A reagent card incubation device and an immunochromatographic analyzer

By designing a reagent card incubation device that includes a base, an incubation tray, and a drive assembly, the problems of complex structure and low throughput in the prior art are solved, and the rapid transfer and unloading of reagent cards are realized, thereby improving the detection efficiency of the immunochromatographic analyzer.

CN116203232BActive Publication Date: 2026-01-16SHANGHAI I-READER BIOTECH CO LTD
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Patent Information

Application Number
CN202211731869.4
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-12-30
Publication Date
2026-01-16
Estimated Expiration
2042-12-30

AI Technical Summary

Technical Problem

The existing automated multichannel immunochromatographic analyzer has a complex incubation device structure, occupies a large space, and requires time for card unloading, which reduces detection efficiency and instrument throughput.

Method used

A reagent card incubation device was designed, including a base, an incubation tray, a driving component, and a card transfer component. The driving component drives the card transfer component to transfer reagent cards between slots in the incubation tray, and the card is unloaded at the slot. This simplifies the structure and increases throughput.

Benefits of technology

The structure of the reagent card incubation device has been simplified, enabling rapid transfer and unloading of reagent cards, and improving the detection efficiency and throughput of the immunochromatographic analyzer.

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Abstract

The application discloses a reagent card incubation device and an immunochromatographic analyzer, and relates to the technical field of medical detection instruments. The reagent card incubation device comprises a base, an incubation tray arranged on the base, a driving assembly and a card moving assembly connected with the driving assembly. A plurality of slot positions are arranged on the incubation tray along the radial direction of the incubation tray. The driving assembly drives the card moving assembly to transfer the reagent card between the plurality of slot positions and unload the reagent card at one of the slot positions. The reagent card incubation device and the immunochromatographic analyzer can simplify the structure of the incubation device and improve the throughput of the immunochromatographic analyzer.
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Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical detection instruments, in particular to a reagent card incubation device and an immunochromatographic analyzer. BACKGROUND

[0002] Immunochromatographic analysis is a unique immunological analysis method that appeared in the early 1980s. It often uses a strip-shaped fiber chromatographic material as a solid phase. Through capillary action, the sample solution moves on the chromatographic strip, and at the same time, the analyte in the sample reacts with the receptors (such as antibodies or antigens) on the chromatographic material to form an immune complex. The immune complex is enriched or intercepted in a certain area (detection zone) of the chromatographic material during the chromatographic process. Through enzyme reaction or direct use of visual markers (such as colloidal gold), an intuitive experimental phenomenon (such as color development) is obtained. The free marker is separated from the bound marker automatically. This analysis technology is simple, fast, and easy to judge, so it is very suitable for use in diagnosis, health care, physical examination, etc. by hospitals at all levels, families or individuals.

[0003] The prior art automatic multi-channel immunochromatographic analyzer can complete the incubation and testing of multiple samples and multiple items at the same time. Specifically, it includes an incubation device, a droplet device, and a detection device arranged on the incubation device. The incubation device is provided with a plurality of installation slots for reagent cards. The installation slots are used to set the reagent cards. During the rotation of the incubation device, the droplet device drips liquid for the reagent cards, and the detection device is used to detect the reagent cards after the liquid is dripped and incubated for a preset time. After the detection is completed, a special card unloading assembly is needed to push the reagent cards out, so that the structure of the incubation device is complex, occupies a large space, and a card pushing time needs to be reserved to detect the next reagent card, which reduces the detection efficiency of the chromatographic analyzer and the throughput of the immunochromatographic analyzer. SUMMARY

[0004] The purpose of the present application is to provide a reagent card incubation device and an immunochromatographic analyzer, which can simplify the structure of the reagent card incubation device and improve the throughput of the immunochromatographic analyzer.

[0005] The embodiment of the present application provides a reagent card incubation device, which includes a base, an incubation disc arranged on the base, a driving assembly, and a card moving assembly connected with the driving assembly. The incubation disc is provided with a plurality of slot positions along the radial direction of the incubation disc. The driving assembly drives the card moving assembly to transfer the reagent cards between the plurality of slot positions and unload the cards at one of the slot positions.

[0006] As an implementable mode, the card moving assembly comprises a rotating disc coaxially nested with the incubation disc, and a rotating shaft connected with the rotating disc, the rotating shaft being connected with the driving assembly to drive the rotating disc to rotate under the driving of the driving assembly, the rotating disc being provided with a pre-storage card position in the radial direction of the rotating disc, and the rotating disc being fixedly provided with a driving member, the driving member driving the reagent card to move between the pre-storage card position and the slot position when the pre-storage card position is in the same direction as the slot position.

