No-rinse disinfectant and method of making same

Abstract

This invention relates to the field of hand hygiene cleaning and disinfection technology. An embodiment of this invention discloses a rinse-free disinfectant and its preparation method. The rinse-free disinfectant comprises octinidin hydrochloride, ethanol, and a solvent. The mass percentage of octinidin hydrochloride in the rinse-free disinfectant is 0.1%-0.3%, and the mass percentage of ethanol in the rinse-free disinfectant is 50-60%. After use, it can effectively kill Gram-negative bacilli and Gram-positive bacteria on the hands, exhibiting significant disinfection and sterilization effects, as well as long-lasting antibacterial effects, with mild efficacy and stable performance.

Description

Technical Field

[0001] This invention relates to the field of hand hygiene cleaning and disinfection technology, and in particular to a no-rinse disinfectant and its preparation method. Background Technology

[0002] Hospital-acquired infections (HAIs), also known as hospital-acquired infections, refer to infections acquired by hospitalized patients within a hospital, including infections occurring during hospitalization and post-discharge infections acquired within the hospital. Epidemiological studies show that 90% of hospital-acquired infections today are caused by contact transmission, with infections caused by pathogens carried by healthcare workers' hands accounting for 30% of hospital-acquired infections. Hand hygiene, which refers to any method that removes or destroys microorganisms on the skin, including handwashing, hygienic hand disinfection, and surgical hand disinfection, is a key step in preventing the spread of disease through hand contact among healthcare workers.

[0003] No-rinse surgical hand sanitizers are a new type of disinfectant that has emerged in recent years. Although these products currently have many names in clinical use, such as no-rinse surgical hand sanitizer gel and universal surgical hand sanitizer solution, the main components of the disinfectant are still chlorhexidine and ethanol, supplemented with skin protectants.

[0004] Currently, the main ingredient in surgical hand sanitizer gels with long-lasting antibacterial properties is chlorhexidine. However, chlorhexidine has certain irritant and sensitizing properties. Therefore, the need to develop a milder disinfectant agent with long-lasting antibacterial properties for surgical hand sanitizers has been put on the agenda. Summary of the Invention

[0005] This invention aims to solve at least one of the technical problems existing in the prior art. To this end, this invention proposes a hand sanitizer and its preparation method to achieve a gentle yet long-lasting antibacterial effect.

[0006] In a first aspect, the present invention provides a hand sanitizer comprising octinididine hydrochloride, ethanol, and a solvent; wherein the mass percentage of octinididine hydrochloride in the hand sanitizer is 0.1%-0.3%, and the mass percentage of ethanol in the hand sanitizer is 50%-60%.

[0007] According to some embodiments of this application, the mass percentage of oxytinididine hydrochloride in the hand sanitizer is 0.2%-0.3%.

[0008] According to some embodiments of this application, the ethanol accounts for 58%-60% of the mass of the hand sanitizer.

[0009] According to some embodiments of this application, the solvent is water, and the solvent accounts for 32.7%-33.75% of the mass of the hand sanitizer.

[0010] According to some embodiments of this application, the hand sanitizer further includes an emulsifier selected from at least one of hexadecyl palmitate and isopropyl myristate.

[0011] According to some embodiments of this application, the hand sanitizer further includes a solubilizer, which is behenyl alcohol polyether-10.

[0012] According to some embodiments of this application, the hand sanitizer further includes a thickener selected from at least one of docosahexaenoic acid, polyethylene glycol-200, polyethylene glycol-400, and polyethylene glycol-600.

[0013] According to some embodiments of this application, the hand sanitizer further includes a skin care agent selected from at least one of glycerin, squalane, jojoba oil, methyl gluceth-20, hydrolyzed corn gluten, bisabolol, and ginger root extract.

[0014] According to some embodiments of this application, the hand sanitizer further includes a lubricant, wherein the lubricant is dimethyl silicone oil.

