethanolamine in ethanol (mass ratio 1.5:20:20:30).

[0042] Preparation Example 2

[0043] This preparation example provides a modified nano zinc oxide. The preparation steps are the same as in Preparation Example 1, except that the silane coupling agent KH550 is not included and a portion is allocated proportionally to polyvinylpyrrolidone and triethanolamine.

[0044] Preparation Example 3

[0045] This preparation example provides a modified nano zinc oxide. The preparation steps are the same as in Preparation Example 1, except that polyvinylpyrrolidone is not included and a portion is allocated proportionally to the silane coupling agent KH550 and triethanolamine.

[0046] Preparation Example 4

[0047] This preparation example provides a modified nano zinc oxide. The preparation steps are the same as in Preparation Example 1, except that it does not contain triethanolamine and the portion is reduced and allocated proportionally to polyvinylpyrrolidone and silane coupling agent KH550.

[0048] Preparation Example 5

[0049] This preparation example provides a modified nano zinc oxide. The preparation steps are the same as those in Preparation Example 1, except that the silane coupling agent KH550 and triethanolamine are not included and a portion is reduced in the allocation to polyvinylpyrrolidone.

[0050] Preparation Example 6

[0051] This preparation example provides a modified nano zinc oxide. The preparation steps are the same as in Preparation Example 1, except that polyvinylpyrrolidone and triethanolamine are not included and a portion is reduced for the silane coupling agent KH550.

[0052] Preparation Example 7

[0053] This preparation example provides a modified nano zinc oxide. The preparation steps are the same as in Preparation Example 1, except that polyvinylpyrrolidone and silane coupling agent KH550 are not included and a portion is reduced for triethanolamine.

[0054] Preparation Example 8

[0055] This preparation example provides a modified nano zinc oxide. The preparation steps are the same as in Preparation Example 1, except that the silane coupling agent KH550 is replaced with an equal amount of silane coupling agent KH560.

[0056] Preparation Example 9

[0057] This preparation example provides a modified nano zinc oxide. The preparation steps are the same as in Preparation Example 1, except that polyvinylpyrrolidone is replaced with an equal amount of di(dioctyl phosphate) titanium dioxide.

[0058] Example 1

[0059] This embodiment provides an antibacterial wipe, including an antibacterial wipe body and an antibacterial wipe soaking solution.

[0060] The preparation steps of the antibacterial wipe body are as follows: 1 part of the modified nano zinc oxide provided in Preparation Example 1 and 10 parts of PAN are dissolved in 100 parts of DMSO / H2O (9:1). The mixture is heated to 60°C in a vacuum water bath and magnetically stirred for 4 hours. The resulting crystals are washed with ethanol, then washed again with water at 50°C. After drying, the crystals are dissolved in 9 times the amount of DMF using an electromagnetic stirrer at 55°C and 60 r / min. The mixture is stirred continuously at 20°C for 24 hours to ensure homogeneity, yielding a spinning solution. Spinning is carried out at 25°C and 60% relative humidity. The spinning solution is placed in a syringe equipped with a 0.8 mm diameter needle, with the needle 18 cm from the surface of the collecting screen. The spinning solution is extruded using a pump at a rate of 2.0 mL / h, and the appropriate spinning voltage is controlled according to the actual spinning effect. The antibacterial wipe body is obtained by electrospinning.

[0061] The antibacterial wipes soaking solution comprises 0.1 parts benzalkonium bromide, 0.02 parts modified nano zinc oxide provided in Preparation Example 1, 1 part glycerin, 0.3 parts hydroxypropyl methylcellulose, and 97 parts water, which are mixed together to obtain the solution.

[0062] The method for preparing the antibacterial wipes is as follows: the antibacterial wipe body is immersed in an antibacterial wipe soaking solution, and the antibacterial wipes are obtained after the antibacterial wipe soaking solution is completely absorbed.

[0063] Example 2

[0064] This embodiment provides an antibacterial wipe, including an antibacterial wipe body and an antibacterial wipe soaking solution.