[0007] As an implementable mode, the driving member is further used to push the reagent card in the fixed slot position out of the other end of the fixed slot position to achieve card unloading when the reagent card is moved to the fixed slot position.

[0008] As an implementable mode, the slot position is arranged on the side of the incubation disc close to the base, the card moving assembly is arranged in the interior of the base, and the driving assembly is arranged on the side of the incubation disc away from the base.

[0009] As an implementable mode, the driving member drives the reagent card through a card pushing member arranged on the rotating disc, the card pushing member being provided with push rods extending into the pre-storage card position at both ends in the extension direction of the pre-storage card position, the card pushing member being driven to push the reagent card into the pre-storage card position from one slot position or into another slot position from the pre-storage card position.

[0010] As an implementable mode, the rotating disc is provided with a first photoelectric detector facing the card pushing member, the first photoelectric detector being used to sense the position of the card pushing member relative to the rotating disc, and the pre-storage card position is provided with a second photoelectric detector, the second photoelectric detector being used to sense the state of the pre-storage card position.

[0011] As an implementable mode, the driving assembly comprises an encoder motor, a rotating shaft of the encoder motor being connected with the rotating shaft through a synchronous pulley, a bearing seat being arranged on the side of the incubation disc away from the base, and the rotating shaft being connected with the synchronous pulley through the bearing seat.

[0012] As an implementable mode, the base comprises a shell, the shell being connected with the incubation disc to form a constant-temperature cavity, and the reagent card incubation device further comprises a temperature control assembly, the temperature control assembly comprising a controller, a temperature sensor arranged at the slot position, and a heating assembly arranged in the constant-temperature cavity, the controller controlling the heating assembly according to the temperature information of the temperature sensor to make the slot position be in a preset temperature range.

[0013] As an implementable mode, the heating assembly comprises a heating sheet and a heat-conducting plate between the heating sheet and the card moving assembly, and the heat-conducting plate is made of high-thermal-conductivity material.

[0014] The embodiment of the present application provides an immunochromatographic analyzer, which comprises a machine frame, the reagent card incubation device, a droplet assembly and a detection assembly.

[0015] The beneficial effects of the embodiment of the present application include:

[0016] The reagent card incubation device provided by the present application comprises a base, an incubation disc arranged on the base, a driving assembly and a card moving assembly connected with the driving assembly, a plurality of slots are arranged on the incubation disc along the radial direction of the incubation disc, the driving assembly drives the card moving assembly to transfer the reagent card between the plurality of slots, and the reagent card is unloaded at one of the slots, the driving assembly drives the card moving assembly to transfer the reagent card between the slots, and the reagent card is dripped, incubated, detected and unloaded, the card moving assembly of the embodiment of the present application can unload the reagent card after the reagent card is transferred, so that the structure of the reagent card incubation device can be simplified, the reagent card can be pushed while the reagent card is transferred, and the throughput of the immunochromatographic analyzer is improved. BRIEF DESCRIPTION OF DRAWINGS

[0017] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings needed in the embodiments will be briefly introduced below, and it should be understood that the following drawings only show some embodiments of the present application, and therefore should not be regarded as a limitation on the scope, and for those skilled in the art, other related drawings can also be obtained without creative labor on the basis of these drawings.

[0018] Figure 1 A structural schematic diagram of a reagent card incubation device provided by the embodiment of the present application;

[0019] Figure 2 An exploded schematic diagram of a reagent card incubation device provided by the embodiment of the present application;

[0020] Figure 3 One of structural schematic diagrams of an incubation disc provided by the embodiment of the present application;

[0021] Figure 4 The other of structural schematic diagrams of an incubation disc provided by the embodiment of the present application;

[0022] Figure 5 A structural schematic diagram of a card moving assembly provided by the embodiment of the present application;

[0023] Figure 6 A structural schematic diagram of a driving assembly provided by the embodiment of the present application;

[0024] Figure 7 This is a schematic diagram of a heating assembly provided in an embodiment of this application.