[0015] In a second aspect, the present invention provides a method for preparing a hand sanitizer as described in any one of the first aspects, the method comprising:

[0016] A uniformly mixed solvent and ethanol are used to obtain an intermediate mixture;

[0017] Add oxytinidin hydrochloride to the intermediate mixture and stir until dissolved to obtain a hand sanitizer.

[0018] The above-described one or more embodiments of the present invention have at least one or more of the following beneficial effects: after use, it can effectively eliminate Gram-negative bacilli, Gram-positive bacteria, etc. on the hands, with significant disinfection and sterilization effects, and has long-lasting antibacterial effects, with mild effects and stable performance.

[0019] Additional aspects and advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Detailed Implementation

[0020] To make the above-mentioned objectives, features, and advantages of this application more apparent and understandable, the specific embodiments of this application are described in detail below. Many specific details are set forth in the following description to provide a thorough understanding of this application. However, this application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar modifications without departing from the spirit of this application. Therefore, this application is not limited to the specific embodiments disclosed below.

[0021] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. The terms “comprising” or “including” and similar terms used herein mean that an element or object preceding the word encompasses the elements or objects listed following the word and their equivalents, without excluding other elements or objects. The terms “and / or” or “and / or” as used herein include any and all combinations of one or more of the associated listed items.

[0022] As described in the background section, current surgical hand sanitizers based on chlorhexidine not only provide immediate disinfection and sterilization but also offer long-lasting antibacterial properties. However, the long-lasting antibacterial effect of chlorhexidine in clinical applications is concentration-dependent; higher concentrations are required to achieve prolonged antibacterial effects, resulting in higher costs. Furthermore, chlorhexidine is somewhat irritating and may cause allergic reactions on the skin. If chlorhexidine accidentally comes into contact with the eyes, it may damage the cornea or even lead to blindness.

[0023] To address the aforementioned issues, this application creatively proposes a no-rinse disinfectant and its preparation method, which combines oxytinididine hydrochloride and ethanol as bactericides, resulting in good bactericidal effect, long-lasting antibacterial effect, and gentle, non-irritating properties.

[0024] The following describes some preferred embodiments of this application. It should be noted that the following description is for illustrative purposes only and is not intended to limit the scope of protection of this application. The steps involved in this application may be performed precisely in sequence, or various steps may be processed in reverse order or simultaneously. Furthermore, other operations may be added to these processes, or one or more steps may be removed from these processes.

[0025] This application discloses a no-rinse disinfectant, which includes ostinidine hydrochloride, ethanol, and a solvent; wherein the mass percentage of ostinidine hydrochloride in the no-rinse disinfectant is 0.1%-0.3%, and the mass percentage of ethanol in the no-rinse disinfectant is 58%-60%.

[0026] Otinididine hydrochloride, also known as otinididine dihydrochloride, poses no threat to human health in terms of acute, subchronic, and chronic toxicity, carcinogenicity, reproductive effects, human irritation, and allergenicity. Furthermore, otinididine hydrochloride exhibits good tissue compatibility, a broad antibacterial spectrum, rapid and sustained action, and good thermal stability, making it advantageous for the local treatment of microbial infections. Ethanol also possesses disinfectant properties; it has strong penetrating and bactericidal capabilities, capable of disrupting the cell walls of pathogenic bacteria, denaturing bacterial proteins, and thus killing bacteria to achieve a disinfection effect. The hand sanitizer disclosed in this application combines volatile ethanol with otinididine hydrochloride, which has a strong residual effect on the skin surface. This combination achieves both immediate and highly effective disinfection and long-lasting antibacterial properties. Compared to chlorhexidine-based surgical hand sanitizers, the hand sanitizer provided in this application offers superior antibacterial efficacy, lower cost, and lower irritation and sensitization.

