A high-speed fully automatic chemiluminescence immunoassay analyzer

Abstract

The present invention relates to a high-speed fully automatic chemiluminescence immunoassay analyzer, belonging to the technical field of biological sample luminescence detection equipment, and comprising a workbench. The upper end of the workbench is provided with a sample inlet and outlet module, a sample transfer module, a sample transmission module, a consumable automatic supply module, a consumable constant temperature turntable, a consumable transfer manipulator, a sample independent mixing module, a sample needle module, a reagent cartridge module, a sample transfer position, an incubation plate module, a reagent needle module, a primary cleaning module, a secondary cleaning module, a sample transfer manipulator, and a reading module. This application has the advantages of convenient maintenance, small occupied space, high detection throughput, and high detection accuracy.

Description

Technical Field

[0001] The present invention relates to a high-speed fully automatic chemiluminescence immunoassay analyzer, belonging to the technical field of biological sample luminescence detection equipment. Background Art

[0002] Chemiluminescence immunoassay is a common medical analysis and detection method. Currently, chemiluminescence immunoassay analyzers are used in hospitals or laboratories to perform luminescence immunoanalysis on the collected biological samples; the chemiluminescence immunoassay analyzer uses a bioluminescent substance or a cofactor participating in the bioluminescence reaction to label an antigen or an antibody. After the immune reaction, a luminescence reaction is used for detection and analysis. Since luminescence immunoassay has the ability to detect ultra-trace amounts and has relatively high sensitivity, it is currently recognized as the most accurate and mature detection method for tumor markers and various hormones. In the detection of the analyzer, throughput is used to represent the detection efficiency of the analyzer, and the larger the throughput, the higher the efficiency.

[0003] The Chinese patent with the publication number CN109541198B discloses a pipeline-type fully automatic chemiluminescence immunoanalysis device. A conveying docking relationship is formed between the sample input unit and the sample transmission unit, a conveying docking relationship is formed between the sample transmission unit and the sample feeding unit, a transfer docking relationship is formed between the sample feeding unit and the reaction unit, a conveying docking relationship is formed between the sample output unit and the sample transmission unit, a conveying docking relationship is formed between the emergency sample adding unit and the sample transmission unit, a transfer docking relationship is formed between the consumable storage unit and the consumable transfer unit, a transfer docking relationship is formed between the reaction unit and the consumable transfer unit, an operation docking relationship is formed between the reaction unit and the reagent refrigerated storage unit, a transfer docking relationship is formed between the reaction unit and the cleaning unit, and a transfer docking relationship is formed between the reading unit and the cleaning unit.

[0004] The inventor believes that when using the above analyzer for luminescence test detection, the above analyzer has the following problems: First, the structure of the above analyzer is complex, occupying a large space, and there is a problem of difficult maintenance; second, when using the above analyzer to detect samples, some samples need to be diluted before detection, and the above analyzer lacks a sample dilution station, which has a certain adverse impact on the overall detection throughput of the machine; third, when the above analyzer cleans the samples in the reaction cups, the cleaning efficiency is low, which also has a certain adverse impact on the throughput of the whole machine; fourth, the overall performance of the above analyzer is unstable, the temperature control performance is poor, and some reagents stored in the whole machine are greatly affected by the environment. After the reagents deteriorate, it has an adverse impact on the detection results. Summary of the Invention

[0005] In view of the deficiencies of the existing technology, the present invention provides a high-speed fully automatic chemiluminescence immunoassay analyzer.

[0006] The technical solution of the present invention to solve the above technical problems is as follows: A high-speed fully automatic chemiluminescence immunoassay analyzer, including a workbench, on which there are a sample loading and unloading module, a sample transfer module, a consumable automatic supply module, a consumable constant temperature turntable, a consumable transfer manipulator, a sample needle module, a reagent warehouse module, an incubation plate module, a reagent needle module, a primary cleaning module, a secondary cleaning module, a sample transfer manipulator, and a reading module;

[0007] A conveying docking relationship is formed between the sample loading and unloading module and the sample transfer module, and the sample transfer module transports the samples stored in the sample loading and unloading module;

[0008] A conveying docking relationship is formed between the consumable automatic supply module and the consumable constant temperature turntable, and the consumable automatic supply module is used to transfer reaction cup consumables into the consumable constant temperature turntable;

[0009] A conveying docking relationship is formed between the consumable transfer manipulator and the consumable constant temperature turntable, the incubation plate module, and the sample independent mixing module, and the consumable transfer manipulator is used to grab the reaction cups in the consumable constant temperature turntable and transfer them to the incubation plate module;

[0010] A conveying docking relationship is formed between the sample needle module and the sample transfer module and the incubation plate module, and the sample needle module is used to transfer the samples in the sample transfer module into the reaction cups in the incubation plate module;

[0011] A conveying docking relationship is formed between the reagent needle module and the reagent warehouse module and the incubation plate module, and the reagent needle module is used to transfer the reagents in the reagent warehouse module into the reaction cups in the incubation plate module;

[0012] A conveying docking relationship is formed between the sample transfer manipulator and the incubation plate module, the primary cleaning module, the reading module, and the secondary cleaning module. The sample transfer manipulator can grab and transfer the reaction cups among the incubation plate module, the primary cleaning module, the reading module, and the secondary cleaning module. The incubation plate module is used to incubate the samples in the reaction cups. The primary cleaning module is used to perform primary cleaning on the samples in the reaction cups. The secondary cleaning module is used to perform secondary cleaning on the samples in the reaction cups. The reading module is used to read the detection values of the samples in the reaction cups.

[0013] On the basis of the above technical solution, the present invention can also be improved as follows:

[0014] Further, a sample transfer module is provided between the sample loading and unloading module and the sample transfer module, and the sample transfer module is used to transfer the samples on the sample loading and unloading module to the sample transfer module.

[0015] Further, a sample transfer position is also provided at the upper end of the workbench. The sample transfer position is located between the incubation tray module and the sample needle module, and is used for diluting the sample.