[0025] Icons: 10-Reagent card incubation device; 11-Base; 12-Incubation tray; 121-Slot; 122-Temporary storage position; 123-Drip position; 124-Detection position; 125-Incubation position; 13-Drive assembly; 14-Card transfer assembly; 141-Rotating shaft; 142-Rotating disk; 143-Pre-storage card position; 144-Drive component; 145-Card pusher component; 146-Push rod; 15-Bearing seat; 16-Blocking part; 18-Heating assembly; 181-Heating element; 182-Heat conduction plate; 183-Heat dissipation assembly; 19-Temperature sensor. Detailed Implementation

[0026] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. The components of the embodiments of this application described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0027] Therefore, the following detailed description of the embodiments of this application provided in the accompanying drawings is not intended to limit the scope of the claimed application, but merely to illustrate selected embodiments of the application. All other embodiments obtained by those skilled in the art based on the embodiments of this application without inventive effort are within the scope of protection of this application.

[0028] It should be noted that similar labels and letters in the following figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures.

[0029] In the description of this application, it should be noted that the terms "center," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship commonly used when the product is in use. They are used only for the convenience of describing this application and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application. Furthermore, the terms "first," "second," and "third," etc., are used only to distinguish descriptions and should not be construed as indicating or implying relative importance.

[0030] This application provides a reagent card incubation device 10, such as... Figure 1 and Figure 2As shown, the reagent card incubation device 10 includes a base 11, an incubation tray 12 arranged on the base 11, a driving assembly 13, and a card moving assembly 14 connected with the driving assembly 13. The incubation tray 12 is provided with a plurality of slots 121 along the radial direction of the incubation tray 12. The driving assembly 13 drives the card moving assembly 14 to transfer the reagent card between the plurality of slots 121 and unload the reagent card at one of the slots 121.

[0031] The reagent card incubation device 10 provided by the embodiment of the present application is applied to an immunochromatographic analyzer. The reagent card storage area of the immunochromatographic analyzer pushes the reagent card into the reagent card incubation device 10. The reagent card is dripped in the reagent card incubation device 10. After the reaction solution is dripped on the reagent card, the reaction solution reacts with the antigen-antibody on the reagent card in the constant-temperature incubation environment. Then, the reagent card after the reaction is detected. According to the working principle of the reagent card incubation device 10, the slots 121 in the embodiment of the present application can be divided into a temporary storage slot 122, a dripping slot 123, an incubation slot 125, and a detection slot 124. The temporary storage slot 122 is used to store the reagent card pushed by the reagent card storage area. The dripping slot 123 is used to place the reagent card that needs to be dripped. The incubation slot 125 is used to place the reagent card that is incubated after the dripping is completed. The detection slot 124 is used to detect the reagent card after the incubation is completed. Since the reaction solution reacts with the antigen-antibody on the reagent card (that is, incubation) needs a certain time, the incubation slot 125 can be provided with a plurality of slots.

[0032] When the reagent card incubation device 10 provided by the embodiment of the present application works, the temporary storage slot 122 receives the reagent card from the reagent card storage area. The driving assembly 13 drives the card moving assembly 14 to move to the temporary storage slot 122. The card moving assembly 14 takes the reagent card in the temporary storage slot 122 and moves to the dripping slot 123 under the driving of the driving assembly 13. After the dripping is completed, the above steps are repeated to transfer the reagent card to the incubation slot 125. After the incubation is completed, the above steps are repeated to transfer the reagent card to the detection slot 124. After the detection is completed, the card moving assembly 14 unloads the reagent card in the detection slot 124. The card moving assembly 14 in the embodiment of the present application can not only transfer the reagent card but also unload the reagent card after the detection is completed. In this way, the structure of the reagent card incubation device 10 can be simplified. The reagent card is pushed while being transferred, thereby improving the throughput of the immunochromatographic analyzer. It should be noted that the throughput refers to the number of reagent card detections completed in a certain fixed time, which corresponds to the detection efficiency of the reagent card incubation device 10.

[0033] It should be noted that since the incubation needs a certain time, after the first reagent card is transferred to the incubation slot 125, the next reagent card can be dripped and transferred to the incubation slot 125, and so on until the incubation slot 125 is full of reagent cards for incubation. After the first reagent card is incubated, the first reagent card is detected and unloaded.