[0027] In this application, the term "ethanol" refers to anhydrous ethanol with a volume fraction of 99.5% or higher, and optionally or preferably, "ethanol" refers to analytical grade anhydrous ethanol with an ethanol content of ≥99.7%.

[0028] For example, the mass percentage of octinididine hydrochloride in the hand sanitizer can be 0.1%, 0.12%, 0.15%, 0.17%, 0.19%, 0.2%, 0.22%, 0.25%, 0.26%, 0.28%, 0.3%, or any value within the above range. The mass percentage of ethanol in the hand sanitizer can be 50%, 52%, 54%, 55%, 57%, 58%, 59%, 60%, or any value within the above range.

[0029] Optionally or preferably, the mass percentage of ostinidine hydrochloride in the hand sanitizer is 0.2%-0.3%. Too low a concentration of ostinidine hydrochloride will not meet the requirements for long-lasting antibacterial effects, while too high a concentration will result in material waste and unnecessary costs. For example, the mass percentage of ostinidine hydrochloride in the hand sanitizer can be 0.2%, 0.21%, 0.22%, 0.23%, 0.25%, 0.26%, 0.27%, 0.28%, 0.29%, or 0.3%.

[0030] Preferably, the mass percentage of ethanol in the hand sanitizer is 58%-60%, which can be 58.1%, 58.3%, 58.6%, 58.8%, 59%, 59.3%, 59.5%, 59.7%, 59.9%, or any value within the above range. If the ethanol content is too low, the immediate sterilization effect is poor, and because ethanol also acts as a solvent, a low ethanol content reduces the solubility of oteninidine hydrochloride, making it prone to precipitation.

[0031] In some embodiments, the solvent is water, and the solvent accounts for 32.7%-33.75% of the alcohol-based hand sanitizer by mass. For example, the solvent's mass percentage in the hand sanitizer can be 32.7%, 32.81%, 32.85%, 32.9%, 32.93%, 32.97%, 33.1%, 33.25%, 33.5%, 33.57%, 33.6%, 33.66%, 33.7%, 33.75%, or any value within the above range.

[0032] In some embodiments, the hand sanitizer also includes an emulsifier selected from at least one of hexadecyl palmitate and isopropyl myristate.

[0033] The term "emulsifier" refers to a substance that enables a mixture of two or more immiscible components to form a stable emulsion. It is a type of surfactant that improves the surface tension between the various constituent phases in a system, forming a uniform dispersion or emulsion. In this application, the emulsifier uniformly disperses oxytinididine hydrochloride and ethanol in water. The selected hexadecyl palmitate and isopropyl myristate emulsifiers, in addition to their emulsifying effect, also possess certain thickening and moisturizing properties, improving the skin feel of the hand sanitizer.

[0034] In some embodiments, the hand sanitizer also includes a solubilizer, which is behenyl alcohol polyether-10.

[0035] The solubilizer increases the solubility of octinididine hydrochloride and forms a clear solution in the presence of emulsifier colloidal particles in the hand sanitizer.

[0036] In some embodiments, the hand sanitizer also includes a thickener selected from at least one of docosahexaenoic acid, polyethylene glycol-200, polyethylene glycol-400, and polyethylene glycol-600.

[0037] The term "polyethylene glycol" refers to Polyethylene Glycol, abbreviated as PEG, a multifunctional polymer with different molecular weight grades. PEG-200 refers to polyethylene glycol with an average molecular weight of 200 g / mol, PEG-400 refers to PEG with an average molecular weight of 400 g / mol, and PEG-600 refers to PEG with an average molecular weight of 600 g / mol. The higher the molecular weight, the higher the viscosity and solubility of the polyethylene glycol.

[0038] Thickeners, also known as gelling agents, increase the viscosity of hand sanitizers to ultimately form a hand sanitizer gel, thus keeping the hand sanitizer system uniform and stable.