[0016] Further, a conveying docking relationship is formed between the consumable transfer manipulator and the sample transfer position. The consumable transfer manipulator is used to grab the reaction cup from the consumable constant temperature turntable into the sample transfer position or grab the sample at the sample transfer position into the incubation tray module.

[0017] Further, a sample independent mixing module is provided at the upper end of the workbench. The sample independent mixing module is arranged between the incubation tray module, the sample transfer position and the consumable constant temperature turntable, and is used for mixing the sample and the reagent.

[0018] Further, the sample loading and unloading module includes a routine sample module, an emergency sample module and an online sample module. The sample transfer module includes a sample table and a driving mechanism I. The driving mechanism I is used to drive the sample table to displace between the sample loading and unloading module and the sample transmission module.

[0019] Further, the consumable constant temperature turntable includes a heating sheet I, the incubation tray module includes a heating sheet II, and the primary cleaning module and the secondary cleaning module respectively include a heating block I and a heating block II.

[0020] Further, the consumable constant temperature turntable includes a temperature sensor I, and the incubation tray module includes a temperature sensor II.

[0021] Further, the reagent storage module includes a refrigeration plate and a semiconductor refrigeration sheet, and the refrigeration plate abuts against the semiconductor refrigeration sheet.

[0022] Further, the reading module includes an excitation liquid adding mechanism, and the excitation liquid adding mechanism includes a heating wire.

[0023] Compared with the prior art, the beneficial effects of the present invention are:

[0024] 1. The present application has an original and brand-new layout, with the incubation tray module as the center, and other functional modules are arranged compactly around it. Pipeline operation can be realized between the modules. At the same time, the structure is relatively simple, the maintenance is more convenient, and the space occupied is smaller than that of the traditional analyzer.

[0025] 2. By setting a sample transfer position in this application, when detecting a sample that needs to be diluted, the consumable transfer manipulator first grabs an empty reaction cup and places it in the incubation tray module cup. The incubation tray drives the reaction cup to rotate to the reagent needle module. The reagent needle module sucks the diluent in the reagent storage module and injects the diluent into the reaction cup. The incubation tray module rotates to drive the reaction cup filled with diluent to the consumable transfer manipulator. The consumable transfer manipulator grabs it out to the sample transfer position. The sample needle module sucks the sample to be diluted from the sample storage test tube and injects it into the cup. The consumable transfer manipulator grabs the reaction cup to the sample independent mixing module for mixing and then puts it back to the sample transfer position. At the same time, it grabs an empty cup and places it in another empty position of the sample transfer position. The sample needle module sucks the quantitatively diluted sample and transfers it to another empty cup. The consumable transfer manipulator grabs the new cup and puts it into the incubation tray module, and discards the first reaction cup. The dilution is completed. The whole process takes very little time in the incubation tray module, avoiding resource occupation, thus reducing the impact on the throughput of the whole machine, and thus ensuring the detection throughput of the whole machine;

[0026] 3. By setting a primary cleaning module and a secondary cleaning module in this application, when some test samples need to be incubated after primary cleaning and then secondary cleaning, the primary cleaning module can be used to first clean the sample in the reaction cup. Then the sample transfer manipulator grabs the reaction cup that has completed primary cleaning into the incubation tray module, and then incubates the reaction cup. Then the sample transfer manipulator can grab the reaction cup onto the secondary cleaning mechanism module to clean the sample in the reaction cup again. When the secondary cleaning module cleans the sample in the reaction cup, the primary cleaning module can clean the sample in other reaction cups, thus reducing the problem of occupying the whole machine for cleaning, reducing the impact on the throughput of the whole machine, and thus ensuring the detection throughput of the whole machine;

[0027] 4. By setting heating sheet 1, heating sheet 2, heating block 1 and heating block 2 in this application, it is ensured that the temperature remains constant at about 37 °C from the time the sample enters the analyzer until the test is completed, thus reducing the impact of the ambient temperature on the sample, and thus ensuring the detection accuracy of the sample. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 It is a schematic structural diagram of a high-speed fully automatic chemiluminescence immunoassay analyzer in an embodiment of this application;

[0029] Figure 2 It is a schematic structural diagram of highlighting the workbench in an embodiment of this application;

[0030] Figure 3 It is a schematic structural diagram of highlighting the sample inlet and outlet module in an embodiment of this application;

[0031] Figure 4 It is a schematic structural diagram of highlighting the lifting plate in an embodiment of this application;

[0032] Figure 5 Schematic structural diagram highlighting the sample transfer module in the embodiments of the present application;

[0033] Figure 6 Schematic structural diagram highlighting the rail change mechanism in the embodiments of the present application;

[0034] Figure 7 Schematic structural diagram highlighting the consumable automatic supply module in the embodiments of the present application;

[0035] Figure 8 Schematic structural diagram highlighting the consumable constant temperature turntable in the embodiments of the present application;

[0036] Figure 9 Schematic structural diagram highlighting the sample independent mixing module in the embodiments of the present application;

[0037] Figure 10 Schematic structural diagram highlighting the incubation tray module in the embodiments of the present application;

[0038] Figure 11 Schematic structural diagram highlighting the reagent storage module in the embodiments of the present application;

[0039] Figure 12 Schematic structural diagram highlighting the primary cleaning module in the embodiments of the present application;

[0040] Figure 13 Schematic structural diagram highlighting the mounting block in the embodiments of the present application;

[0041] Figure 14 Schematic structural diagram highlighting the reading module in the embodiments of the present application;

[0042] Figure 15 Schematic structural diagram highlighting the excitation liquid adding mechanism in the embodiments of the present application;

[0043] Figure 16 Schematic structural diagram highlighting the heating wire in the embodiments of the present application;

[0044] Figure 17 Schematic structural diagram highlighting the slide plate in the embodiments of the present application.