[0034] The reagent card incubation device 10 provided by the application comprises a base 11, an incubation disc 12 arranged on the base 11, a driving assembly 13, and a card moving assembly 14 connected with the driving assembly 13. The incubation disc 12 is provided with a plurality of slot positions 121 along the radial direction of the incubation disc 12. The driving assembly 13 drives the card moving assembly 14 to transfer the reagent card between the plurality of slot positions 121 and unload the reagent card at one of the slot positions 121. The driving assembly 13 drives the card moving assembly 14 to transfer the reagent card between the slot positions 121, complete the dripping, incubation, detection and unloading of the reagent card. Since the card moving assembly 14 of the embodiment of the application can achieve the unloading of the reagent card after the transfer of the reagent card, the structure of the reagent card incubation device 10 can be simplified, and the pushing of the reagent card can be achieved while the reagent card is being transferred, thereby improving the throughput of the immune chromatography analyzer.

[0035] Optionally, as shown in Figure 2 and Figure 5 The card moving assembly 14 comprises a rotating disc 142 coaxial with the incubation disc 12 and sleeved with the incubation disc 12, and a rotating shaft 141 connected with the rotating disc 142. The rotating shaft 141 is connected with the driving assembly 13 to drive the rotating disc 142 to rotate under the driving of the driving assembly 13. The rotating disc 142 is provided with pre-storage card positions 143 along the radial direction of the rotating disc 142. The driving assembly 13 is fixedly arranged on the rotating disc 142. When the pre-storage card positions 143 and the slot positions 121 are in the same extension direction, the driving assembly 13 drives the reagent card to transfer between the pre-storage card positions 143 and the slot positions 121.

[0036] The card moving assembly 14 comprises a rotating disc 142 coaxial with the incubation disc 12 and sleeved with the incubation disc 12, so that the rotating disc 142 is arranged in the same plane with the incubation disc 12, thereby making the pre-storage card positions 143 and the slot positions 121 located at the same height. The rotating shaft 141 is connected with the driving assembly 13, so that the driving assembly 13 drives the rotating shaft 141 to rotate and drives the rotating disc 142 to rotate. During the rotation of the rotating disc 142, when the pre-storage card positions 143 and the slot positions 121 are in the same extension direction, the driving assembly 13 drives the reagent card to transfer between the pre-storage card positions 143 and the slot positions 121.

[0037] Specifically, the driving assembly 13 drives the rotating shaft 141 to rotate, and drives the rotating disc 142 to rotate, so that the pre-stored card position 143 is in the same extension direction as the temporary storage position 122, the driving member 144 drives the reagent card to be transferred from the temporary storage position 122 to the pre-stored card position 143, and then the rotating disc 142 rotates under the driving of the driving assembly 13, so that the pre-stored card position 143 is in the same extension direction as the drop position 123, the driving member 144 drives the reagent card to be transferred from the pre-stored card position 143 to the drop position 123, to complete the transfer from the temporary storage position 122 to the drop position 123. Similarly, the transfer from the drop position 123 to the incubation position 125 is completed, and the transfer from the incubation position 125 to the detection position 124 is completed.

[0038] In order to simplify the structure of the reagent card incubation device 10, as shown in Figure 2 、 Figure 3 , the incubation disc 12 is arranged in a ring shape, and the rotating disc 142 is arranged in the ring-shaped enclosed area.

[0039] In an implementable manner of the embodiment, the driving member 144 is further configured to push the reagent card in the fixed slot position 121 out of the other end of the fixed slot position 121 to achieve card unloading when the driving member 144 transfers one reagent card to one fixed slot position 121.

[0040] The fixed slot position 121 refers to a certain slot position 121. In order to improve the detection throughput of the reagent card incubation device 10, the card is directly unloaded from the detection position 124 after the detection is completed, that is, the fixed slot position 121 is the detection position 124. After the detection of the first reagent card is completed, the first reagent card is placed in the detection position 124. When the second reagent card is transferred to the detection position 124 after the second reagent card is incubated, the front end of the second reagent card abuts against the rear end of the first reagent card. During the transfer of the second reagent card, the first reagent card gradually exits the detection position 124 from the other end of the detection position 124, thereby achieving the unloading of the first reagent card. The embodiment adopts the second reagent card to push the first reagent card to achieve the unloading of the first reagent card, which can reduce the card unloading assembly in the prior art, thereby reducing the components of the reagent card incubation device 10, simplifying the structure of the reagent card incubation device 10, and simultaneously, without reserving unloading time, thereby reducing the detection time of the reagent card and improving the throughput of the immunochromatographic analyzer.

[0041] Optionally, as shown in Figure 2 , the slot position 121 is arranged on one side of the incubation disc 12 close to the base 11, the card moving assembly 14 is arranged in the interior of the base 11, and the driving assembly 13 is arranged on the side of the incubation disc 12 away from the base 11.