[0039] In some embodiments, the hand sanitizer also includes a skin care agent selected from at least one of glycerin, squalane, jojoba oil, methyl gluceth-20, hydrolyzed corn gluten, bisabolol, and ginger root extract.

[0040] The above-mentioned skin care products have high moisturizing and hydrating properties, which can maintain skin moisture and relieve skin dryness caused by the evaporation of ethanol on the skin surface after washing hands with hand sanitizer.

[0041] In some embodiments, the hand sanitizer also includes a lubricant, said lubricant being dimethyl silicone oil.

[0042] Dimethyl silicone oil, also known as polydimethylsiloxane, has anti-foaming, defoaming, and anti-spraying properties when applied with appropriate viscosity, preventing a "whitening" effect when applying hand sanitizer. High-viscosity dimethyl silicone oil is more oily, while low-viscosity dimethyl silicone oil provides a dry feeling to the skin.

[0043] In some embodiments, other additives such as pH adjusters, humectants, defoamers, fragrances, or additives that achieve other functions may be used to participate in the composition of the hand sanitizer.

[0044] This application also discloses a method for preparing the above-mentioned hand sanitizer. The preparation method may include the following exemplary steps:

[0045] The first step is to uniformly mix the solvent and ethanol to obtain an intermediate mixture.

[0046] In some embodiments, the solvent and ethanol are mixed uniformly by stirring.

[0047] Optionally or preferably, when the hand sanitizer contains emulsifiers, solubilizers, thickeners, skin care agents, and lubricants, the solvent is first heated to 50-55°C to dissolve the emulsifiers, solubilizers, and thickeners into the solvent. Then, oil-soluble skin care agents and lubricants are added, heated to 87-90°C, homogenized, and stirred until dissolved. Finally, ethanol is added and stirred until dissolved to form a homogeneous intermediate mixture system.

[0048] The second step is to add oxytinididine hydrochloride to the intermediate mixture and stir until dissolved to obtain a hand sanitizer.

[0049] In some embodiments, a water-soluble skin care agent and oxytinididine hydrochloride are added to the intermediate mixture system, stirred until dissolved, and stirred at a low speed for 5-15 minutes.

[0050] The present application will be further described in detail below with reference to embodiments. It should be noted that the following embodiments are for illustrative purposes only and are not intended to limit the scope of protection claimed in this application.

[0051] Example 1: In this example, the no-rinse disinfectant comprises 0.05% emulsifier, 0.8% solubilizer, 1.8% thickener, 3.3% skin care agent, 0.2% lubricant, 58% ethanol, 0.1% oxytinididine hydrochloride, and 35.75% water by weight. The preparation method of the no-rinse disinfectant is as follows:

[0052] Add 35.75g of purified water to the mixing pot, start stirring, and turn on the heat. When the temperature reaches about 50℃, add 0.05g of palmitate hexadecyl ester, 0.8g of behenyl alcohol polyether-10, 0.8g of dodecyl alcohol, 0.5g of polyethylene glycol-200, 0.5g of polyethylene glycol-600, and 0.5g of glycerin, and stir until dissolved. Continue heating while adding 1g of squalane and 0.2g of dimethyl silicone oil in sequence, and heat to 87-90℃. Stir for 45 minutes and homogenize at 1300 rpm for 5 minutes. Then add 58g of alcohol to the mixing pot and stir for 10 minutes until fully dissolved. Then add the heat-sensitive ingredients 1g of nicotinamide, 0.6g of methyl gluceth-20, 0.2g of hydrolyzed corn gluten, and 0.1g of oxytetracycline hydrochloride, and homogenize at 1600-1700 rpm for 5 minutes.