[0045] In the figure, 100, workbench; 1, sample in and out module; 11, conventional sample module; 12, emergency sample module; 13, online sample module; 14, conventional sample storage basket; 15, emergency sample storage basket; 16, test tube rack; 17, online sample plate; 18, lower plate; 19, online sample gap; 2, sample transfer module; 21, sample table; 22, driving mechanism 1; 23, motor 1; 24, synchronous belt 1; 25, lifting motor; 251, synchronous belt 4; 26, lifting plate; 27, motor 2; 271, synchronous belt; 28, toggle shaft; 281, toggle slot; 29, support block; 3, sample transfer module; 31, conventional sample transport track; 32, emergency sample transport track; 33, return Return track; 34. Synchronous belt three; 4. Track change mechanism; 41. Track change frame; 42. Track change plate; 43. Track change block; 44. Slider; 45. Push rod; 46. Track change motor; 47. Baffle; 48. Track change gap; 5. Automatic consumables supply module; 51. Constant temperature turntable for consumables; 52. Rotating motor one; 53. Heating plate one; 54. Consumables transfer manipulator; 61. Sample needle module; 62. Pipette needle; 63. Reagent compartment module; 64. Reagent test kit storage tank; 65. Reagent test kit; 66. Incubation tray module; 67. Heating plate two; 68. Temperature sensor two; 69. Incubation tank; 71. Sample transfer position; 72. Bracket; 73. Motor three; 74. Transfer tray; 75. Transfer hole; 76. Reagent needle module ;77. Sample transfer manipulator;8. Sample independent mixing module;81. Motor four;82. Mixing rack;83. Rotating seat;84. Mixing hole one;85. Rotating block;86. Mixing hole two;87. Limiting plate;88. Limiting shaft;89. Limiting hole;9. One-time cleaning module;91. Lower rack;92. Hollow shaft;93. Turntable;94. Motor five;95. Upper plate;96. Screw motor two;97. Sliding rack;98. Extraction needle;99. Dispensing needle;101. Mounting shaft;102. Mixing plate;103. Screw motor three;104. Motor six;105. Mixing element;106. Pre-excitation liquid addition needle;107. Magnetic plate;108. Mixing tank;109. Magnet one;201. Mounting block ; 202, magnet two; 203, mixing cap; 204, retaining spring; 205, abutment ring; 206, buffer spring; 207, vertical axis; 208, heating block one; 301, secondary cleaning module; 401, reading module; 402, reading stand; 403, reading box; 404, cup placement hole; 405, reading seat; 406, cup slot; 407, motor seven; 501, excitation liquid adding mechanism; 502, heating wire; 503, excitation liquid adding needle; 504, mounting tube; 505, heat conducting tube; 506, detection camera; 507, screw motor four; 508, waste liquid needle holder; 509, waste liquid needle; 601, waste liquid cup axis one; 602, waste liquid cup axis two; 603, waste collection tube; 604, slide plate. DETAILED DESCRIPTION

[0046] To make the above objects, features, and advantages of the present invention more obvious and understandable, the following provides a detailed description of the specific embodiments of the present invention. Many specific details are set forth in the following description to facilitate a full understanding of the present invention. However, the present invention can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without departing from the connotation of the present invention. Therefore, the present invention is not limited by the specific embodiments disclosed below.

[0047] On the premise of understanding the technical solution of this embodiment, it is necessary to further explain the specific meanings of the following terms. Among them, forming a conveying and docking relationship means that there is a direct material transfer interaction between two modules; the synchronous belts involved in this application all refer to those including a driving pulley, a driven pulley, a belt body, and a guiding pulley when necessary. Since the synchronous belt is a very mature prior art, it will not be elaborated in this application.

[0048] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those of ordinary skill in the technical field to which this invention belongs. The terms used in the description of the present invention herein are only for the purpose of describing specific embodiments and are not intended to limit the present invention.

[0049] Such as Figure 1 and Figure 2As shown in the figure, a high-speed fully automatic chemiluminescence immunoassay analyzer includes a workbench 100. At the upper end of the workbench 100, there are a sample loading and unloading module 1, a sample transfer module 2, a sample transmission module 3, a consumable automatic supply module 5, a consumable constant temperature turntable 51, a consumable transfer manipulator 54, a sample independent mixing module 8, a sample needle module 61, a reagent storage module 63, a sample transfer position 71, an incubation plate module 66, a reagent needle module 76, a primary cleaning module 9, a secondary cleaning module 301, a sample transfer manipulator 77, and a reading module 401. The sample loading and unloading module 1 stores the samples. The samples can be stored in the sample loading and unloading module 1 before and after sample sampling. The sample transfer module 2 can transfer the samples in the sample loading and unloading module 1 to the sample transmission module 3. The sample transmission module 3 can transmit the samples. The consumable reaction cups are arranged and supplied by the consumable automatic supply module 5 into the consumable constant temperature turntable 51. The consumable constant temperature turntable 51 can heat the reaction cups and heat the reaction cups to 37°C. The consumable transfer manipulator 54 can grasp the reaction cups and grasp the reaction cups into the incubation plate module 66 or the sample transfer position 71. The sample needle module 61 is located beside the sample transmission module 3. The sample needle module 61 can aspirate the samples transported by the sample transmission module 3 and inject the samples into the reaction cups in the incubation plate module 66 or the sample transfer position 71. The reagent storage module 63 stores the reagents. The reagent needle module 76 can aspirate and transfer the reagents in the reagent storage module 63 into the reaction cups in the incubation plate module 66. Then, the consumable transfer manipulator 54 grabs the reaction cups with reagents and samples added into the sample independent mixing module 8. The sample independent mixing module 8 can drive the reaction cups to rotate, so as to facilitate the mixing process of the samples and reagents in the reaction cups. After mixing the reagents and samples in the reaction cups, the consumable transfer manipulator 54 can grab the reaction cups back into the incubation plate module 66. The incubation plate module 66 performs constant temperature and timed incubation on the samples and reagents in the reaction cups. When the incubation is over, the sample transfer manipulator 77 grabs the reaction cups out to the primary cleaning module 9 for cleaning. After the cleaning is over, the sample transfer manipulator 77 grabs the reaction cups out to the reading module 401. After adding the excitation solution into the reaction cups by the reading module 401, the reading module 401 can read the samples and measure the concentration values. After reading the values, the sample transfer manipulator 77 grabs the reaction cups again, and finally discards the reaction cups;For samples that require a two-step detection method, after the sample in the reaction cup is washed by the primary washing module 9, the sample transfer manipulator 77 grabs the reaction cup again and places it in the incubation tray module 66. The reagent needle module 76 adds reagents to the reaction cup again, and then the reaction cup is incubated at a constant temperature in the incubation tray module 66 again. After the secondary incubation is completed, the sample transfer manipulator 77 grabs the reaction cup after secondary incubation in the incubation tray module 66 and places it in the secondary washing module 301. After the secondary washing module 301 washes the sample in the reaction cup, the sample transfer manipulator 77 grabs the reaction cup and places it in the reading module 401 to read the value. After reading the sample in the reaction cup, the sample transfer manipulator 77 grabs the reaction cup and then discards the reaction cup.