[0042] In practical application, the base 11 is usually arranged on the frame of the immunochromatographic analyzer, so that the side of the incubation tray 12 provided with the slot positions 121 faces downward, and the card moving assembly 14 is arranged inside the base 11 to realize the function of transferring the reagent cards. Since the space inside the base 11 is limited, the driving assembly 13 is arranged on the other side of the incubation tray 12 to realize effective utilization of the space and reduce the space occupied by the reagent card incubation device 10.

[0043] As known from the above, the side of the incubation tray 12 provided with the slot positions 121 faces downward, so as to avoid the reagent cards from falling under the action of gravity. In addition, the two sides of the side of the slot positions 121 close to the base 11 can be protruded to the center to form limiting portions, and the sliding channel between the two limiting portions is used to move the reagent cards by the card moving assembly 14. The limiting portions limit the vertical direction of the reagent cards.

[0044] In an implementable manner of the embodiment of the present application, as shown in Figure 5 The driving member 144 drives the reagent cards through the pushing member 145 arranged on the rotating disc 142. The pushing member 145 is provided with pushing rods 146 extending into the pre-storage card positions 143 at both ends in the extension direction of the pre-storage card positions 143. The pushing member 145 is driven to drive the pushing rods 146 at both ends to push the reagent cards to enter the pre-storage card positions 143 from one slot position 121 or to enter another slot position 121 from the pre-storage card positions 143.

[0045] Specifically, when the extension directions of the pre-storage card positions 143 and the temporary storage positions 122 are the same, at this time, the pushing rod 146 of the pushing member 145 away from the center of the disc abuts against the outer side wall of the reagent card in the temporary storage position 122. The driving member 144 drives the pushing member 145 to move from the temporary storage position 122 to the pre-storage position, so that the pushing rod 146 drives the reagent card to move into the pre-storage card position 143 when moving inward, so that the reagent card is transferred from the temporary storage position 122 to the pre-storage card position 143. At this time, the pushing member 145 returns to the starting position, and then the rotating disc 142 rotates under the driving of the driving assembly 13, so that the extension direction of the pre-storage card position 143 is the same as that of the drop position 123. At this time, the pushing rod 146 of the pushing member 145 close to the center of the disc abuts against the inner side wall of the reagent card in the temporary storage position 122. The driving member 144 drives the pushing member 145 to move outward again, so that the pushing rod 146 drives the reagent card to move into the drop position 123 when moving outward, so that the reagent card is transferred from the pre-storage card position 143 to the drop position 123 to complete the transfer from the temporary storage position 122 to the drop position 123. Similarly, the transfer from the drop position 123 to the incubation position 125 is completed, and the transfer from the incubation position 125 to the detection position 124 is completed.

[0046] Since the reagent card incubation time is relatively long, after the reagent card is transferred from the drop position 123 to the incubation position 125, the driving member 144 drives the pushing member 145 to move along the circumferential direction of the incubation tray to return to the zero position, and then other reagent cards are transferred.

[0047] Optionally, as shown in Figure 5 The first photoelectric detector is arranged on the rotating disc 142 and faces the pusher 145, and is used to sense the position of the pusher 145 relative to the rotating disc 142. The second photoelectric detector is arranged in the pre-storage card position 143 and is used to sense the state of the pre-storage card position 143.

[0048] The first photoelectric detector is used to sense the position of the pusher 145 relative to the rotating disc 142. As described above, the pusher 145 is used to transfer the reagent card from the pre-storage card position 143 to the slot position 121, or to transfer the reagent card from the slot position 121 to the pre-storage card position 143, so that the pusher 145 has two positions relative to the rotating disc 142, one is a start position close to the rotating disc 142, and the other is an end position far from the rotating disc 142. The first photoelectric detector is used to sense whether the pusher 145 is located at the start position or the end position, so that the state of the pusher 145 can be determined in real time, and the working efficiency of the pusher 145 is improved. In order to detect the two states of the pusher 145, the first photoelectric detector includes two photoelectric detectors, which are used to detect the start position and the end position respectively, and thus the position state of the pusher 145 can be accurately determined.

[0049] The second photoelectric detector is arranged in the pre-storage card position 143 and is used to sense whether the pre-storage card position 143 contains a reagent card, so as to determine the state of the pre-storage card position 143 in real time.