[0053] Example 2: In this example, the hand sanitizer comprises 0.08% by weight of emulsifier, 0.9% by weight of solubilizer, 1.9% by weight of thickener, 3.4% by weight of skin care agent, 0.3% by weight of lubricant, 59% by weight of ethanol, 0.2% by weight of oxytinididine hydrochloride, and 34.22% by weight of water. Its preparation method is as follows:

[0054] Add 34.22g of purified water to the mixing pot, start stirring, and turn on the heat. When the temperature reaches about 50℃, add 0.08g of palmitate hexadecyl ester, 0.9g of behenyl alcohol polyether-10, 0.9g of dodecyl alcohol, 0.5g of polyethylene glycol-400, 0.5g of polyethylene glycol, and 0.5g of glycerin, and stir until dissolved. Continue heating while adding 1g of squalane and 0.3g of dimethyl silicone oil in sequence, and heat to 87-90℃, stirring for 45 minutes, and homogenizing at 1300 rpm for 5 minutes. Then add 59g of alcohol to the mixing pot and stir for 10 minutes until fully dissolved. Then add the heat-sensitive raw materials 1g of nicotinamide, 0.6g of methyl gluceth-20, 0.3g of bisabolol, and 0.2g of oxytetracycline hydrochloride, and homogenize at 1600-1700 rpm for 5 minutes.

[0055] Example 3: In this example, the no-rinse disinfectant comprises: 0.1% emulsifier, 1.0% solubilizer, 2.0% thickener, 3.5% skin care agent, 0.4% lubricant, 60% ethanol, 0.3% oxytinididine hydrochloride, and 32.7% water by weight. The preparation method of the no-rinse disinfectant is as follows:

[0056] Add 32.7g of purified water to the mixing pot, start stirring, and turn on the heat. When the temperature reaches about 50℃, add 0.1g of hexadecyl palmitate, 1.0g of behenyl alcohol polyether-10, 1.0g of dodecyl alcohol, 0.5g of polyethylene glycol-200, 0.5g of polyethylene glycol-600, and 0.3g of glycerin, and stir until dissolved. Continue heating while adding 1g of jojoba oil and 0.4g of dimethyl silicone oil in sequence, and heat to 87-90℃. Stir for 45 minutes and homogenize at 1300 rpm for 5 minutes. Then add 60g of alcohol to the mixing pot and stir for 10 minutes until fully dissolved. Then add the heat-sensitive ingredients 1.2g of nicotinamide, 0.8g of methyl gluceth-20, 0.2g of hydrolyzed corn gluten, and 0.3g of oxytetracycline hydrochloride, and homogenize at 1600-1700 rpm for 5 minutes.

[0057] Example 4: In this comparative example, the hand sanitizer comprises 0.08% by weight of emulsifier, 0.9% by weight of solubilizer, 1.9% by weight of thickener, 3.4% by weight of skin care agent, 0.3% by weight of lubricant, 50% by weight of ethanol, 0.1% by weight of oxytinididine hydrochloride, and 43.32% by weight of water. Its preparation method is as follows:

[0058] Add 43.32g of purified water to the mixing pot, start stirring, and turn on the heat. When the temperature reaches about 50℃, add 0.08g of hexadecyl palmitate, 0.9g of behenyl alcohol polyether-10, 0.9g of dodecyl alcohol, 0.5g of polyethylene glycol-400, 0.5g of polyethylene glycol, and 0.5g of glycerin, and stir until dissolved. Continue heating while adding 1g of squalane and 0.3g of dimethyl silicone oil in sequence, heat to 87-90℃, stir for 45 minutes, and homogenize at 1300 rpm for 5 minutes. Then add 50g of alcohol to the mixing pot and stir for 10 minutes until fully dissolved. Then add the heat-sensitive raw materials 1g of nicotinamide, 0.6g of methyl gluceth-20, 0.3g of bisabolol, and 0.1g of oxytetracycline hydrochloride, and homogenize at 1600-1700 rpm for 5 minutes.