[0050] As Figure 1 , Figure 2 and Figure 3 shown, the sample loading and unloading module 1 includes a regular sample module 11, an emergency sample module 12, and an online sample module 13. The regular sample module 11 includes a number of regular sample storage baskets 14 arranged at the upper end of the workbench 100. The emergency sample module 12 includes an emergency sample storage basket 15 arranged at the upper end of the workbench 100. A number of test tube racks 16 are slidably connected in both the regular sample storage basket 14 and the emergency sample storage basket 15. Test tubes containing samples are inserted into the test tube racks 16. When the sample needs to be detected, first place the sample to be detected in a test tube, then insert the test tube into the test tube rack 16, and then insert the test tube rack 16 into the regular sample storage basket 14 or the emergency sample storage basket 15 according to the type of the sample. The online sample module 13 is arranged at the upper end of the workbench 100. The online sample module 13 includes four online sample plates 17 and a lower plate 18. The online sample plates 17 are arranged at the upper end of the lower plate 18. An online sample gap 19 adapted to the test tube rack 16 is left between adjacent online sample plates 17. When the analyzer needs to be used in conjunction with other sample conveying machines, the other sample conveying machines can transport the test tube rack 16 and make the test tube rack 16 flow into the analyzer through the online sample gap 19. Thus, by setting the regular sample module 11, the emergency sample module 12, and the online sample module 13, the sample loading operation for three different types of samples can be realized. At the same time, three regular sample storage baskets 14 are provided, which can meet the large-scale storage of regular samples. Therefore, after one feeding, the detection needs for a long time can be met.

[0051] As Figure 1 , Figure 2 , Figure 3 and Figure 4As shown, the sample transfer module 2 includes a sample table 21 and a driving mechanism 22. The driving mechanism 22 includes a motor 23 and a synchronous belt 24. The sample table 21 is connected to the synchronous belt 24. After starting the motor 23, the motor 23 can drive the sample table 21 to move between the sample in-and-out module and the sample transmission module 3. A lifting motor 25 is provided on the sample table 21. The output shaft of the lifting motor 25 is provided with a synchronous belt 251. The lifting motor 25 is connected to a lifting plate 26 through the synchronous belt 251. The sample table 21 is provided with a lifting motor 25. Motor 27, the output shaft of motor 27 is provided with a synchronous belt 271, the synchronous belt 271 is provided with a vertical toggle shaft 28, the toggle shaft 28 is connected to the lifting plate 26, the sample table 21 is provided with a strip hole adapted to the toggle shaft 28, the lower end of the test tube rack 16 is provided with a toggle hole adapted to the toggle shaft 28, the conventional sample storage basket 14, the emergency sample storage basket 15 and the lower plate 18 are provided with a toggle groove 281 adapted to the toggle shaft 28, the upper end of the sample table 21 is provided with a support block 2 that conflicts with the lower end of the test tube rack 16 9. When the sample in the sample inlet and outlet module 1 needs to be transported to the sample transport module 3, the motor 27 and the synchronous belt 271 drive the toggle shaft 28 to move toward the test tube rack 16 where the sample to be tested is stored. When the toggle shaft 28 is aligned with the toggle hole, the lifting motor 25 drives the lifting plate 26 to rise, so that the toggle shaft 28 can be inserted into the toggle hole. The motor 27 is started again. The motor 27 drives the toggle shaft 28 to move through the synchronous belt 271, so that the test tube rack 16 can be moved to the support block 29. Then the motor 1 is started. 3. Motor 1 23 and synchronous belt 1 24 cooperate to drive the test tube rack 16 to the sample transmission module 3. Then, starting the lifting motor 25 and motor 2 27 again can move the test tube rack 16 from the support block 29 to the sample transmission module 3. When the analyzer is used online, the test tube rack 16 is transported to the online sample gap 19 by an external transport device. Similarly, the toggle shaft 28 can be driven by motor 2 27 and the lifting motor 25 to move the test tube rack 16 in the online sample gap 19 to the sample transmission module 3.

[0052] like Figure 1 、 Figure 2 and Figure 5 As shown, the sample transmission module 3 includes a conventional sample transport track 31, an emergency sample transport track 32 and a return track 33. The sample transmission module 3 is respectively provided with three synchronous belts 34. The three synchronous belts 34 are respectively arranged in the conventional transport track, the emergency transport track and the return track 33. The transport directions of the synchronous belts 34 arranged at the conventional transport track and the emergency transport track are the same. The return track 33 is opposite to the direction of the test tube rack 16 transported in the conventional transport track and the emergency transport track. The synchronous belt 34 can transport the test tube rack 16 to a position close to the sample needle module 61, thereby facilitating the sample needle module 61 to transfer the sample in the test tube.