[0050] The moving card assembly 14 includes a plurality of elements, and the plurality of elements need to be electrically connected and / or signal connected with the outside. In order to form a wiring channel, the inside of the rotating shaft can be hollow, and the power lines and / or signal lines of the plurality of elements can pass through the hollow of the rotating shaft to realize electrical connection and / or signal connection. In addition, in order to prolong the service life of the moving card assembly 14, all the signal lines and power lines are made of high-torque-resistant cables to prevent the service life of the cables from being too short due to repeated rotation of the moving card assembly 14.

[0051] In an implementable manner of the embodiment of the present application, as shown in Figure 1 , Figure 6 The driving assembly 13 includes an encoder motor, the rotating shaft of the encoder motor is connected with the rotating shaft 141 through a synchronous pulley, and a bearing seat 15 is arranged on the side of the incubation disc 12 away from the base 11. The rotating shaft 141 passes through the bearing seat 15 and is connected with the synchronous pulley.

[0052] When the driving assembly 13 includes an encoder motor, the position of the rotating disc 142 can be positioned without repeated zero-finding, thereby reducing the time for transferring the reagent card, further improving the detection efficiency of the reagent card, and improving the detection throughput of the reagent card incubation device 10.

[0053] The encoder motor is misaligned with the rotating disc 142 by the synchronous wheel, and a frame is arranged on the incubation disc 12 to fix the encoder motor. In addition, a fixing plate is arranged to fix the rotating disc 142, and the fixing plate is connected with the rotating disc 142 and the incubation disc 12 simultaneously. A bearing seat 15 is arranged on the fixing plate to support the synchronous belt wheel.

[0054] Optionally, as shown in Figure 4 The slot 121 includes a plurality of temporary storage positions 122, a droplet position 123, a detection position 124 and a plurality of incubation positions 125. The droplet position 123 and the incubation position 125 are provided with a blocking part 16 at an end away from the center of the incubation disc 12.

[0055] Since the droplet position 123 and the detection position 124 are used for dropping liquid and detection respectively, the operation time is short, while the incubation position 125 is used for incubation, which needs a long time. Therefore, the slot 121 is arranged as a plurality of temporary storage positions 122, a droplet position 123, a detection position 124 and a plurality of incubation positions 125.

[0056] Since the temporary storage position 122 and the detection position 124 need to be inserted from one end of the slot 121 and removed from the other end of the slot 121, the slot 121 of the temporary storage position 122 and the detection position 124 is a through slot. The droplet position 123 and the incubation position 125 need to be inserted from one end and removed from the same end. Therefore, in order to avoid the reagent card from sliding out of the droplet position 123 and the incubation position 125, the droplet position 123 and the incubation position 125 are provided with a blocking part 16 at an end away from the center of the incubation disc 12.

[0057] The number of the temporary storage position 122 and the incubation position 125 is not limited in the embodiment, and can be set according to the actual incubation condition and the incubation time. Since the temporary storage position 122 and the incubation position 125 are both used for placing the reagent card, the incubation position 125 can be used for incubation when the incubation position 125 is not enough in actual use.

[0058] In addition, in order to further limit the droplet position 123 and the incubation position 125, the width of the slot 121 of the droplet position 123 and the incubation position 125 can be set to be small, as long as the reagent card can be inserted smoothly. In this way, on the one hand, the reagent card can be prevented from sliding out, and on the other hand, the position of the reagent card can be accurately limited. Since the droplet position 123 needs to drop the reagent card into the reaction liquid, accurate positioning of the reagent card can ensure the consistency of the sample dropping position. Similarly, the detection position 124 needs to scan and detect the reagent card, and accurate positioning of the reagent card can ensure the detection accuracy.

[0059] In an implementable manner of the embodiment, as shown inFigure 2 , Figure 7 As shown, the base 11 includes a shell, which is connected to the incubation tray 12 to form a constant temperature chamber. The reagent card incubation device 10 also includes a temperature control component, which includes a controller, a temperature sensor 19 disposed at the slot 121, and a heating component 18 disposed in the constant temperature chamber. The controller controls the heating component 18 according to the temperature information of the temperature sensor 19 so that the slot 121 is within a preset temperature range.

[0060] A constant temperature is beneficial for the incubation of reagent cards. The temperature control components and controller keep the temperature in the constant temperature chamber within a preset range, providing a good temperature environment for the incubation of reagent cards.