[0059] Comparative Example 1: In this comparative example, the no-rinse disinfectant comprises 0.05% emulsifier, 0.8% solubilizer, 1.8% thickener, 3.3% skin care agent, 0.2% lubricant, 60% ethanol, 0.05% oxytinididine hydrochloride, and 33.80% water by mass. The preparation method of the no-rinse disinfectant is as follows:

[0060] Add 33.80g of purified water to the mixing pot, start stirring, and turn on the heat. When the temperature reaches about 50℃, add 0.05g of palmitate hexadecyl ester, 0.8g of behenyl alcohol polyether-10, 0.8g of dodecyl alcohol, 0.5g of polyethylene glycol-200, 0.5g of polyethylene glycol-600, and 0.5g of glycerin, and stir until dissolved. Continue heating while adding 1g of squalane and 0.2g of dimethyl silicone oil, and heat to 87-90℃. Stir for 45 minutes and homogenize at 1300 rpm for 5 minutes. Then add 60g of alcohol to the mixing pot and stir for 10 minutes until fully dissolved. Then add the heat-sensitive ingredients 1g of nicotinamide, 0.6g of methyl gluceth-20, 0.2g of hydrolyzed corn gluten, and 0.05g of oxytetracycline hydrochloride, and homogenize at 1600-1700 rpm for 5 minutes.

[0061] Comparative Example 2: In this comparative example, the no-rinse disinfectant comprises 0.05% emulsifier, 0.8% solubilizer, 1.8% thickener, 3.3% skin care agent, 0.2% lubricant, 60% ethanol, 0.4% oxytinididine hydrochloride, and 33.45% water by mass. The preparation method of the no-rinse disinfectant is as follows:

[0062] Add 33.45g of purified water to the mixing pot, start stirring, and turn on the heat. When the temperature reaches about 50℃, add 0.05g of hexadecyl palmitate, 0.8g of behenyl alcohol polyether-10, 0.8g of dodecyl alcohol, 0.5g of polyethylene glycol-200, 0.5g of polyethylene glycol-600, and 0.5g of glycerin, and stir until dissolved. Continue heating while adding 1g of squalane and 0.2g of dimethyl silicone oil, and heat to 87-90℃. Stir for 45 minutes and homogenize at 1300 rpm for 5 minutes. Then add 60g of alcohol to the mixing pot and stir for 10 minutes until fully dissolved. Then add the heat-sensitive ingredients 1g of nicotinamide, 0.6g of methyl gluceth-20, 0.2g of hydrolyzed corn gluten, and 0.4g of oxytetracycline hydrochloride, and homogenize at 1600-1700 rpm for 5 minutes.

[0063] Comparative Example 3: In this comparative example, the hand sanitizer comprises 0.08% by weight of emulsifier, 0.9% by weight of solubilizer, 1.9% by weight of thickener, 3.4% by weight of skin care agent, 0.3% by weight of lubricant, 65% by weight of ethanol, 0.1% by weight of oxytinididine hydrochloride, and 28.32% by weight of water. Its preparation method is as follows:

[0064] Add 28.32g of purified water to the mixing pot, start stirring, and turn on the heat. When the temperature reaches about 50℃, add 0.08g of hexadecyl palmitate, 0.9g of behenyl alcohol polyether-10, 0.9g of docosyl alcohol, 0.5g of polyethylene glycol-400, 0.5g of polyethylene glycol, and 0.5g of glycerin, and stir until dissolved. Continue heating while adding 1g of squalane and 0.3g of dimethyl silicone oil in sequence, and heat to 87-90℃, stirring for 45 minutes, and homogenizing at 1300 rpm for 5 minutes. Then add 65g of alcohol to the mixing pot and stir for 10 minutes until fully dissolved. Then add the heat-sensitive raw materials 1g of nicotinamide, 0.6g of methyl gluceth-20, 0.3g of bisabolol, and 0.1g of oxytetracycline hydrochloride, and homogenize at 1600-1700 rpm for 5 minutes.