[0053] likeFigure 1 , Figure 2 , Figure 5 and Figure 6 As shown in Figure 1 , Figure 2 , Figure 5 and Figure 6 , at one end of the sample transfer module 3 away from the sample transfer module 2, there is a track-changing mechanism 4. The track-changing mechanism 4 includes a track-changing frame 41, a track-changing plate 42, a track-changing block 43 and a slider 44. The track-changing plate 42 is provided with a track-changing motor 46. The track-changing motor 46 is connected to the track-changing block 43 through a synchronous belt 271. Four baffles 47 are provided at the upper end of the track-changing frame 41. The lower ends of the baffles 47 are slidably connected to the track-changing frame 41. One end of the slider 44 close to the baffle 47 is provided with a horizontal push rod 45. Both the slider 44 and the track-changing block 43 are slidably connected to the track-changing plate 42. A track-changing gap 48 is left between adjacent baffles 47. Two of the baffles 47 are connected to the track-changing block 43, and the other two baffles 47 are connected to the slider 44. When it is necessary to return the test tube rack 16 transported in the conventional sample transport track 31 and the emergency sample transport track 32, after starting the track-changing motor 46, the track-changing motor 46 can drive the track-changing block 43 through the synchronous belt 271. After the track-changing block 43 contacts the push rod 45, it can push the slider 44 and drive the baffle 47 at the same time, so that the test tube rack 16 that has completed sampling in the conventional sample transport track 31 or the emergency sample transport track 32 can be displaced to the return track 33, thus facilitating the return of the test tube rack 16.

[0054] As Figure 1 , Figure 2 , Figure 7 and Figure 8 As shown in Figure 1 , Figure 2 , Figure 7 and Figure 8 , before using the analyzer to perform luminescence detection on the sample, first put the consumable reaction cup into the consumable automatic supply module 5. The consumable automatic supply module 5 can sequentially transport the reaction cups into the consumable constant temperature turntable 51. The consumable constant temperature turntable 51 includes a rotation motor 52, a heating sheet 53 and a temperature sensor 54. When the reaction cup falls into the consumable constant temperature turntable 51, the heating sheet 53 is powered on. The heating sheet 53 can heat the inside of the consumable constant temperature turntable 51. When the temperature is too high, after the temperature sensor 54 monitors that the temperature is too high, it can cut off the power supply to the heating sheet 53. Through the regulation of the temperature sensor 54, the consumable constant temperature turntable 51 can always be maintained at about 37 °C, thus facilitating the preheating of the reaction cup.

[0055] As Figure 1 , Figure 2 , Figure 7As shown, the consumable transfer manipulator 54 is a three-dimensional grasping manipulator. The consumable transfer manipulator 54 includes a three-dimensional motion structure and a grasping structure. The three-dimensional motion structure can drive the grasping structure to move in the X-axis, Y-axis, and Z-axis directions. The grasping structure can grasp the reaction cups. Thus, the consumable transfer manipulator 54 can grasp the reaction cups and displace them, and can grasp the reaction cups between the consumable constant temperature turntable 51, the incubation tray module 66, the sample independent mixing module 8, and the sample transfer position 71. The sample needle module 61 includes a liquid suction needle 62. A pump is externally connected to the liquid suction needle 62. At the same time, the sample needle module 61 further includes a lead screw motor two 96 for driving the liquid suction needle 62 to lift and a rotary motor for driving the liquid suction needle 62 to rotate. The sample needle module 61 can suck the samples in the sample transfer module 3 and transfer them into the reaction cups in the incubation tray module 66 or the sample transfer position 71.

[0056] As Figure 1 , Figure 2 and Figure 11 shown, the reagent warehouse module 63 is provided with a plurality of reagent kit storage slots 64. The reagent warehouse module 63 further includes a reagent kit 65 arranged in the reagent kit storage slot 64. The reagent warehouse module 63 includes a refrigeration plate and a semiconductor refrigeration sheet. The refrigeration plate abuts against the semiconductor refrigeration sheet. After the semiconductor refrigeration sheet is powered on, the semiconductor refrigeration sheet starts to refrigerate, and can transfer the cold source to the refrigeration plate. The refrigeration plate is made of a metal material. Thus, the refrigeration plate can transfer the cold source into the reagent warehouse module 63, so as to facilitate refrigerating the reagents stored in the reagent kit 65.

[0057] As Figure 1 , Figure 2 and Figure 10 shown, the incubation tray module 66 includes a heating sheet two 67 and a temperature sensor two 68. The incubation tray module 66 is provided with a plurality of incubation slots 69. After adding the samples and reagents into the reaction cups and placing the reaction cups in the incubation slots 69, the heating sheet two 67 is powered on. By setting the temperature sensor two 68, the reaction cups placed in the incubation slots 69 can be kept at a constant temperature of 37 °C, so as to facilitate the full reaction of the reagents and the samples.

[0058] As Figure 1 , Figure 2 and Figure 7 shown, the sample transfer position 71 includes a bracket 72 and a motor three 73. The motor three 73 is arranged on the bracket 72. A transfer disk 74 is provided on the output shaft of the motor three 73. The transfer disk 74 is provided with two transfer holes 75. The transfer holes 75 are adapted to the reaction cups. After inserting the reaction cups into the transfer holes 75, the motor three 73 drives the transfer plate to rotate. At the same time, the provision of the transfer holes 75 can also play a role in placing the reaction cups.

[0059] As Figure 1 , Figure 2 and Figure 7As shown, the reagent needle module 76 has the same structure as the sample needle module 61, both of which are used to absorb and transfer liquids. Therefore, the specific structure of the reagent needle module 76 will not be described in detail here. Similarly, the specific structure of the sample transfer manipulator 77 is the same as that of the consumable transfer manipulator 54 and will not be described here either.