[0065] The steps for preparing the antibacterial wipe body are as follows: 100 parts of the modified nano zinc oxide provided in Preparation Example 1 are dissolved in 100 parts of DMF, and then mixed and stirred with 100 parts of PU to obtain an electrospinning solution, and then the antibacterial wipe body is obtained by electrospinning.

[0066] The antibacterial wipes soaking solution comprises 0.05 parts benzalkonium chloride, 0.002 parts modified nano zinc oxide provided in Preparation Example 1, 0.5 parts propylene glycol, 0.2 parts carbomer, and 95 parts water, which are mixed together to obtain the solution.

[0067] The method for preparing the antibacterial wipes is as follows: the antibacterial wipe body is immersed in an antibacterial wipe soaking solution, and the antibacterial wipes are obtained after the antibacterial wipe soaking solution is completely absorbed.

[0068] Example 3

[0069] This embodiment provides an antibacterial wipe, including an antibacterial wipe body and an antibacterial wipe soaking solution.

[0070] The steps for preparing the antibacterial wipe body are as follows: 100 parts of the modified nano zinc oxide provided in Preparation Example 1 are dissolved in 100 parts of DMF, and then mixed and stirred with 100 parts of PLA to obtain an electrospinning solution, and then the antibacterial wipe body is obtained by electrospinning.

[0071] The antibacterial wipes soaking solution comprises 0.1 parts of p-chloro-meta-xylenol, 0.05 parts of modified nano zinc oxide provided in Preparation Example 1, 2 parts of glycerin, 2 parts of sodium alginate, and 100 parts of water, which are prepared by mixing the components.

[0072] The method for preparing the antibacterial wipes is as follows: the antibacterial wipe body is immersed in an antibacterial wipe soaking solution, and the antibacterial wipes are obtained after the antibacterial wipe soaking solution is completely absorbed.

[0073] Example 4-11

[0074] Examples 4-11 each provide an antibacterial wipe. The preparation method is the same as in Example 1, except that the modified nano zinc oxide provided in Preparation Example 1 is replaced with an equal amount of the modified nano zinc oxide provided in Preparation Examples 2-9.

[0075] Comparative Example 1

[0076] This comparative example provides an antibacterial wipe. The preparation method is the same as in Example 1, except that the modified nano zinc oxide in the preparation step of the antibacterial wipe body is replaced with an equal amount of nano zinc oxide.

[0077] Comparative Example 2

[0078] This comparative example provides an antibacterial wipe. The preparation method is the same as in Example 1, except that the modified nano zinc oxide in the antibacterial wipe soaking solution is replaced with an equal amount of nano zinc oxide.

[0079] Comparative Example 3

[0080] This comparative example provides an antibacterial wipe. The preparation method is the same as in Example 1, except that the modified nano zinc oxide in the preparation step of the antibacterial wipe body is replaced with an equal amount of nano zinc oxide, and the modified nano zinc oxide in the antibacterial wipe soaking solution is replaced with an equal amount of nano zinc oxide.

[0081] Effect test:

[0082] The antibacterial effects of the antibacterial wipes provided in Examples 1-11 and Comparative Examples 1-3 were tested using the inhibition zone test, and the test method is as follows:

[0083] (1) The antibacterial wipes were made into round pieces with a diameter of 5 mm and a thickness of no more than 4 mm as test samples, with 4 wipes per group.

[0084] (2) Inoculation of test bacteria: Use a sterile cotton swab to collect a concentration of 5×10⁻⁶ bacteria.5 CFU / mL 5×10 6 A CFU / mL suspension of the test bacteria (Escherichia coli) was evenly spread three times on the surface of a nutrient agar plate. After each spread, the plate was rotated 60°, and finally, a cotton swab was used to swab around the edge of the plate. The plate was then covered and incubated at 20°C for 5 minutes to dry.