[0065] Comparative Example 4: In this comparative example, the no-rinse disinfectant comprises 0.05% emulsifier, 0.8% solubilizer, 1.8% thickener, 3.3% skin care agent, 0.2% lubricant, 40% ethanol, 0.1% oxytinididine hydrochloride, and 53.75% water by mass. The preparation method of the no-rinse disinfectant is as follows:

[0066] Add 53.75g of purified water to the mixing pot, start stirring, and turn on the heat. When the temperature reaches about 50℃, add 0.05g of palmitate hexadecyl ester, 0.8g of behenyl alcohol polyether-10, 0.8g of dodecyl alcohol, 0.5g of polyethylene glycol-200, 0.5g of polyethylene glycol-600, and 0.5g of glycerin, and stir until dissolved. Continue heating while adding 1g of squalane and 0.2g of dimethyl silicone oil, and heat to 87-90℃. Stir for 45 minutes and homogenize at 1300 rpm for 5 minutes. Then add 40g of alcohol to the mixing pot and stir for 10 minutes until fully dissolved. Then add the heat-sensitive ingredients 1g of nicotinamide, 0.6g of methyl gluceth-20, 0.2g of hydrolyzed corn gluten, and 0.1g of oxytetracycline hydrochloride, and homogenize at 1600-1700 rpm for 5 minutes.

[0067] Stability Test: Samples of the same mass as those prepared in the above examples and comparative examples of the no-rinse disinfectant were subjected to accelerated aging tests at 54°C for 14 days and at 37°C for 3 months. No significant changes were observed in the product's appearance, pH value, or other physicochemical indicators, and all indicators remained within the COA range. Referring to section 2.2.3 of the "Disinfection Technical Specifications 2002 Edition" for the stability determination of disinfectant products, the product's shelf life was defined as 24 months. Specific test results are shown in Table 1.

[0068] Table 1

[0069]

[0070]

[0071] 2. Microbial testing

[0072] 2.1 Initial bactericidal performance

[0073] The sterilization test was conducted according to the carrier immersion sterilization test procedure in section 2.1.1.7.5 of the "Disinfection Technical Specifications 2002 Edition". The specific test results are shown in Table 2.

[0074] Table 2

[0075]

[0076]

[0077]

[0078] 2.2 Long-lasting antibacterial test

[0079] Refer to section 5.2.7 of the "Evaluation Methods for Antibacterial and Bacteriostatic Effects" (WS / T 650-2019) for the sustained antibacterial test. Specific test results are shown in Table 3.

[0080] Table 3

[0081]

[0082]

[0083] Among them, AiHuJia 9200 is a 1.1% chlorhexidine gluconate surgical hand sanitizer gel.

[0084] Referring to Table 1, the changes in the content of octinididine hydrochloride and ethanol in the hand sanitizers provided in Examples 1-4 and Comparative Examples 1-4 were all within ±10%, which met the stability requirements of the disinfection technical specifications.

[0085] Referring to Tables 2 and 3, the disinfection and long-lasting antibacterial effects of the hand sanitizers provided in Examples 1-4 are all qualified, and the 6-hour long-lasting antibacterial effect is better than that of the 1.1% chlorhexidine gluconate surgical hand sanitizer gel in the prior art.

[0086] Referring to Tables 2 and 3, although the disinfection and long-lasting antibacterial effects of the hand sanitizers provided in Comparative Examples 1-4 were satisfactory, the disinfection and long-lasting antibacterial effects of the hand sanitizers provided in Comparative Examples 1 and 4 were significantly inferior. Their 6-hour long-lasting antibacterial effect was not as good as that of the 1.1% chlorhexidine gluconate surgical hand sanitizer gel. While the disinfection and long-lasting antibacterial effects of the hand sanitizers provided in Comparative Examples 2 and 3 were excellent, they showed relatively high skin irritation in tests. Furthermore, the hand sanitizer provided in Comparative Example 2, despite the high cost due to the high concentration of octinidin hydrochloride, did not show a significant improvement in disinfection and long-lasting antibacterial effects. The higher ethanol content in the hand sanitizer provided in Comparative Example 3 did not result in a significant improvement in disinfection and long-lasting antibacterial effects; instead, its flammability increased storage risks.