[0060] As Figure 1 , Figure 2 , Figure 7 and Figure 9 shown, the sample independent mixing module 8 includes a motor four 81 and a mixing rack 82. One end of the output shaft of the motor four 81 passes through the mixing rack 82 and is provided with a rotating seat 83. One end of the rotating seat 83 away from the motor four 81 is eccentrically provided with a mixing hole one 84. A rotating block 85 is arranged in the mixing hole one 84 of the rotating seat 83, and a bearing is arranged between the rotating block 85 and the rotating seat 83. The rotating block 85 is provided with a mixing hole two 86 adapted to the reaction cup. A vertical limiting plate 87 is arranged at the upper end of the mixing rack 82, and a horizontal limiting shaft 88 is arranged on the limiting plate 87. The rotating block 85 is provided with a limiting hole 89 adapted to the limiting shaft 88. The height of the limiting hole 89 is greater than the diameter of the limiting shaft 88. When it is necessary to mix the sample and reagent in the reaction cup, the reaction cup is inserted into the mixing hole two 86 and the motor four 81 is started. Since the rotating block 85 is eccentrically arranged in the rotating seat 83 and is provided with the limiting shaft 88, the rotating block 85 can shake, so as to facilitate the uniform mixing of the materials in the reaction cup placed in the mixing hole two 86.

[0061] As Figure 1 , Figure 2 , Figure 12 and Figure 13As shown, the primary cleaning module 9 and the secondary cleaning module 301 have the same structure. The primary cleaning module 9 and the secondary cleaning module 301 are respectively arranged on both sides of the reading module 401, and the primary cleaning module 9 and the secondary cleaning module 301 are centrally symmetrically arranged with the reading module 401 as the center point. The primary cleaning module 9 includes a lower frame 91 and a hollow shaft 92. The hollow shaft 92 is arranged at the upper end of the lower frame 91. A turntable 93 is rotatably connected to the middle of the hollow shaft 92. The turntable 93 is provided with a number of through holes adapted to the reaction cups. A fifth motor 94 for driving the turntable 93 to rotate is provided on the lower frame 91. An upper plate 95 is provided at the upper end of the hollow shaft 92. A second lead screw motor 96 is provided at the upper end of the upper plate 95. A sliding frame 97 is provided on the sliding seat of the second lead screw motor 96. Four liquid extraction needles 98 and a liquid distribution needle 99 are provided on the sliding frame 97. When the turntable 93 drives the reaction cup to rotate one week, the sample in the reaction cup can be cleaned four times. Both the liquid extraction needles 98 and the liquid distribution needle 99 are externally connected with liquid pipes and pumps. The liquid extraction needles 98 can extract the liquid in the reaction cup, and the liquid distribution needle 99 can inject the cleaning liquid into the reaction cup. The liquid extraction needles 98 and the liquid distribution needle 99 cooperate to realize the cleaning operation of the sample in the reaction cup. When it is necessary to clean the sample in the reaction cup placed on the turntable 93, the second lead screw motor 96 drives the sliding frame 97 to descend, so as to facilitate the cleaning of the sample in the reaction cup.

[0062] As Figure 1 , Figure 2 , Figure 12 and Figure 13 As shown, a number of vertical mounting shafts 101 are provided at the upper end of the lower frame 91. A mixing plate 102 is slidably connected to the mounting shafts 101. A third lead screw motor 103 is provided at the upper end of the lower frame 91. The sliding seat of the third lead screw motor 103 is connected to the mixing plate 102. A sixth motor 104 is provided at the lower end of the mixing plate 102. A mixing member 105 is rotatably connected to the mixing plate 102. The upper end of the mixing member 105 passes through the mixing plate 102 and is aligned with the liquid distribution needle 99. The working principle of the mixing member 105 is the same as the mixing structure and principle of the sample independent mixing module 8, and both adopt the methods of bearing cooperation, eccentric connection and shaft limit. When the liquid distribution needle 99 adds the cleaning liquid into the reaction cup, the third lead screw motor 103 drives the mixing plate 102 to rise, so that the reaction cup is inserted into the mixing member 105, and then the sixth motor 104 is started to drive the mixing member 105 to vibrate, so as to mix the reaction cup added with the cleaning liquid, thereby improving the cleaning effect of the sample in the reaction cup. A pre-excitation liquid adding needle 106 also passes through the upper plate 95. Through the pre-excitation liquid adding needle 106, it is convenient to add the pre-excitation liquid into the reaction cup after the cleaning is completed.

[0063] As Figure 1 , Figure 2 , Figure 12 and Figure 13As shown in the figure, a magnetic plate 107 is provided at the upper end of the mounting shaft 101. The magnetic plate 107 is provided with a mixing groove 108 adapted to the mixing member 105. A first magnet 109 is provided on the outer side surface of the magnetic plate 107. An installation block 201 is provided at the lower end of the magnetic plate 107. The installation block 201 is provided with a number of second magnets 202 facing the first magnet 109. The lower end of the liquid extraction needle 98 can extend into the gap between the first magnet 109 and the second magnet 202. By providing the first magnet 109 and the second magnet 202, the problem that the liquid extraction needle 98 sucks away the magnetic beads in the reaction cup can be reduced. A mixing cap 203 is slidably connected to the upper plate 95. A snap spring 204 that abuts against the upper plate 95 is provided at the upper end of the mixing cap 203. A middle hole adapted to the liquid separation needle 99 is provided in the middle of the mixing cap 203. When the mixing member 105 jacks up the reaction cup for mixing operation, the upper end of the reaction cup can be stuck in the mixing cap 203. A butting ring 205 is provided at the lower end of the mixing cap 203. The outer diameter of the butting ring 205 is larger than the outer diameter of the mixing cap 203. A buffer spring 206 is provided between the butting ring 205 and the upper plate 95. When the reaction cup is jacked up, providing the buffer spring 206 can reduce the problem of damage to the mixing cap 203.