[0085] (3) Placement of Antibacterial Samples: For each test, place 4 test samples on one contaminated plate. Use sterile forceps to place the sample pieces onto the plate surface. The center of each sample piece should be at least 25 mm apart, and the sample piece should be at least 15 mm away from the periphery of the plate. After placement, gently press the sample piece with sterile forceps to ensure it adheres tightly to the plate surface. Cover the plate and incubate at 37℃ for 18 hours to observe the results. Measure and record the diameter of the inhibition zone (including the sample piece) using calipers. Repeat the test 3 times. The diameter measurement is based on the outer edge of the inhibition zone. An inhibition zone diameter greater than 7 mm is considered to have antibacterial effect. An inhibition zone diameter less than or equal to 7 mm is considered to have no antibacterial effect.

[0086] The results are as follows:

[0087]

[0088]

[0089] The above data show that the antibacterial wipes provided by the present invention have excellent antibacterial effects; comparing Example 1 and Comparative Examples 1-3, it can be found that the present invention can significantly improve the antibacterial effect of the product by using specific modified nano zinc oxide; comparing Examples 1 and 4-9, it can be found that the present invention significantly improves the antibacterial effect of the product by using a combination of silane coupling agent KH550, polyvinylpyrrolidone and triethanolamine, which have a synergistic effect; comparing Examples 1 and 10-11, it can be found that the present invention can effectively improve the antibacterial effect of the product compared with other modifiers by selecting specific modifiers.

[0090] The applicant declares that the above embodiments illustrate the antibacterial wipes, their preparation method, and applications, but the present invention is not limited to the above embodiments, i.e., it does not mean that the present invention must rely on the above embodiments to be implemented. Those skilled in the art should understand that any improvements to the present invention, equivalent substitutions of the raw materials of the product, addition of auxiliary components, and selection of specific methods, etc., all fall within the protection and disclosure scope of the present invention.

[0091] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the scope of the technical concept of the present invention, various simple modifications can be made to the technical solution of the present invention, and these simple modifications all fall within the protection scope of the present invention.

[0092] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not describe the various possible combinations separately.

Claims

1. An antibacterial wipe, characterized in that, The antibacterial wipes include an antibacterial wipe body and an antibacterial wipe soaking solution; The antibacterial wipe body is prepared by a method including the following steps: Modified nano zinc oxide is dissolved, then mixed with a polymer, and electrospun to obtain the antibacterial wipe body; the polymer includes any one of PLA, PVA, PAN, PMMA or PU; The modified nano zinc oxide is prepared by a method comprising the following steps: mixing nano zinc oxide with a modifier to obtain the modified nano zinc oxide; The mass ratio of the nano zinc oxide to the modifier is (1-2):(50-90); The modifier is a combination of silane coupling agent KH550, polyvinylpyrrolidone, and triethanolamine; The antibacterial wipes soaking solution comprises, by weight, 0.05-0.1 parts disinfectant, 0.002-0.05 parts modified nano zinc oxide, and 95-100 parts water; The disinfectant includes any one or a combination of at least two of the following: benzalkonium bromide, benzalkonium chloride, p-chloro-meta-xylenol, polyhexamethylene biguanide hydrochloride, decyl dimethyl ammonium chloride, or dodecyl trimethyl ammonium chloride; The mass ratio of the antibacterial wipe body to the antibacterial wipe soaking liquid is 50:(0.5-1.5).

2. The antibacterial wipes according to claim 1, characterized in that, The antibacterial wipes soaking solution also includes 0.5-2 parts of wetting agent by weight.

3. The antibacterial wipes according to claim 2, characterized in that, The wetting agent includes any one or a combination of at least two of glycerin, propylene glycol, Tween, Span, or polyethylene glycol.

4. The antibacterial wipes according to claim 1, characterized in that, The antibacterial wipes soaking solution also includes 0.2-2 parts by weight of thickener.

5. The antibacterial wipes according to claim 4, characterized in that, The thickener includes any one or a combination of at least two of carbomer, sodium hydroxyethyl cellulose, hydroxypropyl methylcellulose, or sodium alginate.

6. A method for preparing antibacterial wipes according to any one of claims 1-5, characterized in that, The preparation method includes the following steps: mixing the antibacterial wipe body and the antibacterial wipe soaking liquid to obtain the antibacterial wipe.

7. The use of an antibacterial wipe according to any one of claims 1-5 in the preparation of daily antibacterial products.

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