[0087] The basic concepts have been described herein. It is obvious that the detailed disclosure above is merely illustrative and does not constitute a limitation of this application. Although not explicitly stated herein, various modifications, improvements, and corrections may be made to this application by those skilled in the art. Such modifications, improvements, and corrections are suggested in this application and therefore remain within the spirit and scope of the exemplary embodiments of this application.

[0088] Meanwhile, this application uses specific terms to describe its embodiments. For example, "an embodiment," "one embodiment," "some embodiments," and / or "some implementations" refer to a particular feature, structure, or characteristic related to at least one embodiment of this application. Therefore, it should be emphasized and noted that "an embodiment," "one embodiment," or "an alternative embodiment" mentioned twice or more in different locations in this application do not necessarily refer to the same embodiment. Furthermore, certain features, structures, or characteristics in one or more embodiments of this application can be appropriately combined.

[0089] Similarly, it should be noted that, in order to simplify the description of this application and thus aid in the understanding of one or more embodiments of the invention, the foregoing description of the embodiments of this application sometimes combines multiple features into one embodiment or its description. However, this disclosure method does not imply that the subject matter of this application requires more features than those mentioned in the claims. In fact, the embodiments have fewer features than all the features of the single embodiments disclosed above.

[0090] Finally, it should be understood that the embodiments described in this application are merely illustrative of the principles of the embodiments of this application. Other modifications may also fall within the scope of this application. Therefore, alternative configurations of the embodiments of this application are considered as examples and not limitations, and are regarded as consistent with the teachings of this application. Accordingly, the embodiments of this application are not limited to the embodiments explicitly described and illustrated in this application.

Claims

1. A hand sanitizer, characterized in that, The hand sanitizer comprises octinididine hydrochloride, ethanol, and a solvent; wherein the mass percentage of octinididine hydrochloride in the hand sanitizer is 0.1%-0.3%, and the mass percentage of ethanol in the hand sanitizer is 50%-60%.

2. The hand sanitizer according to claim 1, characterized in that, The mass percentage of oxytinididine hydrochloride in the hand sanitizer is 0.2%-0.3%.

3. The hand sanitizer according to claim 1, characterized in that, The ethanol content in the hand sanitizer is 58%-60% by mass.

4. The hand sanitizer according to claim 1, characterized in that, The solvent is water, and the solvent accounts for 32.7%-33.75% of the total mass of the hand sanitizer.

5. The hand sanitizer according to claim 1, characterized in that, The hand sanitizer also includes an emulsifier selected from at least one of hexadecyl palmitate and isopropyl myristate.

6. The hand sanitizer according to claim 5, characterized in that, The hand sanitizer also includes a solubilizer, which is behenyl alcohol polyether-10.

7. The hand sanitizer according to claim 1, characterized in that, The hand sanitizer also includes a thickener selected from at least one of EDTA, polyethylene glycol-200, polyethylene glycol-400, and polyethylene glycol-600.

8. The hand sanitizer according to claim 1, characterized in that, The hand sanitizer also includes a skin care agent selected from at least one of glycerin, squalane, jojoba oil, methyl gluceth-20, hydrolyzed corn gluten, bisabolol, and ginger root extract.

9. The hand sanitizer according to claim 1, characterized in that, The hand sanitizer also includes a lubricant, which is dimethyl silicone oil.

10. A method for preparing a hand sanitizer as described in any one of claims 1-9, characterized in that, The preparation method includes: A uniformly mixed solvent and ethanol are used to obtain an intermediate mixture; Add oxytinidin hydrochloride to the intermediate mixture and stir until dissolved to obtain a hand sanitizer.

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