[0064] As Figure 1 , Figure 2 , Figure 12 and Figure 13 shown, the primary cleaning module 9 further includes a vertical shaft 207 and a first heating block 208. The first heating block 208 is provided at the upper end of the vertical shaft 207. A heating gap is left between the first heating block 208 and the magnetic plate 107. When the turntable 93 drives the reaction cup after cleaning to move in the heating gap, after the first heating block 208 is powered on, the first heating block 208 can heat the reaction cup in the heating gap, so as to ensure that the temperature of the sample always remains at 37 °C, thereby ensuring the accuracy of sample detection. The secondary cleaning module 301 is provided with a second heating block, and its function is the same as that of the first heating block 208. The other structures of the secondary cleaning module 301 are also the same as those of the primary cleaning module 9, so the secondary cleaning module 301 will not be described in detail here.

[0065] As Figure 1 , Figure 2 , Figure 14 , Figure 15 and Figure 16As shown in the figure, the reading module 401 includes a reading rack 402 and a hollow reading box 403. An opening cup hole 404 is provided at the upper end of the reading box 403. A reading seat 405 that can slide within the reading box 403 is provided inside the reading box 403. A cup groove 406 adapted to the reaction cup is provided on the reading seat 405. A seventh motor 407 for driving the reading seat 405 to slide within the reading box 403 is provided at the lower end of the reading rack 402. The seventh motor 407 drives the reading seat 405 to slide through a synchronous belt 271. An excitation liquid adding mechanism 501 is provided at the upper end of the reading box 403. The excitation liquid adding mechanism 501 includes a heating wire 502, an excitation liquid adding needle 503, and a mounting cylinder 504. The mounting cylinder 504 is provided at the upper end of the reading box 403. A heat conducting cylinder 505 is provided inside the mounting cylinder 504. A card slot adapted to the heating wire 502 is provided on the heat conducting cylinder 505. The excitation liquid adding needle 503 is inserted through the mounting cylinder 504. An adding hole facing the excitation liquid needle is provided on the reading box 403. The excitation liquid adding needle 503 is externally connected to a liquid pipe and a pump. A detection camera 506 is provided on the side of the reading box 403. Detection holes communicating with each other are provided on the reading box 403 and the reading seat 405. When it is necessary to detect the sample in the reaction cup, the sample transfer manipulator 77 grabs the reaction cup that has been cleaned on the primary cleaning module 9 or the secondary cleaning module 301 and places it at the emptying hole. The reaction cup falls into the cup groove 406. The seventh motor 407 drives the reading seat 405 to displace within the reading box 403. When the reaction cup is aligned with the excitation liquid adding needle 503, the excitation liquid adding needle 503 adds the excitation liquid to the reaction cup. At the same time, the detection camera 506 detects the luminescence result of the sample after adding the excitation liquid; the cooperation of the heating wire 502 and the heat conducting cylinder 505 can heat the excitation liquid, so that the excitation liquid added to the reaction cup can always be maintained at 37 °C, thereby further ensuring the detection accuracy of the sample.

[0066] As Figure 1 , Figure 2 , Figure 14 , Figure 15 and Figure 16 shown, a waste liquid hole is also provided on the reading box 403. A fourth lead screw motor 507 is provided on the reading rack 402. A sliding seat of the fourth lead screw motor 507 is connected to a waste liquid needle holder 508. A waste liquid needle 509 facing the waste liquid hole is provided on the waste liquid needle holder 508. The waste liquid needle 509 is externally connected to a waste liquid pipe and a pump. After the sample in the reaction cup is detected, the fourth lead screw motor 507 can drive the waste liquid needle 509 to descend. The waste liquid needle 509 is inserted into the reaction cup from the waste liquid hole, so as to facilitate sucking out the waste liquid in the reaction cup.

[0067] As Figure 1 , Figure 2 , Figure 14 and Figure 17As shown, there is a waste liquid cup shaft 601 between the reading box 403 and the primary cleaning module 9. A waste liquid cup channel 1 is provided inside the waste liquid cup shaft 601. After the reaction cup finishes reading in the reading module 401, the sample transfer manipulator 77 can grab the reaction cup to the upper end of the waste liquid cup shaft 601, and the reaction cup can be discharged from the waste liquid cup channel 1.

[0068] As Figure 1 , Figure 2 , Figure 14 and Figure 17 As shown, there is also a waste liquid cup shaft 602 on the workbench 100. The waste liquid cup shaft 602 is located between the sample transfer position 71 and the consumable constant temperature turntable 51. A waste liquid cup channel 2 is provided inside the waste liquid cup shaft 602. When diluting the sample at the sample transfer position 71, the reaction cup used during dilution can be discharged from the waste liquid cup channel 2. The workbench 100 is provided with a waste collection cylinder 603 below the waste liquid cup channel 2. There is an inclined slide plate 604 between the lower end of the waste liquid cup shaft 601 and the waste collection cylinder 603. Through the slide plate 604 and the waste liquid cup shaft 602, all the reaction cups used in this analyzer can be discharged into the waste collection cylinder 603.

[0069] The implementation principle of an embodiment of a high-speed fully automatic chemiluminescence immunoassay analyzer in this application is as follows: The sample flows from the sample inlet and outlet module 1 through the sample transfer module 2 into the sample transfer module 3. The sample transfer module 3 transfers the sample and transfers the test tube rack 16 containing the sample to the sample needle module 61. At the same time, the consumable reaction cups are arranged by the consumable automatic supply module 5 into the consumable constant temperature turntable 51. After being heated and kept at a constant temperature of 37 °C by the consumable constant temperature turntable 51, they are grabbed by the consumable transfer manipulator 54 and placed into the incubation tray module 66 or the sample transfer position 71. For dilution items, sample dilution is carried out at the sample transfer position 71 to ensure the fluidity of conventional samples. The sample needle module 61 aspirates the sample and distributes it into the reaction cups in the incubation tray module 66. The reagent needle module 76 aspirates the reaction reagent from the reagent storage module 63 and adds it into the corresponding test item reaction cups in the incubation tray module 66. Then, the consumable transfer manipulator 54 grabs the reaction cups to the sample independent mixing module 8 for mixing treatment. After mixing is completed, they are grabbed back to the incubation tray module 66 for 37 °C constant temperature timed incubation. After the incubation time arrives, the sample transfer manipulator 77 grabs the reaction cups out to the primary cleaning module 9 for cleaning. After cleaning is completed, they are grabbed to the reading module 401 for reading and measuring the concentration value, and then the reaction cups are discarded. For two-step reagents, after being cleaned by the primary cleaning module 9, the sample transfer manipulator 77 transfers the reaction cups to the incubation tray module 66. Then, the reagent needle module 76 adds reagents again for constant temperature timed incubation. After that, the sample transfer manipulator 77 grabs the reaction cups out to the secondary cleaning module 301 for cleaning. After cleaning is completed, they are grabbed to the reading module 401 for reading and measuring the concentration value, and then the reaction cups are discarded.