[0061] The number of temperature sensors 19 is not limited in this embodiment. One sensor can be set in one incubation position 125, or one sensor can be set in each incubation position 125. Alternatively, temperature sensors 19 can be set in the dropper position 123, the incubation position 125, and the detection position 124. Considering that the number of temperature sensors 19 will increase the cost and control difficulty, this embodiment of the application sets four temperature sensors 19 evenly on the incubation tray 12.

[0062] Optional, such as Figure 7 As shown, the heating assembly 18 includes a heating element 181 and a heat-conducting plate 182 between the heating element 181 and the card transfer assembly 14. The heat-conducting plate 182 is made of a high thermal conductivity material.

[0063] The heat-conducting plate 182 can evenly distribute the heat generated by the heating plate, resulting in a uniform temperature within the constant temperature chamber and preventing large temperature differences that could lead to uncontrollable incubation time. Furthermore, the heat-conducting plate 182, made of a highly thermally conductive material, can rapidly transfer heat, ensuring that the temperature within the constant temperature chamber quickly reaches the preset range after startup.

[0064] In one possible implementation of the embodiments of this application, such as Figure 7 As shown, the heating element 181 is a semiconductor heating element, and the cooling surface of the semiconductor heating element is also connected to a heat dissipation component 183, which passes through the outer casing and communicates with the outside.

[0065] The heat dissipation component 183 can quickly dissipate the cold air from the cooling surface of the semiconductor heating element, thereby improving the heating speed of the heating surface of the semiconductor heating element and reaching the preset temperature in a short time.

[0066] Specifically, the heat dissipation component 183 includes a heat sink that is attached to the cooling surface of the semiconductor heating element 181, and a heat dissipation duct. The heat sink is disposed at one end of the heat dissipation duct, and a cooling fan is disposed at the other end of the heat dissipation duct. The cooling fan can accelerate the air flow within the heat dissipation duct and improve heat dissipation efficiency.

[0067] The application further discloses an immunochromatographic analyzer, comprising a rack, the reagent card incubation device 10 arranged on the rack, and a droplet assembly and a detection assembly arranged on the rack and located above the incubation disc 12 of the reagent card incubation device 10, and used for respectively performing droplet and detection on the reagent card in the incubation disc 12. The immunochromatographic analyzer comprises the same structure and beneficial effects as the reagent card incubation device 10 in the foregoing embodiments. The structure and beneficial effects of the reagent card incubation device 10 have been described in detail in the foregoing embodiments, and will not be described herein again.

[0068] The above merely provides preferred embodiments of the application, but should not be used to limit the application. For those skilled in the art, the application can have various modifications and changes. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the application should be included in the protection scope of the application.

Claims

1. A reagent card incubation device, characterized by, The reagent card incubation device comprises a base, an incubation tray arranged on the base, a driving assembly, and a card moving assembly connected with the driving assembly. The incubation tray is provided with a plurality of slots along the radial direction of the incubation tray. The driving assembly drives the card moving assembly to move the reagent card between the slots and unload the reagent card from one of the slots. The card moving assembly comprises a rotating disc coaxially nested with the incubation tray, and a rotating shaft connected with the rotating disc. The rotating shaft is connected with the driving assembly to drive the rotating disc to rotate under the driving of the driving assembly. The rotating disc is provided with pre-stored card positions along the radial direction of the rotating disc. The rotating disc is fixedly provided with a driving member. When the pre-stored card positions and the slots are in the same direction, the driving member drives the reagent card to move between the pre-stored card positions and the slots.

2. The reagent card incubation device of claim 1, wherein, The driving member is also used to push the reagent card in the fixed slot out of the other end of the fixed slot to achieve unloading when one reagent card is moved to one fixed slot.

3. The reagent card incubation device of claim 1, wherein, The slots are arranged on the side of the incubation tray close to the base. The card moving assembly is arranged inside the base. The driving assembly is arranged on the side of the incubation tray away from the base.

4. The reagent card incubation device of claim 1, wherein, The driving member drives the reagent card through a card pushing member arranged on the rotating disc. The card pushing member is provided with push rods extending into the pre-stored card positions at both ends along the direction of the pre-stored card positions. The card pushing member is driven to push the reagent card into one of the slots or another slot from the pre-stored card position through the push rods at both ends.

5. The reagent card incubation device of claim 4, wherein, The rotating disc is provided with a first photoelectric detector facing the card pushing member to sense the position of the card pushing member relative to the rotating disc. The pre-stored card position is provided with a second photoelectric detector to sense the state of the pre-stored card position.