[0070] The technical features of the above-described embodiments can be combined arbitrarily. For the sake of brevity of description, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, it should be considered as the scope recorded in this specification.

[0071] The above-described embodiments merely represent several implementation manners of the present invention. The description is relatively specific and detailed, but it should not be construed as a limitation on the scope of the invention patent. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present invention, several modifications and improvements can still be made, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the present invention patent shall be subject to the appended claims.

Claims

1. A high-speed fully automatic chemiluminescence immunoassay analyzer, comprising a workbench (100), characterized in that: At the upper end of the workbench (100), there are a sample loading and unloading module (1), a sample transfer module (3), a consumable automatic supply module (5), a consumable constant temperature turntable (51), a consumable transfer manipulator (54), a sample needle module (61), a reagent storage module (63), an incubation plate module (66), a reagent needle module (76), a primary cleaning module (9), a secondary cleaning module (301), a sample transfer manipulator (77), and a reading module (401); A conveying docking relationship is formed between the sample loading and unloading module (1) and the sample transfer module (3), and the sample transfer module (3) transfers the samples stored in the sample loading and unloading module (1); A conveying docking relationship is formed between the consumable automatic supply module (5) and the consumable constant temperature turntable (51), and the consumable automatic supply module (5) is used to transfer reaction cup consumables into the consumable constant temperature turntable (51); A conveying docking relationship is formed between the consumable transfer manipulator (54) and the consumable constant temperature turntable (51), the incubation plate module (66), and the sample independent mixing module (8), and the consumable transfer manipulator (54) is used to grasp the reaction cups in the consumable constant temperature turntable (51) and transfer them to the incubation plate module (66); A conveying docking relationship is formed between the sample needle module (61) and the sample transfer module (3) and the incubation plate module (66), and the sample needle module (61) is used to transfer the samples in the sample transfer module (3) into the reaction cups in the incubation plate module (66); A conveying docking relationship is formed between the reagent needle module (76) and the reagent storage module (63) and the incubation plate module (66), and the reagent needle module (76) is used to transfer the reagents in the reagent storage module (63) into the reaction cups of the incubation plate module (66); A conveying docking relationship is formed between the sample transfer manipulator (77) and the incubation plate module (66), the primary cleaning module (9), the reading module (401), and the secondary cleaning module (301). The sample transfer manipulator (77) can grasp and transfer the reaction cups among the incubation plate module (66), the primary cleaning module (9), the reading module (401), and the secondary cleaning module (301). The incubation plate module (66) is used to incubate the samples in the reaction cups. The primary cleaning module (9) is used to perform primary cleaning on the samples in the reaction cups. The secondary cleaning module (301) is used to perform secondary cleaning on the samples in the reaction cups. The reading module (401) is used to read the detection values of the samples in the reaction cups; A sample transfer module (2) is provided between the sample loading and unloading module (1) and the sample transfer module (3), and the sample transfer module (2) is used to transfer the samples on the sample loading and unloading module (1) to the sample transfer module (3); A sample independent mixing module (8) is provided at the upper end of the workbench (100). The sample independent mixing module (8) is arranged between the incubation plate module (66), the sample transfer position (71), and the consumable constant temperature turntable (51), and the sample independent mixing module (8) is used to mix the samples and reagents; The sample loading and unloading module (1) includes a regular sample module (11), an emergency sample module (12), and an online sample module (13). The sample transfer module (2) includes a sample stage (21) and a first driving mechanism (22). The first driving mechanism (22) is used to drive the sample stage (21) to displace between the sample loading and unloading module (1) and the sample transmission module (3).

2. The high-speed fully automatic chemiluminescence immunoassay analyzer according to claim 1, wherein: A sample transfer position (71) is further provided at the upper end of the workbench (100). The sample transfer position (71) is located between the incubation tray module (66) and the sample needle module (61), and the sample transfer position (71) is used for diluting the sample.

3. The high-speed fully automatic chemiluminescence immunoassay analyzer according to claim 2, wherein: A conveying docking relationship is formed between the consumable transfer manipulator (54) and the sample transfer position (71). The consumable transfer manipulator (54) is used to grab the reaction cup from the consumable constant temperature turntable (51) into the sample transfer position (71) or grab the sample at the sample transfer position (71) into the incubation tray module (66).

4. A high-speed fully automatic chemiluminescence immunoassay analyzer according to claim 1, characterized in that: The consumable constant temperature turntable (51) includes a first heating sheet (53). The incubation tray module (66) includes a second heating sheet (67). The first cleaning module (9) and the second cleaning module (301) respectively include a first heating block (208) and a second heating block.

5. A high-speed fully automatic chemiluminescence immunoassay analyzer according to claim 1, characterized in that: The consumable constant temperature turntable (51) includes a first temperature sensor. The incubation tray module (66) includes a second temperature sensor (68).

6. The high-speed fully automatic chemiluminescence immunoassay analyzer according to claim 1, wherein: The reagent storage module (63) includes a refrigeration plate and a semiconductor refrigeration sheet, and the refrigeration plate abuts against the semiconductor refrigeration sheet.

7. The high-speed fully automatic chemiluminescence immunoassay analyzer according to claim 1, wherein: The reading module (401) includes an excitation liquid adding mechanism (501), and the excitation liquid adding mechanism (501) includes a heating wire (502).

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