6. The reagent card incubation device of claim 1, wherein, The driving assembly comprises an encoder motor. The rotating shaft of the encoder motor is connected with the rotating shaft through a synchronous pulley. The side of the incubation tray away from the base is provided with a bearing seat. The rotating shaft passes through the bearing seat and is connected with the synchronous pulley.

7. The reagent card incubation device of claim 1, wherein, The base comprises a shell. The shell is connected with the incubation tray to form a constant temperature cavity. The reagent card incubation device further comprises a temperature control assembly. The temperature control assembly comprises a controller, a temperature sensor arranged at the slot, and a heating assembly arranged in the constant temperature cavity. The controller controls the heating assembly according to the temperature information of the temperature sensor to make the slot be in a preset temperature range.

8. The reagent card incubation device of claim 7, wherein, The heating assembly comprises a heating sheet and a heat conducting plate between the heating sheet and the card moving assembly. The heat conducting plate is made of high thermal conductivity material.

9. An immunochromatographic analyzer characterized by comprising: The reagent card incubation device comprises a base, an incubation tray arranged on the base, a driving assembly, and a card moving assembly connected with the driving assembly. The incubation tray is provided with a plurality of slots along the radial direction of the incubation tray. The driving assembly drives the card moving assembly to move the reagent card between the slots and unload the reagent card from one of the slots. The card moving assembly comprises a rotating disc coaxially nested with the incubation tray, and a rotating shaft connected with the rotating disc. The rotating shaft is connected with the driving assembly to drive the rotating disc to rotate under the driving of the driving assembly. The rotating disc is provided with pre-stored card positions along the radial direction of the rotating disc. The rotating disc is fixedly provided with a driving member. When the pre-stored card positions and the slots are in the same direction, the driving member drives the reagent card to move between the pre-stored card positions and the slots. The driving member is also used to push the reagent card in the fixed slot out of the other end of the fixed slot to achieve unloading when one reagent card is moved to one fixed slot. The slots are arranged on the side of the incubation tray close to the base. The card moving assembly is arranged inside the base. The driving assembly is arranged on the side of the incubation tray away from the base. The driving member drives the reagent card through a card pushing member arranged on the rotating disc. The card pushing member is provided with push rods extending into the pre-stored card positions at both ends along the direction of the pre-stored card positions. The card pushing member is driven to push the reagent card into one of the slots or another slot from the pre-stored card position through the push rods at both ends. The rotating disc is provided with a first photoelectric detector facing the card pushing member to sense the position of the card pushing member relative to the rotating disc. The pre-stored card position is provided with a second photoelectric detector to sense the state of the pre-stored card position. The driving assembly comprises an encoder motor. The rotating shaft of the encoder motor is connected with the rotating shaft through a synchronous pulley. The side of the incubation tray away from the base is provided with a bearing seat. The rotating shaft passes through the bearing seat and is connected with the synchronous pulley. The base comprises a shell. The shell is connected with the incubation tray to form a constant temperature cavity. The reagent card incubation device further comprises a temperature control assembly. The temperature control assembly comprises a controller, a temperature sensor arranged at the slot, and a heating assembly arranged in the constant temperature cavity. The controller controls the heating assembly according to the temperature information of the temperature sensor to make the slot be in a preset temperature range. The heating assembly comprises a heating sheet and a heat conducting plate between the heating sheet and the card moving assembly. The heat conducting plate is made of high thermal conductivity material. The reagent card incubation device comprises a base, an incubation tray arranged on the base, a driving assembly, and a card moving assembly connected with the driving assembly. The incubation tray is provided with a plurality of slots along the radial direction of the incubation tray. The driving assembly drives the card moving assembly to move the reagent card between the slots and unload the reagent card from one of the slots. The card moving assembly comprises a rotating disc coaxially nested with the incubation tray, and a rotating shaft connected with the rotating disc. The rotating shaft is connected with the driving assembly to drive the rotating disc to rotate under the driving of the driving assembly. The rotating disc is provided with pre-stored card positions along the radial direction of the rotating disc. The rotating disc is fixedly provided with a driving member. When the pre-stored card positions and the slots are in the same direction, the driving member drives the reagent card to move between the pre-stored card positions and the slots.

Citation Information

Patent Citations

  • Reagent card incubation device for full-automatic immunochromatographic analyzer

    CN210863759U